Search scope and keyword families used to build the corpus. Disease and intervention terms are grouped by sub-category so it's clear which families are well-covered and which are sparse — empty or small sub-groups are direct candidates for the next search-refinement iteration.
Where the corpus shrinks and where signal concentrates. The drop from raw to dedup is mostly cross-source overlap; the drop to linked indicates how many articles are tied to a registered trial.
Each article is counted under every source that returned it. A high multi-source overlap means the pipeline is robust; a high single-source share means dropping any one source would leave gaps. 1396 of 7659 articles (18%) appear in 2+ sources — these are the highest-confidence records. 190 preprints (medRxiv/bioRxiv) are included and shown in amber.
| ID | Title | Year | Journal | Source | Linked NCTs |
|---|---|---|---|---|---|
| PMID:30325677.0 | Guided graded Exercise Self-help for chronic fatigue syndrome: patient experiences and perceptions. | 2020 | Disability and rehabilitation | PubMed | nan |
| PMID:30380922.0 | Feedback on underperformance in patients with Chronic Fatigue Syndrome: The impact on subsequent neuropsychological test performance. | 2020 | Applied neuropsychology. Adult | PubMed | nan |
| PMID:30455072.0 | Antioxidant and immunomodulatory properties of Spilanthes oleracea with potential effect in chronic fatigue syndrome infirmity. | 2020 | Journal of Ayurveda and integrative medicine | PubMed | nan |
| PMID:30655187.0 | Hypophosphatasia in Adults: Clinical Spectrum and Its Association With Genetics and Metabolic Substrates. | 2020 | Journal of clinical densitometry : the official journal of the International Society for Clinical De | PubMed | nan |
| PMID:31113527.0 | Psychometric properties of the Cognitive and Behavioural Responses Questionnaire (CBRQ) in adolescents with chronic fatigue syndrome. | 2020 | Behavioural and cognitive psychotherapy | PubMed | nan |
| PMID:31215392.0 | Syndrome of Supine Hypertension with Orthostatic Hypotension: Pathophysiology and Clinical Approach. | 2020 | Current cardiology reviews | PubMed | nan |
| PMID:31234662.0 | Monitoring treatment harm in myalgic encephalomyelitis/chronic fatigue syndrome: A freedom-of-information study of National Health Service specialist centres in England. | 2021 | Journal of health psychology | PubMed | nan |
| PMID:31297663.0 | Dysautonomia in Guillain-Barré Syndrome: Prevalence, Clinical Spectrum, and Outcomes. | 2020 | Neurocritical care | PubMed | nan |
| PMID:31304956.0 | Species interactions modulate the response of saltmarsh plants to flooding. | 2020 | Annals of botany | PubMed | nan |
| PMID:31376088.0 | Systemic sclerosis and urinary symptoms: a complex pathophysiology. | 2020 | Clinical rheumatology | PubMed | nan |
| PMID:31407924.0 | How do women suffering from multiple chemical sensitivity experience the medical encounter? a qualitative study in Spain. | 2021 | Disability and rehabilitation | PubMed | nan |
| PMID:31412221.0 | Postural Orthostatic Tachycardia Syndrome: Mechanisms and New Therapies. | 2020 | Annual review of medicine | Europe PMC; PubMed | NCT07019519 |
| PMID:31461628.0 | Brain Responses in CFS and TMD to Autonomic Challenges: An Exploratory fMRI Study. | 2020 | JDR clinical and translational research | PubMed | nan |
| PMID:31483181.0 | Is the efficacy of repetitive transcranial magnetic stimulation influenced by baseline severity of fatigue symptom in patients with myalgic encephalomyelitis. | 2020 | The International journal of neuroscience | PubMed | NCT07278206 |
| PMID:31524844.0 | The Relationship Between Autonomic Dysfunction of the Gastrointestinal Tract and Emotional Distress in Patients With Systemic Sclerosis. | 2021 | Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases | PubMed | nan |
| PMID:31561388.0 | Intervening Effects of Orthostatic Blood Pressure Change on Subcortical Atrophy and Cognition in De Novo and Drug-Naïve Parkinson's Disease. | 2020 | Journal of Parkinson's disease | PubMed | nan |
| PMID:31583504.0 | Effects of plant growth-promoting bacteria on EDTA-assisted phytostabilization of heavy metals in a contaminated calcareous soil. | 2020 | Environmental geochemistry and health | PubMed | nan |
| PMID:31644656.0 | Root-knot nematode, Meloidogyne javanica, in response to soil fertilization. | 2020 | Brazilian journal of biology = Revista brasleira de biologia | PubMed | nan |
| PMID:31661696.0 | Risk of Multiple System Atrophy and the Use of Anti-Inflammatory Drugs: A Danish Register-Based Case-Control Study. | 2020 | Neuroepidemiology | PubMed | nan |
| PMID:31669585.0 | Characterization of 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidases from Borrelia burgdorferi: Antibiotic targets for Lyme disease. | 2020 | Biochimica et biophysica acta. General subjects | PubMed | nan |
| PMID:31669858.0 | News and views in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS): The role of co-morbidity and novel treatments. | 2020 | Medical hypotheses | PubMed | nan |
| PMID:31672071.0 | Screening for Orthostatic Intolerance in Symptomatic Children Presenting for Concussion Care. | 2020 | Clinical pediatrics | PubMed | nan |
| PMID:31704209.0 | Efficacy of entomopathogenic nematodes in insect cadaver formulation against engorged females of Rhipicephalus microplus (Acari: Ixodidae) in semi-field conditions. | 2020 | Ticks and tick-borne diseases | PubMed | nan |
| PMID:31707447.0 | Delayed diagnosis of posterior ankle impingement in pediatric and adolescent patients: does radiology play a role? | 2020 | Pediatric radiology | PubMed | nan |
| PMID:31713746.0 | Management of anticoagulated patients in dentoalveolar surgery: a clinical comparative study. | 2020 | Clinical oral investigations | PubMed | nan |
| PMID:31732848.0 | Treatment of Movement Disorder Emergencies in Autoimmune Encephalitis in the Neurosciences ICU. | 2020 | Neurocritical care | PubMed | nan |
| PMID:31733544.0 | Quantification of metal uptake in Spinacia oleracea irrigated with water containing a mixture of CuO and ZnO nanoparticles. | 2020 | Chemosphere | PubMed | nan |
| PMID:31745685.0 | Comparison of Nd:YAG laser (532 nm green) vs diode laser (810 nm) photocoagulation in the treatment of retinopathy of prematurity: an evaluation in terms of complications. | 2020 | Lasers in medical science | PubMed | nan |
| PMID:31747629.0 | Remediation of industrial wastewater using four hydrophyte species: A comparison of individual (pot experiments) and mix plants (constructed wetland). | 2020 | Journal of environmental management | PubMed | nan |
| PMID:31794439.0 | A MAPP Network Case-control Study of Urological Chronic Pelvic Pain Compared With Nonurological Pain Conditions. | 2020 | The Clinical journal of pain | PubMed | nan |
| PMID:31826926.0 | Conceptualising illness and disease: reflections on Sharpe and Greco (2019). | 2020 | Medical humanities | PubMed | nan |
| PMID:31830003.0 | Myalgic encephalomyelitis/chronic fatigue syndrome patients exhibit altered T cell metabolism and cytokine associations. | 2020 | The Journal of clinical investigation | PubMed | NCT05273372; NCT05664711 |
| PMID:31840339.0 | Can linguistic analysis be used to identify whether adolescents with a chronic illness are depressed? | 2020 | Clinical psychology & psychotherapy | PubMed | nan |
| PMID:31848771.0 | Prevalence and factors related to orthostatic syndromes in recently diagnosed, drug-naïve patients with Parkinson disease. | 2020 | Clinical autonomic research : official journal of the Clinical Autonomic Research Society | PubMed | nan |
| PMID:31858811.0 | Epidemiological and clinical features of amyotrophic lateral sclerosis in a Tunisian cohort. | 2020 | Amyotrophic lateral sclerosis & frontotemporal degeneration | PubMed | nan |
| PMID:31884303.0 | Post-exertional malaise is associated with greater symptom burden and psychological distress in patients diagnosed with Chronic Fatigue Syndrome. | 2020 | Journal of psychosomatic research | PubMed | nan |
| PMID:31902915.0 | Neuroinflammation, Oxidative Stress, and Neurogenesis in a Mouse Model of Chronic Fatigue Syndrome, and the Treatment with Kampo Medicine. | 2020 | Biological & pharmaceutical bulletin | PubMed | nan |
| PMID:31910209.0 | Post mortem evaluation of inflammation, oxidative stress, and PPARγ activation in a nonhuman primate model of cardiac sympathetic neurodegeneration. | 2020 | PloS one | PubMed | nan |
| PMID:31923274.0 | Metabolic analysis of amino acids and vitamin B6 pathways in lymphoma survivors with cancer related chronic fatigue. | 2020 | PloS one | PubMed | nan |
| PMID:31924165.0 | The pan-genome of Treponema pallidum reveals differences in genome plasticity between subspecies related to venereal and non-venereal syphilis. | 2020 | BMC genomics | PubMed | nan |
| PMID:31955045.0 | Recycling industrial biosludge for buffel grass production in Qatar: Impact on soil, leachate and plant characteristics. | 2020 | Chemosphere | PubMed | nan |
| PMID:31957505.0 | State-of-the-art pharmacotherapy for autonomic dysfunction in Parkinson's disease. | 2020 | Expert opinion on pharmacotherapy | PubMed | nan |
| PMID:31957647.0 | Parasympathetic activity is reduced during slow-wave sleep, but not resting wakefulness, in patients with chronic fatigue syndrome. | 2020 | Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Me | PubMed | nan |
| PMID:31959114.0 | In-vitro and in-vivo antioxidant assays of chicory plants (Cichorium intybus L.) as influenced by organic and conventional fertilisers. | 2020 | BMC plant biology | PubMed | nan |
| PMID:31979237.0 | Variation in Root and Shoot Growth in Response to Reduced Nitrogen. | 2020 | Plants (Basel, Switzerland) | PubMed | nan |
| PMID:32020880.0 | Treating medically unexplained symptoms via improving access to psychological therapy (IAPT): major limitations identified. | 2020 | BMC psychology | PubMed | nan |
| PMID:32021614.0 | Prevalence and treatment of Chronic Fatigue Syndrome/Myalgic Encephalomyelitis and co-morbid severe health anxiety. | 2020 | International journal of clinical and health psychology : IJCHP | PubMed | nan |
| PMID:32030573.0 | Dipteryx alata, a tree native to the Brazilian Cerrado, is sensitive to the herbicide nicosulfuron. | 2020 | Ecotoxicology (London, England) | PubMed | nan |
| PMID:32047163.0 | Hydraulic, wash-off and sediment transport experiments in a full-scale urban drainage physical model. | 2020 | Scientific data | PubMed | nan |
| PMID:32056488.0 | Microorganisms in the phylloplane modulate the BVOC emissions of Brassica nigra leaves. | 2020 | Plant signaling & behavior | PubMed | nan |
| ID | Title | Year | Journal | Source | Linked NCTs |
|---|---|---|---|---|---|
| PMID:31412221.0 | Postural Orthostatic Tachycardia Syndrome: Mechanisms and New Therapies. | 2020 | Annual review of medicine | Europe PMC; PubMed | NCT07019519 |
| PMID:32123189.0 | Azlocillin can be the potential drug candidate against drug-tolerant Borrelia burgdorferi sensu stricto JLB31. | 2020 | Scientific reports | Europe PMC; PubMed | nan |
| PMID:32140630.0 | Cerebral blood flow is reduced in ME/CFS during head-up tilt testing even in the absence of hypotension or tachycardia: A quantitative, controlled study using Doppler echography. | 2020 | Clinical neurophysiology practice | Europe PMC; PubMed | nan |
| PMID:32145864.0 | Canadian Cardiovascular Society Position Statement on Postural Orthostatic Tachycardia Syndrome (POTS) and Related Disorders of Chronic Orthostatic Intolerance. | 2020 | The Canadian journal of cardiology | Europe PMC; PubMed | NCT05404672; NCT05855356 |
| PMID:32171889.0 | Complex syndromes of chronic pain, fatigue and cognitive impairment linked to autoimmune dysautonomia and small fiber neuropathy. | 2020 | Clinical immunology (Orlando, Fla.) | Europe PMC; PubMed | nan |
| PMID:32314650.0 | Pediatric-Onset Postural Orthostatic Tachycardia Syndrome in a Single Tertiary Care Center. | 2020 | Journal of child neurology | Europe PMC; PubMed | nan |
| PMID:32411717.0 | Intravenous Cyclophosphamide in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome. An Open-Label Phase II Study. | 2020 | Frontiers in medicine | Europe PMC; OpenAlex; PubMed | nan |
| PMID:32434646.0 | [Vasovagal syncope or postural orthostatic tachycardia syndrome in children with neurological symptoms at disease onset: a clinical analysis of 88 cases]. | 2020 | Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics | Europe PMC; PubMed | nan |
| PMID:32489723.0 | Ivabradine in Postural Orthostatic Tachycardia Syndrome: A Review of the Literature. | 2020 | Cureus | Europe PMC; PubMed | nan |
| PMID:32498748.0 | Ivabradine in children with postural orthostatic tachycardia syndrome: a retrospective study. | 2020 | Cardiology in the young | Europe PMC; PubMed | nan |
| PMID:32606041.0 | Bupropion in the treatment of postural orthostatic tachycardia syndrome (POTS): a single-center experience. | 2020 | Journal of investigative medicine : the official publication of the American Federation for Clinical | Europe PMC; PubMed | nan |
| PMID:32651146.0 | Short-term efficacy of ORS formulation and propranolol regimen in children with POTS. | 2020 | Archives de pediatrie : organe officiel de la Societe francaise de pediatrie | Europe PMC; PubMed | nan |
| PMID:32654554.0 | Carbidopa for Afferent Baroreflex Failure in Familial Dysautonomia: A Double-Blind Randomized Crossover Clinical Trial. | 2020 | Hypertension (Dallas, Tex. : 1979) | Europe PMC; PubMed | nan |
| PMID:32655482.0 | Update of Individualized Treatment Strategies for Postural Orthostatic Tachycardia Syndrome in Children. | 2020 | Frontiers in neurology | Europe PMC; PubMed | nan |
| PMID:32757696.0 | Imaging findings of pelvic venous insufficiency in patients with postural orthostatic tachycardia syndrome. | 2021 | Phlebology | Europe PMC; OpenAlex; PubMed | nan |
| PMID:32858987.0 | Evaluation of Disulfiram Drug Combinations and Identification of Other More Effective Combinations against Stationary Phase Borrelia burgdorferi. | 2020 | Antibiotics (Basel, Switzerland) | Europe PMC; PubMed | nan |
| PMID:32974246.0 | Postural Tachycardia Syndrome in Children and Adolescents: Pathophysiology and Clinical Management. | 2020 | Frontiers in pediatrics | Europe PMC; PubMed | nan |
| PMID:32975577.0 | Metabolic Response in Patients With Post-treatment Lyme Disease Symptoms/Syndrome. | 2021 | Clinical infectious diseases : an official publication of the Infectious Diseases Society of America | Europe PMC; PubMed | nan |
| PMID:32985294.0 | Daily Life Experiences: Challenges, Strategies, and Implications for Therapy in Postural Tachycardia Syndrome (POTS). | 2022 | Occupational therapy in health care | Europe PMC; PubMed | nan |
| PMID:32994327.0 | A Distinct Microbiome Signature in Posttreatment Lyme Disease Patients. | 2020 | mBio | Europe PMC; OpenAlex; PubMed | nan |
| PMID:33024496.0 | Non-Pharmacological and Pharmacological Management of Cardiac Dysautonomia Syndromes. | 2020 | Journal of atrial fibrillation | Europe PMC; PubMed | nan |
| PMID:33024503.0 | Defining Cardiac Dysautonomia - Different Types, Overlap Syndromes; Case-based Presentations. | 2020 | Journal of atrial fibrillation | Europe PMC; PubMed | nan |
| PMID:33083000.0 | Protocol for a randomised controlled feasibility trial of exercise rehabilitation for people with postural tachycardia syndrome: the PULSE study. | 2020 | Pilot and feasibility studies | Europe PMC; OpenAlex; PubMed | nan |
| PMID:33119613.0 | Effect of disease duration in a randomized Phase III trial of rintatolimod, an immune modulator for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome. | 2020 | PloS one | Europe PMC; PubMed | nan |
| PMID:33168903.0 | Evaluation of pathogen specific urinary peptides in tick-borne illnesses. | 2020 | Scientific reports | Europe PMC; PubMed | nan |
| PMID:33181565.0 | Postural Orthostatic Tachycardia Syndrome and Disordered Eating: Clarifying the Overlap. | 2021 | Journal of developmental and behavioral pediatrics : JDBP | Europe PMC; PubMed | nan |
| PMID:33185628.0 | Amifampridine to treat Lambert-Eaton myasthenic syndrome. | 2020 | Drugs of today (Barcelona, Spain : 1998) | Europe PMC; PubMed | nan |
| PMID:33428036.0 | Regional Gastrointestinal Transit and Contractility Patterns Vary in Postural Orthostatic Tachycardia Syndrome (POTS). | 2021 | Digestive diseases and sciences | Europe PMC; PubMed | nan |
| PMID:33459162.0 | When POTS is the tip of the iceberg: Rare cases of dysautonomia as a possible manifestation of another disorder. | 2021 | Lupus | Europe PMC; PubMed | nan |
| PMID:33478652.0 | Compression Garment Reduces Orthostatic Tachycardia and Symptoms in Patients With Postural Orthostatic Tachycardia Syndrome. | 2021 | Journal of the American College of Cardiology | Europe PMC; PubMed | nan |
| PMID:33482385.0 | Cardiovascular exercise as a treatment of postural orthostatic tachycardia syndrome: A pragmatic treatment trial. | 2021 | Heart rhythm | Europe PMC; OpenAlex; PubMed | nan |
| PMID:33528911.0 | Open-label study with the monoamine stabilizer (-)-OSU6162 in myalgic encephalomyelitis/chronic fatigue syndrome. | 2021 | Brain and behavior | Europe PMC; PubMed | nan |
| PMID:33529750.0 | Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS): Where will the drugs come from? | 2021 | Pharmacological research | Europe PMC; PubMed | nan |
| PMID:33557013.0 | Diagnostic and Pharmacological Potency of Creatine in Post-Viral Fatigue Syndrome. | 2021 | Nutrients | Europe PMC; PubMed | nan |
| PMID:33602468.0 | Randomized Trial of Ivabradine in Patients With Hyperadrenergic Postural Orthostatic Tachycardia Syndrome. | 2021 | Journal of the American College of Cardiology | Europe PMC; PubMed | nan |
| PMID:33677650.0 | Is postural orthostatic tachycardia syndrome (POTS) a central nervous system disorder? | 2022 | Journal of neurology | Europe PMC; PubMed | nan |
| PMID:33735220.0 | A comprehensive clinical and laboratory evaluation of 224 patients with persistent symptoms attributed to presumed tick-bite exposure. | 2021 | PloS one | Europe PMC; PubMed | nan |
| PMID:33774355.0 | Evaluation of selected variables to determine if any had predictive value for, or correlated with, residual symptoms at approximately 12 months after diagnosis and treatment of early Lyme disease. | 2021 | Diagnostic microbiology and infectious disease | Europe PMC; PubMed | nan |
| PMID:33781531.0 | Central Nervous System Involvement in Epstein-Barr Virus-Related Post-Transplant Lymphoproliferative Disorders after Allogeneic Hematopoietic Stem Cell Transplantation. | 2021 | Transplantation and cellular therapy | Europe PMC; PubMed | nan |
| PMID:33810365.0 | Insights into Metabolite Diagnostic Biomarkers for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome. | 2021 | International journal of molecular sciences | Europe PMC; PubMed | nan |
| PMID:33829023.0 | Reduced Endothelial Function in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome-Results From Open-Label Cyclophosphamide Intervention Study. | 2021 | Frontiers in medicine | Europe PMC; OpenAlex; PubMed | nan |
| PMID:33886735.0 | Dysautonomia: A Forgotten Condition - Part 1. | 2021 | Arquivos brasileiros de cardiologia | Europe PMC; OpenAlex; PubMed | nan |
| PMID:33901811.0 | Understanding the future research needs in Postural Orthostatic Tachycardia Syndrome (POTS): Evidence mapping the POTS adult literature. | 2021 | Autonomic neuroscience : basic & clinical | Europe PMC; PubMed | nan |
| PMID:34020666.0 | Publisher Correction to: Off label use of Aripiprazole shows promise as a treatment for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS): a retrospective study of 101 patients treated with a low dose of Aripip | 2021 | Journal of translational medicine | Europe PMC; PubMed | nan |
| PMID:34024217.0 | Long COVID or post-COVID-19 syndrome: putative pathophysiology, risk factors, and treatments. | 2021 | Infectious diseases (London, England) | Europe PMC; PubMed | nan |
| PMID:34026797.0 | Theory: Treatments for Prolonged ICU Patients May Provide New Therapeutic Avenues for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS). | 2021 | Frontiers in medicine | Europe PMC; OpenAlex; PubMed | nan |
| PMID:34042908.0 | Posttreatment Lyme Disease Syndrome-What It Might Be and What It Is Not. | 2021 | The Pediatric infectious disease journal | Europe PMC; PubMed | nan |
| PMID:34117922.0 | Postural orthostatic tachycardia syndrome: insights into pathogenesis and treatment. | 2021 | Journal of neurology | Europe PMC; PubMed | nan |
| PMID:34144933.0 | Postural orthostatic tachycardia syndrome (POTS): State of the science and clinical care from a 2019 National Institutes of Health Expert Consensus Meeting - Part 1. | 2021 | Autonomic neuroscience : basic & clinical | Europe PMC; PubMed | NCT06953661 |
| PMID:34201806.0 | Effect of Melatonin Plus Zinc Supplementation on Fatigue Perception in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Randomized, Double-Blind, Placebo-Controlled Trial. | 2021 | Antioxidants (Basel, Switzerland) | Europe PMC; Preprint (medRxiv/bioRxiv); PubMed | NCT05454683 |
| NCT ID | Title | Status | Phase | Sponsor | Intervention |
|---|---|---|---|---|---|
| NCT04871815 | Preliminary Examination of the Effects of Sodium Pyruvate Nasal Spray (N115) on Symptoms Associated With COVID19 Long Haulers. | COMPLETED | PHASE2; PHASE3 | Cellular Sciences, inc. | sodium pyruvate nasal spray |
| NCT05104749 | Homeopathic Treatment of Post-acute COVID-19 Syndrome- A Pilot Randomized Controlled Trial | COMPLETED | PHASE3 | Southwest College of Naturopathic Medicine | Homeopathic Medication; Placebo |
| NCT04510194 | COVID-OUT: Early Outpatient Treatment for SARS-CoV-2 Infection (COVID-19) | COMPLETED | PHASE3 | University of Minnesota | Metformin; Placebo; Fluvoxamine; Ivermectin |
| NCT05212610 | Assessing Safety of COVID-19 mRNA Vaccine Administration in the Setting of a Previous Adverse Reaction | COMPLETED | PHASE4 | University of Michigan | Pfizer-BioNTech mRNA COVID-19 vaccine; Moderna mRNA COVID-19 vaccine |
| NCT05999435 | A DOUBLE-BLIND, RANDOMIZED, PLACEBO-CONTROLLED, ADAPTIVE PHASE 2/3 STUDY OF THE EFFICACY OF LAU-7b IN THE TREATMENT OF ADULTS WITH LONG COVID AND MODERATE TO SEVERE SYMPTOMS | COMPLETED | PHASE2; PHASE3 | Laurent Pharmaceuticals Inc. | LAU-7b for 3 cycles; LAU-7b for 1 cycle, then placebo; Placebo for 3 cycles |
| NCT05074888 | A Multicenter, Double-blind, Placebo-controlled, Parallel-group, Randomized Clinical Trial of Efficacy and Safety of Prospekta in the Treatment of Patients With Post-COVID-19 Asthe | COMPLETED | PHASE3 | Materia Medica Holding | Prospekta; Placebo |
| NCT05047952 | Randomized, Double-Blinded, Placebo-Controlled Study Evaluating Vortioxetine for Cognitive Deficits in Persons With Post-COVID-19 Condition | COMPLETED | PHASE2 | Brain and Cognition Discovery Foundation | Vortioxetine; Placebo |
| NCT05970731 | Directed Topical Drug Delivery for Treatment for PASC Hyposmia | COMPLETED | PHASE2 | Duke University | Beclomethasone; Placebo; Microsponge |
| NCT05633407 | A Phase 2 Randomized, Double-blinded, Placebo-controlled Study to Evaluate the Efficacy and Safety of Efgartigimod IV in Adult Patients With Post-COVID-19 Postural Orthostatic Tach | COMPLETED | PHASE2 | argenx | Efgartigimod; Placebo |
| NCT04920916 | Safety and Efficacy of the Treatment of Hospitalized Patients With COVID 19 Infection With an Inhibitor of IL-4 and IL-13 Signaling: A Phase IIa Trial | COMPLETED | PHASE2 | University of Virginia | Dupilumab; Placebo |
| NCT05618587 | Effect of Low-dose Lithium Therapy on Long COVID Symptoms: a Randomized Controlled Trial. | COMPLETED | PHASE2 | State University of New York at Buffalo | Lithium; Placebo |
| NCT05592418 | A Randomized, Double Blind, Placebo Controlled Study to Evaluate the Efficacy and Safety of Ampligen® in Patients With Post-COVID Conditions | COMPLETED | PHASE2 | AIM ImmunoTech Inc. | Rintatolimod; Placebo / Normal Saline |
| NCT05121740 | Extension Study in a Cohort of Adult Patients With SARS-CoV-2 Infection Requiring Hospital Admission and Received Treatment With Plitidepsin in the APLICOV-PC Study | COMPLETED | PHASE1; PHASE2 | PharmaMar | Plitidepsin 1.5 mg / day; Plitidepsin 2.0 mg / day; Plitidepsin 2.5 mg / day |
| NCT05576662 | Selective Trial Of Paxlovid for PASC (STOP-PASC): Randomized Double-Blind Placebo-Controlled Pilot Trial of Paxlovid for the Treatment of PASC | COMPLETED | PHASE2 | Stanford University | Nirmatrelvir; Placebo; Ritonavir |
| NCT04141696 | A Proof-of-Concept Trial on the Effect of Ketamine on Fatigue | COMPLETED | PHASE1; PHASE2 | National Institute of Nursing Research (NINR) | Ketamine; Midazolam |
| NCT06133075 | Using Mirabegron to Increase Blood Pressure in Patients With Postural Orthostatic Tachycardia Syndrome | COMPLETED | PHASE2 | Cedars-Sinai Medical Center | Mirabegron 50 MG; Mirabegron 25 MG |
| NCT05965726 | RECOVER-VITAL: A Platform Protocol for Evaluation of Interventions for Viral Persistence, Viral Reactivation, and Immune Dysregulation in Post-Acute Sequelae of SARS-CoV-2 Infectio | COMPLETED | PHASE2 | Kanecia Obie Zimmerman | Paxlovid; Ritonavir; Nirmatrelvir-matching placebo |
| NCT04977388 | Phase I/II Study of NORTHERA (DROXIDOPA) for Dysautonomia in Adult Survivors of Menkes Disease and Adults With Occipital Horn Syndrome: Double-blind Placebo-controlled Randomized C | COMPLETED | PHASE1; PHASE2 | Stephen G. Kaler, MD | Droxidopa; Placebo |
| NCT03356821 | Adult Mesenchymal Stromal Cells to Regenerate the Neonatal Brain: the PASSIoN Trial (Perinatal Arterial Stroke Treated With Stromal Cells IntraNasally) | COMPLETED | PHASE1; PHASE2 | UMC Utrecht | Mesenchymal Stem Cells |
| NCT06253806 | Stellate Ganglion Block for the Treatment of COVID-19-Induced Parosmia: Double-Blinded, Placebo-Controlled Randomized Clinical Trial | COMPLETED | PHASE2 | Washington University School of Medicine | Stellate Ganglion Block; Placebo Sham Injection |
| NCT03674541 | The Exercise Response to Pharmacologic Cholinergic Stimulation in Myalgic Encephalomyelitis / Chronic Fatigue Syndrome | COMPLETED | PHASE2 | Brigham and Women's Hospital | Pyridostigmine Bromide; Placebo |
| NCT05126563 | A Randomized, Double-blinded, Single-center, Phase 2 Efficacy, and Safety Study of Allogeneic HB-adMSCs for the Treatment of Patients With Chronic Post-COVID-19 Syndrome. | COMPLETED | PHASE2 | Hope Biosciences Research Foundation | HB-adMSCs (allogeneic); Placebo |
| NCT05595369 | RECOVER-VITAL: A Platform Protocol for Evaluation of Interventions for Viral Persistence, Viral Reactivation, and Immune Dysregulation in Post-Acute Sequelae of SARS-CoV-2 Infectio | COMPLETED | PHASE2 | Kanecia Obie Zimmerman | Experimental: Paxlovid 25 day dosing; Experimental: Paxlovid 15 day dosing; Placebo Comparator: Control |
| NCT05445921 | Stellate Ganglion Block for the Treatment of COVID-19-Induced Olfactory Dysfunction: A Prospective Pilot Study | COMPLETED | PHASE1; PHASE2 | Washington University School of Medicine | Stellate Ganglion Block |
| NCT05472090 | A Phase 2, 14-week Double-Blind, Randomized, Multicenter, Placebo-Controlled Study to Evaluate the Efficacy and Safety of TNX-102 SL Taken Daily at Bedtime in Patients With Multisi | COMPLETED | PHASE2 | Tonix Pharmaceuticals, Inc. | TNX-102 SL; Placebo SL Tablet |
| NCT04828135 | Characterizing the Long-Term Cardiopulmonary Effects of COVID-19 With Hyperpolarized Xenon and Cardiac MRI | COMPLETED | PHASE2 | Bastiaan Driehuys | Hyperpolarized 129Xenon gas |
| NCT06136871 | Cognitive Strategy Training in Post-COVID-19 Syndrome: A Feasibility Trial | COMPLETED | nan | University of Missouri-Columbia | CO-OP Procedures; Inactive Control Group |
| NCT05970861 | Effect of Natural Food on Gut Microbiome and Phospholipid Spectrum of Immune Cells in COVID-19 Patients | COMPLETED | nan | Asfendiyarov Kazakh National Medical University | Freeze-dried Mare Milk (Saumal) |
| NCT06476496 | Pain Relief With Integrative Medicine (PRIMe)?: Feasibility of Acupuncture for Long COVID | COMPLETED | nan | University of Washington | Acupuncture |
| NCT05965752 | RECOVER-NEURO: A Platform Protocol for Evaluation of Interventions for Cognitive Dysfunction in Post-Acute Sequelae of SARS-CoV-2 Infection (PASC) | COMPLETED | nan | Duke University | BrainHQ/Active Comparator Activity; BrainHQ; PASC CoRE; tDCS-active; tDCS-sham |
| NCT05877508 | An Exploratory, Randomized, Double-Blind Placebo-Controlled Study to Assess the Safety of an Anti-SARS-CoV-2 Monoclonal Antibody and Response to Treatment in Individuals With Long | ACTIVE_NOT_RECRUITING | PHASE2 | Michael Peluso, MD | AER002; Placebo |
| NCT06208696 | Pilot Study to Evaluate the Role of an Evidenced-based Chronic-disease Self-management Program to Support Challenges Experiencing Patients Living With Long-COVID and Chronic Diseas | COMPLETED | nan | University of Puerto Rico | "Tomando control de su salud" (Spanish Chronic Disease Self-Management) |
| NCT04880161 | A Randomized, Double-Blinded, Placebo-Controlled Phase I Study to Evaluate the Safety and Efficacy of Ampion in Patients With Prolonged Respiratory Symptoms Due to COVID-19 (Long C | COMPLETED | PHASE1 | Ampio Pharmaceuticals. Inc. | Ampion; Placebo |
| NCT06161688 | Placebo-Controlled, Randomized Trial of Ensitrelvir (S-217622) for Viral Persistence and Inflammation in People Experiencing Long COVID (PREVAIL-LC) | ACTIVE_NOT_RECRUITING | PHASE2 | Timothy Henrich | Ensitrelvir; Placebo |
| NCT06268288 | Pilot Study--The Effects of Non-invasive Vagal Neurostimulation (nVNS) in Adolescents With Postural Orthostatic Tachycardia Syndrome (POTS) | COMPLETED | nan | Mayo Clinic | GammaCore intervention; STEPS management protocol |
| NCT05608629 | Vagus Nerve Stimulation as Treatment for Long Covid | COMPLETED | nan | Icahn School of Medicine at Mount Sinai | Transcutaneous Non-Invasive Vagus Nerve Stimulation |
| NCT06214455 | The Effect of a No-added Sugar Diet, Time-restricted Eating and Periodic Water Fasting on Long COVID Symptoms | COMPLETED | nan | Pacific Northwest University of Health Sciences | Low sugar diet and 10-12 hour eating window; Low sugar diet, 8 hour eating window and fasting |
| NCT05445427 | Outcomes of Treatment With Vagal Nerve Stimulation in Post-COVID Syndrome: A Pilot Study | COMPLETED | nan | Mayo Clinic | vagal nerve stimulator |
| NCT05199233 | The Benefit of Mindfulness-Based Intervention Using A Wearable Wellness Brain Sensing Device (Muse-S™) in the Treatment of Post-Covid Symptoms | COMPLETED | nan | Mayo Clinic | Muse S™ Headband system |
| NCT05453201 | Developing an Integrative, Recovery-Based, Post-Acute COVID-19 Syndrome (PACS) Psychotherapeutic Intervention | COMPLETED | nan | VA Office of Research and Development | Long COVID Coping and Recovery (LCCR) Intervention |
| NCT05473039 | OvoVid Study: Effect of a Multivitamin Supplement With Probiotic (Seidivid Ferty4®) on Oocyte Retrieval and Quality in Oocyte Donors. Double-blind Randomized Placebo-controlled Cli | COMPLETED | nan | SEID S.A. | Seidivid Ferty4; Placebo |
| NCT05200858 | Transcutaneous Electrical Nerve Stimulation For Lower Extremity In Patients With Neurogenic Pain - A Proof Of Concept Randomized Clinical Trial | COMPLETED | nan | Baylor College of Medicine | TENS - high-dose; TENS - low-dose |
| NCT05205460 | Effectiveness of a 12-week Telerehabilitation Training in People With Long COVID: A Randomized Controlled Trial | COMPLETED | nan | Tri-Service General Hospital | Home-based telerehabilitation; Education and self-exercise |
| NCT06208163 | Psychoneuroimmunology as a Framework for Studying the Effects of Chiropractic Care in a Population With High Central Adiposity: a Pilot Trial | COMPLETED | nan | Life University | Chiropractic |
| NCT06524739 | Double-blind, Randomized, Placebo-controlled Phase 3 Study Evaluating Efficacy and Safety of IgPro20 (Subcutaneous Immunoglobulin, HIZENTRA®) in Post-COVID-19 Postural Orthostatic | TERMINATED | PHASE3 | CSL Behring | IgPro20; Placebo |
| NCT05946551 | Feasibility Assessment of a Decentralized Platform Adaptive Double-Blind, Randomized Controlled Trial Investigating Repurposed Drugs in the Treatment of Post-Acute Sequelae of Coro | TERMINATED | PHASE3 | Emory University | Cetirizine; Famotidine; Cetirizine Placebo; Famotidine Placebo |
| NCT05092516 | Home-based Transcranial Direct Current Stimulation (tDCS) for Treatment of Cognitive Post-acute Sequelae of COVID-19 (PASC) | ACTIVE_NOT_RECRUITING | nan | Massachusetts General Hospital | Active tDCS; Sham tDCS |
| NCT04938687 | Pilot, Effect of Respiratory-Gated Auricular Vagal Afferent Nerve Stimulation (RAVANS) on Post-Treatment Lyme Disease Syndrome | COMPLETED | nan | Spaulding Rehabilitation Hospital | respiratory-gated auricular vagal afferent nerve stimulation (RAVANS); Sham RAVANS |
| NCT05597722 | Randomized Study to Evaluate Strategies to Address Cognitive Fog in Long-COVID-19 Patients | TERMINATED | PHASE4 | Eva Szigethy | Digital cognitive behavioral intervention-RxWell; Amphetamine-Dextroamphetamine |
| NCT04313972 | IC PaIN Trial: Interstitial Cystitis Pain Improvement With Naltrexone, the Effect of Low Dose Naltrexone on Symptoms and Pain of Patients With Interstitial Cystitis/Painful Bladder | TERMINATED | PHASE4 | Endeavor Health | low-dose naltrexone; Placebo oral tablet |
| ID | Title | Year | Journal | Source | Linked NCTs |
|---|---|---|---|---|---|
| PMID:32411717.0 | Intravenous Cyclophosphamide in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome. An Open-Label Phase II Study. | 2020 | Frontiers in medicine | Europe PMC; OpenAlex; PubMed | nan |
| PMID:32426159.0 | The feasibility and acceptability of an early intervention in primary care to prevent chronic fatigue syndrome (CFS) in adults: randomised controlled trial. | 2020 | Pilot and feasibility studies | OpenAlex; PubMed | nan |
| PMID:32568143.0 | Post-exertional symptoms distinguish Myalgic Encephalomyelitis/Chronic Fatigue Syndrome subjects from healthy controls. | 2020 | Work (Reading, Mass.) | OpenAlex; PubMed | nan |
| PMID:32757696.0 | Imaging findings of pelvic venous insufficiency in patients with postural orthostatic tachycardia syndrome. | 2021 | Phlebology | Europe PMC; OpenAlex; PubMed | nan |
| PMID:32784188.0 | Recruiting Adolescents With Chronic Fatigue Syndrome/Myalgic Encephalomyelitis to Internet-Delivered Therapy: Internal Pilot Within a Randomized Controlled Trial. | 2020 | Journal of medical Internet research | OpenAlex; PubMed | nan |
| PMID:32994327.0 | A Distinct Microbiome Signature in Posttreatment Lyme Disease Patients. | 2020 | mBio | Europe PMC; OpenAlex; PubMed | nan |
| PMID:33083000.0 | Protocol for a randomised controlled feasibility trial of exercise rehabilitation for people with postural tachycardia syndrome: the PULSE study. | 2020 | Pilot and feasibility studies | Europe PMC; OpenAlex; PubMed | nan |
| PMID:33176575.0 | Sick of the Sick Role: Narratives of What "Recovery" Means to People With CFS/ME. | 2021 | Qualitative health research | OpenAlex; PubMed | nan |
| PMID:33482385.0 | Cardiovascular exercise as a treatment of postural orthostatic tachycardia syndrome: A pragmatic treatment trial. | 2021 | Heart rhythm | Europe PMC; OpenAlex; PubMed | nan |
| PMID:33603379.0 | The Psychological Experience and Intervention in Post-Acute COVID-19 Inpatients. | 2021 | Neuropsychiatric disease and treatment | OpenAlex; PubMed | nan |
| PMID:33829023.0 | Reduced Endothelial Function in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome-Results From Open-Label Cyclophosphamide Intervention Study. | 2021 | Frontiers in medicine | Europe PMC; OpenAlex; PubMed | nan |
| PMID:33886735.0 | Dysautonomia: A Forgotten Condition - Part 1. | 2021 | Arquivos brasileiros de cardiologia | Europe PMC; OpenAlex; PubMed | nan |
| PMID:33923830.0 | The Role of Prevention in Reducing the Economic Impact of ME/CFS in Europe: A Report from the Socioeconomics Working Group of the European Network on ME/CFS (EUROMENE). | 2021 | Medicina (Kaunas, Lithuania) | OpenAlex; PubMed | nan |
| PMID:34026797.0 | Theory: Treatments for Prolonged ICU Patients May Provide New Therapeutic Avenues for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS). | 2021 | Frontiers in medicine | Europe PMC; OpenAlex; PubMed | nan |
| PMID:34091456.0 | Swiss Recommendations for the Follow-Up and Treatment of Pulmonary Long COVID. | 2021 | Respiration; international review of thoracic diseases | OpenAlex; PubMed | nan |
| PMID:34246578.0 | Postural orthostatic tachycardia syndrome (POTS): Priorities for POTS care and research from a 2019 National Institutes of Health Expert Consensus Meeting - Part 2. | 2021 | Autonomic neuroscience : basic & clinical | Europe PMC; OpenAlex; PubMed | NCT07579026 |
| PMID:34262415.0 | A preliminary investigation of nutritional intake and supplement use in Australians with myalgic encephalomyelitis/chronic fatigue syndrome and the implications on health-related quality of life. | 2021 | Food & nutrition research | OpenAlex; PubMed | nan |
| PMID:34273080.0 | Spa therapy interventions for post respiratory rehabilitation in COVID-19 subjects: does the review of recent evidence suggest a role? | 2021 | Environmental science and pollution research international | OpenAlex; PubMed | NCT05178225; NCT06294756 |
| PMID:34300183.0 | Shadow Burden of Undiagnosed Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) on Society: Retrospective and Prospective-In Light of COVID-19. | 2021 | Journal of clinical medicine | Europe PMC; OpenAlex; PubMed | nan |
| PMID:34327047.0 | Management of Postural Orthostatic Tachycardia Syndrome in the Absence of Randomized Controlled Trials. | 2021 | The Journal of innovations in cardiac rhythm management | Europe PMC; OpenAlex; PubMed | nan |
| PMID:34423789.0 | A map of metabolic phenotypes in patients with myalgic encephalomyelitis/chronic fatigue syndrome. | 2021 | JCI insight | Europe PMC; OpenAlex; PubMed | nan |
| PMID:34441898.0 | Health, Wellbeing, and Prognosis of Australian Adolescents with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS): A Case-Controlled Follow-Up Study. | 2021 | Journal of clinical medicine | OpenAlex; PubMed | nan |
| PMID:34444817.0 | Effect of Dietary Coenzyme Q10 Plus NADH Supplementation on Fatigue Perception and Health-Related Quality of Life in Individuals with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Prospective, Randomized, Double- | 2021 | Nutrients | Europe PMC; OpenAlex; PubMed | NCT05454683 |
| PMID:34460414.0 | Effectiveness of an Internet-Based Machine-Guided Stress Management Program Based on Cognitive Behavioral Therapy for Improving Depression Among Workers: Protocol for a Randomized Controlled Trial. | 2021 | JMIR research protocols | OpenAlex; PubMed | nan |
| PMID:34564089.0 | A Randomized Controlled Trial of the Efficacy of Systemic Enzymes and Probiotics in the Resolution of Post-COVID Fatigue. | 2021 | Medicines (Basel, Switzerland) | OpenAlex; PubMed | nan |
| PMID:34640447.0 | Effectiveness of a Primary Care Telerehabilitation Program for Post-COVID-19 Patients: A Feasibility Study. | 2021 | Journal of clinical medicine | OpenAlex; PubMed | nan |
| PMID:34769934.0 | 'I Live a Kind of Shadow Life': Individual Experiences of COVID-19 Recovery and the Impact on Physical Activity Levels. | 2021 | International journal of environmental research and public health | OpenAlex; PubMed | nan |
| PMID:34785530.0 | Estimating the population health burden of Lyme disease in Ontario, Canada: a microsimulation modelling approach. | 2021 | CMAJ open | Europe PMC; OpenAlex; PubMed | nan |
| PMID:34838708.0 | COVID-19 Infections and Asthma. | 2022 | The journal of allergy and clinical immunology. In practice | OpenAlex; PubMed | nan |
| PMID:35870428.0 | COVID-19 lung disease shares driver AT2 cytopathic features with Idiopathic pulmonary fibrosis. | 2022 | EBioMedicine | OpenAlex; PubMed | nan |
| PMID:34898858.0 | A Brief Transdiagnostic Pandemic Mental Health Maintenance Intervention. | 2021 | Counselling psychology quarterly | OpenAlex; PubMed | nan |
| PMID:34901100.0 | A Botanical Product Containing Cistanche and Ginkgo Extracts Potentially Improves Chronic Fatigue Syndrome Symptoms in Adults: A Randomized, Double-Blind, and Placebo-Controlled Study. | 2021 | Frontiers in nutrition | OpenAlex; PubMed | nan |
| PMID:34966354.0 | Lessons From Heat Stroke for Understanding Myalgic Encephalomyelitis/Chronic Fatigue Syndrome. | 2021 | Frontiers in neurology | Europe PMC; OpenAlex; PubMed | nan |
| PMID:35056100.0 | An Open-Label, Pilot Trial of HRG80™ Red Ginseng in Chronic Fatigue Syndrome, Fibromyalgia, and Post-Viral Fatigue. | 2021 | Pharmaceuticals (Basel, Switzerland) | Europe PMC; OpenAlex; PubMed | nan |
| PMID:35166327.0 | Mobile Chat Messaging for Preventing Smoking Relapse Amid the COVID-19 Pandemic: A Pilot Randomized Controlled Trial. | 2023 | Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobac | OpenAlex; PubMed | nan |
| PMID:35195253.0 | A central role for amyloid fibrin microclots in long COVID/PASC: origins and therapeutic implications. | 2022 | The Biochemical journal | Europe PMC; OpenAlex; PubMed | nan |
| PMID:35206179.0 | Molecular Hydrogen Positively Affects Physical and Respiratory Function in Acute Post-COVID-19 Patients: A New Perspective in Rehabilitation. | 2022 | International journal of environmental research and public health | OpenAlex; PubMed | nan |
| PMID:35236727.0 | Inspiratory muscle training enhances recovery post-COVID-19: a randomised controlled trial. | 2022 | The European respiratory journal | OpenAlex; PubMed | NCT05597774; NCT05764070 |
| PMID:35313959.0 | Safety and long-term improvement of mesenchymal stromal cell infusion in critically COVID-19 patients: a randomized clinical trial. | 2022 | Stem cell research & therapy | OpenAlex; PubMed | NCT06492798 |
| PMID:35450527.0 | Ultramicronized Palmitoylethanolamide and Luteolin Supplement Combined with Olfactory Training to Treat Post-COVID-19 Olfactory Impairment: A Multi-Center Double-Blinded Randomized Placebo- Controlled Clinical Trial. | 2022 | Current neuropharmacology | OpenAlex; PubMed | nan |
| PMID:35468586.0 | Long COVID Optimal Health Program (LC-OHP) to Enhance Psychological and Physical Health: Protocol for a Feasibility Randomized Controlled Trial. | 2022 | JMIR research protocols | OpenAlex; PubMed | nan |
| PMID:35473345.0 | Ginger-indirect moxibustion plus acupuncture versus acupuncture alone for chronic fatigue syndrome: a randomized controlled trial. | 2022 | Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan | OpenAlex; PubMed | nan |
| PMID:35489367.0 | An online breathing and wellbeing programme (ENO Breathe) for people with persistent symptoms following COVID-19: a parallel-group, single-blind, randomised controlled trial. | 2022 | The Lancet. Respiratory medicine | OpenAlex; PubMed | nan |
| PMID:35521629.0 | Occupational Therapy-Based Energy Management Education in People with Post-COVID-19 Condition-Related Fatigue: Results from a Focus Group Discussion. | 2022 | Occupational therapy international | OpenAlex; PubMed | nan |
| PMID:35525992.0 | Protocol update for a randomised controlled feasibility trial of exercise rehabilitation for people with postural tachycardia syndrome: the PULSE study. | 2022 | Pilot and feasibility studies | Europe PMC; OpenAlex; PubMed | nan |
| PMID:35647070.0 | Sulodexide Significantly Improves Endothelial Dysfunction and Alleviates Chest Pain and Palpitations in Patients With Long-COVID-19: Insights From TUN-EndCOV Study. | 2022 | Frontiers in cardiovascular medicine | OpenAlex; PubMed | nan |
| PMID:35715857.0 | Combination of whole body cryotherapy with static stretching exercises reduces fatigue and improves functioning of the autonomic nervous system in Chronic Fatigue Syndrome. | 2022 | Journal of translational medicine | OpenAlex; PubMed | nan |
| PMID:35764955.0 | Oxaloacetate Treatment For Mental And Physical Fatigue In Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) and Long-COVID fatigue patients: a non-randomized controlled clinical trial. | 2022 | Journal of translational medicine | Europe PMC; OpenAlex; PubMed | NCT04592354; NCT05840237 |
| PMID:36002874.0 | A pilot randomized controlled trial of supervised, at-home, self-administered transcutaneous auricular vagus nerve stimulation (taVNS) to manage long COVID symptoms. | 2022 | Bioelectronic medicine | OpenAlex; PubMed | nan |
| PMID:35783877.0 | Efficacy and Safety of Aspirin, Promethazine, and Micronutrients for Rapid Clinical Recovery in Mild to Moderate COVID-19 Patients: A Randomized Controlled Clinical Trial. | 2022 | Cureus | OpenAlex; PubMed | nan |
| ID | Title | Year | Journal | Source | Linked NCTs |
|---|---|---|---|---|---|
| PMID:34201806.0 | Effect of Melatonin Plus Zinc Supplementation on Fatigue Perception in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Randomized, Double-Blind, Placebo-Controlled Trial. | 2021 | Antioxidants (Basel, Switzerland) | Europe PMC; Preprint (medRxiv/bioRxiv); PubMed | NCT05454683 |
| PMID:35478078.0 | Long COVID Citizen Scientists: Developing a Needs-Based Research Agenda by Persons Affected by Long COVID. | 2022 | The patient | Preprint (medRxiv/bioRxiv); PubMed | nan |
| PMID:35884166.0 | Efficacy of Short-Term High Dose Pulsed Dapsone Combination Therapy in the Treatment of Chronic Lyme Disease/Post-Treatment Lyme Disease Syndrome (PTLDS) and Associated Co-Infections: A Report of Three Cases and Literatu | 2022 | Antibiotics (Basel, Switzerland) | Europe PMC; Preprint (medRxiv/bioRxiv); PubMed | nan |
| PMID:36015078.0 | The Occurrence of Hyperactivated Platelets and Fibrinaloid Microclots in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS). | 2022 | Pharmaceuticals (Basel, Switzerland) | Europe PMC; Preprint (medRxiv/bioRxiv); PubMed | nan |
| PMID:36121492.0 | FORCE Risk Stratification Tool for Pediatric Cardiac Rehabilitation and Fitness Programs. | 2023 | Pediatric cardiology | Europe PMC; Preprint (medRxiv/bioRxiv); PubMed | nan |
| PMID:36284352.0 | Autoimmune gene expression profiling of fingerstick whole blood in Chronic Fatigue Syndrome. | 2022 | Journal of translational medicine | Europe PMC; Preprint (medRxiv/bioRxiv); PubMed | nan |
| PMID:36288329.0 | A multimodal neuroimaging study of brain abnormalities and clinical correlates in post treatment Lyme disease. | 2022 | PloS one | Europe PMC; Preprint (medRxiv/bioRxiv); PubMed | nan |
| PMID:36329513.0 | Efficacy and safety of Treamid in the rehabilitation of patients after COVID-19 pneumonia: a phase 2, randomized, double-blind, placebo-controlled trial. | 2022 | Journal of translational medicine | Preprint (medRxiv/bioRxiv); PubMed | nan |
| PMID:36410797.0 | HEART rate variability biofeedback for long COVID symptoms (HEARTLOC): protocol for a feasibility study. | 2022 | BMJ open | Europe PMC; Preprint (medRxiv/bioRxiv); PubMed | NCT05228665 |
| PMID:36494693.0 | A comparison of health-related factors between patients diagnosed with ME/CFS and patients with a related symptom picture but no ME/CFS diagnosis: a cross-sectional exploratory study. | 2022 | Journal of translational medicine | Europe PMC; Preprint (medRxiv/bioRxiv); PubMed | nan |
| PMID:36517845.0 | Genetic risk factors for ME/CFS identified using combinatorial analysis. | 2022 | Journal of translational medicine | Europe PMC; OpenAlex; Preprint (medRxiv/bioRxiv); PubMed | nan |
| PMID:36553962.0 | What Primary Care Practitioners Need to Know about the New NICE Guideline for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome in Adults. | 2022 | Healthcare (Basel, Switzerland) | Europe PMC; Preprint (medRxiv/bioRxiv); PubMed | nan |
| PMID:36993570.0 | Genipin Crosslinks the Extracellular Matrix to Rescue Developmental and Degenerative Defects, and Accelerates Regeneration of Peripheral Neurons. | 2023 | bioRxiv : the preprint server for biology | Preprint (medRxiv/bioRxiv); PubMed | nan |
| PMID:37903840.0 | Reduction of retinal ganglion cell death in mouse models of familial dysautonomia using AAV-mediated gene therapy and splicing modulators. | 2023 | Scientific reports | Europe PMC; Preprint (medRxiv/bioRxiv); PubMed | nan |
| PMID:37425897.0 | Increased circulating fibronectin, depletion of natural IgM and heightened EBV, HSV-1 reactivation in ME/CFS and long COVID. | 2023 | medRxiv : the preprint server for health sciences | Preprint (medRxiv/bioRxiv); PubMed | nan |
| PMID:37582801.0 | Co-creation of a complex, multicomponent rehabilitation intervention and feasibility trial protocol for the PostUraL tachycardia Syndrome Exercise (PULSE) study. | 2023 | Pilot and feasibility studies | Europe PMC; OpenAlex; Preprint (medRxiv/bioRxiv); PubMed | nan |
| PMID:37653608.0 | Developing a Blood Cell-Based Diagnostic Test for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Using Peripheral Blood Mononuclear Cells. | 2023 | Advanced science (Weinheim, Baden-Wurttemberg, Germany) | Europe PMC; Preprint (medRxiv/bioRxiv); PubMed | nan |
| PMID:37685544.0 | The Potential Role of Hypothalamic Phospholipid Liposomes in the Supportive Therapy of Some Manifestations of Post-COVID-19 Condition: Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) and Brain Fog. | 2023 | Journal of clinical medicine | Europe PMC; OpenAlex; Preprint (medRxiv/bioRxiv); PubMed | nan |
| PMID:37693468.0 | Dysregulation of extracellular vesicle protein cargo in female ME/CFS cases and sedentary controls in response to maximal exercise. | 2023 | bioRxiv : the preprint server for biology | Preprint (medRxiv/bioRxiv); PubMed | nan |
| PMID:37804660.0 | Low-dose naltrexone use for the management of post-acute sequelae of COVID-19. | 2023 | International immunopharmacology | Europe PMC; OpenAlex; Preprint (medRxiv/bioRxiv); PubMed | nan |
| PMID:37834888.0 | Effect of Water-Based vs. Land-Based Exercise Intervention (postCOVIDkids) on Exercise Capacity, Fatigue, and Quality of Life in Children with Post COVID-19 Condition: A Randomized Controlled Trial. | 2023 | Journal of clinical medicine | Europe PMC; Preprint (medRxiv/bioRxiv); PubMed | nan |
| PMID:37881452.0 | Typing myalgic encephalomyelitis by infection at onset: A DecodeME study. | 2023 | NIHR open research | Europe PMC; Preprint (medRxiv/bioRxiv); PubMed | nan |
| PMID:37915075.0 | Genetic risk factors for severe and fatigue dominant long COVID and commonalities with ME/CFS identified by combinatorial analysis. | 2023 | Journal of translational medicine | Europe PMC; Preprint (medRxiv/bioRxiv); PubMed | nan |
| PMID:37919310.0 | Treatment of 95 post-Covid patients with SSRIs. | 2023 | Scientific reports | Europe PMC; OpenAlex; Preprint (medRxiv/bioRxiv); PubMed | nan |
| PMID:38075920.0 | Superior efficacy of combination antibiotic therapy versus monotherapy in a mouse model of Lyme disease. | 2023 | Frontiers in microbiology | Europe PMC; Preprint (medRxiv/bioRxiv); PubMed | nan |
| PMID:38202282.0 | Immunological Patient Stratification in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome. | 2024 | Journal of clinical medicine | Europe PMC; Preprint (medRxiv/bioRxiv); PubMed | nan |
| PMID:38203745.0 | Mitochondrial Dysfunction and Coenzyme Q10 Supplementation in Post-Viral Fatigue Syndrome: An Overview. | 2024 | International journal of molecular sciences | Europe PMC; OpenAlex; Preprint (medRxiv/bioRxiv); PubMed | nan |
| PMID:38549668.0 | Impact of treatment adherence and inhalation technique on asthma outcomes of pediatric patients: a longitudinal study. | 2024 | Frontiers in pharmacology | Europe PMC; Preprint (medRxiv/bioRxiv); PubMed | nan |
| PMID:38562707.0 | Subjective and Objective Measures of Cognitive Function are Correlated in Persons with Post-COVID-19 Condition: A Secondary Analysis of a Randomized Controlled Trial. | 2024 | medRxiv : the preprint server for health sciences | Europe PMC; Preprint (medRxiv/bioRxiv); PubMed | nan |
| PMID:38562760.0 | Greater Role of Cognitive Impairment Over Fatigue in Post-COVID-19 Quality of Life: A Post-Hoc Analysis of a Randomized Controlled Trial. | 2024 | medRxiv : the preprint server for health sciences | Preprint (medRxiv/bioRxiv); PubMed | nan |
| PMID:38585862.0 | Palmitoylation regulates norepinephrine transporter trafficking and expression and is potentially involved in the pathogenesis of postural orthostatic tachycardia syndrome. | 2024 | bioRxiv : the preprint server for biology | Preprint (medRxiv/bioRxiv); PubMed | nan |
| PMID:40627396.0 | Oxidative stress is a shared characteristic of ME/CFS and Long COVID. | 2025 | Proceedings of the National Academy of Sciences of the United States of America | Europe PMC; Preprint (medRxiv/bioRxiv); PubMed | nan |
| PMID:38892879.0 | The German Multicenter Registry for ME/CFS (MECFS-R). | 2024 | Journal of clinical medicine | Europe PMC; Preprint (medRxiv/bioRxiv); PubMed | nan |
| PMID:38979186.0 | BioMapAI: Artificial Intelligence Multi-Omics Modeling of Myalgic Encephalomyelitis / Chronic Fatigue Syndrome. | 2025 | bioRxiv : the preprint server for biology | Preprint (medRxiv/bioRxiv); PubMed | nan |
| PMID:39018686.0 | A pilot randomized controlled trial of major ozone autohemotherapy for patients with post-acute sequelae of COVID-19. | 2024 | International immunopharmacology | Europe PMC; OpenAlex; Preprint (medRxiv/bioRxiv); PubMed | nan |
| PMID:39040197.0 | Long COVID Brain Fog Treatment: Findings from a Pilot Randomized Controlled Trial of Constraint-Induced Cognitive Therapy. | 2024 | medRxiv : the preprint server for health sciences | Preprint (medRxiv/bioRxiv); PubMed | nan |
| PMID:39042711.0 | The mechanism of mammalian proton-coupled peptide transporters. | 2024 | eLife | Europe PMC; Preprint (medRxiv/bioRxiv); PubMed | nan |
| PMID:39071772.0 | Resonant breathing improves self-reported symptoms and wellbeing in people with Long COVID. | 2024 | Frontiers in rehabilitation sciences | Europe PMC; Preprint (medRxiv/bioRxiv); PubMed | nan |
| PMID:39407877.0 | How Long Is Long COVID? Evaluation of Long-Term Health Status in Individuals Discharged from a Specialist Community Long COVID Service. | 2024 | Journal of clinical medicine | Europe PMC; Preprint (medRxiv/bioRxiv); PubMed | nan |
| PMID:39434179.0 | Telehealth-delivered cognitive rehabilitation for people with cognitive impairment as part of the post-COVID syndrome: protocol for a randomised controlled trial as part of the CICERO (Cognitive Impairment in Long COVID: | 2024 | Trials | Europe PMC; Preprint (medRxiv/bioRxiv); PubMed | NCT05731570 |
| PMID:39598315.0 | Spinal Neuromodulation for Respiratory Rehabilitation in Patients with Post-Acute COVID-19 Syndrome. | 2024 | Life (Basel, Switzerland) | Europe PMC; Preprint (medRxiv/bioRxiv); PubMed | nan |
| PMID:39651221.0 | Engineered CRISPR-Base Editors as a Permanent Treatment for Familial Dysautonomia. | 2024 | bioRxiv : the preprint server for biology | Preprint (medRxiv/bioRxiv); PubMed | nan |
| PMID:39767601.0 | Pharmacotherapy from Pre-COVID to Post-COVID: Longitudinal Trends and Predictive Indicators for Long COVID Symptoms. | 2024 | Biomedicines | Europe PMC; Preprint (medRxiv/bioRxiv); PubMed | nan |
| PMID:39964606.0 | The genetic landscape of pediatric postural orthostatic tachycardia syndrome. | 2025 | Clinical autonomic research : official journal of the Clinical Autonomic Research Society | Europe PMC; Preprint (medRxiv/bioRxiv); PubMed | nan |
| PMID:39996021.0 | A network medicine approach to investigating ME/CFS pathogenesis in severely ill patients: a pilot study. | 2025 | Frontiers in human neuroscience | Europe PMC; Preprint (medRxiv/bioRxiv); PubMed | nan |
| PMID:40143349.0 | Prevalence of EBV, HHV6, HCMV, HAdV, SARS-CoV-2, and Autoantibodies to Type I Interferon in Sputum from Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Patients. | 2025 | Viruses | Europe PMC; Preprint (medRxiv/bioRxiv); PubMed | nan |
| PMID:40259275.0 | Unequal access to diagnosis of myalgic encephalomyelitis in England. | 2025 | BMC public health | Europe PMC; Preprint (medRxiv/bioRxiv); PubMed | nan |
| PMID:40338225.0 | HERV activation segregates ME/CFS from fibromyalgia while defining a novel nosologic entity. | 2025 | eLife | Europe PMC; Preprint (medRxiv/bioRxiv); PubMed | nan |
| PMID:40492086.0 | Time-Restricted Eating Improves Quality of Life, Heart Rate, and Mitochondrial Function in Patients with Postural Orthostatic Tachycardia Syndrome. | 2025 | medRxiv : the preprint server for health sciences | Preprint (medRxiv/bioRxiv); PubMed | nan |
| PMID:40627388.0 | Patient-reported treatment outcomes in ME/CFS and long COVID. | 2025 | Proceedings of the National Academy of Sciences of the United States of America | Europe PMC; OpenAlex; Preprint (medRxiv/bioRxiv); PubMed | nan |
Articles tend to lag trial registrations by 2–3 years. A peak in trial starts without a corresponding wave of publications is the dark-trial signal — studies registered but not yet reported.
Of 312 completed trials, 221 (71%) have no linked publication in our corpus. This is the most actionable gap: completed trials that should have results, where evidence may be sitting in journal pipelines, conference abstracts, or unpublished. Recruiting and active trials have no expected publications yet, so their high unlinked rate is normal.
| NCT ID | Title | Completed | Sponsor | Intervention |
|---|---|---|---|---|
| NCT06404099 | RECOVER-SLEEP: A Platform Protocol for Evaluation of Interventions for Sleep Disturbances in Post-Acute Sequelae of SARS | 2026-04-20 | Duke University | Modafinil; Modafinil Placebo; Solriamfetol; Solriamfetol Pla |
| NCT06723821 | Effectiveness of Noninvasive Neuromodulation in Post-COVID Musculoskeletal Pain in the Short Term: Randomized Clinical T | 2026-04-15 | University of Alcala | Neuromodulation group; Neuromodulation sham group |
| NCT06223971 | A Phase l Study to Assess the Safety and Tolerability of PET Imaging With [11 C]CPPC [5-cyano-N-( 4-( 4-[l l CJ me1hylpi | 2026-03-31 | Johns Hopkins University | [11C]CPPC Injection; [11C]CPPC Injection |
| NCT06404112 | RECOVER-SLEEP: A Platform Protocol for Evaluation of Interventions for Sleep Disturbances in Post-Acute Sequelae of SARS | 2026-03-27 | Duke University | Melatonin; Melantonin Placebo; Tailored lighting (TL) Active |
| NCT06503874 | Intensive Attention Training to Treat Brain Fog in Individuals With Long-Covid | 2026-03-13 | Shirley Ryan AbilityLab | Attention Training; Music Group |
| NCT06503913 | Cognitive Muscular Therapy for Patients With Long-COVID (Post COVID-19) and Breathing Pattern Disorder | 2026-03-01 | University of Salford | Cognitive Muscular Therapy; Breathing visualisation |
| NCT05430152 | A Double Blind Randomized Trial of Low-dose Naltrexone for Post-COVID Fatigue Syndrome | 2026-02-28 | Luis Nacul | Low-Dose Naltrexone; Placebo |
| NCT07182578 | Programming Aquatic Therapy for POTS | 2026-02-08 | California State University, Dominguez Hills | Aquatic Occupational Therapy |
| NCT06404086 | RECOVER-SLEEP: A Platform Protocol for Evaluation of Interventions for Sleep Disturbances in Post-Acute Sequelae of SARS | 2025-12-31 | Duke University | Modafinil; Modafinil Placebo; Solriamfetol; Solriamfetol Pla |
| NCT05513560 | REcovering From COVID-19 Lingering Symptoms Adaptive Integrative Medicine (RECLAIM) | 2025-12-31 | University Health Network, Toronto | Ibudilast; Pentoxifylline; Placebo |
Coverage of Post-COVID, ME/CFS, post-viral, and related conditions across the corpus, split by trials and articles.
| NCT ID | Title | Status | Phase | Sponsor | Intervention |
|---|---|---|---|---|---|
| NCT04141696 | A Proof-of-Concept Trial on the Effect of Ketamine on Fatigue | COMPLETED | PHASE1; PHASE2 | National Institute of Nursing Research (NINR) | Ketamine; Midazolam |
| NCT03674541 | The Exercise Response to Pharmacologic Cholinergic Stimulation in Myalgic Encephalomyelitis / Chronic Fatigue Syndrome | COMPLETED | PHASE2 | Brigham and Women's Hospital | Pyridostigmine Bromide; Placebo |
| NCT05608629 | Vagus Nerve Stimulation as Treatment for Long Covid | COMPLETED | nan | Icahn School of Medicine at Mount Sinai | Transcutaneous Non-Invasive Vagus Nerve Stimulation |
| NCT05200858 | Transcutaneous Electrical Nerve Stimulation For Lower Extremity In Patients With Neurogenic Pain - A Proof Of Concept Randomized Clinical Trial | COMPLETED | nan | Baylor College of Medicine | TENS - high-dose; TENS - low-dose |
| NCT04313972 | IC PaIN Trial: Interstitial Cystitis Pain Improvement With Naltrexone, the Effect of Low Dose Naltrexone on Symptoms and Pain of Patients With Interstitial Cystitis/Painful Bladder | TERMINATED | PHASE4 | Endeavor Health | low-dose naltrexone; Placebo oral tablet |
| NCT05638633 | Prednisolone and Vitamin B1, B6, and B12 in Patients With Post-COVID-19-Syndrome (PC19S) - a Randomized Controlled Trial in Primary Care | COMPLETED | PHASE3 | Wuerzburg University Hospital | Prednisolone 20 mg/ 5 mg; Vitamin B compound (100mg B1, 50 mg B6, 500 µg B12); Placebo for Vitamin B compound; Placebo for Prednisolon |
| NCT05939622 | Prospective Randomized Double Blind Placebo Controlled Study of Efficacy of the Therapy With BRAINMAX® Using Functional Magnetic Resonance Imaging (fMRI) for the Treatment of Patie | COMPLETED | PHASE4 | Promomed, LLC | Structural and functional MRI; Ethyl methyl hydroxypyridine succinate + Meldonium; Placebo |
| NCT04622293 | A Double-Blind, Randomized, Placebo-Controlled, Single-Center, Flexible Titration Study Evaluating the Efficacy of Solriamfetol in Treating Fatigue and Cognitive Symptoms in Adults | COMPLETED | PHASE4 | Rochester Center for Behavioral Medicine | Solriamfetol Oral Tablet [Sunosi]; Placebo |
| NCT06245642 | A Multi-center, Randomized, Double-blind, Positive Parallel Control Study of Compound Ciwujia Granules in the Treatment of Chronic Fatigue Syndrome (Spleen-kidney Deficiency Syndro | COMPLETED | PHASE4 | Heilongjiang Quanle Pharmaceutical Co., Ltd. | Compound Ciwujia Granules, Guipi Granules |
| NCT05642923 | Post-COVID-19 Chronic Fatigue Syndrome | COMPLETED | PHASE4 | ClinAmygate | Synthetic Vitamin B1 |
| NCT06128967 | An Adaptive, Randomized, doublE-blind, Placebo-controlled, Prospective, Pharmacological interVention Study In Participants With Long COVID-19 Syndrome: REVIVE-TOGETHER Trial | COMPLETED | PHASE3 | Cardresearch | Fluvoxamine Maleate 100 MG; Placebo; Metformin Extended Release Oral Tablet |
| NCT05430152 | A Double Blind Randomized Trial of Low-dose Naltrexone for Post-COVID Fatigue Syndrome | COMPLETED | PHASE2 | Luis Nacul | Low-Dose Naltrexone; Placebo |
| NCT06596161 | Effect or Iron Therapy on Fatigue Symptoms in Non-anemic Iron Deficient Women of Reproductive Age | COMPLETED | nan | Central Park Medical College | Iron sucrose; Placebo |
| NCT06721949 | Taurine Supplementation as a Novel Therapeutic Approach for Neurocognitive Symptoms in Long COVID | RECRUITING | PHASE2; PHASE3 | University of Alberta | Taurine; Placebo |
| NCT05196529 | Inspiratory Muscle Training in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) and COVID-19 Survivors | COMPLETED | nan | York University | Inspiratory muscle training |
| NCT05840237 | REGAIN: A Randomized, Double Blind, Placebo Controlled Trial to Determine the Effects of Oxaloacetate on Improving Fatigue in Long COVID | COMPLETED | nan | Terra Biological LLC | Anhydrous Enol-Oxaloacetate, a "Medical Food"; White Rice Flour |
| NCT05728918 | Effectiveness of Antrodia Cinnamomea Mycelia on Improving Immune Response in Subhealth People | COMPLETED | nan | Greenyn Biotechnology Co., Ltd. | Antrodia cinnamomea mycelia; Placebo |
| NCT05973136 | A Pilot Study to Evaluate the Implantation and the Impact of a Hybrid Telerehabilitation Program Based on Cardiopulmonary Rehabilitation Principles for People With Post-COVID Affec | COMPLETED | nan | Université de Sherbrooke | Telerehabilitation program based on cardiorespiratory principles |
| NCT05710770 | Double-blinded, Randomized, Sham-controlled Trial of Immunoadsorption (IA) in Patients With Chronic Fatigue Syndrome (CFS) Including Patients With Post-acute COVID-19 CFS (PACS-CFS | COMPLETED | nan | Charite University, Berlin, Germany | Immunoadsorption |
| NCT04308278 | Randomized, Placebo-controlled, Double Blind Study to Evaluate the Efficacy of 2LEBV® and 2LXFS® on Asthenia in Patients With an Epstein-Barr Virus Infection. | RECRUITING | PHASE4 | Labo'Life | 2LEBV® / 2LXFS®; Placebo |
| NCT06393790 | Health Effects of a Strength Training Protocol in Women With Fibromyalgia and Healthy Individuals. | COMPLETED | nan | Catholic University of Murcia | FMG (Fibromyalgia group); HG (Healthy group) |
| NCT05630378 | Evaluation of a Multimodal Integrative Medicine and Naturopathy Program in an Outpatient Setting With Focus on Mind-Body Medicine and Mild Water-filtered Infrared-A Whole-body Hype | COMPLETED | nan | Universität Duisburg-Essen | outpatient clinic with multimodal integrative medicine and naturopathy for post-COVID-19 patients; waiting group |
| NCT04845737 | Evaluation of the Relationship Between Electrophysiological Findings With Vitamin D Levels and Inflammatory Parameters in Fibromyalgia Patients | COMPLETED | nan | Abant Izzet Baysal University | sympathetic skin response measurement |
| NCT05273372 | A Randomized Double Blind Placebo Controlled Trial to Determine the Effects of Oxaloacetate on Improving Fatigue in ME/CFS | COMPLETED | nan | Terra Biological LLC | Placebo; Medical Food - Anhydrous Enol-Oxaloacetate |
| NCT07301580 | Physical Prehabilitation of Breast Cancer-Related Lymphedema | COMPLETED | nan | University of Health Sciences Balikesir Hospital Eduation and Research | Prehabilitation Exercise Group |
| NCT05803824 | Efficacy of Baduanjin Qigong Exercise Program on Fatigue and Postural Imbalance Following Lower Limb Burn Injury | COMPLETED | nan | Cairo University | exercise therapy program |
| NCT05697640 | A Parallel-group Treatment, Phase 2a, Double-blind, Placebo-controlled 2-arm Study to Show Improvement of Physical Function in SF-36 (SF-36-PF) in Participants Treated With Vericig | ACTIVE_NOT_RECRUITING | PHASE2 | Charite University, Berlin, Germany | Vericiguat Oral Tablet |
| NCT04381780 | Treatment of Fibromyalgia With a Unique Polypeptide Nutritional Support | COMPLETED | nan | Practitioners Alliance Network | Recovery Factors |
| NCT05841498 | A Single-blinded Sham-controlled Crossover Trial to Evaluate the Effect of Immunoadsorption on Post-Corona Virus Disease (COVID)-Syndrome | COMPLETED | nan | University Medical Center Mainz | Immunoadsorption; Sham-apheresis |
| NCT06341751 | Psychological Treatment for Persistent Fatigue: a Feasibility Study | COMPLETED | nan | Karolinska Institutet | Psychological treatment for persistent fatigue |
| NCT07524179 | The Effect of Therapeutic Touch on Sleep Quality and Fatigue Severity in Advanced Cancer Patients in the Palliative Care Setting: A Randomized Controlled Trial | COMPLETED | nan | Erzurum Technical University | Therapeutic Touch; Routine Palliative Care |
| NCT04740736 | Cardiovascular Analysis of Post-exertional Malaise | COMPLETED | nan | Icahn School of Medicine at Mount Sinai | Saline Infusion |
| NCT05664711 | Effect of Stellate Ganglion Block on ME/CFS Symptoms and Metabolites | COMPLETED | PHASE1 | Neuroversion, Inc. | Bupivacaine Injection |
| NCT04833673 | The Effects of Relaxation Techniques on Pain, Fatigue and Kinesiophobia in Multiple Sclerosis Patients: A Three Arms Randomized Trial | COMPLETED | nan | Hacettepe University | PMR: Progressive Muscle Relaxation; BRT:Benson Relaxation Technique |
| NCT07455123 | The Effect of a Self-Management Program on Fatigue, Sleep Quality, Psychological Resilience, and Occupational Balance in University Students With High Levels of Fatigue: A Randomiz | COMPLETED | nan | Hacettepe University | Self-Management Programme for Chronic Fatigue |
| NCT06635928 | Assessing Fatigue and Attention in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Patients Before and After Treatment With Bright Light Therapy: a Prospective Randomized Contro | COMPLETED | nan | Medical University of Vienna | Bright light therapy |
| NCT04378634 | The Influence of Epigenetic Modifications and Post-Exertional Malaise in People With Myalgic Encephalomyelitis/Chronic Fatigue Syndrome | COMPLETED | nan | Vrije Universiteit Brussel | Exercise; Mental Stress Test |
| NCT06575920 | Breathing Therapy for Patients With Medically Unexplained Physical Symptoms and Dysfunctional Breathing: A Pilot and Feasibility Study | COMPLETED | nan | University of Agder | Breathing excercizes |
| NCT04741841 | Effect of Probiotic Food Supplement "GutMagnific™" in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS), Also Known as Post-viral Fatigue Syndrome, and Comorbid | COMPLETED | nan | ImmuneBiotech Medical Sweden AB | GutMagnific™ H.; GutMagnific™ L.; Placebo |
| NCT04158427 | Intestinal Microbiota and Chronic Fatigue Syndrome. Effect of Fecal Transplant on Health Related Quality of Life of the Patients With Chronic Fatigue Syndrome | COMPLETED | nan | Tampere University Hospital | Faecal transplantation; Placebo faecal transplantation |
| NCT04049331 | Improving Patient-Important Outcomes With Testosterone Replacement in Hypogonadal Men With a Prior History of Cancer | ACTIVE_NOT_RECRUITING | PHASE2 | Seattle Institute for Biomedical and Clinical Research | Testosterone Undecanoate 750 MG/3 ML Intramuscular Solution [AVEED]; placebo |
| NCT06172803 | RESToRE: Restoring Energy With Sub-symptom Threshold Optimized Rehabilitation Exercise for Long COVID | COMPLETED | nan | Columbia University | Restoring Energy with Sub-symptom Threshold Aerobic Rehabilitation Exercise; Light Stretching/Breathing Exercises |
| NCT07057999 | Effects of the MIND Diet on Fatigue, Quality of Life, and Brain Fog in Patients With Multiple Sclerosis: A Randomized Controlled Trial | COMPLETED | nan | Betul Uner | MIND Diet (Mediterranean-DASH Intervention for Neurodegenerative Delay); Traditional healthy nutrition program specific to Turkey |
| NCT05507190 | Self-management of Post COVID-19 Syndrome Using Wearable Biometric Technology | COMPLETED | nan | University of Manitoba | Self-management of post COVID-19 respiratory outcomes |
| NCT05954325 | Extracorporal Apheresis Hannover Medical School Study in Post COVID-19 Patients | COMPLETED | nan | Hannover Medical School | Immunoadsorption vs. sham immunoadsorption |
| NCT06064838 | Effects of Cacao Flavonoids in Long COVID-19 Patients with Chronic Fatigue (FLALOC) | COMPLETED | nan | Guillermo Ceballos Reyes | Flavonoids |
| NCT05765591 | Effects of Balneotherapy for Patients With Post-COVID Syndrome | COMPLETED | nan | Parc de Salut Mar | Balneotherapy and aquatic exercises |
| NCT05172206 | Symptom-based Rehabilitation Compared to Usual Care in Post-COVID - a Randomized Controlled Trial | COMPLETED | nan | Schön Klinik Berchtesgadener Land | symptom-focused rehabilitation; usual care |
| NCT07263854 | Effects of Lower Extremity Neuromuscular Facilitation on Gait, Balance and Fatigue in Patients With Multiple Sclerosis: A Randomized Controlled Study | COMPLETED | nan | Sanko University | exercises |
| NCT05658536 | The COPE Study: Pilot Intervention to Improve Symptom Self-management and Coping in Adults With Post COVID | COMPLETED | nan | University of Washington | 6-Week Self-Management Group |
| ID | Title | Year | Journal | Source | Linked NCTs |
|---|---|---|---|---|---|
| PMID:30325677.0 | Guided graded Exercise Self-help for chronic fatigue syndrome: patient experiences and perceptions. | 2020 | Disability and rehabilitation | PubMed | nan |
| PMID:30380922.0 | Feedback on underperformance in patients with Chronic Fatigue Syndrome: The impact on subsequent neuropsychological test performance. | 2020 | Applied neuropsychology. Adult | PubMed | nan |
| PMID:30455072.0 | Antioxidant and immunomodulatory properties of Spilanthes oleracea with potential effect in chronic fatigue syndrome infirmity. | 2020 | Journal of Ayurveda and integrative medicine | PubMed | nan |
| PMID:30655187.0 | Hypophosphatasia in Adults: Clinical Spectrum and Its Association With Genetics and Metabolic Substrates. | 2020 | Journal of clinical densitometry : the official journal of the International Society for Clinical De | PubMed | nan |
| PMID:31113527.0 | Psychometric properties of the Cognitive and Behavioural Responses Questionnaire (CBRQ) in adolescents with chronic fatigue syndrome. | 2020 | Behavioural and cognitive psychotherapy | PubMed | nan |
| PMID:31234662.0 | Monitoring treatment harm in myalgic encephalomyelitis/chronic fatigue syndrome: A freedom-of-information study of National Health Service specialist centres in England. | 2021 | Journal of health psychology | PubMed | nan |
| PMID:31407924.0 | How do women suffering from multiple chemical sensitivity experience the medical encounter? a qualitative study in Spain. | 2021 | Disability and rehabilitation | PubMed | nan |
| PMID:31461628.0 | Brain Responses in CFS and TMD to Autonomic Challenges: An Exploratory fMRI Study. | 2020 | JDR clinical and translational research | PubMed | nan |
| PMID:31483181.0 | Is the efficacy of repetitive transcranial magnetic stimulation influenced by baseline severity of fatigue symptom in patients with myalgic encephalomyelitis. | 2020 | The International journal of neuroscience | PubMed | NCT07278206 |
| PMID:31669858.0 | News and views in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS): The role of co-morbidity and novel treatments. | 2020 | Medical hypotheses | PubMed | nan |
| PMID:31794439.0 | A MAPP Network Case-control Study of Urological Chronic Pelvic Pain Compared With Nonurological Pain Conditions. | 2020 | The Clinical journal of pain | PubMed | nan |
| PMID:31826926.0 | Conceptualising illness and disease: reflections on Sharpe and Greco (2019). | 2020 | Medical humanities | PubMed | nan |
| PMID:31830003.0 | Myalgic encephalomyelitis/chronic fatigue syndrome patients exhibit altered T cell metabolism and cytokine associations. | 2020 | The Journal of clinical investigation | PubMed | NCT05273372; NCT05664711 |
| PMID:31840339.0 | Can linguistic analysis be used to identify whether adolescents with a chronic illness are depressed? | 2020 | Clinical psychology & psychotherapy | PubMed | nan |
| PMID:31884303.0 | Post-exertional malaise is associated with greater symptom burden and psychological distress in patients diagnosed with Chronic Fatigue Syndrome. | 2020 | Journal of psychosomatic research | PubMed | nan |
| PMID:31902915.0 | Neuroinflammation, Oxidative Stress, and Neurogenesis in a Mouse Model of Chronic Fatigue Syndrome, and the Treatment with Kampo Medicine. | 2020 | Biological & pharmaceutical bulletin | PubMed | nan |
| PMID:31923274.0 | Metabolic analysis of amino acids and vitamin B6 pathways in lymphoma survivors with cancer related chronic fatigue. | 2020 | PloS one | PubMed | nan |
| PMID:31957647.0 | Parasympathetic activity is reduced during slow-wave sleep, but not resting wakefulness, in patients with chronic fatigue syndrome. | 2020 | Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Me | PubMed | nan |
| PMID:32020880.0 | Treating medically unexplained symptoms via improving access to psychological therapy (IAPT): major limitations identified. | 2020 | BMC psychology | PubMed | nan |
| PMID:32021614.0 | Prevalence and treatment of Chronic Fatigue Syndrome/Myalgic Encephalomyelitis and co-morbid severe health anxiety. | 2020 | International journal of clinical and health psychology : IJCHP | PubMed | nan |
| PMID:32140630.0 | Cerebral blood flow is reduced in ME/CFS during head-up tilt testing even in the absence of hypotension or tachycardia: A quantitative, controlled study using Doppler echography. | 2020 | Clinical neurophysiology practice | Europe PMC; PubMed | nan |
| PMID:32171889.0 | Complex syndromes of chronic pain, fatigue and cognitive impairment linked to autoimmune dysautonomia and small fiber neuropathy. | 2020 | Clinical immunology (Orlando, Fla.) | Europe PMC; PubMed | nan |
| PMID:32247028.0 | A Unifying Hypothesis of the Pathophysiology of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS): Recognitions from the finding of autoantibodies against ß2-adrenergic receptors. | 2020 | Autoimmunity reviews | PubMed | NCT05664711 |
| PMID:32248536.0 | Chronic fatigue syndrome: progress and possibilities. | 2020 | The Medical journal of Australia | PubMed | nan |
| PMID:32256619.0 | The presence of overlapping quality of life symptoms in primary antibody deficiency (PAD) and chronic fatigue syndrome (CFS). | 2020 | Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and C | PubMed | nan |
| PMID:32256939.0 | International expert consensus on the management of allergic rhinitis (AR) aggravated by air pollutants: Impact of air pollution on patients with AR: Current knowledge and future strategies. | 2020 | The World Allergy Organization journal | PubMed | nan |
| PMID:32272608.0 | The Development of a Consistent Europe-Wide Approach to Investigating the Economic Impact of Myalgic Encephalomyelitis (ME/CFS): A Report from the European Network on ME/CFS (EUROMENE). | 2020 | Healthcare (Basel, Switzerland) | PubMed | nan |
| PMID:32327453.0 | Human Herpesvirus-6 Reactivation, Mitochondrial Fragmentation, and the Coordination of Antiviral and Metabolic Phenotypes in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome. | 2020 | ImmunoHorizons | PubMed | nan |
| PMID:32335457.0 | The importance of contextual aspects in the care for patients with functional somatic symptoms. | 2020 | Medical hypotheses | PubMed | nan |
| PMID:32342016.0 | Cognitive-behavioural therapy combined with music therapy for chronic fatigue following Epstein-Barr virus infection in adolescents: a feasibility study. | 2020 | BMJ paediatrics open | PubMed | nan |
| PMID:32361726.0 | Treatment outcome in adults with chronic fatigue syndrome: a prospective study in England based on the CFS/ME National Outcomes Database. | 2023 | QJM : monthly journal of the Association of Physicians | PubMed | nan |
| PMID:32380660.0 | The Effect of Parenteral or Oral Iron Supplementation on Fatigue, Sleep, Quality of Life and Restless Legs Syndrome in Iron-Deficient Blood Donors: A Secondary Analysis of the IronWoMan RCT. | 2020 | Nutrients | PubMed | nan |
| PMID:32411717.0 | Intravenous Cyclophosphamide in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome. An Open-Label Phase II Study. | 2020 | Frontiers in medicine | Europe PMC; OpenAlex; PubMed | nan |
| PMID:32426159.0 | The feasibility and acceptability of an early intervention in primary care to prevent chronic fatigue syndrome (CFS) in adults: randomised controlled trial. | 2020 | Pilot and feasibility studies | OpenAlex; PubMed | nan |
| PMID:32441119.0 | Sleep problems in adolescents with CFS: A case-control study nested within a prospective clinical cohort. | 2020 | Clinical child psychology and psychiatry | PubMed | nan |
| PMID:32450339.0 | The role of partners' fatigue and the patient-partner relationship in the outcome of cognitive behavioural therapy for chronic fatigue syndrome. | 2020 | Journal of psychosomatic research | PubMed | nan |
| PMID:32450550.0 | Eradication of persistent coxsackievirus B infection from a pancreatic cell line with clinically used antiviral drugs. | 2020 | Journal of clinical virology : the official publication of the Pan American Society for Clinical Vir | PubMed | nan |
| PMID:32459909.0 | [Spinach and quinoa - prospective food sources of biologically active substances]. | 2020 | Voprosy pitaniia | PubMed | nan |
| PMID:32470498.0 | Mitochondria and immunity in chronic fatigue syndrome. | 2020 | Progress in neuro-psychopharmacology & biological psychiatry | PubMed | nan |
| PMID:32482748.0 | The concept of 'illness without disease' impedes understanding of chronic fatigue syndrome: a response to Sharpe and Greco. | 2021 | Medical humanities | PubMed | nan |
| PMID:32488281.0 | Preliminary ICF core set for patients with myalgic encephalomyelitis/chronic fatigue syndrome in rehabilitation medicine. | 2020 | Journal of rehabilitation medicine | PubMed | nan |
| PMID:32503553.0 | Health-related quality of life in Norwegian adolescents living with chronic fatigue syndrome. | 2020 | Health and quality of life outcomes | PubMed | nan |
| PMID:32504895.0 | Patterns of daytime physical activity in patients with chronic fatigue syndrome. | 2020 | Journal of psychosomatic research | PubMed | nan |
| PMID:32506340.0 | Protective Effect of Hemin Against Experimental Chronic Fatigue Syndrome in Mice: Possible Role of Neurotransmitters. | 2020 | Neurotoxicity research | PubMed | nan |
| PMID:32522264.0 | Predicting GP visits: A multinomial logistic regression investigating GP visits amongst a cohort of UK patients living with Myalgic encephalomyelitis. | 2020 | BMC family practice | PubMed | nan |
| PMID:32545797.0 | Cerebral Blood Flow Is Reduced in Severe Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Patients During Mild Orthostatic Stress Testing: An Exploratory Study at 20 Degrees of Head-Up Tilt Testing. | 2020 | Healthcare (Basel, Switzerland) | PubMed | nan |
| PMID:32568143.0 | Post-exertional symptoms distinguish Myalgic Encephalomyelitis/Chronic Fatigue Syndrome subjects from healthy controls. | 2020 | Work (Reading, Mass.) | OpenAlex; PubMed | nan |
| PMID:32568144.0 | Clinically accessible tools for documenting the impact of orthostatic intolerance on symptoms and function in ME/CFS. | 2020 | Work (Reading, Mass.) | PubMed | nan |
| PMID:32568148.0 | Research update: The relation between ME/CFS disease burden and research funding in the USA. | 2020 | Work (Reading, Mass.) | PubMed | nan |
| PMID:32568149.0 | Graded exercise therapy does not restore the ability to work in ME/CFS - Rethinking of a Cochrane review. | 2020 | Work (Reading, Mass.) | PubMed | nan |
| NCT ID | Title | Status | Phase | Sponsor | Intervention |
|---|---|---|---|---|---|
| NCT05633407 | A Phase 2 Randomized, Double-blinded, Placebo-controlled Study to Evaluate the Efficacy and Safety of Efgartigimod IV in Adult Patients With Post-COVID-19 Postural Orthostatic Tach | COMPLETED | PHASE2 | argenx | Efgartigimod; Placebo |
| NCT06133075 | Using Mirabegron to Increase Blood Pressure in Patients With Postural Orthostatic Tachycardia Syndrome | COMPLETED | PHASE2 | Cedars-Sinai Medical Center | Mirabegron 50 MG; Mirabegron 25 MG |
| NCT04977388 | Phase I/II Study of NORTHERA (DROXIDOPA) for Dysautonomia in Adult Survivors of Menkes Disease and Adults With Occipital Horn Syndrome: Double-blind Placebo-controlled Randomized C | COMPLETED | PHASE1; PHASE2 | Stephen G. Kaler, MD | Droxidopa; Placebo |
| NCT06253806 | Stellate Ganglion Block for the Treatment of COVID-19-Induced Parosmia: Double-Blinded, Placebo-Controlled Randomized Clinical Trial | COMPLETED | PHASE2 | Washington University School of Medicine | Stellate Ganglion Block; Placebo Sham Injection |
| NCT03674541 | The Exercise Response to Pharmacologic Cholinergic Stimulation in Myalgic Encephalomyelitis / Chronic Fatigue Syndrome | COMPLETED | PHASE2 | Brigham and Women's Hospital | Pyridostigmine Bromide; Placebo |
| NCT05445921 | Stellate Ganglion Block for the Treatment of COVID-19-Induced Olfactory Dysfunction: A Prospective Pilot Study | COMPLETED | PHASE1; PHASE2 | Washington University School of Medicine | Stellate Ganglion Block |
| NCT06268288 | Pilot Study--The Effects of Non-invasive Vagal Neurostimulation (nVNS) in Adolescents With Postural Orthostatic Tachycardia Syndrome (POTS) | COMPLETED | nan | Mayo Clinic | GammaCore intervention; STEPS management protocol |
| NCT06208163 | Psychoneuroimmunology as a Framework for Studying the Effects of Chiropractic Care in a Population With High Central Adiposity: a Pilot Trial | COMPLETED | nan | Life University | Chiropractic |
| NCT06524739 | Double-blind, Randomized, Placebo-controlled Phase 3 Study Evaluating Efficacy and Safety of IgPro20 (Subcutaneous Immunoglobulin, HIZENTRA®) in Post-COVID-19 Postural Orthostatic | TERMINATED | PHASE3 | CSL Behring | IgPro20; Placebo |
| NCT05946551 | Feasibility Assessment of a Decentralized Platform Adaptive Double-Blind, Randomized Controlled Trial Investigating Repurposed Drugs in the Treatment of Post-Acute Sequelae of Coro | TERMINATED | PHASE3 | Emory University | Cetirizine; Famotidine; Cetirizine Placebo; Famotidine Placebo |
| NCT05918978 | Open-Label Extension Study to Evaluate the Long-term Safety and Efficacy of Efgartigimod in Adult Patients With Post-COVID-19 Postural Orthostatic Tachycardia Syndrome (PC-POTS) Wh | TERMINATED | PHASE2 | argenx | Efgartigimod |
| NCT05096884 | Post-Acute Sequelae of Coronavirus-19 (COVID-19) With DysPnEA on ExertIon And Associated TaChycardia TrEatment Study | TERMINATED | EARLY_PHASE1 | Hackensack Meridian Health | Metoprolol Succinate |
| NCT04997395 | Safety and Tolerability of Full Spectrum Cannabidiol Dominant Medicinal Cannabis in Treating Symptoms Associated With Long COVID: A Feasibility Study | COMPLETED | PHASE2 | Bod Australia | MediCabilis Cannabis sativa 50 |
| NCT05619653 | Randomised Placebo Controlled Clinical Trial of Efficacy of MYOcardial Protection in Patients With Postacute inFLAMmatory Cardiac involvEment Due to COVID-19 | ACTIVE_NOT_RECRUITING | PHASE3 | Valentina Puentmann | Prednisolone; Losartan |
| NCT06305780 | RECOVER-AUTONOMIC: A Platform Protocol for Evaluation of Interventions for Autonomic Dysfunction in Post-Acute Sequelae of SARS-CoV-2 Infection (PASC) | COMPLETED | PHASE2 | Kanecia Obie Zimmerman | IVIG + Coordinated Care; IVIG Placebo + Coordinated Care; Ivabradine + Coordinated Care; Ivabradine Placebo + Coordinated Care; IVIG + Usual Care; IVIG Placebo |
| NCT05823896 | An Interventional, Double-Blinded, 2-Arm Study to Investigate the Efficacy of Orally Administered Nirmatrelvir/Ritonavir Compared with Placebo/Ritonavir in Non-hospitalized Adult P | COMPLETED | PHASE2 | Karolinska Institutet | Nirmatrelvir/ritonavir; Placebo/ritonavir |
| NCT04842448 | Hyperbaric Oxygen for Treatment of Long COVID Syndrome; A Randomized, Placebo-Controlled, Double-Blind, Phase II Clinical Trial | COMPLETED | PHASE2 | Karolinska University Hospital | Hyperbaric oxygen; Sham treatment |
| NCT06305806 | RECOVER-AUTONOMIC (Ivabradine): Randomized Trial of the Effect of Ivabradine Versus Placebo on Long COVID Symptoms | COMPLETED | PHASE2 | Kanecia Obie Zimmerman | Ivabradine; Ivabradine Placebo; Coordinated Care; Usual Care |
| NCT05638620 | Evaluating the Effectiveness of Dual Sympathetic Blocks for Patients Experiencing Sympathetically-Mediated Symptoms From Post-Acute Sequelae of SARS-CoV-2 (PASC) | COMPLETED | PHASE1 | Jonathann Kuo, MD | stellate ganglion block with 0.5% bupivacaine |
| NCT07029191 | SYMPA-VEIN : Pilot Study Evaluating the ACCUVEIN Superficial Vein Visualization Device for the Detection of Alterations in the Autonomic Nervous System | COMPLETED | nan | University Hospital, Angers | Progressive standing test |
| NCT07280572 | RECLAIM: an Adaptive Platform Trial for the Evaluation of Treatments for Post-Acute Sequelae of SARS-CoV-2 Infection (PASC) | ENROLLING_BY_INVITATION | PHASE3 | Janneke van de Wijgert | Metformin; colchicine |
| NCT04603157 | Remote Self-training Program for Patients With Postural Orthostatic Tachycardia Syndrome (POTS) | COMPLETED | nan | Mayo Clinic | Hybrid Exercise Training |
| NCT05469477 | Behavioral Interventions to Increase Seat Belt Wearing and Decrease Handheld Phone Use While Driving | COMPLETED | nan | University of Pennsylvania | Persuasive education; WOOP (aka, mental contrasting with implementation intentions., Wish, Outcome, Obstacle, Plan); Customized Habit Tips; Raffle Financial Inc |
| NCT06305793 | RECOVER-AUTONOMIC (IVIG): Randomized Trial of the Effect of IVIG Versus Placebo on Long COVID Symptoms | ACTIVE_NOT_RECRUITING | PHASE2 | Kanecia Obie Zimmerman | IVIG (intravenous immunoglobulin); IVIG Placebo; Coordinated Care; Usual Care |
| NCT05404672 | Effects Of Breathing Exercises With And Without Aerobic Training On Dysfunctional Breathing And Exercise Intolerance In Patients With Postural Orthostatic Tachycardia Syndrome | COMPLETED | nan | Riphah International University | Aerobic Training; Conventional Treatment |
| NCT04527198 | Brainstem Dysfunction in Ventilated and Deeply Sedated COVID-19 Critically Ill Patients: a Prospective Observational Study | COMPLETED | nan | Assistance Publique - Hôpitaux de Paris | Brainstem Responses Assessment Sedation Score (BRASS); Electroencephalogram with EKG lead |
| NCT06795750 | The Effect of Neural Therapy on Heart Rate Recovery, Cardiac Parameters and Pain in Fibromyalgia: a Randomized Controlled Trial | COMPLETED | nan | Uşak University | neural therapy; Exercise |
| NCT07238465 | Dysautonomia InVestigation in Individuals With Down SyndromE: DIVE Study | RECRUITING | PHASE3 | University of Colorado, Denver | Fear Response; Cold Stress; Pain Response; Caffeine; 12-Hour Fast; Maximal Dynamic Exercise |
| NCT05454137 | Postural Orthostatic Tachycardia Syndrome: a Pilot, Feasibility Study of an Integrative Shared Medical Appointment Intervention | COMPLETED | nan | University of Arizona | Shared medical appointment |
| NCT04170725 | Muscular and Cutaneous Dysfunction in Postural Tachycardia Syndrome | COMPLETED | nan | Insel Gruppe AG, University Hospital Bern | Patient and Healthy Volunteers training protocol |
| NCT05566379 | Effects of a Mindfulness Intervention on Physical and Psychological Well-Being and Quality of Life in Patients With Post Acute Sequelae of SARS-CoV-2 Infection (PASC) Dysautonomia | COMPLETED | nan | University of California, Los Angeles | Mindfulness - Mindful Awareness Practices ( MAPs) |
| NCT06503913 | Cognitive Muscular Therapy for Patients With Long-COVID (Post COVID-19) and Breathing Pattern Disorder | COMPLETED | nan | University of Salford | Cognitive Muscular Therapy; Breathing visualisation |
| NCT06172803 | RESToRE: Restoring Energy With Sub-symptom Threshold Optimized Rehabilitation Exercise for Long COVID | COMPLETED | nan | Columbia University | Restoring Energy with Sub-symptom Threshold Aerobic Rehabilitation Exercise; Light Stretching/Breathing Exercises |
| NCT06017232 | The ParkinSANTÉlé Study: A Multicomponent Telerehabilitation Program to Improve Cardiovascular Health in People With Parkinson's Disease With a Clinical Diagnosis of Dysautono | COMPLETED | nan | Université de Sherbrooke | Hybrid telerehabilitation program |
| NCT04827992 | Evaluation of Medical Cannabis and Prescription Opioid Taper Support for Reduction of Pain and Opioid Dose in Patients With Chronic Non-Cancer Pain | COMPLETED | nan | Massachusetts General Hospital | Medical Marijuana; Prescription Opioid Taper Support (POTS) |
| NCT07182578 | Programming Aquatic Therapy for POTS | COMPLETED | nan | California State University, Dominguez Hills | Aquatic Occupational Therapy |
| NCT06593600 | A Phase 2 Double-Blind Placebo-Controlled Single-Dose Study of Pharmacodynamics, Pharmacokinetics, Safety, and Tolerability of REGN7544, an NPR1 Antagonist Monoclonal Antibody, in | ACTIVE_NOT_RECRUITING | PHASE2 | Regeneron Pharmaceuticals | REGN7544; Placebo |
| NCT06128356 | Pilot Study of Dexmedetomidine Sublingual Film for the Ambulatory Treatment of Hyperadrenergic Autonomic Crisis in Patients With Familial Dysautonomia | ACTIVE_NOT_RECRUITING | PHASE2 | NYU Langone Health | Dexmedetomidine Sublingual |
| NCT04919031 | Inspiratory Muscle Trainer Impact on Post Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) COVID-19 Hypertensive Patients With Long Term Persistent Symptoms | COMPLETED | nan | Cairo University | Inspiratory muscle trainer; diaphragmatic release |
| NCT05279430 | Effects of Inspiratory Muscle Training on Maximal Functional Capacity in Patients With Chronic COVID After Hospital Discharge | COMPLETED | nan | Fundación para la Investigación del Hospital Clínico de Valencia | Inspiratory muscle training |
| NCT04943276 | A Novel Noninvasive Thermoregulatory Device for Postural Tachycardia | COMPLETED | nan | Stanford University | Embr Device |
| NCT06296914 | Developing and Testing a Mobile Health System for Patients with Postural Orthostatic Tachycardia Syndrome (POTS) | COMPLETED | nan | Jami Warren | POTSapp; Waitlist Control |
| NCT05630040 | Vagus Nerve Simulation for Long-COVID-19 | COMPLETED | nan | Icahn School of Medicine at Mount Sinai | Non-invasive vagus nerve stimulation; Sham Intervention |
| NCT07077278 | Effect of Low Sodium Oxybate (LXB) on Autonomic Symptom Burden in Idiopathic Hypersomnia Patients With Postural Tachycardia Syndrome: a Placebo-controlled, Double-blind, Randomized | NOT_YET_RECRUITING | PHASE4 | Stanford University | Low sodium oxybate (LXB); Placebo |
| NCT07359482 | sElective Serotonin reuPtake inhibitoRs In posT-covid: ESPRIT | NOT_YET_RECRUITING | PHASE3 | Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) | Fluvoxamine; Placebo |
| NCT05043051 | Autoimmune Basis for Postural Tachycardia Syndrome | ACTIVE_NOT_RECRUITING | nan | University of Oklahoma | Vagal stimulation; Sham stimulation |
| NCT05363514 | A Pilot Study of Low Dose Naltrexone Use in Patients With Postural Orthostatic Tachycardia Syndrome | NOT_YET_RECRUITING | PHASE4 | University of Calgary | Low Dose Naltrexone; Microcrystalline cellulose |
| NCT06073886 | Personalized Circuit-Based Frontoamygdala Neuromodulation for Persistent Post-Concussive Symptoms | RECRUITING | PHASE2 | University of California, Los Angeles | Active cTBS; Inactive/Sham cTBS; Imaginal exposure |
| NCT05409651 | Phenotyping Mitochondrial and Immune Dysfunction in POTS With Targeted Clinical Intervention. | ACTIVE_NOT_RECRUITING | nan | University of California, San Diego | Time restricted eating |
| NCT07405515 | Pathophysiology of Dysautonomia and Postural Tachycardia Syndrome (POTS) in Post-viral Syndromes and COVID-19 | ACTIVE_NOT_RECRUITING | nan | Brigham and Women's Hospital | Blood Sample Collection |
| ID | Title | Year | Journal | Source | Linked NCTs |
|---|---|---|---|---|---|
| PMID:31215392.0 | Syndrome of Supine Hypertension with Orthostatic Hypotension: Pathophysiology and Clinical Approach. | 2020 | Current cardiology reviews | PubMed | nan |
| PMID:31297663.0 | Dysautonomia in Guillain-Barré Syndrome: Prevalence, Clinical Spectrum, and Outcomes. | 2020 | Neurocritical care | PubMed | nan |
| PMID:31304956.0 | Species interactions modulate the response of saltmarsh plants to flooding. | 2020 | Annals of botany | PubMed | nan |
| PMID:31376088.0 | Systemic sclerosis and urinary symptoms: a complex pathophysiology. | 2020 | Clinical rheumatology | PubMed | nan |
| PMID:31412221.0 | Postural Orthostatic Tachycardia Syndrome: Mechanisms and New Therapies. | 2020 | Annual review of medicine | Europe PMC; PubMed | NCT07019519 |
| PMID:31461628.0 | Brain Responses in CFS and TMD to Autonomic Challenges: An Exploratory fMRI Study. | 2020 | JDR clinical and translational research | PubMed | nan |
| PMID:31524844.0 | The Relationship Between Autonomic Dysfunction of the Gastrointestinal Tract and Emotional Distress in Patients With Systemic Sclerosis. | 2021 | Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases | PubMed | nan |
| PMID:31561388.0 | Intervening Effects of Orthostatic Blood Pressure Change on Subcortical Atrophy and Cognition in De Novo and Drug-Naïve Parkinson's Disease. | 2020 | Journal of Parkinson's disease | PubMed | nan |
| PMID:31583504.0 | Effects of plant growth-promoting bacteria on EDTA-assisted phytostabilization of heavy metals in a contaminated calcareous soil. | 2020 | Environmental geochemistry and health | PubMed | nan |
| PMID:31644656.0 | Root-knot nematode, Meloidogyne javanica, in response to soil fertilization. | 2020 | Brazilian journal of biology = Revista brasleira de biologia | PubMed | nan |
| PMID:31661696.0 | Risk of Multiple System Atrophy and the Use of Anti-Inflammatory Drugs: A Danish Register-Based Case-Control Study. | 2020 | Neuroepidemiology | PubMed | nan |
| PMID:31672071.0 | Screening for Orthostatic Intolerance in Symptomatic Children Presenting for Concussion Care. | 2020 | Clinical pediatrics | PubMed | nan |
| PMID:31704209.0 | Efficacy of entomopathogenic nematodes in insect cadaver formulation against engorged females of Rhipicephalus microplus (Acari: Ixodidae) in semi-field conditions. | 2020 | Ticks and tick-borne diseases | PubMed | nan |
| PMID:31732848.0 | Treatment of Movement Disorder Emergencies in Autoimmune Encephalitis in the Neurosciences ICU. | 2020 | Neurocritical care | PubMed | nan |
| PMID:31733544.0 | Quantification of metal uptake in Spinacia oleracea irrigated with water containing a mixture of CuO and ZnO nanoparticles. | 2020 | Chemosphere | PubMed | nan |
| PMID:31745685.0 | Comparison of Nd:YAG laser (532 nm green) vs diode laser (810 nm) photocoagulation in the treatment of retinopathy of prematurity: an evaluation in terms of complications. | 2020 | Lasers in medical science | PubMed | nan |
| PMID:31747629.0 | Remediation of industrial wastewater using four hydrophyte species: A comparison of individual (pot experiments) and mix plants (constructed wetland). | 2020 | Journal of environmental management | PubMed | nan |
| PMID:31848771.0 | Prevalence and factors related to orthostatic syndromes in recently diagnosed, drug-naïve patients with Parkinson disease. | 2020 | Clinical autonomic research : official journal of the Clinical Autonomic Research Society | PubMed | nan |
| PMID:31858811.0 | Epidemiological and clinical features of amyotrophic lateral sclerosis in a Tunisian cohort. | 2020 | Amyotrophic lateral sclerosis & frontotemporal degeneration | PubMed | nan |
| PMID:31910209.0 | Post mortem evaluation of inflammation, oxidative stress, and PPARγ activation in a nonhuman primate model of cardiac sympathetic neurodegeneration. | 2020 | PloS one | PubMed | nan |
| PMID:31955045.0 | Recycling industrial biosludge for buffel grass production in Qatar: Impact on soil, leachate and plant characteristics. | 2020 | Chemosphere | PubMed | nan |
| PMID:31957505.0 | State-of-the-art pharmacotherapy for autonomic dysfunction in Parkinson's disease. | 2020 | Expert opinion on pharmacotherapy | PubMed | nan |
| PMID:31959114.0 | In-vitro and in-vivo antioxidant assays of chicory plants (Cichorium intybus L.) as influenced by organic and conventional fertilisers. | 2020 | BMC plant biology | PubMed | nan |
| PMID:31979237.0 | Variation in Root and Shoot Growth in Response to Reduced Nitrogen. | 2020 | Plants (Basel, Switzerland) | PubMed | nan |
| PMID:32030573.0 | Dipteryx alata, a tree native to the Brazilian Cerrado, is sensitive to the herbicide nicosulfuron. | 2020 | Ecotoxicology (London, England) | PubMed | nan |
| PMID:32047163.0 | Hydraulic, wash-off and sediment transport experiments in a full-scale urban drainage physical model. | 2020 | Scientific data | PubMed | nan |
| PMID:32056488.0 | Microorganisms in the phylloplane modulate the BVOC emissions of Brassica nigra leaves. | 2020 | Plant signaling & behavior | PubMed | nan |
| PMID:32061988.0 | Microbial inoculant and garbage enzyme reduced cadmium (Cd) uptake in Salvia miltiorrhiza (Bge.) under Cd stress. | 2020 | Ecotoxicology and environmental safety | PubMed | nan |
| PMID:32080891.0 | Tossing and Turning in Bed: Nocturnal Movements in Parkinson's Disease. | 2020 | Movement disorders : official journal of the Movement Disorder Society | PubMed | nan |
| PMID:32104559.0 | Sicca Symptoms in Parkinson's Disease: Association with Other Nonmotor Symptoms and Health-Related Quality of Life. | 2020 | Parkinson's disease | PubMed | nan |
| PMID:32120154.0 | Direct and residual impacts of zeolite on the remediation of harmful elements in multiple contaminated soils using cabbage in rotation with corn. | 2020 | Chemosphere | PubMed | nan |
| PMID:32140630.0 | Cerebral blood flow is reduced in ME/CFS during head-up tilt testing even in the absence of hypotension or tachycardia: A quantitative, controlled study using Doppler echography. | 2020 | Clinical neurophysiology practice | Europe PMC; PubMed | nan |
| PMID:32145864.0 | Canadian Cardiovascular Society Position Statement on Postural Orthostatic Tachycardia Syndrome (POTS) and Related Disorders of Chronic Orthostatic Intolerance. | 2020 | The Canadian journal of cardiology | Europe PMC; PubMed | NCT05404672; NCT05855356 |
| PMID:32152864.0 | Commercial glyphosate-based herbicides effects on springtails (Collembola) differ from those of their respective active ingredients and vary with soil organic matter content. | 2020 | Environmental science and pollution research international | PubMed | nan |
| PMID:32171889.0 | Complex syndromes of chronic pain, fatigue and cognitive impairment linked to autoimmune dysautonomia and small fiber neuropathy. | 2020 | Clinical immunology (Orlando, Fla.) | Europe PMC; PubMed | nan |
| PMID:32184791.0 | Interactional Effects of Climate Change Factors on the Water Status, Photosynthetic Rate, and Metabolic Regulation in Peach. | 2020 | Frontiers in plant science | PubMed | nan |
| PMID:32186729.0 | Are arbuscular-mycorrhizal Alnus incana seedlings more resistant to drought than ectomycorrhizal and nonmycorrhizal ones? | 2020 | Tree physiology | PubMed | nan |
| PMID:32188977.0 | Glyphosate-based herbicide affects the composition of microbes associated with Colorado potato beetle (Leptinotarsa decemlineata). | 2020 | FEMS microbiology letters | PubMed | nan |
| PMID:32205924.0 | Foliar applied fullerol differentially improves salt tolerance in wheat through ion compartmentalization, osmotic adjustments and regulation of enzymatic antioxidants. | 2020 | Physiology and molecular biology of plants : an international journal of functional plant biology | PubMed | nan |
| PMID:32222506.0 | Effects of mineral-solubilizing microbial strains on the mechanical responses of roots and root-reinforced soil in external-soil spray seeding substrate. | 2020 | The Science of the total environment | PubMed | nan |
| PMID:32228515.0 | Effect of arsenic stress on 5-methylcytosine, photosynthetic parameters and nutrient content in arsenic hyperaccumulator Pteris cretica (L.) var. Albo-lineata. | 2020 | BMC plant biology | PubMed | nan |
| PMID:32228576.0 | Increased soil moisture aggravated the competitive effects of the invasive tree Rhus typhina on the native tree Cotinus coggygria. | 2020 | BMC ecology | PubMed | nan |
| PMID:32252345.0 | The Aquaporin-3-Inhibiting Potential of Polyoxotungstates. | 2020 | International journal of molecular sciences | PubMed | nan |
| PMID:32253356.0 | Dysautonomia in 53 cats and dogs: retrospective review of clinical data and outcome. | 2020 | The Veterinary record | PubMed | nan |
| PMID:32276352.0 | Role of Ascorbic acid, Glutathione and Proline Applied as Singly or in Sequence Combination in Improving Chickpea Plant through Physiological Change and Antioxidant Defense under Different Levels of Irrigation Intervals. | 2020 | Molecules (Basel, Switzerland) | PubMed | nan |
| PMID:32293047.0 | Metarhizium anisopliae sensu lato (s.l.) oil-in-water emulsions drastically reduced Rhipicephalus microplus larvae outbreak population on artificially infested grass. | 2020 | Medical and veterinary entomology | PubMed | nan |
| PMID:32314650.0 | Pediatric-Onset Postural Orthostatic Tachycardia Syndrome in a Single Tertiary Care Center. | 2020 | Journal of child neurology | Europe PMC; PubMed | nan |
| PMID:32325603.0 | Does Brachiaria humidicola and dicyandiamide reduce nitrous oxide and ammonia emissions from cattle urine patches in the subtropics? | 2020 | The Science of the total environment | PubMed | nan |
| PMID:32330855.0 | Biofortification of chromium in fenugreek seeds. | 2020 | Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elem | PubMed | nan |
| PMID:32339766.0 | Degenerate-disc infection study with contaminant control (DISC): a multicenter prospective case-control trial. | 2020 | The spine journal : official journal of the North American Spine Society | PubMed | nan |
| NCT ID | Title | Status | Phase | Sponsor | Intervention |
|---|---|---|---|---|---|
| NCT04871815 | Preliminary Examination of the Effects of Sodium Pyruvate Nasal Spray (N115) on Symptoms Associated With COVID19 Long Haulers. | COMPLETED | PHASE2; PHASE3 | Cellular Sciences, inc. | sodium pyruvate nasal spray |
| NCT05104749 | Homeopathic Treatment of Post-acute COVID-19 Syndrome- A Pilot Randomized Controlled Trial | COMPLETED | PHASE3 | Southwest College of Naturopathic Medicine | Homeopathic Medication; Placebo |
| NCT04510194 | COVID-OUT: Early Outpatient Treatment for SARS-CoV-2 Infection (COVID-19) | COMPLETED | PHASE3 | University of Minnesota | Metformin; Placebo; Fluvoxamine; Ivermectin |
| NCT05212610 | Assessing Safety of COVID-19 mRNA Vaccine Administration in the Setting of a Previous Adverse Reaction | COMPLETED | PHASE4 | University of Michigan | Pfizer-BioNTech mRNA COVID-19 vaccine; Moderna mRNA COVID-19 vaccine |
| NCT05999435 | A DOUBLE-BLIND, RANDOMIZED, PLACEBO-CONTROLLED, ADAPTIVE PHASE 2/3 STUDY OF THE EFFICACY OF LAU-7b IN THE TREATMENT OF ADULTS WITH LONG COVID AND MODERATE TO SEVERE SYMPTOMS | COMPLETED | PHASE2; PHASE3 | Laurent Pharmaceuticals Inc. | LAU-7b for 3 cycles; LAU-7b for 1 cycle, then placebo; Placebo for 3 cycles |
| NCT05074888 | A Multicenter, Double-blind, Placebo-controlled, Parallel-group, Randomized Clinical Trial of Efficacy and Safety of Prospekta in the Treatment of Patients With Post-COVID-19 Asthe | COMPLETED | PHASE3 | Materia Medica Holding | Prospekta; Placebo |
| NCT05047952 | Randomized, Double-Blinded, Placebo-Controlled Study Evaluating Vortioxetine for Cognitive Deficits in Persons With Post-COVID-19 Condition | COMPLETED | PHASE2 | Brain and Cognition Discovery Foundation | Vortioxetine; Placebo |
| NCT05970731 | Directed Topical Drug Delivery for Treatment for PASC Hyposmia | COMPLETED | PHASE2 | Duke University | Beclomethasone; Placebo; Microsponge |
| NCT05633407 | A Phase 2 Randomized, Double-blinded, Placebo-controlled Study to Evaluate the Efficacy and Safety of Efgartigimod IV in Adult Patients With Post-COVID-19 Postural Orthostatic Tach | COMPLETED | PHASE2 | argenx | Efgartigimod; Placebo |
| NCT04920916 | Safety and Efficacy of the Treatment of Hospitalized Patients With COVID 19 Infection With an Inhibitor of IL-4 and IL-13 Signaling: A Phase IIa Trial | COMPLETED | PHASE2 | University of Virginia | Dupilumab; Placebo |
| NCT05618587 | Effect of Low-dose Lithium Therapy on Long COVID Symptoms: a Randomized Controlled Trial. | COMPLETED | PHASE2 | State University of New York at Buffalo | Lithium; Placebo |
| NCT05592418 | A Randomized, Double Blind, Placebo Controlled Study to Evaluate the Efficacy and Safety of Ampligen® in Patients With Post-COVID Conditions | COMPLETED | PHASE2 | AIM ImmunoTech Inc. | Rintatolimod; Placebo / Normal Saline |
| NCT05121740 | Extension Study in a Cohort of Adult Patients With SARS-CoV-2 Infection Requiring Hospital Admission and Received Treatment With Plitidepsin in the APLICOV-PC Study | COMPLETED | PHASE1; PHASE2 | PharmaMar | Plitidepsin 1.5 mg / day; Plitidepsin 2.0 mg / day; Plitidepsin 2.5 mg / day |
| NCT05576662 | Selective Trial Of Paxlovid for PASC (STOP-PASC): Randomized Double-Blind Placebo-Controlled Pilot Trial of Paxlovid for the Treatment of PASC | COMPLETED | PHASE2 | Stanford University | Nirmatrelvir; Placebo; Ritonavir |
| NCT05965726 | RECOVER-VITAL: A Platform Protocol for Evaluation of Interventions for Viral Persistence, Viral Reactivation, and Immune Dysregulation in Post-Acute Sequelae of SARS-CoV-2 Infectio | COMPLETED | PHASE2 | Kanecia Obie Zimmerman | Paxlovid; Ritonavir; Nirmatrelvir-matching placebo |
| NCT06253806 | Stellate Ganglion Block for the Treatment of COVID-19-Induced Parosmia: Double-Blinded, Placebo-Controlled Randomized Clinical Trial | COMPLETED | PHASE2 | Washington University School of Medicine | Stellate Ganglion Block; Placebo Sham Injection |
| NCT05126563 | A Randomized, Double-blinded, Single-center, Phase 2 Efficacy, and Safety Study of Allogeneic HB-adMSCs for the Treatment of Patients With Chronic Post-COVID-19 Syndrome. | COMPLETED | PHASE2 | Hope Biosciences Research Foundation | HB-adMSCs (allogeneic); Placebo |
| NCT05595369 | RECOVER-VITAL: A Platform Protocol for Evaluation of Interventions for Viral Persistence, Viral Reactivation, and Immune Dysregulation in Post-Acute Sequelae of SARS-CoV-2 Infectio | COMPLETED | PHASE2 | Kanecia Obie Zimmerman | Experimental: Paxlovid 25 day dosing; Experimental: Paxlovid 15 day dosing; Placebo Comparator: Control |
| NCT05445921 | Stellate Ganglion Block for the Treatment of COVID-19-Induced Olfactory Dysfunction: A Prospective Pilot Study | COMPLETED | PHASE1; PHASE2 | Washington University School of Medicine | Stellate Ganglion Block |
| NCT05472090 | A Phase 2, 14-week Double-Blind, Randomized, Multicenter, Placebo-Controlled Study to Evaluate the Efficacy and Safety of TNX-102 SL Taken Daily at Bedtime in Patients With Multisi | COMPLETED | PHASE2 | Tonix Pharmaceuticals, Inc. | TNX-102 SL; Placebo SL Tablet |
| NCT04828135 | Characterizing the Long-Term Cardiopulmonary Effects of COVID-19 With Hyperpolarized Xenon and Cardiac MRI | COMPLETED | PHASE2 | Bastiaan Driehuys | Hyperpolarized 129Xenon gas |
| NCT06136871 | Cognitive Strategy Training in Post-COVID-19 Syndrome: A Feasibility Trial | COMPLETED | nan | University of Missouri-Columbia | CO-OP Procedures; Inactive Control Group |
| NCT05970861 | Effect of Natural Food on Gut Microbiome and Phospholipid Spectrum of Immune Cells in COVID-19 Patients | COMPLETED | nan | Asfendiyarov Kazakh National Medical University | Freeze-dried Mare Milk (Saumal) |
| NCT06476496 | Pain Relief With Integrative Medicine (PRIMe)?: Feasibility of Acupuncture for Long COVID | COMPLETED | nan | University of Washington | Acupuncture |
| NCT05965752 | RECOVER-NEURO: A Platform Protocol for Evaluation of Interventions for Cognitive Dysfunction in Post-Acute Sequelae of SARS-CoV-2 Infection (PASC) | COMPLETED | nan | Duke University | BrainHQ/Active Comparator Activity; BrainHQ; PASC CoRE; tDCS-active; tDCS-sham |
| NCT05877508 | An Exploratory, Randomized, Double-Blind Placebo-Controlled Study to Assess the Safety of an Anti-SARS-CoV-2 Monoclonal Antibody and Response to Treatment in Individuals With Long | ACTIVE_NOT_RECRUITING | PHASE2 | Michael Peluso, MD | AER002; Placebo |
| NCT04880161 | A Randomized, Double-Blinded, Placebo-Controlled Phase I Study to Evaluate the Safety and Efficacy of Ampion in Patients With Prolonged Respiratory Symptoms Due to COVID-19 (Long C | COMPLETED | PHASE1 | Ampio Pharmaceuticals. Inc. | Ampion; Placebo |
| NCT06161688 | Placebo-Controlled, Randomized Trial of Ensitrelvir (S-217622) for Viral Persistence and Inflammation in People Experiencing Long COVID (PREVAIL-LC) | ACTIVE_NOT_RECRUITING | PHASE2 | Timothy Henrich | Ensitrelvir; Placebo |
| NCT05608629 | Vagus Nerve Stimulation as Treatment for Long Covid | COMPLETED | nan | Icahn School of Medicine at Mount Sinai | Transcutaneous Non-Invasive Vagus Nerve Stimulation |
| NCT06214455 | The Effect of a No-added Sugar Diet, Time-restricted Eating and Periodic Water Fasting on Long COVID Symptoms | COMPLETED | nan | Pacific Northwest University of Health Sciences | Low sugar diet and 10-12 hour eating window; Low sugar diet, 8 hour eating window and fasting |
| NCT05445427 | Outcomes of Treatment With Vagal Nerve Stimulation in Post-COVID Syndrome: A Pilot Study | COMPLETED | nan | Mayo Clinic | vagal nerve stimulator |
| NCT05199233 | The Benefit of Mindfulness-Based Intervention Using A Wearable Wellness Brain Sensing Device (Muse-S™) in the Treatment of Post-Covid Symptoms | COMPLETED | nan | Mayo Clinic | Muse S™ Headband system |
| NCT05453201 | Developing an Integrative, Recovery-Based, Post-Acute COVID-19 Syndrome (PACS) Psychotherapeutic Intervention | COMPLETED | nan | VA Office of Research and Development | Long COVID Coping and Recovery (LCCR) Intervention |
| NCT05200858 | Transcutaneous Electrical Nerve Stimulation For Lower Extremity In Patients With Neurogenic Pain - A Proof Of Concept Randomized Clinical Trial | COMPLETED | nan | Baylor College of Medicine | TENS - high-dose; TENS - low-dose |
| NCT05205460 | Effectiveness of a 12-week Telerehabilitation Training in People With Long COVID: A Randomized Controlled Trial | COMPLETED | nan | Tri-Service General Hospital | Home-based telerehabilitation; Education and self-exercise |
| NCT06524739 | Double-blind, Randomized, Placebo-controlled Phase 3 Study Evaluating Efficacy and Safety of IgPro20 (Subcutaneous Immunoglobulin, HIZENTRA®) in Post-COVID-19 Postural Orthostatic | TERMINATED | PHASE3 | CSL Behring | IgPro20; Placebo |
| NCT05946551 | Feasibility Assessment of a Decentralized Platform Adaptive Double-Blind, Randomized Controlled Trial Investigating Repurposed Drugs in the Treatment of Post-Acute Sequelae of Coro | TERMINATED | PHASE3 | Emory University | Cetirizine; Famotidine; Cetirizine Placebo; Famotidine Placebo |
| NCT05092516 | Home-based Transcranial Direct Current Stimulation (tDCS) for Treatment of Cognitive Post-acute Sequelae of COVID-19 (PASC) | ACTIVE_NOT_RECRUITING | nan | Massachusetts General Hospital | Active tDCS; Sham tDCS |
| NCT05597722 | Randomized Study to Evaluate Strategies to Address Cognitive Fog in Long-COVID-19 Patients | TERMINATED | PHASE4 | Eva Szigethy | Digital cognitive behavioral intervention-RxWell; Amphetamine-Dextroamphetamine |
| NCT05918978 | Open-Label Extension Study to Evaluate the Long-term Safety and Efficacy of Efgartigimod in Adult Patients With Post-COVID-19 Postural Orthostatic Tachycardia Syndrome (PC-POTS) Wh | TERMINATED | PHASE2 | argenx | Efgartigimod |
| NCT05204550 | A Randomised, Placebo-controlled Trial to Investigate the Efficacy of Intranasal Heparin Treatment to Reduce Transmission of SARS-CoV-2 Infection and COVID 19 Disease Among Househo | COMPLETED | PHASE2; PHASE3 | Murdoch Childrens Research Institute | unfractionated heparin; 0.9%sodium chloride |
| NCT05513560 | REcovering From COVID-19 Lingering Symptoms Adaptive Integrative Medicine (RECLAIM) | COMPLETED | PHASE2; PHASE3 | University Health Network, Toronto | Ibudilast; Pentoxifylline; Placebo |
| NCT05096884 | Post-Acute Sequelae of Coronavirus-19 (COVID-19) With DysPnEA on ExertIon And Associated TaChycardia TrEatment Study | TERMINATED | EARLY_PHASE1 | Hackensack Meridian Health | Metoprolol Succinate |
| NCT04988282 | Systemic Corticosteroids in Treatment of Post-COVID-19 Interstitial Lung Disease | COMPLETED | PHASE4 | Turkish Thoracic Society | Methylprednisolone Tablet |
| NCT05638633 | Prednisolone and Vitamin B1, B6, and B12 in Patients With Post-COVID-19-Syndrome (PC19S) - a Randomized Controlled Trial in Primary Care | COMPLETED | PHASE3 | Wuerzburg University Hospital | Prednisolone 20 mg/ 5 mg; Vitamin B compound (100mg B1, 50 mg B6, 500 µg B12); Placebo for Vitamin B compound; Placebo for Prednisolon |
| NCT04591210 | Evaluation of the Potential Benefit of Renin-angiotensin System Inhibitors (RASi, ACEi/ARB) in High-risk Patients With COVID-19. The COVID-RASi Trial | COMPLETED | PHASE3 | Ottawa Heart Institute Research Corporation | Angiotensin converting enzyme inhibitor; Angiotensin II Receptor Blockers |
| NCT05795816 | The Effectiveness of Testofen on Energy, Fatigue, Mental Acuity, and Other Quality of Life Symptoms Post COVID-19 Infection | COMPLETED | PHASE3 | RDC Clinical Pty Ltd | Testofen; Microcrystalline cellulose |
| NCT05939622 | Prospective Randomized Double Blind Placebo Controlled Study of Efficacy of the Therapy With BRAINMAX® Using Functional Magnetic Resonance Imaging (fMRI) for the Treatment of Patie | COMPLETED | PHASE4 | Promomed, LLC | Structural and functional MRI; Ethyl methyl hydroxypyridine succinate + Meldonium; Placebo |
| NCT05524532 | Effect of Immulina Supplements on Inflammatory Biomarkers Correlated With Clinical Symptoms in Patients With Long COVID (PASC) | COMPLETED | PHASE3 | University of Mississippi Medical Center | Immulina TM; Placebo |
| NCT04795557 | Effect of ADAPT232 Supplementation on Recovery of Patients in Rehabilitation Period in Long COVID-19: a Randomized, Double-blind, Placebo-controlled Trial | COMPLETED | PHASE2; PHASE3 | Swedish Herbal Institute AB | ADAPT-232 oral solution; Placebo oral solution |
| ID | Title | Year | Journal | Source | Linked NCTs |
|---|---|---|---|---|---|
| PMID:32302966.0 | Health Communication Through News Media During the Early Stage of the COVID-19 Outbreak in China: Digital Topic Modeling Approach. | 2020 | Journal of medical Internet research | PubMed | nan |
| PMID:32310190.0 | Coronavirus drugs: Using plasma from recovered patients as a treatment for COVID-19. | 2020 | The International journal of risk & safety in medicine | PubMed | nan |
| PMID:32339235.0 | A Quantitative Framework for Modeling COVID-19 Risk During Adjuvant Therapy Using Published Randomized Trials of Glioblastoma in the Elderly. | 2020 | Neuro-oncology | PubMed | nan |
| PMID:32365022.0 | Towards Contactless Patient Positioning. | 2020 | IEEE transactions on medical imaging | PubMed | nan |
| PMID:32369624.0 | Coronavirus Disease 2019 Hangover: A Rising Tide of Alcohol Use Disorder and Alcohol-Associated Liver Disease. | 2020 | Hepatology (Baltimore, Md.) | PubMed | nan |
| PMID:32373061.0 | Triage of Acute Ischemic Stroke in Confirmed COVID-19: Large Vessel Occlusion Associated With Coronavirus Infection. | 2020 | Frontiers in neurology | PubMed | nan |
| PMID:32376593.0 | [Liquid chromatography tandem mass spectrometry for therapeutic drug monitoring of voriconazole in heat-inactivated blood samples: its application during COVID-19 pandemic]. | 2020 | Nan fang yi ke da xue xue bao = Journal of Southern Medical University | PubMed | nan |
| PMID:32377176.0 | Management of Pancreatic Cancer During COVID-19 Pandemic: To Treat or Not to Treat? | 2020 | JOP : Journal of the pancreas | PubMed | nan |
| PMID:32383576.0 | Up to 2.2 million people experiencing disability suffer collateral damage each day of COVID-19 lockdown in Europe. | 2020 | European journal of physical and rehabilitation medicine | PubMed | nan |
| PMID:32387014.0 | [Repurposing of chlorpromazine in COVID-19 treatment: the reCoVery study]. | 2020 | L'Encephale | PubMed | nan |
| PMID:32387564.0 | Emergence of genomic diversity and recurrent mutations in SARS-CoV-2. | 2020 | Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in i | PubMed | nan |
| PMID:32387778.0 | First confirmed detection of SARS-CoV-2 in untreated wastewater in Australia: A proof of concept for the wastewater surveillance of COVID-19 in the community. | 2020 | The Science of the total environment | PubMed | nan |
| PMID:32419749.0 | Consensus Statement - Suggested Recommendations for Acute Stroke Management during the COVID-19 Pandemic: Expert Group on Behalf of the Indian Stroke Association. | 2020 | Annals of Indian Academy of Neurology | PubMed | nan |
| PMID:32423449.0 | Rationale for the clinical use of adipose-derived mesenchymal stem cells for COVID-19 patients. | 2020 | Journal of translational medicine | PubMed | nan |
| PMID:32425222.0 | Repurposing chlorpromazine to treat COVID-19: The reCoVery study. | 2020 | L'Encephale | PubMed | nan |
| PMID:32425428.0 | Internet of Medical Things (IoMT) for orthopaedic in COVID-19 pandemic: Roles, challenges, and applications. | 2020 | Journal of clinical orthopaedics and trauma | PubMed | nan |
| PMID:32426387.0 | Artificial intelligence approach fighting COVID-19 with repurposing drugs. | 2020 | Biomedical journal | PubMed | nan |
| PMID:32428242.0 | COVID-19 and myeloma: what are the implications for now and in the future? | 2020 | British journal of haematology | PubMed | nan |
| PMID:32431134.0 | How the COVID-19 infection tsunami revolutionized the work of respiratory physiotherapists: an experience from Northern Italy. | 2020 | Monaldi archives for chest disease = Archivio Monaldi per le malattie del torace | PubMed | nan |
| PMID:32431755.0 | The novel immunomodulatory biologic LMWF5A for pharmacological attenuation of the "cytokine storm" in COVID-19 patients: a hypothesis. | 2020 | Patient safety in surgery | PubMed | nan |
| PMID:32436617.0 | Immunosuppressive agents for dermatological indications in the ongoing COVID-19 pandemic: Rationalizing use and clinical applicability. | 2020 | Dermatologic therapy | PubMed | nan |
| PMID:32444743.0 | Why re-invent the wheel if you've run out of road? | 2020 | British dental journal | PubMed | nan |
| PMID:32445330.0 | Time, distance, shielding and ALARA; drawing similarities between measures for radiation protection and Coronavirus disease pandemic response. | 2020 | Indian journal of cancer | PubMed | nan |
| PMID:32473179.0 | Evidence for decontamination of single-use filtering facepiece respirators. | 2020 | The Journal of hospital infection | PubMed | nan |
| PMID:32475821.0 | The Stanford Hall consensus statement for post-COVID-19 rehabilitation. | 2020 | British journal of sports medicine | PubMed | NCT05531019 |
| PMID:32493466.0 | Real-time monitoring the transmission potential of COVID-19 in Singapore, March 2020. | 2020 | BMC medicine | PubMed | nan |
| PMID:32503806.0 | The World of Clinical Trial Development Post COVID-19: Lessons Learned from a Global Pandemic. | 2020 | Clinical cancer research : an official journal of the American Association for Cancer Research | PubMed | nan |
| PMID:32503825.0 | Breast Cancer and COVID-19: The Effect of Fear on Patients' Decision-making Process. | 2020 | In vivo (Athens, Greece) | PubMed | nan |
| PMID:32505489.0 | Role of Rehabilitation Department for Adult Individuals With COVID-19: The Experience of the San Raffaele Hospital of Milan. | 2020 | Archives of physical medicine and rehabilitation | PubMed | nan |
| PMID:32510142.0 | α-glucosidase inhibitors as host-directed antiviral agents with potential for the treatment of COVID-19. | 2020 | Biochemical Society transactions | PubMed | nan |
| PMID:32517822.0 | Factors associated with the duration of hospitalisation among COVID-19 patients in Vietnam: A survival analysis. | 2020 | Epidemiology and infection | PubMed | nan |
| PMID:32521463.0 | Managing common endocrine disorders amid COVID-19 pandemic. | 2020 | Diabetes & metabolic syndrome | PubMed | nan |
| PMID:32532661.0 | Management and outcomes of post-acute COVID-19 patients in Northern Italy. | 2020 | European journal of internal medicine | PubMed | nan |
| PMID:32557183.0 | Assessment of paediatric dental guidelines and caries management alternatives in the post COVID-19 period. A critical review and clinical recommendations. | 2020 | European archives of paediatric dentistry : official journal of the European Academy of Paediatric D | PubMed | nan |
| PMID:32563283.0 | Special considerations in the management of adult patients with acute leukaemias and myeloid neoplasms in the COVID-19 era: recommendations from a panel of international experts. | 2020 | The Lancet. Haematology | PubMed | nan |
| PMID:32566960.0 | Transitioning to a New Normal in the Post-COVID Era. | 2020 | Current oncology reports | PubMed | nan |
| PMID:32570016.0 | Application of cognitive Internet of Medical Things for COVID-19 pandemic. | 2020 | Diabetes & metabolic syndrome | PubMed | nan |
| PMID:32586336.0 | A prospect on the use of antiviral drugs to control local outbreaks of COVID-19. | 2020 | BMC medicine | PubMed | nan |
| PMID:32599178.0 | COVID-19 cardiac injury: Implications for long-term surveillance and outcomes in survivors. | 2020 | Heart rhythm | PubMed | nan |
| PMID:32607508.0 | A facile Q-RT-PCR assay for monitoring SARS-CoV-2 growth in cell culture. | 2020 | bioRxiv : the preprint server for biology | PubMed | nan |
| PMID:32629273.0 | Snowballing transmission of COVID-19 (SARS-CoV-2) through wastewater: Any sustainable preventive measures to curtail the scourge in low-income countries? | 2020 | The Science of the total environment | PubMed | nan |
| PMID:32655581.0 | Flattening the COVID-19 Curve With Natural Killer Cell Based Immunotherapies. | 2020 | Frontiers in immunology | PubMed | nan |
| PMID:32658716.0 | Ecotoxic response of nematodes to ivermectin, a potential anti-COVID-19 drug treatment. | 2020 | Marine pollution bulletin | PubMed | nan |
| PMID:32658857.0 | COVID-19 and Telepsychiatry: Development of Evidence-Based Guidance for Clinicians. | 2020 | JMIR mental health | PubMed | nan |
| PMID:32664309.0 | Effect of the COVID-19 Pandemic on Treatment Delays in Patients with ST-Segment Elevation Myocardial Infarction. | 2020 | Journal of clinical medicine | PubMed | nan |
| PMID:32666857.0 | Social Support is Key to Retention in Care during Covid-19 Pandemic among Older People with HIV and Substance Use Disorders in Ukraine. | 2020 | Substance use & misuse | PubMed | nan |
| PMID:32669623.0 | Survivorship after COVID-19 ICU stay. | 2020 | Nature reviews. Disease primers | PubMed | nan |
| PMID:32672029.0 | Rehabilitation needs of the first cohort of post-acute COVID-19 patients in Hubei, China. | 2020 | European journal of physical and rehabilitation medicine | PubMed | nan |
| PMID:32673837.0 | Indian Publications on SARS-CoV-2: A bibliometric study of WHO COVID-19 database. | 2020 | Diabetes & metabolic syndrome | PubMed | nan |
| PMID:32674827.0 | How a Barcelona Post-Acute Facility became a Referral Center for Comprehensive Management of Subacute Patients With COVID-19. | 2020 | Journal of the American Medical Directors Association | PubMed | nan |
| NCT ID | Title | Status | Phase | Sponsor | Intervention |
|---|---|---|---|---|---|
| NCT03356821 | Adult Mesenchymal Stromal Cells to Regenerate the Neonatal Brain: the PASSIoN Trial (Perinatal Arterial Stroke Treated With Stromal Cells IntraNasally) | COMPLETED | PHASE1; PHASE2 | UMC Utrecht | Mesenchymal Stem Cells |
| NCT04938687 | Pilot, Effect of Respiratory-Gated Auricular Vagal Afferent Nerve Stimulation (RAVANS) on Post-Treatment Lyme Disease Syndrome | COMPLETED | nan | Spaulding Rehabilitation Hospital | respiratory-gated auricular vagal afferent nerve stimulation (RAVANS); Sham RAVANS |
| NCT04705831 | A Randomized, Double Blind, Placebo Controlled, Cross-Over, Proof-of-Concept Study to Evaluate the Benefit of RUCONEST (C1 Esterase Inhibitor [Recombinant]) in Improving Neurologic | COMPLETED | PHASE2 | IMMUNOe Research Centers | Ruconest |
| NCT04961190 | A Comparison of Prolonged Exposure Therapy, Pharmacotherapy, and Their Combination for PTSD: What Works Best, and for Whom | ACTIVE_NOT_RECRUITING | PHASE4 | University of Pennsylvania | Prolonged Exposure Therapy; Pharmacotherapy with paroxetine or venlafaxine XR |
| NCT05760092 | The Use of Photobiomodulation in the Treatment of Oral Complaints of Long COVID-19. A Randomized Controlled Trial. | COMPLETED | PHASE2 | University of Nove de Julho | Institutional standard treatment for xerostomia and Long Covid; Photobiomodulation Therapy; Placebo Photobiomodulation Therapy |
| NCT05430152 | A Double Blind Randomized Trial of Low-dose Naltrexone for Post-COVID Fatigue Syndrome | COMPLETED | PHASE2 | Luis Nacul | Low-Dose Naltrexone; Placebo |
| NCT06694740 | Effect of Interferon Gamma as a Treatment for Post-aggressive Immunosuppression in Intensive Care Units, a Randomized Bayesian Double-blind Controlled Trial Versus Placebo | RECRUITING | PHASE2; PHASE3 | Assistance Publique - Hôpitaux de Paris | Interferon Gamma 1-b; Placebo |
| NCT07280572 | RECLAIM: an Adaptive Platform Trial for the Evaluation of Treatments for Post-Acute Sequelae of SARS-CoV-2 Infection (PASC) | ENROLLING_BY_INVITATION | PHASE3 | Janneke van de Wijgert | Metformin; colchicine |
| NCT04396652 | Comparison of Adductor Canal Block, Peri-articular Injection or Infiltration Between Popliteal Artery and Posterior Knee Capsule (IPACK) With Adductor Canal Block in Total Knee Art | COMPLETED | nan | Tanta University | Adductor canal block (ACB) group; Peri-articular injection group; Adductor canal block and IPACK block group |
| NCT05664711 | Effect of Stellate Ganglion Block on ME/CFS Symptoms and Metabolites | COMPLETED | PHASE1 | Neuroversion, Inc. | Bupivacaine Injection |
| NCT04741841 | Effect of Probiotic Food Supplement "GutMagnific™" in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS), Also Known as Post-viral Fatigue Syndrome, and Comorbid | COMPLETED | nan | ImmuneBiotech Medical Sweden AB | GutMagnific™ H.; GutMagnific™ L.; Placebo |
| NCT06631287 | Randomized Double-Blind Placebo-Controlled Trial EValuating Baricitinib on PERSistent NEurologic and Cardiopulmonary Symptoms of Long COVID (REVERSE-LC) | RECRUITING | PHASE3 | Wes Ely | Baricitinib; Placebo |
| NCT05305105 | Effects of Psilocybin in Post-Treatment Lyme Disease | COMPLETED | PHASE1 | Johns Hopkins University | Psilocybin |
| NCT05571098 | The Effects of Nurse Navigation Program on Symptom Management and Psychosocial Adjustment Applied to Patients With Colorectal Cancer | COMPLETED | nan | Saglik Bilimleri Universitesi | individualized colorectal cancer education; psycho-oncological counseling; telephone support hotline service |
| NCT06511050 | Investigating the Effects of Lumbrokinase in Adults With Long Covid, Post-treatment Lyme Disease Syndrome, and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome | RECRUITING | PHASE1; PHASE2 | Icahn School of Medicine at Mount Sinai | Lumbrokinase |
| NCT05219929 | T4 - Tetracycline Treatment Tolerability Trial A Pilot Study Examining the Feasibility and Tolerability of Tetracycline Therapy in Post-Treatment Lyme Disease (PTLD) | ENROLLING_BY_INVITATION | PHASE2 | Johns Hopkins University | Tetracycline 500 Mg; Placebo |
| NCT06978582 | Effectiveness and Safety of a Tele-rehabilitation Program Based on Mindful and Conscious Movement-based Exercise vs Conventional Low-intensity Exercise on Fatigue and Related Varia | ACTIVE_NOT_RECRUITING | nan | University of Seville | Mindful and conscious movement-based exercise; Conventional exercise |
| NCT06655844 | Extended Home-use Trial of a Novel Device to Reduce Chronic Pain | RECRUITING | nan | Icahn School of Medicine at Mount Sinai | Sana Pain Reliever; Sham SPR |
| NCT05682196 | Open-label, Randomized Controlled Trial to Assess Efficacy and Safety of Rituximab in Patients With Acute Rheumatic Fever in Africa | SUSPENDED | PHASE2 | African Academy of Methodology and Statistics | Rituximab added to standard of care treatment; standard of care treatment alone |
| NCT05688241 | Epstein-Barr Virus (EBV) -Specific T Memory Stem Cell (Tscm) Therapy to Treat EBV- Driven Lymphomas/ Diseases | NOT_YET_RECRUITING | PHASE1; PHASE2 | University Hospital, Basel, Switzerland | Donor-derived ex-vivo expanded EBV Tscm CTL |
| NCT06611111 | Phase 1, Randomized, Double-Blind, Placebo-Controlled Trial of Pulse Dosed Ceftriaxone for Post-Treatment Lyme Disease | RECRUITING | EARLY_PHASE1 | State University of New York - Upstate Medical University | Ceftriaxone (Rocephin®); Dextrose 5% (D5W) |
| NCT05776251 | Transcutaneous Auricular Vagus Nerve Stimulation (taVNS) for Persistent Symptoms From Lyme Disease: a Feasibility, Tolerability, and Safety Study | RECRUITING | nan | Columbia University | taVNS |
| NCT06915324 | Transcranial Direct Current Stimulation (tDCS) of Brain Fog in Patients With Post Treatment Lyme Disease | RECRUITING | nan | Columbia University | Transcranial Direct Current Stimulation (tDCS); Cognitive training |
| NCT05371522 | Neuro-inflammation and Post-infectious Fatigue in Individuals With and Without COVID-19 | UNKNOWN | PHASE2; PHASE3 | Amsterdam UMC, location VUmc | [18F]DPA-714 positron emission tomography (PET) scan |
| NCT06666153 | A Clinical Study Evaluating the Safety, Tolerability, and Initial Efficacy of Therapeutic Immunological Agent for EBV Lymphoproliferative Diseases | NOT_YET_RECRUITING | PHASE1 | West China Hospital | EBV immunological agent |
| NCT07523113 | Brain Training for Chronic, Post-viral, Brain Fog: Study A | NOT_YET_RECRUITING | nan | University of Alabama at Birmingham | Processing Speed Training; In-session Instrumental Activities of Daily Living Training; Transfer Package; Follow Up Phone Calls; Trans-auricular Vagus Nerve Sti |
| NCT04507477 | Ex-vivo Delivery of Rituximab to Prevent Post-transplant Lymphoproliferative Disease in Epstein-Barr Virus Mismatch Lung Transplant Recipients: A Pilot Trial | UNKNOWN | PHASE1; PHASE2 | University Health Network, Toronto | Rituximab |
| NCT06992414 | Exploring Creatine Supplementation for Improved Exercise Capacity and Reduced Fatigue in Long COVID-19: A Randomized Controlled Trial | NOT_YET_RECRUITING | nan | University of Calgary | Creatine monohydrate |
| NCT06785402 | Phase 1/2, Randomized, Double-Blind, Placebo-Controlled Trial of Pulse Dosed Ceftriaxone for Post-Treatment Lyme Disease | WITHDRAWN | PHASE1; PHASE2 | Hackensack Meridian Health | Ceftriaxone treatment; Placebo |
| NCT07454395 | Investigating the Effect of Swimming on Autonomic and Symptomatic Responses in Individuals With Myalgic Encephalomyelitis/Chronic Fatigue Syndrome | SUSPENDED | nan | Simon Fraser University | Swimming; Cycling |
| NCT05753228 | In Vivo Investigation on Mitochondrial Dysfunction in Post-COVID Fatigue and Cancer Fatigue. | UNKNOWN | nan | National University Hospital, Singapore | MRI/ 3D Arterial Spin Labelling (ASL) and 1H magnetic resonance spectroscopy (MRS); Chalder Fatigue Scale; Health Questionnaire (EQ-5D-5L); Hamilton Depression |
| NCT04349605 | Meditation and Yoga for Patients With Persistent Symptoms After Lyme Disease | WITHDRAWN | nan | Research Foundation for Mental Hygiene, Inc. | Meditation; Kundalini Yoga |
| NCT05130736 | The Use of a Rehabilitation Robot in Patients With Post-COVID-19 Fatigue Syndrome | UNKNOWN | nan | Poznan University of Medical Sciences | Robot rehabilitation |
| ID | Title | Year | Journal | Source | Linked NCTs |
|---|---|---|---|---|---|
| PMID:31669585.0 | Characterization of 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidases from Borrelia burgdorferi: Antibiotic targets for Lyme disease. | 2020 | Biochimica et biophysica acta. General subjects | PubMed | nan |
| PMID:31707447.0 | Delayed diagnosis of posterior ankle impingement in pediatric and adolescent patients: does radiology play a role? | 2020 | Pediatric radiology | PubMed | nan |
| PMID:31713746.0 | Management of anticoagulated patients in dentoalveolar surgery: a clinical comparative study. | 2020 | Clinical oral investigations | PubMed | nan |
| PMID:31924165.0 | The pan-genome of Treponema pallidum reveals differences in genome plasticity between subspecies related to venereal and non-venereal syphilis. | 2020 | BMC genomics | PubMed | nan |
| PMID:32099421.0 | Virulence and Resistance Determinants of Uropathogenic Escherichia coli Strains Isolated from Pregnant and Non-Pregnant Women from Two States in Mexico. | 2020 | Infection and drug resistance | PubMed | nan |
| PMID:32102582.0 | CD30 expression and survival in posttransplant lymphoproliferative disorders. | 2020 | Acta oncologica (Stockholm, Sweden) | PubMed | nan |
| PMID:32123189.0 | Azlocillin can be the potential drug candidate against drug-tolerant Borrelia burgdorferi sensu stricto JLB31. | 2020 | Scientific reports | Europe PMC; PubMed | nan |
| PMID:32161761.0 | Post-treatment Lyme Disease as a Model for Persistent Symptoms in Lyme Disease. | 2020 | Frontiers in medicine | PubMed | nan |
| PMID:32181254.0 | Borrelia miyamotoi: 43 Cases Diagnosed in France by Real-Time PCR in Patients With Persistent Polymorphic Signs and Symptoms. | 2020 | Frontiers in medicine | PubMed | nan |
| PMID:32258940.0 | Synthesis of Novel Thermostable Polyamideimides from Bis(2-aminoethyl)terephthalamide and Dianhydrides. | 2020 | ACS omega | PubMed | nan |
| PMID:32407047.0 | Post-heart transplantation lymphoproliferative diseases (PTLDs) and the diagnostic role of [18f] FDG-PET/CT. | 2021 | Minerva medica | PubMed | nan |
| PMID:32409277.0 | Community perspectives on difference of sex development (DSD) diagnoses: A crowdsourced survey. | 2020 | Journal of pediatric urology | PubMed | nan |
| PMID:32425371.0 | Post Transplant Lymphoproliferative Disorder. | 2020 | Indian journal of hematology & blood transfusion : an official journal of Indian Society of Hema | PubMed | nan |
| PMID:32457042.0 | Lyme borreliosis: diagnosis and management. | 2020 | BMJ (Clinical research ed.) | PubMed | nan |
| PMID:32505105.0 | Generation of human induced pluripotent stem cell (SKLRMi001-A) from a patient with partial androgen insensitivity syndrome (PAIS). | 2020 | Stem cell research | PubMed | nan |
| PMID:32651631.0 | The safety and efficacy of one-stage posterior surgery in the treatment of presumed adolescent idiopathic scoliosis associated with intraspinal abnormalities a minimum 3-year follow-up comparative study. | 2021 | European spine journal : official publication of the European Spine Society, the European Spinal Def | PubMed | nan |
| PMID:32793063.0 | Illness Perception in Adolescent Patients With Anorexia: Does It Play a Role in socio-Emotional and Academic Adjustment? | 2020 | Frontiers in psychology | PubMed | nan |
| PMID:32858987.0 | Evaluation of Disulfiram Drug Combinations and Identification of Other More Effective Combinations against Stationary Phase Borrelia burgdorferi. | 2020 | Antibiotics (Basel, Switzerland) | Europe PMC; PubMed | nan |
| PMID:32864761.0 | The clinical and pathological features of plasma cell myeloma post solid organ transplantation. | 2020 | American journal of hematology | PubMed | nan |
| PMID:32903720.0 | Methanolic Extract of Winter Cherry Causes Morpho-Histological and Immunological Ailments in Mulberry Pyralid Glyphodes pyloalis. | 2020 | Frontiers in physiology | PubMed | nan |
| PMID:32975577.0 | Metabolic Response in Patients With Post-treatment Lyme Disease Symptoms/Syndrome. | 2021 | Clinical infectious diseases : an official publication of the Infectious Diseases Society of America | Europe PMC; PubMed | nan |
| PMID:32991035.0 | Assessment and characterisation of post-COVID-19 manifestations. | 2021 | International journal of clinical practice | PubMed | nan |
| PMID:32994327.0 | A Distinct Microbiome Signature in Posttreatment Lyme Disease Patients. | 2020 | mBio | Europe PMC; OpenAlex; PubMed | nan |
| PMID:33042147.0 | Management of PTLD After Hematopoietic Stem Cell Transplantation: Immunological Perspectives. | 2020 | Frontiers in immunology | PubMed | nan |
| PMID:33057766.0 | Malignancies after pediatric solid organ transplantation. | 2021 | Pediatric nephrology (Berlin, Germany) | PubMed | nan |
| PMID:33082098.0 | Endoscopy for the treatment of posterior ankle impact syndrome: Learning curve. | 2021 | Foot and ankle surgery : official journal of the European Society of Foot and Ankle Surgeons | PubMed | nan |
| PMID:33126203.0 | Classification of patients referred under suspicion of tick-borne diseases, Copenhagen, Denmark. | 2021 | Ticks and tick-borne diseases | PubMed | nan |
| PMID:33166287.0 | Persistent fatigue following SARS-CoV-2 infection is common and independent of severity of initial infection. | 2020 | PloS one | PubMed | nan |
| PMID:33168903.0 | Evaluation of pathogen specific urinary peptides in tick-borne illnesses. | 2020 | Scientific reports | Europe PMC; PubMed | nan |
| PMID:33195313.0 | Borrelia miyamotoi Serology in a Clinical Population With Persistent Symptoms and Suspected Tick-Borne Illness. | 2020 | Frontiers in medicine | PubMed | nan |
| PMID:33196946.0 | COVID-19 and nutriceutical therapies, especially using zinc to supplement antimicrobials. | 2021 | Inflammopharmacology | PubMed | nan |
| PMID:33261237.0 | Lessons Learned from a Rhode Island Academic Out-Patient Lyme and Tick-Borne Disease Clinic. | 2020 | Rhode Island medical journal (2013) | PubMed | nan |
| PMID:33291557.0 | "Repurposing" Disulfiram in the Treatment of Lyme Disease and Babesiosis: Retrospective Review of First 3 Years' Experience in One Medical Practice. | 2020 | Antibiotics (Basel, Switzerland) | PubMed | nan |
| PMID:33303701.0 | Lyme Disease in Humans. | 2021 | Current issues in molecular biology | PubMed | nan |
| PMID:33322316.0 | Could Cognitive Behavioural Therapy Be an Effective Treatment for Long COVID and Post COVID-19 Fatigue Syndrome? Lessons from the Qure Study for Q-Fever Fatigue Syndrome. | 2020 | Healthcare (Basel, Switzerland) | PubMed | nan |
| PMID:33401106.0 | COVID-19 and chronic fatigue syndrome: Is the worst yet to come? | 2021 | Medical hypotheses | PubMed | nan |
| PMID:33468708.0 | Continuous Genomic Surveillance Monitored the In Vivo Evolutionary Trajectories of Vibrio parahaemolyticus and Identified a New Virulent Genotype. | 2021 | mSystems | PubMed | nan |
| PMID:33521196.0 | Intraarticular Pain Catheter Is Not a Necessary Modality for Postoperative Pain Control After Total Knee Arthroplasty. | 2021 | Arthroplasty today | PubMed | nan |
| PMID:33557013.0 | Diagnostic and Pharmacological Potency of Creatine in Post-Viral Fatigue Syndrome. | 2021 | Nutrients | Europe PMC; PubMed | nan |
| PMID:33621411.0 | Distinct immunopathological mechanisms of EBV-positive and EBV-negative posttransplant lymphoproliferative disorders. | 2021 | American journal of transplantation : official journal of the American Society of Transplantation an | PubMed | nan |
| PMID:33706852.0 | Corticosteroid Injections in Posterior Ankle Impingement Syndrome: A Survey of Professional and Elite Student Ballet Dancers. | 2021 | Journal of dance medicine & science : official publication of the International Association for | PubMed | nan |
| PMID:33709142.0 | PREVAIL IV: A Randomized, Double-Blind, 2-Phase, Phase 2 Trial of Remdesivir vs Placebo for Reduction of Ebola Virus RNA in the Semen of Male Survivors. | 2021 | Clinical infectious diseases : an official publication of the Infectious Diseases Society of America | PubMed | nan |
| PMID:33735220.0 | A comprehensive clinical and laboratory evaluation of 224 patients with persistent symptoms attributed to presumed tick-bite exposure. | 2021 | PloS one | Europe PMC; PubMed | nan |
| PMID:33763080.0 | Predicting Lyme Disease From Patients' Peripheral Blood Mononuclear Cells Profiled With RNA-Sequencing. | 2021 | Frontiers in immunology | PubMed | nan |
| PMID:33774355.0 | Evaluation of selected variables to determine if any had predictive value for, or correlated with, residual symptoms at approximately 12 months after diagnosis and treatment of early Lyme disease. | 2021 | Diagnostic microbiology and infectious disease | Europe PMC; PubMed | nan |
| PMID:33781531.0 | Central Nervous System Involvement in Epstein-Barr Virus-Related Post-Transplant Lymphoproliferative Disorders after Allogeneic Hematopoietic Stem Cell Transplantation. | 2021 | Transplantation and cellular therapy | Europe PMC; PubMed | nan |
| PMID:33789412.0 | Characterizing the Symptoms of Patients with Persistent Post-Treatment Lyme Symptoms: A Survey of Patients at a Lyme Disease Clinic in Rhode Island. | 2021 | Rhode Island medical journal (2013) | PubMed | nan |
| PMID:33793378.0 | Prior antithymocyte globulin therapy and survival in post-transplant lymphoproliferative disorders. | 2021 | Acta oncologica (Stockholm, Sweden) | PubMed | nan |
| PMID:33921413.0 | Natural Killer Cells in Post-Transplant Lymphoproliferative Disorders. | 2021 | Cancers | PubMed | nan |
| PMID:33937363.0 | A Serpin With a Finger in Many PAIs: PAI-1's Central Function in Thromboinflammation and Cardiovascular Disease. | 2021 | Frontiers in cardiovascular medicine | PubMed | nan |
Detection of digital, voice, patient-reported, and functional readouts in the corpus. 1334 of 8405 records mention at least one modality. Sparse groups are themselves a finding — they flag measurement strategies the current corpus barely covers, and may motivate the next round of search refinement.
| NCT ID | Title | Status | Phase | Sponsor | Intervention |
|---|---|---|---|---|---|
| NCT05576662 | Selective Trial Of Paxlovid for PASC (STOP-PASC): Randomized Double-Blind Placebo-Controlled Pilot Trial of Paxlovid for the Treatment of PASC | COMPLETED | PHASE2 | Stanford University | Nirmatrelvir; Placebo; Ritonavir |
| NCT04141696 | A Proof-of-Concept Trial on the Effect of Ketamine on Fatigue | COMPLETED | PHASE1; PHASE2 | National Institute of Nursing Research (NINR) | Ketamine; Midazolam |
| NCT05199233 | The Benefit of Mindfulness-Based Intervention Using A Wearable Wellness Brain Sensing Device (Muse-S™) in the Treatment of Post-Covid Symptoms | COMPLETED | nan | Mayo Clinic | Muse S™ Headband system |
| NCT05205460 | Effectiveness of a 12-week Telerehabilitation Training in People With Long COVID: A Randomized Controlled Trial | COMPLETED | nan | Tri-Service General Hospital | Home-based telerehabilitation; Education and self-exercise |
| NCT05597722 | Randomized Study to Evaluate Strategies to Address Cognitive Fog in Long-COVID-19 Patients | TERMINATED | PHASE4 | Eva Szigethy | Digital cognitive behavioral intervention-RxWell; Amphetamine-Dextroamphetamine |
| NCT06404112 | RECOVER-SLEEP: A Platform Protocol for Evaluation of Interventions for Sleep Disturbances in Post-Acute Sequelae of SARS-CoV-2 Infection (PASC) | COMPLETED | PHASE2 | Duke University | Melatonin; Melantonin Placebo; Tailored lighting (TL) Active; Tailored lighting (TL) Placebo |
| NCT04997395 | Safety and Tolerability of Full Spectrum Cannabidiol Dominant Medicinal Cannabis in Treating Symptoms Associated With Long COVID: A Feasibility Study | COMPLETED | PHASE2 | Bod Australia | MediCabilis Cannabis sativa 50 |
| NCT05228899 | A Phase I/II Multicenter, Randomized, Double Blinded, Placebo Trial to Evaluate the Safety and Potential Efficacy of Zofin Infused Intravenous (IV) in Patients Experiencing Prolong | COMPLETED | PHASE1; PHASE2 | ZEO ScientifiX, Inc. | Zofin; Placebo |
| NCT06840873 | Effectiveness of a 8-week Tele-Rehabilitative Exercise Training Program on Fatigue, Symptom Severity, and Quality of Life in Nurses With Long COVID: A Randomized Controlled Trial | COMPLETED | nan | Shang-Lin Chiang | wearable device; Healthy consulation |
| NCT06404073 | RECOVER-ENERGIZE: A Platform Protocol for Evaluation of Interventions for Exercise Intolerance in Post-Acute Sequelae of SARS-CoV-2 Infection (PASC) | COMPLETED | nan | Duke University | Structured Pacing; Usual Care |
| NCT05194059 | ActiPacMAN: 'Activity Pacing' in PLWH With Fatigue Symptoms. Monitoring Through the Combined Use of Actigraphy and Mobile App Notifications | COMPLETED | nan | Scientific Institute San Raffaele | Home-based physical activity |
| NCT05848401 | Biosound Therapy as a Treatment for Long COVID Patients: A Randomized Pilot Trial | COMPLETED | nan | Anxiety Relief Center | Biosound Therapy System |
| NCT05679505 | Effects of Vagus Nerve Stimulation in Post-COVID-19 Syndrome: A Randomized Controlled Trial | COMPLETED | nan | Bahçeşehir University | Auricular transcutaneous vagus nerve stimulation |
| NCT05218174 | Exercise Training and Functional, Cognitive, and Emotional Well-being in Adults with Post-Acute Sequelae of SARS-CoV-2 (COVID-19) Infection (PASC): a Randomized Controlled Trial | COMPLETED | nan | Baylor Research Institute | Exercise Prescription |
| NCT05973136 | A Pilot Study to Evaluate the Implantation and the Impact of a Hybrid Telerehabilitation Program Based on Cardiopulmonary Rehabilitation Principles for People With Post-COVID Affec | COMPLETED | nan | Université de Sherbrooke | Telerehabilitation program based on cardiorespiratory principles |
| NCT05389592 | Treatment of COVID-19 Post-acute Cognitive Impairment Sequelae (PASC) With Portable Brain Stimulation: a Double-blind, Randomized-controlled Trial | COMPLETED | nan | University of Sao Paulo | Active tDCS and cognitive training; Sham tDCS and cognitive training |
| NCT06393790 | Health Effects of a Strength Training Protocol in Women With Fibromyalgia and Healthy Individuals. | COMPLETED | nan | Catholic University of Murcia | FMG (Fibromyalgia group); HG (Healthy group) |
| NCT05273372 | A Randomized Double Blind Placebo Controlled Trial to Determine the Effects of Oxaloacetate on Improving Fatigue in ME/CFS | COMPLETED | nan | Terra Biological LLC | Placebo; Medical Food - Anhydrous Enol-Oxaloacetate |
| NCT05282199 | Efficacy of Inspiratory Muscle Training (IMT) on Sleep Quality, Exercise Tolerance and Pulmonary Radioaerosol Deposition Pattern in Post COVID-19 Infection Subjects | COMPLETED | nan | Universidade Federal de Pernambuco | INSPIRATORY MUSCLE TRAINING |
| NCT07190105 | Impact of Vagal Approaches on Symptomatology in Long COVID Participants | COMPLETED | nan | Leidos Life Sciences | Sonocea Sonic Augmentation Technology (SAT); Truvaga Electrical Vagus Nerve Stimulator |
| NCT05648123 | Effectiveness of Supportive Psychotherapy Through Internet-Based Teleconsultation on Psychological and Somatic Symptoms, Neutrophil-Lymphocyte Ratio, and Heart Rate Variability in | COMPLETED | nan | Indonesia University | Supportive Psychotherapy |
| NCT06305793 | RECOVER-AUTONOMIC (IVIG): Randomized Trial of the Effect of IVIG Versus Placebo on Long COVID Symptoms | ACTIVE_NOT_RECRUITING | PHASE2 | Kanecia Obie Zimmerman | IVIG (intravenous immunoglobulin); IVIG Placebo; Coordinated Care; Usual Care |
| NCT05793736 | A Feasibility Study of an HVR Protocol Biofeedback Training to Manage Long Covid Syndrome Symptoms | COMPLETED | nan | University of Cagliari | Biofeedback training; Treatment as usual |
| NCT05631171 | COVIDAI: Feasibility Study of Adhera® Fatigue Digital Program for Patients With Long COVID-related Fatigue | COMPLETED | nan | Adhera Health, Inc. | Adhera® Fatigue Digital Program |
| NCT05922865 | Tri-service General Hospital, National Defence Medical Center, Taipei, Taiwan | COMPLETED | nan | Shang-Lin Chiang | KNEESUP smart knee assistive device + KNEESUP care APP; Healthy consulation |
| NCT06635928 | Assessing Fatigue and Attention in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Patients Before and After Treatment With Bright Light Therapy: a Prospective Randomized Contro | COMPLETED | nan | Medical University of Vienna | Bright light therapy |
| NCT05003271 | Pulmonary Rehabilitation Post-COVID-19: a Pilot Study | COMPLETED | nan | University of Manitoba | Exercise program (virtual/remote) |
| NCT05001542 | Could Digital Interventions Help Understand And "Flatten The Curve" Of Distress Due To Moral Injury Among Health Care Workers During The COVID Pandemic? | COMPLETED | nan | Unity Health Toronto | Educational moral injury video |
| NCT06575920 | Breathing Therapy for Patients With Medically Unexplained Physical Symptoms and Dysfunctional Breathing: A Pilot and Feasibility Study | COMPLETED | nan | University of Agder | Breathing excercizes |
| NCT04794036 | Efficacy of an Asynchronous Telerehabilitation Programme in Post-COVID-19 Patients: a Feasibility Study | COMPLETED | nan | Universidad San Jorge | Asynchronous telerehabilitation programme; Rehabilitation programme |
| NCT05507190 | Self-management of Post COVID-19 Syndrome Using Wearable Biometric Technology | COMPLETED | nan | University of Manitoba | Self-management of post COVID-19 respiratory outcomes |
| NCT05483829 | AIDA - A Digital Health Intervention Based on Artificial Intelligence to Support the Personalized Recovery of Long COVID Patients: Feasibility Study. | COMPLETED | nan | Adhera Health, Inc. | Adhera® Fatigue for Long COVID program |
| NCT05172206 | Symptom-based Rehabilitation Compared to Usual Care in Post-COVID - a Randomized Controlled Trial | COMPLETED | nan | Schön Klinik Berchtesgadener Land | symptom-focused rehabilitation; usual care |
| NCT06189066 | Long COVID Ultrasound Trial [LOCUS Trial] | COMPLETED | nan | SecondWave Systems Inc. | Splenic Ultrasound |
| NCT05204511 | Exercise and Post-COVID/Long-COVID: Effects of Different Training Modalities on Physical Performance, Heart Rate Variability, Inflammation, Health-Related Quality of Life, Cognitiv | COMPLETED | nan | University of Vienna | endurance training; concurrent training |
| NCT05225220 | Multimodal Investigation of Post COVID-19 in Females: A Pilot Study | COMPLETED | nan | Casa Colina Hospital and Centers for Healthcare | Parasym Device (of Parasym Ltd, UK) using Transcutaneous Vagus Nerve Stimulation (t-VNS) |
| NCT06601920 | A Study of Activity Leader to Forest Therapy Campaign in Different Environments Targets on the Participants Which Had Been Infected by SARS-COV-2 | COMPLETED | nan | Taipei City Hospital | Forest healing activities |
| NCT06296914 | Developing and Testing a Mobile Health System for Patients with Postural Orthostatic Tachycardia Syndrome (POTS) | COMPLETED | nan | Jami Warren | POTSapp; Waitlist Control |
| NCT06404060 | RECOVER-ENERGIZE: A Platform Protocol for Evaluation of Interventions for Exercise Intolerance in Post-Acute Sequelae of SARS-CoV-2 Infection (PASC) | ACTIVE_NOT_RECRUITING | nan | Duke University | Personalized Cardiopulmonary Rehabilitation; Education |
| NCT05043051 | Autoimmune Basis for Postural Tachycardia Syndrome | ACTIVE_NOT_RECRUITING | nan | University of Oklahoma | Vagal stimulation; Sham stimulation |
| NCT06073886 | Personalized Circuit-Based Frontoamygdala Neuromodulation for Persistent Post-Concussive Symptoms | RECRUITING | PHASE2 | University of California, Los Angeles | Active cTBS; Inactive/Sham cTBS; Imaginal exposure |
| NCT06978582 | Effectiveness and Safety of a Tele-rehabilitation Program Based on Mindful and Conscious Movement-based Exercise vs Conventional Low-intensity Exercise on Fatigue and Related Varia | ACTIVE_NOT_RECRUITING | nan | University of Seville | Mindful and conscious movement-based exercise; Conventional exercise |
| NCT04186286 | A Randomized Crossover Study of Propranolol Versus Ivabradine in Postural Tachycardia Syndrome (POTS) | RECRUITING | PHASE2 | University of Calgary | Ivabradine 4-week course; Propranolol 4-week course; Placebo 4-week course |
| NCT06968104 | Stimulation of the Transcutaneous Auricular Vagus Nerve for Improvement of Symptoms in Patients With Post-COVID Syndrome and ME/CFS | ACTIVE_NOT_RECRUITING | nan | University of Luxembourg | transcutaneous vagus nerve stimulation; transcutaneous vagus nerve stimulation |
| NCT06366724 | LIFT: Life Improvement Trial | RECRUITING | PHASE2 | Brigham and Women's Hospital | Pyridostigmine; Low-Dose Naltrexone; Placebo |
| NCT04935307 | Central Processing of Odour Stimuli in Patients With Multi-systemic Functional Somatic Disorder, Multiple Chemical Sensitivityor Post Covid Compared to Healthy Controls - the Pilot | ACTIVE_NOT_RECRUITING | nan | University of Aarhus | MRI and paraclinical tests |
| NCT05445830 | Physiological Characterization of Functional Limitations and Exercise Intolerance in Post-COVID Patients | ACTIVE_NOT_RECRUITING | nan | Karolinska Institutet | High-Intensity-Interval-Exercise; Moderate-Intensity-Continuous-Exercise; Strength training; Baseline assessment; 1 year follow-up |
| NCT06655844 | Extended Home-use Trial of a Novel Device to Reduce Chronic Pain | RECRUITING | nan | Icahn School of Medicine at Mount Sinai | Sana Pain Reliever; Sham SPR |
| NCT06168006 | Effects of a Physical Training Program Using a Mobile App on the Functionality and Cardiovascular Function of Individuals With Post-covid-19 Syndrome: Randomized Clinical Trial | RECRUITING | nan | University of Nove de Julho | Exercise; Control |
| NCT06967428 | Effectiveness of Metabolic Modulation in Treating Post-vaccination Syndrome: A Prospective Study | NOT_YET_RECRUITING | PHASE2 | Independent Medical Alliance | Combined metabolic modulator; Rice Protein Powder with Vitamin C |
| ID | Title | Year | Journal | Source | Linked NCTs |
|---|---|---|---|---|---|
| PMID:31957647.0 | Parasympathetic activity is reduced during slow-wave sleep, but not resting wakefulness, in patients with chronic fatigue syndrome. | 2020 | Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Me | PubMed | nan |
| PMID:32080891.0 | Tossing and Turning in Bed: Nocturnal Movements in Parkinson's Disease. | 2020 | Movement disorders : official journal of the Movement Disorder Society | PubMed | nan |
| PMID:32358461.0 | Heart Rate Variability Analysis: A Useful Tool to Assess Poststroke Cardiac Dysautonomia. | 2020 | The neurologist | PubMed | nan |
| PMID:32504895.0 | Patterns of daytime physical activity in patients with chronic fatigue syndrome. | 2020 | Journal of psychosomatic research | PubMed | nan |
| PMID:32857640.0 | Fatigue-Related Cognitive-Behavioral Factors in Survivors of Childhood Cancer: Comparison with Chronic Fatigue Syndrome and Survivors of Adult-Onset Cancer. | 2021 | Journal of adolescent and young adult oncology | PubMed | nan |
| PMID:32981583.0 | Autonomic Rehabilitation: Adapting to Change. | 2020 | Physical medicine and rehabilitation clinics of North America | PubMed | nan |
| PMID:33024503.0 | Defining Cardiac Dysautonomia - Different Types, Overlap Syndromes; Case-based Presentations. | 2020 | Journal of atrial fibrillation | Europe PMC; PubMed | nan |
| PMID:33103132.0 | Interference between rhinovirus and influenza A virus: a clinical data analysis and experimental infection study. | 2020 | The Lancet. Microbe | PubMed | nan |
| PMID:33168001.0 | Accurate and objective determination of myalgic encephalomyelitis/chronic fatigue syndrome disease severity with a wearable sensor. | 2020 | Journal of translational medicine | PubMed | nan |
| PMID:33264751.0 | Towards personalized assessment of fatigue perpetuating factors in patients with chronic fatigue syndrome using ecological momentary assessment: A pilot study. | 2021 | Journal of psychosomatic research | PubMed | nan |
| PMID:33400783.0 | Long-Term Influence of Concussion on Cardio-Autonomic Function in Adolescent Hockey Players. | 2021 | Journal of athletic training | PubMed | nan |
| PMID:33417078.0 | Chemotherapy and Radiation-Associated Cardiac Autonomic Dysfunction. | 2021 | Current oncology reports | PubMed | nan |
| PMID:33425945.0 | Obstacles and Considerations Related to Clinical Trial Research During the COVID-19 Pandemic. | 2020 | Frontiers in medicine | PubMed | nan |
| PMID:33862302.0 | Emotional Behavioural and Autonomic Dysregulation (EBAD) in Rett Syndrome - EDA and HRV monitoring using wearable sensor technology. | 2021 | Journal of psychiatric research | PubMed | nan |
| PMID:33918854.0 | Evaluation of E-Health Applications for Paediatric Patients with Refractory Epilepsy and Maintained on Ketogenic Diet. | 2021 | Nutrients | PubMed | nan |
| PMID:34178579.0 | A new privacy framework for the management of chronic diseases via mHealth in a post-Covid-19 world. | 2022 | Zeitschrift fur Gesundheitswissenschaften = Journal of public health | PubMed | nan |
| PMID:34179343.0 | Trending Technology of Glucose Monitoring during COVID-19 Pandemic: Challenges in Personalized Healthcare. | 2021 | Advanced materials technologies | PubMed | nan |
| PMID:34481597.0 | Increased Utilization of Virtual Visits and Electronic Approaches in Clinical Research During the COVID-19 Pandemic and Thereafter. | 2021 | Mayo Clinic proceedings | PubMed | nan |
| PMID:34602086.0 | Cognitive-behavioral therapy for management of mental health and stress-related disorders: Recent advances in techniques and technologies. | 2021 | BioPsychoSocial medicine | PubMed | nan |
| PMID:34665645.0 | Can Remote Patient Monitoring Be the New Standard in Primary Care of Chronic Diseases, Post-COVID-19? | 2022 | Telemedicine journal and e-health : the official journal of the American Telemedicine Association | PubMed | nan |
| PMID:34948285.0 | Cardiac Changes in Parkinson's Disease: Lessons from Clinical and Experimental Evidence. | 2021 | International journal of molecular sciences | PubMed | nan |
| PMID:34957011.0 | Changes in Quality of Life and Loneliness Among Middle-Aged and Older Adults Participating in Therapist-Guided Digital Mental Health Intervention. | 2021 | Frontiers in public health | PubMed | nan |
| PMID:34975538.0 | Central Hypovolemia Detection During Environmental Stress-A Role for Artificial Intelligence? | 2021 | Frontiers in physiology | PubMed | nan |
| PMID:34982039.0 | An mHealth App for Fibromyalgia-like Post-COVID-19 Syndrome: Protocol for the Analysis of User Experience and Clinical Data. | 2022 | JMIR research protocols | PubMed | nan |
| PMID:35171410.0 | Cardiovascular Autonomic Regulation, ETCO2 and the Heart Rate Response to the Tilt Table Test in Patients with Orthostatic Intolerance. | 2022 | Applied psychophysiology and biofeedback | PubMed | nan |
| PMID:35326943.0 | The Effect of Telemonitoring (TM) on Improving Adherence with Continuous Positive Airway Pressure (CPAP) in Obstructive Sleep Apnoea (OSA): A Service Improvement Project (SIP). | 2022 | Healthcare (Basel, Switzerland) | PubMed | nan |
| PMID:35360739.0 | Applications of Artificial Intelligence in Myopia: Current and Future Directions. | 2022 | Frontiers in medicine | PubMed | nan |
| PMID:35394733.0 | [Current concepts about autonomic dysfunction in patients with epilepsy]. | 2022 | Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova | PubMed | nan |
| PMID:35473737.0 | Therapies for Long COVID in non-hospitalised individuals: from symptoms, patient-reported outcomes and immunology to targeted therapies (The TLC Study). | 2022 | BMJ open | PubMed | nan |
| PMID:35506018.0 | Exploring the Impact and Acceptance of Wearable Sensor Technology for Pre- and Postoperative Rehabilitation in Knee Replacement Patients: A U.K.-Based Pilot Study. | 2022 | JB & JS open access | PubMed | nan |
| PMID:35632776.0 | Impaired Vagal Activity in Long-COVID-19 Patients. | 2022 | Viruses | PubMed | nan |
| PMID:35711362.0 | Repostioning of Telemedicine in Cardiovascular World Post-COVID-19 Pandemic. | 2022 | Frontiers in cardiovascular medicine | PubMed | nan |
| PMID:36002874.0 | A pilot randomized controlled trial of supervised, at-home, self-administered transcutaneous auricular vagus nerve stimulation (taVNS) to manage long COVID symptoms. | 2022 | Bioelectronic medicine | OpenAlex; PubMed | nan |
| PMID:35787520.0 | Equity and Accessibility of Washington State's COVID-19 Digital Exposure Notification Tool (WA Notify): Survey and Listening Sessions Among Community Leaders. | 2022 | JMIR formative research | PubMed | nan |
| PMID:35960595.0 | A Digital Mental Health Intervention (Inuka) for Common Mental Health Disorders in Zimbabwean Adults in Response to the COVID-19 Pandemic: Feasibility and Acceptability Pilot Study. | 2022 | JMIR mental health | OpenAlex; PubMed | nan |
| PMID:36090762.0 | Strategies for Cardio-Oncology Care During the COVID-19 Pandemic. | 2022 | Current treatment options in cardiovascular medicine | PubMed | nan |
| PMID:36151442.0 | Coexistence of fibromyalgia syndrome and inflammatory rheumatic diseases, and autonomic cardiovascular system involvement in fibromyalgia syndrome. | 2023 | Clinical rheumatology | PubMed | nan |
| PMID:36227021.0 | Smart healthcare: A prospective future medical approach for COVID-19. | 2023 | Journal of the Chinese Medical Association : JCMA | PubMed | nan |
| PMID:36298551.0 | Dysautonomia in Children with Post-Acute Sequelae of Coronavirus 2019 Disease and/or Vaccination. | 2022 | Vaccines | Europe PMC; PubMed | nan |
| PMID:36352579.0 | Cardiovascular Autonomic Assessment in Guillain-Barré Syndrome: A Longitudinal Study. | 2022 | Neurology India | PubMed | nan |
| PMID:36371084.0 | Autonomic nerve regulation in joint hypermobility patients with myofascial trigger points by Musculoskeletal Interfiber Counterirritant Stimulation (MICS). | 2022 | Medical engineering & physics | PubMed | nan |
| PMID:36410797.0 | HEART rate variability biofeedback for long COVID symptoms (HEARTLOC): protocol for a feasibility study. | 2022 | BMJ open | Europe PMC; Preprint (medRxiv/bioRxiv); PubMed | NCT05228665 |
| PMID:36412474.0 | Impact of early pulmonary rehabilitation in postacute COVID Disease: A single-center experience from India - A quasi-experimental study. | 2022 | Indian journal of public health | PubMed | nan |
| PMID:36639565.0 | Heart rate variability responses to cognitive stress in fibromyalgia are characterised by inadequate autonomous system stress responses: a clinical trial. | 2023 | Scientific reports | Europe PMC; PubMed | nan |
| PMID:36716162.0 | Using telemedicine interventions during COVID-19 to expand care post COVID-19. | 2023 | The American journal of managed care | PubMed | nan |
| PMID:36779003.0 | Impact of COVID-19 Pandemic on Physical Activity, Pain, Mood, and Sleep in Adults with Knee Osteoarthritis. | 2022 | Journal for the measurement of physical behaviour | PubMed | nan |
| PMID:36832445.0 | Therapeutic Approaches to Dysautonomia in Childhood, with a Special Focus on Long COVID. | 2023 | Children (Basel, Switzerland) | Europe PMC; OpenAlex; PubMed | nan |
| PMID:36873318.0 | Low-level tragus stimulation improves autoantibody-induced hyperadrenergic postural tachycardia syndrome in rabbits. | 2023 | Heart rhythm O2 | Europe PMC; OpenAlex; PubMed | nan |
| PMID:36923369.0 | Can digital health apps provide patients with support to promote structured diabetes education and ongoing self-management? A real-world evaluation of myDiabetes usage. | 2023 | Digital health | PubMed | nan |
| PMID:37020492.0 | A descriptive study of the clinical impacts on COVID-19 survivors using telemonitoring (The TeleCOVID Study). | 2023 | Frontiers in medical technology | PubMed | nan |
| NCT ID | Title | Status | Phase | Sponsor | Intervention |
|---|---|---|---|---|---|
| NCT05629793 | Differential Diagnosis of Persistent COVID-19 by Artificial Intelligence | UNKNOWN | nan | Fundacin Biomedica Galicia Sur | Experimental tests |
| ID | Title | Year | Journal | Source | Linked NCTs |
|---|---|---|---|---|---|
| PMID:39721883.0 | Evaluation of Vocal and Pulmonary Health Through Acoustic Analysis of Voice and Respiratory Measurements in People With Long COVID-19 Symptoms. | 2024 | Journal of voice : official journal of the Voice Foundation | PubMed | nan |
| PMID:40426703.0 | Digital Biomarkers and AI for Remote Monitoring of Fatigue Progression in Neurological Disorders: Bridging Mechanisms to Clinical Applications. | 2025 | Brain sciences | PubMed | nan |
| NCT ID | Title | Status | Phase | Sponsor | Intervention |
|---|---|---|---|---|---|
| NCT05104749 | Homeopathic Treatment of Post-acute COVID-19 Syndrome- A Pilot Randomized Controlled Trial | COMPLETED | PHASE3 | Southwest College of Naturopathic Medicine | Homeopathic Medication; Placebo |
| NCT05999435 | A DOUBLE-BLIND, RANDOMIZED, PLACEBO-CONTROLLED, ADAPTIVE PHASE 2/3 STUDY OF THE EFFICACY OF LAU-7b IN THE TREATMENT OF ADULTS WITH LONG COVID AND MODERATE TO SEVERE SYMPTOMS | COMPLETED | PHASE2; PHASE3 | Laurent Pharmaceuticals Inc. | LAU-7b for 3 cycles; LAU-7b for 1 cycle, then placebo; Placebo for 3 cycles |
| NCT05074888 | A Multicenter, Double-blind, Placebo-controlled, Parallel-group, Randomized Clinical Trial of Efficacy and Safety of Prospekta in the Treatment of Patients With Post-COVID-19 Asthe | COMPLETED | PHASE3 | Materia Medica Holding | Prospekta; Placebo |
| NCT05633407 | A Phase 2 Randomized, Double-blinded, Placebo-controlled Study to Evaluate the Efficacy and Safety of Efgartigimod IV in Adult Patients With Post-COVID-19 Postural Orthostatic Tach | COMPLETED | PHASE2 | argenx | Efgartigimod; Placebo |
| NCT05618587 | Effect of Low-dose Lithium Therapy on Long COVID Symptoms: a Randomized Controlled Trial. | COMPLETED | PHASE2 | State University of New York at Buffalo | Lithium; Placebo |
| NCT05592418 | A Randomized, Double Blind, Placebo Controlled Study to Evaluate the Efficacy and Safety of Ampligen® in Patients With Post-COVID Conditions | COMPLETED | PHASE2 | AIM ImmunoTech Inc. | Rintatolimod; Placebo / Normal Saline |
| NCT05576662 | Selective Trial Of Paxlovid for PASC (STOP-PASC): Randomized Double-Blind Placebo-Controlled Pilot Trial of Paxlovid for the Treatment of PASC | COMPLETED | PHASE2 | Stanford University | Nirmatrelvir; Placebo; Ritonavir |
| NCT04141696 | A Proof-of-Concept Trial on the Effect of Ketamine on Fatigue | COMPLETED | PHASE1; PHASE2 | National Institute of Nursing Research (NINR) | Ketamine; Midazolam |
| NCT06133075 | Using Mirabegron to Increase Blood Pressure in Patients With Postural Orthostatic Tachycardia Syndrome | COMPLETED | PHASE2 | Cedars-Sinai Medical Center | Mirabegron 50 MG; Mirabegron 25 MG |
| NCT05965726 | RECOVER-VITAL: A Platform Protocol for Evaluation of Interventions for Viral Persistence, Viral Reactivation, and Immune Dysregulation in Post-Acute Sequelae of SARS-CoV-2 Infectio | COMPLETED | PHASE2 | Kanecia Obie Zimmerman | Paxlovid; Ritonavir; Nirmatrelvir-matching placebo |
| NCT05126563 | A Randomized, Double-blinded, Single-center, Phase 2 Efficacy, and Safety Study of Allogeneic HB-adMSCs for the Treatment of Patients With Chronic Post-COVID-19 Syndrome. | COMPLETED | PHASE2 | Hope Biosciences Research Foundation | HB-adMSCs (allogeneic); Placebo |
| NCT05472090 | A Phase 2, 14-week Double-Blind, Randomized, Multicenter, Placebo-Controlled Study to Evaluate the Efficacy and Safety of TNX-102 SL Taken Daily at Bedtime in Patients With Multisi | COMPLETED | PHASE2 | Tonix Pharmaceuticals, Inc. | TNX-102 SL; Placebo SL Tablet |
| NCT06136871 | Cognitive Strategy Training in Post-COVID-19 Syndrome: A Feasibility Trial | COMPLETED | nan | University of Missouri-Columbia | CO-OP Procedures; Inactive Control Group |
| NCT06476496 | Pain Relief With Integrative Medicine (PRIMe)?: Feasibility of Acupuncture for Long COVID | COMPLETED | nan | University of Washington | Acupuncture |
| NCT05877508 | An Exploratory, Randomized, Double-Blind Placebo-Controlled Study to Assess the Safety of an Anti-SARS-CoV-2 Monoclonal Antibody and Response to Treatment in Individuals With Long | ACTIVE_NOT_RECRUITING | PHASE2 | Michael Peluso, MD | AER002; Placebo |
| NCT06161688 | Placebo-Controlled, Randomized Trial of Ensitrelvir (S-217622) for Viral Persistence and Inflammation in People Experiencing Long COVID (PREVAIL-LC) | ACTIVE_NOT_RECRUITING | PHASE2 | Timothy Henrich | Ensitrelvir; Placebo |
| NCT06268288 | Pilot Study--The Effects of Non-invasive Vagal Neurostimulation (nVNS) in Adolescents With Postural Orthostatic Tachycardia Syndrome (POTS) | COMPLETED | nan | Mayo Clinic | GammaCore intervention; STEPS management protocol |
| NCT05445427 | Outcomes of Treatment With Vagal Nerve Stimulation in Post-COVID Syndrome: A Pilot Study | COMPLETED | nan | Mayo Clinic | vagal nerve stimulator |
| NCT06208163 | Psychoneuroimmunology as a Framework for Studying the Effects of Chiropractic Care in a Population With High Central Adiposity: a Pilot Trial | COMPLETED | nan | Life University | Chiropractic |
| NCT05946551 | Feasibility Assessment of a Decentralized Platform Adaptive Double-Blind, Randomized Controlled Trial Investigating Repurposed Drugs in the Treatment of Post-Acute Sequelae of Coro | TERMINATED | PHASE3 | Emory University | Cetirizine; Famotidine; Cetirizine Placebo; Famotidine Placebo |
| NCT04313972 | IC PaIN Trial: Interstitial Cystitis Pain Improvement With Naltrexone, the Effect of Low Dose Naltrexone on Symptoms and Pain of Patients With Interstitial Cystitis/Painful Bladder | TERMINATED | PHASE4 | Endeavor Health | low-dose naltrexone; Placebo oral tablet |
| NCT05918978 | Open-Label Extension Study to Evaluate the Long-term Safety and Efficacy of Efgartigimod in Adult Patients With Post-COVID-19 Postural Orthostatic Tachycardia Syndrome (PC-POTS) Wh | TERMINATED | PHASE2 | argenx | Efgartigimod |
| NCT05513560 | REcovering From COVID-19 Lingering Symptoms Adaptive Integrative Medicine (RECLAIM) | COMPLETED | PHASE2; PHASE3 | University Health Network, Toronto | Ibudilast; Pentoxifylline; Placebo |
| NCT05638633 | Prednisolone and Vitamin B1, B6, and B12 in Patients With Post-COVID-19-Syndrome (PC19S) - a Randomized Controlled Trial in Primary Care | COMPLETED | PHASE3 | Wuerzburg University Hospital | Prednisolone 20 mg/ 5 mg; Vitamin B compound (100mg B1, 50 mg B6, 500 µg B12); Placebo for Vitamin B compound; Placebo for Prednisolon |
| NCT05939622 | Prospective Randomized Double Blind Placebo Controlled Study of Efficacy of the Therapy With BRAINMAX® Using Functional Magnetic Resonance Imaging (fMRI) for the Treatment of Patie | COMPLETED | PHASE4 | Promomed, LLC | Structural and functional MRI; Ethyl methyl hydroxypyridine succinate + Meldonium; Placebo |
| NCT05524532 | Effect of Immulina Supplements on Inflammatory Biomarkers Correlated With Clinical Symptoms in Patients With Long COVID (PASC) | COMPLETED | PHASE3 | University of Mississippi Medical Center | Immulina TM; Placebo |
| NCT04622293 | A Double-Blind, Randomized, Placebo-Controlled, Single-Center, Flexible Titration Study Evaluating the Efficacy of Solriamfetol in Treating Fatigue and Cognitive Symptoms in Adults | COMPLETED | PHASE4 | Rochester Center for Behavioral Medicine | Solriamfetol Oral Tablet [Sunosi]; Placebo |
| NCT06245642 | A Multi-center, Randomized, Double-blind, Positive Parallel Control Study of Compound Ciwujia Granules in the Treatment of Chronic Fatigue Syndrome (Spleen-kidney Deficiency Syndro | COMPLETED | PHASE4 | Heilongjiang Quanle Pharmaceutical Co., Ltd. | Compound Ciwujia Granules, Guipi Granules |
| NCT05890534 | Pycnogenol® in People With Post-COVID-19 Condition: a Quadruple-blind, Randomized, Placebo-controlled Trial | COMPLETED | PHASE3 | University of Zurich | Pycnogenol®; Placebo |
| NCT06128967 | An Adaptive, Randomized, doublE-blind, Placebo-controlled, Prospective, Pharmacological interVention Study In Participants With Long COVID-19 Syndrome: REVIVE-TOGETHER Trial | COMPLETED | PHASE3 | Cardresearch | Fluvoxamine Maleate 100 MG; Placebo; Metformin Extended Release Oral Tablet |
| NCT06404112 | RECOVER-SLEEP: A Platform Protocol for Evaluation of Interventions for Sleep Disturbances in Post-Acute Sequelae of SARS-CoV-2 Infection (PASC) | COMPLETED | PHASE2 | Duke University | Melatonin; Melantonin Placebo; Tailored lighting (TL) Active; Tailored lighting (TL) Placebo |
| NCT04705831 | A Randomized, Double Blind, Placebo Controlled, Cross-Over, Proof-of-Concept Study to Evaluate the Benefit of RUCONEST (C1 Esterase Inhibitor [Recombinant]) in Improving Neurologic | COMPLETED | PHASE2 | IMMUNOe Research Centers | Ruconest |
| NCT06316843 | A Randomized, Double-Blinded, Placebo-Controlled, Pilot Study of the Combination of Valacyclovir + Celecoxib (IMC-2) for the Treatment of Post-Acute Sequelae of SARS-CoV-2 Infectio | COMPLETED | PHASE2 | Bateman Horne Center | Valacyclovir celecoxib dose 1; Valacyclovir celecoxib dose 2; Placebo |
| NCT05668091 | An Interventional Decentralized Phase 2, Randomized, Double-Blind, 2-Arm Study to Investigate the Efficacy and Safety of Orally Administered Nirmatrelvir/Ritonavir Compared with Pl | COMPLETED | PHASE2 | Harlan M Krumholz | Nirmatrelvir; Ritonavir; Placebo |
| NCT06404099 | RECOVER-SLEEP: A Platform Protocol for Evaluation of Interventions for Sleep Disturbances in Post-Acute Sequelae of SARS-CoV-2 Infection (PASC) | COMPLETED | PHASE2 | Duke University | Modafinil; Modafinil Placebo; Solriamfetol; Solriamfetol Placebo |
| NCT04961190 | A Comparison of Prolonged Exposure Therapy, Pharmacotherapy, and Their Combination for PTSD: What Works Best, and for Whom | ACTIVE_NOT_RECRUITING | PHASE4 | University of Pennsylvania | Prolonged Exposure Therapy; Pharmacotherapy with paroxetine or venlafaxine XR |
| NCT05823896 | An Interventional, Double-Blinded, 2-Arm Study to Investigate the Efficacy of Orally Administered Nirmatrelvir/Ritonavir Compared with Placebo/Ritonavir in Non-hospitalized Adult P | COMPLETED | PHASE2 | Karolinska Institutet | Nirmatrelvir/ritonavir; Placebo/ritonavir |
| NCT05760092 | The Use of Photobiomodulation in the Treatment of Oral Complaints of Long COVID-19. A Randomized Controlled Trial. | COMPLETED | PHASE2 | University of Nove de Julho | Institutional standard treatment for xerostomia and Long Covid; Photobiomodulation Therapy; Placebo Photobiomodulation Therapy |
| NCT04842448 | Hyperbaric Oxygen for Treatment of Long COVID Syndrome; A Randomized, Placebo-Controlled, Double-Blind, Phase II Clinical Trial | COMPLETED | PHASE2 | Karolinska University Hospital | Hyperbaric oxygen; Sham treatment |
| NCT05152849 | A Randomized, Double-Blind, Placebo-Controlled Pilot Study to Evaluate the Efficacy, Safety, and Tolerability of AXA1125 in Subjects With Fatigue-Predominant Post-Acute Sequelae of | COMPLETED | PHASE2 | Axcella Health, Inc | AXA1125; Placebo |
| NCT06305806 | RECOVER-AUTONOMIC (Ivabradine): Randomized Trial of the Effect of Ivabradine Versus Placebo on Long COVID Symptoms | COMPLETED | PHASE2 | Kanecia Obie Zimmerman | Ivabradine; Ivabradine Placebo; Coordinated Care; Usual Care |
| NCT04944121 | A Phase 2, Double-blind, Placebo-controlled Study of RSLV-132 in Subjects With Post-acute COVID-19 (Long COVID) | COMPLETED | PHASE2 | Resolve Therapeutics | RSLV-132; Sodium Chloride 0.9% |
| NCT05212688 | A Randomised Phase II Study to Investigate the Effectiveness of ACUpuncture for the Relief of Long COVID Related Fatigue. | COMPLETED | PHASE2 | Royal Marsden NHS Foundation Trust | Acupuncture; Active Control |
| NCT05445674 | Plasma Exchange Therapy for Post- COVID-19 Condition: A Pilot, Randomized Double-Blind Study | COMPLETED | PHASE2 | Fundación FLS de Lucha Contra el Sida, las Enfermedades Infecciosas y la Promoción de la Salud y la Ciencia | Plasma Exchange Procedure; Sham Plasma Exchange Procedure |
| NCT07492953 | Using Enhanced External Counterpulsation to Recover Cardiovascular Function for Patient of Chronic Diseases | COMPLETED | nan | National Defense Medical Center, Taiwan | enhanced external counterpulsation |
| NCT05638620 | Evaluating the Effectiveness of Dual Sympathetic Blocks for Patients Experiencing Sympathetically-Mediated Symptoms From Post-Acute Sequelae of SARS-CoV-2 (PASC) | COMPLETED | PHASE1 | Jonathann Kuo, MD | stellate ganglion block with 0.5% bupivacaine |
| NCT06404073 | RECOVER-ENERGIZE: A Platform Protocol for Evaluation of Interventions for Exercise Intolerance in Post-Acute Sequelae of SARS-CoV-2 Infection (PASC) | COMPLETED | nan | Duke University | Structured Pacing; Usual Care |
| NCT05848401 | Biosound Therapy as a Treatment for Long COVID Patients: A Randomized Pilot Trial | COMPLETED | nan | Anxiety Relief Center | Biosound Therapy System |
| NCT05679505 | Effects of Vagus Nerve Stimulation in Post-COVID-19 Syndrome: A Randomized Controlled Trial | COMPLETED | nan | Bahçeşehir University | Auricular transcutaneous vagus nerve stimulation |
| NCT06721949 | Taurine Supplementation as a Novel Therapeutic Approach for Neurocognitive Symptoms in Long COVID | RECRUITING | PHASE2; PHASE3 | University of Alberta | Taurine; Placebo |
| ID | Title | Year | Journal | Source | Linked NCTs |
|---|---|---|---|---|---|
| PMID:32411717.0 | Intravenous Cyclophosphamide in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome. An Open-Label Phase II Study. | 2020 | Frontiers in medicine | Europe PMC; OpenAlex; PubMed | nan |
| PMID:32729939.0 | Postdischarge symptoms and rehabilitation needs in survivors of COVID-19 infection: A cross-sectional evaluation. | 2021 | Journal of medical virology | PubMed | NCT04841759 |
| PMID:32764516.0 | Autonomic Phenotypes in Chronic Fatigue Syndrome (CFS) Are Associated with Illness Severity: A Cluster Analysis. | 2020 | Journal of clinical medicine | PubMed | nan |
| PMID:32869588.0 | [Effect of ginger-separated moxibustion on fatigue, sleep quality and depression in patients with chronic fatigue syndrome: a randomized controlled trial]. | 2020 | Zhongguo zhen jiu = Chinese acupuncture & moxibustion | PubMed | nan |
| PMID:32930040.0 | Cognitive behavioural therapy for chronic fatigue and chronic fatigue syndrome: outcomes from a specialist clinic in the UK. | 2020 | Journal of the Royal Society of Medicine | PubMed | nan |
| PMID:33101925.0 | Effectiveness a herbal medicine (Sipjeondaebo-tang) on adults with chronic fatigue syndrome: A randomized, double-blind, placebo-controlled trial. | 2021 | Integrative medicine research | PubMed | nan |
| PMID:33114401.0 | Reliability and Validity of the Modified Korean Version of the Chalder Fatigue Scale (mKCFQ11). | 2020 | Healthcare (Basel, Switzerland) | PubMed | nan |
| PMID:33166287.0 | Persistent fatigue following SARS-CoV-2 infection is common and independent of severity of initial infection. | 2020 | PloS one | PubMed | nan |
| PMID:33528911.0 | Open-label study with the monoamine stabilizer (-)-OSU6162 in myalgic encephalomyelitis/chronic fatigue syndrome. | 2021 | Brain and behavior | Europe PMC; PubMed | nan |
| PMID:33562427.0 | Treatment, Persistent Symptoms, and Depression in People Infected with COVID-19 in Bangladesh. | 2021 | International journal of environmental research and public health | PubMed | nan |
| PMID:33633851.0 | Chronic fatigue syndrome (CFS)/Myalgic Encephalomyelitis (ME) and Fibromyalgia (FM): the foundation of a relationship. | 2021 | British journal of pain | PubMed | nan |
| PMID:33764478.0 | Assessment of rehabilitation needs in patients after COVID-19: Development of the COVID-19-rehabilitation needs survey. | 2021 | Journal of rehabilitation medicine | PubMed | NCT06156241 |
| PMID:33789412.0 | Characterizing the Symptoms of Patients with Persistent Post-Treatment Lyme Symptoms: A Survey of Patients at a Lyme Disease Clinic in Rhode Island. | 2021 | Rhode Island medical journal (2013) | PubMed | nan |
| PMID:33791475.0 | The impact of COVID-19 shielding on the wellbeing, mental health and treatment adherence of adults with cystic fibrosis. | 2021 | Future healthcare journal | PubMed | nan |
| PMID:33865161.0 | Decreased quality of life and spirometric alterations even after mild-moderate COVID-19. | 2021 | Respiratory medicine | PubMed | nan |
| PMID:33895431.0 | Guided graded exercise self-help for chronic fatigue syndrome: Long term follow up and cost-effectiveness following the GETSET trial. | 2021 | Journal of psychosomatic research | PubMed | nan |
| PMID:34037351.0 | [Post-COVID-19 asthenic syndrome]. | 2021 | Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova | PubMed | nan |
| PMID:34072494.0 | Tolerability and Efficacy of s.c. IgG Self-Treatment in ME/CFS Patients with IgG/IgG Subclass Deficiency: A Proof-of-Concept Study. | 2021 | Journal of clinical medicine | PubMed | nan |
| PMID:34310576.0 | Work and social functioning in frontline healthcare workers during the covid-19 pandemic in Italy: role of acute post-traumatic stress, depressive and anxiety symptoms. | 2021 | Rivista di psichiatria | PubMed | nan |
| PMID:34425627.0 | [Complaints and clinical findings six months after COVID-19: outpatient follow-up at the University Medical Center Freiburg]. | 2021 | Deutsche medizinische Wochenschrift (1946) | PubMed | nan |
| PMID:34444817.0 | Effect of Dietary Coenzyme Q10 Plus NADH Supplementation on Fatigue Perception and Health-Related Quality of Life in Individuals with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Prospective, Randomized, Double- | 2021 | Nutrients | Europe PMC; OpenAlex; PubMed | NCT05454683 |
| PMID:34498994.0 | Graded exercise therapy for patients with chronic fatigue syndrome in secondary care - a benchmarking study. | 2022 | Disability and rehabilitation | PubMed | nan |
| PMID:34564089.0 | A Randomized Controlled Trial of the Efficacy of Systemic Enzymes and Probiotics in the Resolution of Post-COVID Fatigue. | 2021 | Medicines (Basel, Switzerland) | OpenAlex; PubMed | nan |
| PMID:34582513.0 | Characterizing Post-treatment Lyme Disease Syndrome: A Mixed Methods Study of Patients at a Lyme Disease Clinic in Rhode Island. | 2021 | Rhode Island medical journal (2013) | Europe PMC; PubMed | nan |
| PMID:34604980.0 | Fatigue in post-acute sequelae of SARS-CoV2 (PASC) treated with oxygen-ozone autohemotherapy - preliminary results on 100 patients. | 2021 | European review for medical and pharmacological sciences | PubMed | nan |
| PMID:34620202.0 | The impact of Post-COVID-Syndrome on functioning - results from a community survey in patients after mild and moderate SARS-CoV-2-infections in Germany. | 2021 | Journal of occupational medicine and toxicology (London, England) | PubMed | nan |
| PMID:34626924.0 | High prevalence of post COVID-19 fatigue in patients with type 2 diabetes: A case-control study. | 2021 | Diabetes & metabolic syndrome | PubMed | nan |
| PMID:34640447.0 | Effectiveness of a Primary Care Telerehabilitation Program for Post-COVID-19 Patients: A Feasibility Study. | 2021 | Journal of clinical medicine | OpenAlex; PubMed | nan |
| PMID:34698591.0 | The effects of respiratory exercises on partial pressures of gases and anxiety in the acute phase of COVID-19 infection. | 2022 | Physiotherapy theory and practice | PubMed | nan |
| PMID:34768725.0 | Post-COVID-19 Sydrome and Decrease in Health-Related Quality of Life in Kidney Transplant Recipients after SARS-COV-2 Infection-A Cohort Longitudinal Study from the North of Poland. | 2021 | Journal of clinical medicine | PubMed | nan |
| PMID:34862223.0 | Hyperbaric oxygen therapy for the treatment of long COVID: early evaluation of a highly promising intervention. | 2021 | Clinical medicine (London, England) | PubMed | nan |
| PMID:34901100.0 | A Botanical Product Containing Cistanche and Ginkgo Extracts Potentially Improves Chronic Fatigue Syndrome Symptoms in Adults: A Randomized, Double-Blind, and Placebo-Controlled Study. | 2021 | Frontiers in nutrition | OpenAlex; PubMed | nan |
| PMID:34939506.0 | Post-Covid-19 Syndrome: Improvements in Health-Related Quality of Life Following Psychology-Led Interdisciplinary Virtual Rehabilitation. | 2021 | Journal of primary care & community health | PubMed | nan |
| PMID:34961519.0 | Prevalence of and risk factors for depressive and anxiety symptoms in a large sample of Chinese adolescents in the post-COVID-19 era. | 2021 | Child and adolescent psychiatry and mental health | PubMed | nan |
| PMID:34982039.0 | An mHealth App for Fibromyalgia-like Post-COVID-19 Syndrome: Protocol for the Analysis of User Experience and Clinical Data. | 2022 | JMIR research protocols | PubMed | nan |
| PMID:34987499.0 | Lasting Immunological Imprint of Primary Epstein-Barr Virus Infection With Associations to Chronic Low-Grade Inflammation and Fatigue. | 2021 | Frontiers in immunology | PubMed | nan |
| PMID:35011770.0 | Patients with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) Greatly Improved Fatigue Symptoms When Treated with Oxygen-Ozone Autohemotherapy. | 2021 | Journal of clinical medicine | Europe PMC; PubMed | nan |
| PMID:35011914.0 | Male vs. Female Differences in Responding to Oxygen-Ozone Autohemotherapy (O2-O3-AHT) in Patients with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS). | 2021 | Journal of clinical medicine | Europe PMC; PubMed | nan |
| PMID:35039178.0 | [Evolution and quality of life at three months after hospitalization for COVID pneumonia]. | 2022 | Rehabilitacion | PubMed | nan |
| PMID:35060361.0 | Long COVID-19: Objectifying most self-reported neurological symptoms. | 2022 | Annals of clinical and translational neurology | PubMed | nan |
| PMID:35096923.0 | Oral Bacteriotherapy Reduces the Occurrence of Chronic Fatigue in COVID-19 Patients. | 2021 | Frontiers in nutrition | PubMed | nan |
| PMID:35171410.0 | Cardiovascular Autonomic Regulation, ETCO2 and the Heart Rate Response to the Tilt Table Test in Patients with Orthostatic Intolerance. | 2022 | Applied psychophysiology and biofeedback | PubMed | nan |
| PMID:35196130.0 | Transitioning from In-Person to Telemedicine Within Primary Care Behavioral Health During COVID-19. | 2022 | Population health management | PubMed | nan |
| PMID:35256450.0 | Long COVID and episodic disability: advancing the conceptualisation, measurement and knowledge of episodic disability among people living with Long COVID - protocol for a mixed-methods study. | 2022 | BMJ open | PubMed | nan |
| PMID:35298664.0 | [Persistent fatigue symptoms following COVID-19 infection in healthcare workers: risk factors and impact on quality of life]. | 2022 | Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz | PubMed | nan |
| PMID:35359819.0 | SingStrong-A singing and breathing retraining intervention for respiratory and other common symptoms of long COVID: A pilot study. | 2022 | Canadian journal of respiratory therapy : CJRT = Revue canadienne de la therapie respiratoire : RCTR | PubMed | nan |
| PMID:35449711.0 | An online survey data in senior high school students and their parents in China during the outbreak of coronavirus disease 2019. | 2022 | Data in brief | PubMed | nan |
| PMID:35473345.0 | Ginger-indirect moxibustion plus acupuncture versus acupuncture alone for chronic fatigue syndrome: a randomized controlled trial. | 2022 | Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan | OpenAlex; PubMed | nan |
| PMID:35473737.0 | Therapies for Long COVID in non-hospitalised individuals: from symptoms, patient-reported outcomes and immunology to targeted therapies (The TLC Study). | 2022 | BMJ open | PubMed | nan |
| PMID:35487736.0 | Light acupuncture and five-element music therapy for nurses' mental health and well-being during and post-COVID-19: protocol for a randomised cross-over feasibility study. | 2022 | BMJ open | PubMed | nan |
| NCT ID | Title | Status | Phase | Sponsor | Intervention |
|---|---|---|---|---|---|
| NCT05999435 | A DOUBLE-BLIND, RANDOMIZED, PLACEBO-CONTROLLED, ADAPTIVE PHASE 2/3 STUDY OF THE EFFICACY OF LAU-7b IN THE TREATMENT OF ADULTS WITH LONG COVID AND MODERATE TO SEVERE SYMPTOMS | COMPLETED | PHASE2; PHASE3 | Laurent Pharmaceuticals Inc. | LAU-7b for 3 cycles; LAU-7b for 1 cycle, then placebo; Placebo for 3 cycles |
| NCT05074888 | A Multicenter, Double-blind, Placebo-controlled, Parallel-group, Randomized Clinical Trial of Efficacy and Safety of Prospekta in the Treatment of Patients With Post-COVID-19 Asthe | COMPLETED | PHASE3 | Materia Medica Holding | Prospekta; Placebo |
| NCT05592418 | A Randomized, Double Blind, Placebo Controlled Study to Evaluate the Efficacy and Safety of Ampligen® in Patients With Post-COVID Conditions | COMPLETED | PHASE2 | AIM ImmunoTech Inc. | Rintatolimod; Placebo / Normal Saline |
| NCT05576662 | Selective Trial Of Paxlovid for PASC (STOP-PASC): Randomized Double-Blind Placebo-Controlled Pilot Trial of Paxlovid for the Treatment of PASC | COMPLETED | PHASE2 | Stanford University | Nirmatrelvir; Placebo; Ritonavir |
| NCT05965726 | RECOVER-VITAL: A Platform Protocol for Evaluation of Interventions for Viral Persistence, Viral Reactivation, and Immune Dysregulation in Post-Acute Sequelae of SARS-CoV-2 Infectio | COMPLETED | PHASE2 | Kanecia Obie Zimmerman | Paxlovid; Ritonavir; Nirmatrelvir-matching placebo |
| NCT03674541 | The Exercise Response to Pharmacologic Cholinergic Stimulation in Myalgic Encephalomyelitis / Chronic Fatigue Syndrome | COMPLETED | PHASE2 | Brigham and Women's Hospital | Pyridostigmine Bromide; Placebo |
| NCT05877508 | An Exploratory, Randomized, Double-Blind Placebo-Controlled Study to Assess the Safety of an Anti-SARS-CoV-2 Monoclonal Antibody and Response to Treatment in Individuals With Long | ACTIVE_NOT_RECRUITING | PHASE2 | Michael Peluso, MD | AER002; Placebo |
| NCT04880161 | A Randomized, Double-Blinded, Placebo-Controlled Phase I Study to Evaluate the Safety and Efficacy of Ampion in Patients With Prolonged Respiratory Symptoms Due to COVID-19 (Long C | COMPLETED | PHASE1 | Ampio Pharmaceuticals. Inc. | Ampion; Placebo |
| NCT06161688 | Placebo-Controlled, Randomized Trial of Ensitrelvir (S-217622) for Viral Persistence and Inflammation in People Experiencing Long COVID (PREVAIL-LC) | ACTIVE_NOT_RECRUITING | PHASE2 | Timothy Henrich | Ensitrelvir; Placebo |
| NCT05205460 | Effectiveness of a 12-week Telerehabilitation Training in People With Long COVID: A Randomized Controlled Trial | COMPLETED | nan | Tri-Service General Hospital | Home-based telerehabilitation; Education and self-exercise |
| NCT05946551 | Feasibility Assessment of a Decentralized Platform Adaptive Double-Blind, Randomized Controlled Trial Investigating Repurposed Drugs in the Treatment of Post-Acute Sequelae of Coro | TERMINATED | PHASE3 | Emory University | Cetirizine; Famotidine; Cetirizine Placebo; Famotidine Placebo |
| NCT05513560 | REcovering From COVID-19 Lingering Symptoms Adaptive Integrative Medicine (RECLAIM) | COMPLETED | PHASE2; PHASE3 | University Health Network, Toronto | Ibudilast; Pentoxifylline; Placebo |
| NCT04988282 | Systemic Corticosteroids in Treatment of Post-COVID-19 Interstitial Lung Disease | COMPLETED | PHASE4 | Turkish Thoracic Society | Methylprednisolone Tablet |
| NCT05890534 | Pycnogenol® in People With Post-COVID-19 Condition: a Quadruple-blind, Randomized, Placebo-controlled Trial | COMPLETED | PHASE3 | University of Zurich | Pycnogenol®; Placebo |
| NCT06383819 | Multicenter, Randomized, Double-blind, Placebo-controlled Parallel-group Study to Evaluate the Efficacy and Safety of Longidaza® for the Treatment of Patients With Residual Changes | COMPLETED | PHASE3 | NPO Petrovax | Longidaza®; Placebo |
| NCT05619653 | Randomised Placebo Controlled Clinical Trial of Efficacy of MYOcardial Protection in Patients With Postacute inFLAMmatory Cardiac involvEment Due to COVID-19 | ACTIVE_NOT_RECRUITING | PHASE3 | Valentina Puentmann | Prednisolone; Losartan |
| NCT05618574 | Nitrite Supplementation to Mitigate Fatigability and Increase Function in Long COVID Patients | COMPLETED | PHASE2 | VA Office of Research and Development | 140 ml per day of Beet-It nitrate beverage (James White Drinks Ltd., Ipswich, UK); 210 ml of nitrate-depleted placebo |
| NCT05823896 | An Interventional, Double-Blinded, 2-Arm Study to Investigate the Efficacy of Orally Administered Nirmatrelvir/Ritonavir Compared with Placebo/Ritonavir in Non-hospitalized Adult P | COMPLETED | PHASE2 | Karolinska Institutet | Nirmatrelvir/ritonavir; Placebo/ritonavir |
| NCT05152849 | A Randomized, Double-Blind, Placebo-Controlled Pilot Study to Evaluate the Efficacy, Safety, and Tolerability of AXA1125 in Subjects With Fatigue-Predominant Post-Acute Sequelae of | COMPLETED | PHASE2 | Axcella Health, Inc | AXA1125; Placebo |
| NCT05430152 | A Double Blind Randomized Trial of Low-dose Naltrexone for Post-COVID Fatigue Syndrome | COMPLETED | PHASE2 | Luis Nacul | Low-Dose Naltrexone; Placebo |
| NCT05323331 | Effects of Circuit Training Program on Cardiopulmonary Parameters and Functional Capacity in Post COVID 19 Patients | COMPLETED | nan | Riphah International University | Circuit Training Exercise Program; Aerobic Training Exercise Program |
| NCT06840873 | Effectiveness of a 8-week Tele-Rehabilitative Exercise Training Program on Fatigue, Symptom Severity, and Quality of Life in Nurses With Long COVID: A Randomized Controlled Trial | COMPLETED | nan | Shang-Lin Chiang | wearable device; Healthy consulation |
| NCT07492953 | Using Enhanced External Counterpulsation to Recover Cardiovascular Function for Patient of Chronic Diseases | COMPLETED | nan | National Defense Medical Center, Taiwan | enhanced external counterpulsation |
| NCT05638620 | Evaluating the Effectiveness of Dual Sympathetic Blocks for Patients Experiencing Sympathetically-Mediated Symptoms From Post-Acute Sequelae of SARS-CoV-2 (PASC) | COMPLETED | PHASE1 | Jonathann Kuo, MD | stellate ganglion block with 0.5% bupivacaine |
| NCT06404073 | RECOVER-ENERGIZE: A Platform Protocol for Evaluation of Interventions for Exercise Intolerance in Post-Acute Sequelae of SARS-CoV-2 Infection (PASC) | COMPLETED | nan | Duke University | Structured Pacing; Usual Care |
| NCT05299333 | Comparison of the Effectiveness of Pulmonary Telerehabilitation and Physical Activity Recommendations in Patients With Pulmonary Fibrosis Due to COVID-19 | COMPLETED | nan | Istanbul University - Cerrahpasa | Exercise |
| NCT06721949 | Taurine Supplementation as a Novel Therapeutic Approach for Neurocognitive Symptoms in Long COVID | RECRUITING | PHASE2; PHASE3 | University of Alberta | Taurine; Placebo |
| NCT05119634 | The Effect of Whole Body Vibration Training in Individuals With Post COVID - 19 | COMPLETED | nan | Istanbul University - Cerrahpasa | whole body vibration training; home based exercises |
| NCT05107440 | BREATHE: A Mixed-methods Evaluation of a Virtual Self-management Program for People Living With Long COVID-19 in Alberta | COMPLETED | nan | University of Calgary | BREATHE |
| NCT05218174 | Exercise Training and Functional, Cognitive, and Emotional Well-being in Adults with Post-Acute Sequelae of SARS-CoV-2 (COVID-19) Infection (PASC): a Randomized Controlled Trial | COMPLETED | nan | Baylor Research Institute | Exercise Prescription |
| NCT05216549 | Water and Land-based Exercise for Children With Post COVID-19 Condition | COMPLETED | nan | Józef Piłsudski University of Physical Education | Water-based exercise; Land-based exercise |
| NCT05840237 | REGAIN: A Randomized, Double Blind, Placebo Controlled Trial to Determine the Effects of Oxaloacetate on Improving Fatigue in Long COVID | COMPLETED | nan | Terra Biological LLC | Anhydrous Enol-Oxaloacetate, a "Medical Food"; White Rice Flour |
| NCT06330376 | Diaphragmatic Breathing Exercises for Post-COVID-19 Diaphragmatic Dysfunction (DD) | COMPLETED | nan | University of Minnesota | Usual care of traditional treatment; Specific DB program/Diaphragmatic manipulation program |
| NCT06952127 | Pilot Study Evaluating the Feasibility and Appropriateness of a Telerehabilitation Exercise Program in People With Post-COVID-19 Sequelae: a Single-center Randomized Trial. | COMPLETED | nan | Centre intégré universitaire de santé et de services sociaux de la Mauricie-et-du-Centre-du-Québec | Rehabilitation program |
| NCT05866224 | Effects of a Telerehabilitation Program and Detraining on Cardiorespiratory Fitness in Patients With Post-COVID-19 Sequelae | COMPLETED | nan | Campus docent Sant Joan de Déu-Universitat de Barcelona | Telerehabilitation program |
| NCT05973136 | A Pilot Study to Evaluate the Implantation and the Impact of a Hybrid Telerehabilitation Program Based on Cardiopulmonary Rehabilitation Principles for People With Post-COVID Affec | COMPLETED | nan | Université de Sherbrooke | Telerehabilitation program based on cardiorespiratory principles |
| NCT06535165 | Effect of 14-day Red Beetroot Juice Intake on Physical Function, Gut Microbiota Composition, and Systemic Inflammation in Adults With Long COVID-19 | COMPLETED | nan | Catholic University of the Sacred Heart | Red Beetroot Juice; Placebo |
| NCT05710770 | Double-blinded, Randomized, Sham-controlled Trial of Immunoadsorption (IA) in Patients With Chronic Fatigue Syndrome (CFS) Including Patients With Post-acute COVID-19 CFS (PACS-CFS | COMPLETED | nan | Charite University, Berlin, Germany | Immunoadsorption |
| NCT06165835 | Study on Post-Acute COVID-19 Syndrome in Improvement of COVID-19 Rehabilitated Patients by Respiratory Training | COMPLETED | nan | Tri-Service General Hospital | breathing training |
| NCT06004310 | Effect of Pulmonary Rehabilitation Among Post-COVID-19 Patients in a Tertiary Care Hospital in Bangladesh: A Quasi-Experimental Study | COMPLETED | nan | Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh | Pulmonary Rehabilitation |
| NCT05244044 | Changes in Functional Exercise Capacity After PUlmonary REhabilitation in Primary Care: a Randomized, Controlled, Multicenter, Pragmatic Trial in 134 Patients With Long COVID (PuRe | COMPLETED | nan | University Hospital, Antwerp | Pulmonary rehabilitation in primary care |
| NCT07280572 | RECLAIM: an Adaptive Platform Trial for the Evaluation of Treatments for Post-Acute Sequelae of SARS-CoV-2 Infection (PASC) | ENROLLING_BY_INVITATION | PHASE3 | Janneke van de Wijgert | Metformin; colchicine |
| NCT07508332 | Lung Boost Trainer Versus Incentive Spirometer on Spiro-metric Indices in Post COVID-19 Hemiplegic Cerebral Palsy Children; Randomized Controlled Trial | COMPLETED | nan | Cairo University | Lung boost trainer (LBT); Incentive Spirometer Training ( IST); Traditional Respiratory Physical Therapy Protocol (TRPT) |
| NCT06814379 | Rehabilitation of Fatigue in Patients With Post-COVID-19 Syndrome | COMPLETED | nan | Universidad de Granada | Rehabilitation; Virtual reality based rehabilitation |
| NCT07184398 | Use of a Cysteine-rich Whey Protein Isolate (Immunocal®) in Post COVID-19 Cognitive Impairment | COMPLETED | nan | Universidad Libre seccional Cali | Intervention with Consolidated Cysteine (Immunocal) 20 g per day; Cognitive rehabilitation workshops |
| NCT05373407 | A Randomized Controlled Trial Examining the Impact of Low Versus Moderate-intensity Aerobic Training in Post-discharge COVID-19 Older Subjects | COMPLETED | nan | University of Hail | aerobic exercise |
| NCT05699538 | Fatigue and Fatigability in Veterans Following SARS-CoV-2 Infection | COMPLETED | nan | VA Office of Research and Development | Minimal-Dose Home-Based Resistance Exercise |
| NCT05282199 | Efficacy of Inspiratory Muscle Training (IMT) on Sleep Quality, Exercise Tolerance and Pulmonary Radioaerosol Deposition Pattern in Post COVID-19 Infection Subjects | COMPLETED | nan | Universidade Federal de Pernambuco | INSPIRATORY MUSCLE TRAINING |
| NCT04841759 | The Effects of a Multi-factorial Rehabilitation Program for Healthcare Workers Suffering From Post-COVID-19 Fatigue Syndrome | COMPLETED | nan | Medical University of Vienna | Exercise |
| NCT05848518 | Effect of Different Types of Supervised Exercise Programs on Cardiorespiratory and Muscular Fitness, Pain, Fatigue, Mental Health and Inflammatory and Oxidative Stress Biomarkers i | COMPLETED | nan | Campus docent Sant Joan de Déu-Universitat de Barcelona | Rehabilitation program |
| ID | Title | Year | Journal | Source | Linked NCTs |
|---|---|---|---|---|---|
| PMID:31884303.0 | Post-exertional malaise is associated with greater symptom burden and psychological distress in patients diagnosed with Chronic Fatigue Syndrome. | 2020 | Journal of psychosomatic research | PubMed | nan |
| PMID:32431134.0 | How the COVID-19 infection tsunami revolutionized the work of respiratory physiotherapists: an experience from Northern Italy. | 2020 | Monaldi archives for chest disease = Archivio Monaldi per le malattie del torace | PubMed | nan |
| PMID:32568143.0 | Post-exertional symptoms distinguish Myalgic Encephalomyelitis/Chronic Fatigue Syndrome subjects from healthy controls. | 2020 | Work (Reading, Mass.) | OpenAlex; PubMed | nan |
| PMID:33119613.0 | Effect of disease duration in a randomized Phase III trial of rintatolimod, an immune modulator for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome. | 2020 | PloS one | Europe PMC; PubMed | nan |
| PMID:33184353.0 | Profile of circulating microRNAs in myalgic encephalomyelitis and their relation to symptom severity, and disease pathophysiology. | 2020 | Scientific reports | PubMed | nan |
| PMID:33247653.0 | Beyond COVID-19: Evidence-Based Consensus Statement on the Role of Physiotherapy in Pulmonary Rehabilitation in the Indian Context. | 2020 | The Journal of the Association of Physicians of India | PubMed | nan |
| PMID:33274349.0 | Informatics Inference of Exercise-Induced Modulation of Brain Pathways Based on Cerebrospinal Fluid Micro-RNAs in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome. | 2020 | Network and systems medicine | PubMed | nan |
| PMID:33331718.0 | [Exercise capacity after mechanical ventilation because of COVID-19: Cardiopulmonary exercise tests in clinical rehabilitation]. | 2020 | Nederlands tijdschrift voor geneeskunde | PubMed | nan |
| PMID:33536937.0 | Hyperventilation: A Possible Explanation for Long-Lasting Exercise Intolerance in Mild COVID-19 Survivors? | 2020 | Frontiers in physiology | PubMed | nan |
| PMID:33642858.0 | Pulmonary Rehabilitation in a Post-COVID-19 World: Telerehabilitation as a New Standard in Patients with COPD. | 2021 | International journal of chronic obstructive pulmonary disease | PubMed | nan |
| PMID:33645261.0 | Use of sit-to-stand test to assess the physical capacity and exertional desaturation in patients post COVID-19. | 2021 | Chronic respiratory disease | PubMed | nan |
| PMID:33792518.0 | Dyspnea in Chronic Low Ventricular Preload States. | 2021 | Annals of the American Thoracic Society | PubMed | nan |
| PMID:33829023.0 | Reduced Endothelial Function in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome-Results From Open-Label Cyclophosphamide Intervention Study. | 2021 | Frontiers in medicine | Europe PMC; OpenAlex; PubMed | nan |
| PMID:34080125.0 | Extrapulmonary features of post-COVID-19 patients: muscle function, physical activity, mood, and sleep quality. | 2022 | Irish journal of medical science | PubMed | nan |
| PMID:34140706.0 | Post-COVID-19 rehabilitation - a Polish pilot program. | 2021 | Medycyna pracy | PubMed | nan |
| PMID:34237048.0 | Outcomes Among Patients Referred to Outpatient Rehabilitation Clinics After COVID-19 diagnosis - United States, January 2020-March 2021. | 2021 | MMWR. Morbidity and mortality weekly report | PubMed | nan |
| PMID:34368926.0 | Exploring Symptom Fluctuations and Triggers in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Using Novel Patient-Centred N-of-1 Observational Designs: A Protocol for a Feasibility and Acceptability Study. | 2022 | The patient | Europe PMC; PubMed | nan |
| PMID:34481432.0 | [Correction of mitochondrial dysfunction in the complex rehabilitation of COVID-19]. | 2021 | Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova | PubMed | nan |
| PMID:34551948.0 | Adjunctive inspiratory muscle training for patients with COVID-19 (COVIDIMT): protocol for randomised controlled double-blind trial. | 2021 | BMJ open | PubMed | nan |
| PMID:34640447.0 | Effectiveness of a Primary Care Telerehabilitation Program for Post-COVID-19 Patients: A Feasibility Study. | 2021 | Journal of clinical medicine | OpenAlex; PubMed | nan |
| PMID:34664483.0 | Do not forget the lungs: preliminary feasibility study on I/E mode physiotherapy for people recovering from COVID-19. | 2022 | Panminerva medica | PubMed | nan |
| PMID:34682970.0 | A Comprehensive Examination of Severely Ill ME/CFS Patients. | 2021 | Healthcare (Basel, Switzerland) | Europe PMC; PubMed | nan |
| PMID:34689061.0 | Respiratory rehabilitation for Covid-19 related persistent dyspnoea: A one-year experience. | 2021 | Respiratory medicine | PubMed | nan |
| PMID:34698591.0 | The effects of respiratory exercises on partial pressures of gases and anxiety in the acute phase of COVID-19 infection. | 2022 | Physiotherapy theory and practice | PubMed | nan |
| PMID:34718282.0 | Overview of Symptoms of Ongoing Symptomatic and Post-COVID-19 Patients Who Were Reffered to Pulmonary Rehabilitation - First Single-Centre Experience in Croatia. | 2021 | Psychiatria Danubina | PubMed | nan |
| PMID:34821709.0 | Post-Acute Sequelae of COVID-19 and Cardiovascular Autonomic Dysfunction: What Do We Know? | 2021 | Journal of cardiovascular development and disease | Europe PMC; PubMed | NCT05566379 |
| PMID:34827194.0 | Subclinical Myocardial Dysfunction in Patients Recovered from COVID-19 Disease: Correlation with Exercise Capacity. | 2021 | Biology | PubMed | nan |
| PMID:34901100.0 | A Botanical Product Containing Cistanche and Ginkgo Extracts Potentially Improves Chronic Fatigue Syndrome Symptoms in Adults: A Randomized, Double-Blind, and Placebo-Controlled Study. | 2021 | Frontiers in nutrition | OpenAlex; PubMed | nan |
| PMID:34945095.0 | Long COVID a New Derivative in the Chaos of SARS-CoV-2 Infection: The Emergent Pandemic? | 2021 | Journal of clinical medicine | PubMed | nan |
| PMID:35019775.0 | From heart to muscle: pathophysiological mechanisms underlying long-term physical sequelae from SARS-CoV-2 infection. | 2022 | Journal of applied physiology (Bethesda, Md. : 1985) | PubMed | nan |
| PMID:35055495.0 | Physical Fitness Differences, Amenable to Hypoxia-Driven and Sarcopenia Pathophysiology, between Sleep Apnea and COVID-19. | 2022 | International journal of environmental research and public health | PubMed | nan |
| PMID:35160223.0 | Pain Burden in Post-COVID-19 Syndrome following Mild COVID-19 Infection. | 2022 | Journal of clinical medicine | PubMed | nan |
| PMID:35232954.0 | [Post-covid syndrome after icu admission. Parameters related to a better physical recovery after 4 months.]. | 2022 | Revista espanola de salud publica | PubMed | nan |
| PMID:35272262.0 | The effectiveness of pulmonary rehabilitation for Post-COVID symptoms: A rapid review of the literature. | 2022 | Respiratory medicine | PubMed | nan |
| PMID:35287333.0 | Long-Term COVID 19 Sequelae in Adolescents: the Overlap with Orthostatic Intolerance and ME/CFS. | 2022 | Current pediatrics reports | Europe PMC; PubMed | nan |
| PMID:35291305.0 | Swimming Exercise for Patients With Long-Term Respiratory Post COVID-19 Complications: Further Thinking on the Pulmonary Rehabilitation. | 2022 | Archivos de bronconeumologia | PubMed | nan |
| PMID:35364291.0 | Cardiorespiratory physiology, exertional symptoms, and psychological burden in post-COVID-19 fatigue. | 2022 | Respiratory physiology & neurobiology | PubMed | nan |
| PMID:35418075.0 | Establishing a Post-Acute Covid-19 AHP Led Rehabilitation Clinic. | 2022 | Irish medical journal | PubMed | nan |
| PMID:35421511.0 | The underlying sex differences in neuroendocrine adaptations relevant to Myalgic Encephalomyelitis Chronic Fatigue Syndrome. | 2022 | Frontiers in neuroendocrinology | Europe PMC; PubMed | nan |
| PMID:35433768.0 | Diagnosis of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome With Partial Least Squares Discriminant Analysis: Relevance of Blood Extracellular Vesicles. | 2022 | Frontiers in medicine | Europe PMC; PubMed | nan |
| PMID:35464473.0 | Persistent Lung Injury and Prothrombotic State in Long COVID. | 2022 | Frontiers in immunology | PubMed | nan |
| PMID:35473371.0 | Impact of surgical mask on performance and cardiorespiratory responses to submaximal exercise in COVID-19 patients near hospital discharge: A randomized crossover trial. | 2022 | Clinical rehabilitation | PubMed | nan |
| PMID:35526605.0 | Neurovascular Dysregulation and Acute Exercise Intolerance in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Randomized, Placebo-Controlled Trial of Pyridostigmine. | 2022 | Chest | Europe PMC; PubMed | NCT03674541; NCT07454395 |
| PMID:35535102.0 | Fatigue in Cirrhosis. | 2022 | Journal of clinical and experimental hepatology | PubMed | nan |
| PMID:35543533.0 | Impaired exercise capacity in post-COVID-19 syndrome: the role of VWF-ADAMTS13 axis. | 2022 | Blood advances | PubMed | nan |
| PMID:35589660.0 | [Patients with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) Who Have Already Visited Some Medical Institutions: Diagnosis, Treatment and Research]. | 2022 | Brain and nerve = Shinkei kenkyu no shinpo | Europe PMC; PubMed | nan |
| PMID:35608204.0 | The effect of medium-term recovery status after COVID-19 illness on cardiopulmonary exercise capacity in a physically active adult population. | 2022 | Journal of applied physiology (Bethesda, Md. : 1985) | PubMed | nan |
| PMID:35616253.0 | Provision of pulmonary rehabilitation in Latin America 18 months after the COVID-19 pandemic: A survey of the Latin American Thoracic Association. | 2022 | Chronic respiratory disease | PubMed | nan |
| PMID:35649438.0 | The Effects of Exercise Therapy Moderated by Sex in Rehabilitation of COVID-19. | 2022 | International journal of sports medicine | PubMed | nan |
| PMID:35775163.0 | Long-term pulmonary sequelae in adolescents post-SARS-CoV-2 infection. | 2022 | Pediatric pulmonology | PubMed | nan |
Cross-tabulation: how many records mention both a given condition family and a given readout type. This is the view that says which measurement strategies are actually being applied to which patient populations. Empty cells flag concrete gaps to address in the next search iteration.
| NCT ID | Title | Status | Phase | Sponsor | Intervention |
|---|---|---|---|---|---|
| NCT05576662 | Selective Trial Of Paxlovid for PASC (STOP-PASC): Randomized Double-Blind Placebo-Controlled Pilot Trial of Paxlovid for the Treatment of PASC | COMPLETED | PHASE2 | Stanford University | Nirmatrelvir; Placebo; Ritonavir |
| NCT05199233 | The Benefit of Mindfulness-Based Intervention Using A Wearable Wellness Brain Sensing Device (Muse-S™) in the Treatment of Post-Covid Symptoms | COMPLETED | nan | Mayo Clinic | Muse S™ Headband system |
| NCT05205460 | Effectiveness of a 12-week Telerehabilitation Training in People With Long COVID: A Randomized Controlled Trial | COMPLETED | nan | Tri-Service General Hospital | Home-based telerehabilitation; Education and self-exercise |
| NCT05597722 | Randomized Study to Evaluate Strategies to Address Cognitive Fog in Long-COVID-19 Patients | TERMINATED | PHASE4 | Eva Szigethy | Digital cognitive behavioral intervention-RxWell; Amphetamine-Dextroamphetamine |
| NCT06404112 | RECOVER-SLEEP: A Platform Protocol for Evaluation of Interventions for Sleep Disturbances in Post-Acute Sequelae of SARS-CoV-2 Infection (PASC) | COMPLETED | PHASE2 | Duke University | Melatonin; Melantonin Placebo; Tailored lighting (TL) Active; Tailored lighting (TL) Placebo |
| NCT04997395 | Safety and Tolerability of Full Spectrum Cannabidiol Dominant Medicinal Cannabis in Treating Symptoms Associated With Long COVID: A Feasibility Study | COMPLETED | PHASE2 | Bod Australia | MediCabilis Cannabis sativa 50 |
| NCT05228899 | A Phase I/II Multicenter, Randomized, Double Blinded, Placebo Trial to Evaluate the Safety and Potential Efficacy of Zofin Infused Intravenous (IV) in Patients Experiencing Prolong | COMPLETED | PHASE1; PHASE2 | ZEO ScientifiX, Inc. | Zofin; Placebo |
| NCT06840873 | Effectiveness of a 8-week Tele-Rehabilitative Exercise Training Program on Fatigue, Symptom Severity, and Quality of Life in Nurses With Long COVID: A Randomized Controlled Trial | COMPLETED | nan | Shang-Lin Chiang | wearable device; Healthy consulation |
| NCT06404073 | RECOVER-ENERGIZE: A Platform Protocol for Evaluation of Interventions for Exercise Intolerance in Post-Acute Sequelae of SARS-CoV-2 Infection (PASC) | COMPLETED | nan | Duke University | Structured Pacing; Usual Care |
| NCT05848401 | Biosound Therapy as a Treatment for Long COVID Patients: A Randomized Pilot Trial | COMPLETED | nan | Anxiety Relief Center | Biosound Therapy System |
| NCT05679505 | Effects of Vagus Nerve Stimulation in Post-COVID-19 Syndrome: A Randomized Controlled Trial | COMPLETED | nan | Bahçeşehir University | Auricular transcutaneous vagus nerve stimulation |
| NCT05218174 | Exercise Training and Functional, Cognitive, and Emotional Well-being in Adults with Post-Acute Sequelae of SARS-CoV-2 (COVID-19) Infection (PASC): a Randomized Controlled Trial | COMPLETED | nan | Baylor Research Institute | Exercise Prescription |
| NCT05973136 | A Pilot Study to Evaluate the Implantation and the Impact of a Hybrid Telerehabilitation Program Based on Cardiopulmonary Rehabilitation Principles for People With Post-COVID Affec | COMPLETED | nan | Université de Sherbrooke | Telerehabilitation program based on cardiorespiratory principles |
| NCT05389592 | Treatment of COVID-19 Post-acute Cognitive Impairment Sequelae (PASC) With Portable Brain Stimulation: a Double-blind, Randomized-controlled Trial | COMPLETED | nan | University of Sao Paulo | Active tDCS and cognitive training; Sham tDCS and cognitive training |
| NCT05282199 | Efficacy of Inspiratory Muscle Training (IMT) on Sleep Quality, Exercise Tolerance and Pulmonary Radioaerosol Deposition Pattern in Post COVID-19 Infection Subjects | COMPLETED | nan | Universidade Federal de Pernambuco | INSPIRATORY MUSCLE TRAINING |
| NCT07190105 | Impact of Vagal Approaches on Symptomatology in Long COVID Participants | COMPLETED | nan | Leidos Life Sciences | Sonocea Sonic Augmentation Technology (SAT); Truvaga Electrical Vagus Nerve Stimulator |
| NCT05648123 | Effectiveness of Supportive Psychotherapy Through Internet-Based Teleconsultation on Psychological and Somatic Symptoms, Neutrophil-Lymphocyte Ratio, and Heart Rate Variability in | COMPLETED | nan | Indonesia University | Supportive Psychotherapy |
| NCT06305793 | RECOVER-AUTONOMIC (IVIG): Randomized Trial of the Effect of IVIG Versus Placebo on Long COVID Symptoms | ACTIVE_NOT_RECRUITING | PHASE2 | Kanecia Obie Zimmerman | IVIG (intravenous immunoglobulin); IVIG Placebo; Coordinated Care; Usual Care |
| NCT05793736 | A Feasibility Study of an HVR Protocol Biofeedback Training to Manage Long Covid Syndrome Symptoms | COMPLETED | nan | University of Cagliari | Biofeedback training; Treatment as usual |
| NCT05631171 | COVIDAI: Feasibility Study of Adhera® Fatigue Digital Program for Patients With Long COVID-related Fatigue | COMPLETED | nan | Adhera Health, Inc. | Adhera® Fatigue Digital Program |
| NCT05922865 | Tri-service General Hospital, National Defence Medical Center, Taipei, Taiwan | COMPLETED | nan | Shang-Lin Chiang | KNEESUP smart knee assistive device + KNEESUP care APP; Healthy consulation |
| NCT05003271 | Pulmonary Rehabilitation Post-COVID-19: a Pilot Study | COMPLETED | nan | University of Manitoba | Exercise program (virtual/remote) |
| NCT05001542 | Could Digital Interventions Help Understand And "Flatten The Curve" Of Distress Due To Moral Injury Among Health Care Workers During The COVID Pandemic? | COMPLETED | nan | Unity Health Toronto | Educational moral injury video |
| NCT04794036 | Efficacy of an Asynchronous Telerehabilitation Programme in Post-COVID-19 Patients: a Feasibility Study | COMPLETED | nan | Universidad San Jorge | Asynchronous telerehabilitation programme; Rehabilitation programme |
| NCT05507190 | Self-management of Post COVID-19 Syndrome Using Wearable Biometric Technology | COMPLETED | nan | University of Manitoba | Self-management of post COVID-19 respiratory outcomes |
| NCT05483829 | AIDA - A Digital Health Intervention Based on Artificial Intelligence to Support the Personalized Recovery of Long COVID Patients: Feasibility Study. | COMPLETED | nan | Adhera Health, Inc. | Adhera® Fatigue for Long COVID program |
| NCT05172206 | Symptom-based Rehabilitation Compared to Usual Care in Post-COVID - a Randomized Controlled Trial | COMPLETED | nan | Schön Klinik Berchtesgadener Land | symptom-focused rehabilitation; usual care |
| NCT06189066 | Long COVID Ultrasound Trial [LOCUS Trial] | COMPLETED | nan | SecondWave Systems Inc. | Splenic Ultrasound |
| NCT05204511 | Exercise and Post-COVID/Long-COVID: Effects of Different Training Modalities on Physical Performance, Heart Rate Variability, Inflammation, Health-Related Quality of Life, Cognitiv | COMPLETED | nan | University of Vienna | endurance training; concurrent training |
| NCT05225220 | Multimodal Investigation of Post COVID-19 in Females: A Pilot Study | COMPLETED | nan | Casa Colina Hospital and Centers for Healthcare | Parasym Device (of Parasym Ltd, UK) using Transcutaneous Vagus Nerve Stimulation (t-VNS) |
| NCT06601920 | A Study of Activity Leader to Forest Therapy Campaign in Different Environments Targets on the Participants Which Had Been Infected by SARS-COV-2 | COMPLETED | nan | Taipei City Hospital | Forest healing activities |
| NCT06296914 | Developing and Testing a Mobile Health System for Patients with Postural Orthostatic Tachycardia Syndrome (POTS) | COMPLETED | nan | Jami Warren | POTSapp; Waitlist Control |
| NCT06404060 | RECOVER-ENERGIZE: A Platform Protocol for Evaluation of Interventions for Exercise Intolerance in Post-Acute Sequelae of SARS-CoV-2 Infection (PASC) | ACTIVE_NOT_RECRUITING | nan | Duke University | Personalized Cardiopulmonary Rehabilitation; Education |
| NCT06978582 | Effectiveness and Safety of a Tele-rehabilitation Program Based on Mindful and Conscious Movement-based Exercise vs Conventional Low-intensity Exercise on Fatigue and Related Varia | ACTIVE_NOT_RECRUITING | nan | University of Seville | Mindful and conscious movement-based exercise; Conventional exercise |
| NCT06968104 | Stimulation of the Transcutaneous Auricular Vagus Nerve for Improvement of Symptoms in Patients With Post-COVID Syndrome and ME/CFS | ACTIVE_NOT_RECRUITING | nan | University of Luxembourg | transcutaneous vagus nerve stimulation; transcutaneous vagus nerve stimulation |
| NCT06366724 | LIFT: Life Improvement Trial | RECRUITING | PHASE2 | Brigham and Women's Hospital | Pyridostigmine; Low-Dose Naltrexone; Placebo |
| NCT04935307 | Central Processing of Odour Stimuli in Patients With Multi-systemic Functional Somatic Disorder, Multiple Chemical Sensitivityor Post Covid Compared to Healthy Controls - the Pilot | ACTIVE_NOT_RECRUITING | nan | University of Aarhus | MRI and paraclinical tests |
| NCT05445830 | Physiological Characterization of Functional Limitations and Exercise Intolerance in Post-COVID Patients | ACTIVE_NOT_RECRUITING | nan | Karolinska Institutet | High-Intensity-Interval-Exercise; Moderate-Intensity-Continuous-Exercise; Strength training; Baseline assessment; 1 year follow-up |
| NCT06168006 | Effects of a Physical Training Program Using a Mobile App on the Functionality and Cardiovascular Function of Individuals With Post-covid-19 Syndrome: Randomized Clinical Trial | RECRUITING | nan | University of Nove de Julho | Exercise; Control |
| NCT06967428 | Effectiveness of Metabolic Modulation in Treating Post-vaccination Syndrome: A Prospective Study | NOT_YET_RECRUITING | PHASE2 | Independent Medical Alliance | Combined metabolic modulator; Rice Protein Powder with Vitamin C |
| NCT06879925 | The Effects of Qi-gong on Physiology and Quality of Life in Patients with Post-acute Sequelae of Covid-19 | RECRUITING | nan | POCHIWU | QI-GONG and control |
| NCT06822179 | Effectiveness of a Personalized In-home Telerehabilitation Program on Self-Care in Patients with Long COVID: a Randomized Clinical Trial | NOT_YET_RECRUITING | PHASE2 | CEU San Pablo University | Education for self-management; Personalised exercise program; Usual Care |
| NCT06614309 | Pilot Study to Investigate Possible Non-invasive Treatment for Long COVID (Post COVID-19 Condition) Brain Fog | RECRUITING | nan | Mayo Clinic | Acute Placebo Visit; Acute Progressive Carbon Dioxide; Acute Intermittent Hypoxia; Training: Progressive Carbon Dioxide Ramping; Training: Intermittent Hypoxic |
| NCT06248151 | Acute Cardiovascular Responses to a Single Exercise Session in Patients With Post-Covid-19 Syndrome | RECRUITING | nan | University of Nove de Julho | Exercise session; Control session |
| NCT07278206 | Mitigating Cognitive Problems and Fatigue With Brain Stimulation in Long COVID | RECRUITING | nan | Amsterdam UMC, location VUmc | Repetitive Transcranial Magnetic Stimulation; Sham device |
| NCT07110714 | Effects of Kneipp Hydrotherapy in Post-COVID-19 Patients: A Randomized Controlled Trial | RECRUITING | nan | Eggensberger OHG | Cold water hydrotherapy |
| NCT05851859 | Randomized Controlled Trial Evaluating the Effectiveness of a Breathing Control Technique on Long COVID Symptoms at the Reunion University Hospital | RECRUITING | nan | Centre Hospitalier Universitaire de la Réunion | Cardiac coherence |
| NCT06689345 | Effects of Non-invasive Neuromodulation on Post-COVID-19 Syndrome: Multicenter Study | ENROLLING_BY_INVITATION | nan | Federal University of ABC | taVNS - transauricular vagal nerve stimulation; rPMS - repetitive peripheric magnetic stimulation; rTMS - repetitive transcranial magnetic stimulation; taVNS sh |
| NCT05741112 | The Long COVID-19 Wearable Device Study | RECRUITING | nan | Scripps Translational Science Institute | Wearable device |
| NCT07013903 | Effects of Kneipp Hydrotherapy During Inpatient Post-Covid-19 Rehabilitation: A Randomized Controlled Trial | RECRUITING | nan | Schön Klinik Berchtesgadener Land | Standard rehabilitation plus cold water hydrotherapy; Standard rehabilitation only |
| ID | Title | Year | Journal | Source | Linked NCTs |
|---|---|---|---|---|---|
| PMID:33103132.0 | Interference between rhinovirus and influenza A virus: a clinical data analysis and experimental infection study. | 2020 | The Lancet. Microbe | PubMed | nan |
| PMID:33425945.0 | Obstacles and Considerations Related to Clinical Trial Research During the COVID-19 Pandemic. | 2020 | Frontiers in medicine | PubMed | nan |
| PMID:33918854.0 | Evaluation of E-Health Applications for Paediatric Patients with Refractory Epilepsy and Maintained on Ketogenic Diet. | 2021 | Nutrients | PubMed | nan |
| PMID:34178579.0 | A new privacy framework for the management of chronic diseases via mHealth in a post-Covid-19 world. | 2022 | Zeitschrift fur Gesundheitswissenschaften = Journal of public health | PubMed | nan |
| PMID:34179343.0 | Trending Technology of Glucose Monitoring during COVID-19 Pandemic: Challenges in Personalized Healthcare. | 2021 | Advanced materials technologies | PubMed | nan |
| PMID:34481597.0 | Increased Utilization of Virtual Visits and Electronic Approaches in Clinical Research During the COVID-19 Pandemic and Thereafter. | 2021 | Mayo Clinic proceedings | PubMed | nan |
| PMID:34665645.0 | Can Remote Patient Monitoring Be the New Standard in Primary Care of Chronic Diseases, Post-COVID-19? | 2022 | Telemedicine journal and e-health : the official journal of the American Telemedicine Association | PubMed | nan |
| PMID:34957011.0 | Changes in Quality of Life and Loneliness Among Middle-Aged and Older Adults Participating in Therapist-Guided Digital Mental Health Intervention. | 2021 | Frontiers in public health | PubMed | nan |
| PMID:34982039.0 | An mHealth App for Fibromyalgia-like Post-COVID-19 Syndrome: Protocol for the Analysis of User Experience and Clinical Data. | 2022 | JMIR research protocols | PubMed | nan |
| PMID:35326943.0 | The Effect of Telemonitoring (TM) on Improving Adherence with Continuous Positive Airway Pressure (CPAP) in Obstructive Sleep Apnoea (OSA): A Service Improvement Project (SIP). | 2022 | Healthcare (Basel, Switzerland) | PubMed | nan |
| PMID:35360739.0 | Applications of Artificial Intelligence in Myopia: Current and Future Directions. | 2022 | Frontiers in medicine | PubMed | nan |
| PMID:35473737.0 | Therapies for Long COVID in non-hospitalised individuals: from symptoms, patient-reported outcomes and immunology to targeted therapies (The TLC Study). | 2022 | BMJ open | PubMed | nan |
| PMID:35506018.0 | Exploring the Impact and Acceptance of Wearable Sensor Technology for Pre- and Postoperative Rehabilitation in Knee Replacement Patients: A U.K.-Based Pilot Study. | 2022 | JB & JS open access | PubMed | nan |
| PMID:35632776.0 | Impaired Vagal Activity in Long-COVID-19 Patients. | 2022 | Viruses | PubMed | nan |
| PMID:35711362.0 | Repostioning of Telemedicine in Cardiovascular World Post-COVID-19 Pandemic. | 2022 | Frontiers in cardiovascular medicine | PubMed | nan |
| PMID:36002874.0 | A pilot randomized controlled trial of supervised, at-home, self-administered transcutaneous auricular vagus nerve stimulation (taVNS) to manage long COVID symptoms. | 2022 | Bioelectronic medicine | OpenAlex; PubMed | nan |
| PMID:35787520.0 | Equity and Accessibility of Washington State's COVID-19 Digital Exposure Notification Tool (WA Notify): Survey and Listening Sessions Among Community Leaders. | 2022 | JMIR formative research | PubMed | nan |
| PMID:35960595.0 | A Digital Mental Health Intervention (Inuka) for Common Mental Health Disorders in Zimbabwean Adults in Response to the COVID-19 Pandemic: Feasibility and Acceptability Pilot Study. | 2022 | JMIR mental health | OpenAlex; PubMed | nan |
| PMID:36090762.0 | Strategies for Cardio-Oncology Care During the COVID-19 Pandemic. | 2022 | Current treatment options in cardiovascular medicine | PubMed | nan |
| PMID:36227021.0 | Smart healthcare: A prospective future medical approach for COVID-19. | 2023 | Journal of the Chinese Medical Association : JCMA | PubMed | nan |
| PMID:36298551.0 | Dysautonomia in Children with Post-Acute Sequelae of Coronavirus 2019 Disease and/or Vaccination. | 2022 | Vaccines | Europe PMC; PubMed | nan |
| PMID:36410797.0 | HEART rate variability biofeedback for long COVID symptoms (HEARTLOC): protocol for a feasibility study. | 2022 | BMJ open | Europe PMC; Preprint (medRxiv/bioRxiv); PubMed | NCT05228665 |
| PMID:36412474.0 | Impact of early pulmonary rehabilitation in postacute COVID Disease: A single-center experience from India - A quasi-experimental study. | 2022 | Indian journal of public health | PubMed | nan |
| PMID:36716162.0 | Using telemedicine interventions during COVID-19 to expand care post COVID-19. | 2023 | The American journal of managed care | PubMed | nan |
| PMID:36779003.0 | Impact of COVID-19 Pandemic on Physical Activity, Pain, Mood, and Sleep in Adults with Knee Osteoarthritis. | 2022 | Journal for the measurement of physical behaviour | PubMed | nan |
| PMID:36832445.0 | Therapeutic Approaches to Dysautonomia in Childhood, with a Special Focus on Long COVID. | 2023 | Children (Basel, Switzerland) | Europe PMC; OpenAlex; PubMed | nan |
| PMID:36923369.0 | Can digital health apps provide patients with support to promote structured diabetes education and ongoing self-management? A real-world evaluation of myDiabetes usage. | 2023 | Digital health | PubMed | nan |
| PMID:37020492.0 | A descriptive study of the clinical impacts on COVID-19 survivors using telemonitoring (The TeleCOVID Study). | 2023 | Frontiers in medical technology | PubMed | nan |
| PMID:37194742.0 | Incidence of ventricular arrhythmias related to COVID infection and vaccination in patients with Brugada syndrome: Insights from a large Italian multicenter registry based on continuous rhythm monitoring. | 2023 | Journal of cardiovascular electrophysiology | PubMed | nan |
| PMID:37237560.0 | Imbalance of Peripheral Temperature, Sympathovagal, and Cytokine Profile in Long COVID. | 2023 | Biology | PubMed | nan |
| PMID:37350725.0 | Usefulness of controlled breathing in psychiatry. A review of recent findings. Part 1 - Eastern approach. | 2023 | Psychiatria polska | PubMed | nan |
| PMID:37385729.0 | Digitally enabled acute care for atrial fibrillation: conception, feasibility and early outcomes of an AF virtual ward. | 2023 | Open heart | PubMed | nan |
| PMID:37431430.0 | Clinical trial reform in the post-COVID era. | 2023 | Therapeutic advances in medical oncology | PubMed | nan |
| PMID:37469536.0 | Ivabradine effects on COVID-19-associated postural orthostatic tachycardia syndrome: a single center prospective study. | 2023 | American journal of cardiovascular disease | Europe PMC; PubMed | nan |
| PMID:37569053.0 | Physical Activity in Long COVID: A Comparative Study of Exercise Rehabilitation Benefits in Patients with Long COVID, Coronary Artery Disease and Fibromyalgia. | 2023 | International journal of environmental research and public health | OpenAlex; PubMed | nan |
| PMID:37588158.0 | Usability of a continuous oxygen saturation device for home telemonitoring. | 2023 | Digital health | PubMed | nan |
| PMID:37597873.0 | Is a novel digital system for arm and hand rehabilitation suitable for stroke survivors? A qualitative process evaluation of OnTrack. | 2023 | BMJ open | PubMed | nan |
| PMID:37631774.0 | Telerehabilitation with ARC Intellicare to Cope with Motor and Respiratory Disabilities: Results about the Process, Usability, and Clinical Effect of the "Ricominciare" Pilot Study. | 2023 | Sensors (Basel, Switzerland) | PubMed | nan |
| PMID:37665334.0 | Digital Patient Reported Outcome Measures Platform for Post-COVID-19 Condition and Other Long-Term Conditions: User-Centered Development and Technical Description. | 2023 | JMIR human factors | PubMed | nan |
| PMID:37816223.0 | Rehabilitation Improves Persistent Symptoms of COVID-19: A Nonrandomized, Controlled, Open Study in Brazil. | 2024 | American journal of physical medicine & rehabilitation | PubMed | nan |
| PMID:37874735.0 | Leveraging mHealth to Mitigate the Impact of COVID-19 in Black American Communities: Qualitative Analysis. | 2023 | JMIR human factors | PubMed | nan |
| PMID:37947962.0 | Autonomic Manifestations of Long-COVID Syndrome. | 2023 | Current neurology and neuroscience reports | PubMed | nan |
| PMID:38105651.0 | Feasibility of a cannabidiol-dominant cannabis-based medicinal product for the treatment of long COVID symptoms: A single-arm open-label feasibility trial. | 2024 | British journal of clinical pharmacology | PubMed | nan |
| PMID:38213055.0 | Effectiveness of Internet-Based Group Supportive Psychotherapy on Psychic and Somatic Symptoms, Neutrophil-Lymphocyte Ratio, and Heart Rate Variability in Post COVID-19 Syndrome Patients. | 2023 | Acta medica Indonesiana | PubMed | nan |
| PMID:38243329.0 | Heart rate variability is reduced in COVID-19 survivors and associated with physical activity and fatigue. | 2024 | Physiological reports | PubMed | nan |
| PMID:38298551.0 | HEART Rate Variability Biofeedback for LOng COVID Dysautonomia (HEARTLOC): Results of a Feasibility Study. | 2024 | Advances in rehabilitation science and practice | Europe PMC; PubMed | NCT05228665 |
| PMID:38452119.0 | Understanding uptake of COVID-19 testing, vaccination, and boosters among Spanish-speaking Latines in the United States: Qualitative insights from Spanish speakers and key informants. | 2024 | PloS one | PubMed | nan |
| PMID:38458016.0 | An open trial of biofeedback for long COVID. | 2024 | Journal of psychosomatic research | PubMed | nan |
| PMID:38638805.0 | Machine learning algorithms for detection of visuomotor neural control differences in individuals with PASC and ME. | 2024 | Frontiers in human neuroscience | PubMed | nan |
| PMID:38643089.0 | Orthodontists' use of remote monitoring platforms pre-, amid, and post-COVID-19: a survey study. | 2024 | BMC oral health | PubMed | nan |
| NCT ID | Title | Status | Phase | Sponsor | Intervention |
|---|---|---|---|---|---|
| NCT05629793 | Differential Diagnosis of Persistent COVID-19 by Artificial Intelligence | UNKNOWN | nan | Fundacin Biomedica Galicia Sur | Experimental tests |
| ID | Title | Year | Journal | Source | Linked NCTs |
|---|---|---|---|---|---|
| PMID:39721883.0 | Evaluation of Vocal and Pulmonary Health Through Acoustic Analysis of Voice and Respiratory Measurements in People With Long COVID-19 Symptoms. | 2024 | Journal of voice : official journal of the Voice Foundation | PubMed | nan |
| PMID:40426703.0 | Digital Biomarkers and AI for Remote Monitoring of Fatigue Progression in Neurological Disorders: Bridging Mechanisms to Clinical Applications. | 2025 | Brain sciences | PubMed | nan |
| NCT ID | Title | Status | Phase | Sponsor | Intervention |
|---|---|---|---|---|---|
| NCT05104749 | Homeopathic Treatment of Post-acute COVID-19 Syndrome- A Pilot Randomized Controlled Trial | COMPLETED | PHASE3 | Southwest College of Naturopathic Medicine | Homeopathic Medication; Placebo |
| NCT05999435 | A DOUBLE-BLIND, RANDOMIZED, PLACEBO-CONTROLLED, ADAPTIVE PHASE 2/3 STUDY OF THE EFFICACY OF LAU-7b IN THE TREATMENT OF ADULTS WITH LONG COVID AND MODERATE TO SEVERE SYMPTOMS | COMPLETED | PHASE2; PHASE3 | Laurent Pharmaceuticals Inc. | LAU-7b for 3 cycles; LAU-7b for 1 cycle, then placebo; Placebo for 3 cycles |
| NCT05074888 | A Multicenter, Double-blind, Placebo-controlled, Parallel-group, Randomized Clinical Trial of Efficacy and Safety of Prospekta in the Treatment of Patients With Post-COVID-19 Asthe | COMPLETED | PHASE3 | Materia Medica Holding | Prospekta; Placebo |
| NCT05633407 | A Phase 2 Randomized, Double-blinded, Placebo-controlled Study to Evaluate the Efficacy and Safety of Efgartigimod IV in Adult Patients With Post-COVID-19 Postural Orthostatic Tach | COMPLETED | PHASE2 | argenx | Efgartigimod; Placebo |
| NCT05618587 | Effect of Low-dose Lithium Therapy on Long COVID Symptoms: a Randomized Controlled Trial. | COMPLETED | PHASE2 | State University of New York at Buffalo | Lithium; Placebo |
| NCT05592418 | A Randomized, Double Blind, Placebo Controlled Study to Evaluate the Efficacy and Safety of Ampligen® in Patients With Post-COVID Conditions | COMPLETED | PHASE2 | AIM ImmunoTech Inc. | Rintatolimod; Placebo / Normal Saline |
| NCT05576662 | Selective Trial Of Paxlovid for PASC (STOP-PASC): Randomized Double-Blind Placebo-Controlled Pilot Trial of Paxlovid for the Treatment of PASC | COMPLETED | PHASE2 | Stanford University | Nirmatrelvir; Placebo; Ritonavir |
| NCT05965726 | RECOVER-VITAL: A Platform Protocol for Evaluation of Interventions for Viral Persistence, Viral Reactivation, and Immune Dysregulation in Post-Acute Sequelae of SARS-CoV-2 Infectio | COMPLETED | PHASE2 | Kanecia Obie Zimmerman | Paxlovid; Ritonavir; Nirmatrelvir-matching placebo |
| NCT05126563 | A Randomized, Double-blinded, Single-center, Phase 2 Efficacy, and Safety Study of Allogeneic HB-adMSCs for the Treatment of Patients With Chronic Post-COVID-19 Syndrome. | COMPLETED | PHASE2 | Hope Biosciences Research Foundation | HB-adMSCs (allogeneic); Placebo |
| NCT05472090 | A Phase 2, 14-week Double-Blind, Randomized, Multicenter, Placebo-Controlled Study to Evaluate the Efficacy and Safety of TNX-102 SL Taken Daily at Bedtime in Patients With Multisi | COMPLETED | PHASE2 | Tonix Pharmaceuticals, Inc. | TNX-102 SL; Placebo SL Tablet |
| NCT06136871 | Cognitive Strategy Training in Post-COVID-19 Syndrome: A Feasibility Trial | COMPLETED | nan | University of Missouri-Columbia | CO-OP Procedures; Inactive Control Group |
| NCT06476496 | Pain Relief With Integrative Medicine (PRIMe)?: Feasibility of Acupuncture for Long COVID | COMPLETED | nan | University of Washington | Acupuncture |
| NCT05877508 | An Exploratory, Randomized, Double-Blind Placebo-Controlled Study to Assess the Safety of an Anti-SARS-CoV-2 Monoclonal Antibody and Response to Treatment in Individuals With Long | ACTIVE_NOT_RECRUITING | PHASE2 | Michael Peluso, MD | AER002; Placebo |
| NCT06161688 | Placebo-Controlled, Randomized Trial of Ensitrelvir (S-217622) for Viral Persistence and Inflammation in People Experiencing Long COVID (PREVAIL-LC) | ACTIVE_NOT_RECRUITING | PHASE2 | Timothy Henrich | Ensitrelvir; Placebo |
| NCT05445427 | Outcomes of Treatment With Vagal Nerve Stimulation in Post-COVID Syndrome: A Pilot Study | COMPLETED | nan | Mayo Clinic | vagal nerve stimulator |
| NCT05946551 | Feasibility Assessment of a Decentralized Platform Adaptive Double-Blind, Randomized Controlled Trial Investigating Repurposed Drugs in the Treatment of Post-Acute Sequelae of Coro | TERMINATED | PHASE3 | Emory University | Cetirizine; Famotidine; Cetirizine Placebo; Famotidine Placebo |
| NCT05918978 | Open-Label Extension Study to Evaluate the Long-term Safety and Efficacy of Efgartigimod in Adult Patients With Post-COVID-19 Postural Orthostatic Tachycardia Syndrome (PC-POTS) Wh | TERMINATED | PHASE2 | argenx | Efgartigimod |
| NCT05513560 | REcovering From COVID-19 Lingering Symptoms Adaptive Integrative Medicine (RECLAIM) | COMPLETED | PHASE2; PHASE3 | University Health Network, Toronto | Ibudilast; Pentoxifylline; Placebo |
| NCT05638633 | Prednisolone and Vitamin B1, B6, and B12 in Patients With Post-COVID-19-Syndrome (PC19S) - a Randomized Controlled Trial in Primary Care | COMPLETED | PHASE3 | Wuerzburg University Hospital | Prednisolone 20 mg/ 5 mg; Vitamin B compound (100mg B1, 50 mg B6, 500 µg B12); Placebo for Vitamin B compound; Placebo for Prednisolon |
| NCT05939622 | Prospective Randomized Double Blind Placebo Controlled Study of Efficacy of the Therapy With BRAINMAX® Using Functional Magnetic Resonance Imaging (fMRI) for the Treatment of Patie | COMPLETED | PHASE4 | Promomed, LLC | Structural and functional MRI; Ethyl methyl hydroxypyridine succinate + Meldonium; Placebo |
| NCT05524532 | Effect of Immulina Supplements on Inflammatory Biomarkers Correlated With Clinical Symptoms in Patients With Long COVID (PASC) | COMPLETED | PHASE3 | University of Mississippi Medical Center | Immulina TM; Placebo |
| NCT05890534 | Pycnogenol® in People With Post-COVID-19 Condition: a Quadruple-blind, Randomized, Placebo-controlled Trial | COMPLETED | PHASE3 | University of Zurich | Pycnogenol®; Placebo |
| NCT06128967 | An Adaptive, Randomized, doublE-blind, Placebo-controlled, Prospective, Pharmacological interVention Study In Participants With Long COVID-19 Syndrome: REVIVE-TOGETHER Trial | COMPLETED | PHASE3 | Cardresearch | Fluvoxamine Maleate 100 MG; Placebo; Metformin Extended Release Oral Tablet |
| NCT06404112 | RECOVER-SLEEP: A Platform Protocol for Evaluation of Interventions for Sleep Disturbances in Post-Acute Sequelae of SARS-CoV-2 Infection (PASC) | COMPLETED | PHASE2 | Duke University | Melatonin; Melantonin Placebo; Tailored lighting (TL) Active; Tailored lighting (TL) Placebo |
| NCT04705831 | A Randomized, Double Blind, Placebo Controlled, Cross-Over, Proof-of-Concept Study to Evaluate the Benefit of RUCONEST (C1 Esterase Inhibitor [Recombinant]) in Improving Neurologic | COMPLETED | PHASE2 | IMMUNOe Research Centers | Ruconest |
| NCT06316843 | A Randomized, Double-Blinded, Placebo-Controlled, Pilot Study of the Combination of Valacyclovir + Celecoxib (IMC-2) for the Treatment of Post-Acute Sequelae of SARS-CoV-2 Infectio | COMPLETED | PHASE2 | Bateman Horne Center | Valacyclovir celecoxib dose 1; Valacyclovir celecoxib dose 2; Placebo |
| NCT05668091 | An Interventional Decentralized Phase 2, Randomized, Double-Blind, 2-Arm Study to Investigate the Efficacy and Safety of Orally Administered Nirmatrelvir/Ritonavir Compared with Pl | COMPLETED | PHASE2 | Harlan M Krumholz | Nirmatrelvir; Ritonavir; Placebo |
| NCT06404099 | RECOVER-SLEEP: A Platform Protocol for Evaluation of Interventions for Sleep Disturbances in Post-Acute Sequelae of SARS-CoV-2 Infection (PASC) | COMPLETED | PHASE2 | Duke University | Modafinil; Modafinil Placebo; Solriamfetol; Solriamfetol Placebo |
| NCT05823896 | An Interventional, Double-Blinded, 2-Arm Study to Investigate the Efficacy of Orally Administered Nirmatrelvir/Ritonavir Compared with Placebo/Ritonavir in Non-hospitalized Adult P | COMPLETED | PHASE2 | Karolinska Institutet | Nirmatrelvir/ritonavir; Placebo/ritonavir |
| NCT05760092 | The Use of Photobiomodulation in the Treatment of Oral Complaints of Long COVID-19. A Randomized Controlled Trial. | COMPLETED | PHASE2 | University of Nove de Julho | Institutional standard treatment for xerostomia and Long Covid; Photobiomodulation Therapy; Placebo Photobiomodulation Therapy |
| NCT04842448 | Hyperbaric Oxygen for Treatment of Long COVID Syndrome; A Randomized, Placebo-Controlled, Double-Blind, Phase II Clinical Trial | COMPLETED | PHASE2 | Karolinska University Hospital | Hyperbaric oxygen; Sham treatment |
| NCT05152849 | A Randomized, Double-Blind, Placebo-Controlled Pilot Study to Evaluate the Efficacy, Safety, and Tolerability of AXA1125 in Subjects With Fatigue-Predominant Post-Acute Sequelae of | COMPLETED | PHASE2 | Axcella Health, Inc | AXA1125; Placebo |
| NCT06305806 | RECOVER-AUTONOMIC (Ivabradine): Randomized Trial of the Effect of Ivabradine Versus Placebo on Long COVID Symptoms | COMPLETED | PHASE2 | Kanecia Obie Zimmerman | Ivabradine; Ivabradine Placebo; Coordinated Care; Usual Care |
| NCT04944121 | A Phase 2, Double-blind, Placebo-controlled Study of RSLV-132 in Subjects With Post-acute COVID-19 (Long COVID) | COMPLETED | PHASE2 | Resolve Therapeutics | RSLV-132; Sodium Chloride 0.9% |
| NCT05212688 | A Randomised Phase II Study to Investigate the Effectiveness of ACUpuncture for the Relief of Long COVID Related Fatigue. | COMPLETED | PHASE2 | Royal Marsden NHS Foundation Trust | Acupuncture; Active Control |
| NCT05445674 | Plasma Exchange Therapy for Post- COVID-19 Condition: A Pilot, Randomized Double-Blind Study | COMPLETED | PHASE2 | Fundación FLS de Lucha Contra el Sida, las Enfermedades Infecciosas y la Promoción de la Salud y la Ciencia | Plasma Exchange Procedure; Sham Plasma Exchange Procedure |
| NCT07492953 | Using Enhanced External Counterpulsation to Recover Cardiovascular Function for Patient of Chronic Diseases | COMPLETED | nan | National Defense Medical Center, Taiwan | enhanced external counterpulsation |
| NCT05638620 | Evaluating the Effectiveness of Dual Sympathetic Blocks for Patients Experiencing Sympathetically-Mediated Symptoms From Post-Acute Sequelae of SARS-CoV-2 (PASC) | COMPLETED | PHASE1 | Jonathann Kuo, MD | stellate ganglion block with 0.5% bupivacaine |
| NCT06404073 | RECOVER-ENERGIZE: A Platform Protocol for Evaluation of Interventions for Exercise Intolerance in Post-Acute Sequelae of SARS-CoV-2 Infection (PASC) | COMPLETED | nan | Duke University | Structured Pacing; Usual Care |
| NCT05848401 | Biosound Therapy as a Treatment for Long COVID Patients: A Randomized Pilot Trial | COMPLETED | nan | Anxiety Relief Center | Biosound Therapy System |
| NCT05679505 | Effects of Vagus Nerve Stimulation in Post-COVID-19 Syndrome: A Randomized Controlled Trial | COMPLETED | nan | Bahçeşehir University | Auricular transcutaneous vagus nerve stimulation |
| NCT06721949 | Taurine Supplementation as a Novel Therapeutic Approach for Neurocognitive Symptoms in Long COVID | RECRUITING | PHASE2; PHASE3 | University of Alberta | Taurine; Placebo |
| NCT05196529 | Inspiratory Muscle Training in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) and COVID-19 Survivors | COMPLETED | nan | York University | Inspiratory muscle training |
| NCT06974058 | Evaluation of a Quercetin/Curcumin-Based Supplement for Mild to Moderate Long COVID-19 Symptoms: A Pragmatic, Interventional Clinical Study. | COMPLETED | nan | Liaquat University of Medical & Health Sciences | Nasafytol® (Quercetin/Curcumin Supplement) |
| NCT05119634 | The Effect of Whole Body Vibration Training in Individuals With Post COVID - 19 | COMPLETED | nan | Istanbul University - Cerrahpasa | whole body vibration training; home based exercises |
| NCT05107440 | BREATHE: A Mixed-methods Evaluation of a Virtual Self-management Program for People Living With Long COVID-19 in Alberta | COMPLETED | nan | University of Calgary | BREATHE |
| NCT05857124 | A Pilot Study Evaluating the Efficacy of the Vielight Neuro RX Gamma in the Treatment of Post COVID-19 Cognitive Impairment | COMPLETED | PHASE1 | Vielight Inc. | Vielight Neuro RX Gamma active device; Vielight Neuro RX Gamma sham device |
| NCT05218174 | Exercise Training and Functional, Cognitive, and Emotional Well-being in Adults with Post-Acute Sequelae of SARS-CoV-2 (COVID-19) Infection (PASC): a Randomized Controlled Trial | COMPLETED | nan | Baylor Research Institute | Exercise Prescription |
| NCT05703074 | The Efficacy and Safety of a Mental Intervention Program vs. Usual Care and Nicotinamide Riboside (NR) vs. Placebo for Improving Health-related Quality of Life in Long Covid: A 2 x | ACTIVE_NOT_RECRUITING | PHASE2 | University Hospital, Akershus | Nicotinamide Riboside (NR); Mind-body reprocessing therapy (MBRT); Care as usual; Placebo |
| NCT05840237 | REGAIN: A Randomized, Double Blind, Placebo Controlled Trial to Determine the Effects of Oxaloacetate on Improving Fatigue in Long COVID | COMPLETED | nan | Terra Biological LLC | Anhydrous Enol-Oxaloacetate, a "Medical Food"; White Rice Flour |
| ID | Title | Year | Journal | Source | Linked NCTs |
|---|---|---|---|---|---|
| PMID:32729939.0 | Postdischarge symptoms and rehabilitation needs in survivors of COVID-19 infection: A cross-sectional evaluation. | 2021 | Journal of medical virology | PubMed | NCT04841759 |
| PMID:33166287.0 | Persistent fatigue following SARS-CoV-2 infection is common and independent of severity of initial infection. | 2020 | PloS one | PubMed | nan |
| PMID:33562427.0 | Treatment, Persistent Symptoms, and Depression in People Infected with COVID-19 in Bangladesh. | 2021 | International journal of environmental research and public health | PubMed | nan |
| PMID:33764478.0 | Assessment of rehabilitation needs in patients after COVID-19: Development of the COVID-19-rehabilitation needs survey. | 2021 | Journal of rehabilitation medicine | PubMed | NCT06156241 |
| PMID:33791475.0 | The impact of COVID-19 shielding on the wellbeing, mental health and treatment adherence of adults with cystic fibrosis. | 2021 | Future healthcare journal | PubMed | nan |
| PMID:33865161.0 | Decreased quality of life and spirometric alterations even after mild-moderate COVID-19. | 2021 | Respiratory medicine | PubMed | nan |
| PMID:34037351.0 | [Post-COVID-19 asthenic syndrome]. | 2021 | Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova | PubMed | nan |
| PMID:34310576.0 | Work and social functioning in frontline healthcare workers during the covid-19 pandemic in Italy: role of acute post-traumatic stress, depressive and anxiety symptoms. | 2021 | Rivista di psichiatria | PubMed | nan |
| PMID:34425627.0 | [Complaints and clinical findings six months after COVID-19: outpatient follow-up at the University Medical Center Freiburg]. | 2021 | Deutsche medizinische Wochenschrift (1946) | PubMed | nan |
| PMID:34564089.0 | A Randomized Controlled Trial of the Efficacy of Systemic Enzymes and Probiotics in the Resolution of Post-COVID Fatigue. | 2021 | Medicines (Basel, Switzerland) | OpenAlex; PubMed | nan |
| PMID:34604980.0 | Fatigue in post-acute sequelae of SARS-CoV2 (PASC) treated with oxygen-ozone autohemotherapy - preliminary results on 100 patients. | 2021 | European review for medical and pharmacological sciences | PubMed | nan |
| PMID:34620202.0 | The impact of Post-COVID-Syndrome on functioning - results from a community survey in patients after mild and moderate SARS-CoV-2-infections in Germany. | 2021 | Journal of occupational medicine and toxicology (London, England) | PubMed | nan |
| PMID:34626924.0 | High prevalence of post COVID-19 fatigue in patients with type 2 diabetes: A case-control study. | 2021 | Diabetes & metabolic syndrome | PubMed | nan |
| PMID:34640447.0 | Effectiveness of a Primary Care Telerehabilitation Program for Post-COVID-19 Patients: A Feasibility Study. | 2021 | Journal of clinical medicine | OpenAlex; PubMed | nan |
| PMID:34698591.0 | The effects of respiratory exercises on partial pressures of gases and anxiety in the acute phase of COVID-19 infection. | 2022 | Physiotherapy theory and practice | PubMed | nan |
| PMID:34768725.0 | Post-COVID-19 Sydrome and Decrease in Health-Related Quality of Life in Kidney Transplant Recipients after SARS-COV-2 Infection-A Cohort Longitudinal Study from the North of Poland. | 2021 | Journal of clinical medicine | PubMed | nan |
| PMID:34862223.0 | Hyperbaric oxygen therapy for the treatment of long COVID: early evaluation of a highly promising intervention. | 2021 | Clinical medicine (London, England) | PubMed | nan |
| PMID:34939506.0 | Post-Covid-19 Syndrome: Improvements in Health-Related Quality of Life Following Psychology-Led Interdisciplinary Virtual Rehabilitation. | 2021 | Journal of primary care & community health | PubMed | nan |
| PMID:34961519.0 | Prevalence of and risk factors for depressive and anxiety symptoms in a large sample of Chinese adolescents in the post-COVID-19 era. | 2021 | Child and adolescent psychiatry and mental health | PubMed | nan |
| PMID:34982039.0 | An mHealth App for Fibromyalgia-like Post-COVID-19 Syndrome: Protocol for the Analysis of User Experience and Clinical Data. | 2022 | JMIR research protocols | PubMed | nan |
| PMID:35039178.0 | [Evolution and quality of life at three months after hospitalization for COVID pneumonia]. | 2022 | Rehabilitacion | PubMed | nan |
| PMID:35060361.0 | Long COVID-19: Objectifying most self-reported neurological symptoms. | 2022 | Annals of clinical and translational neurology | PubMed | nan |
| PMID:35096923.0 | Oral Bacteriotherapy Reduces the Occurrence of Chronic Fatigue in COVID-19 Patients. | 2021 | Frontiers in nutrition | PubMed | nan |
| PMID:35196130.0 | Transitioning from In-Person to Telemedicine Within Primary Care Behavioral Health During COVID-19. | 2022 | Population health management | PubMed | nan |
| PMID:35256450.0 | Long COVID and episodic disability: advancing the conceptualisation, measurement and knowledge of episodic disability among people living with Long COVID - protocol for a mixed-methods study. | 2022 | BMJ open | PubMed | nan |
| PMID:35298664.0 | [Persistent fatigue symptoms following COVID-19 infection in healthcare workers: risk factors and impact on quality of life]. | 2022 | Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz | PubMed | nan |
| PMID:35359819.0 | SingStrong-A singing and breathing retraining intervention for respiratory and other common symptoms of long COVID: A pilot study. | 2022 | Canadian journal of respiratory therapy : CJRT = Revue canadienne de la therapie respiratoire : RCTR | PubMed | nan |
| PMID:35449711.0 | An online survey data in senior high school students and their parents in China during the outbreak of coronavirus disease 2019. | 2022 | Data in brief | PubMed | nan |
| PMID:35473737.0 | Therapies for Long COVID in non-hospitalised individuals: from symptoms, patient-reported outcomes and immunology to targeted therapies (The TLC Study). | 2022 | BMJ open | PubMed | nan |
| PMID:35487736.0 | Light acupuncture and five-element music therapy for nurses' mental health and well-being during and post-COVID-19: protocol for a randomised cross-over feasibility study. | 2022 | BMJ open | PubMed | nan |
| PMID:35566536.0 | Fatigue Is a Major Symptom at COVID-19 Hospitalization Follow-Up. | 2022 | Journal of clinical medicine | PubMed | nan |
| PMID:35603810.0 | The modified COVID-19 Yorkshire Rehabilitation Scale (C19-YRSm) patient-reported outcome measure for Long Covid or Post-COVID-19 syndrome. | 2022 | Journal of medical virology | PubMed | NCT06054438 |
| PMID:35624973.0 | Association between Sleep Quality and Mental Health among Patients at a Post-COVID-19 Recovery Clinic. | 2022 | Brain sciences | PubMed | nan |
| PMID:35682280.0 | Construct Validity and Responsiveness of the COVID-19 Yorkshire Rehabilitation Scale (C19-YRS) in a Cohort of Italian Hospitalized COVID-19 Patients. | 2022 | International journal of environmental research and public health | PubMed | nan |
| PMID:35743346.0 | Olfactory Training in Post-COVID-19 Persistent Olfactory Disorders: Value Normalization for Threshold but Not Identification. | 2022 | Journal of clinical medicine | PubMed | nan |
| PMID:35764955.0 | Oxaloacetate Treatment For Mental And Physical Fatigue In Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) and Long-COVID fatigue patients: a non-randomized controlled clinical trial. | 2022 | Journal of translational medicine | Europe PMC; OpenAlex; PubMed | NCT04592354; NCT05840237 |
| PMID:35780095.0 | Electronic patient-reported monitoring of symptoms during follow-up of ovarian cancer patients: a feasibility study. | 2022 | BMC cancer | PubMed | nan |
| PMID:35822272.0 | Quality of life and persistence of COVID-19 symptoms 90 days after hospital discharge. | 2022 | The Journal of international medical research | PubMed | nan |
| PMID:35842844.0 | Postural balance and its association with functionality and quality of life in non-hospitalized patients with post-acute COVID-19 syndrome. | 2022 | Physiotherapy research international : the journal for researchers and clinicians in physical therap | PubMed | nan |
| PMID:35853037.0 | Efficacy of an asynchronous telerehabilitation program in post-COVID-19 patients: A protocol for a pilot randomized controlled trial. | 2022 | PloS one | OpenAlex; PubMed | NCT04794036 |
| PMID:35893858.0 | Use of 1-MNA to Improve Exercise Tolerance and Fatigue in Patients after COVID-19. | 2022 | Nutrients | PubMed | nan |
| PMID:35980383.0 | Post-COVID: effects of physical exercise on functional status and work ability in health care personnel. | 2023 | Disability and rehabilitation | PubMed | NCT04841759 |
| PMID:35986269.0 | Impact of long-COVID on health-related quality of life in Japanese COVID-19 patients. | 2022 | Health and quality of life outcomes | PubMed | nan |
| PMID:35987702.0 | Association between SARS-CoV-2 infection and de novo HLA donor specific antibody production in lung transplant recipients: Single-center study. | 2022 | Human immunology | PubMed | nan |
| PMID:35994177.0 | Coenzyme Q10 + alpha lipoic acid for chronic COVID syndrome. | 2023 | Clinical and experimental medicine | PubMed | nan |
| PMID:36011559.0 | Effects of Pre-Existing Mental Conditions on Fatigue and Psychological Symptoms Post-COVID-19. | 2022 | International journal of environmental research and public health | OpenAlex; PubMed | nan |
| PMID:36012033.0 | Application of an EMG-Rehabilitation Robot in Patients with Post-Coronavirus Fatigue Syndrome (COVID-19)-A Feasibility Study. | 2022 | International journal of environmental research and public health | Europe PMC; OpenAlex; PubMed | NCT05130736 |
| PMID:36029623.0 | Prevalence, trajectory over time, and risk factor of post-COVID-19 fatigue. | 2022 | Journal of psychiatric research | PubMed | nan |
| PMID:36035510.0 | Seven Months after Mild COVID-19: A Single-Centre Controlled Follow-Up Study in the District of Constance (FSC19-KN). | 2022 | International journal of clinical practice | PubMed | nan |
| PMID:36036410.0 | [Effectiveness of the anxiolytic Anvifen in the treatment of post-COVID brain fog]. | 2022 | Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova | PubMed | nan |
| NCT ID | Title | Status | Phase | Sponsor | Intervention |
|---|---|---|---|---|---|
| NCT05999435 | A DOUBLE-BLIND, RANDOMIZED, PLACEBO-CONTROLLED, ADAPTIVE PHASE 2/3 STUDY OF THE EFFICACY OF LAU-7b IN THE TREATMENT OF ADULTS WITH LONG COVID AND MODERATE TO SEVERE SYMPTOMS | COMPLETED | PHASE2; PHASE3 | Laurent Pharmaceuticals Inc. | LAU-7b for 3 cycles; LAU-7b for 1 cycle, then placebo; Placebo for 3 cycles |
| NCT05074888 | A Multicenter, Double-blind, Placebo-controlled, Parallel-group, Randomized Clinical Trial of Efficacy and Safety of Prospekta in the Treatment of Patients With Post-COVID-19 Asthe | COMPLETED | PHASE3 | Materia Medica Holding | Prospekta; Placebo |
| NCT05592418 | A Randomized, Double Blind, Placebo Controlled Study to Evaluate the Efficacy and Safety of Ampligen® in Patients With Post-COVID Conditions | COMPLETED | PHASE2 | AIM ImmunoTech Inc. | Rintatolimod; Placebo / Normal Saline |
| NCT05576662 | Selective Trial Of Paxlovid for PASC (STOP-PASC): Randomized Double-Blind Placebo-Controlled Pilot Trial of Paxlovid for the Treatment of PASC | COMPLETED | PHASE2 | Stanford University | Nirmatrelvir; Placebo; Ritonavir |
| NCT05965726 | RECOVER-VITAL: A Platform Protocol for Evaluation of Interventions for Viral Persistence, Viral Reactivation, and Immune Dysregulation in Post-Acute Sequelae of SARS-CoV-2 Infectio | COMPLETED | PHASE2 | Kanecia Obie Zimmerman | Paxlovid; Ritonavir; Nirmatrelvir-matching placebo |
| NCT05877508 | An Exploratory, Randomized, Double-Blind Placebo-Controlled Study to Assess the Safety of an Anti-SARS-CoV-2 Monoclonal Antibody and Response to Treatment in Individuals With Long | ACTIVE_NOT_RECRUITING | PHASE2 | Michael Peluso, MD | AER002; Placebo |
| NCT04880161 | A Randomized, Double-Blinded, Placebo-Controlled Phase I Study to Evaluate the Safety and Efficacy of Ampion in Patients With Prolonged Respiratory Symptoms Due to COVID-19 (Long C | COMPLETED | PHASE1 | Ampio Pharmaceuticals. Inc. | Ampion; Placebo |
| NCT06161688 | Placebo-Controlled, Randomized Trial of Ensitrelvir (S-217622) for Viral Persistence and Inflammation in People Experiencing Long COVID (PREVAIL-LC) | ACTIVE_NOT_RECRUITING | PHASE2 | Timothy Henrich | Ensitrelvir; Placebo |
| NCT05205460 | Effectiveness of a 12-week Telerehabilitation Training in People With Long COVID: A Randomized Controlled Trial | COMPLETED | nan | Tri-Service General Hospital | Home-based telerehabilitation; Education and self-exercise |
| NCT05946551 | Feasibility Assessment of a Decentralized Platform Adaptive Double-Blind, Randomized Controlled Trial Investigating Repurposed Drugs in the Treatment of Post-Acute Sequelae of Coro | TERMINATED | PHASE3 | Emory University | Cetirizine; Famotidine; Cetirizine Placebo; Famotidine Placebo |
| NCT05513560 | REcovering From COVID-19 Lingering Symptoms Adaptive Integrative Medicine (RECLAIM) | COMPLETED | PHASE2; PHASE3 | University Health Network, Toronto | Ibudilast; Pentoxifylline; Placebo |
| NCT04988282 | Systemic Corticosteroids in Treatment of Post-COVID-19 Interstitial Lung Disease | COMPLETED | PHASE4 | Turkish Thoracic Society | Methylprednisolone Tablet |
| NCT05890534 | Pycnogenol® in People With Post-COVID-19 Condition: a Quadruple-blind, Randomized, Placebo-controlled Trial | COMPLETED | PHASE3 | University of Zurich | Pycnogenol®; Placebo |
| NCT06383819 | Multicenter, Randomized, Double-blind, Placebo-controlled Parallel-group Study to Evaluate the Efficacy and Safety of Longidaza® for the Treatment of Patients With Residual Changes | COMPLETED | PHASE3 | NPO Petrovax | Longidaza®; Placebo |
| NCT05619653 | Randomised Placebo Controlled Clinical Trial of Efficacy of MYOcardial Protection in Patients With Postacute inFLAMmatory Cardiac involvEment Due to COVID-19 | ACTIVE_NOT_RECRUITING | PHASE3 | Valentina Puentmann | Prednisolone; Losartan |
| NCT05618574 | Nitrite Supplementation to Mitigate Fatigability and Increase Function in Long COVID Patients | COMPLETED | PHASE2 | VA Office of Research and Development | 140 ml per day of Beet-It nitrate beverage (James White Drinks Ltd., Ipswich, UK); 210 ml of nitrate-depleted placebo |
| NCT05823896 | An Interventional, Double-Blinded, 2-Arm Study to Investigate the Efficacy of Orally Administered Nirmatrelvir/Ritonavir Compared with Placebo/Ritonavir in Non-hospitalized Adult P | COMPLETED | PHASE2 | Karolinska Institutet | Nirmatrelvir/ritonavir; Placebo/ritonavir |
| NCT05152849 | A Randomized, Double-Blind, Placebo-Controlled Pilot Study to Evaluate the Efficacy, Safety, and Tolerability of AXA1125 in Subjects With Fatigue-Predominant Post-Acute Sequelae of | COMPLETED | PHASE2 | Axcella Health, Inc | AXA1125; Placebo |
| NCT05430152 | A Double Blind Randomized Trial of Low-dose Naltrexone for Post-COVID Fatigue Syndrome | COMPLETED | PHASE2 | Luis Nacul | Low-Dose Naltrexone; Placebo |
| NCT05323331 | Effects of Circuit Training Program on Cardiopulmonary Parameters and Functional Capacity in Post COVID 19 Patients | COMPLETED | nan | Riphah International University | Circuit Training Exercise Program; Aerobic Training Exercise Program |
| NCT06840873 | Effectiveness of a 8-week Tele-Rehabilitative Exercise Training Program on Fatigue, Symptom Severity, and Quality of Life in Nurses With Long COVID: A Randomized Controlled Trial | COMPLETED | nan | Shang-Lin Chiang | wearable device; Healthy consulation |
| NCT07492953 | Using Enhanced External Counterpulsation to Recover Cardiovascular Function for Patient of Chronic Diseases | COMPLETED | nan | National Defense Medical Center, Taiwan | enhanced external counterpulsation |
| NCT05638620 | Evaluating the Effectiveness of Dual Sympathetic Blocks for Patients Experiencing Sympathetically-Mediated Symptoms From Post-Acute Sequelae of SARS-CoV-2 (PASC) | COMPLETED | PHASE1 | Jonathann Kuo, MD | stellate ganglion block with 0.5% bupivacaine |
| NCT06404073 | RECOVER-ENERGIZE: A Platform Protocol for Evaluation of Interventions for Exercise Intolerance in Post-Acute Sequelae of SARS-CoV-2 Infection (PASC) | COMPLETED | nan | Duke University | Structured Pacing; Usual Care |
| NCT05299333 | Comparison of the Effectiveness of Pulmonary Telerehabilitation and Physical Activity Recommendations in Patients With Pulmonary Fibrosis Due to COVID-19 | COMPLETED | nan | Istanbul University - Cerrahpasa | Exercise |
| NCT06721949 | Taurine Supplementation as a Novel Therapeutic Approach for Neurocognitive Symptoms in Long COVID | RECRUITING | PHASE2; PHASE3 | University of Alberta | Taurine; Placebo |
| NCT05119634 | The Effect of Whole Body Vibration Training in Individuals With Post COVID - 19 | COMPLETED | nan | Istanbul University - Cerrahpasa | whole body vibration training; home based exercises |
| NCT05107440 | BREATHE: A Mixed-methods Evaluation of a Virtual Self-management Program for People Living With Long COVID-19 in Alberta | COMPLETED | nan | University of Calgary | BREATHE |
| NCT05218174 | Exercise Training and Functional, Cognitive, and Emotional Well-being in Adults with Post-Acute Sequelae of SARS-CoV-2 (COVID-19) Infection (PASC): a Randomized Controlled Trial | COMPLETED | nan | Baylor Research Institute | Exercise Prescription |
| NCT05216549 | Water and Land-based Exercise for Children With Post COVID-19 Condition | COMPLETED | nan | Józef Piłsudski University of Physical Education | Water-based exercise; Land-based exercise |
| NCT05840237 | REGAIN: A Randomized, Double Blind, Placebo Controlled Trial to Determine the Effects of Oxaloacetate on Improving Fatigue in Long COVID | COMPLETED | nan | Terra Biological LLC | Anhydrous Enol-Oxaloacetate, a "Medical Food"; White Rice Flour |
| NCT06330376 | Diaphragmatic Breathing Exercises for Post-COVID-19 Diaphragmatic Dysfunction (DD) | COMPLETED | nan | University of Minnesota | Usual care of traditional treatment; Specific DB program/Diaphragmatic manipulation program |
| NCT06952127 | Pilot Study Evaluating the Feasibility and Appropriateness of a Telerehabilitation Exercise Program in People With Post-COVID-19 Sequelae: a Single-center Randomized Trial. | COMPLETED | nan | Centre intégré universitaire de santé et de services sociaux de la Mauricie-et-du-Centre-du-Québec | Rehabilitation program |
| NCT05866224 | Effects of a Telerehabilitation Program and Detraining on Cardiorespiratory Fitness in Patients With Post-COVID-19 Sequelae | COMPLETED | nan | Campus docent Sant Joan de Déu-Universitat de Barcelona | Telerehabilitation program |
| NCT05973136 | A Pilot Study to Evaluate the Implantation and the Impact of a Hybrid Telerehabilitation Program Based on Cardiopulmonary Rehabilitation Principles for People With Post-COVID Affec | COMPLETED | nan | Université de Sherbrooke | Telerehabilitation program based on cardiorespiratory principles |
| NCT06535165 | Effect of 14-day Red Beetroot Juice Intake on Physical Function, Gut Microbiota Composition, and Systemic Inflammation in Adults With Long COVID-19 | COMPLETED | nan | Catholic University of the Sacred Heart | Red Beetroot Juice; Placebo |
| NCT05710770 | Double-blinded, Randomized, Sham-controlled Trial of Immunoadsorption (IA) in Patients With Chronic Fatigue Syndrome (CFS) Including Patients With Post-acute COVID-19 CFS (PACS-CFS | COMPLETED | nan | Charite University, Berlin, Germany | Immunoadsorption |
| NCT06165835 | Study on Post-Acute COVID-19 Syndrome in Improvement of COVID-19 Rehabilitated Patients by Respiratory Training | COMPLETED | nan | Tri-Service General Hospital | breathing training |
| NCT06004310 | Effect of Pulmonary Rehabilitation Among Post-COVID-19 Patients in a Tertiary Care Hospital in Bangladesh: A Quasi-Experimental Study | COMPLETED | nan | Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh | Pulmonary Rehabilitation |
| NCT05244044 | Changes in Functional Exercise Capacity After PUlmonary REhabilitation in Primary Care: a Randomized, Controlled, Multicenter, Pragmatic Trial in 134 Patients With Long COVID (PuRe | COMPLETED | nan | University Hospital, Antwerp | Pulmonary rehabilitation in primary care |
| NCT07280572 | RECLAIM: an Adaptive Platform Trial for the Evaluation of Treatments for Post-Acute Sequelae of SARS-CoV-2 Infection (PASC) | ENROLLING_BY_INVITATION | PHASE3 | Janneke van de Wijgert | Metformin; colchicine |
| NCT07508332 | Lung Boost Trainer Versus Incentive Spirometer on Spiro-metric Indices in Post COVID-19 Hemiplegic Cerebral Palsy Children; Randomized Controlled Trial | COMPLETED | nan | Cairo University | Lung boost trainer (LBT); Incentive Spirometer Training ( IST); Traditional Respiratory Physical Therapy Protocol (TRPT) |
| NCT06814379 | Rehabilitation of Fatigue in Patients With Post-COVID-19 Syndrome | COMPLETED | nan | Universidad de Granada | Rehabilitation; Virtual reality based rehabilitation |
| NCT07184398 | Use of a Cysteine-rich Whey Protein Isolate (Immunocal®) in Post COVID-19 Cognitive Impairment | COMPLETED | nan | Universidad Libre seccional Cali | Intervention with Consolidated Cysteine (Immunocal) 20 g per day; Cognitive rehabilitation workshops |
| NCT05373407 | A Randomized Controlled Trial Examining the Impact of Low Versus Moderate-intensity Aerobic Training in Post-discharge COVID-19 Older Subjects | COMPLETED | nan | University of Hail | aerobic exercise |
| NCT05699538 | Fatigue and Fatigability in Veterans Following SARS-CoV-2 Infection | COMPLETED | nan | VA Office of Research and Development | Minimal-Dose Home-Based Resistance Exercise |
| NCT05282199 | Efficacy of Inspiratory Muscle Training (IMT) on Sleep Quality, Exercise Tolerance and Pulmonary Radioaerosol Deposition Pattern in Post COVID-19 Infection Subjects | COMPLETED | nan | Universidade Federal de Pernambuco | INSPIRATORY MUSCLE TRAINING |
| NCT04841759 | The Effects of a Multi-factorial Rehabilitation Program for Healthcare Workers Suffering From Post-COVID-19 Fatigue Syndrome | COMPLETED | nan | Medical University of Vienna | Exercise |
| NCT05848518 | Effect of Different Types of Supervised Exercise Programs on Cardiorespiratory and Muscular Fitness, Pain, Fatigue, Mental Health and Inflammatory and Oxidative Stress Biomarkers i | COMPLETED | nan | Campus docent Sant Joan de Déu-Universitat de Barcelona | Rehabilitation program |
| NCT05697640 | A Parallel-group Treatment, Phase 2a, Double-blind, Placebo-controlled 2-arm Study to Show Improvement of Physical Function in SF-36 (SF-36-PF) in Participants Treated With Vericig | ACTIVE_NOT_RECRUITING | PHASE2 | Charite University, Berlin, Germany | Vericiguat Oral Tablet |
| ID | Title | Year | Journal | Source | Linked NCTs |
|---|---|---|---|---|---|
| PMID:32431134.0 | How the COVID-19 infection tsunami revolutionized the work of respiratory physiotherapists: an experience from Northern Italy. | 2020 | Monaldi archives for chest disease = Archivio Monaldi per le malattie del torace | PubMed | nan |
| PMID:33247653.0 | Beyond COVID-19: Evidence-Based Consensus Statement on the Role of Physiotherapy in Pulmonary Rehabilitation in the Indian Context. | 2020 | The Journal of the Association of Physicians of India | PubMed | nan |
| PMID:33331718.0 | [Exercise capacity after mechanical ventilation because of COVID-19: Cardiopulmonary exercise tests in clinical rehabilitation]. | 2020 | Nederlands tijdschrift voor geneeskunde | PubMed | nan |
| PMID:33536937.0 | Hyperventilation: A Possible Explanation for Long-Lasting Exercise Intolerance in Mild COVID-19 Survivors? | 2020 | Frontiers in physiology | PubMed | nan |
| PMID:33642858.0 | Pulmonary Rehabilitation in a Post-COVID-19 World: Telerehabilitation as a New Standard in Patients with COPD. | 2021 | International journal of chronic obstructive pulmonary disease | PubMed | nan |
| PMID:33645261.0 | Use of sit-to-stand test to assess the physical capacity and exertional desaturation in patients post COVID-19. | 2021 | Chronic respiratory disease | PubMed | nan |
| PMID:34080125.0 | Extrapulmonary features of post-COVID-19 patients: muscle function, physical activity, mood, and sleep quality. | 2022 | Irish journal of medical science | PubMed | nan |
| PMID:34140706.0 | Post-COVID-19 rehabilitation - a Polish pilot program. | 2021 | Medycyna pracy | PubMed | nan |
| PMID:34237048.0 | Outcomes Among Patients Referred to Outpatient Rehabilitation Clinics After COVID-19 diagnosis - United States, January 2020-March 2021. | 2021 | MMWR. Morbidity and mortality weekly report | PubMed | nan |
| PMID:34481432.0 | [Correction of mitochondrial dysfunction in the complex rehabilitation of COVID-19]. | 2021 | Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova | PubMed | nan |
| PMID:34551948.0 | Adjunctive inspiratory muscle training for patients with COVID-19 (COVIDIMT): protocol for randomised controlled double-blind trial. | 2021 | BMJ open | PubMed | nan |
| PMID:34640447.0 | Effectiveness of a Primary Care Telerehabilitation Program for Post-COVID-19 Patients: A Feasibility Study. | 2021 | Journal of clinical medicine | OpenAlex; PubMed | nan |
| PMID:34664483.0 | Do not forget the lungs: preliminary feasibility study on I/E mode physiotherapy for people recovering from COVID-19. | 2022 | Panminerva medica | PubMed | nan |
| PMID:34682970.0 | A Comprehensive Examination of Severely Ill ME/CFS Patients. | 2021 | Healthcare (Basel, Switzerland) | Europe PMC; PubMed | nan |
| PMID:34689061.0 | Respiratory rehabilitation for Covid-19 related persistent dyspnoea: A one-year experience. | 2021 | Respiratory medicine | PubMed | nan |
| PMID:34698591.0 | The effects of respiratory exercises on partial pressures of gases and anxiety in the acute phase of COVID-19 infection. | 2022 | Physiotherapy theory and practice | PubMed | nan |
| PMID:34718282.0 | Overview of Symptoms of Ongoing Symptomatic and Post-COVID-19 Patients Who Were Reffered to Pulmonary Rehabilitation - First Single-Centre Experience in Croatia. | 2021 | Psychiatria Danubina | PubMed | nan |
| PMID:34821709.0 | Post-Acute Sequelae of COVID-19 and Cardiovascular Autonomic Dysfunction: What Do We Know? | 2021 | Journal of cardiovascular development and disease | Europe PMC; PubMed | NCT05566379 |
| PMID:34827194.0 | Subclinical Myocardial Dysfunction in Patients Recovered from COVID-19 Disease: Correlation with Exercise Capacity. | 2021 | Biology | PubMed | nan |
| PMID:34945095.0 | Long COVID a New Derivative in the Chaos of SARS-CoV-2 Infection: The Emergent Pandemic? | 2021 | Journal of clinical medicine | PubMed | nan |
| PMID:35019775.0 | From heart to muscle: pathophysiological mechanisms underlying long-term physical sequelae from SARS-CoV-2 infection. | 2022 | Journal of applied physiology (Bethesda, Md. : 1985) | PubMed | nan |
| PMID:35055495.0 | Physical Fitness Differences, Amenable to Hypoxia-Driven and Sarcopenia Pathophysiology, between Sleep Apnea and COVID-19. | 2022 | International journal of environmental research and public health | PubMed | nan |
| PMID:35160223.0 | Pain Burden in Post-COVID-19 Syndrome following Mild COVID-19 Infection. | 2022 | Journal of clinical medicine | PubMed | nan |
| PMID:35232954.0 | [Post-covid syndrome after icu admission. Parameters related to a better physical recovery after 4 months.]. | 2022 | Revista espanola de salud publica | PubMed | nan |
| PMID:35272262.0 | The effectiveness of pulmonary rehabilitation for Post-COVID symptoms: A rapid review of the literature. | 2022 | Respiratory medicine | PubMed | nan |
| PMID:35287333.0 | Long-Term COVID 19 Sequelae in Adolescents: the Overlap with Orthostatic Intolerance and ME/CFS. | 2022 | Current pediatrics reports | Europe PMC; PubMed | nan |
| PMID:35291305.0 | Swimming Exercise for Patients With Long-Term Respiratory Post COVID-19 Complications: Further Thinking on the Pulmonary Rehabilitation. | 2022 | Archivos de bronconeumologia | PubMed | nan |
| PMID:35364291.0 | Cardiorespiratory physiology, exertional symptoms, and psychological burden in post-COVID-19 fatigue. | 2022 | Respiratory physiology & neurobiology | PubMed | nan |
| PMID:35418075.0 | Establishing a Post-Acute Covid-19 AHP Led Rehabilitation Clinic. | 2022 | Irish medical journal | PubMed | nan |
| PMID:35464473.0 | Persistent Lung Injury and Prothrombotic State in Long COVID. | 2022 | Frontiers in immunology | PubMed | nan |
| PMID:35473371.0 | Impact of surgical mask on performance and cardiorespiratory responses to submaximal exercise in COVID-19 patients near hospital discharge: A randomized crossover trial. | 2022 | Clinical rehabilitation | PubMed | nan |
| PMID:35543533.0 | Impaired exercise capacity in post-COVID-19 syndrome: the role of VWF-ADAMTS13 axis. | 2022 | Blood advances | PubMed | nan |
| PMID:35608204.0 | The effect of medium-term recovery status after COVID-19 illness on cardiopulmonary exercise capacity in a physically active adult population. | 2022 | Journal of applied physiology (Bethesda, Md. : 1985) | PubMed | nan |
| PMID:35616253.0 | Provision of pulmonary rehabilitation in Latin America 18 months after the COVID-19 pandemic: A survey of the Latin American Thoracic Association. | 2022 | Chronic respiratory disease | PubMed | nan |
| PMID:35649438.0 | The Effects of Exercise Therapy Moderated by Sex in Rehabilitation of COVID-19. | 2022 | International journal of sports medicine | PubMed | nan |
| PMID:35775163.0 | Long-term pulmonary sequelae in adolescents post-SARS-CoV-2 infection. | 2022 | Pediatric pulmonology | PubMed | nan |
| PMID:35833897.0 | Can aquatic exercises contribute to the improvement of the gait stereotype function in patients with Long COVID outcomes? | 2022 | European journal of translational myology | PubMed | nan |
| PMID:35893858.0 | Use of 1-MNA to Improve Exercise Tolerance and Fatigue in Patients after COVID-19. | 2022 | Nutrients | PubMed | nan |
| PMID:35925074.0 | [Post-COVID syndrome with fatigue and exercise intolerance: myalgic encephalomyelitis/chronic fatigue syndrome]. | 2022 | Innere Medizin (Heidelberg, Germany) | Europe PMC; PubMed | nan |
| PMID:35971155.0 | Prevention and early treatment of the long-term physical effects of COVID-19 in adults: design of a randomised controlled trial of resistance exercise-CISCO-21. | 2022 | Trials | PubMed | NCT04900961 |
| PMID:35980383.0 | Post-COVID: effects of physical exercise on functional status and work ability in health care personnel. | 2023 | Disability and rehabilitation | PubMed | NCT04841759 |
| PMID:36012085.0 | Proprietary Model of Qualification for In-Hospital Rehabilitation after COVID-19. | 2022 | International journal of environmental research and public health | PubMed | nan |
| PMID:36035510.0 | Seven Months after Mild COVID-19: A Single-Centre Controlled Follow-Up Study in the District of Constance (FSC19-KN). | 2022 | International journal of clinical practice | PubMed | nan |
| PMID:36039884.0 | When and how important is anti-fibrotic therapy in the post-COVID-19 period? | 2022 | Bratislavske lekarske listy | PubMed | nan |
| PMID:36083812.0 | [Hypoxic training in rehabilitation of patients at the early stages of recovery after SARS-CoV-2 pneumonia]. | 2022 | Voprosy kurortologii, fizioterapii, i lechebnoi fizicheskoi kultury | PubMed | nan |
| PMID:36088642.0 | Effects of continuous aerobic training associated with resistance training on maximal and submaximal exercise tolerance, fatigue, and quality of life of patients post-COVID-19. | 2023 | Physiotherapy research international : the journal for researchers and clinicians in physical therap | PubMed | nan |
| PMID:36111386.0 | Rehabilitation for post-COVID-19 condition through a supervised exercise intervention: A randomized controlled trial. | 2022 | Scandinavian journal of medicine & science in sports | Europe PMC; OpenAlex; PubMed | NCT05961462 |
| PMID:36141693.0 | Cardiopulmonary Exercise Testing Distinguishes between Post-COVID-19 as a Dysfunctional Syndrome and Organ Pathologies. | 2022 | International journal of environmental research and public health | PubMed | nan |
| PMID:36169159.0 | Multi-disciplinary collaborative consensus guidance statement on the assessment and treatment of postacute sequelae of SARS-CoV-2 infection (PASC) in children and adolescents. | 2022 | PM & R : the journal of injury, function, and rehabilitation | OpenAlex; PubMed | nan |
| PMID:36191860.0 | Home-based respiratory muscle training on quality of life and exercise tolerance in long-term post-COVID-19: Randomized controlled trial. | 2023 | Annals of physical and rehabilitation medicine | PubMed | nan |
| NCT ID | Title | Status | Phase | Sponsor | Intervention |
|---|---|---|---|---|---|
| NCT04141696 | A Proof-of-Concept Trial on the Effect of Ketamine on Fatigue | COMPLETED | PHASE1; PHASE2 | National Institute of Nursing Research (NINR) | Ketamine; Midazolam |
| NCT05973136 | A Pilot Study to Evaluate the Implantation and the Impact of a Hybrid Telerehabilitation Program Based on Cardiopulmonary Rehabilitation Principles for People With Post-COVID Affec | COMPLETED | nan | Université de Sherbrooke | Telerehabilitation program based on cardiorespiratory principles |
| NCT06393790 | Health Effects of a Strength Training Protocol in Women With Fibromyalgia and Healthy Individuals. | COMPLETED | nan | Catholic University of Murcia | FMG (Fibromyalgia group); HG (Healthy group) |
| NCT05273372 | A Randomized Double Blind Placebo Controlled Trial to Determine the Effects of Oxaloacetate on Improving Fatigue in ME/CFS | COMPLETED | nan | Terra Biological LLC | Placebo; Medical Food - Anhydrous Enol-Oxaloacetate |
| NCT06635928 | Assessing Fatigue and Attention in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Patients Before and After Treatment With Bright Light Therapy: a Prospective Randomized Contro | COMPLETED | nan | Medical University of Vienna | Bright light therapy |
| NCT06575920 | Breathing Therapy for Patients With Medically Unexplained Physical Symptoms and Dysfunctional Breathing: A Pilot and Feasibility Study | COMPLETED | nan | University of Agder | Breathing excercizes |
| NCT05507190 | Self-management of Post COVID-19 Syndrome Using Wearable Biometric Technology | COMPLETED | nan | University of Manitoba | Self-management of post COVID-19 respiratory outcomes |
| NCT05172206 | Symptom-based Rehabilitation Compared to Usual Care in Post-COVID - a Randomized Controlled Trial | COMPLETED | nan | Schön Klinik Berchtesgadener Land | symptom-focused rehabilitation; usual care |
| NCT05204511 | Exercise and Post-COVID/Long-COVID: Effects of Different Training Modalities on Physical Performance, Heart Rate Variability, Inflammation, Health-Related Quality of Life, Cognitiv | COMPLETED | nan | University of Vienna | endurance training; concurrent training |
| NCT06978582 | Effectiveness and Safety of a Tele-rehabilitation Program Based on Mindful and Conscious Movement-based Exercise vs Conventional Low-intensity Exercise on Fatigue and Related Varia | ACTIVE_NOT_RECRUITING | nan | University of Seville | Mindful and conscious movement-based exercise; Conventional exercise |
| NCT06968104 | Stimulation of the Transcutaneous Auricular Vagus Nerve for Improvement of Symptoms in Patients With Post-COVID Syndrome and ME/CFS | ACTIVE_NOT_RECRUITING | nan | University of Luxembourg | transcutaneous vagus nerve stimulation; transcutaneous vagus nerve stimulation |
| NCT06366724 | LIFT: Life Improvement Trial | RECRUITING | PHASE2 | Brigham and Women's Hospital | Pyridostigmine; Low-Dose Naltrexone; Placebo |
| NCT04935307 | Central Processing of Odour Stimuli in Patients With Multi-systemic Functional Somatic Disorder, Multiple Chemical Sensitivityor Post Covid Compared to Healthy Controls - the Pilot | ACTIVE_NOT_RECRUITING | nan | University of Aarhus | MRI and paraclinical tests |
| NCT07278206 | Mitigating Cognitive Problems and Fatigue With Brain Stimulation in Long COVID | RECRUITING | nan | Amsterdam UMC, location VUmc | Repetitive Transcranial Magnetic Stimulation; Sham device |
| NCT06292377 | Better Understanding of Fatigue After STroke | RECRUITING | nan | Brugmann University Hospital | ECG; Transthoracic echography (TTE); Blood sampling |
| NCT07009691 | Heart Rate Variability as an Autonomic Marker of Improvement in ME/CFS in a Hydrogen Water Treatment Study | RECRUITING | nan | Stony Brook University | Hydrogen water which is prepared from an OTC supplement. |
| NCT05741112 | The Long COVID-19 Wearable Device Study | RECRUITING | nan | Scripps Translational Science Institute | Wearable device |
| NCT06585254 | Use of Transcutaneous Vagus Nerve Stimulation in Reducing the Symptoms of Long COVID Patients Who Fulfill Diagnostic Criteria for ME/CFS | RECRUITING | nan | Icahn School of Medicine at Mount Sinai | Transcutaneous vagus nerve stimulator |
| NCT05899595 | Effects of a Personalized Physical Training to Reduce Fatigue in Chronic Fatigue Patients: a Randomized Controlled Trial. | TERMINATED | nan | Centre Hospitalier Universitaire de Saint Etienne | Exercise protocol |
| NCT04363606 | Chronic Fatigue Etiology and Recovery in Covid-19 Patients : the Role of Fatigability and Stay in Intensive Care | TERMINATED | nan | Centre Hospitalier Universitaire de Saint Etienne | Questionnaires; blood test; Maximal effort test; actigraphy; Neuromuscular evaluation; stool analysis; food diary |
| NCT06386133 | Chronic Fatigue in Multiple Sclerosis: Validating Clinical Performance, Economic, and Organizational Benefits of MSCopilot Boost Compared to Standard Care | NOT_YET_RECRUITING | nan | Ad scientiam | MS Boost; Standard of care |
| NCT07454395 | Investigating the Effect of Swimming on Autonomic and Symptomatic Responses in Individuals With Myalgic Encephalomyelitis/Chronic Fatigue Syndrome | SUSPENDED | nan | Simon Fraser University | Swimming; Cycling |
| NCT03849326 | Chronic Fatigue Etiology in Intensive Care Unit Survivors: the Role of Neuromuscular Function | WITHDRAWN | nan | Centre Hospitalier Universitaire de Saint Etienne | Questionnaires; blood test; Maximal effort test; actigraphy; Neuromuscular evaluation |
| NCT05454683 | Effect of Melatonin Plus Zinc Supplementation on Fatigue, Pain, Sleep Disturbances, Anxiety and Depression, and Autonomic Dysfunction in ME/CFS: a Randomized, Double-blind, Placebo | UNKNOWN | nan | Laboratorios Viñas, S.A. | melatonin plus zinc; isomaltose and magnesium stearate |
| NCT05851846 | Amygdala Insula Retraining in the Management of Long COVID Symptoms | UNKNOWN | nan | Miami VA Healthcare System | Amygdala insula retraining |
| NCT05397626 | Biofeedback and Hydrogen Water as Treatments for Chronic Fatigue Syndrome | UNKNOWN | PHASE1 | Stony Brook University | Heart Rhythm Biofeedback; Hydrogen Water; Combined treatment: Heart rhythm biofeedback plus hydrogen water |
| ID | Title | Year | Journal | Source | Linked NCTs |
|---|---|---|---|---|---|
| PMID:31957647.0 | Parasympathetic activity is reduced during slow-wave sleep, but not resting wakefulness, in patients with chronic fatigue syndrome. | 2020 | Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Me | PubMed | nan |
| PMID:32504895.0 | Patterns of daytime physical activity in patients with chronic fatigue syndrome. | 2020 | Journal of psychosomatic research | PubMed | nan |
| PMID:32857640.0 | Fatigue-Related Cognitive-Behavioral Factors in Survivors of Childhood Cancer: Comparison with Chronic Fatigue Syndrome and Survivors of Adult-Onset Cancer. | 2021 | Journal of adolescent and young adult oncology | PubMed | nan |
| PMID:33168001.0 | Accurate and objective determination of myalgic encephalomyelitis/chronic fatigue syndrome disease severity with a wearable sensor. | 2020 | Journal of translational medicine | PubMed | nan |
| PMID:33264751.0 | Towards personalized assessment of fatigue perpetuating factors in patients with chronic fatigue syndrome using ecological momentary assessment: A pilot study. | 2021 | Journal of psychosomatic research | PubMed | nan |
| PMID:34602086.0 | Cognitive-behavioral therapy for management of mental health and stress-related disorders: Recent advances in techniques and technologies. | 2021 | BioPsychoSocial medicine | PubMed | nan |
| PMID:37300057.0 | Major Depressive Disorder and Chronic Fatigue Syndrome Show Characteristic Heart Rate Variability Profiles Reflecting Autonomic Dysregulations: Differentiation by Linear Discriminant Analysis. | 2023 | Sensors (Basel, Switzerland) | PubMed | nan |
| PMID:38638805.0 | Machine learning algorithms for detection of visuomotor neural control differences in individuals with PASC and ME. | 2024 | Frontiers in human neuroscience | PubMed | nan |
| PMID:38777281.0 | Exercise does not cause post-exertional malaise in Veterans with Gulf War Illness: A randomized, controlled, dose-response, crossover study. | 2024 | Brain, behavior, and immunity | PubMed | nan |
| PMID:38858151.0 | Faecal microbiota transplantation (FMT) in Norwegian outpatients with mild to severe myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS): protocol for a 12-month randomised double-blind placebo-controlled trial. | 2024 | BMJ open | Europe PMC; PubMed | nan |
| PMID:39374820.0 | Inspiratory muscle training improves autonomic function in myalgic encephalomyelitis/chronic fatigue syndrome and post-acute sequelae of SARS-CoV-2: A pilot study. | 2025 | Respiratory physiology & neurobiology | Europe PMC; PubMed | NCT05196529 |
| PMID:39493638.0 | Web-based telemedicine approach for treatment of post-COVID-19 in Thuringia (WATCH). | 2024 | Digital health | Europe PMC; PubMed | nan |
| PMID:39529893.0 | An Adaptive Pacing Intervention for Adults Living With Long COVID: A Narrative Study of Patient Experiences of Using the PaceMe app. | 2024 | Journal of patient experience | Europe PMC; OpenAlex; PubMed | nan |
| PMID:39895557.0 | Cerebral Blood Flow in Orthostatic Intolerance. | 2025 | Journal of the American Heart Association | Europe PMC; PubMed | nan |
| PMID:40315935.0 | Effects of acupuncture and moxibustion on heart rate variability in chronic fatigue syndrome patients: Regulating the autonomic nervous system in a clinical randomized controlled trial. | 2025 | Complementary therapies in medicine | OpenAlex; PubMed | nan |
| PMID:40806985.0 | The Use of Heart Rate Variability-Biofeedback (HRV-BF) as an Adjunctive Intervention in Chronic Fatigue Syndrome (CSF/ME) in Long COVID: Results of a Phase II Controlled Feasibility Trial. | 2025 | Journal of clinical medicine | Europe PMC; PubMed | nan |
| PMID:41030648.0 | Relationship between post-COVID-19 symptoms and daily physical activity. | 2025 | Frontiers in rehabilitation sciences | Europe PMC; PubMed | nan |
| PMID:41132394.0 | Wearable technology in the management of complex chronic illness: preliminary survey results on self-reported outcomes. | 2025 | Frontiers in digital health | Europe PMC; PubMed | NCT07454395 |
| PMID:41373279.0 | Safety and Effectiveness of an Exercise-Based Telerehabilitation Program in Myalgic Encephalomyelitis and Post COVID Syndrome: Protocol for a Randomized Controlled Clinical Trial. | 2025 | Healthcare (Basel, Switzerland) | Europe PMC; PubMed | NCT06978582 |
| PMID:42073381.0 | Digital Approaches for Managing Brain Fog in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS): Interventions, Monitoring, and Future Directions. | 2026 | Life (Basel, Switzerland) | Europe PMC; PubMed | nan |
| PMID:41601198.0 | Associations between heart rate and physical activity in people with post-COVID-19 condition accounting for myalgic encephalomyelitis/chronic fatigue syndrome symptoms. | 2026 | nan | Europe PMC | nan |
| DOI | The Locus Coeruleus Norepinephrine Depletion Hypothesis of ME/CFS: A Mechanistic Model with Testable Predictions and Multimodal Study Plans (Protocol Framework) | 2025 | nan | Preprint (medRxiv/bioRxiv) | nan |
| DOI | Effect of Percutaneous Auricular Nerve Stimulation on Fatigue in Adults with Post-COVID Fatigue (PAuSing-pCF): Results of a Randomised, Sham-Controlled Trial | 2026 | nan | Preprint (medRxiv/bioRxiv) | nan |
| DOI | Hydrogen water as a treatment for myalgic encephalomyelitis/chronic fatigue syndrome: a pilot randomized trial | 2022 | Fatigue Biomedicine Health & Behavior | OpenAlex | nan |
| DOI | Antioxidants and Long Covid | 2022 | OALib | OpenAlex | nan |
| NCT ID | Title | Status | Phase | Sponsor | Intervention |
|---|---|---|---|---|---|
| NCT04141696 | A Proof-of-Concept Trial on the Effect of Ketamine on Fatigue | COMPLETED | PHASE1; PHASE2 | National Institute of Nursing Research (NINR) | Ketamine; Midazolam |
| NCT04313972 | IC PaIN Trial: Interstitial Cystitis Pain Improvement With Naltrexone, the Effect of Low Dose Naltrexone on Symptoms and Pain of Patients With Interstitial Cystitis/Painful Bladder | TERMINATED | PHASE4 | Endeavor Health | low-dose naltrexone; Placebo oral tablet |
| NCT05638633 | Prednisolone and Vitamin B1, B6, and B12 in Patients With Post-COVID-19-Syndrome (PC19S) - a Randomized Controlled Trial in Primary Care | COMPLETED | PHASE3 | Wuerzburg University Hospital | Prednisolone 20 mg/ 5 mg; Vitamin B compound (100mg B1, 50 mg B6, 500 µg B12); Placebo for Vitamin B compound; Placebo for Prednisolon |
| NCT05939622 | Prospective Randomized Double Blind Placebo Controlled Study of Efficacy of the Therapy With BRAINMAX® Using Functional Magnetic Resonance Imaging (fMRI) for the Treatment of Patie | COMPLETED | PHASE4 | Promomed, LLC | Structural and functional MRI; Ethyl methyl hydroxypyridine succinate + Meldonium; Placebo |
| NCT04622293 | A Double-Blind, Randomized, Placebo-Controlled, Single-Center, Flexible Titration Study Evaluating the Efficacy of Solriamfetol in Treating Fatigue and Cognitive Symptoms in Adults | COMPLETED | PHASE4 | Rochester Center for Behavioral Medicine | Solriamfetol Oral Tablet [Sunosi]; Placebo |
| NCT06245642 | A Multi-center, Randomized, Double-blind, Positive Parallel Control Study of Compound Ciwujia Granules in the Treatment of Chronic Fatigue Syndrome (Spleen-kidney Deficiency Syndro | COMPLETED | PHASE4 | Heilongjiang Quanle Pharmaceutical Co., Ltd. | Compound Ciwujia Granules, Guipi Granules |
| NCT06128967 | An Adaptive, Randomized, doublE-blind, Placebo-controlled, Prospective, Pharmacological interVention Study In Participants With Long COVID-19 Syndrome: REVIVE-TOGETHER Trial | COMPLETED | PHASE3 | Cardresearch | Fluvoxamine Maleate 100 MG; Placebo; Metformin Extended Release Oral Tablet |
| NCT06721949 | Taurine Supplementation as a Novel Therapeutic Approach for Neurocognitive Symptoms in Long COVID | RECRUITING | PHASE2; PHASE3 | University of Alberta | Taurine; Placebo |
| NCT05196529 | Inspiratory Muscle Training in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) and COVID-19 Survivors | COMPLETED | nan | York University | Inspiratory muscle training |
| NCT05840237 | REGAIN: A Randomized, Double Blind, Placebo Controlled Trial to Determine the Effects of Oxaloacetate on Improving Fatigue in Long COVID | COMPLETED | nan | Terra Biological LLC | Anhydrous Enol-Oxaloacetate, a "Medical Food"; White Rice Flour |
| NCT05710770 | Double-blinded, Randomized, Sham-controlled Trial of Immunoadsorption (IA) in Patients With Chronic Fatigue Syndrome (CFS) Including Patients With Post-acute COVID-19 CFS (PACS-CFS | COMPLETED | nan | Charite University, Berlin, Germany | Immunoadsorption |
| NCT04308278 | Randomized, Placebo-controlled, Double Blind Study to Evaluate the Efficacy of 2LEBV® and 2LXFS® on Asthenia in Patients With an Epstein-Barr Virus Infection. | RECRUITING | PHASE4 | Labo'Life | 2LEBV® / 2LXFS®; Placebo |
| NCT05273372 | A Randomized Double Blind Placebo Controlled Trial to Determine the Effects of Oxaloacetate on Improving Fatigue in ME/CFS | COMPLETED | nan | Terra Biological LLC | Placebo; Medical Food - Anhydrous Enol-Oxaloacetate |
| NCT05697640 | A Parallel-group Treatment, Phase 2a, Double-blind, Placebo-controlled 2-arm Study to Show Improvement of Physical Function in SF-36 (SF-36-PF) in Participants Treated With Vericig | ACTIVE_NOT_RECRUITING | PHASE2 | Charite University, Berlin, Germany | Vericiguat Oral Tablet |
| NCT05841498 | A Single-blinded Sham-controlled Crossover Trial to Evaluate the Effect of Immunoadsorption on Post-Corona Virus Disease (COVID)-Syndrome | COMPLETED | nan | University Medical Center Mainz | Immunoadsorption; Sham-apheresis |
| NCT07524179 | The Effect of Therapeutic Touch on Sleep Quality and Fatigue Severity in Advanced Cancer Patients in the Palliative Care Setting: A Randomized Controlled Trial | COMPLETED | nan | Erzurum Technical University | Therapeutic Touch; Routine Palliative Care |
| NCT06635928 | Assessing Fatigue and Attention in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Patients Before and After Treatment With Bright Light Therapy: a Prospective Randomized Contro | COMPLETED | nan | Medical University of Vienna | Bright light therapy |
| NCT04158427 | Intestinal Microbiota and Chronic Fatigue Syndrome. Effect of Fecal Transplant on Health Related Quality of Life of the Patients With Chronic Fatigue Syndrome | COMPLETED | nan | Tampere University Hospital | Faecal transplantation; Placebo faecal transplantation |
| NCT06172803 | RESToRE: Restoring Energy With Sub-symptom Threshold Optimized Rehabilitation Exercise for Long COVID | COMPLETED | nan | Columbia University | Restoring Energy with Sub-symptom Threshold Aerobic Rehabilitation Exercise; Light Stretching/Breathing Exercises |
| NCT05954325 | Extracorporal Apheresis Hannover Medical School Study in Post COVID-19 Patients | COMPLETED | nan | Hannover Medical School | Immunoadsorption vs. sham immunoadsorption |
| NCT06064838 | Effects of Cacao Flavonoids in Long COVID-19 Patients with Chronic Fatigue (FLALOC) | COMPLETED | nan | Guillermo Ceballos Reyes | Flavonoids |
| NCT05172206 | Symptom-based Rehabilitation Compared to Usual Care in Post-COVID - a Randomized Controlled Trial | COMPLETED | nan | Schön Klinik Berchtesgadener Land | symptom-focused rehabilitation; usual care |
| NCT07263854 | Effects of Lower Extremity Neuromuscular Facilitation on Gait, Balance and Fatigue in Patients With Multiple Sclerosis: A Randomized Controlled Study | COMPLETED | nan | Sanko University | exercises |
| NCT05204511 | Exercise and Post-COVID/Long-COVID: Effects of Different Training Modalities on Physical Performance, Heart Rate Variability, Inflammation, Health-Related Quality of Life, Cognitiv | COMPLETED | nan | University of Vienna | endurance training; concurrent training |
| NCT04301609 | Randomized, Comparative, Double-blind, and Placebo-controlled Clinical Trial to Assess the Improvement of Fatigue, Sleep, Anxiety / Depression, Neurovegetatives Alterations and Qua | COMPLETED | nan | Vitae Health Innovation | Active; Placebo |
| NCT04435002 | The Effect of Acupressure on Fatigue in Individuals With Chronic Fatigue Syndrome | COMPLETED | nan | Istanbul Medipol University Hospital | Acupressure |
| NCT05956405 | Retraining of the Amygdala and Insula for the Treatment of Persistent Covid | COMPLETED | nan | Hospital Miguel Servet | AIR + Mindfulness; Relaxation condition |
| NCT06073002 | Effects of a Home-Based Exercise Intervention on Physical Function, Symptoms and Health-Related Quality of Life in Subjects with Long Covid | ACTIVE_NOT_RECRUITING | nan | University of Vienna | home-based concurrent exercise |
| NCT05967052 | Investigation of Pregabalin Therapy and Complex Rehabilitation in Treating Chronic Fatigue Associated With Post-COVID Syndrome | RECRUITING | PHASE2 | National Institute of Geriatrics, Rheumatology and Rehabilitation, Poland | Pregabalin; Independent walking training; Placebo; Gradual movement therapy in the ward; Telerehabilitation; Psychotherapy |
| NCT06511050 | Investigating the Effects of Lumbrokinase in Adults With Long Covid, Post-treatment Lyme Disease Syndrome, and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome | RECRUITING | PHASE1; PHASE2 | Icahn School of Medicine at Mount Sinai | Lumbrokinase |
| NCT06978582 | Effectiveness and Safety of a Tele-rehabilitation Program Based on Mindful and Conscious Movement-based Exercise vs Conventional Low-intensity Exercise on Fatigue and Related Varia | ACTIVE_NOT_RECRUITING | nan | University of Seville | Mindful and conscious movement-based exercise; Conventional exercise |
| NCT06739720 | A Randomized, Waitlist-controlled Clinical Study on the Efficacy and Safety of Lingzhi-containing Dietary Supplement CP003 on Chronic Fatigue and Post-COVID Fatigue | NOT_YET_RECRUITING | PHASE2; PHASE3 | The University of Hong Kong | LingZhi capsule |
| NCT06952413 | An Exploratory, Placebo-controlled, Double-blind, Phase II Study of the Efficacy and Safety for Rituximab (Genetical Recombination) in Myalgia Encephalomyelitis/Chronic Fatigue Syn | RECRUITING | PHASE2 | National Center of Neurology and Psychiatry, Japan | Rituximab(Genetical Recombination); Placebo |
| NCT06968104 | Stimulation of the Transcutaneous Auricular Vagus Nerve for Improvement of Symptoms in Patients With Post-COVID Syndrome and ME/CFS | ACTIVE_NOT_RECRUITING | nan | University of Luxembourg | transcutaneous vagus nerve stimulation; transcutaneous vagus nerve stimulation |
| NCT05791812 | Application of Direct Current Transcranial stImulation, Remotely superVised in Chronic fATiguE - Heimanwendung Der Transkraniellen Gleichstromstimulation Zur Behandlung Der Chronis | ACTIVE_NOT_RECRUITING | nan | University of Regensburg | home-based transcranial direct current stimulation (tDCS) |
| NCT06366724 | LIFT: Life Improvement Trial | RECRUITING | PHASE2 | Brigham and Women's Hospital | Pyridostigmine; Low-Dose Naltrexone; Placebo |
| NCT04935307 | Central Processing of Odour Stimuli in Patients With Multi-systemic Functional Somatic Disorder, Multiple Chemical Sensitivityor Post Covid Compared to Healthy Controls - the Pilot | ACTIVE_NOT_RECRUITING | nan | University of Aarhus | MRI and paraclinical tests |
| NCT05719493 | Effectiveness and Health Benefits of a Nutritional, Chronobiological and Physical Exercise Primary Care Intervention in Fibromyalgia and Chronic Fatigue Syndrome: SYNCHRONIZE + Mix | ACTIVE_NOT_RECRUITING | nan | Fundacio d'Investigacio en Atencio Primaria Jordi Gol i Gurina | multicomponent treatment |
| NCT05167227 | The Long COVID and Fatiguing Illness Recovery Program - A Pragmatic, Quality Improvement, Professional Cluster, Randomized Controlled Trial. | ACTIVE_NOT_RECRUITING | nan | Family Health Centers of San Diego | Extension for Community Healthcare Outcomes |
| NCT06170645 | Transcutaneous Vagus Nerve Stimulation as a Complementary Therapy to Exercise in Chronic Fatigue: Single-center, Controlled, Randomized, Blinded Study | RECRUITING | nan | Centre Hospitalier Universitaire de Saint Etienne | APA program; Active transcutaneous VNS; Sham transcutaneous VNS |
| NCT07285473 | Low-dose Naltrexone (LDN) for the Treatment of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS): Dose-Finding | NOT_YET_RECRUITING | PHASE2 | University of Alabama at Birmingham | Low-Dose Naltrexone, 1.5mg; Low-Dose Naltrexone, 3.0mg; Low-Dose Naltrexone, 4.5mg; Low-Dose Naltrexone, 6.0mg |
| NCT05168124 | Study to Determine the Effectiveness of Therapy Methods (acceptance Commitment Therapy, Micro Breaks) in Patients with Chronic Fatigue Syndrome/ Myalgic Encephalomyelitis | RECRUITING | nan | Sarah Schiebler | Acceptance Commitment Therapy for chronic fatigue; Micro breaks in everyday life for chronic fatigue |
| NCT07242573 | Evaluation of the Effect of Individualized Physical Training and Neuromodulation on Pain, Sleep and Fatigue in Patients With Fibromyalgia: a Randomized Controlled Trial | RECRUITING | nan | National Institute of Geriatrics, Rheumatology and Rehabilitation, Poland | Physical Training Program; NESA X-Signal; Conventional Physiotherapy |
| NCT07320937 | Effects of Yiqi Fuyuan Paste Formula in Chronic Fatigue Syndrome: A Randomized Double-Blind Controlled Clinical Trial. | ENROLLING_BY_INVITATION | nan | ShuGuang Hospital | "Yiqi Fuyuan Paste Formula" test group; Placebo(a look-alike substance that contains no drug) |
| NCT07278206 | Mitigating Cognitive Problems and Fatigue With Brain Stimulation in Long COVID | RECRUITING | nan | Amsterdam UMC, location VUmc | Repetitive Transcranial Magnetic Stimulation; Sham device |
| NCT05525598 | Internet-based Treatment for Patients Suffering From Severe Functional Somatic Disorders: A Randomized Controlled Trial. | RECRUITING | nan | University of Aarhus | "One step at a time"; "Get started" |
| NCT06147050 | Pilot Study of an Adaptive, Double-blind, Randomized, Placebo-controlled Study to Evaluate the Effect of Metformin in Reducing Fatigue in Long COVID Adolescent Patients With Chroni | UNKNOWN | PHASE3 | Purpose Life Sciences | Metformin; Placebo |
| NCT06292377 | Better Understanding of Fatigue After STroke | RECRUITING | nan | Brugmann University Hospital | ECG; Transthoracic echography (TTE); Blood sampling |
| NCT07352254 | OutreAch MediCal Care for HousEbound Patients With Post-COVID-19 Syndrome or ME/CFS of Any Cause | RECRUITING | nan | Hannover Medical School | online visit; No Interventions |
| NCT07009691 | Heart Rate Variability as an Autonomic Marker of Improvement in ME/CFS in a Hydrogen Water Treatment Study | RECRUITING | nan | Stony Brook University | Hydrogen water which is prepared from an OTC supplement. |
| ID | Title | Year | Journal | Source | Linked NCTs |
|---|---|---|---|---|---|
| PMID:32411717.0 | Intravenous Cyclophosphamide in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome. An Open-Label Phase II Study. | 2020 | Frontiers in medicine | Europe PMC; OpenAlex; PubMed | nan |
| PMID:32764516.0 | Autonomic Phenotypes in Chronic Fatigue Syndrome (CFS) Are Associated with Illness Severity: A Cluster Analysis. | 2020 | Journal of clinical medicine | PubMed | nan |
| PMID:32869588.0 | [Effect of ginger-separated moxibustion on fatigue, sleep quality and depression in patients with chronic fatigue syndrome: a randomized controlled trial]. | 2020 | Zhongguo zhen jiu = Chinese acupuncture & moxibustion | PubMed | nan |
| PMID:32930040.0 | Cognitive behavioural therapy for chronic fatigue and chronic fatigue syndrome: outcomes from a specialist clinic in the UK. | 2020 | Journal of the Royal Society of Medicine | PubMed | nan |
| PMID:33101925.0 | Effectiveness a herbal medicine (Sipjeondaebo-tang) on adults with chronic fatigue syndrome: A randomized, double-blind, placebo-controlled trial. | 2021 | Integrative medicine research | PubMed | nan |
| PMID:33114401.0 | Reliability and Validity of the Modified Korean Version of the Chalder Fatigue Scale (mKCFQ11). | 2020 | Healthcare (Basel, Switzerland) | PubMed | nan |
| PMID:33528911.0 | Open-label study with the monoamine stabilizer (-)-OSU6162 in myalgic encephalomyelitis/chronic fatigue syndrome. | 2021 | Brain and behavior | Europe PMC; PubMed | nan |
| PMID:33633851.0 | Chronic fatigue syndrome (CFS)/Myalgic Encephalomyelitis (ME) and Fibromyalgia (FM): the foundation of a relationship. | 2021 | British journal of pain | PubMed | nan |
| PMID:33895431.0 | Guided graded exercise self-help for chronic fatigue syndrome: Long term follow up and cost-effectiveness following the GETSET trial. | 2021 | Journal of psychosomatic research | PubMed | nan |
| PMID:34072494.0 | Tolerability and Efficacy of s.c. IgG Self-Treatment in ME/CFS Patients with IgG/IgG Subclass Deficiency: A Proof-of-Concept Study. | 2021 | Journal of clinical medicine | PubMed | nan |
| PMID:34444817.0 | Effect of Dietary Coenzyme Q10 Plus NADH Supplementation on Fatigue Perception and Health-Related Quality of Life in Individuals with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Prospective, Randomized, Double- | 2021 | Nutrients | Europe PMC; OpenAlex; PubMed | NCT05454683 |
| PMID:34498994.0 | Graded exercise therapy for patients with chronic fatigue syndrome in secondary care - a benchmarking study. | 2022 | Disability and rehabilitation | PubMed | nan |
| PMID:34604980.0 | Fatigue in post-acute sequelae of SARS-CoV2 (PASC) treated with oxygen-ozone autohemotherapy - preliminary results on 100 patients. | 2021 | European review for medical and pharmacological sciences | PubMed | nan |
| PMID:34901100.0 | A Botanical Product Containing Cistanche and Ginkgo Extracts Potentially Improves Chronic Fatigue Syndrome Symptoms in Adults: A Randomized, Double-Blind, and Placebo-Controlled Study. | 2021 | Frontiers in nutrition | OpenAlex; PubMed | nan |
| PMID:34939506.0 | Post-Covid-19 Syndrome: Improvements in Health-Related Quality of Life Following Psychology-Led Interdisciplinary Virtual Rehabilitation. | 2021 | Journal of primary care & community health | PubMed | nan |
| PMID:34987499.0 | Lasting Immunological Imprint of Primary Epstein-Barr Virus Infection With Associations to Chronic Low-Grade Inflammation and Fatigue. | 2021 | Frontiers in immunology | PubMed | nan |
| PMID:35011770.0 | Patients with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) Greatly Improved Fatigue Symptoms When Treated with Oxygen-Ozone Autohemotherapy. | 2021 | Journal of clinical medicine | Europe PMC; PubMed | nan |
| PMID:35011914.0 | Male vs. Female Differences in Responding to Oxygen-Ozone Autohemotherapy (O2-O3-AHT) in Patients with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS). | 2021 | Journal of clinical medicine | Europe PMC; PubMed | nan |
| PMID:35359819.0 | SingStrong-A singing and breathing retraining intervention for respiratory and other common symptoms of long COVID: A pilot study. | 2022 | Canadian journal of respiratory therapy : CJRT = Revue canadienne de la therapie respiratoire : RCTR | PubMed | nan |
| PMID:35473345.0 | Ginger-indirect moxibustion plus acupuncture versus acupuncture alone for chronic fatigue syndrome: a randomized controlled trial. | 2022 | Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan | OpenAlex; PubMed | nan |
| PMID:35535102.0 | Fatigue in Cirrhosis. | 2022 | Journal of clinical and experimental hepatology | PubMed | nan |
| PMID:35720086.0 | Altered Effective Connectivity of Resting-State Networks by Tai Chi Chuan in Chronic Fatigue Syndrome Patients: A Multivariate Granger Causality Study. | 2022 | Frontiers in neurology | PubMed | nan |
| PMID:35764955.0 | Oxaloacetate Treatment For Mental And Physical Fatigue In Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) and Long-COVID fatigue patients: a non-randomized controlled clinical trial. | 2022 | Journal of translational medicine | Europe PMC; OpenAlex; PubMed | NCT04592354; NCT05840237 |
| PMID:35847786.0 | The Qigong of Prolong Life With Nine Turn Method Relieve Fatigue, Sleep, Anxiety and Depression in Patients With Chronic Fatigue Syndrome: A Randomized Controlled Clinical Study. | 2022 | Frontiers in medicine | PubMed | nan |
| PMID:35893858.0 | Use of 1-MNA to Improve Exercise Tolerance and Fatigue in Patients after COVID-19. | 2022 | Nutrients | PubMed | nan |
| PMID:35911899.0 | Effects of the Prolong Life With Nine Turn Method (Yan Nian Jiu Zhuan) Qigong on Brain Functional Changes in Patients With Chronic Fatigue Syndrome in Terms of Fatigue and Quality of Life. | 2022 | Frontiers in neurology | OpenAlex; PubMed | nan |
| PMID:35994177.0 | Coenzyme Q10 + alpha lipoic acid for chronic COVID syndrome. | 2023 | Clinical and experimental medicine | PubMed | nan |
| PMID:36169159.0 | Multi-disciplinary collaborative consensus guidance statement on the assessment and treatment of postacute sequelae of SARS-CoV-2 infection (PASC) in children and adolescents. | 2022 | PM & R : the journal of injury, function, and rehabilitation | OpenAlex; PubMed | nan |
| PMID:36397215.0 | [Effect of electroacupuncture at back-shu points of five zang on fatigue status and cortical excitability in chronic fatigue syndrome]. | 2022 | Zhongguo zhen jiu = Chinese acupuncture & moxibustion | PubMed | nan |
| PMID:36454926.0 | Tai Chi increases functional connectivity and decreases chronic fatigue syndrome: A pilot intervention study with machine learning and fMRI analysis. | 2022 | PloS one | PubMed | nan |
| PMID:36461167.0 | Effect of using a structured pacing protocol on post-exertional symptom exacerbation and health status in a longitudinal cohort with the post-COVID-19 syndrome. | 2023 | Journal of medical virology | OpenAlex; PubMed | nan |
| PMID:36510244.0 | Clinical effects of wasabi extract containing 6-MSITC on myalgic encephalomyelitis/chronic fatigue syndrome: an open-label trial. | 2022 | BioPsychoSocial medicine | Europe PMC; OpenAlex; PubMed | nan |
| PMID:36657408.0 | Effects of Yijinjing Qigongin Alleviating Fatigue, Sleep Quality, and Health Status on Patients with Chronic Fatigue Syndrome: A Randomized, Controlled, and Parallel Group Clinical Study. | 2023 | Complementary medicine research | OpenAlex; PubMed | nan |
| PMID:36698810.0 | Improvement of Long COVID symptoms over one year. | 2022 | Frontiers in medicine | Europe PMC; PubMed | nan |
| PMID:36765375.0 | Symptom-based clusters in people with ME/CFS: an illustration of clinical variety in a cross-sectional cohort. | 2023 | Journal of translational medicine | Europe PMC; PubMed | nan |
| PMID:36977713.0 | Health outcomes of sensory hypersensitivities in myalgic encephalomyelitis/chronic fatigue syndrome and multiple sclerosis. | 2023 | Psychology, health & medicine | Europe PMC; PubMed | nan |
| PMID:37230457.0 | Effects of whole-body cryotherapy and static stretching are maintained 4 weeks after treatment in most patients with chronic fatigue syndrome. | 2023 | Cryobiology | PubMed | nan |
| PMID:37351826.0 | Implication of cognitive-behavioral stress management on anxiety, depression, and quality of life in acute myocardial infarction patients after percutaneous coronary intervention: a multicenter, randomized, controlled st | 2024 | Irish journal of medical science | PubMed | nan |
| PMID:37516837.0 | Randomized, double-blinded, placebo-controlled pilot study: efficacy of faecal microbiota transplantation on chronic fatigue syndrome. | 2023 | Journal of translational medicine | OpenAlex; PubMed | NCT04158427 |
| PMID:37573421.0 | A technology-enabled multi-disciplinary team-based care model for the management of Long COVID and other fatiguing illnesses within a federally qualified health center: protocol for a two-arm, single-blind, pragmatic, qu | 2023 | Trials | Europe PMC; OpenAlex; PubMed | NCT05167227 |
| PMID:37652910.0 | A synthetic data generation system for myalgic encephalomyelitis/chronic fatigue syndrome questionnaires. | 2023 | Scientific reports | Europe PMC; PubMed | nan |
| PMID:37862966.0 | A prospective randomized, double-blind placebo-controlled study to evaluate the effectiveness of neuroprotective therapy using functional brain MRI in patients with post-covid chronic fatigue syndrome. | 2023 | Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie | Europe PMC; PubMed | nan |
| PMID:38095411.0 | Oxygen-ozone autohemotherapy in breast cancer patients suffering from fatigue and musculoskeletal pain upon aromatase inhibitors treatment: a case-series study. | 2023 | European review for medical and pharmacological sciences | PubMed | nan |
| PMID:38127508.0 | Effectiveness of an online multicomponent program (FATIGUEWALK) for chronic fatigue syndrome: A randomized controlled trial. | 2024 | Health psychology : official journal of the Division of Health Psychology, American Psychological As | OpenAlex; PubMed | NCT04593225 |
| PMID:38191152.0 | Exploring the central mechanism of mind-regulation electroacupuncture in treatment of chronic fatigue syndrome with anxiety and depression comorbidity based on functional magnetic resonance imaging. | 2024 | Zhongguo zhen jiu = Chinese acupuncture & moxibustion | PubMed | nan |
| PMID:38282368.0 | Psychometric evaluation of the DePaul Symptom Questionnaire-Short Form (DSQ-SF) among adults with Long COVID, ME/CFS, and healthy controls: A machine learning approach. | 2024 | Journal of health psychology | Europe PMC; PubMed | nan |
| PMID:38407950.0 | Effects of the Prolong Life With Nine Turn-Method Qigong on Fatigue, Insomnia, Anxiety, and Gastrointestinal Disorders in Patients With Chronic Fatigue Syndrome: Protocol for a Randomized Controlled Trial. | 2024 | JMIR research protocols | OpenAlex; PubMed | nan |
| PMID:38429546.0 | Graded exercise therapy compared to activity management for paediatric chronic fatigue syndrome/myalgic encephalomyelitis: pragmatic randomized controlled trial. | 2024 | European journal of pediatrics | Europe PMC; OpenAlex; PubMed | nan |
| PMID:38447497.0 | Efficacy of aquatic vs land-based therapy for pain management in women with fibromyalgia: a randomised controlled trial. | 2024 | Physiotherapy | OpenAlex; PubMed | nan |
| PMID:38454468.0 | IA-PACS-CFS: a double-blinded, randomized, sham-controlled, exploratory trial of immunoadsorption in patients with chronic fatigue syndrome (CFS) including patients with post-acute COVID-19 CFS (PACS-CFS). | 2024 | Trials | Europe PMC; OpenAlex; PubMed | NCT05710770 |
| NCT ID | Title | Status | Phase | Sponsor | Intervention |
|---|---|---|---|---|---|
| NCT03674541 | The Exercise Response to Pharmacologic Cholinergic Stimulation in Myalgic Encephalomyelitis / Chronic Fatigue Syndrome | COMPLETED | PHASE2 | Brigham and Women's Hospital | Pyridostigmine Bromide; Placebo |
| NCT05430152 | A Double Blind Randomized Trial of Low-dose Naltrexone for Post-COVID Fatigue Syndrome | COMPLETED | PHASE2 | Luis Nacul | Low-Dose Naltrexone; Placebo |
| NCT06721949 | Taurine Supplementation as a Novel Therapeutic Approach for Neurocognitive Symptoms in Long COVID | RECRUITING | PHASE2; PHASE3 | University of Alberta | Taurine; Placebo |
| NCT05840237 | REGAIN: A Randomized, Double Blind, Placebo Controlled Trial to Determine the Effects of Oxaloacetate on Improving Fatigue in Long COVID | COMPLETED | nan | Terra Biological LLC | Anhydrous Enol-Oxaloacetate, a "Medical Food"; White Rice Flour |
| NCT05973136 | A Pilot Study to Evaluate the Implantation and the Impact of a Hybrid Telerehabilitation Program Based on Cardiopulmonary Rehabilitation Principles for People With Post-COVID Affec | COMPLETED | nan | Université de Sherbrooke | Telerehabilitation program based on cardiorespiratory principles |
| NCT05710770 | Double-blinded, Randomized, Sham-controlled Trial of Immunoadsorption (IA) in Patients With Chronic Fatigue Syndrome (CFS) Including Patients With Post-acute COVID-19 CFS (PACS-CFS | COMPLETED | nan | Charite University, Berlin, Germany | Immunoadsorption |
| NCT05697640 | A Parallel-group Treatment, Phase 2a, Double-blind, Placebo-controlled 2-arm Study to Show Improvement of Physical Function in SF-36 (SF-36-PF) in Participants Treated With Vericig | ACTIVE_NOT_RECRUITING | PHASE2 | Charite University, Berlin, Germany | Vericiguat Oral Tablet |
| NCT04740736 | Cardiovascular Analysis of Post-exertional Malaise | COMPLETED | nan | Icahn School of Medicine at Mount Sinai | Saline Infusion |
| NCT05664711 | Effect of Stellate Ganglion Block on ME/CFS Symptoms and Metabolites | COMPLETED | PHASE1 | Neuroversion, Inc. | Bupivacaine Injection |
| NCT04378634 | The Influence of Epigenetic Modifications and Post-Exertional Malaise in People With Myalgic Encephalomyelitis/Chronic Fatigue Syndrome | COMPLETED | nan | Vrije Universiteit Brussel | Exercise; Mental Stress Test |
| NCT04741841 | Effect of Probiotic Food Supplement "GutMagnific™" in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS), Also Known as Post-viral Fatigue Syndrome, and Comorbid | COMPLETED | nan | ImmuneBiotech Medical Sweden AB | GutMagnific™ H.; GutMagnific™ L.; Placebo |
| NCT06172803 | RESToRE: Restoring Energy With Sub-symptom Threshold Optimized Rehabilitation Exercise for Long COVID | COMPLETED | nan | Columbia University | Restoring Energy with Sub-symptom Threshold Aerobic Rehabilitation Exercise; Light Stretching/Breathing Exercises |
| NCT05507190 | Self-management of Post COVID-19 Syndrome Using Wearable Biometric Technology | COMPLETED | nan | University of Manitoba | Self-management of post COVID-19 respiratory outcomes |
| NCT05204511 | Exercise and Post-COVID/Long-COVID: Effects of Different Training Modalities on Physical Performance, Heart Rate Variability, Inflammation, Health-Related Quality of Life, Cognitiv | COMPLETED | nan | University of Vienna | endurance training; concurrent training |
| NCT04797871 | Resistance Training Intervention on the Clinical Status in Patients With Post Discharge Symptoms After Covid-19: The "EXER-COVID Study" | COMPLETED | nan | Universidad Pública de Navarra | Resistance training; Standard care |
| NCT06073002 | Effects of a Home-Based Exercise Intervention on Physical Function, Symptoms and Health-Related Quality of Life in Subjects with Long Covid | ACTIVE_NOT_RECRUITING | nan | University of Vienna | home-based concurrent exercise |
| NCT06511050 | Investigating the Effects of Lumbrokinase in Adults With Long Covid, Post-treatment Lyme Disease Syndrome, and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome | RECRUITING | PHASE1; PHASE2 | Icahn School of Medicine at Mount Sinai | Lumbrokinase |
| NCT06952413 | An Exploratory, Placebo-controlled, Double-blind, Phase II Study of the Efficacy and Safety for Rituximab (Genetical Recombination) in Myalgia Encephalomyelitis/Chronic Fatigue Syn | RECRUITING | PHASE2 | National Center of Neurology and Psychiatry, Japan | Rituximab(Genetical Recombination); Placebo |
| NCT07468604 | A Randomized Controlled Trial for Cervicothoracic Sympathetic Chain Block Against Sham Injection Evaluation for Post COVID Condition: the CeASE RCT | NOT_YET_RECRUITING | PHASE4 | University Health Network, Toronto | 5 mL of 0.25% bupivacaine with epinephrine (1:200,000); Sham Group |
| NCT06968104 | Stimulation of the Transcutaneous Auricular Vagus Nerve for Improvement of Symptoms in Patients With Post-COVID Syndrome and ME/CFS | ACTIVE_NOT_RECRUITING | nan | University of Luxembourg | transcutaneous vagus nerve stimulation; transcutaneous vagus nerve stimulation |
| NCT06366724 | LIFT: Life Improvement Trial | RECRUITING | PHASE2 | Brigham and Women's Hospital | Pyridostigmine; Low-Dose Naltrexone; Placebo |
| NCT05167227 | The Long COVID and Fatiguing Illness Recovery Program - A Pragmatic, Quality Improvement, Professional Cluster, Randomized Controlled Trial. | ACTIVE_NOT_RECRUITING | nan | Family Health Centers of San Diego | Extension for Community Healthcare Outcomes |
| NCT06170645 | Transcutaneous Vagus Nerve Stimulation as a Complementary Therapy to Exercise in Chronic Fatigue: Single-center, Controlled, Randomized, Blinded Study | RECRUITING | nan | Centre Hospitalier Universitaire de Saint Etienne | APA program; Active transcutaneous VNS; Sham transcutaneous VNS |
| NCT05168124 | Study to Determine the Effectiveness of Therapy Methods (acceptance Commitment Therapy, Micro Breaks) in Patients with Chronic Fatigue Syndrome/ Myalgic Encephalomyelitis | RECRUITING | nan | Sarah Schiebler | Acceptance Commitment Therapy for chronic fatigue; Micro breaks in everyday life for chronic fatigue |
| NCT07491315 | Is Post-exertional Symptom Exacerbation Specific to Patients With Myalgic Encephalomyelitis / Chronic Fatigue Syndrome? A Study Comparing Patients With Myalgic Encephalomyelitis / | RECRUITING | nan | Hôpital Européen Marseille | Exercise test on ergocycle; Near Infrared Spectroscopy (NIRS) |
| NCT05236465 | A 3-day Course for Adults With Chronic Fatigue Syndrome/Myalgic Encephalopathy (CFS/ME): a Randomized Controlled Trial | RECRUITING | nan | Norwegian University of Science and Technology | A 3-day course; Waiting list |
| NCT05741112 | The Long COVID-19 Wearable Device Study | RECRUITING | nan | Scripps Translational Science Institute | Wearable device |
| NCT06585254 | Use of Transcutaneous Vagus Nerve Stimulation in Reducing the Symptoms of Long COVID Patients Who Fulfill Diagnostic Criteria for ME/CFS | RECRUITING | nan | Icahn School of Medicine at Mount Sinai | Transcutaneous vagus nerve stimulator |
| NCT04363606 | Chronic Fatigue Etiology and Recovery in Covid-19 Patients : the Role of Fatigability and Stay in Intensive Care | TERMINATED | nan | Centre Hospitalier Universitaire de Saint Etienne | Questionnaires; blood test; Maximal effort test; actigraphy; Neuromuscular evaluation; stool analysis; food diary |
| NCT07621068 | Hyperbaric Oxygen Therapy for Chronic Fatigue Syndrome (CFS) - A Prospective, Randomized, Double-Blind, Sham-Controlled Study | NOT_YET_RECRUITING | nan | Assaf-Harofeh Medical Center | Hyperbaric oxygen therapy; SHAM treatment |
| NCT07454395 | Investigating the Effect of Swimming on Autonomic and Symptomatic Responses in Individuals With Myalgic Encephalomyelitis/Chronic Fatigue Syndrome | SUSPENDED | nan | Simon Fraser University | Swimming; Cycling |
| NCT03849326 | Chronic Fatigue Etiology in Intensive Care Unit Survivors: the Role of Neuromuscular Function | WITHDRAWN | nan | Centre Hospitalier Universitaire de Saint Etienne | Questionnaires; blood test; Maximal effort test; actigraphy; Neuromuscular evaluation |
| NCT05534997 | Effect of Intensive Combined Rehabilitation Therapy for Patients With Post COVID 19 Chronic Fatigue Syndrome | UNKNOWN | nan | Cairo University | intensive combined rehabilitation therapy |
| NCT05454683 | Effect of Melatonin Plus Zinc Supplementation on Fatigue, Pain, Sleep Disturbances, Anxiety and Depression, and Autonomic Dysfunction in ME/CFS: a Randomized, Double-blind, Placebo | UNKNOWN | nan | Laboratorios Viñas, S.A. | melatonin plus zinc; isomaltose and magnesium stearate |
| NCT05130099 | A Complex Intervention for a Complex Symptom - a Randomized Controlled Trial in Chronically Fatigued Lymphoma Survivors | UNKNOWN | nan | Oslo University Hospital | Interdisciplinary complex intervention |
| NCT05668039 | Enhanced External Counterpulsation (EECP/ECPT) to Treat Long-COVID-19 Fatigue - a Randomized Controlled Trial | UNKNOWN | nan | Sheba Medical Center | Enhanced external counterpulsation |
| NCT05753228 | In Vivo Investigation on Mitochondrial Dysfunction in Post-COVID Fatigue and Cancer Fatigue. | UNKNOWN | nan | National University Hospital, Singapore | MRI/ 3D Arterial Spin Labelling (ASL) and 1H magnetic resonance spectroscopy (MRS); Chalder Fatigue Scale; Health Questionnaire (EQ-5D-5L); Hamilton Depression |
| NCT05629884 | Efficacy of a Physical and Respiratory Rehabilitation Program (COPERIA-REHAB) for Patients With Persistent COVID-19 (SARS-CoV-2). | UNKNOWN | nan | Fundacin Biomedica Galicia Sur | COPERIA-REHAB |
| NCT05851846 | Amygdala Insula Retraining in the Management of Long COVID Symptoms | UNKNOWN | nan | Miami VA Healthcare System | Amygdala insula retraining |
| ID | Title | Year | Journal | Source | Linked NCTs |
|---|---|---|---|---|---|
| PMID:31884303.0 | Post-exertional malaise is associated with greater symptom burden and psychological distress in patients diagnosed with Chronic Fatigue Syndrome. | 2020 | Journal of psychosomatic research | PubMed | nan |
| PMID:32568143.0 | Post-exertional symptoms distinguish Myalgic Encephalomyelitis/Chronic Fatigue Syndrome subjects from healthy controls. | 2020 | Work (Reading, Mass.) | OpenAlex; PubMed | nan |
| PMID:33119613.0 | Effect of disease duration in a randomized Phase III trial of rintatolimod, an immune modulator for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome. | 2020 | PloS one | Europe PMC; PubMed | nan |
| PMID:33184353.0 | Profile of circulating microRNAs in myalgic encephalomyelitis and their relation to symptom severity, and disease pathophysiology. | 2020 | Scientific reports | PubMed | nan |
| PMID:33274349.0 | Informatics Inference of Exercise-Induced Modulation of Brain Pathways Based on Cerebrospinal Fluid Micro-RNAs in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome. | 2020 | Network and systems medicine | PubMed | nan |
| PMID:33829023.0 | Reduced Endothelial Function in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome-Results From Open-Label Cyclophosphamide Intervention Study. | 2021 | Frontiers in medicine | Europe PMC; OpenAlex; PubMed | nan |
| PMID:34368926.0 | Exploring Symptom Fluctuations and Triggers in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Using Novel Patient-Centred N-of-1 Observational Designs: A Protocol for a Feasibility and Acceptability Study. | 2022 | The patient | Europe PMC; PubMed | nan |
| PMID:34682970.0 | A Comprehensive Examination of Severely Ill ME/CFS Patients. | 2021 | Healthcare (Basel, Switzerland) | Europe PMC; PubMed | nan |
| PMID:34901100.0 | A Botanical Product Containing Cistanche and Ginkgo Extracts Potentially Improves Chronic Fatigue Syndrome Symptoms in Adults: A Randomized, Double-Blind, and Placebo-Controlled Study. | 2021 | Frontiers in nutrition | OpenAlex; PubMed | nan |
| PMID:35287333.0 | Long-Term COVID 19 Sequelae in Adolescents: the Overlap with Orthostatic Intolerance and ME/CFS. | 2022 | Current pediatrics reports | Europe PMC; PubMed | nan |
| PMID:35421511.0 | The underlying sex differences in neuroendocrine adaptations relevant to Myalgic Encephalomyelitis Chronic Fatigue Syndrome. | 2022 | Frontiers in neuroendocrinology | Europe PMC; PubMed | nan |
| PMID:35433768.0 | Diagnosis of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome With Partial Least Squares Discriminant Analysis: Relevance of Blood Extracellular Vesicles. | 2022 | Frontiers in medicine | Europe PMC; PubMed | nan |
| PMID:35526605.0 | Neurovascular Dysregulation and Acute Exercise Intolerance in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Randomized, Placebo-Controlled Trial of Pyridostigmine. | 2022 | Chest | Europe PMC; PubMed | NCT03674541; NCT07454395 |
| PMID:35535102.0 | Fatigue in Cirrhosis. | 2022 | Journal of clinical and experimental hepatology | PubMed | nan |
| PMID:35589660.0 | [Patients with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) Who Have Already Visited Some Medical Institutions: Diagnosis, Treatment and Research]. | 2022 | Brain and nerve = Shinkei kenkyu no shinpo | Europe PMC; PubMed | nan |
| PMID:35854226.0 | DecodeME: community recruitment for a large genetics study of myalgic encephalomyelitis / chronic fatigue syndrome. | 2022 | BMC neurology | Europe PMC; OpenAlex; PubMed | nan |
| PMID:35870963.0 | Orthostatic intolerance as a potential contributor to prolonged fatigue and inconsistent performance in elite swimmers. | 2022 | BMC sports science, medicine & rehabilitation | PubMed | nan |
| PMID:35893858.0 | Use of 1-MNA to Improve Exercise Tolerance and Fatigue in Patients after COVID-19. | 2022 | Nutrients | PubMed | nan |
| PMID:35925074.0 | [Post-COVID syndrome with fatigue and exercise intolerance: myalgic encephalomyelitis/chronic fatigue syndrome]. | 2022 | Innere Medizin (Heidelberg, Germany) | Europe PMC; PubMed | nan |
| PMID:36169159.0 | Multi-disciplinary collaborative consensus guidance statement on the assessment and treatment of postacute sequelae of SARS-CoV-2 infection (PASC) in children and adolescents. | 2022 | PM & R : the journal of injury, function, and rehabilitation | OpenAlex; PubMed | nan |
| PMID:36461167.0 | Effect of using a structured pacing protocol on post-exertional symptom exacerbation and health status in a longitudinal cohort with the post-COVID-19 syndrome. | 2023 | Journal of medical virology | OpenAlex; PubMed | nan |
| PMID:36553962.0 | What Primary Care Practitioners Need to Know about the New NICE Guideline for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome in Adults. | 2022 | Healthcare (Basel, Switzerland) | Europe PMC; Preprint (medRxiv/bioRxiv); PubMed | nan |
| PMID:36632532.0 | Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (CFS/ME) in Adolescents: Practical Guidance and Management Challenges. | 2023 | Adolescent health, medicine and therapeutics | Europe PMC; PubMed | nan |
| PMID:36648876.0 | The Draft Report by the Institute for Quality and Efficiency in Healthcare Does Not Provide Any Evidence That Graded Exercise Therapy and Cognitive Behavioral Therapy Are Safe and Effective Treatments for Myalgic Encepha | 2023 | Diseases (Basel, Switzerland) | Europe PMC; PubMed | nan |
| PMID:36698810.0 | Improvement of Long COVID symptoms over one year. | 2022 | Frontiers in medicine | Europe PMC; PubMed | nan |
| PMID:36765375.0 | Symptom-based clusters in people with ME/CFS: an illustration of clinical variety in a cross-sectional cohort. | 2023 | Journal of translational medicine | Europe PMC; PubMed | nan |
| PMID:36769022.0 | Stress-Induced Transcriptomic Changes in Females with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Reveal Disrupted Immune Signatures. | 2023 | International journal of molecular sciences | Europe PMC; PubMed | nan |
| PMID:36911961.0 | My experience with ME/CFS and implications: A personal narrative. | 2023 | Work (Reading, Mass.) | Europe PMC; PubMed | nan |
| PMID:36947108.0 | Pathogenic mechanisms of post-acute sequelae of SARS-CoV-2 infection (PASC). | 2023 | eLife | Europe PMC; PubMed | NCT05874089; NCT06940609 |
| PMID:37054777.0 | Exercise Pathophysiology in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome and Postacute Sequelae of SARS-CoV-2: More in Common Than Not? | 2023 | Chest | Europe PMC; PubMed | nan |
| PMID:37109676.0 | The Role of Psychotherapy in the Care of Patients with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome. | 2023 | Medicina (Kaunas, Lithuania) | Europe PMC; OpenAlex; PubMed | nan |
| PMID:37114822.0 | Do diagnostic criteria for ME matter to patient experience with services and interventions? Key results from an online RDS survey targeting fatigue patients in Norway. | 2023 | Journal of health psychology | PubMed | nan |
| PMID:37255930.0 | Achieving symptom relief in patients with myalgic encephalomyelitis by targeting the neuro-immune interface and optimizing disease tolerance. | 2023 | Oxford open immunology | PubMed | nan |
| PMID:37419535.0 | Fatigue in Post-Acute Sequelae of Coronavirus Disease 2019. | 2023 | Physical medicine and rehabilitation clinics of North America | PubMed | nan |
| PMID:37525488.0 | Applying Lessons From Rheumatology to Better Understand Long COVID. | 2024 | Arthritis care & research | Europe PMC; PubMed | nan |
| PMID:37693468.0 | Dysregulation of extracellular vesicle protein cargo in female ME/CFS cases and sedentary controls in response to maximal exercise. | 2023 | bioRxiv : the preprint server for biology | Preprint (medRxiv/bioRxiv); PubMed | nan |
| PMID:37864020.0 | [Interdisciplinary multimodal pain therapy in postviral syndromes and ME/CFS : Features, pitfalls and model concept]. | 2024 | Schmerz (Berlin, Germany) | PubMed | nan |
| PMID:37881452.0 | Typing myalgic encephalomyelitis by infection at onset: A DecodeME study. | 2023 | NIHR open research | Europe PMC; Preprint (medRxiv/bioRxiv); PubMed | nan |
| PMID:38044956.0 | Pediatric Post-Acute Sequelae of SARS-CoV-2 Infection. | 2023 | Fatigue : biomedicine, health & behavior | Europe PMC; PubMed | nan |
| PMID:38107643.0 | Focus on post-exertional malaise when approaching ME/CFS in specialist healthcare improves satisfaction and reduces deterioration. | 2023 | Frontiers in neurology | Europe PMC; OpenAlex; PubMed | nan |
| PMID:38173127.0 | Dysregulation of extracellular vesicle protein cargo in female myalgic encephalomyelitis/chronic fatigue syndrome cases and sedentary controls in response to maximal exercise. | 2024 | Journal of extracellular vesicles | Europe PMC; OpenAlex; PubMed | nan |
| PMID:38202282.0 | Immunological Patient Stratification in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome. | 2024 | Journal of clinical medicine | Europe PMC; Preprint (medRxiv/bioRxiv); PubMed | nan |
| PMID:38279014.0 | Long COVID in pediatrics-epidemiology, diagnosis, and management. | 2024 | European journal of pediatrics | Europe PMC; PubMed | nan |
| PMID:38282368.0 | Psychometric evaluation of the DePaul Symptom Questionnaire-Short Form (DSQ-SF) among adults with Long COVID, ME/CFS, and healthy controls: A machine learning approach. | 2024 | Journal of health psychology | Europe PMC; PubMed | nan |
| PMID:38447497.0 | Efficacy of aquatic vs land-based therapy for pain management in women with fibromyalgia: a randomised controlled trial. | 2024 | Physiotherapy | OpenAlex; PubMed | nan |
| PMID:38540980.0 | The Head-Up Tilt Table Test as a Measure of Autonomic Functioning among Patients with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome. | 2024 | Journal of personalized medicine | Europe PMC; PubMed | nan |
| PMID:38630952.0 | Case-Control Study of Individuals With Small Fiber Neuropathy After COVID-19. | 2024 | Neurology(R) neuroimmunology & neuroinflammation | Europe PMC; PubMed | nan |
| PMID:38736736.0 | Videoconference-delivered group Cognitive Behavioral Stress Management for ME/CFS patients who present with severe PEM: A randomized controlled trial. | 2024 | Fatigue : biomedicine, health & behavior | Europe PMC; OpenAlex; PubMed | nan |
| PMID:38743348.0 | [Interdisciplinary, collaborative D-A-CH (Germany, Austria and Switzerland) consensus statement concerning the diagnostic and treatment of myalgic encephalomyelitis/chronic fatigue syndrome]. | 2024 | Wiener klinische Wochenschrift | Europe PMC; PubMed | nan |
| PMID:40627396.0 | Oxidative stress is a shared characteristic of ME/CFS and Long COVID. | 2025 | Proceedings of the National Academy of Sciences of the United States of America | Europe PMC; Preprint (medRxiv/bioRxiv); PubMed | nan |
| NCT ID | Title | Status | Phase | Sponsor | Intervention |
|---|---|---|---|---|---|
| NCT06978582 | Effectiveness and Safety of a Tele-rehabilitation Program Based on Mindful and Conscious Movement-based Exercise vs Conventional Low-intensity Exercise on Fatigue and Related Varia | ACTIVE_NOT_RECRUITING | nan | University of Seville | Mindful and conscious movement-based exercise; Conventional exercise |
| NCT06655844 | Extended Home-use Trial of a Novel Device to Reduce Chronic Pain | RECRUITING | nan | Icahn School of Medicine at Mount Sinai | Sana Pain Reliever; Sham SPR |
| NCT07454395 | Investigating the Effect of Swimming on Autonomic and Symptomatic Responses in Individuals With Myalgic Encephalomyelitis/Chronic Fatigue Syndrome | SUSPENDED | nan | Simon Fraser University | Swimming; Cycling |
| ID | Title | Year | Journal | Source | Linked NCTs |
|---|---|---|---|---|---|
| DOI | Post-COVID Postural Orthostatic Tachycardia Syndrome and Inappropriate Sinus Tachycardia in the Pediatric Population | 2024 | Current Clinical Microbiology Reports | OpenAlex | nan |
| NCT ID | Title | Status | Phase | Sponsor | Intervention |
|---|---|---|---|---|---|
| NCT04705831 | A Randomized, Double Blind, Placebo Controlled, Cross-Over, Proof-of-Concept Study to Evaluate the Benefit of RUCONEST (C1 Esterase Inhibitor [Recombinant]) in Improving Neurologic | COMPLETED | PHASE2 | IMMUNOe Research Centers | Ruconest |
| NCT04961190 | A Comparison of Prolonged Exposure Therapy, Pharmacotherapy, and Their Combination for PTSD: What Works Best, and for Whom | ACTIVE_NOT_RECRUITING | PHASE4 | University of Pennsylvania | Prolonged Exposure Therapy; Pharmacotherapy with paroxetine or venlafaxine XR |
| NCT05760092 | The Use of Photobiomodulation in the Treatment of Oral Complaints of Long COVID-19. A Randomized Controlled Trial. | COMPLETED | PHASE2 | University of Nove de Julho | Institutional standard treatment for xerostomia and Long Covid; Photobiomodulation Therapy; Placebo Photobiomodulation Therapy |
| NCT06631287 | Randomized Double-Blind Placebo-Controlled Trial EValuating Baricitinib on PERSistent NEurologic and Cardiopulmonary Symptoms of Long COVID (REVERSE-LC) | RECRUITING | PHASE3 | Wes Ely | Baricitinib; Placebo |
| NCT05305105 | Effects of Psilocybin in Post-Treatment Lyme Disease | COMPLETED | PHASE1 | Johns Hopkins University | Psilocybin |
| NCT06511050 | Investigating the Effects of Lumbrokinase in Adults With Long Covid, Post-treatment Lyme Disease Syndrome, and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome | RECRUITING | PHASE1; PHASE2 | Icahn School of Medicine at Mount Sinai | Lumbrokinase |
| NCT05219929 | T4 - Tetracycline Treatment Tolerability Trial A Pilot Study Examining the Feasibility and Tolerability of Tetracycline Therapy in Post-Treatment Lyme Disease (PTLD) | ENROLLING_BY_INVITATION | PHASE2 | Johns Hopkins University | Tetracycline 500 Mg; Placebo |
| NCT06978582 | Effectiveness and Safety of a Tele-rehabilitation Program Based on Mindful and Conscious Movement-based Exercise vs Conventional Low-intensity Exercise on Fatigue and Related Varia | ACTIVE_NOT_RECRUITING | nan | University of Seville | Mindful and conscious movement-based exercise; Conventional exercise |
| NCT06655844 | Extended Home-use Trial of a Novel Device to Reduce Chronic Pain | RECRUITING | nan | Icahn School of Medicine at Mount Sinai | Sana Pain Reliever; Sham SPR |
| NCT06611111 | Phase 1, Randomized, Double-Blind, Placebo-Controlled Trial of Pulse Dosed Ceftriaxone for Post-Treatment Lyme Disease | RECRUITING | EARLY_PHASE1 | State University of New York - Upstate Medical University | Ceftriaxone (Rocephin®); Dextrose 5% (D5W) |
| NCT06915324 | Transcranial Direct Current Stimulation (tDCS) of Brain Fog in Patients With Post Treatment Lyme Disease | RECRUITING | nan | Columbia University | Transcranial Direct Current Stimulation (tDCS); Cognitive training |
| NCT06785402 | Phase 1/2, Randomized, Double-Blind, Placebo-Controlled Trial of Pulse Dosed Ceftriaxone for Post-Treatment Lyme Disease | WITHDRAWN | PHASE1; PHASE2 | Hackensack Meridian Health | Ceftriaxone treatment; Placebo |
| NCT05753228 | In Vivo Investigation on Mitochondrial Dysfunction in Post-COVID Fatigue and Cancer Fatigue. | UNKNOWN | nan | National University Hospital, Singapore | MRI/ 3D Arterial Spin Labelling (ASL) and 1H magnetic resonance spectroscopy (MRS); Chalder Fatigue Scale; Health Questionnaire (EQ-5D-5L); Hamilton Depression |
| NCT04349605 | Meditation and Yoga for Patients With Persistent Symptoms After Lyme Disease | WITHDRAWN | nan | Research Foundation for Mental Hygiene, Inc. | Meditation; Kundalini Yoga |
| ID | Title | Year | Journal | Source | Linked NCTs |
|---|---|---|---|---|---|
| PMID:33166287.0 | Persistent fatigue following SARS-CoV-2 infection is common and independent of severity of initial infection. | 2020 | PloS one | PubMed | nan |
| PMID:33789412.0 | Characterizing the Symptoms of Patients with Persistent Post-Treatment Lyme Symptoms: A Survey of Patients at a Lyme Disease Clinic in Rhode Island. | 2021 | Rhode Island medical journal (2013) | PubMed | nan |
| PMID:34582513.0 | Characterizing Post-treatment Lyme Disease Syndrome: A Mixed Methods Study of Patients at a Lyme Disease Clinic in Rhode Island. | 2021 | Rhode Island medical journal (2013) | Europe PMC; PubMed | nan |
| PMID:34939506.0 | Post-Covid-19 Syndrome: Improvements in Health-Related Quality of Life Following Psychology-Led Interdisciplinary Virtual Rehabilitation. | 2021 | Journal of primary care & community health | PubMed | nan |
| PMID:35298664.0 | [Persistent fatigue symptoms following COVID-19 infection in healthcare workers: risk factors and impact on quality of life]. | 2022 | Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz | PubMed | nan |
| PMID:36012033.0 | Application of an EMG-Rehabilitation Robot in Patients with Post-Coronavirus Fatigue Syndrome (COVID-19)-A Feasibility Study. | 2022 | International journal of environmental research and public health | Europe PMC; OpenAlex; PubMed | NCT05130736 |
| PMID:37233680.0 | Positive Effects of Probiotic Therapy in Patients with Post-Infectious Fatigue. | 2023 | Metabolites | Europe PMC; OpenAlex; PubMed | nan |
| PMID:38549668.0 | Impact of treatment adherence and inhalation technique on asthma outcomes of pediatric patients: a longitudinal study. | 2024 | Frontiers in pharmacology | Europe PMC; Preprint (medRxiv/bioRxiv); PubMed | nan |
| PMID:38870502.0 | Effectiveness of Comprehensive Nursing Intervention Based on the Roy Adaptation Model in the Perioperative Period of Bladder Cancer. | 2024 | Alternative therapies in health and medicine | Europe PMC; PubMed | nan |
| PMID:39407877.0 | How Long Is Long COVID? Evaluation of Long-Term Health Status in Individuals Discharged from a Specialist Community Long COVID Service. | 2024 | Journal of clinical medicine | Europe PMC; Preprint (medRxiv/bioRxiv); PubMed | nan |
| PMID:41089039.0 | Interdisciplinary collaborative care model combined with family empowerment in patients with comorbid hypertension and diabetes: A study on blood pressure/glucose control and psychosocial adaptation based on the COM-B mo | 2025 | Clinical and experimental hypertension (New York, N.Y. : 1993) | Europe PMC; PubMed | nan |
| PMID:41281561.0 | Does C1 esterase inhibitor play a role in post COVID-19 neurological symptoms? A randomized, double-blind, placebo-controlled, crossover, proof-of-concept study. | 2025 | Frontiers in neurology | Europe PMC; PubMed | NCT04705831 |
| PMID:41357843.0 | Peripheral Levels of Selected Biomarkers in Patients with Post-Sarcoidosis Chronic Fatigue Syndrome. | 2025 | Journal of inflammation research | PubMed | nan |
| PMID:41741501.0 | Pilot study of psilocybin in patients with post-treatment lyme disease. | 2026 | Scientific reports | Europe PMC; PubMed | NCT05305105 |
| PMID:41796643.0 | Feasibility and preliminary efficacy of an online yoga program for managing symptoms of post-treatment lyme disease syndrome. | 2026 | Complementary therapies in medicine | Europe PMC; PubMed | nan |
| NCT ID | Title | Status | Phase | Sponsor | Intervention |
|---|---|---|---|---|---|
| NCT05430152 | A Double Blind Randomized Trial of Low-dose Naltrexone for Post-COVID Fatigue Syndrome | COMPLETED | PHASE2 | Luis Nacul | Low-Dose Naltrexone; Placebo |
| NCT07280572 | RECLAIM: an Adaptive Platform Trial for the Evaluation of Treatments for Post-Acute Sequelae of SARS-CoV-2 Infection (PASC) | ENROLLING_BY_INVITATION | PHASE3 | Janneke van de Wijgert | Metformin; colchicine |
| NCT05664711 | Effect of Stellate Ganglion Block on ME/CFS Symptoms and Metabolites | COMPLETED | PHASE1 | Neuroversion, Inc. | Bupivacaine Injection |
| NCT04741841 | Effect of Probiotic Food Supplement "GutMagnific™" in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS), Also Known as Post-viral Fatigue Syndrome, and Comorbid | COMPLETED | nan | ImmuneBiotech Medical Sweden AB | GutMagnific™ H.; GutMagnific™ L.; Placebo |
| NCT06631287 | Randomized Double-Blind Placebo-Controlled Trial EValuating Baricitinib on PERSistent NEurologic and Cardiopulmonary Symptoms of Long COVID (REVERSE-LC) | RECRUITING | PHASE3 | Wes Ely | Baricitinib; Placebo |
| NCT06511050 | Investigating the Effects of Lumbrokinase in Adults With Long Covid, Post-treatment Lyme Disease Syndrome, and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome | RECRUITING | PHASE1; PHASE2 | Icahn School of Medicine at Mount Sinai | Lumbrokinase |
| NCT06992414 | Exploring Creatine Supplementation for Improved Exercise Capacity and Reduced Fatigue in Long COVID-19: A Randomized Controlled Trial | NOT_YET_RECRUITING | nan | University of Calgary | Creatine monohydrate |
| NCT07454395 | Investigating the Effect of Swimming on Autonomic and Symptomatic Responses in Individuals With Myalgic Encephalomyelitis/Chronic Fatigue Syndrome | SUSPENDED | nan | Simon Fraser University | Swimming; Cycling |
| NCT05753228 | In Vivo Investigation on Mitochondrial Dysfunction in Post-COVID Fatigue and Cancer Fatigue. | UNKNOWN | nan | National University Hospital, Singapore | MRI/ 3D Arterial Spin Labelling (ASL) and 1H magnetic resonance spectroscopy (MRS); Chalder Fatigue Scale; Health Questionnaire (EQ-5D-5L); Hamilton Depression |
| ID | Title | Year | Journal | Source | Linked NCTs |
|---|---|---|---|---|---|
| PMID:36911961.0 | My experience with ME/CFS and implications: A personal narrative. | 2023 | Work (Reading, Mass.) | Europe PMC; PubMed | nan |
| PMID:37398713.0 | Mechanisms and Severity of Exercise Intolerance Following COVID-19 and Similar Viral Infections: A Comparative Review. | 2023 | Cureus | Europe PMC; PubMed | nan |
| PMID:37881452.0 | Typing myalgic encephalomyelitis by infection at onset: A DecodeME study. | 2023 | NIHR open research | Europe PMC; Preprint (medRxiv/bioRxiv); PubMed | nan |
| PMID:38202282.0 | Immunological Patient Stratification in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome. | 2024 | Journal of clinical medicine | Europe PMC; Preprint (medRxiv/bioRxiv); PubMed | nan |
| PMID:38279014.0 | Long COVID in pediatrics-epidemiology, diagnosis, and management. | 2024 | European journal of pediatrics | Europe PMC; PubMed | nan |
| PMID:38684388.0 | Eight-Week Creatine-Glucose Supplementation Alleviates Clinical Features of Long COVID. | 2024 | Journal of nutritional science and vitaminology | Europe PMC; OpenAlex; PubMed | nan |
| PMID:40397936.0 | Multimodal Web-Based Telerehabilitation for Patients With Post-COVID-19 Condition: Protocol for a Randomized Controlled Trial. | 2025 | JMIR research protocols | Europe PMC; OpenAlex; PubMed | nan |
| PMID:41013344.0 | Medical complexity and healthcare utilization among patients attending three U.S. post-COVID clinics. | 2025 | BMC infectious diseases | Europe PMC; PubMed | nan |
| PMID:41506643.0 | Intelligent Breathing Training Using a Digital Device for Postoperative Lung Cancer Patients: A Randomized Controlled Trial. | 2026 | Biological research for nursing | Europe PMC; PubMed | nan |
| PMID:41930109.0 | Molecular hydrogen as a treatment for ME/CFS: a mini-review of clinical evidence and mechanistic rationale. | 2026 | Frontiers in medicine | Europe PMC; PubMed | nan |
| PMID:42141452.0 | Chronic fatigue syndrome in nursing practice: a concept analysis. | 2026 | BMC nursing | Europe PMC; PubMed | nan |
| PMID:40372110.0 | Gastrointestinal Barrier Disruption in Post-COVID Syndrome Fatigue Patients. | 2025 | nan | Europe PMC; Preprint (medRxiv/bioRxiv) | nan |
| PMID:38605969.0 | The gastrointestinal microbiota in the development of ME/CFS: a critical view and potential perspectives | 2024 | Frontiers in Immunology | OpenAlex | nan |
| NCT ID | Title | Status | Phase | Sponsor | Intervention |
|---|---|---|---|---|---|
| NCT04997395 | Safety and Tolerability of Full Spectrum Cannabidiol Dominant Medicinal Cannabis in Treating Symptoms Associated With Long COVID: A Feasibility Study | COMPLETED | PHASE2 | Bod Australia | MediCabilis Cannabis sativa 50 |
| NCT06305793 | RECOVER-AUTONOMIC (IVIG): Randomized Trial of the Effect of IVIG Versus Placebo on Long COVID Symptoms | ACTIVE_NOT_RECRUITING | PHASE2 | Kanecia Obie Zimmerman | IVIG (intravenous immunoglobulin); IVIG Placebo; Coordinated Care; Usual Care |
| NCT06296914 | Developing and Testing a Mobile Health System for Patients with Postural Orthostatic Tachycardia Syndrome (POTS) | COMPLETED | nan | Jami Warren | POTSapp; Waitlist Control |
| NCT05043051 | Autoimmune Basis for Postural Tachycardia Syndrome | ACTIVE_NOT_RECRUITING | nan | University of Oklahoma | Vagal stimulation; Sham stimulation |
| NCT06073886 | Personalized Circuit-Based Frontoamygdala Neuromodulation for Persistent Post-Concussive Symptoms | RECRUITING | PHASE2 | University of California, Los Angeles | Active cTBS; Inactive/Sham cTBS; Imaginal exposure |
| NCT04186286 | A Randomized Crossover Study of Propranolol Versus Ivabradine in Postural Tachycardia Syndrome (POTS) | RECRUITING | PHASE2 | University of Calgary | Ivabradine 4-week course; Propranolol 4-week course; Placebo 4-week course |
| NCT05445830 | Physiological Characterization of Functional Limitations and Exercise Intolerance in Post-COVID Patients | ACTIVE_NOT_RECRUITING | nan | Karolinska Institutet | High-Intensity-Interval-Exercise; Moderate-Intensity-Continuous-Exercise; Strength training; Baseline assessment; 1 year follow-up |
| NCT07455994 | Dysautonomia in Children With Type 1 Diabetes: "DysDiab" Single-center Study | RECRUITING | nan | Centre Hospitalier Universitaire de Saint Etienne | Neurocoach® and Sudoscan® |
| NCT06554834 | Effects of Three Therapeutic Sessions of the Fourth Ventricle Compression Technique and Rib Raising Osteopathic Technique on Autonomic Nervous System Activity Measured by Heart Rat | RECRUITING | nan | SomaticMed | CV4 + RR; CV4; sham ultrasound transducer; Ultrasound Transducer Sham Procedure; EEG/HRV/RSA (Electroencephalography, Heart Rate Variability, Respiratory Sinus |
| NCT05400174 | Effects of Blood Pressure on Cognition and Cerebral Blood Flow in Parkinson Disease | RECRUITING | nan | University of California, San Diego | Tilt table (upright position) |
| NCT07278206 | Mitigating Cognitive Problems and Fatigue With Brain Stimulation in Long COVID | RECRUITING | nan | Amsterdam UMC, location VUmc | Repetitive Transcranial Magnetic Stimulation; Sham device |
| NCT07110714 | Effects of Kneipp Hydrotherapy in Post-COVID-19 Patients: A Randomized Controlled Trial | RECRUITING | nan | Eggensberger OHG | Cold water hydrotherapy |
| NCT05741112 | The Long COVID-19 Wearable Device Study | RECRUITING | nan | Scripps Translational Science Institute | Wearable device |
| NCT07013903 | Effects of Kneipp Hydrotherapy During Inpatient Post-Covid-19 Rehabilitation: A Randomized Controlled Trial | RECRUITING | nan | Schön Klinik Berchtesgadener Land | Standard rehabilitation plus cold water hydrotherapy; Standard rehabilitation only |
| NCT05481177 | Comparative Cohort Study of Post-acute COVID-19 Infection With a Nested, Randomized Controlled Trial of Ivabradine for Those With Postural Orthostatic Tachycardia Syndrome. | UNKNOWN | PHASE4 | Uniformed Services University of the Health Sciences | Ivabradine |
| NCT07388550 | Phase I Open-Label Safety Trial of Pembrolizumab for Neurological Post-Acute Sequelae of SARS-CoV-2 (PD1-PASC I) | NOT_YET_RECRUITING | PHASE1 | National Institute of Neurological Disorders and Stroke (NINDS) | Keytruda |
| NCT06996314 | Effects of Transcutaneous Auricular Vagus Nerve Stimulation Combined With Slow-Paced Diaphragmatic Breathing on Postural Tachycardia Syndrome: A Randomized Controlled Trial | NOT_YET_RECRUITING | nan | Ali Kapan | TVNS + Slow-Paced Breathing (TVNS+SDB); TVNS without Breathing Training (TVNS+NB); Sham TVNS + SDB; Sham TVNS + NB |
| NCT05796154 | Hemodynamic Biomarkers for Postural Tachycardia Syndrome Using a Novel Continuous Beat-to-Beat Wearable Blood Pressure Monitor | NOT_YET_RECRUITING | nan | University of Calgary | ear blood pressure monitor |
| NCT06953661 | Ultrasound Guided Stellate Ganglion Block in Postural Tachycardia Syndrome: A Randomized Double Blind Sham Placebo-controlled Pilot Study | NOT_YET_RECRUITING | nan | Stanford University | Stellate ganglion block; Sham injection of saline; Ropivacaine; Normal saline |
| NCT05618067 | The Impact of Improved Vagal Function on Periaqueductal Gray Connectivity | NOT_YET_RECRUITING | nan | Virginia Commonwealth University | breathing exercise training |
| NCT07454395 | Investigating the Effect of Swimming on Autonomic and Symptomatic Responses in Individuals With Myalgic Encephalomyelitis/Chronic Fatigue Syndrome | SUSPENDED | nan | Simon Fraser University | Swimming; Cycling |
| NCT05228665 | HEART Rate Variability Biofeedback in LOng COVID-19 (HEARTLOC) | UNKNOWN | nan | University of Leeds | Heart Rate Variability Biofeedback (HRV-B) |
| NCT05629793 | Differential Diagnosis of Persistent COVID-19 by Artificial Intelligence | UNKNOWN | nan | Fundacin Biomedica Galicia Sur | Experimental tests |
| NCT05454683 | Effect of Melatonin Plus Zinc Supplementation on Fatigue, Pain, Sleep Disturbances, Anxiety and Depression, and Autonomic Dysfunction in ME/CFS: a Randomized, Double-blind, Placebo | UNKNOWN | nan | Laboratorios Viñas, S.A. | melatonin plus zinc; isomaltose and magnesium stearate |
| NCT05851846 | Amygdala Insula Retraining in the Management of Long COVID Symptoms | UNKNOWN | nan | Miami VA Healthcare System | Amygdala insula retraining |
| ID | Title | Year | Journal | Source | Linked NCTs |
|---|---|---|---|---|---|
| PMID:32080891.0 | Tossing and Turning in Bed: Nocturnal Movements in Parkinson's Disease. | 2020 | Movement disorders : official journal of the Movement Disorder Society | PubMed | nan |
| PMID:32358461.0 | Heart Rate Variability Analysis: A Useful Tool to Assess Poststroke Cardiac Dysautonomia. | 2020 | The neurologist | PubMed | nan |
| PMID:32981583.0 | Autonomic Rehabilitation: Adapting to Change. | 2020 | Physical medicine and rehabilitation clinics of North America | PubMed | nan |
| PMID:33024503.0 | Defining Cardiac Dysautonomia - Different Types, Overlap Syndromes; Case-based Presentations. | 2020 | Journal of atrial fibrillation | Europe PMC; PubMed | nan |
| PMID:33400783.0 | Long-Term Influence of Concussion on Cardio-Autonomic Function in Adolescent Hockey Players. | 2021 | Journal of athletic training | PubMed | nan |
| PMID:33417078.0 | Chemotherapy and Radiation-Associated Cardiac Autonomic Dysfunction. | 2021 | Current oncology reports | PubMed | nan |
| PMID:33862302.0 | Emotional Behavioural and Autonomic Dysregulation (EBAD) in Rett Syndrome - EDA and HRV monitoring using wearable sensor technology. | 2021 | Journal of psychiatric research | PubMed | nan |
| PMID:34948285.0 | Cardiac Changes in Parkinson's Disease: Lessons from Clinical and Experimental Evidence. | 2021 | International journal of molecular sciences | PubMed | nan |
| PMID:34975538.0 | Central Hypovolemia Detection During Environmental Stress-A Role for Artificial Intelligence? | 2021 | Frontiers in physiology | PubMed | nan |
| PMID:35171410.0 | Cardiovascular Autonomic Regulation, ETCO2 and the Heart Rate Response to the Tilt Table Test in Patients with Orthostatic Intolerance. | 2022 | Applied psychophysiology and biofeedback | PubMed | nan |
| PMID:35394733.0 | [Current concepts about autonomic dysfunction in patients with epilepsy]. | 2022 | Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova | PubMed | nan |
| PMID:35632776.0 | Impaired Vagal Activity in Long-COVID-19 Patients. | 2022 | Viruses | PubMed | nan |
| PMID:36151442.0 | Coexistence of fibromyalgia syndrome and inflammatory rheumatic diseases, and autonomic cardiovascular system involvement in fibromyalgia syndrome. | 2023 | Clinical rheumatology | PubMed | nan |
| PMID:36298551.0 | Dysautonomia in Children with Post-Acute Sequelae of Coronavirus 2019 Disease and/or Vaccination. | 2022 | Vaccines | Europe PMC; PubMed | nan |
| PMID:36352579.0 | Cardiovascular Autonomic Assessment in Guillain-Barré Syndrome: A Longitudinal Study. | 2022 | Neurology India | PubMed | nan |
| PMID:36371084.0 | Autonomic nerve regulation in joint hypermobility patients with myofascial trigger points by Musculoskeletal Interfiber Counterirritant Stimulation (MICS). | 2022 | Medical engineering & physics | PubMed | nan |
| PMID:36410797.0 | HEART rate variability biofeedback for long COVID symptoms (HEARTLOC): protocol for a feasibility study. | 2022 | BMJ open | Europe PMC; Preprint (medRxiv/bioRxiv); PubMed | NCT05228665 |
| PMID:36639565.0 | Heart rate variability responses to cognitive stress in fibromyalgia are characterised by inadequate autonomous system stress responses: a clinical trial. | 2023 | Scientific reports | Europe PMC; PubMed | nan |
| PMID:36832445.0 | Therapeutic Approaches to Dysautonomia in Childhood, with a Special Focus on Long COVID. | 2023 | Children (Basel, Switzerland) | Europe PMC; OpenAlex; PubMed | nan |
| PMID:36873318.0 | Low-level tragus stimulation improves autoantibody-induced hyperadrenergic postural tachycardia syndrome in rabbits. | 2023 | Heart rhythm O2 | Europe PMC; OpenAlex; PubMed | nan |
| PMID:37143130.0 | Clinical surrogates of dysautonomia predict lethal outcome in COVID-19 on intensive care unit. | 2023 | Neurological research and practice | Europe PMC; PubMed | nan |
| PMID:37469536.0 | Ivabradine effects on COVID-19-associated postural orthostatic tachycardia syndrome: a single center prospective study. | 2023 | American journal of cardiovascular disease | Europe PMC; PubMed | nan |
| PMID:37508589.0 | Predicting Therapeutic Efficacy of Pharmacological Treatments in Children with Postural Orthostatic Tachycardia Syndrome: A Mini-Review. | 2023 | Children (Basel, Switzerland) | Europe PMC; PubMed | nan |
| PMID:37705568.0 | The Effect of Epipharyngeal Abrasive Therapy (EAT) on the Baroreceptor Reflex (BR). | 2023 | Cureus | Europe PMC; PubMed | nan |
| PMID:37795885.0 | An Obstructive Sleep Apnea - A Novel Public Health Threat. | 2023 | Physiological research | PubMed | nan |
| PMID:37947962.0 | Autonomic Manifestations of Long-COVID Syndrome. | 2023 | Current neurology and neuroscience reports | PubMed | nan |
| PMID:37999672.0 | Noninvasive Vagus Nerve Stimulation in Postural Tachycardia Syndrome: A Randomized Clinical Trial. | 2024 | JACC. Clinical electrophysiology | Europe PMC; PubMed | NCT05043051 |
| PMID:38260095.0 | Comparisons of heart rate variability responses to head-up tilt with and without abdominal and lower-extremity compression in healthy young individuals: a randomized crossover study. | 2023 | Frontiers in physiology | PubMed | nan |
| PMID:38298551.0 | HEART Rate Variability Biofeedback for LOng COVID Dysautonomia (HEARTLOC): Results of a Feasibility Study. | 2024 | Advances in rehabilitation science and practice | Europe PMC; PubMed | NCT05228665 |
| PMID:38458016.0 | An open trial of biofeedback for long COVID. | 2024 | Journal of psychosomatic research | PubMed | nan |
| PMID:38992427.0 | Moderately intense physical exercise alleviates electrocardiographic changes induced by cisplatin in rats. | 2024 | Revista portuguesa de cardiologia : orgao oficial da Sociedade Portuguesa de Cardiologia = Portugues | Europe PMC; PubMed | nan |
| PMID:39106427.0 | Clinical and Immunologic Effects of Paraprobiotics in Long-COVID Patients: A Pilot Study. | 2024 | Neurology(R) neuroimmunology & neuroinflammation | OpenAlex; PubMed | nan |
| PMID:39444156.0 | Autonomic rehabilitation: Vagal and sympathetic impacts of modified occipitomastoid suture V-spread. | 2025 | PM & R : the journal of injury, function, and rehabilitation | Europe PMC; PubMed | nan |
| PMID:39690561.0 | [The role of drug Cytoflavin in the correction of dysautonomia in patients with post-COVID syndrome]. | 2024 | Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova | Europe PMC; PubMed | nan |
| PMID:39841332.0 | Attenuated cardiac autonomic function in patients with long-COVID with impaired orthostatic hemodynamics. | 2025 | Clinical autonomic research : official journal of the Clinical Autonomic Research Society | Europe PMC; PubMed | nan |
| PMID:39867076.0 | Screening Female Patients With Autonomic Nervous System Imbalance Using the Toho Medical Index Before Tooth Extraction. | 2024 | Cureus | Europe PMC; PubMed | nan |
| PMID:39895557.0 | Cerebral Blood Flow in Orthostatic Intolerance. | 2025 | Journal of the American Heart Association | Europe PMC; PubMed | nan |
| PMID:40014480.0 | Tragus Nerve Stimulation Attenuates Postural Orthostatic Tachycardia Syndrome in Post COVID-19 Infection. | 2025 | Clinical cardiology | Europe PMC; OpenAlex; PubMed | nan |
| PMID:40426680.0 | Superficial Neuromodulation in Dysautonomia in Women with Post-COVID-19 Condition: A Pilot Study. | 2025 | Brain sciences | Europe PMC; OpenAlex; PubMed | nan |
| PMID:40502271.0 | Feasibility Assessment of a Wearable App to Manage Symptoms of Postural Orthostatic Tachycardia Syndrome Using Real-Time Heart Rate Monitoring. | 2025 | AMIA Joint Summits on Translational Science proceedings. AMIA Joint Summits on Translational Science | Europe PMC; PubMed | nan |
| PMID:40571949.0 | Sex-differences in autonomic and cardiovascular responses to multimodal therapy in Parkinson's disease: a pilot study. | 2025 | BMC neurology | PubMed | nan |
| PMID:40776209.0 | A Co-Designed and Theory-Based Mobile Health App for Patients with Postural Orthostatic Tachycardia Syndrome (POTS): Development and Usability Testing. | 2025 | Studies in health technology and informatics | Europe PMC; PubMed | nan |
| PMID:40869705.0 | Implementation of a Hybrid Cardiac Rehabilitation and Symptom Scoring System in Patients with Inappropriate or Postural Sinus Tachycardia Referred for Sinus Node Sparing Hybrid Ablation. | 2025 | Journal of clinical medicine | Europe PMC; PubMed | nan |
| PMID:40937377.0 | Recovery pulse rate and cardiovascular function indices in young female adults following orthostasis. | 2025 | Journal of biological methods | Europe PMC; PubMed | nan |
| PMID:40943825.0 | Acute Effects of Osteopathic Treatment in Long COVID-19 Patients with Fatigue Symptoms: A Randomized, Controlled Trial. | 2025 | Journal of clinical medicine | Europe PMC; OpenAlex; PubMed | nan |
| PMID:40962545.0 | [The predictive value of very low frequency power for the efficacy of vitamin D treatment in children with postural orthostatic tachycardia syndrome]. | 2025 | Zhonghua er ke za zhi = Chinese journal of pediatrics | Europe PMC; PubMed | nan |
| PMID:41132394.0 | Wearable technology in the management of complex chronic illness: preliminary survey results on self-reported outcomes. | 2025 | Frontiers in digital health | Europe PMC; PubMed | NCT07454395 |
| PMID:41142154.0 | Digital twin framework for postural tachycardia syndrome and autonomic disorders. | 2025 | Frontiers in neurology | Europe PMC; PubMed | nan |
| PMID:41483109.0 | A Portable, Active Abdominal Compression Binder for Orthostatic Intolerance: Design and Evaluation in Healthy Subjects. | 2026 | Annals of biomedical engineering | PubMed | nan |
| PMID:41720282.0 | Design and rationale of RECOVER-AUTONOMIC: A randomized platform trial evaluating interventions for Long COVID postural orthostatic tachycardia syndrome. | 2026 | American heart journal | Europe PMC; OpenAlex; PubMed | NCT06305780; NCT06305793; NCT06305806 |
| NCT ID | Title | Status | Phase | Sponsor | Intervention |
|---|---|---|---|---|---|
| NCT05629793 | Differential Diagnosis of Persistent COVID-19 by Artificial Intelligence | UNKNOWN | nan | Fundacin Biomedica Galicia Sur | Experimental tests |
| NCT ID | Title | Status | Phase | Sponsor | Intervention |
|---|---|---|---|---|---|
| NCT05633407 | A Phase 2 Randomized, Double-blinded, Placebo-controlled Study to Evaluate the Efficacy and Safety of Efgartigimod IV in Adult Patients With Post-COVID-19 Postural Orthostatic Tach | COMPLETED | PHASE2 | argenx | Efgartigimod; Placebo |
| NCT06133075 | Using Mirabegron to Increase Blood Pressure in Patients With Postural Orthostatic Tachycardia Syndrome | COMPLETED | PHASE2 | Cedars-Sinai Medical Center | Mirabegron 50 MG; Mirabegron 25 MG |
| NCT06268288 | Pilot Study--The Effects of Non-invasive Vagal Neurostimulation (nVNS) in Adolescents With Postural Orthostatic Tachycardia Syndrome (POTS) | COMPLETED | nan | Mayo Clinic | GammaCore intervention; STEPS management protocol |
| NCT06208163 | Psychoneuroimmunology as a Framework for Studying the Effects of Chiropractic Care in a Population With High Central Adiposity: a Pilot Trial | COMPLETED | nan | Life University | Chiropractic |
| NCT05946551 | Feasibility Assessment of a Decentralized Platform Adaptive Double-Blind, Randomized Controlled Trial Investigating Repurposed Drugs in the Treatment of Post-Acute Sequelae of Coro | TERMINATED | PHASE3 | Emory University | Cetirizine; Famotidine; Cetirizine Placebo; Famotidine Placebo |
| NCT05918978 | Open-Label Extension Study to Evaluate the Long-term Safety and Efficacy of Efgartigimod in Adult Patients With Post-COVID-19 Postural Orthostatic Tachycardia Syndrome (PC-POTS) Wh | TERMINATED | PHASE2 | argenx | Efgartigimod |
| NCT05823896 | An Interventional, Double-Blinded, 2-Arm Study to Investigate the Efficacy of Orally Administered Nirmatrelvir/Ritonavir Compared with Placebo/Ritonavir in Non-hospitalized Adult P | COMPLETED | PHASE2 | Karolinska Institutet | Nirmatrelvir/ritonavir; Placebo/ritonavir |
| NCT04842448 | Hyperbaric Oxygen for Treatment of Long COVID Syndrome; A Randomized, Placebo-Controlled, Double-Blind, Phase II Clinical Trial | COMPLETED | PHASE2 | Karolinska University Hospital | Hyperbaric oxygen; Sham treatment |
| NCT06305806 | RECOVER-AUTONOMIC (Ivabradine): Randomized Trial of the Effect of Ivabradine Versus Placebo on Long COVID Symptoms | COMPLETED | PHASE2 | Kanecia Obie Zimmerman | Ivabradine; Ivabradine Placebo; Coordinated Care; Usual Care |
| NCT05638620 | Evaluating the Effectiveness of Dual Sympathetic Blocks for Patients Experiencing Sympathetically-Mediated Symptoms From Post-Acute Sequelae of SARS-CoV-2 (PASC) | COMPLETED | PHASE1 | Jonathann Kuo, MD | stellate ganglion block with 0.5% bupivacaine |
| NCT04603157 | Remote Self-training Program for Patients With Postural Orthostatic Tachycardia Syndrome (POTS) | COMPLETED | nan | Mayo Clinic | Hybrid Exercise Training |
| NCT06305793 | RECOVER-AUTONOMIC (IVIG): Randomized Trial of the Effect of IVIG Versus Placebo on Long COVID Symptoms | ACTIVE_NOT_RECRUITING | PHASE2 | Kanecia Obie Zimmerman | IVIG (intravenous immunoglobulin); IVIG Placebo; Coordinated Care; Usual Care |
| NCT05454137 | Postural Orthostatic Tachycardia Syndrome: a Pilot, Feasibility Study of an Integrative Shared Medical Appointment Intervention | COMPLETED | nan | University of Arizona | Shared medical appointment |
| NCT05566379 | Effects of a Mindfulness Intervention on Physical and Psychological Well-Being and Quality of Life in Patients With Post Acute Sequelae of SARS-CoV-2 Infection (PASC) Dysautonomia | COMPLETED | nan | University of California, Los Angeles | Mindfulness - Mindful Awareness Practices ( MAPs) |
| NCT06503913 | Cognitive Muscular Therapy for Patients With Long-COVID (Post COVID-19) and Breathing Pattern Disorder | COMPLETED | nan | University of Salford | Cognitive Muscular Therapy; Breathing visualisation |
| NCT06172803 | RESToRE: Restoring Energy With Sub-symptom Threshold Optimized Rehabilitation Exercise for Long COVID | COMPLETED | nan | Columbia University | Restoring Energy with Sub-symptom Threshold Aerobic Rehabilitation Exercise; Light Stretching/Breathing Exercises |
| NCT04827992 | Evaluation of Medical Cannabis and Prescription Opioid Taper Support for Reduction of Pain and Opioid Dose in Patients With Chronic Non-Cancer Pain | COMPLETED | nan | Massachusetts General Hospital | Medical Marijuana; Prescription Opioid Taper Support (POTS) |
| NCT07182578 | Programming Aquatic Therapy for POTS | COMPLETED | nan | California State University, Dominguez Hills | Aquatic Occupational Therapy |
| NCT04919031 | Inspiratory Muscle Trainer Impact on Post Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) COVID-19 Hypertensive Patients With Long Term Persistent Symptoms | COMPLETED | nan | Cairo University | Inspiratory muscle trainer; diaphragmatic release |
| NCT05630040 | Vagus Nerve Simulation for Long-COVID-19 | COMPLETED | nan | Icahn School of Medicine at Mount Sinai | Non-invasive vagus nerve stimulation; Sham Intervention |
| NCT06974084 | A Multi-Center Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy of Maraviroc and Atorvastatin for the Treatment of Subjects With Long COVID/Post-Acute Se | NOT_YET_RECRUITING | PHASE2; PHASE3 | HealthBio, Inc. | Maraviroc (MVC); Atorvastatin, 10mg, 20mg, 40mg; Placebo, Maraviroc; Placebo, Atorvastatin |
| NCT05445830 | Physiological Characterization of Functional Limitations and Exercise Intolerance in Post-COVID Patients | ACTIVE_NOT_RECRUITING | nan | Karolinska Institutet | High-Intensity-Interval-Exercise; Moderate-Intensity-Continuous-Exercise; Strength training; Baseline assessment; 1 year follow-up |
| NCT06936319 | Physical Counterpressure Maneuvers in Postural Orthostatic Tachycardia Syndrome (POTS) - a Monocentric, Randomized Controlled Trial | RECRUITING | nan | Medical University Innsbruck | Best clinical practice plus CPM-biofeedback training; Best clinical practice |
| NCT07585513 | A Randomized Placebo-Controlled Clinical Trial Evaluating Mirabegron's Effectiveness in Alleviating POTS Symptoms | NOT_YET_RECRUITING | PHASE2 | Cedars-Sinai Medical Center | Mirabegron; Placebo |
| NCT05554107 | The Effect of Physical Activity on Postural Orthostatic Tachycardia Syndrome | RECRUITING | nan | Lund University | Training program |
| NCT05421208 | Cardiovascular Autonomic and Immune Mechanism of Post COVID-19 Tachycardia Syndrome | RECRUITING | nan | Vanderbilt University Medical Center | Levels of inflammatory cytokine ( IL-6) in post-COVID-19 POTS and controls; Levels of inflammatory cytokine ( IL-6) in controls; Effect on inflammation after ch |
| NCT07278206 | Mitigating Cognitive Problems and Fatigue With Brain Stimulation in Long COVID | RECRUITING | nan | Amsterdam UMC, location VUmc | Repetitive Transcranial Magnetic Stimulation; Sham device |
| NCT07110714 | Effects of Kneipp Hydrotherapy in Post-COVID-19 Patients: A Randomized Controlled Trial | RECRUITING | nan | Eggensberger OHG | Cold water hydrotherapy |
| NCT06147050 | Pilot Study of an Adaptive, Double-blind, Randomized, Placebo-controlled Study to Evaluate the Effect of Metformin in Reducing Fatigue in Long COVID Adolescent Patients With Chroni | UNKNOWN | PHASE3 | Purpose Life Sciences | Metformin; Placebo |
| NCT07013903 | Effects of Kneipp Hydrotherapy During Inpatient Post-Covid-19 Rehabilitation: A Randomized Controlled Trial | RECRUITING | nan | Schön Klinik Berchtesgadener Land | Standard rehabilitation plus cold water hydrotherapy; Standard rehabilitation only |
| NCT06027255 | Long COVID Immune Profiling | RECRUITING | nan | Vanderbilt University Medical Center | IL-6; cytokines (IL-17, and IFN-ɣ); Compass 31 |
| NCT06863207 | Autonomic Reactivity to Restore a Dysregulated Brain-Gut Axis Via Targeted Therapy | RECRUITING | nan | Medical College of Wisconsin | Percutaneous electrical nerve field stimulation; Hypnotherapy |
| NCT07388550 | Phase I Open-Label Safety Trial of Pembrolizumab for Neurological Post-Acute Sequelae of SARS-CoV-2 (PD1-PASC I) | NOT_YET_RECRUITING | PHASE1 | National Institute of Neurological Disorders and Stroke (NINDS) | Keytruda |
| NCT06996314 | Effects of Transcutaneous Auricular Vagus Nerve Stimulation Combined With Slow-Paced Diaphragmatic Breathing on Postural Tachycardia Syndrome: A Randomized Controlled Trial | NOT_YET_RECRUITING | nan | Ali Kapan | TVNS + Slow-Paced Breathing (TVNS+SDB); TVNS without Breathing Training (TVNS+NB); Sham TVNS + SDB; Sham TVNS + NB |
| NCT07409363 | A Randomised, Single-blind, Sham-controlled, Crossover Pilot Study Assessing the Effect of Non-invasive Vagus Nerve Stimulation (nVNS) on Autonomic Symptoms and Pain Management in | NOT_YET_RECRUITING | nan | University of Leeds | Active Vagus Nerve Stimulation; Subtherapeutic Stimulation (Sham Control) |
| NCT06953661 | Ultrasound Guided Stellate Ganglion Block in Postural Tachycardia Syndrome: A Randomized Double Blind Sham Placebo-controlled Pilot Study | NOT_YET_RECRUITING | nan | Stanford University | Stellate ganglion block; Sham injection of saline; Ropivacaine; Normal saline |
| NCT05618067 | The Impact of Improved Vagal Function on Periaqueductal Gray Connectivity | NOT_YET_RECRUITING | nan | Virginia Commonwealth University | breathing exercise training |
| NCT06672861 | Development and Validation of the Kansas City Cardiac Dysautonomia Questionnaire (KCDysQ) in Patients With Postural Orthostatic Tachycardia Syndrome, Inappropriate Sinus Tachycardi | NOT_YET_RECRUITING | nan | Kansas City Heart Rhythm Research Foundation | Kansas City Cardiac Dysautonomia Questionnaire (KCDysQ) |
| NCT05855356 | The Long-CoviD Patients Causal Diagnosis and Rehabilitation Randomized Feasibility Controlled Trial in Patients With Dysautonomia: the LoCoDiRe-Dys Study | UNKNOWN | nan | Evangelismos Hospital | Rehabilitation; Standard of Care |
| NCT05681455 | Physiotherapy for Persistent Function by Superficial Neuromodulation | UNKNOWN | nan | Universidad Rey Juan Carlos | Neuromodulation NESA NXSIGNAL® device |
| NCT05454683 | Effect of Melatonin Plus Zinc Supplementation on Fatigue, Pain, Sleep Disturbances, Anxiety and Depression, and Autonomic Dysfunction in ME/CFS: a Randomized, Double-blind, Placebo | UNKNOWN | nan | Laboratorios Viñas, S.A. | melatonin plus zinc; isomaltose and magnesium stearate |
| NCT04702217 | Physical Activity as a Complementary Treatment in Postural Orthostatic Tachycardia Syndrome - Evaluation of a Structured Physical Activity Program in Clinical Practice | WITHDRAWN | nan | Lund University | Training program |
| ID | Title | Year | Journal | Source | Linked NCTs |
|---|---|---|---|---|---|
| PMID:32411717.0 | Intravenous Cyclophosphamide in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome. An Open-Label Phase II Study. | 2020 | Frontiers in medicine | Europe PMC; OpenAlex; PubMed | nan |
| PMID:32764516.0 | Autonomic Phenotypes in Chronic Fatigue Syndrome (CFS) Are Associated with Illness Severity: A Cluster Analysis. | 2020 | Journal of clinical medicine | PubMed | nan |
| PMID:35171410.0 | Cardiovascular Autonomic Regulation, ETCO2 and the Heart Rate Response to the Tilt Table Test in Patients with Orthostatic Intolerance. | 2022 | Applied psychophysiology and biofeedback | PubMed | nan |
| PMID:35764245.0 | Engineered U1 snRNAs to modulate alternatively spliced exons. | 2022 | Methods (San Diego, Calif.) | PubMed | nan |
| PMID:36169159.0 | Multi-disciplinary collaborative consensus guidance statement on the assessment and treatment of postacute sequelae of SARS-CoV-2 infection (PASC) in children and adolescents. | 2022 | PM & R : the journal of injury, function, and rehabilitation | OpenAlex; PubMed | nan |
| PMID:36410797.0 | HEART rate variability biofeedback for long COVID symptoms (HEARTLOC): protocol for a feasibility study. | 2022 | BMJ open | Europe PMC; Preprint (medRxiv/bioRxiv); PubMed | NCT05228665 |
| PMID:36461167.0 | Effect of using a structured pacing protocol on post-exertional symptom exacerbation and health status in a longitudinal cohort with the post-COVID-19 syndrome. | 2023 | Journal of medical virology | OpenAlex; PubMed | nan |
| PMID:38224642.0 | Comorbid anxiety is associated with more changes in the Management of Postural Orthostatic Tachycardia Syndrome. | 2024 | General hospital psychiatry | Europe PMC; PubMed | nan |
| PMID:38540980.0 | The Head-Up Tilt Table Test as a Measure of Autonomic Functioning among Patients with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome. | 2024 | Journal of personalized medicine | Europe PMC; PubMed | nan |
| PMID:39071772.0 | Resonant breathing improves self-reported symptoms and wellbeing in people with Long COVID. | 2024 | Frontiers in rehabilitation sciences | Europe PMC; Preprint (medRxiv/bioRxiv); PubMed | nan |
| PMID:39109428.0 | Hyperadrenergic Postural Tachycardia Syndrome: Clinical Biomarkers and Response to Guanfacine. | 2024 | Hypertension (Dallas, Tex. : 1979) | Europe PMC; PubMed | nan |
| PMID:39690561.0 | [The role of drug Cytoflavin in the correction of dysautonomia in patients with post-COVID syndrome]. | 2024 | Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova | Europe PMC; PubMed | nan |
| PMID:40182801.0 | Symptomatic joint hypermobility is not a barrier to attendance, graduation, or satisfaction for adults participating in a multidisciplinary pain rehabilitation program. | 2025 | Frontiers in pain research (Lausanne, Switzerland) | Europe PMC; PubMed | nan |
| PMID:40308396.0 | Effectiveness of Dual Sympathetic Blocks for Sympathetically Mediated Symptoms in Post-acute Sequelae of SARS-CoV-2 (PASC): An Open-Label, Non-randomized Pilot Study. | 2025 | Cureus | Europe PMC; PubMed | nan |
| PMID:40835713.0 | Personalised & optimised therapy (POT) algorithm using five cognitive and behavioural skills for subthreshold depression. | 2025 | NPJ digital medicine | Europe PMC; PubMed | nan |
| PMID:40944028.0 | Autonomic Dysfunction in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS): Findings from the Multi-Site Clinical Assessment of ME/CFS (MCAM) Study in the USA. | 2025 | Journal of clinical medicine | Europe PMC; PubMed | nan |
| PMID:41038948.0 | Time-restricted eating improves quality of life, heart rate, and mitochondrial function in patients with postural orthostatic tachycardia syndrome. An open-label pilot study. | 2025 | Scientific reports | Europe PMC; PubMed | nan |
| PMID:41528744.0 | Prevalence of Central Sensitization in Postural Tachycardia Syndrome. | 2026 | JAMA network open | Europe PMC; PubMed | nan |
| PMID:42179241.0 | Comparative Analysis of Circulating Cytokines and Adrenergic Autoantibodies in Postural Orthostatic Tachycardia Syndrome, Postacute Sequelae of SARS-CoV-2, and Healthy Controls. | 2026 | Journal of the American Heart Association | Europe PMC; PubMed | nan |
| DOI | Effect on Quality of Life of Therapeutic Plasmapheresis in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Patients with Elevated Ꞵ-Adrenergic and M3-Muscarinic Receptor Antibodies – a Pilot Study | 2025 | nan | Preprint (medRxiv/bioRxiv) | nan |
| DOI | The Role of VSL#3® in the Treatment of Fatigue and Other Symptoms in Long Covid-19 Syndrome: a Randomized, Double-blind, Placebo-controlled Pilot Study (DELong#3) | 2023 | nan | Preprint (medRxiv/bioRxiv) | nan |
| — | Individual tailored physical training in patients with postural orthostatic tachycardia syndrome associated with post-acute COVID-19 syndrome - a feasibility study | 2023 | nan | Europe PMC | nan |
| PMID:36008726.0 | Immunotherapy with subcutaneous immunoglobulin or plasmapheresis in patients with postural orthostatic tachycardia syndrome (POTS). | 2023 | nan | Europe PMC | nan |
| PMID:34729276.0 | Management of Long-COVID Postural Orthostatic Tachycardia Syndrome With Enhanced External Counterpulsation. | 2021 | nan | Europe PMC | NCT05668039 |
| PMID:39839488.0 | The Diagnostic Journey of Dysautonomia Patients: Insights from a Patient-Reported Outcome Study | 2025 | Journal of Patient Experience | OpenAlex | nan |
| PMID:38003921.0 | Dysautonomia, but Not Cardiac Dysfunction, Is Common in a Cohort of Individuals with Long COVID | 2023 | Journal of Personalized Medicine | OpenAlex | nan |
| PMID:38516508.0 | Post-COVID-19 Syndrome and Related Dysautonomia: Reduced Quality of Life, Increased Anxiety and Manifestation of Depressive Symptoms: Evidence from Greece | 2023 | Acta medica Lituanica | OpenAlex | nan |
| NCT ID | Title | Status | Phase | Sponsor | Intervention |
|---|---|---|---|---|---|
| NCT03674541 | The Exercise Response to Pharmacologic Cholinergic Stimulation in Myalgic Encephalomyelitis / Chronic Fatigue Syndrome | COMPLETED | PHASE2 | Brigham and Women's Hospital | Pyridostigmine Bromide; Placebo |
| NCT05946551 | Feasibility Assessment of a Decentralized Platform Adaptive Double-Blind, Randomized Controlled Trial Investigating Repurposed Drugs in the Treatment of Post-Acute Sequelae of Coro | TERMINATED | PHASE3 | Emory University | Cetirizine; Famotidine; Cetirizine Placebo; Famotidine Placebo |
| NCT05619653 | Randomised Placebo Controlled Clinical Trial of Efficacy of MYOcardial Protection in Patients With Postacute inFLAMmatory Cardiac involvEment Due to COVID-19 | ACTIVE_NOT_RECRUITING | PHASE3 | Valentina Puentmann | Prednisolone; Losartan |
| NCT05823896 | An Interventional, Double-Blinded, 2-Arm Study to Investigate the Efficacy of Orally Administered Nirmatrelvir/Ritonavir Compared with Placebo/Ritonavir in Non-hospitalized Adult P | COMPLETED | PHASE2 | Karolinska Institutet | Nirmatrelvir/ritonavir; Placebo/ritonavir |
| NCT05638620 | Evaluating the Effectiveness of Dual Sympathetic Blocks for Patients Experiencing Sympathetically-Mediated Symptoms From Post-Acute Sequelae of SARS-CoV-2 (PASC) | COMPLETED | PHASE1 | Jonathann Kuo, MD | stellate ganglion block with 0.5% bupivacaine |
| NCT07280572 | RECLAIM: an Adaptive Platform Trial for the Evaluation of Treatments for Post-Acute Sequelae of SARS-CoV-2 Infection (PASC) | ENROLLING_BY_INVITATION | PHASE3 | Janneke van de Wijgert | Metformin; colchicine |
| NCT07238465 | Dysautonomia InVestigation in Individuals With Down SyndromE: DIVE Study | RECRUITING | PHASE3 | University of Colorado, Denver | Fear Response; Cold Stress; Pain Response; Caffeine; 12-Hour Fast; Maximal Dynamic Exercise |
| NCT05566379 | Effects of a Mindfulness Intervention on Physical and Psychological Well-Being and Quality of Life in Patients With Post Acute Sequelae of SARS-CoV-2 Infection (PASC) Dysautonomia | COMPLETED | nan | University of California, Los Angeles | Mindfulness - Mindful Awareness Practices ( MAPs) |
| NCT06172803 | RESToRE: Restoring Energy With Sub-symptom Threshold Optimized Rehabilitation Exercise for Long COVID | COMPLETED | nan | Columbia University | Restoring Energy with Sub-symptom Threshold Aerobic Rehabilitation Exercise; Light Stretching/Breathing Exercises |
| NCT06017232 | The ParkinSANTÉlé Study: A Multicomponent Telerehabilitation Program to Improve Cardiovascular Health in People With Parkinson's Disease With a Clinical Diagnosis of Dysautono | COMPLETED | nan | Université de Sherbrooke | Hybrid telerehabilitation program |
| NCT04919031 | Inspiratory Muscle Trainer Impact on Post Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) COVID-19 Hypertensive Patients With Long Term Persistent Symptoms | COMPLETED | nan | Cairo University | Inspiratory muscle trainer; diaphragmatic release |
| NCT05279430 | Effects of Inspiratory Muscle Training on Maximal Functional Capacity in Patients With Chronic COVID After Hospital Discharge | COMPLETED | nan | Fundación para la Investigación del Hospital Clínico de Valencia | Inspiratory muscle training |
| NCT05630040 | Vagus Nerve Simulation for Long-COVID-19 | COMPLETED | nan | Icahn School of Medicine at Mount Sinai | Non-invasive vagus nerve stimulation; Sham Intervention |
| NCT07359482 | sElective Serotonin reuPtake inhibitoRs In posT-covid: ESPRIT | NOT_YET_RECRUITING | PHASE3 | Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) | Fluvoxamine; Placebo |
| NCT07468604 | A Randomized Controlled Trial for Cervicothoracic Sympathetic Chain Block Against Sham Injection Evaluation for Post COVID Condition: the CeASE RCT | NOT_YET_RECRUITING | PHASE4 | University Health Network, Toronto | 5 mL of 0.25% bupivacaine with epinephrine (1:200,000); Sham Group |
| NCT07398508 | Phase I/II Study of NORTHERA (DROXIDOPA) for Dysautonomia in Pediatric Survivors of Menkes Disease: Double-blind Placebo-controlled Randomized Crossover Clinical Trial. | RECRUITING | PHASE1; PHASE2 | Stephen G. Kaler | Droxidopa Oral Product; Placebo Control |
| NCT05445830 | Physiological Characterization of Functional Limitations and Exercise Intolerance in Post-COVID Patients | ACTIVE_NOT_RECRUITING | nan | Karolinska Institutet | High-Intensity-Interval-Exercise; Moderate-Intensity-Continuous-Exercise; Strength training; Baseline assessment; 1 year follow-up |
| NCT03365414 | A Double Blind Randomized Controlled Crossover Study to Systematically Assess the Efficacy and Safety of Intravenous Albumin Infusions in Severe Postural Orthostatic Tachycardia Sy | WITHDRAWN | PHASE3 | University of Alberta | Albumin (Human) 5%, USP; Normal Saline 0.9% Infusion Solution Bag |
| NCT05554107 | The Effect of Physical Activity on Postural Orthostatic Tachycardia Syndrome | RECRUITING | nan | Lund University | Training program |
| NCT05421208 | Cardiovascular Autonomic and Immune Mechanism of Post COVID-19 Tachycardia Syndrome | RECRUITING | nan | Vanderbilt University Medical Center | Levels of inflammatory cytokine ( IL-6) in post-COVID-19 POTS and controls; Levels of inflammatory cytokine ( IL-6) in controls; Effect on inflammation after ch |
| NCT07478172 | Effects of Whole-body Electrical Muscle Stimulation Exercise on Adults withNeuromuscular Disease | RECRUITING | nan | University of Missouri-Columbia | Whole-body Electrical Muscle Stimulation Exercise |
| NCT07110714 | Effects of Kneipp Hydrotherapy in Post-COVID-19 Patients: A Randomized Controlled Trial | RECRUITING | nan | Eggensberger OHG | Cold water hydrotherapy |
| NCT05877534 | Effects of Individual Tailored Physical Exercise in Patients With Post COVID-19 Condition, Diagnosed With Postural Orthostatic Tachycardia Syndrome (POTS) - a Randomized Controlled | ENROLLING_BY_INVITATION | nan | Karolinska Institutet | Individual tailored exercise |
| NCT05566483 | Physiological Underpinnings of Post-Acute Sequelae of SARS CoV-2 ("Long COVID") and Impact of Cardiopulmonary Rehabilitation on Quality-of-Life and Functional Capacity | RECRUITING | nan | University of Colorado, Denver | Exercise |
| NCT05741112 | The Long COVID-19 Wearable Device Study | RECRUITING | nan | Scripps Translational Science Institute | Wearable device |
| NCT07013903 | Effects of Kneipp Hydrotherapy During Inpatient Post-Covid-19 Rehabilitation: A Randomized Controlled Trial | RECRUITING | nan | Schön Klinik Berchtesgadener Land | Standard rehabilitation plus cold water hydrotherapy; Standard rehabilitation only |
| NCT06027255 | Long COVID Immune Profiling | RECRUITING | nan | Vanderbilt University Medical Center | IL-6; cytokines (IL-17, and IFN-ɣ); Compass 31 |
| NCT07388550 | Phase I Open-Label Safety Trial of Pembrolizumab for Neurological Post-Acute Sequelae of SARS-CoV-2 (PD1-PASC I) | NOT_YET_RECRUITING | PHASE1 | National Institute of Neurological Disorders and Stroke (NINDS) | Keytruda |
| NCT07454395 | Investigating the Effect of Swimming on Autonomic and Symptomatic Responses in Individuals With Myalgic Encephalomyelitis/Chronic Fatigue Syndrome | SUSPENDED | nan | Simon Fraser University | Swimming; Cycling |
| NCT05629793 | Differential Diagnosis of Persistent COVID-19 by Artificial Intelligence | UNKNOWN | nan | Fundacin Biomedica Galicia Sur | Experimental tests |
| NCT05454683 | Effect of Melatonin Plus Zinc Supplementation on Fatigue, Pain, Sleep Disturbances, Anxiety and Depression, and Autonomic Dysfunction in ME/CFS: a Randomized, Double-blind, Placebo | UNKNOWN | nan | Laboratorios Viñas, S.A. | melatonin plus zinc; isomaltose and magnesium stearate |
| NCT04702217 | Physical Activity as a Complementary Treatment in Postural Orthostatic Tachycardia Syndrome - Evaluation of a Structured Physical Activity Program in Clinical Practice | WITHDRAWN | nan | Lund University | Training program |
| NCT05851846 | Amygdala Insula Retraining in the Management of Long COVID Symptoms | UNKNOWN | nan | Miami VA Healthcare System | Amygdala insula retraining |
| ID | Title | Year | Journal | Source | Linked NCTs |
|---|---|---|---|---|---|
| PMID:33792518.0 | Dyspnea in Chronic Low Ventricular Preload States. | 2021 | Annals of the American Thoracic Society | PubMed | nan |
| PMID:34821709.0 | Post-Acute Sequelae of COVID-19 and Cardiovascular Autonomic Dysfunction: What Do We Know? | 2021 | Journal of cardiovascular development and disease | Europe PMC; PubMed | NCT05566379 |
| PMID:35775163.0 | Long-term pulmonary sequelae in adolescents post-SARS-CoV-2 infection. | 2022 | Pediatric pulmonology | PubMed | nan |
| PMID:36169159.0 | Multi-disciplinary collaborative consensus guidance statement on the assessment and treatment of postacute sequelae of SARS-CoV-2 infection (PASC) in children and adolescents. | 2022 | PM & R : the journal of injury, function, and rehabilitation | OpenAlex; PubMed | nan |
| PMID:36461167.0 | Effect of using a structured pacing protocol on post-exertional symptom exacerbation and health status in a longitudinal cohort with the post-COVID-19 syndrome. | 2023 | Journal of medical virology | OpenAlex; PubMed | nan |
| PMID:36947108.0 | Pathogenic mechanisms of post-acute sequelae of SARS-CoV-2 infection (PASC). | 2023 | eLife | Europe PMC; PubMed | NCT05874089; NCT06940609 |
| PMID:37357041.0 | [The role of the cardiopulmonary exercise test and pulmonary rehabilitation in long COVID-19]. | 2023 | Revue des maladies respiratoires | Europe PMC; PubMed | nan |
| PMID:37598401.0 | Semi-supervised exercise training program more effective for individuals with postural orthostatic tachycardia syndrome in randomized controlled trial. | 2023 | Clinical autonomic research : official journal of the Clinical Autonomic Research Society | Europe PMC; OpenAlex; PubMed | nan |
| PMID:38279014.0 | Long COVID in pediatrics-epidemiology, diagnosis, and management. | 2024 | European journal of pediatrics | Europe PMC; PubMed | nan |
| PMID:38540980.0 | The Head-Up Tilt Table Test as a Measure of Autonomic Functioning among Patients with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome. | 2024 | Journal of personalized medicine | Europe PMC; PubMed | nan |
| PMID:38630952.0 | Case-Control Study of Individuals With Small Fiber Neuropathy After COVID-19. | 2024 | Neurology(R) neuroimmunology & neuroinflammation | Europe PMC; PubMed | nan |
| PMID:39071772.0 | Resonant breathing improves self-reported symptoms and wellbeing in people with Long COVID. | 2024 | Frontiers in rehabilitation sciences | Europe PMC; Preprint (medRxiv/bioRxiv); PubMed | nan |
| PMID:39117999.0 | Cardiopulmonary exercise testing in long covid shows the presence of dysautonomia or chronotropic incompetence independent of subjective exercise intolerance and fatigue. | 2024 | BMC cardiovascular disorders | Europe PMC; PubMed | nan |
| PMID:39127990.0 | A Practical Approach to Tailor the Term Long COVID for Diagnostics, Therapy and Epidemiological Research for Improved Long COVID Patient Care. | 2024 | Infectious diseases and therapy | Europe PMC; PubMed | nan |
| PMID:39181334.0 | Improving quality in adult long covid services: Findings from the LOCOMOTION quality improvement collaborative. | 2024 | Clinical medicine (London, England) | PubMed | nan |
| PMID:39847575.0 | Persistent symptoms and clinical findings in adults with post-acute sequelae of COVID-19/post-COVID-19 syndrome in the second year after acute infection: A population-based, nested case-control study. | 2025 | PLoS medicine | PubMed | nan |
| PMID:39850323.0 | Current update on the neurological manifestations of long COVID: more questions than answers. | 2024 | EXCLI journal | Europe PMC; PubMed | nan |
| PMID:40040864.0 | Preliminary evaluation of a mindfulness intervention program in women with long COVID dysautonomia symptoms. | 2025 | Brain, behavior, & immunity - health | Europe PMC; PubMed | nan |
| PMID:40261198.0 | Multidisciplinary collaborative guidance on the assessment and treatment of patients with Long COVID: A compendium statement. | 2025 | PM & R : the journal of injury, function, and rehabilitation | PubMed | nan |
| PMID:40264626.0 | Awareness and Perception of Myalgic Encephalomyelitis and Chronic Fatigue Syndrome Among Pain Specialists: A Questionnaire-Based Study. | 2025 | Cureus | Europe PMC; PubMed | nan |
| PMID:40546538.0 | A Survey-Based Study Examining Exercise in Postural Orthostatic Tachycardia Syndrome (POTS) Patients. | 2025 | Cureus | Europe PMC; PubMed | nan |
| PMID:40588382.0 | Assessing symptom improvement in patients with postural orthostatic tachycardia syndrome (POTS) following a 16-week structured exercise programme: a protocol for a randomised cross-over trial in a clinical outpatient set | 2025 | BMJ open | Europe PMC; PubMed | NCT05554107 |
| PMID:40627388.0 | Patient-reported treatment outcomes in ME/CFS and long COVID. | 2025 | Proceedings of the National Academy of Sciences of the United States of America | Europe PMC; OpenAlex; Preprint (medRxiv/bioRxiv); PubMed | nan |
| PMID:41132394.0 | Wearable technology in the management of complex chronic illness: preliminary survey results on self-reported outcomes. | 2025 | Frontiers in digital health | Europe PMC; PubMed | NCT07454395 |
| PMID:41300853.0 | The Clinical Relevance of Mast Cell Activation in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome. | 2025 | Diagnostics (Basel, Switzerland) | Europe PMC; PubMed | nan |
| PMID:41407606.0 | [Long covid pulmonary rehabilitation]. | 2026 | Revue des maladies respiratoires | Europe PMC; PubMed | nan |
| PMID:41598742.0 | An Overview of Severe Myalgic Encephalomyelitis. | 2026 | Journal of clinical medicine | Europe PMC; PubMed | nan |
| PMID:41715182.0 | Myalgic encephalomyelitis/chronic fatigue syndrome and fibromyalgia - overlap, differences, and emerging insights. | 2026 | Journal of translational medicine | PubMed | nan |
| PMID:41746717.0 | 2025 Clinical practice guidelines of the Mexican Society for HeartCare (SOMECCOR) and the Mexican Society of Cardiology (SMC) on Cardiovascular Rehabilitation and Prevention: therapeutic physical training and heart-healt | 2025 | Archivos de cardiologia de Mexico | Europe PMC; PubMed | nan |
| PMID:41849004.0 | Treatment of post-COVID symptoms with auricular vagus nerve stimulation. | 2026 | Wiener medizinische Wochenschrift (1946) | Europe PMC; PubMed | nan |
| PMID:41991875.0 | [Post-COVID: An inventory focusing on the key complaints PEM and POTS]. | 2026 | MMW Fortschritte der Medizin | Europe PMC; PubMed | nan |
| DOI | The Locus Coeruleus Norepinephrine Depletion Hypothesis of ME/CFS: A Mechanistic Model with Testable Predictions and Multimodal Study Plans (Protocol Framework) | 2025 | nan | Preprint (medRxiv/bioRxiv) | nan |
| DOI | Effect on Quality of Life of Therapeutic Plasmapheresis in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Patients with Elevated Ꞵ-Adrenergic and M3-Muscarinic Receptor Antibodies – a Pilot Study | 2025 | nan | Preprint (medRxiv/bioRxiv) | nan |
| DOI | Small Fiber Neuropathy after COVID-19: A Key to Long COVID | 2023 | nan | Preprint (medRxiv/bioRxiv) | nan |
| — | Breaking the silence: Recognizing post-vaccination syndrome | 2025 | nan | Europe PMC | nan |
| — | Individual tailored physical training in patients with postural orthostatic tachycardia syndrome associated with post-acute COVID-19 syndrome - a feasibility study | 2023 | nan | Europe PMC | nan |
| PMID:34729276.0 | Management of Long-COVID Postural Orthostatic Tachycardia Syndrome With Enhanced External Counterpulsation. | 2021 | nan | Europe PMC | NCT05668039 |
| PMID:34127505.0 | COVID-19-induced postural orthostatic tachycardia syndrome treated with ivabradine. | 2021 | nan | Europe PMC | nan |
| PMID:35201709.0 | Tinetti Gait and Balance Test | 2026 | nan | Europe PMC | nan |
Each trial is scored by trial status + phase + results bonus (+5 if results are available). Higher tiers represent more mature evidence. Tier 13 corresponds to completed Phase III/IV trials with results, assuming the configured status-priority scale.
Trials are grouped by their highest detected CT.gov phase and current recruitment/status. Mixed-phase studies such as Phase I/II are assigned to the higher phase.Where trials concentrate. Heavy density in Recruiting + Phase II tells you the field is mid-trial; density in Completed + Phase III is where evidence actually lands.
Who is being studied — sex eligibility, age inclusion windows, enrollment scale, and (where baseline data is posted) race/ethnicity breakdown of enrolled participants.
Sex eligibility, enrollment size, and age inclusion criteria across all 746 interventional trials. Enrollment values combine actual enrollment for completed/reporting trials and planned enrollment for ongoing trials, as reported by ClinicalTrials.gov.
Mean enrolled age across reporting trials: 44.8 yrs · Mean female proportion: 63.1% female · Total participants in race/ethnicity data: 17,384. Bars show aggregate counts across all trials that posted baseline demographics.
Cross-tab of age population type × sex eligibility. Answers queries like female-only trials in working-age adults directly.
CT.gov intervention type taxonomy, computed across 746 trials (each trial counted at most once per type). The largest categories: OTHER (251 trials, 34% — multi-modal rehabilitation, lifestyle, and complex-care interventions); DRUG (195, 26%); BEHAVIORAL (158, 21%). The combined weight of OTHER and BEHAVIORAL exceeds DRUG, meaning the KG schema must accommodate interventions that are not drug-with-dose entities. Trials with combination or multi-arm designs may appear in more than one type.
| NCT ID | Title | Status | Phase | Sponsor | Intervention |
|---|---|---|---|---|---|
| NCT05104749 | Homeopathic Treatment of Post-acute COVID-19 Syndrome- A Pilot Randomized Controlled Trial | COMPLETED | PHASE3 | Southwest College of Naturopathic Medicine | Homeopathic Medication; Placebo |
| NCT05999435 | A DOUBLE-BLIND, RANDOMIZED, PLACEBO-CONTROLLED, ADAPTIVE PHASE 2/3 STUDY OF THE EFFICACY OF LAU-7b IN THE TREATMENT OF ADULTS WITH LONG COVID AND MODERATE TO SEVERE SYMPTOMS | COMPLETED | PHASE2; PHASE3 | Laurent Pharmaceuticals Inc. | LAU-7b for 3 cycles; LAU-7b for 1 cycle, then placebo; Placebo for 3 cycles |
| NCT05970731 | Directed Topical Drug Delivery for Treatment for PASC Hyposmia | COMPLETED | PHASE2 | Duke University | Beclomethasone; Placebo; Microsponge |
| NCT05592418 | A Randomized, Double Blind, Placebo Controlled Study to Evaluate the Efficacy and Safety of Ampligen® in Patients With Post-COVID Conditions | COMPLETED | PHASE2 | AIM ImmunoTech Inc. | Rintatolimod; Placebo / Normal Saline |
| NCT04977388 | Phase I/II Study of NORTHERA (DROXIDOPA) for Dysautonomia in Adult Survivors of Menkes Disease and Adults With Occipital Horn Syndrome: Double-blind Placebo-controlled Randomized C | COMPLETED | PHASE1; PHASE2 | Stephen G. Kaler, MD | Droxidopa; Placebo |
| NCT05126563 | A Randomized, Double-blinded, Single-center, Phase 2 Efficacy, and Safety Study of Allogeneic HB-adMSCs for the Treatment of Patients With Chronic Post-COVID-19 Syndrome. | COMPLETED | PHASE2 | Hope Biosciences Research Foundation | HB-adMSCs (allogeneic); Placebo |
| NCT05965752 | RECOVER-NEURO: A Platform Protocol for Evaluation of Interventions for Cognitive Dysfunction in Post-Acute Sequelae of SARS-CoV-2 Infection (PASC) | COMPLETED | nan | Duke University | BrainHQ/Active Comparator Activity; BrainHQ; PASC CoRE; tDCS-active; tDCS-sham |
| NCT05877508 | An Exploratory, Randomized, Double-Blind Placebo-Controlled Study to Assess the Safety of an Anti-SARS-CoV-2 Monoclonal Antibody and Response to Treatment in Individuals With Long | ACTIVE_NOT_RECRUITING | PHASE2 | Michael Peluso, MD | AER002; Placebo |
| NCT06208696 | Pilot Study to Evaluate the Role of an Evidenced-based Chronic-disease Self-management Program to Support Challenges Experiencing Patients Living With Long-COVID and Chronic Diseas | COMPLETED | nan | University of Puerto Rico | "Tomando control de su salud" (Spanish Chronic Disease Self-Management) |
| NCT04880161 | A Randomized, Double-Blinded, Placebo-Controlled Phase I Study to Evaluate the Safety and Efficacy of Ampion in Patients With Prolonged Respiratory Symptoms Due to COVID-19 (Long C | COMPLETED | PHASE1 | Ampio Pharmaceuticals. Inc. | Ampion; Placebo |
| NCT06161688 | Placebo-Controlled, Randomized Trial of Ensitrelvir (S-217622) for Viral Persistence and Inflammation in People Experiencing Long COVID (PREVAIL-LC) | ACTIVE_NOT_RECRUITING | PHASE2 | Timothy Henrich | Ensitrelvir; Placebo |
| NCT06268288 | Pilot Study--The Effects of Non-invasive Vagal Neurostimulation (nVNS) in Adolescents With Postural Orthostatic Tachycardia Syndrome (POTS) | COMPLETED | nan | Mayo Clinic | GammaCore intervention; STEPS management protocol |
| NCT06214455 | The Effect of a No-added Sugar Diet, Time-restricted Eating and Periodic Water Fasting on Long COVID Symptoms | COMPLETED | nan | Pacific Northwest University of Health Sciences | Low sugar diet and 10-12 hour eating window; Low sugar diet, 8 hour eating window and fasting |
| NCT05473039 | OvoVid Study: Effect of a Multivitamin Supplement With Probiotic (Seidivid Ferty4®) on Oocyte Retrieval and Quality in Oocyte Donors. Double-blind Randomized Placebo-controlled Cli | COMPLETED | nan | SEID S.A. | Seidivid Ferty4; Placebo |
| NCT05513560 | REcovering From COVID-19 Lingering Symptoms Adaptive Integrative Medicine (RECLAIM) | COMPLETED | PHASE2; PHASE3 | University Health Network, Toronto | Ibudilast; Pentoxifylline; Placebo |
| NCT05939622 | Prospective Randomized Double Blind Placebo Controlled Study of Efficacy of the Therapy With BRAINMAX® Using Functional Magnetic Resonance Imaging (fMRI) for the Treatment of Patie | COMPLETED | PHASE4 | Promomed, LLC | Structural and functional MRI; Ethyl methyl hydroxypyridine succinate + Meldonium; Placebo |
| NCT04795557 | Effect of ADAPT232 Supplementation on Recovery of Patients in Rehabilitation Period in Long COVID-19: a Randomized, Double-blind, Placebo-controlled Trial | COMPLETED | PHASE2; PHASE3 | Swedish Herbal Institute AB | ADAPT-232 oral solution; Placebo oral solution |
| NCT06208761 | Effects of Triphala Supplementation and High-intensity Interval Exercise on Immune System Function and Oxidative Stress in People With Long COVID | COMPLETED | PHASE2 | Burapha University | Triphala capsule supplementation and high-intensity interval training |
| NCT05228899 | A Phase I/II Multicenter, Randomized, Double Blinded, Placebo Trial to Evaluate the Safety and Potential Efficacy of Zofin Infused Intravenous (IV) in Patients Experiencing Prolong | COMPLETED | PHASE1; PHASE2 | ZEO ScientifiX, Inc. | Zofin; Placebo |
| NCT04904536 | An International, Investigator Initiated and Conducted, Pragmatic Clinical Trial to Determine Whether 40mg Atorvastatin Daily Can Improve Neurocognitive Function in Adults With Lon | ACTIVE_NOT_RECRUITING | PHASE3 | The George Institute | Atorvastatin; Standard Care |
| NCT05430152 | A Double Blind Randomized Trial of Low-dose Naltrexone for Post-COVID Fatigue Syndrome | COMPLETED | PHASE2 | Luis Nacul | Low-Dose Naltrexone; Placebo |
| NCT05212688 | A Randomised Phase II Study to Investigate the Effectiveness of ACUpuncture for the Relief of Long COVID Related Fatigue. | COMPLETED | PHASE2 | Royal Marsden NHS Foundation Trust | Acupuncture; Active Control |
| NCT05445674 | Plasma Exchange Therapy for Post- COVID-19 Condition: A Pilot, Randomized Double-Blind Study | COMPLETED | PHASE2 | Fundación FLS de Lucha Contra el Sida, las Enfermedades Infecciosas y la Promoción de la Salud y la Ciencia | Plasma Exchange Procedure; Sham Plasma Exchange Procedure |
| NCT05323331 | Effects of Circuit Training Program on Cardiopulmonary Parameters and Functional Capacity in Post COVID 19 Patients | COMPLETED | nan | Riphah International University | Circuit Training Exercise Program; Aerobic Training Exercise Program |
| NCT06404073 | RECOVER-ENERGIZE: A Platform Protocol for Evaluation of Interventions for Exercise Intolerance in Post-Acute Sequelae of SARS-CoV-2 Infection (PASC) | COMPLETED | nan | Duke University | Structured Pacing; Usual Care |
| NCT05299333 | Comparison of the Effectiveness of Pulmonary Telerehabilitation and Physical Activity Recommendations in Patients With Pulmonary Fibrosis Due to COVID-19 | COMPLETED | nan | Istanbul University - Cerrahpasa | Exercise |
| NCT04771598 | EVALUATING THE EFFICIENCY OF BREATHING EXERCISES PERFORMED BY POST-COVID TELEMEDICINE: Randomized Controlled Study | COMPLETED | nan | Tokat Gaziosmanpasa University | Breathing exercise with the phone application; Breathing exercise |
| NCT05196529 | Inspiratory Muscle Training in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) and COVID-19 Survivors | COMPLETED | nan | York University | Inspiratory muscle training |
| NCT05119634 | The Effect of Whole Body Vibration Training in Individuals With Post COVID - 19 | COMPLETED | nan | Istanbul University - Cerrahpasa | whole body vibration training; home based exercises |
| NCT05107440 | BREATHE: A Mixed-methods Evaluation of a Virtual Self-management Program for People Living With Long COVID-19 in Alberta | COMPLETED | nan | University of Calgary | BREATHE |
| NCT05218174 | Exercise Training and Functional, Cognitive, and Emotional Well-being in Adults with Post-Acute Sequelae of SARS-CoV-2 (COVID-19) Infection (PASC): a Randomized Controlled Trial | COMPLETED | nan | Baylor Research Institute | Exercise Prescription |
| NCT05112887 | Osteopathic Manipulative Therapy Effects on Prolonged Post-COVID Olfactory Dysfunction | COMPLETED | nan | Ohio University | Osteopathic Manipulative Therapy |
| NCT05911113 | Impact Of Sensory Re-Education Paradigm On Sensation And Quality Of Life In Patients Post-Covid 19 Polyneuropathy | COMPLETED | nan | Cairo University | sensory re-education training; traditional treatment |
| NCT05216549 | Water and Land-based Exercise for Children With Post COVID-19 Condition | COMPLETED | nan | Józef Piłsudski University of Physical Education | Water-based exercise; Land-based exercise |
| NCT05840237 | REGAIN: A Randomized, Double Blind, Placebo Controlled Trial to Determine the Effects of Oxaloacetate on Improving Fatigue in Long COVID | COMPLETED | nan | Terra Biological LLC | Anhydrous Enol-Oxaloacetate, a "Medical Food"; White Rice Flour |
| NCT06330376 | Diaphragmatic Breathing Exercises for Post-COVID-19 Diaphragmatic Dysfunction (DD) | COMPLETED | nan | University of Minnesota | Usual care of traditional treatment; Specific DB program/Diaphragmatic manipulation program |
| NCT05024474 | Effects of Inspiratory Muscle Training After Covid-19 | COMPLETED | nan | Karolinska Institutet | Inspiratory muscle training (IMT); Physical exercise |
| NCT06952127 | Pilot Study Evaluating the Feasibility and Appropriateness of a Telerehabilitation Exercise Program in People With Post-COVID-19 Sequelae: a Single-center Randomized Trial. | COMPLETED | nan | Centre intégré universitaire de santé et de services sociaux de la Mauricie-et-du-Centre-du-Québec | Rehabilitation program |
| NCT05601180 | Interventional, Prospective, National, Multicentre, Randomised, Open-label, Controlled Clinical Study Comparing Two Parallel Groups, One Control Arm (Standard Treatment) Versus Int | COMPLETED | nan | Beker Laboratories | Respicure®; Standard of care |
| NCT05866224 | Effects of a Telerehabilitation Program and Detraining on Cardiorespiratory Fitness in Patients With Post-COVID-19 Sequelae | COMPLETED | nan | Campus docent Sant Joan de Déu-Universitat de Barcelona | Telerehabilitation program |
| NCT06492551 | Prospective Clinical Trial of Trak Tool Usage in Post-COVID-19 Patients. | COMPLETED | nan | Trak Health Solutions S.L. | Trak exercise prescription protocol; Conventional rehabilitation plan in the gym |
| NCT05973136 | A Pilot Study to Evaluate the Implantation and the Impact of a Hybrid Telerehabilitation Program Based on Cardiopulmonary Rehabilitation Principles for People With Post-COVID Affec | COMPLETED | nan | Université de Sherbrooke | Telerehabilitation program based on cardiorespiratory principles |
| NCT06535165 | Effect of 14-day Red Beetroot Juice Intake on Physical Function, Gut Microbiota Composition, and Systemic Inflammation in Adults With Long COVID-19 | COMPLETED | nan | Catholic University of the Sacred Heart | Red Beetroot Juice; Placebo |
| NCT05855369 | A Randomized Controlled Trial of Smell Training and Trigeminal Nerve Stimulation in the Treatment of COVID-related Persistent Smell Loss | RECRUITING | PHASE2; PHASE3 | Medical University of South Carolina | Trigeminal Nerve Stimulation (TNS); Active Smell Training (ST); Placebo Smell Training (PBO) |
| NCT05758480 | Characterization of the Immunometabolic Signature in Long COVID-19. | COMPLETED | nan | University Hospital, Angers | Blood sample (at inclusion and 6 months later); Patient questionnaires (at inclusion and 6 months later) |
| NCT05244044 | Changes in Functional Exercise Capacity After PUlmonary REhabilitation in Primary Care: a Randomized, Controlled, Multicenter, Pragmatic Trial in 134 Patients With Long COVID (PuRe | COMPLETED | nan | University Hospital, Antwerp | Pulmonary rehabilitation in primary care |
| NCT05630378 | Evaluation of a Multimodal Integrative Medicine and Naturopathy Program in an Outpatient Setting With Focus on Mind-Body Medicine and Mild Water-filtered Infrared-A Whole-body Hype | COMPLETED | nan | Universität Duisburg-Essen | outpatient clinic with multimodal integrative medicine and naturopathy for post-COVID-19 patients; waiting group |
| NCT07029191 | SYMPA-VEIN : Pilot Study Evaluating the ACCUVEIN Superficial Vein Visualization Device for the Detection of Alterations in the Autonomic Nervous System | COMPLETED | nan | University Hospital, Angers | Progressive standing test |
| NCT04845737 | Evaluation of the Relationship Between Electrophysiological Findings With Vitamin D Levels and Inflammatory Parameters in Fibromyalgia Patients | COMPLETED | nan | Abant Izzet Baysal University | sympathetic skin response measurement |
| NCT05273372 | A Randomized Double Blind Placebo Controlled Trial to Determine the Effects of Oxaloacetate on Improving Fatigue in ME/CFS | COMPLETED | nan | Terra Biological LLC | Placebo; Medical Food - Anhydrous Enol-Oxaloacetate |
| NCT ID | Title | Status | Phase | Sponsor | Intervention |
|---|---|---|---|---|---|
| NCT04871815 | Preliminary Examination of the Effects of Sodium Pyruvate Nasal Spray (N115) on Symptoms Associated With COVID19 Long Haulers. | COMPLETED | PHASE2; PHASE3 | Cellular Sciences, inc. | sodium pyruvate nasal spray |
| NCT05104749 | Homeopathic Treatment of Post-acute COVID-19 Syndrome- A Pilot Randomized Controlled Trial | COMPLETED | PHASE3 | Southwest College of Naturopathic Medicine | Homeopathic Medication; Placebo |
| NCT04510194 | COVID-OUT: Early Outpatient Treatment for SARS-CoV-2 Infection (COVID-19) | COMPLETED | PHASE3 | University of Minnesota | Metformin; Placebo; Fluvoxamine; Ivermectin |
| NCT05999435 | A DOUBLE-BLIND, RANDOMIZED, PLACEBO-CONTROLLED, ADAPTIVE PHASE 2/3 STUDY OF THE EFFICACY OF LAU-7b IN THE TREATMENT OF ADULTS WITH LONG COVID AND MODERATE TO SEVERE SYMPTOMS | COMPLETED | PHASE2; PHASE3 | Laurent Pharmaceuticals Inc. | LAU-7b for 3 cycles; LAU-7b for 1 cycle, then placebo; Placebo for 3 cycles |
| NCT05074888 | A Multicenter, Double-blind, Placebo-controlled, Parallel-group, Randomized Clinical Trial of Efficacy and Safety of Prospekta in the Treatment of Patients With Post-COVID-19 Asthe | COMPLETED | PHASE3 | Materia Medica Holding | Prospekta; Placebo |
| NCT05047952 | Randomized, Double-Blinded, Placebo-Controlled Study Evaluating Vortioxetine for Cognitive Deficits in Persons With Post-COVID-19 Condition | COMPLETED | PHASE2 | Brain and Cognition Discovery Foundation | Vortioxetine; Placebo |
| NCT05970731 | Directed Topical Drug Delivery for Treatment for PASC Hyposmia | COMPLETED | PHASE2 | Duke University | Beclomethasone; Placebo; Microsponge |
| NCT05633407 | A Phase 2 Randomized, Double-blinded, Placebo-controlled Study to Evaluate the Efficacy and Safety of Efgartigimod IV in Adult Patients With Post-COVID-19 Postural Orthostatic Tach | COMPLETED | PHASE2 | argenx | Efgartigimod; Placebo |
| NCT04920916 | Safety and Efficacy of the Treatment of Hospitalized Patients With COVID 19 Infection With an Inhibitor of IL-4 and IL-13 Signaling: A Phase IIa Trial | COMPLETED | PHASE2 | University of Virginia | Dupilumab; Placebo |
| NCT05618587 | Effect of Low-dose Lithium Therapy on Long COVID Symptoms: a Randomized Controlled Trial. | COMPLETED | PHASE2 | State University of New York at Buffalo | Lithium; Placebo |
| NCT05592418 | A Randomized, Double Blind, Placebo Controlled Study to Evaluate the Efficacy and Safety of Ampligen® in Patients With Post-COVID Conditions | COMPLETED | PHASE2 | AIM ImmunoTech Inc. | Rintatolimod; Placebo / Normal Saline |
| NCT05121740 | Extension Study in a Cohort of Adult Patients With SARS-CoV-2 Infection Requiring Hospital Admission and Received Treatment With Plitidepsin in the APLICOV-PC Study | COMPLETED | PHASE1; PHASE2 | PharmaMar | Plitidepsin 1.5 mg / day; Plitidepsin 2.0 mg / day; Plitidepsin 2.5 mg / day |
| NCT05576662 | Selective Trial Of Paxlovid for PASC (STOP-PASC): Randomized Double-Blind Placebo-Controlled Pilot Trial of Paxlovid for the Treatment of PASC | COMPLETED | PHASE2 | Stanford University | Nirmatrelvir; Placebo; Ritonavir |
| NCT04141696 | A Proof-of-Concept Trial on the Effect of Ketamine on Fatigue | COMPLETED | PHASE1; PHASE2 | National Institute of Nursing Research (NINR) | Ketamine; Midazolam |
| NCT06133075 | Using Mirabegron to Increase Blood Pressure in Patients With Postural Orthostatic Tachycardia Syndrome | COMPLETED | PHASE2 | Cedars-Sinai Medical Center | Mirabegron 50 MG; Mirabegron 25 MG |
| NCT05965726 | RECOVER-VITAL: A Platform Protocol for Evaluation of Interventions for Viral Persistence, Viral Reactivation, and Immune Dysregulation in Post-Acute Sequelae of SARS-CoV-2 Infectio | COMPLETED | PHASE2 | Kanecia Obie Zimmerman | Paxlovid; Ritonavir; Nirmatrelvir-matching placebo |
| NCT04977388 | Phase I/II Study of NORTHERA (DROXIDOPA) for Dysautonomia in Adult Survivors of Menkes Disease and Adults With Occipital Horn Syndrome: Double-blind Placebo-controlled Randomized C | COMPLETED | PHASE1; PHASE2 | Stephen G. Kaler, MD | Droxidopa; Placebo |
| NCT06253806 | Stellate Ganglion Block for the Treatment of COVID-19-Induced Parosmia: Double-Blinded, Placebo-Controlled Randomized Clinical Trial | COMPLETED | PHASE2 | Washington University School of Medicine | Stellate Ganglion Block; Placebo Sham Injection |
| NCT03674541 | The Exercise Response to Pharmacologic Cholinergic Stimulation in Myalgic Encephalomyelitis / Chronic Fatigue Syndrome | COMPLETED | PHASE2 | Brigham and Women's Hospital | Pyridostigmine Bromide; Placebo |
| NCT05595369 | RECOVER-VITAL: A Platform Protocol for Evaluation of Interventions for Viral Persistence, Viral Reactivation, and Immune Dysregulation in Post-Acute Sequelae of SARS-CoV-2 Infectio | COMPLETED | PHASE2 | Kanecia Obie Zimmerman | Experimental: Paxlovid 25 day dosing; Experimental: Paxlovid 15 day dosing; Placebo Comparator: Control |
| NCT05445921 | Stellate Ganglion Block for the Treatment of COVID-19-Induced Olfactory Dysfunction: A Prospective Pilot Study | COMPLETED | PHASE1; PHASE2 | Washington University School of Medicine | Stellate Ganglion Block |
| NCT05472090 | A Phase 2, 14-week Double-Blind, Randomized, Multicenter, Placebo-Controlled Study to Evaluate the Efficacy and Safety of TNX-102 SL Taken Daily at Bedtime in Patients With Multisi | COMPLETED | PHASE2 | Tonix Pharmaceuticals, Inc. | TNX-102 SL; Placebo SL Tablet |
| NCT04828135 | Characterizing the Long-Term Cardiopulmonary Effects of COVID-19 With Hyperpolarized Xenon and Cardiac MRI | COMPLETED | PHASE2 | Bastiaan Driehuys | Hyperpolarized 129Xenon gas |
| NCT05877508 | An Exploratory, Randomized, Double-Blind Placebo-Controlled Study to Assess the Safety of an Anti-SARS-CoV-2 Monoclonal Antibody and Response to Treatment in Individuals With Long | ACTIVE_NOT_RECRUITING | PHASE2 | Michael Peluso, MD | AER002; Placebo |
| NCT06161688 | Placebo-Controlled, Randomized Trial of Ensitrelvir (S-217622) for Viral Persistence and Inflammation in People Experiencing Long COVID (PREVAIL-LC) | ACTIVE_NOT_RECRUITING | PHASE2 | Timothy Henrich | Ensitrelvir; Placebo |
| NCT05946551 | Feasibility Assessment of a Decentralized Platform Adaptive Double-Blind, Randomized Controlled Trial Investigating Repurposed Drugs in the Treatment of Post-Acute Sequelae of Coro | TERMINATED | PHASE3 | Emory University | Cetirizine; Famotidine; Cetirizine Placebo; Famotidine Placebo |
| NCT05597722 | Randomized Study to Evaluate Strategies to Address Cognitive Fog in Long-COVID-19 Patients | TERMINATED | PHASE4 | Eva Szigethy | Digital cognitive behavioral intervention-RxWell; Amphetamine-Dextroamphetamine |
| NCT04313972 | IC PaIN Trial: Interstitial Cystitis Pain Improvement With Naltrexone, the Effect of Low Dose Naltrexone on Symptoms and Pain of Patients With Interstitial Cystitis/Painful Bladder | TERMINATED | PHASE4 | Endeavor Health | low-dose naltrexone; Placebo oral tablet |
| NCT05918978 | Open-Label Extension Study to Evaluate the Long-term Safety and Efficacy of Efgartigimod in Adult Patients With Post-COVID-19 Postural Orthostatic Tachycardia Syndrome (PC-POTS) Wh | TERMINATED | PHASE2 | argenx | Efgartigimod |
| NCT05204550 | A Randomised, Placebo-controlled Trial to Investigate the Efficacy of Intranasal Heparin Treatment to Reduce Transmission of SARS-CoV-2 Infection and COVID 19 Disease Among Househo | COMPLETED | PHASE2; PHASE3 | Murdoch Childrens Research Institute | unfractionated heparin; 0.9%sodium chloride |
| NCT05513560 | REcovering From COVID-19 Lingering Symptoms Adaptive Integrative Medicine (RECLAIM) | COMPLETED | PHASE2; PHASE3 | University Health Network, Toronto | Ibudilast; Pentoxifylline; Placebo |
| NCT05096884 | Post-Acute Sequelae of Coronavirus-19 (COVID-19) With DysPnEA on ExertIon And Associated TaChycardia TrEatment Study | TERMINATED | EARLY_PHASE1 | Hackensack Meridian Health | Metoprolol Succinate |
| NCT04988282 | Systemic Corticosteroids in Treatment of Post-COVID-19 Interstitial Lung Disease | COMPLETED | PHASE4 | Turkish Thoracic Society | Methylprednisolone Tablet |
| NCT05638633 | Prednisolone and Vitamin B1, B6, and B12 in Patients With Post-COVID-19-Syndrome (PC19S) - a Randomized Controlled Trial in Primary Care | COMPLETED | PHASE3 | Wuerzburg University Hospital | Prednisolone 20 mg/ 5 mg; Vitamin B compound (100mg B1, 50 mg B6, 500 µg B12); Placebo for Vitamin B compound; Placebo for Prednisolon |
| NCT04591210 | Evaluation of the Potential Benefit of Renin-angiotensin System Inhibitors (RASi, ACEi/ARB) in High-risk Patients With COVID-19. The COVID-RASi Trial | COMPLETED | PHASE3 | Ottawa Heart Institute Research Corporation | Angiotensin converting enzyme inhibitor; Angiotensin II Receptor Blockers |
| NCT05795816 | The Effectiveness of Testofen on Energy, Fatigue, Mental Acuity, and Other Quality of Life Symptoms Post COVID-19 Infection | COMPLETED | PHASE3 | RDC Clinical Pty Ltd | Testofen; Microcrystalline cellulose |
| NCT05939622 | Prospective Randomized Double Blind Placebo Controlled Study of Efficacy of the Therapy With BRAINMAX® Using Functional Magnetic Resonance Imaging (fMRI) for the Treatment of Patie | COMPLETED | PHASE4 | Promomed, LLC | Structural and functional MRI; Ethyl methyl hydroxypyridine succinate + Meldonium; Placebo |
| NCT05524532 | Effect of Immulina Supplements on Inflammatory Biomarkers Correlated With Clinical Symptoms in Patients With Long COVID (PASC) | COMPLETED | PHASE3 | University of Mississippi Medical Center | Immulina TM; Placebo |
| NCT04830943 | The Effectiveness of Cerebrolycin, a Multi-modal Neurotrophic Factor, for Treatment of Post-covid-19 Persistent Olfactory, Gustatory and Trigeminal Chemosensory Dysfunctions: A Pil | COMPLETED | PHASE3 | Assiut University | Cerebrolysin |
| NCT04622293 | A Double-Blind, Randomized, Placebo-Controlled, Single-Center, Flexible Titration Study Evaluating the Efficacy of Solriamfetol in Treating Fatigue and Cognitive Symptoms in Adults | COMPLETED | PHASE4 | Rochester Center for Behavioral Medicine | Solriamfetol Oral Tablet [Sunosi]; Placebo |
| NCT05911906 | An Open-label, Clinical Feasibility Study of the Efficacy of Remdesivir for Long-COVID. | COMPLETED | PHASE4 | University of Derby | Remdesivir |
| NCT06245642 | A Multi-center, Randomized, Double-blind, Positive Parallel Control Study of Compound Ciwujia Granules in the Treatment of Chronic Fatigue Syndrome (Spleen-kidney Deficiency Syndro | COMPLETED | PHASE4 | Heilongjiang Quanle Pharmaceutical Co., Ltd. | Compound Ciwujia Granules, Guipi Granules |
| NCT05890534 | Pycnogenol® in People With Post-COVID-19 Condition: a Quadruple-blind, Randomized, Placebo-controlled Trial | COMPLETED | PHASE3 | University of Zurich | Pycnogenol®; Placebo |
| NCT06383819 | Multicenter, Randomized, Double-blind, Placebo-controlled Parallel-group Study to Evaluate the Efficacy and Safety of Longidaza® for the Treatment of Patients With Residual Changes | COMPLETED | PHASE3 | NPO Petrovax | Longidaza®; Placebo |
| NCT05121766 | Feasibility Pilot Clinical Trial of Omega-3 (EPA+DHA) Supplement vs. Placebo for Post-Acute Sequelae of Coronavirus-19 (COVID-19) Recovery Among Health Care Workers | TERMINATED | PHASE1 | Hackensack Meridian Health | Omega-3 (EPA+DHA); Placebo |
| NCT05642923 | Post-COVID-19 Chronic Fatigue Syndrome | COMPLETED | PHASE4 | ClinAmygate | Synthetic Vitamin B1 |
| NCT05874037 | Fluvoxamine as a Treatment for Long COVID-19: A Randomized Placebo Controlled Trial | COMPLETED | PHASE2; PHASE3 | Washington University School of Medicine | Fluvoxamine |
| NCT06128967 | An Adaptive, Randomized, doublE-blind, Placebo-controlled, Prospective, Pharmacological interVention Study In Participants With Long COVID-19 Syndrome: REVIVE-TOGETHER Trial | COMPLETED | PHASE3 | Cardresearch | Fluvoxamine Maleate 100 MG; Placebo; Metformin Extended Release Oral Tablet |
| NCT06437223 | A Phase 2 Study to Compare the Efficacy and Safety of Orally Administered Xiflam™ Therapy With Orally Administered Placebo in Patients With Ocular and Systemic Manifestations of Po | COMPLETED | PHASE2 | Inflammx Therapeutics Inc | Tonabersat; Placebo |
| NCT06404112 | RECOVER-SLEEP: A Platform Protocol for Evaluation of Interventions for Sleep Disturbances in Post-Acute Sequelae of SARS-CoV-2 Infection (PASC) | COMPLETED | PHASE2 | Duke University | Melatonin; Melantonin Placebo; Tailored lighting (TL) Active; Tailored lighting (TL) Placebo |
| NCT ID | Title | Status | Phase | Sponsor | Intervention |
|---|---|---|---|---|---|
| NCT06136871 | Cognitive Strategy Training in Post-COVID-19 Syndrome: A Feasibility Trial | COMPLETED | nan | University of Missouri-Columbia | CO-OP Procedures; Inactive Control Group |
| NCT05453201 | Developing an Integrative, Recovery-Based, Post-Acute COVID-19 Syndrome (PACS) Psychotherapeutic Intervention | COMPLETED | nan | VA Office of Research and Development | Long COVID Coping and Recovery (LCCR) Intervention |
| NCT05205460 | Effectiveness of a 12-week Telerehabilitation Training in People With Long COVID: A Randomized Controlled Trial | COMPLETED | nan | Tri-Service General Hospital | Home-based telerehabilitation; Education and self-exercise |
| NCT05597722 | Randomized Study to Evaluate Strategies to Address Cognitive Fog in Long-COVID-19 Patients | TERMINATED | PHASE4 | Eva Szigethy | Digital cognitive behavioral intervention-RxWell; Amphetamine-Dextroamphetamine |
| NCT04961190 | A Comparison of Prolonged Exposure Therapy, Pharmacotherapy, and Their Combination for PTSD: What Works Best, and for Whom | ACTIVE_NOT_RECRUITING | PHASE4 | University of Pennsylvania | Prolonged Exposure Therapy; Pharmacotherapy with paroxetine or venlafaxine XR |
| NCT06305806 | RECOVER-AUTONOMIC (Ivabradine): Randomized Trial of the Effect of Ivabradine Versus Placebo on Long COVID Symptoms | COMPLETED | PHASE2 | Kanecia Obie Zimmerman | Ivabradine; Ivabradine Placebo; Coordinated Care; Usual Care |
| NCT06840873 | Effectiveness of a 8-week Tele-Rehabilitative Exercise Training Program on Fatigue, Symptom Severity, and Quality of Life in Nurses With Long COVID: A Randomized Controlled Trial | COMPLETED | nan | Shang-Lin Chiang | wearable device; Healthy consulation |
| NCT06404073 | RECOVER-ENERGIZE: A Platform Protocol for Evaluation of Interventions for Exercise Intolerance in Post-Acute Sequelae of SARS-CoV-2 Infection (PASC) | COMPLETED | nan | Duke University | Structured Pacing; Usual Care |
| NCT05194059 | ActiPacMAN: 'Activity Pacing' in PLWH With Fatigue Symptoms. Monitoring Through the Combined Use of Actigraphy and Mobile App Notifications | COMPLETED | nan | Scientific Institute San Raffaele | Home-based physical activity |
| NCT06441955 | Covid-19 Long Haul Syndrome: Undiagnosed Disorder Post Covid-19 Alternative Treatment Study. | RECRUITING | PHASE4 | Well- Konnect Healthcare Services and Research Firm | Ritonavir-Boosted Nirmatrelvir (Paxlovid); Physiological Evaluation; Moderna COVID-19 Vaccine; Biopsychological; Behavioral (e.g., Psychotherapy, Lifestyle Coun |
| NCT05703074 | The Efficacy and Safety of a Mental Intervention Program vs. Usual Care and Nicotinamide Riboside (NR) vs. Placebo for Improving Health-related Quality of Life in Long Covid: A 2 x | ACTIVE_NOT_RECRUITING | PHASE2 | University Hospital, Akershus | Nicotinamide Riboside (NR); Mind-body reprocessing therapy (MBRT); Care as usual; Placebo |
| NCT06776276 | The Impact of Adding Tai-chi Training to Pharmacotherapy in Post Covid Insomnia: a Prospective Study. | COMPLETED | nan | Alexandria University | Tai Chi exercises |
| NCT05196451 | Short-time Behavioural Intervention in Post-Covid Syndrome (SIPCOV): A Pragmatic Randomised Controlled Trial | COMPLETED | nan | University Hospital, Akershus | Rehabilitation based on CBT principles |
| NCT06091293 | Narrative Intervention for Long COVID-19 (NICO) Research Study | COMPLETED | nan | University of Colorado, Denver | Narrative Intervention for Long COVID-19 (NICO) |
| NCT06658340 | Positivity in Post-COVID: Promoting Well-being in Patients with Post-COVID-19 Syndrome - a Feasibility and Acceptability Study | COMPLETED | nan | University of Twente | Positivity in Post-COVID |
| NCT06004310 | Effect of Pulmonary Rehabilitation Among Post-COVID-19 Patients in a Tertiary Care Hospital in Bangladesh: A Quasi-Experimental Study | COMPLETED | nan | Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh | Pulmonary Rehabilitation |
| NCT06393790 | Health Effects of a Strength Training Protocol in Women With Fibromyalgia and Healthy Individuals. | COMPLETED | nan | Catholic University of Murcia | FMG (Fibromyalgia group); HG (Healthy group) |
| NCT05630378 | Evaluation of a Multimodal Integrative Medicine and Naturopathy Program in an Outpatient Setting With Focus on Mind-Body Medicine and Mild Water-filtered Infrared-A Whole-body Hype | COMPLETED | nan | Universität Duisburg-Essen | outpatient clinic with multimodal integrative medicine and naturopathy for post-COVID-19 patients; waiting group |
| NCT06726772 | Post-COVID-19 Symptom Burden: Effects of an Outpatient Group Psychotherapy in Long COVID Patients | COMPLETED | nan | Cantonal Hospital of St. Gallen | Group Psychotherapy |
| NCT06814379 | Rehabilitation of Fatigue in Patients With Post-COVID-19 Syndrome | COMPLETED | nan | Universidad de Granada | Rehabilitation; Virtual reality based rehabilitation |
| NCT07301580 | Physical Prehabilitation of Breast Cancer-Related Lymphedema | COMPLETED | nan | University of Health Sciences Balikesir Hospital Eduation and Research | Prehabilitation Exercise Group |
| NCT07184398 | Use of a Cysteine-rich Whey Protein Isolate (Immunocal®) in Post COVID-19 Cognitive Impairment | COMPLETED | nan | Universidad Libre seccional Cali | Intervention with Consolidated Cysteine (Immunocal) 20 g per day; Cognitive rehabilitation workshops |
| NCT05699538 | Fatigue and Fatigability in Veterans Following SARS-CoV-2 Infection | COMPLETED | nan | VA Office of Research and Development | Minimal-Dose Home-Based Resistance Exercise |
| NCT05676047 | Symptom-Targeted Rehabilitation for Cognitive Complaints in Long COVID (STAR-C3) | COMPLETED | nan | McMaster University | Cognitive Rehabilitation; Education |
| NCT05798221 | Complementary Self-help Strategies for Patients With Post-COVID-19 Syndrome: A Randomized Controlled Trial | COMPLETED | nan | Universität Duisburg-Essen | Complementary self-help strategies in addition to treatment as usual; Treatment as usual |
| NCT07553897 | Effectiveness of a Tele-Exercise Training Program on Long COVID Symptoms and Quality of Life in Patients With Long COVID | COMPLETED | nan | Tri-Service General Hospital | Telehealth exercise training program; Education and self-exercise |
| NCT05139979 | Yogic Breathing and Guided Meditation for Long Covid Symptoms | COMPLETED | nan | Beth Israel Deaconess Medical Center | Breathing and Wellness Webinar; Routine Daily Activity |
| NCT04603157 | Remote Self-training Program for Patients With Postural Orthostatic Tachycardia Syndrome (POTS) | COMPLETED | nan | Mayo Clinic | Hybrid Exercise Training |
| NCT05675995 | Qigong for Post Acute Sequelae of COVID-19 Infection | COMPLETED | nan | University of California, Davis | Qigong |
| NCT05469477 | Behavioral Interventions to Increase Seat Belt Wearing and Decrease Handheld Phone Use While Driving | COMPLETED | nan | University of Pennsylvania | Persuasive education; WOOP (aka, mental contrasting with implementation intentions., Wish, Outcome, Obstacle, Plan); Customized Habit Tips; Raffle Financial Inc |
| NCT06341751 | Psychological Treatment for Persistent Fatigue: a Feasibility Study | COMPLETED | nan | Karolinska Institutet | Psychological treatment for persistent fatigue |
| NCT05648123 | Effectiveness of Supportive Psychotherapy Through Internet-Based Teleconsultation on Psychological and Somatic Symptoms, Neutrophil-Lymphocyte Ratio, and Heart Rate Variability in | COMPLETED | nan | Indonesia University | Supportive Psychotherapy |
| NCT06305793 | RECOVER-AUTONOMIC (IVIG): Randomized Trial of the Effect of IVIG Versus Placebo on Long COVID Symptoms | ACTIVE_NOT_RECRUITING | PHASE2 | Kanecia Obie Zimmerman | IVIG (intravenous immunoglobulin); IVIG Placebo; Coordinated Care; Usual Care |
| NCT04950725 | Covid-19 Virtual Recovery Study | COMPLETED | nan | Mayo Clinic | Strength RMT; Strength RMT and nasal breathing; Endurance RMT; Endurance RMT and nasal breathing; Low dose RMT |
| NCT05538650 | Mindfulness-based Social Work and Self-care Study: A Randomised Controlled Trial | COMPLETED | nan | Queen's University, Belfast | Mindfulness-Based Social Work and Self Care (MBSWSC); Mindfulness-Based Self-Care (MBSC) |
| NCT06189118 | Online Mindfulness-Based Cognitive Therapy vs Health Enhancement Program for Depressive Symptoms in Older Adults: a Randomized Controlled Trial | COMPLETED | nan | Lady Davis Institute | Online Mindfulness Based Cognitive Therapy or Health Education Program |
| NCT05338749 | An Open-label Trial of Computer-delivered Cognitive Training in Persons With Post-acute COVID-19 Syndrome | COMPLETED | nan | Nova Southeastern University | Cognitive Training |
| NCT05532904 | Evaluation and Comparison of Multidisciplinary Day-hospital Versus Waiting List Management of Persistent Symptoms After an Acute Episode of COVID-19 | COMPLETED | nan | Assistance Publique - Hôpitaux de Paris | Personalized multidisciplinary day-hospital intervention |
| NCT07524179 | The Effect of Therapeutic Touch on Sleep Quality and Fatigue Severity in Advanced Cancer Patients in the Palliative Care Setting: A Randomized Controlled Trial | COMPLETED | nan | Erzurum Technical University | Therapeutic Touch; Routine Palliative Care |
| NCT05631171 | COVIDAI: Feasibility Study of Adhera® Fatigue Digital Program for Patients With Long COVID-related Fatigue | COMPLETED | nan | Adhera Health, Inc. | Adhera® Fatigue Digital Program |
| NCT04833673 | The Effects of Relaxation Techniques on Pain, Fatigue and Kinesiophobia in Multiple Sclerosis Patients: A Three Arms Randomized Trial | COMPLETED | nan | Hacettepe University | PMR: Progressive Muscle Relaxation; BRT:Benson Relaxation Technique |
| NCT06016192 | Medical Rehabilitation of Patients With Long-term Post-Covid-19 Syndrome - a Comparison of Aerobic Interval and Continuous Training | COMPLETED | nan | University of Witten/Herdecke | Aerobic Exercise Training |
| NCT05922865 | Tri-service General Hospital, National Defence Medical Center, Taipei, Taiwan | COMPLETED | nan | Shang-Lin Chiang | KNEESUP smart knee assistive device + KNEESUP care APP; Healthy consulation |
| NCT04594200 | Do Peer-comparisons, Emphasis on Harms, and/or Inclusion of Viral Prescription Pad Resources Increase Responsiveness to Feedback About Antibiotic Prescribing in Primary Care (PHO T | COMPLETED | nan | Women's College Hospital | Audit and Feedback (A&F) |
| NCT07455123 | The Effect of a Self-Management Program on Fatigue, Sleep Quality, Psychological Resilience, and Occupational Balance in University Students With High Levels of Fatigue: A Randomiz | COMPLETED | nan | Hacettepe University | Self-Management Programme for Chronic Fatigue |
| NCT06251011 | Effects of Physiotherapy Via Telerehabilitation on Cardiopulmonary, Physical, and Psychological Functions in Patients With COVID-19: A Randomized Controlled Trial | COMPLETED | nan | Chulabhorn Hospital | Exercise training |
| NCT04378634 | The Influence of Epigenetic Modifications and Post-Exertional Malaise in People With Myalgic Encephalomyelitis/Chronic Fatigue Syndrome | COMPLETED | nan | Vrije Universiteit Brussel | Exercise; Mental Stress Test |
| NCT06404047 | RECOVER-ENERGIZE: A Platform Protocol for Evaluation of Interventions for Exercise Intolerance in Post-Acute Sequelae of SARS-CoV-2 Infection (PASC) | COMPLETED | nan | Duke University | Personalized Cardiopulmonary Rehabilitation; Structured Pacing; Education; Usual Care |
| NCT06575920 | Breathing Therapy for Patients With Medically Unexplained Physical Symptoms and Dysfunctional Breathing: A Pilot and Feasibility Study | COMPLETED | nan | University of Agder | Breathing excercizes |
| NCT05732285 | A Pilot Randomized Controlled Trial of A Comprehensive Cognitive and Affective Intervention for Neurocognitive Disorders (CoINTEGRATE) | COMPLETED | nan | University of Michigan | CRT; CBT; Modifiable lifestyle factors; Usual care Psychoeducation |
| NCT ID | Title | Status | Phase | Sponsor | Intervention |
|---|---|---|---|---|---|
| NCT05970731 | Directed Topical Drug Delivery for Treatment for PASC Hyposmia | COMPLETED | PHASE2 | Duke University | Beclomethasone; Placebo; Microsponge |
| NCT05965752 | RECOVER-NEURO: A Platform Protocol for Evaluation of Interventions for Cognitive Dysfunction in Post-Acute Sequelae of SARS-CoV-2 Infection (PASC) | COMPLETED | nan | Duke University | BrainHQ/Active Comparator Activity; BrainHQ; PASC CoRE; tDCS-active; tDCS-sham |
| NCT06268288 | Pilot Study--The Effects of Non-invasive Vagal Neurostimulation (nVNS) in Adolescents With Postural Orthostatic Tachycardia Syndrome (POTS) | COMPLETED | nan | Mayo Clinic | GammaCore intervention; STEPS management protocol |
| NCT05608629 | Vagus Nerve Stimulation as Treatment for Long Covid | COMPLETED | nan | Icahn School of Medicine at Mount Sinai | Transcutaneous Non-Invasive Vagus Nerve Stimulation |
| NCT05445427 | Outcomes of Treatment With Vagal Nerve Stimulation in Post-COVID Syndrome: A Pilot Study | COMPLETED | nan | Mayo Clinic | vagal nerve stimulator |
| NCT05199233 | The Benefit of Mindfulness-Based Intervention Using A Wearable Wellness Brain Sensing Device (Muse-S™) in the Treatment of Post-Covid Symptoms | COMPLETED | nan | Mayo Clinic | Muse S™ Headband system |
| NCT05200858 | Transcutaneous Electrical Nerve Stimulation For Lower Extremity In Patients With Neurogenic Pain - A Proof Of Concept Randomized Clinical Trial | COMPLETED | nan | Baylor College of Medicine | TENS - high-dose; TENS - low-dose |
| NCT05205460 | Effectiveness of a 12-week Telerehabilitation Training in People With Long COVID: A Randomized Controlled Trial | COMPLETED | nan | Tri-Service General Hospital | Home-based telerehabilitation; Education and self-exercise |
| NCT05092516 | Home-based Transcranial Direct Current Stimulation (tDCS) for Treatment of Cognitive Post-acute Sequelae of COVID-19 (PASC) | ACTIVE_NOT_RECRUITING | nan | Massachusetts General Hospital | Active tDCS; Sham tDCS |
| NCT04938687 | Pilot, Effect of Respiratory-Gated Auricular Vagal Afferent Nerve Stimulation (RAVANS) on Post-Treatment Lyme Disease Syndrome | COMPLETED | nan | Spaulding Rehabilitation Hospital | respiratory-gated auricular vagal afferent nerve stimulation (RAVANS); Sham RAVANS |
| NCT06404112 | RECOVER-SLEEP: A Platform Protocol for Evaluation of Interventions for Sleep Disturbances in Post-Acute Sequelae of SARS-CoV-2 Infection (PASC) | COMPLETED | PHASE2 | Duke University | Melatonin; Melantonin Placebo; Tailored lighting (TL) Active; Tailored lighting (TL) Placebo |
| NCT06404086 | RECOVER-SLEEP: A Platform Protocol for Evaluation of Interventions for Sleep Disturbances in Post-Acute Sequelae of SARS-CoV-2 Infection (PASC) | COMPLETED | PHASE2 | Duke University | Modafinil; Modafinil Placebo; Solriamfetol; Solriamfetol Placebo; Melatonin; Melantonin Placebo; Tailored lighting (TL) Active; Tailored lighting (TL) Placebo |
| NCT06840873 | Effectiveness of a 8-week Tele-Rehabilitative Exercise Training Program on Fatigue, Symptom Severity, and Quality of Life in Nurses With Long COVID: A Randomized Controlled Trial | COMPLETED | nan | Shang-Lin Chiang | wearable device; Healthy consulation |
| NCT07492953 | Using Enhanced External Counterpulsation to Recover Cardiovascular Function for Patient of Chronic Diseases | COMPLETED | nan | National Defense Medical Center, Taiwan | enhanced external counterpulsation |
| NCT06739668 | Microtesla Magnetic Therapy (MMT) Treatment of Post-acute Sequelae of SARS CoV-2 (PASC): Controlled Pilot Study | COMPLETED | nan | Icahn School of Medicine at Mount Sinai | Pascal device; Sham Device |
| NCT05848401 | Biosound Therapy as a Treatment for Long COVID Patients: A Randomized Pilot Trial | COMPLETED | nan | Anxiety Relief Center | Biosound Therapy System |
| NCT05679505 | Effects of Vagus Nerve Stimulation in Post-COVID-19 Syndrome: A Randomized Controlled Trial | COMPLETED | nan | Bahçeşehir University | Auricular transcutaneous vagus nerve stimulation |
| NCT05571852 | Before-and-after Study on the Impact of a Home-based Personalized Computerized Training Program on Cognitive Dysfunction Associated With Long COVID | COMPLETED | nan | Universidad Antonio de Nebrija | CogniFit's CCT Post COVID-19 |
| NCT05857124 | A Pilot Study Evaluating the Efficacy of the Vielight Neuro RX Gamma in the Treatment of Post COVID-19 Cognitive Impairment | COMPLETED | PHASE1 | Vielight Inc. | Vielight Neuro RX Gamma active device; Vielight Neuro RX Gamma sham device |
| NCT06315894 | Design and Implementation of a Supervised Computerized Active Program (SuperCAP) for Improvement of Cognitive, Emotional, and Functional Status in People With Post-COVID Syndrome. | COMPLETED | nan | Fundación FLS de Lucha Contra el Sida, las Enfermedades Infecciosas y la Promoción de la Salud y la Ciencia | SuperCAP Program |
| NCT05855369 | A Randomized Controlled Trial of Smell Training and Trigeminal Nerve Stimulation in the Treatment of COVID-related Persistent Smell Loss | RECRUITING | PHASE2; PHASE3 | Medical University of South Carolina | Trigeminal Nerve Stimulation (TNS); Active Smell Training (ST); Placebo Smell Training (PBO) |
| NCT05710770 | Double-blinded, Randomized, Sham-controlled Trial of Immunoadsorption (IA) in Patients With Chronic Fatigue Syndrome (CFS) Including Patients With Post-acute COVID-19 CFS (PACS-CFS | COMPLETED | nan | Charite University, Berlin, Germany | Immunoadsorption |
| NCT06165835 | Study on Post-Acute COVID-19 Syndrome in Improvement of COVID-19 Rehabilitated Patients by Respiratory Training | COMPLETED | nan | Tri-Service General Hospital | breathing training |
| NCT06137716 | Development and Clinical Trials of a Rehabilitation Platform to Accelerate the Recovery of Patients With COVID Neuromotor Sequelae | COMPLETED | nan | University of Valladolid | Training with a Robotic Hand Exoskeleton |
| NCT07508332 | Lung Boost Trainer Versus Incentive Spirometer on Spiro-metric Indices in Post COVID-19 Hemiplegic Cerebral Palsy Children; Randomized Controlled Trial | COMPLETED | nan | Cairo University | Lung boost trainer (LBT); Incentive Spirometer Training ( IST); Traditional Respiratory Physical Therapy Protocol (TRPT) |
| NCT07397130 | Inspiratory Muscle Pressure and Diaphragmatic Strength in Women With Long COVID-19: A Pressure Biofeedback-Guided Training Study | COMPLETED | nan | RSUP Persahabatan | Pressure Biofeedback Unit |
| NCT07553897 | Effectiveness of a Tele-Exercise Training Program on Long COVID Symptoms and Quality of Life in Patients With Long COVID | COMPLETED | nan | Tri-Service General Hospital | Telehealth exercise training program; Education and self-exercise |
| NCT05965739 | RECOVER-NEURO: A Platform Protocol for Evaluation of Interventions for Cognitive Dysfunction in Post-Acute Sequelae of SARS-CoV-2 Infection (PASC) | COMPLETED | nan | Duke University | BrainHQ/Active Comparator Activity; BrainHQ; PASC CoRE; tDCS-active; tDCS-sham |
| NCT05977166 | Influence of Hyperbaric Oxygen on Pulmonary Functions in Post Covid-19 Patients. | COMPLETED | nan | Cairo University | hyperbaric oxygen therapy; breathing exercise; medical treatment |
| NCT05841498 | A Single-blinded Sham-controlled Crossover Trial to Evaluate the Effect of Immunoadsorption on Post-Corona Virus Disease (COVID)-Syndrome | COMPLETED | nan | University Medical Center Mainz | Immunoadsorption; Sham-apheresis |
| NCT05126511 | Effects of Cranial Electrotherapy Stimulation on Anxiety of Patients After COVID-19 - a Randomised Controlled Pilot Study | COMPLETED | nan | Schön Klinik Berchtesgadener Land | Application of CES via ear clips; Sham: No application of CES via ear clips |
| NCT05793736 | A Feasibility Study of an HVR Protocol Biofeedback Training to Manage Long Covid Syndrome Symptoms | COMPLETED | nan | University of Cagliari | Biofeedback training; Treatment as usual |
| NCT05922865 | Tri-service General Hospital, National Defence Medical Center, Taipei, Taiwan | COMPLETED | nan | Shang-Lin Chiang | KNEESUP smart knee assistive device + KNEESUP care APP; Healthy consulation |
| NCT06091280 | Home-Based Respiratory Muscle Strength Training Program for Individuals With Post-COVID-19 Persistent Dyspnea | COMPLETED | nan | University of South Florida | Respiratory Muscle Strength Trainers |
| NCT06635928 | Assessing Fatigue and Attention in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Patients Before and After Treatment With Bright Light Therapy: a Prospective Randomized Contro | COMPLETED | nan | Medical University of Vienna | Bright light therapy |
| NCT05252481 | Modulation of Post-COVID-19 Fatigue Using Transcranial Direct Current Stimulation. Transcranial Direct Stimulation for Persistent Fatigue Treatment Post-COVID-19 | COMPLETED | nan | Hospital San Carlos, Madrid | Active tDCS; Sham tDCS |
| NCT06379620 | Pilot Open Label Use of the Hi-OXSR to Increase PaCO2 for the Treatment of Post COVID-19 Cognitive Dysfunction | COMPLETED | PHASE1 | University Health Network, Toronto | Hi-OxSR Sequential Rebreathing mask (oxygen concentrator) |
| NCT06933017 | Feasibility Study of the Augmented Two-Day 6-Minute Incremental Step Test and Causal Exploration Through a Directed Acyclic Graph and Structural Equation Model for Post-Exertional | COMPLETED | nan | Universitair Ziekenhuis Brussel | Portable mask for respiratory gas analysis; Cardio-pulmonary exercise test |
| NCT06189066 | Long COVID Ultrasound Trial [LOCUS Trial] | COMPLETED | nan | SecondWave Systems Inc. | Splenic Ultrasound |
| NCT07279272 | The Effect of the Human Regenerator Jet Device on the Quality of Life of Adult Individuals [HR-QoL] | COMPLETED | nan | University of Athens | Cold Atmospheric Plasma; Atmospheric Air |
| NCT05074771 | RIabilitazione di Pazienti COvid e Loro Monitoraggio IN Casa Con la pIattaforma ARc-IntEllicare - (RICOMINCIARE) | COMPLETED | nan | Camlin Ltd | ARC intellicare |
| NCT04919031 | Inspiratory Muscle Trainer Impact on Post Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) COVID-19 Hypertensive Patients With Long Term Persistent Symptoms | COMPLETED | nan | Cairo University | Inspiratory muscle trainer; diaphragmatic release |
| NCT05677932 | Bright Light Therapy for Post-COVID-19 Fatigue | COMPLETED | nan | Chinese University of Hong Kong | Bright light therapy; Dim red light therapy |
| NCT04943276 | A Novel Noninvasive Thermoregulatory Device for Postural Tachycardia | COMPLETED | nan | Stanford University | Embr Device |
| NCT05225220 | Multimodal Investigation of Post COVID-19 in Females: A Pilot Study | COMPLETED | nan | Casa Colina Hospital and Centers for Healthcare | Parasym Device (of Parasym Ltd, UK) using Transcutaneous Vagus Nerve Stimulation (t-VNS) |
| NCT05764070 | Impact of Vagus Nerve Stimulation on Post-Aerobic Activity Recovery in Post Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Patients | COMPLETED | nan | Istanbul Medipol University Hospital | non-invasive auricular vagus stimulation; Placebo Non Invasive Vagus Stimulation |
| NCT06296914 | Developing and Testing a Mobile Health System for Patients with Postural Orthostatic Tachycardia Syndrome (POTS) | COMPLETED | nan | Jami Warren | POTSapp; Waitlist Control |
| NCT05630040 | Vagus Nerve Simulation for Long-COVID-19 | COMPLETED | nan | Icahn School of Medicine at Mount Sinai | Non-invasive vagus nerve stimulation; Sham Intervention |
| NCT05043051 | Autoimmune Basis for Postural Tachycardia Syndrome | ACTIVE_NOT_RECRUITING | nan | University of Oklahoma | Vagal stimulation; Sham stimulation |
| NCT06073886 | Personalized Circuit-Based Frontoamygdala Neuromodulation for Persistent Post-Concussive Symptoms | RECRUITING | PHASE2 | University of California, Los Angeles | Active cTBS; Inactive/Sham cTBS; Imaginal exposure |
| NCT ID | Title | Status | Phase | Sponsor | Intervention |
|---|---|---|---|---|---|
| NCT05970861 | Effect of Natural Food on Gut Microbiome and Phospholipid Spectrum of Immune Cells in COVID-19 Patients | COMPLETED | nan | Asfendiyarov Kazakh National Medical University | Freeze-dried Mare Milk (Saumal) |
| NCT05473039 | OvoVid Study: Effect of a Multivitamin Supplement With Probiotic (Seidivid Ferty4®) on Oocyte Retrieval and Quality in Oocyte Donors. Double-blind Randomized Placebo-controlled Cli | COMPLETED | nan | SEID S.A. | Seidivid Ferty4; Placebo |
| NCT05524532 | Effect of Immulina Supplements on Inflammatory Biomarkers Correlated With Clinical Symptoms in Patients With Long COVID (PASC) | COMPLETED | PHASE3 | University of Mississippi Medical Center | Immulina TM; Placebo |
| NCT04795557 | Effect of ADAPT232 Supplementation on Recovery of Patients in Rehabilitation Period in Long COVID-19: a Randomized, Double-blind, Placebo-controlled Trial | COMPLETED | PHASE2; PHASE3 | Swedish Herbal Institute AB | ADAPT-232 oral solution; Placebo oral solution |
| NCT04604704 | Pilot Study Into Low Dose Naltrexone (LDN) and Nicotinamide Adenine Dinucleotide (NAD+) for Treatment of Patients With Post-COVID-19 Syndrome (Long-COVID19) | COMPLETED | PHASE2 | AgelessRx | Naltrexone; NAD+ |
| NCT05618574 | Nitrite Supplementation to Mitigate Fatigability and Increase Function in Long COVID Patients | COMPLETED | PHASE2 | VA Office of Research and Development | 140 ml per day of Beet-It nitrate beverage (James White Drinks Ltd., Ipswich, UK); 210 ml of nitrate-depleted placebo |
| NCT06974058 | Evaluation of a Quercetin/Curcumin-Based Supplement for Mild to Moderate Long COVID-19 Symptoms: A Pragmatic, Interventional Clinical Study. | COMPLETED | nan | Liaquat University of Medical & Health Sciences | Nasafytol® (Quercetin/Curcumin Supplement) |
| NCT05703074 | The Efficacy and Safety of a Mental Intervention Program vs. Usual Care and Nicotinamide Riboside (NR) vs. Placebo for Improving Health-related Quality of Life in Long Covid: A 2 x | ACTIVE_NOT_RECRUITING | PHASE2 | University Hospital, Akershus | Nicotinamide Riboside (NR); Mind-body reprocessing therapy (MBRT); Care as usual; Placebo |
| NCT05728918 | Effectiveness of Antrodia Cinnamomea Mycelia on Improving Immune Response in Subhealth People | COMPLETED | nan | Greenyn Biotechnology Co., Ltd. | Antrodia cinnamomea mycelia; Placebo |
| NCT04828668 | A Single-Blind, Randomized, Placebo Controlled, Study to Evaluate the Benefits and Safety of Endourage Targeted Wellness Formula C™ Sublingual Drops in People With Post -Acute COVI | COMPLETED | nan | Endourage, LLC | Targeted Wellness Formula C™ Sublingual Drops - 1200mg - 30 mL (Formula C) |
| NCT05311852 | Effects of Palmitoylethanolamide Co-ultramicronized With Luteoline (Pea-lut) on Frontal Lobe Functions and GABAergic Transmission in Long Covid Patients. An 8-week Randomized Contr | COMPLETED | nan | Department of Neurorehabilitation, Hospital of Vipiteno-Sterzing (BZ) Italy | palmitoylethanolamide co-ultramicronized with antioxidant flavonoid luteolin (PEA-LUT); Placebo |
| NCT06535165 | Effect of 14-day Red Beetroot Juice Intake on Physical Function, Gut Microbiota Composition, and Systemic Inflammation in Adults With Long COVID-19 | COMPLETED | nan | Catholic University of the Sacred Heart | Red Beetroot Juice; Placebo |
| NCT05080244 | Evaluation of the Efficacy of Probiotics Taken During the Acute Phase of COVID-19 to Reduce the Occurrence of Long COVID | COMPLETED | nan | Centre de recherche du Centre hospitalier universitaire de Sherbrooke | Probiotics; Placebo |
| NCT04381780 | Treatment of Fibromyalgia With a Unique Polypeptide Nutritional Support | COMPLETED | nan | Practitioners Alliance Network | Recovery Factors |
| NCT04751669 | Efficacy of Micronutrient Dietary Supplementation in Reducing Hospital Admissions for COVID-19: A Double-blind, Placebo-controlled, Randomized Clinical Trial | COMPLETED | nan | Fundació Institut Germans Trias i Pujol | Vitamin and trace elements; Placebo |
| NCT06437210 | Evaluation of Treatment With Viusid in Post-COVID-19 Syndrome | COMPLETED | nan | Catalysis SL | Viusid Oral Solution; Placebo |
| NCT05531019 | COVID-19 Sequelae: Treatment and Monitoring of Persistent Symptoms, a Decentralized Approach Focus on the Patient. Use of Dietary Supplement Based on Sea Urchin Eggs With Echinochr | COMPLETED | nan | Fernando Saldarini | Echinochrome A; Control |
| NCT06496087 | Evaluation of DEPREXIL Treatment in Patients With Clinical Depression Through Psychological and Neuroendocrine Assessment | COMPLETED | nan | Catalysis SL | DEPREXIL |
| NCT06108297 | Effect of Low-dose Lithium Therapy on Long COVID Symptoms: an Open-label, Dose-finding Study. | COMPLETED | PHASE1 | State University of New York at Buffalo | Lithium |
| NCT05836402 | Low-Carbohydrate Dietary and Lifestyle Interventions for the Management of Long COVID-19 Syndrome: A Prospective and Interventional Randomized Controlled Pilot Study | COMPLETED | nan | University of Southern California | Low carbohydrate diet intervention |
| NCT05178225 | Spa Rehabilitation, Antioxidant and Bioenergetic Supportive Treatment of Patients With Post-Covid-19 Syndrome | COMPLETED | nan | Comenius University | ubiquinol (reduced coenzyme Q10); mountain spa rehabilitation; 2x14 ml of peripheral blood collected in a tube with anticoagulant |
| NCT06013072 | The Effects of 3-month Supplementation With a Pre-probiotic on Patient- and Clinician-reported Outcomes, and Brain Tissue Metabolism in Patients With Post-covid Fatigue Syndrome: a | COMPLETED | nan | University of Novi Sad, Faculty of Sport and Physical Education | Dietary Supplement: Experimental; Dietary Supplement: Placebo |
| NCT06620406 | Pilot Study of Synbiotic Therapy for Neuropsychiatric PASC | COMPLETED | nan | Columbia University | Synbiotic IVS-1; Maltodextrin |
| NCT04741841 | Effect of Probiotic Food Supplement "GutMagnific™" in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS), Also Known as Post-viral Fatigue Syndrome, and Comorbid | COMPLETED | nan | ImmuneBiotech Medical Sweden AB | GutMagnific™ H.; GutMagnific™ L.; Placebo |
| NCT06695910 | Modulation of the Brain Fog Scale by Eicosapentaenoic Acid Monoglycerides (MAG-EPA) in Volunteers Who Reported Suffering From Haze or Mental Fatigue on a Regular Basis. Exploratory | RECRUITING | PHASE4 | Samuel Fortin | Monoglyceride Eicosapentaenoic acid (omega-3); Sunflower Oil |
| NCT06423586 | Positive Effect of Lecithin-based Delivery Form of Curcuma and Boswellia Extracts on Post-acute COVID-19 Irritable Bowel Syndrome. Two Cohorts of an Open-label Study. | COMPLETED | nan | Azienda di Servizi alla Persona di Pavia | Curcuma longa and Boswellia serrata extracts |
| NCT06064838 | Effects of Cacao Flavonoids in Long COVID-19 Patients with Chronic Fatigue (FLALOC) | COMPLETED | nan | Guillermo Ceballos Reyes | Flavonoids |
| NCT05630339 | Efficacy and Security of the Magnesium and Vitamin D Combination as Adjuvant Treatment of Post-COVID Syndrome. A Randomised Double-blind Clinical Trial | COMPLETED | nan | Coordinación de Investigación en Salud, Mexico | Magnesium chloride; Vitamin D; Inert placebo |
| NCT05356936 | Pilot Study of Vitamin K2 (MK-7) and Vitamin D3 Supplementation and the Effects on PASC Symptomatology and Inflammatory Biomarkers | COMPLETED | nan | University Hospitals Cleveland Medical Center | Vitamin K2 (MK-7); Vitamin D3 |
| NCT07544186 | Effect of a Non-pharmacological Intervention (Nutritional Therapy and Pulmonary Rehabilitation) on Endothelial Function, Body Composition, and Physical Functionality in Recovered C | COMPLETED | nan | Instituto Nacional de Enfermedades Respiratorias | L-citrulline supplementation |
| NCT04301609 | Randomized, Comparative, Double-blind, and Placebo-controlled Clinical Trial to Assess the Improvement of Fatigue, Sleep, Anxiety / Depression, Neurovegetatives Alterations and Qua | COMPLETED | nan | Vitae Health Innovation | Active; Placebo |
| NCT06511050 | Investigating the Effects of Lumbrokinase in Adults With Long Covid, Post-treatment Lyme Disease Syndrome, and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome | RECRUITING | PHASE1; PHASE2 | Icahn School of Medicine at Mount Sinai | Lumbrokinase |
| NCT04813718 | Post COVID-19 Syndrome: A Pilot Study to Explore the Gut-lung Axis | ACTIVE_NOT_RECRUITING | nan | Medical University of Graz | Omni-Biotic Pro Vi 5; Placebo |
| NCT06967428 | Effectiveness of Metabolic Modulation in Treating Post-vaccination Syndrome: A Prospective Study | NOT_YET_RECRUITING | PHASE2 | Independent Medical Alliance | Combined metabolic modulator; Rice Protein Powder with Vitamin C |
| NCT05705648 | Nutritional Management of Post COVID-19 Cognitive Symptoms | RECRUITING | nan | University of Alberta | medium chain triglyceride oil; Safflower oil |
| NCT05924646 | CAlgary SAlt for Postural Orthostatic Tachycardia Syndrome Study | RECRUITING | nan | University of Calgary | Sodium Chloride Capsules; Microcystalline Cellulose Capsules |
| NCT06166030 | EFFECTS OF WHEY PROTEIN SUPPLEMENTATION ON CARDIOPULMONARY, MUSCLE AND IMMUNOHEMATOLOGICAL RESPONSES OF POST-COVID-19 PATIENTS. | UNKNOWN | PHASE3 | Federal University of São Paulo | Nutritional blend (ImmuneRecov). |
| NCT03773003 | Pathophysiology of Cancer Related Fatigue (CRF) and Chronic Fatigue (CFS/ME) by Lipidomics, Metabolomics, Microbiome and Exome Analysis and Investigation of Clinical Improvement Un | RECRUITING | nan | Universität des Saarlandes | Probiotics; Placebo |
| NCT07009691 | Heart Rate Variability as an Autonomic Marker of Improvement in ME/CFS in a Hydrogen Water Treatment Study | RECRUITING | nan | Stony Brook University | Hydrogen water which is prepared from an OTC supplement. |
| NCT07397910 | Clinical Trial to Analyze the Effectiveness of a Natural Compound on Chronic Immune-mediated Inflammatory Status in Subjects Who Have Had SARS-CoV-2 Infection. | NOT_YET_RECRUITING | nan | Universidad Católica San Antonio de Murcia | Experimental Product; Control placebo; Physical exercise; No Physical Exercise |
| NCT06992414 | Exploring Creatine Supplementation for Improved Exercise Capacity and Reduced Fatigue in Long COVID-19: A Randomized Controlled Trial | NOT_YET_RECRUITING | nan | University of Calgary | Creatine monohydrate |
| NCT06235177 | Psychoneuromentalism Disorder: A Condition Resulting From Behavioral Impairments, Neurodiversity, and Neurobehavioral Dysfunctions Related to the Mental and Emotional State of a Pe | NOT_YET_RECRUITING | EARLY_PHASE1 | The Essence of Integrative Health and Medicine Practice | Decompartmentalization Framework; Liquid Herbal TInctures; Mental Imagery; Clinical Yoga; Dietary Supplements; Applied Relaxation; Pain Relaxation Techniques; C |
| NCT05813899 | Efficacy of Lactobacillus Paracasei PS23 for Patients With Post-COVID-19 Syndrome | TERMINATED | nan | Mackay Memorial Hospital | PS23 heat-treated |
| NCT07312409 | Does Taurine Supplementation Improve Vascular Function and Orthostatic Responses in Long COVID? | NOT_YET_RECRUITING | nan | York University | Taurine supplementation |
| NCT06227273 | Hydrogen Water Dosing Study for ME/CFS and Chronic Fatigue | UNKNOWN | nan | Stony Brook University | Hydrogen water |
| NCT04592354 | Anhydrous Enol-Oxaloacetate (AEO) on Improving Fatigue in Post-COVID-19 Survivors | UNKNOWN | nan | Terra Biological LLC | Oxaloacetate Medical Food/Dietary Supplement |
| NCT05454683 | Effect of Melatonin Plus Zinc Supplementation on Fatigue, Pain, Sleep Disturbances, Anxiety and Depression, and Autonomic Dysfunction in ME/CFS: a Randomized, Double-blind, Placebo | UNKNOWN | nan | Laboratorios Viñas, S.A. | melatonin plus zinc; isomaltose and magnesium stearate |
| NCT04947488 | Evaluation of the Effects of Treatment With Bioarginin C on Physical Exhaustion , Systemic Inflammatory State and Endothelial Function in Adult Subjects Belonging to the Post-Covid | UNKNOWN | nan | University of Milan | Bioarginina C |
| NCT05874089 | The Role of VSL#3® in the Treatment of Fatigue and Other Symptoms in Long Covid-19 Syndrome: a Randomized, Double-blind, Placebo-controlled Study (DELong#3) | UNKNOWN | nan | Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico | VSL#3®; Placebo |
| NCT05975034 | Investigation of the Use of a Probiotic Supplement in People With Long COVID | UNKNOWN | nan | Sheffield Hallam University | Probiotic; Placebo |
| NCT ID | Title | Status | Phase | Sponsor | Intervention |
|---|---|---|---|---|---|
| NCT06476496 | Pain Relief With Integrative Medicine (PRIMe)?: Feasibility of Acupuncture for Long COVID | COMPLETED | nan | University of Washington | Acupuncture |
| NCT06208163 | Psychoneuroimmunology as a Framework for Studying the Effects of Chiropractic Care in a Population With High Central Adiposity: a Pilot Trial | COMPLETED | nan | Life University | Chiropractic |
| NCT06267326 | Case Series of Post Covid 19 Rhino Orbito Cerebral Mucormycosis in Egypt | COMPLETED | PHASE1; PHASE2 | Nasser Institute For Research and Treatment | debridment |
| NCT04842448 | Hyperbaric Oxygen for Treatment of Long COVID Syndrome; A Randomized, Placebo-Controlled, Double-Blind, Phase II Clinical Trial | COMPLETED | PHASE2 | Karolinska University Hospital | Hyperbaric oxygen; Sham treatment |
| NCT05389592 | Treatment of COVID-19 Post-acute Cognitive Impairment Sequelae (PASC) With Portable Brain Stimulation: a Double-blind, Randomized-controlled Trial | COMPLETED | nan | University of Sao Paulo | Active tDCS and cognitive training; Sham tDCS and cognitive training |
| NCT04396652 | Comparison of Adductor Canal Block, Peri-articular Injection or Infiltration Between Popliteal Artery and Posterior Knee Capsule (IPACK) With Adductor Canal Block in Total Knee Art | COMPLETED | nan | Tanta University | Adductor canal block (ACB) group; Peri-articular injection group; Adductor canal block and IPACK block group |
| NCT04740736 | Cardiovascular Analysis of Post-exertional Malaise | COMPLETED | nan | Icahn School of Medicine at Mount Sinai | Saline Infusion |
| NCT07320833 | Postoperative Analgesic Efficacy of Ultrasound Guided Para-sartorial Compartments (PASC) Block Versus Combined Femoral-Sciatic Nerve Block in Patients Undergoing Total Knee Arthrop | COMPLETED | nan | Ain Shams University | Ultrasound-Guided Femoral Nerve Block plus Sciatic Nerve Block; Ultrasound-Guided Para-sartorial Compartments Block |
| NCT06795750 | The Effect of Neural Therapy on Heart Rate Recovery, Cardiac Parameters and Pain in Fibromyalgia: a Randomized Controlled Trial | COMPLETED | nan | Uşak University | neural therapy; Exercise |
| NCT04158427 | Intestinal Microbiota and Chronic Fatigue Syndrome. Effect of Fecal Transplant on Health Related Quality of Life of the Patients With Chronic Fatigue Syndrome | COMPLETED | nan | Tampere University Hospital | Faecal transplantation; Placebo faecal transplantation |
| NCT05954325 | Extracorporal Apheresis Hannover Medical School Study in Post COVID-19 Patients | COMPLETED | nan | Hannover Medical School | Immunoadsorption vs. sham immunoadsorption |
| NCT04996212 | Study of the Effectiveness of a Cardiorespiratory Telerehabilitation Program in Persistent COVID-19 Patients. Randomized Clinical Trial. | COMPLETED | nan | University of Valencia | Walking APP Group; Functional APP group |
| NCT06124625 | Effects of Rehabilitation Combined With a 12-week Maintenance Program Compared to Rehabilitation Alone in Post-COVID-19 - a Randomized, Controlled Trial. | ACTIVE_NOT_RECRUITING | nan | Schön Klinik Berchtesgadener Land | Rehabilitation combined to a digital maintenance program; Rehabilitation without maintenance program |
| NCT05445830 | Physiological Characterization of Functional Limitations and Exercise Intolerance in Post-COVID Patients | ACTIVE_NOT_RECRUITING | nan | Karolinska Institutet | High-Intensity-Interval-Exercise; Moderate-Intensity-Continuous-Exercise; Strength training; Baseline assessment; 1 year follow-up |
| NCT07374562 | Effect of Stellate Ganglion Block Treatment on Long COVID Symptoms: A Single-Blind, Single-Center Randomized Controlled Trial (STAR-CO) | RECRUITING | nan | Centre intégré universitaire de santé et de services sociaux de la Mauricie-et-du-Centre-du-Québec | Stellate Ganglion Block (Bupivacaine); placebo saline injection |
| NCT06865222 | Variable Pulse Transcranial Magnetic Stimulation for Treatment of Post COVID Syndrome | RECRUITING | nan | Mayo Clinic | Electromagnetic Brain Pulsing Variable Pulse Protocol (EMBP) - 2 weeks; Electromagnetic Brain Pulsing Variable Pulse Protocol (EMBP) - 4 weeks |
| NCT06554834 | Effects of Three Therapeutic Sessions of the Fourth Ventricle Compression Technique and Rib Raising Osteopathic Technique on Autonomic Nervous System Activity Measured by Heart Rat | RECRUITING | nan | SomaticMed | CV4 + RR; CV4; sham ultrasound transducer; Ultrasound Transducer Sham Procedure; EEG/HRV/RSA (Electroencephalography, Heart Rate Variability, Respiratory Sinus |
| NCT05833217 | Obesity, Insulin Resistance, and PASC: Persistent SARS-CoV-2 Infection and Inflammation in Human Adipose Tissue | RECRUITING | nan | Stanford University | Adipose Tissue Biopsy; Steady State Plasma Glucose (SSPG) Test |
| NCT06055270 | Stellate Ganglion Block With Lidocaine for the Treatment of COVID-19-Induced Parosmia: Double-Blinded, Placebo-Controlled Randomized Clinical Trial | UNKNOWN | PHASE3 | London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's | Stellate Ganglion Block; Placebo |
| NCT05493605 | Cardiac Involvement in Wilson's Disease | RECRUITING | nan | Fondation Ophtalmologique Adolphe de Rothschild | Delivery of a long-term Holter 21 days Or placement of an implantable holter from the outset so syncope |
| NCT06095297 | Technique to Enable Return-to-Work by Employees With Long COVID Brain Fog | RECRUITING | nan | University of Alabama at Birmingham | Processing Speed Training; In-lab Instrumental Activities of Daily Living Training; In-lab Brain Health Training; Transfer Package; Follow Up Phone Calls; Vocat |
| NCT07285707 | Acupuncture for Long COVID - A Pragmatic Pilot Study | RECRUITING | nan | Southern California University of Health Sciences | Acupuncture |
| NCT07523113 | Brain Training for Chronic, Post-viral, Brain Fog: Study A | NOT_YET_RECRUITING | nan | University of Alabama at Birmingham | Processing Speed Training; In-session Instrumental Activities of Daily Living Training; Transfer Package; Follow Up Phone Calls; Trans-auricular Vagus Nerve Sti |
| NCT06570239 | Efficacy of Spa Management (Hydrokinesitherapy and Crenobalneotherapy) Compared With Usual Management of People With Post-Covid-19 Conditions: a Randomized, Open-label Clinical Tri | NOT_YET_RECRUITING | nan | Central Hospital, Nancy, France | intervention group |
| NCT06953661 | Ultrasound Guided Stellate Ganglion Block in Postural Tachycardia Syndrome: A Randomized Double Blind Sham Placebo-controlled Pilot Study | NOT_YET_RECRUITING | nan | Stanford University | Stellate ganglion block; Sham injection of saline; Ropivacaine; Normal saline |
| NCT06534164 | Telerehabilitation of Balance Clinical and Economic Decision Support System | NOT_YET_RECRUITING | nan | University College, London | Full/High Tech Telerehabilitation decision support system; Basic/Low Tech Telerehabilitation decision support system; OTAGO Home exercise program; Vestibular re |
| NCT05693064 | The Impact of Chiropractic on Fatigue & the Autonomic Nervous System in Adults With Long COVID-19: a Waitlist-controlled, Single-blind, One-way Crossover, Pilot Trial | SUSPENDED | nan | Life University | wait-list; chiropractic adjustments |
| NCT05855356 | The Long-CoviD Patients Causal Diagnosis and Rehabilitation Randomized Feasibility Controlled Trial in Patients With Dysautonomia: the LoCoDiRe-Dys Study | UNKNOWN | nan | Evangelismos Hospital | Rehabilitation; Standard of Care |
| NCT05669261 | A PILOT STUDY ON RESEARCH TREATMENT OF LONG COVID POST-ACUTE SEQUELAE OF SARS CoV-2 INFECTION ("PASC") USING ATCell™ | UNKNOWN | PHASE1 | American CryoStem Corporation | Adipose Tissue Harvest; ATCell |
| NCT05556733 | Faecal Microbiota Transplantation for Post-acute COVID-19 Syndrome: a Pilot Open-label Study | UNKNOWN | nan | Chinese University of Hong Kong | Faecal Microbiota Transplantation |
| NCT05668039 | Enhanced External Counterpulsation (EECP/ECPT) to Treat Long-COVID-19 Fatigue - a Randomized Controlled Trial | UNKNOWN | nan | Sheba Medical Center | Enhanced external counterpulsation |
| NCT05722730 | Effects of Pilates in Patients With Post- -COVID-19 Syndrome: Controlled and Randomized Clinical Trial | UNKNOWN | nan | Michele de Aguiar Zacaria | Pilates Exercises |
| NCT ID | Title | Status | Phase | Sponsor | Intervention |
|---|---|---|---|---|---|
| NCT05212610 | Assessing Safety of COVID-19 mRNA Vaccine Administration in the Setting of a Previous Adverse Reaction | COMPLETED | PHASE4 | University of Michigan | Pfizer-BioNTech mRNA COVID-19 vaccine; Moderna mRNA COVID-19 vaccine |
| NCT04920916 | Safety and Efficacy of the Treatment of Hospitalized Patients With COVID 19 Infection With an Inhibitor of IL-4 and IL-13 Signaling: A Phase IIa Trial | COMPLETED | PHASE2 | University of Virginia | Dupilumab; Placebo |
| NCT03356821 | Adult Mesenchymal Stromal Cells to Regenerate the Neonatal Brain: the PASSIoN Trial (Perinatal Arterial Stroke Treated With Stromal Cells IntraNasally) | COMPLETED | PHASE1; PHASE2 | UMC Utrecht | Mesenchymal Stem Cells |
| NCT05126563 | A Randomized, Double-blinded, Single-center, Phase 2 Efficacy, and Safety Study of Allogeneic HB-adMSCs for the Treatment of Patients With Chronic Post-COVID-19 Syndrome. | COMPLETED | PHASE2 | Hope Biosciences Research Foundation | HB-adMSCs (allogeneic); Placebo |
| NCT04880161 | A Randomized, Double-Blinded, Placebo-Controlled Phase I Study to Evaluate the Safety and Efficacy of Ampion in Patients With Prolonged Respiratory Symptoms Due to COVID-19 (Long C | COMPLETED | PHASE1 | Ampio Pharmaceuticals. Inc. | Ampion; Placebo |
| NCT06524739 | Double-blind, Randomized, Placebo-controlled Phase 3 Study Evaluating Efficacy and Safety of IgPro20 (Subcutaneous Immunoglobulin, HIZENTRA®) in Post-COVID-19 Postural Orthostatic | TERMINATED | PHASE3 | CSL Behring | IgPro20; Placebo |
| NCT05682560 | A Randomized Controlled Phase IIa, Two-arm Study to Assess the Safety and Efficacy of Human Umbilical Cord Blood (RegeneCyte) Infusion in Patients with Post-COVID Syndrome | COMPLETED | PHASE2 | StemCyte, Inc. | REGENECYTE; Placebo |
| NCT06441955 | Covid-19 Long Haul Syndrome: Undiagnosed Disorder Post Covid-19 Alternative Treatment Study. | RECRUITING | PHASE4 | Well- Konnect Healthcare Services and Research Firm | Ritonavir-Boosted Nirmatrelvir (Paxlovid); Physiological Evaluation; Moderna COVID-19 Vaccine; Biopsychological; Behavioral (e.g., Psychotherapy, Lifestyle Coun |
| NCT05758480 | Characterization of the Immunometabolic Signature in Long COVID-19. | COMPLETED | nan | University Hospital, Angers | Blood sample (at inclusion and 6 months later); Patient questionnaires (at inclusion and 6 months later) |
| NCT07184385 | A Multicenter, Double-blind, Randomized, Placebo-controlled, Two-arm Phase III Study to Assess the Efficacy of Human Umbilical Cord Blood (REGENECYTE) Infusion in Reducing Fatigue | NOT_YET_RECRUITING | PHASE3 | StemCyte, Inc. | REGENECYTE; Placebo |
| NCT07021794 | Effectiveness of Treating Post-COVID-19 Conditions (Long COVID) With the SARS-CoV-2 Specific Monoclonal Antibody, Sipavibart | RECRUITING | PHASE2 | Nancy Klimas | Placebo; Sipavibart |
| NCT03365414 | A Double Blind Randomized Controlled Crossover Study to Systematically Assess the Efficacy and Safety of Intravenous Albumin Infusions in Severe Postural Orthostatic Tachycardia Sy | WITHDRAWN | PHASE3 | University of Alberta | Albumin (Human) 5%, USP; Normal Saline 0.9% Infusion Solution Bag |
| NCT06666153 | A Clinical Study Evaluating the Safety, Tolerability, and Initial Efficacy of Therapeutic Immunological Agent for EBV Lymphoproliferative Diseases | NOT_YET_RECRUITING | PHASE1 | West China Hospital | EBV immunological agent |
| NCT04363606 | Chronic Fatigue Etiology and Recovery in Covid-19 Patients : the Role of Fatigability and Stay in Intensive Care | TERMINATED | nan | Centre Hospitalier Universitaire de Saint Etienne | Questionnaires; blood test; Maximal effort test; actigraphy; Neuromuscular evaluation; stool analysis; food diary |
| NCT05116761 | Bone Marrow Mesenchymal Stem Cell Derived Extracellular Vesicles Infusion Treatment for Post-Acute and Chronic Post-COVID-19 Syndrome: A Phase I/II Clinical Trial | WITHDRAWN | PHASE1; PHASE2 | Direct Biologics, LLC | Bone Marrow Mesenchymal Stem Cell Derived Extracellular Vesicles; Saline |
| NCT04507477 | Ex-vivo Delivery of Rituximab to Prevent Post-transplant Lymphoproliferative Disease in Epstein-Barr Virus Mismatch Lung Transplant Recipients: A Pilot Trial | UNKNOWN | PHASE1; PHASE2 | University Health Network, Toronto | Rituximab |
| NCT05719012 | Efficacy and Safety of Umbilical Cord Mesenchymal Stem Cells in the Treatment of Long COVID-19: a Randomized, Double-blind, Parallel-controlled Study | WITHDRAWN | PHASE2 | Shanghai East Hospital | UC-MSCs |
| NCT04909892 | A Phase 2a Study of Intravenous Allogeneic Adipose-Derived Mesenchymal Stem Cells to Treat Post COVID-19 "Long Haul" Pulmonary Compromise | WITHDRAWN | PHASE2 | Sorrento Therapeutics, Inc. | COVI-MSC |
| NCT06141317 | Tissue Regeneration and Function Recovery in Patients With Parkinson's Disease Using Allogenic Pluripotent Stem Cells Isolated From Adipose Tissue (PASCs): A Randomized Phase | UNKNOWN | PHASE1; PHASE2 | ClusterXStem-Costa Rica | PASC transplantation (25 million PASCs/patient); Control |
| NCT05346120 | Post-Acute COVID-19, Inflammation, and Depression | WITHDRAWN | PHASE2 | Sean Savitz | allogeneic marrow stromal cells (MSCs) |
| NCT04992247 | A Phase 2A Randomized, Placebo-Controlled Study of Intravenous Allogeneic Adipose-Derived Mesenchymal Stem Cells to Treat Post COVID-19 "Long Haul" Pulmonary Compromise | WITHDRAWN | PHASE2 | Sorrento Therapeutics, Inc. | COVI-MSC; Placebo |
| NCT03849326 | Chronic Fatigue Etiology in Intensive Care Unit Survivors: the Role of Neuromuscular Function | WITHDRAWN | nan | Centre Hospitalier Universitaire de Saint Etienne | Questionnaires; blood test; Maximal effort test; actigraphy; Neuromuscular evaluation |
| NCT05669261 | A PILOT STUDY ON RESEARCH TREATMENT OF LONG COVID POST-ACUTE SEQUELAE OF SARS CoV-2 INFECTION ("PASC") USING ATCell™ | UNKNOWN | PHASE1 | American CryoStem Corporation | Adipose Tissue Harvest; ATCell |
| NCT06156241 | Long COVID: Cord Tissue-Derived Mesenchymal Stromal Cells for Persistent NeuroInflammatory Symptoms | UNKNOWN | PHASE1 | Charles Cox | Stem Cell |
| NCT05808400 | Clinical Study of the Safety and Efficacy of Umbilical Cord Mesenchymal Stem Cell Exosomes in Treating Chronic Cough After COVID-19 Infection | UNKNOWN | EARLY_PHASE1 | Huazhong University of Science and Technology | MSC-derived exosomes |
| NCT ID | Title | Status | Phase | Sponsor | Intervention |
|---|---|---|---|---|---|
| NCT06441955 | Covid-19 Long Haul Syndrome: Undiagnosed Disorder Post Covid-19 Alternative Treatment Study. | RECRUITING | PHASE4 | Well- Konnect Healthcare Services and Research Firm | Ritonavir-Boosted Nirmatrelvir (Paxlovid); Physiological Evaluation; Moderna COVID-19 Vaccine; Biopsychological; Behavioral (e.g., Psychotherapy, Lifestyle Coun |
| NCT05238415 | ASAP - Assisted Immediate Augmented Post-/Long-COVID Plan | COMPLETED | nan | Prof. Dr. Sonia Lippke | Psychological and Physiological Assessments |
| NCT05178225 | Spa Rehabilitation, Antioxidant and Bioenergetic Supportive Treatment of Patients With Post-Covid-19 Syndrome | COMPLETED | nan | Comenius University | ubiquinol (reduced coenzyme Q10); mountain spa rehabilitation; 2x14 ml of peripheral blood collected in a tube with anticoagulant |
| NCT04527198 | Brainstem Dysfunction in Ventilated and Deeply Sedated COVID-19 Critically Ill Patients: a Prospective Observational Study | COMPLETED | nan | Assistance Publique - Hôpitaux de Paris | Brainstem Responses Assessment Sedation Score (BRASS); Electroencephalogram with EKG lead |
| NCT05684588 | Post-COVID-19 Sequelae: Osteonecrosis of Femoral Head | COMPLETED | nan | FROM- Fondazione per la Ricerca Ospedale di Bergamo- ETS | Magnetic Resonance |
| NCT07559994 | Diagnostic and Clinical Management of Non-Obstructive Myocardial Ischemia in Patients With Long Covid-19 Syndrome and New Onset Chest Pain: the Long Covid-19 INOCA Trial | ACTIVE_NOT_RECRUITING | nan | Fundacion Investigacion Interhospitalaria Cardiovascular | Coronary functional test |
| NCT05375968 | Mechanism of Glucose-dependent Insulinotropic Polypeptide (GIP) on Splanchnic Venous Capacitance in Postural Tachycardia Syndrome | RECRUITING | PHASE2 | Vanderbilt University Medical Center | Measurement of Splanchnic venous capacitance(SVC)done at Baseline and after 90 min of 75 g glucose in Healthy Controls POTS patients; Measurement of Splanchnic |
| NCT04935307 | Central Processing of Odour Stimuli in Patients With Multi-systemic Functional Somatic Disorder, Multiple Chemical Sensitivityor Post Covid Compared to Healthy Controls - the Pilot | ACTIVE_NOT_RECRUITING | nan | University of Aarhus | MRI and paraclinical tests |
| NCT07189936 | Mechanism of Isolevuglandin-Protein Adduct Formation in Persistent Immune Activation in Long COVID POTS | RECRUITING | PHASE2 | Vanderbilt University Medical Center | To Measure levels of circulating monocyte/ T cell doublets at Baseline; To measure levels of circulating monocyte/ T cell doublets after 28 days of 2 HOBA treat |
| NCT06311435 | Utilizing Novel Blood RNA Biomarkers as a Diagnostic Tool in the Identification of Long COVID-19 | RECRUITING | nan | MaxWell Clinic, PLC | RNA Biomarker Blood Test |
| NCT07343856 | Development of a Personalized Alternative Non-invasive Rapid Diagnostic Test for SARS-CoV-2 in Patients With Long COVID | ENROLLING_BY_INVITATION | nan | Oncology Center,Ministry Of Heath,Uzbekistan | Electrodiagnostic Bioelectrical Assessment |
| NCT06876948 | STUDY of NEUROLOGICAL COMPLICATIONS of LONG COVID-19 in CHILDREN and ADOLESCENTS; NEUROPSYCHIATRIC, ELECTROENCEPHALOGRAPHIC and NEURORADIOLOGICAL INVESTIGATIONS | RECRUITING | nan | Azienda Ospedaliero, Universitaria Pisana | Psychological tests, EEG, Magnetic Resonance |
| NCT07455994 | Dysautonomia in Children With Type 1 Diabetes: "DysDiab" Single-center Study | RECRUITING | nan | Centre Hospitalier Universitaire de Saint Etienne | Neurocoach® and Sudoscan® |
| NCT05421208 | Cardiovascular Autonomic and Immune Mechanism of Post COVID-19 Tachycardia Syndrome | RECRUITING | nan | Vanderbilt University Medical Center | Levels of inflammatory cytokine ( IL-6) in post-COVID-19 POTS and controls; Levels of inflammatory cytokine ( IL-6) in controls; Effect on inflammation after ch |
| NCT05400174 | Effects of Blood Pressure on Cognition and Cerebral Blood Flow in Parkinson Disease | RECRUITING | nan | University of California, San Diego | Tilt table (upright position) |
| NCT05833217 | Obesity, Insulin Resistance, and PASC: Persistent SARS-CoV-2 Infection and Inflammation in Human Adipose Tissue | RECRUITING | nan | Stanford University | Adipose Tissue Biopsy; Steady State Plasma Glucose (SSPG) Test |
| NCT06292377 | Better Understanding of Fatigue After STroke | RECRUITING | nan | Brugmann University Hospital | ECG; Transthoracic echography (TTE); Blood sampling |
| NCT05748015 | Definition of Autonomic Nervous System Involvement in Patients With Relapsing-remitting and Primary Progressive Multiple Sclerosis | RECRUITING | nan | Istituti Clinici Scientifici Maugeri SpA | quantification of sensory and autonomic small nerve fibers by punch skin biopsy; Cardiovascular Reflexes testing; Administration of clinical scales evaluating a |
| NCT06027255 | Long COVID Immune Profiling | RECRUITING | nan | Vanderbilt University Medical Center | IL-6; cytokines (IL-17, and IFN-ɣ); Compass 31 |
| NCT07259902 | Mapping the Neuroplasticity of Patients Affected by Chronic Temporomandibular Disorders on fMRI | NOT_YET_RECRUITING | nan | University of Milan | fMRI |
| NCT04855266 | A Randomized, Controlled, Double-Blind, Placebo-Controlled Study Evaluating the Efficacy of Intravenous Iron Sucrose in Patients With Non-anemic Iron Deficiency and Postural Orthos | WITHDRAWN | PHASE2 | Mayo Clinic | Sucrose; Placebo; Tilt Table Test |
| NCT06235177 | Psychoneuromentalism Disorder: A Condition Resulting From Behavioral Impairments, Neurodiversity, and Neurobehavioral Dysfunctions Related to the Mental and Emotional State of a Pe | NOT_YET_RECRUITING | EARLY_PHASE1 | The Essence of Integrative Health and Medicine Practice | Decompartmentalization Framework; Liquid Herbal TInctures; Mental Imagery; Clinical Yoga; Dietary Supplements; Applied Relaxation; Pain Relaxation Techniques; C |
| NCT05445531 | Low-field Magnetic Resonance Imaging to Assess Changes in Pulmonary Function Parameters in Confirmed Pediatric SARS-CoV-2 Infection | UNKNOWN | nan | University of Erlangen-Nürnberg Medical School | Low-field magnetic resonance imaging; Nailfold capillaroscopy; Spiroergometry; Realtime deformability cytometry |
| NCT05923840 | Mechanism of Chemoreflex and Baroreflex Alterations Causing Postural Tachycardia Syndrome in POTS Patients With Orthostatic Hyperpnea and Hypocapnia | UNKNOWN | nan | New York Medical College | Chemoreflex Testing; Baroreflex testing; Orthostatic stress testing |
| NCT05492292 | Long-term Effects of SARS-CoV-2 on the Central Nervous System and One-year Follow-up of "Long COVID-19" Patients | UNKNOWN | nan | Brugmann University Hospital | Perfusion brain scintigraphy imaging |
| NCT ID | Title | Status | Phase | Sponsor | Intervention |
|---|---|---|---|---|---|
| NCT05760092 | The Use of Photobiomodulation in the Treatment of Oral Complaints of Long COVID-19. A Randomized Controlled Trial. | COMPLETED | PHASE2 | University of Nove de Julho | Institutional standard treatment for xerostomia and Long Covid; Photobiomodulation Therapy; Placebo Photobiomodulation Therapy |
| NCT05445674 | Plasma Exchange Therapy for Post- COVID-19 Condition: A Pilot, Randomized Double-Blind Study | COMPLETED | PHASE2 | Fundación FLS de Lucha Contra el Sida, las Enfermedades Infecciosas y la Promoción de la Salud y la Ciencia | Plasma Exchange Procedure; Sham Plasma Exchange Procedure |
| NCT06441955 | Covid-19 Long Haul Syndrome: Undiagnosed Disorder Post Covid-19 Alternative Treatment Study. | RECRUITING | PHASE4 | Well- Konnect Healthcare Services and Research Firm | Ritonavir-Boosted Nirmatrelvir (Paxlovid); Physiological Evaluation; Moderna COVID-19 Vaccine; Biopsychological; Behavioral (e.g., Psychotherapy, Lifestyle Coun |
| NCT05901337 | Influence of Cupping Therapy on Immune System in Post Covid- 19 Patients | COMPLETED | nan | Cairo University | Cupping therapy with convential medical treatment; Convential medical treatment |
| NCT05476835 | Effect of Pulmonary Rehabilitation Program on Post Hospitalization Severe COVID- 19 Patients | COMPLETED | nan | Fayoum University Hospital | respiratory exercises - incentive spirometer - walking |
| NCT06967428 | Effectiveness of Metabolic Modulation in Treating Post-vaccination Syndrome: A Prospective Study | NOT_YET_RECRUITING | PHASE2 | Independent Medical Alliance | Combined metabolic modulator; Rice Protein Powder with Vitamin C |
| NCT06517706 | Brain Research and Integrative Neuroscience Network for COVID-19 (BRAINN) | RECRUITING | nan | University of Cyprus | Combination of tDCS (device) with cognitive training (behavioral); Categorization Program |
| NCT07409948 | Clinical Effectiveness and Implementation Outcomes of a Multicomponent Intervention for Aromatase Inhibitor-Associated Musculoskeletal Symptoms: A Hybrid Type 1 Randomized Controll | NOT_YET_RECRUITING | nan | Addis Ababa University | Multicomponent Care for Aromatase Inhibitor-Related Musculoskeletal Symptoms (AIMSS-CARE) |
| NCT04905888 | Hyperbaric Oxygen Therapy for Long COVID Patients With Pulmonary Sequela - Pilot Study | WITHDRAWN | PHASE2 | Peter Lindholm | Hyperbaric oxygen therapy |
| NCT04846010 | Treating Sequalae Caused by Post-acute Sequelae of SARS (Severe Acute Respiratory Syndrome)-CoV-2 Infection | UNKNOWN | PHASE1; PHASE2 | All Natural Medicine Clinic, LLC | PurWet; FurFat; PurApo; PurPhl; PurClo; PurInf; Smoliv |
| NCT06235177 | Psychoneuromentalism Disorder: A Condition Resulting From Behavioral Impairments, Neurodiversity, and Neurobehavioral Dysfunctions Related to the Mental and Emotional State of a Pe | NOT_YET_RECRUITING | EARLY_PHASE1 | The Essence of Integrative Health and Medicine Practice | Decompartmentalization Framework; Liquid Herbal TInctures; Mental Imagery; Clinical Yoga; Dietary Supplements; Applied Relaxation; Pain Relaxation Techniques; C |
| NCT06018649 | The Effectiveness and Safety of Using Lithuania's Natural Resources to Improve Stress-related Mental and Physical Health | UNKNOWN | nan | Klaipėda University | Balneotherapy plus complex; Combined nature resources treatment; Nature therapy procedure |
| NCT05397626 | Biofeedback and Hydrogen Water as Treatments for Chronic Fatigue Syndrome | UNKNOWN | PHASE1 | Stony Brook University | Heart Rhythm Biofeedback; Hydrogen Water; Combined treatment: Heart rhythm biofeedback plus hydrogen water |
| NCT ID | Title | Status | Phase | Sponsor | Intervention |
|---|---|---|---|---|---|
| NCT05760092 | The Use of Photobiomodulation in the Treatment of Oral Complaints of Long COVID-19. A Randomized Controlled Trial. | COMPLETED | PHASE2 | University of Nove de Julho | Institutional standard treatment for xerostomia and Long Covid; Photobiomodulation Therapy; Placebo Photobiomodulation Therapy |
| NCT05371522 | Neuro-inflammation and Post-infectious Fatigue in Individuals With and Without COVID-19 | UNKNOWN | PHASE2; PHASE3 | Amsterdam UMC, location VUmc | [18F]DPA-714 positron emission tomography (PET) scan |
| NCT ID | Title | Status | Phase | Sponsor | Intervention |
|---|---|---|---|---|---|
| NCT06441955 | Covid-19 Long Haul Syndrome: Undiagnosed Disorder Post Covid-19 Alternative Treatment Study. | RECRUITING | PHASE4 | Well- Konnect Healthcare Services and Research Firm | Ritonavir-Boosted Nirmatrelvir (Paxlovid); Physiological Evaluation; Moderna COVID-19 Vaccine; Biopsychological; Behavioral (e.g., Psychotherapy, Lifestyle Coun |
| NCT05817006 | Early Diagnosis, Prognosis and Prevention of Postcovid Syndrome in Children During the Pandemic of the New Coronavirus Infection COVID-19 | COMPLETED | nan | Samara State Medical University | Device |
This chart is data-driven directly from the CT.gov intervention_names field. Intervention names are split only on semicolons, cleaned, and mapped to canonical intervention labels using the external normalization dictionary where available. Comma splitting is intentionally avoided because commas can occur inside one intervention arm, for example in regimen descriptions. Each trial contributes at most once per normalized intervention concept. For readability and dashboard performance, the chart shows the top 100 of 1093 detected normalized intervention concepts.
| NCT ID | Title | Status | Phase | Sponsor | Intervention |
|---|---|---|---|---|---|
| NCT05299333 | Comparison of the Effectiveness of Pulmonary Telerehabilitation and Physical Activity Recommendations in Patients With Pulmonary Fibrosis Due to COVID-19 | COMPLETED | nan | Istanbul University - Cerrahpasa | Exercise |
| NCT04841759 | The Effects of a Multi-factorial Rehabilitation Program for Healthcare Workers Suffering From Post-COVID-19 Fatigue Syndrome | COMPLETED | nan | Medical University of Vienna | Exercise |
| NCT05435456 | Effect of Strengthening and Relaxation Exercises on Musculoskeletal Pain, Anxiety, and Sleep Quality on Post-covid Symptoms | COMPLETED | nan | Halic University | Exercise |
| NCT06795750 | The Effect of Neural Therapy on Heart Rate Recovery, Cardiac Parameters and Pain in Fibromyalgia: a Randomized Controlled Trial | COMPLETED | nan | Uşak University | neural therapy; Exercise |
| NCT04378634 | The Influence of Epigenetic Modifications and Post-Exertional Malaise in People With Myalgic Encephalomyelitis/Chronic Fatigue Syndrome | COMPLETED | nan | Vrije Universiteit Brussel | Exercise; Mental Stress Test |
| NCT04718506 | Rehabilitation for Post-COVID-19 Syndrome Through a Multicomponent, Educational and Supervised Exercise Intervention [RECOVE] | COMPLETED | nan | Universidad de Murcia | Exercise; Inspiratory muscle training; Controls |
| NCT06168006 | Effects of a Physical Training Program Using a Mobile App on the Functionality and Cardiovascular Function of Individuals With Post-covid-19 Syndrome: Randomized Clinical Trial | RECRUITING | nan | University of Nove de Julho | Exercise; Control |
| NCT05566483 | Physiological Underpinnings of Post-Acute Sequelae of SARS CoV-2 ("Long COVID") and Impact of Cardiopulmonary Rehabilitation on Quality-of-Life and Functional Capacity | RECRUITING | nan | University of Colorado, Denver | Exercise |
| NCT06165978 | Physical Activity Coaching in Patients with Post-COVID-19. a Randomised Clinical Trial. | SUSPENDED | nan | University of Alcala | Self-monitoring; Goal setting and review; Education; Feedback; Contact; Exercise; Report; Social support; Group activities; World Health Organization recommenda |
| NCT06065033 | Exercise as a Therapeutic for Those Diagnosed With Post-acute Sequelae of Covid-19 | WITHDRAWN | nan | University of Virginia | Exercise |
| NCT ID | Title | Status | Phase | Sponsor | Intervention |
|---|---|---|---|---|---|
| NCT05576662 | Selective Trial Of Paxlovid for PASC (STOP-PASC): Randomized Double-Blind Placebo-Controlled Pilot Trial of Paxlovid for the Treatment of PASC | COMPLETED | PHASE2 | Stanford University | Nirmatrelvir; Placebo; Ritonavir |
| NCT05965726 | RECOVER-VITAL: A Platform Protocol for Evaluation of Interventions for Viral Persistence, Viral Reactivation, and Immune Dysregulation in Post-Acute Sequelae of SARS-CoV-2 Infectio | COMPLETED | PHASE2 | Kanecia Obie Zimmerman | Paxlovid; Ritonavir; Nirmatrelvir-matching placebo |
| NCT05595369 | RECOVER-VITAL: A Platform Protocol for Evaluation of Interventions for Viral Persistence, Viral Reactivation, and Immune Dysregulation in Post-Acute Sequelae of SARS-CoV-2 Infectio | COMPLETED | PHASE2 | Kanecia Obie Zimmerman | Experimental: Paxlovid 25 day dosing; Experimental: Paxlovid 15 day dosing; Placebo Comparator: Control |
| NCT05668091 | An Interventional Decentralized Phase 2, Randomized, Double-Blind, 2-Arm Study to Investigate the Efficacy and Safety of Orally Administered Nirmatrelvir/Ritonavir Compared with Pl | COMPLETED | PHASE2 | Harlan M Krumholz | Nirmatrelvir; Ritonavir; Placebo |
| NCT05823896 | An Interventional, Double-Blinded, 2-Arm Study to Investigate the Efficacy of Orally Administered Nirmatrelvir/Ritonavir Compared with Placebo/Ritonavir in Non-hospitalized Adult P | COMPLETED | PHASE2 | Karolinska Institutet | Nirmatrelvir/ritonavir; Placebo/ritonavir |
| NCT05852873 | PAxlovid loNg cOvid-19 pRevention triAl With recruitMent In the Community in Norway | ACTIVE_NOT_RECRUITING | PHASE3 | Haukeland University Hospital | Nirmatrelvir/ritonavir; Placebo |
| NCT06441955 | Covid-19 Long Haul Syndrome: Undiagnosed Disorder Post Covid-19 Alternative Treatment Study. | RECRUITING | PHASE4 | Well- Konnect Healthcare Services and Research Firm | Ritonavir-Boosted Nirmatrelvir (Paxlovid); Physiological Evaluation; Moderna COVID-19 Vaccine; Biopsychological; Behavioral (e.g., Psychotherapy, Lifestyle Coun |
| NCT06792214 | Antiviral Strategies in the Prevention of Long-term Cardiovascular Outcomes Following COVID-19: The paxloviD/Remdesivir Effectiveness For the prEvention of loNg coviD (DEFEND) Clin | RECRUITING | PHASE4 | Mount Sinai Hospital, Canada | Nirmatrelvir/ritonavir; Remdesivir |
| NCT07597902 | SARS-CoV-2 and Herpesvirus Inhibition for Ending Long COVID Dysfunction (SHIELD) | NOT_YET_RECRUITING | PHASE2 | Icahn School of Medicine at Mount Sinai | Valacyclovir; Celecoxib; Paxlovid; Placebo |
| NCT ID | Title | Status | Phase | Sponsor | Intervention |
|---|---|---|---|---|---|
| NCT06476496 | Pain Relief With Integrative Medicine (PRIMe)?: Feasibility of Acupuncture for Long COVID | COMPLETED | nan | University of Washington | Acupuncture |
| NCT05212688 | A Randomised Phase II Study to Investigate the Effectiveness of ACUpuncture for the Relief of Long COVID Related Fatigue. | COMPLETED | PHASE2 | Royal Marsden NHS Foundation Trust | Acupuncture; Active Control |
| NCT06633666 | Acupuncture for Long COVID Neuropsychiatric Symptoms: a Pragmatic,Randomized Clinical Trial | RECRUITING | nan | Hong Kong Baptist University | Acupuncture |
| NCT07285707 | Acupuncture for Long COVID - A Pragmatic Pilot Study | RECRUITING | nan | Southern California University of Health Sciences | Acupuncture |
| NCT07357688 | The Effect of Acupuncture Therapy on Cognitive Function in Post-COVID-19 Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Study With Multimodal Magnetic Resonance Imaging | NOT_YET_RECRUITING | nan | Xi Wu | Acupuncture; Sham acupuncture |
| NCT07355751 | The Effect of Acupuncture Treatment on Cognitive Functions and Brain Networks for Long COVID: a Multimodal Magnetic Resonance Imaging Study | NOT_YET_RECRUITING | nan | Tingting Luo | Acupuncture; Sham acupuncture |
| NCT06144320 | The Objective of Our Study is to Evaluate the Medium and Long-term Clinical Efficacy of Acupuncture in Patients With Post Covid Related Mild Cognitive Impairment (MCI). | UNKNOWN | nan | China Medical University Hospital | Acupuncture |
| NCT05890508 | Electro-acupuncture for Long Covid Neuropsychiatric Symptoms: a Prospective, Randomized Sham-controlled, Double-blinded Clinical Trial | UNKNOWN | nan | Hong Kong Baptist University | Acupuncture; Sham-acupuncture |
| NCT05749757 | The Efficacy and Safety of Acupuncture for Post COVID-19 Fatigue: a Randomized Controlled Trial | UNKNOWN | nan | Guang'anmen Hospital of China Academy of Chinese Medical Sciences | Acupuncture; Sham Acupuncture |
| NCT ID | Title | Status | Phase | Sponsor | Intervention |
|---|---|---|---|---|---|
| NCT05196529 | Inspiratory Muscle Training in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) and COVID-19 Survivors | COMPLETED | nan | York University | Inspiratory muscle training |
| NCT04718506 | Rehabilitation for Post-COVID-19 Syndrome Through a Multicomponent, Educational and Supervised Exercise Intervention [RECOVE] | COMPLETED | nan | Universidad de Murcia | Exercise; Inspiratory muscle training; Controls |
| NCT05279430 | Effects of Inspiratory Muscle Training on Maximal Functional Capacity in Patients With Chronic COVID After Hospital Discharge | COMPLETED | nan | Fundación para la Investigación del Hospital Clínico de Valencia | Inspiratory muscle training |
| NCT05077241 | Efficacy of Home Inspiratory Muscle Training in Post-covid-19 Patients: a Randomized Clinical Trial | UNKNOWN | nan | Universidade Federal do Rio Grande do Norte | Inspiratory muscle training |
| NCT ID | Title | Status | Phase | Sponsor | Intervention |
|---|---|---|---|---|---|
| NCT05676047 | Symptom-Targeted Rehabilitation for Cognitive Complaints in Long COVID (STAR-C3) | COMPLETED | nan | McMaster University | Cognitive Rehabilitation; Education |
| NCT06404047 | RECOVER-ENERGIZE: A Platform Protocol for Evaluation of Interventions for Exercise Intolerance in Post-Acute Sequelae of SARS-CoV-2 Infection (PASC) | COMPLETED | nan | Duke University | Personalized Cardiopulmonary Rehabilitation; Structured Pacing; Education; Usual Care |
| NCT06404060 | RECOVER-ENERGIZE: A Platform Protocol for Evaluation of Interventions for Exercise Intolerance in Post-Acute Sequelae of SARS-CoV-2 Infection (PASC) | ACTIVE_NOT_RECRUITING | nan | Duke University | Personalized Cardiopulmonary Rehabilitation; Education |
| NCT06165978 | Physical Activity Coaching in Patients with Post-COVID-19. a Randomised Clinical Trial. | SUSPENDED | nan | University of Alcala | Self-monitoring; Goal setting and review; Education; Feedback; Contact; Exercise; Report; Social support; Group activities; World Health Organization recommenda |
| NCT ID | Title | Status | Phase | Sponsor | Intervention |
|---|---|---|---|---|---|
| NCT05212688 | A Randomised Phase II Study to Investigate the Effectiveness of ACUpuncture for the Relief of Long COVID Related Fatigue. | COMPLETED | PHASE2 | Royal Marsden NHS Foundation Trust | Acupuncture; Active Control |
| NCT04301609 | Randomized, Comparative, Double-blind, and Placebo-controlled Clinical Trial to Assess the Improvement of Fatigue, Sleep, Anxiety / Depression, Neurovegetatives Alterations and Qua | COMPLETED | nan | Vitae Health Innovation | Active; Placebo |
| NCT06063031 | Investigation of a Specialized Nutritional Intervention and Rehabilitation Treatment in Patients With Post-COVID Condition to Improve Their Quality of Life: ARACOV-02 | UNKNOWN | nan | Instituto de Investigación Sanitaria Aragón | Active; Placebo |
| NCT ID | Title | Status | Phase | Sponsor | Intervention |
|---|---|---|---|---|---|
| NCT05638633 | Prednisolone and Vitamin B1, B6, and B12 in Patients With Post-COVID-19-Syndrome (PC19S) - a Randomized Controlled Trial in Primary Care | COMPLETED | PHASE3 | Wuerzburg University Hospital | Prednisolone 20 mg/ 5 mg; Vitamin B compound (100mg B1, 50 mg B6, 500 µg B12); Placebo for Vitamin B compound; Placebo for Prednisolon |
| NCT05619653 | Randomised Placebo Controlled Clinical Trial of Efficacy of MYOcardial Protection in Patients With Postacute inFLAMmatory Cardiac involvEment Due to COVID-19 | ACTIVE_NOT_RECRUITING | PHASE3 | Valentina Puentmann | Prednisolone; Losartan |
| NCT07380152 | Corticosteroid Treatment for Post-COVID-19 Persistent Interstitial Lung Disease | COMPLETED | PHASE1 | University of Sao Paulo | Prednisolone |
| NCT ID | Title | Status | Phase | Sponsor | Intervention |
|---|---|---|---|---|---|
| NCT04510194 | COVID-OUT: Early Outpatient Treatment for SARS-CoV-2 Infection (COVID-19) | COMPLETED | PHASE3 | University of Minnesota | Metformin; Placebo; Fluvoxamine; Ivermectin |
| NCT07280572 | RECLAIM: an Adaptive Platform Trial for the Evaluation of Treatments for Post-Acute Sequelae of SARS-CoV-2 Infection (PASC) | ENROLLING_BY_INVITATION | PHASE3 | Janneke van de Wijgert | Metformin; colchicine |
| NCT06147050 | Pilot Study of an Adaptive, Double-blind, Randomized, Placebo-controlled Study to Evaluate the Effect of Metformin in Reducing Fatigue in Long COVID Adolescent Patients With Chroni | UNKNOWN | PHASE3 | Purpose Life Sciences | Metformin; Placebo |
| NCT ID | Title | Status | Phase | Sponsor | Intervention |
|---|---|---|---|---|---|
| NCT04510194 | COVID-OUT: Early Outpatient Treatment for SARS-CoV-2 Infection (COVID-19) | COMPLETED | PHASE3 | University of Minnesota | Metformin; Placebo; Fluvoxamine; Ivermectin |
| NCT05874037 | Fluvoxamine as a Treatment for Long COVID-19: A Randomized Placebo Controlled Trial | COMPLETED | PHASE2; PHASE3 | Washington University School of Medicine | Fluvoxamine |
| NCT07359482 | sElective Serotonin reuPtake inhibitoRs In posT-covid: ESPRIT | NOT_YET_RECRUITING | PHASE3 | Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) | Fluvoxamine; Placebo |
| NCT ID | Title | Status | Phase | Sponsor | Intervention |
|---|---|---|---|---|---|
| NCT05092516 | Home-based Transcranial Direct Current Stimulation (tDCS) for Treatment of Cognitive Post-acute Sequelae of COVID-19 (PASC) | ACTIVE_NOT_RECRUITING | nan | Massachusetts General Hospital | Active tDCS; Sham tDCS |
| NCT05252481 | Modulation of Post-COVID-19 Fatigue Using Transcranial Direct Current Stimulation. Transcranial Direct Stimulation for Persistent Fatigue Treatment Post-COVID-19 | COMPLETED | nan | Hospital San Carlos, Madrid | Active tDCS; Sham tDCS |
| NCT05589272 | TDCS-potentiated Generalization of Cognitive Training in the Rehabilitation of Long COVID Symptoms | WITHDRAWN | nan | University of Minnesota | Active tDCS; Sham tDCS |
| NCT ID | Title | Status | Phase | Sponsor | Intervention |
|---|---|---|---|---|---|
| NCT05092516 | Home-based Transcranial Direct Current Stimulation (tDCS) for Treatment of Cognitive Post-acute Sequelae of COVID-19 (PASC) | ACTIVE_NOT_RECRUITING | nan | Massachusetts General Hospital | Active tDCS; Sham tDCS |
| NCT05252481 | Modulation of Post-COVID-19 Fatigue Using Transcranial Direct Current Stimulation. Transcranial Direct Stimulation for Persistent Fatigue Treatment Post-COVID-19 | COMPLETED | nan | Hospital San Carlos, Madrid | Active tDCS; Sham tDCS |
| NCT05589272 | TDCS-potentiated Generalization of Cognitive Training in the Rehabilitation of Long COVID Symptoms | WITHDRAWN | nan | University of Minnesota | Active tDCS; Sham tDCS |
| NCT ID | Title | Status | Phase | Sponsor | Intervention |
|---|---|---|---|---|---|
| NCT06305780 | RECOVER-AUTONOMIC: A Platform Protocol for Evaluation of Interventions for Autonomic Dysfunction in Post-Acute Sequelae of SARS-CoV-2 Infection (PASC) | COMPLETED | PHASE2 | Kanecia Obie Zimmerman | IVIG + Coordinated Care; IVIG Placebo + Coordinated Care; Ivabradine + Coordinated Care; Ivabradine Placebo + Coordinated Care; IVIG + Usual Care; IVIG Placebo |
| NCT06305806 | RECOVER-AUTONOMIC (Ivabradine): Randomized Trial of the Effect of Ivabradine Versus Placebo on Long COVID Symptoms | COMPLETED | PHASE2 | Kanecia Obie Zimmerman | Ivabradine; Ivabradine Placebo; Coordinated Care; Usual Care |
| NCT05481177 | Comparative Cohort Study of Post-acute COVID-19 Infection With a Nested, Randomized Controlled Trial of Ivabradine for Those With Postural Orthostatic Tachycardia Syndrome. | UNKNOWN | PHASE4 | Uniformed Services University of the Health Sciences | Ivabradine |
| NCT ID | Title | Status | Phase | Sponsor | Intervention |
|---|---|---|---|---|---|
| NCT06253806 | Stellate Ganglion Block for the Treatment of COVID-19-Induced Parosmia: Double-Blinded, Placebo-Controlled Randomized Clinical Trial | COMPLETED | PHASE2 | Washington University School of Medicine | Stellate Ganglion Block; Placebo Sham Injection |
| NCT05445921 | Stellate Ganglion Block for the Treatment of COVID-19-Induced Olfactory Dysfunction: A Prospective Pilot Study | COMPLETED | PHASE1; PHASE2 | Washington University School of Medicine | Stellate Ganglion Block |
| NCT06055270 | Stellate Ganglion Block With Lidocaine for the Treatment of COVID-19-Induced Parosmia: Double-Blinded, Placebo-Controlled Randomized Clinical Trial | UNKNOWN | PHASE3 | London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's | Stellate Ganglion Block; Placebo |
| NCT ID | Title | Status | Phase | Sponsor | Intervention |
|---|---|---|---|---|---|
| NCT06055244 | Amantadine Therapy for Cognitive Impairment Related to Post-COVID Condition | COMPLETED | PHASE2 | Ohio State University | Amantadine |
| NCT06234462 | Feasibility Study of Amantadine for Cognitive Dysfunction in Patients With Long-Covid: A Pilot Randomized Control Trial | WITHDRAWN | PHASE2 | University of Texas Southwestern Medical Center | Amantadine; Physical, Occupational, Speech Therapy; Provider Counseling; Medications for symptoms management |
| NCT05667077 | The Effect of Amantadine on Post-COVD-19 Fatigue: a Clinical Trial | UNKNOWN | PHASE2 | Shahid Beheshti University of Medical Sciences | Amantadine |
| NCT ID | Title | Status | Phase | Sponsor | Intervention |
|---|---|---|---|---|---|
| NCT05430152 | A Double Blind Randomized Trial of Low-dose Naltrexone for Post-COVID Fatigue Syndrome | COMPLETED | PHASE2 | Luis Nacul | Low-Dose Naltrexone; Placebo |
| NCT06366724 | LIFT: Life Improvement Trial | RECRUITING | PHASE2 | Brigham and Women's Hospital | Pyridostigmine; Low-Dose Naltrexone; Placebo |
| NCT07285473 | Low-dose Naltrexone (LDN) for the Treatment of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS): Dose-Finding | NOT_YET_RECRUITING | PHASE2 | University of Alabama at Birmingham | Low-Dose Naltrexone, 1.5mg; Low-Dose Naltrexone, 3.0mg; Low-Dose Naltrexone, 4.5mg; Low-Dose Naltrexone, 6.0mg |
| NCT ID | Title | Status | Phase | Sponsor | Intervention |
|---|---|---|---|---|---|
| NCT05710770 | Double-blinded, Randomized, Sham-controlled Trial of Immunoadsorption (IA) in Patients With Chronic Fatigue Syndrome (CFS) Including Patients With Post-acute COVID-19 CFS (PACS-CFS | COMPLETED | nan | Charite University, Berlin, Germany | Immunoadsorption |
| NCT05841498 | A Single-blinded Sham-controlled Crossover Trial to Evaluate the Effect of Immunoadsorption on Post-Corona Virus Disease (COVID)-Syndrome | COMPLETED | nan | University Medical Center Mainz | Immunoadsorption; Sham-apheresis |
| NCT07316127 | A Placebo-Controlled, Double-Blind, Randomized Trial Phase I-II With Immunoadsorption in Autoimmune Long COVID | RECRUITING | PHASE2 | Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) | Immunoadsorption; Sham Comparator |
| NCT ID | Title | Status | Phase | Sponsor | Intervention |
|---|---|---|---|---|---|
| NCT05798221 | Complementary Self-help Strategies for Patients With Post-COVID-19 Syndrome: A Randomized Controlled Trial | COMPLETED | nan | Universität Duisburg-Essen | Complementary self-help strategies in addition to treatment as usual; Treatment as usual |
| NCT05793736 | A Feasibility Study of an HVR Protocol Biofeedback Training to Manage Long Covid Syndrome Symptoms | COMPLETED | nan | University of Cagliari | Biofeedback training; Treatment as usual |
| NCT05212467 | Amygdala and Insula Retraining (AIR) Program and HUS Internet Therapy Compared to Treatment as Usual in Bodily Stress Syndrome, Fibromyalgia, Post Covid-19, and Chronic Fatigue Syn | UNKNOWN | nan | Helsinki University Central Hospital | AIR-program; HUS Internet therapy; Treatment as usual |
| NCT ID | Title | Status | Phase | Sponsor | Intervention |
|---|---|---|---|---|---|
| NCT06952413 | An Exploratory, Placebo-controlled, Double-blind, Phase II Study of the Efficacy and Safety for Rituximab (Genetical Recombination) in Myalgia Encephalomyelitis/Chronic Fatigue Syn | RECRUITING | PHASE2 | National Center of Neurology and Psychiatry, Japan | Rituximab(Genetical Recombination); Placebo |
| NCT05682196 | Open-label, Randomized Controlled Trial to Assess Efficacy and Safety of Rituximab in Patients With Acute Rheumatic Fever in Africa | SUSPENDED | PHASE2 | African Academy of Methodology and Statistics | Rituximab added to standard of care treatment; standard of care treatment alone |
| NCT04507477 | Ex-vivo Delivery of Rituximab to Prevent Post-transplant Lymphoproliferative Disease in Epstein-Barr Virus Mismatch Lung Transplant Recipients: A Pilot Trial | UNKNOWN | PHASE1; PHASE2 | University Health Network, Toronto | Rituximab |
| NCT ID | Title | Status | Phase | Sponsor | Intervention |
|---|---|---|---|---|---|
| NCT06305780 | RECOVER-AUTONOMIC: A Platform Protocol for Evaluation of Interventions for Autonomic Dysfunction in Post-Acute Sequelae of SARS-CoV-2 Infection (PASC) | COMPLETED | PHASE2 | Kanecia Obie Zimmerman | IVIG + Coordinated Care; IVIG Placebo + Coordinated Care; Ivabradine + Coordinated Care; Ivabradine Placebo + Coordinated Care; IVIG + Usual Care; IVIG Placebo |
| NCT06305793 | RECOVER-AUTONOMIC (IVIG): Randomized Trial of the Effect of IVIG Versus Placebo on Long COVID Symptoms | ACTIVE_NOT_RECRUITING | PHASE2 | Kanecia Obie Zimmerman | IVIG (intravenous immunoglobulin); IVIG Placebo; Coordinated Care; Usual Care |
| NCT05350774 | Immunotherapy for Neurological Post-Acute Sequelae of SARS-CoV-2 (IN-PASC) | ENROLLING_BY_INVITATION | PHASE2 | National Institute of Neurological Disorders and Stroke (NINDS) | IV normal saline; IV immunoglobulin |
| NCT ID | Title | Status | Phase | Sponsor | Intervention |
|---|---|---|---|---|---|
| NCT04904536 | An International, Investigator Initiated and Conducted, Pragmatic Clinical Trial to Determine Whether 40mg Atorvastatin Daily Can Improve Neurocognitive Function in Adults With Lon | ACTIVE_NOT_RECRUITING | PHASE3 | The George Institute | Atorvastatin; Standard Care |
| NCT06974084 | A Multi-Center Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy of Maraviroc and Atorvastatin for the Treatment of Subjects With Long COVID/Post-Acute Se | NOT_YET_RECRUITING | PHASE2; PHASE3 | HealthBio, Inc. | Maraviroc (MVC); Atorvastatin, 10mg, 20mg, 40mg; Placebo, Maraviroc; Placebo, Atorvastatin |
| NCT04801940 | HElping Alleviate the Longer-term Consequences of COVID-19 (HEAL-COVID): a National Platform Trial | UNKNOWN | PHASE3 | Cambridge University Hospitals NHS Foundation Trust | Apixaban; Atorvastatin |
| NCT ID | Title | Status | Phase | Sponsor | Intervention |
|---|---|---|---|---|---|
| NCT05965752 | RECOVER-NEURO: A Platform Protocol for Evaluation of Interventions for Cognitive Dysfunction in Post-Acute Sequelae of SARS-CoV-2 Infection (PASC) | COMPLETED | nan | Duke University | BrainHQ/Active Comparator Activity; BrainHQ; PASC CoRE; tDCS-active; tDCS-sham |
| NCT05965739 | RECOVER-NEURO: A Platform Protocol for Evaluation of Interventions for Cognitive Dysfunction in Post-Acute Sequelae of SARS-CoV-2 Infection (PASC) | COMPLETED | nan | Duke University | BrainHQ/Active Comparator Activity; BrainHQ; PASC CoRE; tDCS-active; tDCS-sham |
| NCT ID | Title | Status | Phase | Sponsor | Intervention |
|---|---|---|---|---|---|
| NCT05911906 | An Open-label, Clinical Feasibility Study of the Efficacy of Remdesivir for Long-COVID. | COMPLETED | PHASE4 | University of Derby | Remdesivir |
| NCT06792214 | Antiviral Strategies in the Prevention of Long-term Cardiovascular Outcomes Following COVID-19: The paxloviD/Remdesivir Effectiveness For the prEvention of loNg coviD (DEFEND) Clin | RECRUITING | PHASE4 | Mount Sinai Hospital, Canada | Nirmatrelvir/ritonavir; Remdesivir |
| NCT ID | Title | Status | Phase | Sponsor | Intervention |
|---|---|---|---|---|---|
| NCT05795816 | The Effectiveness of Testofen on Energy, Fatigue, Mental Acuity, and Other Quality of Life Symptoms Post COVID-19 Infection | COMPLETED | PHASE3 | RDC Clinical Pty Ltd | Testofen; Microcrystalline cellulose |
| NCT05363514 | A Pilot Study of Low Dose Naltrexone Use in Patients With Postural Orthostatic Tachycardia Syndrome | NOT_YET_RECRUITING | PHASE4 | University of Calgary | Low Dose Naltrexone; Microcrystalline cellulose |
| NCT ID | Title | Status | Phase | Sponsor | Intervention |
|---|---|---|---|---|---|
| NCT04313972 | IC PaIN Trial: Interstitial Cystitis Pain Improvement With Naltrexone, the Effect of Low Dose Naltrexone on Symptoms and Pain of Patients With Interstitial Cystitis/Painful Bladder | TERMINATED | PHASE4 | Endeavor Health | low-dose naltrexone; Placebo oral tablet |
| NCT04140721 | Autonomic Determinants of Postural Tachycardia Syndrome (Chronic Pilot Study 2) | ACTIVE_NOT_RECRUITING | EARLY_PHASE1 | Vanderbilt University Medical Center | Placebo oral tablet; Moxonidine Pill |
| NCT ID | Title | Status | Phase | Sponsor | Intervention |
|---|---|---|---|---|---|
| NCT05205460 | Effectiveness of a 12-week Telerehabilitation Training in People With Long COVID: A Randomized Controlled Trial | COMPLETED | nan | Tri-Service General Hospital | Home-based telerehabilitation; Education and self-exercise |
| NCT07553897 | Effectiveness of a Tele-Exercise Training Program on Long COVID Symptoms and Quality of Life in Patients With Long COVID | COMPLETED | nan | Tri-Service General Hospital | Telehealth exercise training program; Education and self-exercise |
| NCT ID | Title | Status | Phase | Sponsor | Intervention |
|---|---|---|---|---|---|
| NCT05965752 | RECOVER-NEURO: A Platform Protocol for Evaluation of Interventions for Cognitive Dysfunction in Post-Acute Sequelae of SARS-CoV-2 Infection (PASC) | COMPLETED | nan | Duke University | BrainHQ/Active Comparator Activity; BrainHQ; PASC CoRE; tDCS-active; tDCS-sham |
| NCT05965739 | RECOVER-NEURO: A Platform Protocol for Evaluation of Interventions for Cognitive Dysfunction in Post-Acute Sequelae of SARS-CoV-2 Infection (PASC) | COMPLETED | nan | Duke University | BrainHQ/Active Comparator Activity; BrainHQ; PASC CoRE; tDCS-active; tDCS-sham |
| NCT ID | Title | Status | Phase | Sponsor | Intervention |
|---|---|---|---|---|---|
| NCT05080244 | Evaluation of the Efficacy of Probiotics Taken During the Acute Phase of COVID-19 to Reduce the Occurrence of Long COVID | COMPLETED | nan | Centre de recherche du Centre hospitalier universitaire de Sherbrooke | Probiotics; Placebo |
| NCT03773003 | Pathophysiology of Cancer Related Fatigue (CRF) and Chronic Fatigue (CFS/ME) by Lipidomics, Metabolomics, Microbiome and Exome Analysis and Investigation of Clinical Improvement Un | RECRUITING | nan | Universität des Saarlandes | Probiotics; Placebo |
| NCT ID | Title | Status | Phase | Sponsor | Intervention |
|---|---|---|---|---|---|
| NCT05965752 | RECOVER-NEURO: A Platform Protocol for Evaluation of Interventions for Cognitive Dysfunction in Post-Acute Sequelae of SARS-CoV-2 Infection (PASC) | COMPLETED | nan | Duke University | BrainHQ/Active Comparator Activity; BrainHQ; PASC CoRE; tDCS-active; tDCS-sham |
| NCT05965739 | RECOVER-NEURO: A Platform Protocol for Evaluation of Interventions for Cognitive Dysfunction in Post-Acute Sequelae of SARS-CoV-2 Infection (PASC) | COMPLETED | nan | Duke University | BrainHQ/Active Comparator Activity; BrainHQ; PASC CoRE; tDCS-active; tDCS-sham |
| NCT ID | Title | Status | Phase | Sponsor | Intervention |
|---|---|---|---|---|---|
| NCT05965752 | RECOVER-NEURO: A Platform Protocol for Evaluation of Interventions for Cognitive Dysfunction in Post-Acute Sequelae of SARS-CoV-2 Infection (PASC) | COMPLETED | nan | Duke University | BrainHQ/Active Comparator Activity; BrainHQ; PASC CoRE; tDCS-active; tDCS-sham |
| NCT05965739 | RECOVER-NEURO: A Platform Protocol for Evaluation of Interventions for Cognitive Dysfunction in Post-Acute Sequelae of SARS-CoV-2 Infection (PASC) | COMPLETED | nan | Duke University | BrainHQ/Active Comparator Activity; BrainHQ; PASC CoRE; tDCS-active; tDCS-sham |
| NCT ID | Title | Status | Phase | Sponsor | Intervention |
|---|---|---|---|---|---|
| NCT05965752 | RECOVER-NEURO: A Platform Protocol for Evaluation of Interventions for Cognitive Dysfunction in Post-Acute Sequelae of SARS-CoV-2 Infection (PASC) | COMPLETED | nan | Duke University | BrainHQ/Active Comparator Activity; BrainHQ; PASC CoRE; tDCS-active; tDCS-sham |
| NCT05965739 | RECOVER-NEURO: A Platform Protocol for Evaluation of Interventions for Cognitive Dysfunction in Post-Acute Sequelae of SARS-CoV-2 Infection (PASC) | COMPLETED | nan | Duke University | BrainHQ/Active Comparator Activity; BrainHQ; PASC CoRE; tDCS-active; tDCS-sham |
| NCT ID | Title | Status | Phase | Sponsor | Intervention |
|---|---|---|---|---|---|
| NCT05592418 | A Randomized, Double Blind, Placebo Controlled Study to Evaluate the Efficacy and Safety of Ampligen® in Patients With Post-COVID Conditions | COMPLETED | PHASE2 | AIM ImmunoTech Inc. | Rintatolimod; Placebo / Normal Saline |
| NCT06204432 | Efficacy of Adjunctive Sodium Citrate in Smell Retraining for People With Post-Acute Sequelae COVID-19 Olfactory Dysfunction | ACTIVE_NOT_RECRUITING | PHASE2 | University of North Carolina, Chapel Hill | Sodium Citrate; Normal Saline; Olfactory Training Kit - "The Olfactory Kit, by AdvancedRx" |
| NCT ID | Title | Status | Phase | Sponsor | Intervention |
|---|---|---|---|---|---|
| NCT05618587 | Effect of Low-dose Lithium Therapy on Long COVID Symptoms: a Randomized Controlled Trial. | COMPLETED | PHASE2 | State University of New York at Buffalo | Lithium; Placebo |
| NCT06108297 | Effect of Low-dose Lithium Therapy on Long COVID Symptoms: an Open-label, Dose-finding Study. | COMPLETED | PHASE1 | State University of New York at Buffalo | Lithium |
| NCT ID | Title | Status | Phase | Sponsor | Intervention |
|---|---|---|---|---|---|
| NCT06404112 | RECOVER-SLEEP: A Platform Protocol for Evaluation of Interventions for Sleep Disturbances in Post-Acute Sequelae of SARS-CoV-2 Infection (PASC) | COMPLETED | PHASE2 | Duke University | Melatonin; Melantonin Placebo; Tailored lighting (TL) Active; Tailored lighting (TL) Placebo |
| NCT06404086 | RECOVER-SLEEP: A Platform Protocol for Evaluation of Interventions for Sleep Disturbances in Post-Acute Sequelae of SARS-CoV-2 Infection (PASC) | COMPLETED | PHASE2 | Duke University | Modafinil; Modafinil Placebo; Solriamfetol; Solriamfetol Placebo; Melatonin; Melantonin Placebo; Tailored lighting (TL) Active; Tailored lighting (TL) Placebo |
| NCT ID | Title | Status | Phase | Sponsor | Intervention |
|---|---|---|---|---|---|
| NCT06133075 | Using Mirabegron to Increase Blood Pressure in Patients With Postural Orthostatic Tachycardia Syndrome | COMPLETED | PHASE2 | Cedars-Sinai Medical Center | Mirabegron 50 MG; Mirabegron 25 MG |
| NCT07585513 | A Randomized Placebo-Controlled Clinical Trial Evaluating Mirabegron's Effectiveness in Alleviating POTS Symptoms | NOT_YET_RECRUITING | PHASE2 | Cedars-Sinai Medical Center | Mirabegron; Placebo |
| NCT ID | Title | Status | Phase | Sponsor | Intervention |
|---|---|---|---|---|---|
| NCT05682560 | A Randomized Controlled Phase IIa, Two-arm Study to Assess the Safety and Efficacy of Human Umbilical Cord Blood (RegeneCyte) Infusion in Patients with Post-COVID Syndrome | COMPLETED | PHASE2 | StemCyte, Inc. | REGENECYTE; Placebo |
| NCT07184385 | A Multicenter, Double-blind, Randomized, Placebo-controlled, Two-arm Phase III Study to Assess the Efficacy of Human Umbilical Cord Blood (REGENECYTE) Infusion in Reducing Fatigue | NOT_YET_RECRUITING | PHASE3 | StemCyte, Inc. | REGENECYTE; Placebo |
| NCT ID | Title | Status | Phase | Sponsor | Intervention |
|---|---|---|---|---|---|
| NCT06404112 | RECOVER-SLEEP: A Platform Protocol for Evaluation of Interventions for Sleep Disturbances in Post-Acute Sequelae of SARS-CoV-2 Infection (PASC) | COMPLETED | PHASE2 | Duke University | Melatonin; Melantonin Placebo; Tailored lighting (TL) Active; Tailored lighting (TL) Placebo |
| NCT06404086 | RECOVER-SLEEP: A Platform Protocol for Evaluation of Interventions for Sleep Disturbances in Post-Acute Sequelae of SARS-CoV-2 Infection (PASC) | COMPLETED | PHASE2 | Duke University | Modafinil; Modafinil Placebo; Solriamfetol; Solriamfetol Placebo; Melatonin; Melantonin Placebo; Tailored lighting (TL) Active; Tailored lighting (TL) Placebo |
| NCT ID | Title | Status | Phase | Sponsor | Intervention |
|---|---|---|---|---|---|
| NCT06952127 | Pilot Study Evaluating the Feasibility and Appropriateness of a Telerehabilitation Exercise Program in People With Post-COVID-19 Sequelae: a Single-center Randomized Trial. | COMPLETED | nan | Centre intégré universitaire de santé et de services sociaux de la Mauricie-et-du-Centre-du-Québec | Rehabilitation program |
| NCT05848518 | Effect of Different Types of Supervised Exercise Programs on Cardiorespiratory and Muscular Fitness, Pain, Fatigue, Mental Health and Inflammatory and Oxidative Stress Biomarkers i | COMPLETED | nan | Campus docent Sant Joan de Déu-Universitat de Barcelona | Rehabilitation program |
| NCT ID | Title | Status | Phase | Sponsor | Intervention |
|---|---|---|---|---|---|
| NCT05024474 | Effects of Inspiratory Muscle Training After Covid-19 | COMPLETED | nan | Karolinska Institutet | Inspiratory muscle training (IMT); Physical exercise |
| NCT07397910 | Clinical Trial to Analyze the Effectiveness of a Natural Compound on Chronic Immune-mediated Inflammatory Status in Subjects Who Have Had SARS-CoV-2 Infection. | NOT_YET_RECRUITING | nan | Universidad Católica San Antonio de Murcia | Experimental Product; Control placebo; Physical exercise; No Physical Exercise |
| NCT ID | Title | Status | Phase | Sponsor | Intervention |
|---|---|---|---|---|---|
| NCT06840873 | Effectiveness of a 8-week Tele-Rehabilitative Exercise Training Program on Fatigue, Symptom Severity, and Quality of Life in Nurses With Long COVID: A Randomized Controlled Trial | COMPLETED | nan | Shang-Lin Chiang | wearable device; Healthy consulation |
| NCT05922865 | Tri-service General Hospital, National Defence Medical Center, Taipei, Taiwan | COMPLETED | nan | Shang-Lin Chiang | KNEESUP smart knee assistive device + KNEESUP care APP; Healthy consulation |
| NCT ID | Title | Status | Phase | Sponsor | Intervention |
|---|---|---|---|---|---|
| NCT05445674 | Plasma Exchange Therapy for Post- COVID-19 Condition: A Pilot, Randomized Double-Blind Study | COMPLETED | PHASE2 | Fundación FLS de Lucha Contra el Sida, las Enfermedades Infecciosas y la Promoción de la Salud y la Ciencia | Plasma Exchange Procedure; Sham Plasma Exchange Procedure |
| NCT05543590 | Effect of Plasmapheresis on Clinical Improvement and Biological Parameters of Patients With Long-haul COVID: PLEXCOVIL Study, a Randomized Controlled Study. | WITHDRAWN | nan | Hôpital Européen Marseille | Plasmapheresis; Blood collection; Stool samples; PET scan; Cycle ergometer stress test; Questionnaires at baseline; Medical consultations |
| NCT ID | Title | Status | Phase | Sponsor | Intervention |
|---|---|---|---|---|---|
| NCT06305806 | RECOVER-AUTONOMIC (Ivabradine): Randomized Trial of the Effect of Ivabradine Versus Placebo on Long COVID Symptoms | COMPLETED | PHASE2 | Kanecia Obie Zimmerman | Ivabradine; Ivabradine Placebo; Coordinated Care; Usual Care |
| NCT06305793 | RECOVER-AUTONOMIC (IVIG): Randomized Trial of the Effect of IVIG Versus Placebo on Long COVID Symptoms | ACTIVE_NOT_RECRUITING | PHASE2 | Kanecia Obie Zimmerman | IVIG (intravenous immunoglobulin); IVIG Placebo; Coordinated Care; Usual Care |
| NCT ID | Title | Status | Phase | Sponsor | Intervention |
|---|---|---|---|---|---|
| NCT06404073 | RECOVER-ENERGIZE: A Platform Protocol for Evaluation of Interventions for Exercise Intolerance in Post-Acute Sequelae of SARS-CoV-2 Infection (PASC) | COMPLETED | nan | Duke University | Structured Pacing; Usual Care |
| NCT06404047 | RECOVER-ENERGIZE: A Platform Protocol for Evaluation of Interventions for Exercise Intolerance in Post-Acute Sequelae of SARS-CoV-2 Infection (PASC) | COMPLETED | nan | Duke University | Personalized Cardiopulmonary Rehabilitation; Structured Pacing; Education; Usual Care |
| NCT ID | Title | Status | Phase | Sponsor | Intervention |
|---|---|---|---|---|---|
| NCT06404099 | RECOVER-SLEEP: A Platform Protocol for Evaluation of Interventions for Sleep Disturbances in Post-Acute Sequelae of SARS-CoV-2 Infection (PASC) | COMPLETED | PHASE2 | Duke University | Modafinil; Modafinil Placebo; Solriamfetol; Solriamfetol Placebo |
| NCT06404086 | RECOVER-SLEEP: A Platform Protocol for Evaluation of Interventions for Sleep Disturbances in Post-Acute Sequelae of SARS-CoV-2 Infection (PASC) | COMPLETED | PHASE2 | Duke University | Modafinil; Modafinil Placebo; Solriamfetol; Solriamfetol Placebo; Melatonin; Melantonin Placebo; Tailored lighting (TL) Active; Tailored lighting (TL) Placebo |
| NCT ID | Title | Status | Phase | Sponsor | Intervention |
|---|---|---|---|---|---|
| NCT06404099 | RECOVER-SLEEP: A Platform Protocol for Evaluation of Interventions for Sleep Disturbances in Post-Acute Sequelae of SARS-CoV-2 Infection (PASC) | COMPLETED | PHASE2 | Duke University | Modafinil; Modafinil Placebo; Solriamfetol; Solriamfetol Placebo |
| NCT06404086 | RECOVER-SLEEP: A Platform Protocol for Evaluation of Interventions for Sleep Disturbances in Post-Acute Sequelae of SARS-CoV-2 Infection (PASC) | COMPLETED | PHASE2 | Duke University | Modafinil; Modafinil Placebo; Solriamfetol; Solriamfetol Placebo; Melatonin; Melantonin Placebo; Tailored lighting (TL) Active; Tailored lighting (TL) Placebo |
| NCT ID | Title | Status | Phase | Sponsor | Intervention |
|---|---|---|---|---|---|
| NCT05866224 | Effects of a Telerehabilitation Program and Detraining on Cardiorespiratory Fitness in Patients With Post-COVID-19 Sequelae | COMPLETED | nan | Campus docent Sant Joan de Déu-Universitat de Barcelona | Telerehabilitation program |
| NCT05739552 | Telerehabilitation in the Post-COVID-19 Patient: the Italy-Switzerland Experience | COMPLETED | nan | Istituto Auxologico Italiano | Telerehabilitation program |
| NCT ID | Title | Status | Phase | Sponsor | Intervention |
|---|---|---|---|---|---|
| NCT06404112 | RECOVER-SLEEP: A Platform Protocol for Evaluation of Interventions for Sleep Disturbances in Post-Acute Sequelae of SARS-CoV-2 Infection (PASC) | COMPLETED | PHASE2 | Duke University | Melatonin; Melantonin Placebo; Tailored lighting (TL) Active; Tailored lighting (TL) Placebo |
| NCT06404086 | RECOVER-SLEEP: A Platform Protocol for Evaluation of Interventions for Sleep Disturbances in Post-Acute Sequelae of SARS-CoV-2 Infection (PASC) | COMPLETED | PHASE2 | Duke University | Modafinil; Modafinil Placebo; Solriamfetol; Solriamfetol Placebo; Melatonin; Melantonin Placebo; Tailored lighting (TL) Active; Tailored lighting (TL) Placebo |
| NCT ID | Title | Status | Phase | Sponsor | Intervention |
|---|---|---|---|---|---|
| NCT06404112 | RECOVER-SLEEP: A Platform Protocol for Evaluation of Interventions for Sleep Disturbances in Post-Acute Sequelae of SARS-CoV-2 Infection (PASC) | COMPLETED | PHASE2 | Duke University | Melatonin; Melantonin Placebo; Tailored lighting (TL) Active; Tailored lighting (TL) Placebo |
| NCT06404086 | RECOVER-SLEEP: A Platform Protocol for Evaluation of Interventions for Sleep Disturbances in Post-Acute Sequelae of SARS-CoV-2 Infection (PASC) | COMPLETED | PHASE2 | Duke University | Modafinil; Modafinil Placebo; Solriamfetol; Solriamfetol Placebo; Melatonin; Melantonin Placebo; Tailored lighting (TL) Active; Tailored lighting (TL) Placebo |
| NCT ID | Title | Status | Phase | Sponsor | Intervention |
|---|---|---|---|---|---|
| NCT04842448 | Hyperbaric Oxygen for Treatment of Long COVID Syndrome; A Randomized, Placebo-Controlled, Double-Blind, Phase II Clinical Trial | COMPLETED | PHASE2 | Karolinska University Hospital | Hyperbaric oxygen; Sham treatment |
| NCT06267300 | Treatment of Post-COVID-19 With Hyperbaric Oxygen Therapy: a Randomized, Controlled Trial | UNKNOWN | PHASE3 | Erasmus Medical Center | Hyperbaric oxygen |
| NCT ID | Title | Status | Phase | Sponsor | Intervention |
|---|---|---|---|---|---|
| NCT05633407 | A Phase 2 Randomized, Double-blinded, Placebo-controlled Study to Evaluate the Efficacy and Safety of Efgartigimod IV in Adult Patients With Post-COVID-19 Postural Orthostatic Tach | COMPLETED | PHASE2 | argenx | Efgartigimod; Placebo |
| NCT05918978 | Open-Label Extension Study to Evaluate the Long-term Safety and Efficacy of Efgartigimod in Adult Patients With Post-COVID-19 Postural Orthostatic Tachycardia Syndrome (PC-POTS) Wh | TERMINATED | PHASE2 | argenx | Efgartigimod |
| NCT ID | Title | Status | Phase | Sponsor | Intervention |
|---|---|---|---|---|---|
| NCT06814379 | Rehabilitation of Fatigue in Patients With Post-COVID-19 Syndrome | COMPLETED | nan | Universidad de Granada | Rehabilitation; Virtual reality based rehabilitation |
| NCT05855356 | The Long-CoviD Patients Causal Diagnosis and Rehabilitation Randomized Feasibility Controlled Trial in Patients With Dysautonomia: the LoCoDiRe-Dys Study | UNKNOWN | nan | Evangelismos Hospital | Rehabilitation; Standard of Care |
| NCT ID | Title | Status | Phase | Sponsor | Intervention |
|---|---|---|---|---|---|
| NCT06251011 | Effects of Physiotherapy Via Telerehabilitation on Cardiopulmonary, Physical, and Psychological Functions in Patients With COVID-19: A Randomized Controlled Trial | COMPLETED | nan | Chulabhorn Hospital | Exercise training |
| NCT05961462 | Effects of Exercise Training on Patients With Long COVID-19, a Single-center, Randomized, Controlled Study | COMPLETED | nan | Guangdong Provincial People's Hospital | Exercise training |
| NCT ID | Title | Status | Phase | Sponsor | Intervention |
|---|---|---|---|---|---|
| NCT07363655 | Effects of a Rehabilitation Programme Focused on Energy Management in People With Myalgic Encephalomyelitis / Chronic Fatigue Syndrome | COMPLETED | nan | Escola Superior de Saúde Norte da Cruz Vermelha Portuguesa | Intervention Group |
| NCT06765421 | Optimising General Practice Long COVID Care - Feasibility Trial of a Pilot Educational Intervention. | NOT_YET_RECRUITING | nan | University College Dublin | Intervention Group |
| NCT ID | Title | Status | Phase | Sponsor | Intervention |
|---|---|---|---|---|---|
| NCT05356936 | Pilot Study of Vitamin K2 (MK-7) and Vitamin D3 Supplementation and the Effects on PASC Symptomatology and Inflammatory Biomarkers | COMPLETED | nan | University Hospitals Cleveland Medical Center | Vitamin K2 (MK-7); Vitamin D3 |
| NCT05269017 | The Potential Therapeutic Effect of Vitamin D Nasal Drops in the Treatment of Post COVID-19 Parosmia | UNKNOWN | PHASE2 | Menoufia University | Vitamin D3; Budesonide nasal spray |
| NCT ID | Title | Status | Phase | Sponsor | Intervention |
|---|---|---|---|---|---|
| NCT05475743 | Early Effects of a Pain Informed Movement Program in Patients With Post COVID-19 Condition Experiencing Persistent Pain: a Randomized Control Trial | COMPLETED | nan | Universidad de Granada | Pain Informed Movement program; Standard medical care and leaflet education |
| NCT06679218 | Improving Health Status in COVID-19 Long-Hauler Through an Activity Coaching Programme: a Randomized Control Trial | NOT_YET_RECRUITING | nan | Universidad de Granada | Activity Coaching Programme; Standard medical care and leaflet education |
| NCT ID | Title | Status | Phase | Sponsor | Intervention |
|---|---|---|---|---|---|
| NCT06928272 | LC-REVITALIZE - A Long Covid Repurposed Drug Study | RECRUITING | PHASE3 | Douglas D. Fraser | Pirfenidone; Placebo for pirfenidone; Upadacitinib; Placebo for upadacitinib |
| NCT04856111 | A Study of the Efficacy and Safety of Pirfenidone vs. Nintedanib in the Treatment of Fibrotic Lung Disease After Coronavirus Disease-19 Pneumonia | UNKNOWN | PHASE4 | Post Graduate Institute of Medical Education and Research, Chandigarh | Pirfenidone; Nintedanib |
| NCT ID | Title | Status | Phase | Sponsor | Intervention |
|---|---|---|---|---|---|
| NCT05633693 | Impact of Postural Sway on Cardiovascular Control in Pediatric Patients With Syncope | RECRUITING | nan | Simon Fraser University | Counterpressure Maneuvers; Baseline Stand |
| NCT05555771 | Determining the Effectiveness of Counterpressure Maneuvers in Pediatric Patients Presenting With Syncope to the Emergency Department | RECRUITING | nan | Dr. Victoria Claydon | Counterpressure Maneuvers; Usual Care |
| NCT ID | Title | Status | Phase | Sponsor | Intervention |
|---|---|---|---|---|---|
| NCT06635928 | Assessing Fatigue and Attention in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Patients Before and After Treatment With Bright Light Therapy: a Prospective Randomized Contro | COMPLETED | nan | Medical University of Vienna | Bright light therapy |
| NCT05677932 | Bright Light Therapy for Post-COVID-19 Fatigue | COMPLETED | nan | Chinese University of Hong Kong | Bright light therapy; Dim red light therapy |
| NCT ID | Title | Status | Phase | Sponsor | Intervention |
|---|---|---|---|---|---|
| NCT06404047 | RECOVER-ENERGIZE: A Platform Protocol for Evaluation of Interventions for Exercise Intolerance in Post-Acute Sequelae of SARS-CoV-2 Infection (PASC) | COMPLETED | nan | Duke University | Personalized Cardiopulmonary Rehabilitation; Structured Pacing; Education; Usual Care |
| NCT06404060 | RECOVER-ENERGIZE: A Platform Protocol for Evaluation of Interventions for Exercise Intolerance in Post-Acute Sequelae of SARS-CoV-2 Infection (PASC) | ACTIVE_NOT_RECRUITING | nan | Duke University | Personalized Cardiopulmonary Rehabilitation; Education |
| NCT ID | Title | Status | Phase | Sponsor | Intervention |
|---|---|---|---|---|---|
| NCT05630339 | Efficacy and Security of the Magnesium and Vitamin D Combination as Adjuvant Treatment of Post-COVID Syndrome. A Randomised Double-blind Clinical Trial | COMPLETED | nan | Coordinación de Investigación en Salud, Mexico | Magnesium chloride; Vitamin D; Inert placebo |
| NCT05633472 | The Roles of Vitamin D and Microbiome in Children With Post-acute COVID-19 Syndromes (PACS) and Long COVID | COMPLETED | nan | China Medical University Hospital | Vitamin D; Placebo |
| NCT ID | Title | Status | Phase | Sponsor | Intervention |
|---|---|---|---|---|---|
| NCT06631287 | Randomized Double-Blind Placebo-Controlled Trial EValuating Baricitinib on PERSistent NEurologic and Cardiopulmonary Symptoms of Long COVID (REVERSE-LC) | RECRUITING | PHASE3 | Wes Ely | Baricitinib; Placebo |
| NCT05858515 | REVERSE-Long COVID: A Multicenter Randomized, Placebo-Controlled Clinical Trial of Immunomodulation (With Baricitinib) for Long COVID Related Cognitive Impairment and ADRD (Alzheim | WITHDRAWN | PHASE3 | Vanderbilt University Medical Center | Baricitinib 4 MG; Placebo |
| NCT ID | Title | Status | Phase | Sponsor | Intervention |
|---|---|---|---|---|---|
| NCT06095297 | Technique to Enable Return-to-Work by Employees With Long COVID Brain Fog | RECRUITING | nan | University of Alabama at Birmingham | Processing Speed Training; In-lab Instrumental Activities of Daily Living Training; In-lab Brain Health Training; Transfer Package; Follow Up Phone Calls; Vocat |
| NCT07523113 | Brain Training for Chronic, Post-viral, Brain Fog: Study A | NOT_YET_RECRUITING | nan | University of Alabama at Birmingham | Processing Speed Training; In-session Instrumental Activities of Daily Living Training; Transfer Package; Follow Up Phone Calls; Trans-auricular Vagus Nerve Sti |
| NCT ID | Title | Status | Phase | Sponsor | Intervention |
|---|---|---|---|---|---|
| NCT05967052 | Investigation of Pregabalin Therapy and Complex Rehabilitation in Treating Chronic Fatigue Associated With Post-COVID Syndrome | RECRUITING | PHASE2 | National Institute of Geriatrics, Rheumatology and Rehabilitation, Poland | Pregabalin; Independent walking training; Placebo; Gradual movement therapy in the ward; Telerehabilitation; Psychotherapy |
| NCT05817032 | Effect of Telerehabilitation Practice in Long COVID-19 Patients: Impact on Stress Oxidative, Inflammation, Functional Capacity and Quality of Life | UNKNOWN | nan | Indonesia University | Telerehabilitation; Standard rehabilitation care |
| NCT ID | Title | Status | Phase | Sponsor | Intervention |
|---|---|---|---|---|---|
| NCT05967052 | Investigation of Pregabalin Therapy and Complex Rehabilitation in Treating Chronic Fatigue Associated With Post-COVID Syndrome | RECRUITING | PHASE2 | National Institute of Geriatrics, Rheumatology and Rehabilitation, Poland | Pregabalin; Independent walking training; Placebo; Gradual movement therapy in the ward; Telerehabilitation; Psychotherapy |
| NCT06042751 | Randomized Comparison of a Telemedicine-supported Psychosomatic Intervention, a Physical Activity Intervention and the Combination of Both in Patients With Post-covid19 Syndrom. | ACTIVE_NOT_RECRUITING | nan | Hannover Medical School | Exercise Therapy; Psychotherapy |
| NCT ID | Title | Status | Phase | Sponsor | Intervention |
|---|---|---|---|---|---|
| NCT06042751 | Randomized Comparison of a Telemedicine-supported Psychosomatic Intervention, a Physical Activity Intervention and the Combination of Both in Patients With Post-covid19 Syndrom. | ACTIVE_NOT_RECRUITING | nan | Hannover Medical School | Exercise Therapy; Psychotherapy |
| NCT04958161 | Reconditioning Exercise for COVID-19 Patients Experiencing Residual sYmptoms | WITHDRAWN | nan | Wake Forest University Health Sciences | Exercise Therapy |
| NCT ID | Title | Status | Phase | Sponsor | Intervention |
|---|---|---|---|---|---|
| NCT06968104 | Stimulation of the Transcutaneous Auricular Vagus Nerve for Improvement of Symptoms in Patients With Post-COVID Syndrome and ME/CFS | ACTIVE_NOT_RECRUITING | nan | University of Luxembourg | transcutaneous vagus nerve stimulation; transcutaneous vagus nerve stimulation |
| NCT06510985 | Transcutaneous Vagus Nerve Stimulation (tVNS) for Improved Recovery After Exertion in Patients With Long/Post-COVID. | NOT_YET_RECRUITING | nan | University Hospital Tuebingen | transcutaneous vagus nerve stimulation; Monitoring; cardiowatch bracelet |
| NCT ID | Title | Status | Phase | Sponsor | Intervention |
|---|---|---|---|---|---|
| NCT06928480 | Effectiveness and Acceptability of the Unified Protocol for the Transdiagnostic Treatment of Emotional Disorders in People With Long COVID-19. | RECRUITING | nan | Instituto de Investigación Sanitaria Aragón | Unified Protocol for the Transdiagnostic Treatment of Emotional Disorders; Treatment as Usual (TAU) |
| NCT04593225 | Effectiveness of Virtual Multicomponent Treatment for Chronic Fatigue Syndrome: VIRTUAL SFCAMINA STUDY | UNKNOWN | nan | Hospital Universitari Vall d'Hebron Research Institute | TAU + multicomponent treatment VIRTUAL SFCAMINA; Treatment as Usual (TAU) |
| NCT ID | Title | Status | Phase | Sponsor | Intervention |
|---|---|---|---|---|---|
| NCT07019519 | Interplay Between Gut Hormones and Autonomic Postprandial Blood Flow Regulation in Patients With POTS | RECRUITING | nan | University of Copenhagen | Saline/Placebo; GIPR antagonist; GLP-1R antagonist; CCK agonist |
| NCT05116761 | Bone Marrow Mesenchymal Stem Cell Derived Extracellular Vesicles Infusion Treatment for Post-Acute and Chronic Post-COVID-19 Syndrome: A Phase I/II Clinical Trial | WITHDRAWN | PHASE1; PHASE2 | Direct Biologics, LLC | Bone Marrow Mesenchymal Stem Cell Derived Extracellular Vesicles; Saline |
| NCT ID | Title | Status | Phase | Sponsor | Intervention |
|---|---|---|---|---|---|
| NCT05554107 | The Effect of Physical Activity on Postural Orthostatic Tachycardia Syndrome | RECRUITING | nan | Lund University | Training program |
| NCT04702217 | Physical Activity as a Complementary Treatment in Postural Orthostatic Tachycardia Syndrome - Evaluation of a Structured Physical Activity Program in Clinical Practice | WITHDRAWN | nan | Lund University | Training program |
| NCT ID | Title | Status | Phase | Sponsor | Intervention |
|---|---|---|---|---|---|
| NCT06095297 | Technique to Enable Return-to-Work by Employees With Long COVID Brain Fog | RECRUITING | nan | University of Alabama at Birmingham | Processing Speed Training; In-lab Instrumental Activities of Daily Living Training; In-lab Brain Health Training; Transfer Package; Follow Up Phone Calls; Vocat |
| NCT07523113 | Brain Training for Chronic, Post-viral, Brain Fog: Study A | NOT_YET_RECRUITING | nan | University of Alabama at Birmingham | Processing Speed Training; In-session Instrumental Activities of Daily Living Training; Transfer Package; Follow Up Phone Calls; Trans-auricular Vagus Nerve Sti |
| NCT ID | Title | Status | Phase | Sponsor | Intervention |
|---|---|---|---|---|---|
| NCT06915324 | Transcranial Direct Current Stimulation (tDCS) of Brain Fog in Patients With Post Treatment Lyme Disease | RECRUITING | nan | Columbia University | Transcranial Direct Current Stimulation (tDCS); Cognitive training |
| NCT06074848 | Transcranial Direct Current Stimulation as a Strategy for the Management of Disorders Generated by COVID-19: a Multicentric Study. | UNKNOWN | PHASE2 | Universidade Federal de Pernambuco | Transcranial Direct Current Stimulation (tDCS); Motor Training; Cognitive Training |
| NCT ID | Title | Status | Phase | Sponsor | Intervention |
|---|---|---|---|---|---|
| NCT05725538 | Efficacy of Exercise-based mHealth Intervention for Patients With Post-acute COVID-19 Syndrome Based on Fatigue, Fitness, Post-exertional Dyspnea, Pain, Anxiety, Depression, Cognit | UNKNOWN | nan | University of Cadiz | COVIDReApp Group; Control Group |
| NCT06374446 | Investigation of the Effect of Virtual Reality on Fatigue, Functional Capacity and Respiratory Function in Patients With Long Covid-19 | UNKNOWN | nan | Istinye University | Classical Treatment; Virtual Reality Combined with Classical Treatment; Virtual Reality; Control Group |
| NCT ID | Title | Status | Phase | Sponsor | Intervention |
|---|---|---|---|---|---|
| NCT04363606 | Chronic Fatigue Etiology and Recovery in Covid-19 Patients : the Role of Fatigability and Stay in Intensive Care | TERMINATED | nan | Centre Hospitalier Universitaire de Saint Etienne | Questionnaires; blood test; Maximal effort test; actigraphy; Neuromuscular evaluation; stool analysis; food diary |
| NCT03849326 | Chronic Fatigue Etiology in Intensive Care Unit Survivors: the Role of Neuromuscular Function | WITHDRAWN | nan | Centre Hospitalier Universitaire de Saint Etienne | Questionnaires; blood test; Maximal effort test; actigraphy; Neuromuscular evaluation |
| NCT ID | Title | Status | Phase | Sponsor | Intervention |
|---|---|---|---|---|---|
| NCT04363606 | Chronic Fatigue Etiology and Recovery in Covid-19 Patients : the Role of Fatigability and Stay in Intensive Care | TERMINATED | nan | Centre Hospitalier Universitaire de Saint Etienne | Questionnaires; blood test; Maximal effort test; actigraphy; Neuromuscular evaluation; stool analysis; food diary |
| NCT03849326 | Chronic Fatigue Etiology in Intensive Care Unit Survivors: the Role of Neuromuscular Function | WITHDRAWN | nan | Centre Hospitalier Universitaire de Saint Etienne | Questionnaires; blood test; Maximal effort test; actigraphy; Neuromuscular evaluation |
| NCT ID | Title | Status | Phase | Sponsor | Intervention |
|---|---|---|---|---|---|
| NCT06095297 | Technique to Enable Return-to-Work by Employees With Long COVID Brain Fog | RECRUITING | nan | University of Alabama at Birmingham | Processing Speed Training; In-lab Instrumental Activities of Daily Living Training; In-lab Brain Health Training; Transfer Package; Follow Up Phone Calls; Vocat |
| NCT07523113 | Brain Training for Chronic, Post-viral, Brain Fog: Study A | NOT_YET_RECRUITING | nan | University of Alabama at Birmingham | Processing Speed Training; In-session Instrumental Activities of Daily Living Training; Transfer Package; Follow Up Phone Calls; Trans-auricular Vagus Nerve Sti |
| NCT ID | Title | Status | Phase | Sponsor | Intervention |
|---|---|---|---|---|---|
| NCT06095297 | Technique to Enable Return-to-Work by Employees With Long COVID Brain Fog | RECRUITING | nan | University of Alabama at Birmingham | Processing Speed Training; In-lab Instrumental Activities of Daily Living Training; In-lab Brain Health Training; Transfer Package; Follow Up Phone Calls; Vocat |
| NCT07523113 | Brain Training for Chronic, Post-viral, Brain Fog: Study A | NOT_YET_RECRUITING | nan | University of Alabama at Birmingham | Processing Speed Training; In-session Instrumental Activities of Daily Living Training; Transfer Package; Follow Up Phone Calls; Trans-auricular Vagus Nerve Sti |
| NCT ID | Title | Status | Phase | Sponsor | Intervention |
|---|---|---|---|---|---|
| NCT06095297 | Technique to Enable Return-to-Work by Employees With Long COVID Brain Fog | RECRUITING | nan | University of Alabama at Birmingham | Processing Speed Training; In-lab Instrumental Activities of Daily Living Training; In-lab Brain Health Training; Transfer Package; Follow Up Phone Calls; Vocat |
| NCT07523113 | Brain Training for Chronic, Post-viral, Brain Fog: Study A | NOT_YET_RECRUITING | nan | University of Alabama at Birmingham | Processing Speed Training; In-session Instrumental Activities of Daily Living Training; Transfer Package; Follow Up Phone Calls; Trans-auricular Vagus Nerve Sti |
| NCT ID | Title | Status | Phase | Sponsor | Intervention |
|---|---|---|---|---|---|
| NCT05338749 | An Open-label Trial of Computer-delivered Cognitive Training in Persons With Post-acute COVID-19 Syndrome | COMPLETED | nan | Nova Southeastern University | Cognitive Training |
| NCT06074848 | Transcranial Direct Current Stimulation as a Strategy for the Management of Disorders Generated by COVID-19: a Multicentric Study. | UNKNOWN | PHASE2 | Universidade Federal de Pernambuco | Transcranial Direct Current Stimulation (tDCS); Motor Training; Cognitive Training |
| NCT ID | Title | Status | Phase | Sponsor | Intervention |
|---|---|---|---|---|---|
| NCT06928116 | Physical Rehabilitation of Long COVID by Heat Therapy | RECRUITING | nan | University of Nebraska | Heat therapy; Sham Control; Walking |
| NCT05289128 | Predicting Outcomes From HD-tDCS Intervention in Long COVID-19 Using Electroencephalographic Biomarkers and Machine Learning Approach. | UNKNOWN | nan | Federal University of Paraíba | Experimental group; Sham Control |
| NCT ID | Title | Status | Phase | Sponsor | Intervention |
|---|---|---|---|---|---|
| NCT04363606 | Chronic Fatigue Etiology and Recovery in Covid-19 Patients : the Role of Fatigability and Stay in Intensive Care | TERMINATED | nan | Centre Hospitalier Universitaire de Saint Etienne | Questionnaires; blood test; Maximal effort test; actigraphy; Neuromuscular evaluation; stool analysis; food diary |
| NCT03849326 | Chronic Fatigue Etiology in Intensive Care Unit Survivors: the Role of Neuromuscular Function | WITHDRAWN | nan | Centre Hospitalier Universitaire de Saint Etienne | Questionnaires; blood test; Maximal effort test; actigraphy; Neuromuscular evaluation |
| NCT ID | Title | Status | Phase | Sponsor | Intervention |
|---|---|---|---|---|---|
| NCT04363606 | Chronic Fatigue Etiology and Recovery in Covid-19 Patients : the Role of Fatigability and Stay in Intensive Care | TERMINATED | nan | Centre Hospitalier Universitaire de Saint Etienne | Questionnaires; blood test; Maximal effort test; actigraphy; Neuromuscular evaluation; stool analysis; food diary |
| NCT03849326 | Chronic Fatigue Etiology in Intensive Care Unit Survivors: the Role of Neuromuscular Function | WITHDRAWN | nan | Centre Hospitalier Universitaire de Saint Etienne | Questionnaires; blood test; Maximal effort test; actigraphy; Neuromuscular evaluation |
| NCT ID | Title | Status | Phase | Sponsor | Intervention |
|---|---|---|---|---|---|
| NCT06095297 | Technique to Enable Return-to-Work by Employees With Long COVID Brain Fog | RECRUITING | nan | University of Alabama at Birmingham | Processing Speed Training; In-lab Instrumental Activities of Daily Living Training; In-lab Brain Health Training; Transfer Package; Follow Up Phone Calls; Vocat |
| NCT07523113 | Brain Training for Chronic, Post-viral, Brain Fog: Study A | NOT_YET_RECRUITING | nan | University of Alabama at Birmingham | Processing Speed Training; In-session Instrumental Activities of Daily Living Training; Transfer Package; Follow Up Phone Calls; Trans-auricular Vagus Nerve Sti |
| NCT ID | Title | Status | Phase | Sponsor | Intervention |
|---|---|---|---|---|---|
| NCT04363606 | Chronic Fatigue Etiology and Recovery in Covid-19 Patients : the Role of Fatigability and Stay in Intensive Care | TERMINATED | nan | Centre Hospitalier Universitaire de Saint Etienne | Questionnaires; blood test; Maximal effort test; actigraphy; Neuromuscular evaluation; stool analysis; food diary |
| NCT03849326 | Chronic Fatigue Etiology in Intensive Care Unit Survivors: the Role of Neuromuscular Function | WITHDRAWN | nan | Centre Hospitalier Universitaire de Saint Etienne | Questionnaires; blood test; Maximal effort test; actigraphy; Neuromuscular evaluation |
| NCT ID | Title | Status | Phase | Sponsor | Intervention |
|---|---|---|---|---|---|
| NCT07357688 | The Effect of Acupuncture Therapy on Cognitive Function in Post-COVID-19 Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Study With Multimodal Magnetic Resonance Imaging | NOT_YET_RECRUITING | nan | Xi Wu | Acupuncture; Sham acupuncture |
| NCT07355751 | The Effect of Acupuncture Treatment on Cognitive Functions and Brain Networks for Long COVID: a Multimodal Magnetic Resonance Imaging Study | NOT_YET_RECRUITING | nan | Tingting Luo | Acupuncture; Sham acupuncture |
| NCT ID | Title | Status | Phase | Sponsor | Intervention |
|---|---|---|---|---|---|
| NCT04905888 | Hyperbaric Oxygen Therapy for Long COVID Patients With Pulmonary Sequela - Pilot Study | WITHDRAWN | PHASE2 | Peter Lindholm | Hyperbaric oxygen therapy |
| NCT07621068 | Hyperbaric Oxygen Therapy for Chronic Fatigue Syndrome (CFS) - A Prospective, Randomized, Double-Blind, Sham-Controlled Study | NOT_YET_RECRUITING | nan | Assaf-Harofeh Medical Center | Hyperbaric oxygen therapy; SHAM treatment |
| NCT ID | Title | Status | Phase | Sponsor | Intervention |
|---|---|---|---|---|---|
| NCT04909892 | A Phase 2a Study of Intravenous Allogeneic Adipose-Derived Mesenchymal Stem Cells to Treat Post COVID-19 "Long Haul" Pulmonary Compromise | WITHDRAWN | PHASE2 | Sorrento Therapeutics, Inc. | COVI-MSC |
| NCT04992247 | A Phase 2A Randomized, Placebo-Controlled Study of Intravenous Allogeneic Adipose-Derived Mesenchymal Stem Cells to Treat Post COVID-19 "Long Haul" Pulmonary Compromise | WITHDRAWN | PHASE2 | Sorrento Therapeutics, Inc. | COVI-MSC; Placebo |
| NCT ID | Title | Status | Phase | Sponsor | Intervention |
|---|---|---|---|---|---|
| NCT05012826 | Osteopathy and Physiotherapy Compared to Physiotherapy Alone on Fatigue and Functional Status in Long COVID: Study Protocol for a Pragmatic Randomized Controlled SuperiorityTrial | UNKNOWN | nan | Centro Universitário Augusto Motta | Osteopathic Manipulative Treatment in addition to Physiotherapy; Physiotherapy |
| NCT05040893 | A Pilot Feasibility Study of a Physiotherapy-based Tailored Intervention for Long COVID. | UNKNOWN | nan | University of Calgary | Physiotherapy |
| NCT ID | Title | Status | Phase | Sponsor | Intervention |
|---|---|---|---|---|---|
| NCT04947488 | Evaluation of the Effects of Treatment With Bioarginin C on Physical Exhaustion , Systemic Inflammatory State and Endothelial Function in Adult Subjects Belonging to the Post-Covid | UNKNOWN | nan | University of Milan | Bioarginina C |
| NCT06865261 | Effects of L-arginine and Liposomal Vitamin C Supplementation on Physical Performance and Endothelial Function in Elderly With Sarcopenia | UNKNOWN | nan | Fondazione Policlinico Universitario Agostino Gemelli IRCCS | Bioarginina C; Placebo |
| NCT ID | Title | Status | Phase | Sponsor | Intervention |
|---|---|---|---|---|---|
| NCT05074888 | A Multicenter, Double-blind, Placebo-controlled, Parallel-group, Randomized Clinical Trial of Efficacy and Safety of Prospekta in the Treatment of Patients With Post-COVID-19 Asthe | COMPLETED | PHASE3 | Materia Medica Holding | Prospekta; Placebo |
| NCT ID | Title | Status | Phase | Sponsor | Intervention |
|---|---|---|---|---|---|
| NCT05104749 | Homeopathic Treatment of Post-acute COVID-19 Syndrome- A Pilot Randomized Controlled Trial | COMPLETED | PHASE3 | Southwest College of Naturopathic Medicine | Homeopathic Medication; Placebo |
| NCT ID | Title | Status | Phase | Sponsor | Intervention |
|---|---|---|---|---|---|
| NCT04510194 | COVID-OUT: Early Outpatient Treatment for SARS-CoV-2 Infection (COVID-19) | COMPLETED | PHASE3 | University of Minnesota | Metformin; Placebo; Fluvoxamine; Ivermectin |
| NCT ID | Title | Status | Phase | Sponsor | Intervention |
|---|---|---|---|---|---|
| NCT05212610 | Assessing Safety of COVID-19 mRNA Vaccine Administration in the Setting of a Previous Adverse Reaction | COMPLETED | PHASE4 | University of Michigan | Pfizer-BioNTech mRNA COVID-19 vaccine; Moderna mRNA COVID-19 vaccine |
| NCT ID | Title | Status | Phase | Sponsor | Intervention |
|---|---|---|---|---|---|
| NCT05212610 | Assessing Safety of COVID-19 mRNA Vaccine Administration in the Setting of a Previous Adverse Reaction | COMPLETED | PHASE4 | University of Michigan | Pfizer-BioNTech mRNA COVID-19 vaccine; Moderna mRNA COVID-19 vaccine |
| NCT ID | Title | Status | Phase | Sponsor | Intervention |
|---|---|---|---|---|---|
| NCT05592418 | A Randomized, Double Blind, Placebo Controlled Study to Evaluate the Efficacy and Safety of Ampligen® in Patients With Post-COVID Conditions | COMPLETED | PHASE2 | AIM ImmunoTech Inc. | Rintatolimod; Placebo / Normal Saline |
| NCT ID | Title | Status | Phase | Sponsor | Intervention |
|---|---|---|---|---|---|
| NCT04871815 | Preliminary Examination of the Effects of Sodium Pyruvate Nasal Spray (N115) on Symptoms Associated With COVID19 Long Haulers. | COMPLETED | PHASE2; PHASE3 | Cellular Sciences, inc. | sodium pyruvate nasal spray |
| NCT ID | Title | Status | Phase | Sponsor | Intervention |
|---|---|---|---|---|---|
| NCT05047952 | Randomized, Double-Blinded, Placebo-Controlled Study Evaluating Vortioxetine for Cognitive Deficits in Persons With Post-COVID-19 Condition | COMPLETED | PHASE2 | Brain and Cognition Discovery Foundation | Vortioxetine; Placebo |
| NCT ID | Title | Status | Phase | Sponsor | Intervention |
|---|---|---|---|---|---|
| NCT05970731 | Directed Topical Drug Delivery for Treatment for PASC Hyposmia | COMPLETED | PHASE2 | Duke University | Beclomethasone; Placebo; Microsponge |
| NCT ID | Title | Status | Phase | Sponsor | Intervention |
|---|---|---|---|---|---|
| NCT05970731 | Directed Topical Drug Delivery for Treatment for PASC Hyposmia | COMPLETED | PHASE2 | Duke University | Beclomethasone; Placebo; Microsponge |
| NCT ID | Title | Status | Phase | Sponsor | Intervention |
|---|---|---|---|---|---|
| NCT04920916 | Safety and Efficacy of the Treatment of Hospitalized Patients With COVID 19 Infection With an Inhibitor of IL-4 and IL-13 Signaling: A Phase IIa Trial | COMPLETED | PHASE2 | University of Virginia | Dupilumab; Placebo |
| NCT ID | Title | Status | Phase | Sponsor | Intervention |
|---|---|---|---|---|---|
| NCT05999435 | A DOUBLE-BLIND, RANDOMIZED, PLACEBO-CONTROLLED, ADAPTIVE PHASE 2/3 STUDY OF THE EFFICACY OF LAU-7b IN THE TREATMENT OF ADULTS WITH LONG COVID AND MODERATE TO SEVERE SYMPTOMS | COMPLETED | PHASE2; PHASE3 | Laurent Pharmaceuticals Inc. | LAU-7b for 3 cycles; LAU-7b for 1 cycle, then placebo; Placebo for 3 cycles |
| NCT ID | Title | Status | Phase | Sponsor | Intervention |
|---|---|---|---|---|---|
| NCT05121740 | Extension Study in a Cohort of Adult Patients With SARS-CoV-2 Infection Requiring Hospital Admission and Received Treatment With Plitidepsin in the APLICOV-PC Study | COMPLETED | PHASE1; PHASE2 | PharmaMar | Plitidepsin 1.5 mg / day; Plitidepsin 2.0 mg / day; Plitidepsin 2.5 mg / day |
This chart restricts the denominator to CT.gov trials whose intervention_types include DRUG (195 trials). Bars count only intervention names whose paired CT.gov intervention_type is DRUG. Intervention names are cleaned and mapped to canonical therapy labels using an external normalization dictionary where available. Each trial contributes at most once per normalized drug concept. For readability and dashboard performance, the chart shows the top 100 of 223 detected normalized DRUG concepts.
| NCT ID | Title | Status | Phase | Sponsor | Intervention |
|---|---|---|---|---|---|
| NCT05576662 | Selective Trial Of Paxlovid for PASC (STOP-PASC): Randomized Double-Blind Placebo-Controlled Pilot Trial of Paxlovid for the Treatment of PASC | COMPLETED | PHASE2 | Stanford University | Nirmatrelvir; Placebo; Ritonavir |
| NCT05965726 | RECOVER-VITAL: A Platform Protocol for Evaluation of Interventions for Viral Persistence, Viral Reactivation, and Immune Dysregulation in Post-Acute Sequelae of SARS-CoV-2 Infectio | COMPLETED | PHASE2 | Kanecia Obie Zimmerman | Paxlovid; Ritonavir; Nirmatrelvir-matching placebo |
| NCT05595369 | RECOVER-VITAL: A Platform Protocol for Evaluation of Interventions for Viral Persistence, Viral Reactivation, and Immune Dysregulation in Post-Acute Sequelae of SARS-CoV-2 Infectio | COMPLETED | PHASE2 | Kanecia Obie Zimmerman | Experimental: Paxlovid 25 day dosing; Experimental: Paxlovid 15 day dosing; Placebo Comparator: Control |
| NCT05668091 | An Interventional Decentralized Phase 2, Randomized, Double-Blind, 2-Arm Study to Investigate the Efficacy and Safety of Orally Administered Nirmatrelvir/Ritonavir Compared with Pl | COMPLETED | PHASE2 | Harlan M Krumholz | Nirmatrelvir; Ritonavir; Placebo |
| NCT05823896 | An Interventional, Double-Blinded, 2-Arm Study to Investigate the Efficacy of Orally Administered Nirmatrelvir/Ritonavir Compared with Placebo/Ritonavir in Non-hospitalized Adult P | COMPLETED | PHASE2 | Karolinska Institutet | Nirmatrelvir/ritonavir; Placebo/ritonavir |
| NCT05852873 | PAxlovid loNg cOvid-19 pRevention triAl With recruitMent In the Community in Norway | ACTIVE_NOT_RECRUITING | PHASE3 | Haukeland University Hospital | Nirmatrelvir/ritonavir; Placebo |
| NCT06441955 | Covid-19 Long Haul Syndrome: Undiagnosed Disorder Post Covid-19 Alternative Treatment Study. | RECRUITING | PHASE4 | Well- Konnect Healthcare Services and Research Firm | Ritonavir-Boosted Nirmatrelvir (Paxlovid); Physiological Evaluation; Moderna COVID-19 Vaccine; Biopsychological; Behavioral (e.g., Psychotherapy, Lifestyle Coun |
| NCT06792214 | Antiviral Strategies in the Prevention of Long-term Cardiovascular Outcomes Following COVID-19: The paxloviD/Remdesivir Effectiveness For the prEvention of loNg coviD (DEFEND) Clin | RECRUITING | PHASE4 | Mount Sinai Hospital, Canada | Nirmatrelvir/ritonavir; Remdesivir |
| NCT07597902 | SARS-CoV-2 and Herpesvirus Inhibition for Ending Long COVID Dysfunction (SHIELD) | NOT_YET_RECRUITING | PHASE2 | Icahn School of Medicine at Mount Sinai | Valacyclovir; Celecoxib; Paxlovid; Placebo |
| NCT ID | Title | Status | Phase | Sponsor | Intervention |
|---|---|---|---|---|---|
| NCT04510194 | COVID-OUT: Early Outpatient Treatment for SARS-CoV-2 Infection (COVID-19) | COMPLETED | PHASE3 | University of Minnesota | Metformin; Placebo; Fluvoxamine; Ivermectin |
| NCT07280572 | RECLAIM: an Adaptive Platform Trial for the Evaluation of Treatments for Post-Acute Sequelae of SARS-CoV-2 Infection (PASC) | ENROLLING_BY_INVITATION | PHASE3 | Janneke van de Wijgert | Metformin; colchicine |
| NCT06147050 | Pilot Study of an Adaptive, Double-blind, Randomized, Placebo-controlled Study to Evaluate the Effect of Metformin in Reducing Fatigue in Long COVID Adolescent Patients With Chroni | UNKNOWN | PHASE3 | Purpose Life Sciences | Metformin; Placebo |
| NCT ID | Title | Status | Phase | Sponsor | Intervention |
|---|---|---|---|---|---|
| NCT04510194 | COVID-OUT: Early Outpatient Treatment for SARS-CoV-2 Infection (COVID-19) | COMPLETED | PHASE3 | University of Minnesota | Metformin; Placebo; Fluvoxamine; Ivermectin |
| NCT05874037 | Fluvoxamine as a Treatment for Long COVID-19: A Randomized Placebo Controlled Trial | COMPLETED | PHASE2; PHASE3 | Washington University School of Medicine | Fluvoxamine |
| NCT07359482 | sElective Serotonin reuPtake inhibitoRs In posT-covid: ESPRIT | NOT_YET_RECRUITING | PHASE3 | Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) | Fluvoxamine; Placebo |
| NCT ID | Title | Status | Phase | Sponsor | Intervention |
|---|---|---|---|---|---|
| NCT05638633 | Prednisolone and Vitamin B1, B6, and B12 in Patients With Post-COVID-19-Syndrome (PC19S) - a Randomized Controlled Trial in Primary Care | COMPLETED | PHASE3 | Wuerzburg University Hospital | Prednisolone 20 mg/ 5 mg; Vitamin B compound (100mg B1, 50 mg B6, 500 µg B12); Placebo for Vitamin B compound; Placebo for Prednisolon |
| NCT05619653 | Randomised Placebo Controlled Clinical Trial of Efficacy of MYOcardial Protection in Patients With Postacute inFLAMmatory Cardiac involvEment Due to COVID-19 | ACTIVE_NOT_RECRUITING | PHASE3 | Valentina Puentmann | Prednisolone; Losartan |
| NCT07380152 | Corticosteroid Treatment for Post-COVID-19 Persistent Interstitial Lung Disease | COMPLETED | PHASE1 | University of Sao Paulo | Prednisolone |
| NCT ID | Title | Status | Phase | Sponsor | Intervention |
|---|---|---|---|---|---|
| NCT06305780 | RECOVER-AUTONOMIC: A Platform Protocol for Evaluation of Interventions for Autonomic Dysfunction in Post-Acute Sequelae of SARS-CoV-2 Infection (PASC) | COMPLETED | PHASE2 | Kanecia Obie Zimmerman | IVIG + Coordinated Care; IVIG Placebo + Coordinated Care; Ivabradine + Coordinated Care; Ivabradine Placebo + Coordinated Care; IVIG + Usual Care; IVIG Placebo |
| NCT06305806 | RECOVER-AUTONOMIC (Ivabradine): Randomized Trial of the Effect of Ivabradine Versus Placebo on Long COVID Symptoms | COMPLETED | PHASE2 | Kanecia Obie Zimmerman | Ivabradine; Ivabradine Placebo; Coordinated Care; Usual Care |
| NCT05481177 | Comparative Cohort Study of Post-acute COVID-19 Infection With a Nested, Randomized Controlled Trial of Ivabradine for Those With Postural Orthostatic Tachycardia Syndrome. | UNKNOWN | PHASE4 | Uniformed Services University of the Health Sciences | Ivabradine |
| NCT ID | Title | Status | Phase | Sponsor | Intervention |
|---|---|---|---|---|---|
| NCT06305780 | RECOVER-AUTONOMIC: A Platform Protocol for Evaluation of Interventions for Autonomic Dysfunction in Post-Acute Sequelae of SARS-CoV-2 Infection (PASC) | COMPLETED | PHASE2 | Kanecia Obie Zimmerman | IVIG + Coordinated Care; IVIG Placebo + Coordinated Care; Ivabradine + Coordinated Care; Ivabradine Placebo + Coordinated Care; IVIG + Usual Care; IVIG Placebo |
| NCT06305793 | RECOVER-AUTONOMIC (IVIG): Randomized Trial of the Effect of IVIG Versus Placebo on Long COVID Symptoms | ACTIVE_NOT_RECRUITING | PHASE2 | Kanecia Obie Zimmerman | IVIG (intravenous immunoglobulin); IVIG Placebo; Coordinated Care; Usual Care |
| NCT05350774 | Immunotherapy for Neurological Post-Acute Sequelae of SARS-CoV-2 (IN-PASC) | ENROLLING_BY_INVITATION | PHASE2 | National Institute of Neurological Disorders and Stroke (NINDS) | IV normal saline; IV immunoglobulin |
| NCT ID | Title | Status | Phase | Sponsor | Intervention |
|---|---|---|---|---|---|
| NCT06055244 | Amantadine Therapy for Cognitive Impairment Related to Post-COVID Condition | COMPLETED | PHASE2 | Ohio State University | Amantadine |
| NCT06234462 | Feasibility Study of Amantadine for Cognitive Dysfunction in Patients With Long-Covid: A Pilot Randomized Control Trial | WITHDRAWN | PHASE2 | University of Texas Southwestern Medical Center | Amantadine; Physical, Occupational, Speech Therapy; Provider Counseling; Medications for symptoms management |
| NCT05667077 | The Effect of Amantadine on Post-COVD-19 Fatigue: a Clinical Trial | UNKNOWN | PHASE2 | Shahid Beheshti University of Medical Sciences | Amantadine |
| NCT ID | Title | Status | Phase | Sponsor | Intervention |
|---|---|---|---|---|---|
| NCT04904536 | An International, Investigator Initiated and Conducted, Pragmatic Clinical Trial to Determine Whether 40mg Atorvastatin Daily Can Improve Neurocognitive Function in Adults With Lon | ACTIVE_NOT_RECRUITING | PHASE3 | The George Institute | Atorvastatin; Standard Care |
| NCT06974084 | A Multi-Center Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy of Maraviroc and Atorvastatin for the Treatment of Subjects With Long COVID/Post-Acute Se | NOT_YET_RECRUITING | PHASE2; PHASE3 | HealthBio, Inc. | Maraviroc (MVC); Atorvastatin, 10mg, 20mg, 40mg; Placebo, Maraviroc; Placebo, Atorvastatin |
| NCT04801940 | HElping Alleviate the Longer-term Consequences of COVID-19 (HEAL-COVID): a National Platform Trial | UNKNOWN | PHASE3 | Cambridge University Hospitals NHS Foundation Trust | Apixaban; Atorvastatin |
| NCT ID | Title | Status | Phase | Sponsor | Intervention |
|---|---|---|---|---|---|
| NCT05430152 | A Double Blind Randomized Trial of Low-dose Naltrexone for Post-COVID Fatigue Syndrome | COMPLETED | PHASE2 | Luis Nacul | Low-Dose Naltrexone; Placebo |
| NCT06366724 | LIFT: Life Improvement Trial | RECRUITING | PHASE2 | Brigham and Women's Hospital | Pyridostigmine; Low-Dose Naltrexone; Placebo |
| NCT07285473 | Low-dose Naltrexone (LDN) for the Treatment of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS): Dose-Finding | NOT_YET_RECRUITING | PHASE2 | University of Alabama at Birmingham | Low-Dose Naltrexone, 1.5mg; Low-Dose Naltrexone, 3.0mg; Low-Dose Naltrexone, 4.5mg; Low-Dose Naltrexone, 6.0mg |
| NCT ID | Title | Status | Phase | Sponsor | Intervention |
|---|---|---|---|---|---|
| NCT06404112 | RECOVER-SLEEP: A Platform Protocol for Evaluation of Interventions for Sleep Disturbances in Post-Acute Sequelae of SARS-CoV-2 Infection (PASC) | COMPLETED | PHASE2 | Duke University | Melatonin; Melantonin Placebo; Tailored lighting (TL) Active; Tailored lighting (TL) Placebo |
| NCT06404086 | RECOVER-SLEEP: A Platform Protocol for Evaluation of Interventions for Sleep Disturbances in Post-Acute Sequelae of SARS-CoV-2 Infection (PASC) | COMPLETED | PHASE2 | Duke University | Modafinil; Modafinil Placebo; Solriamfetol; Solriamfetol Placebo; Melatonin; Melantonin Placebo; Tailored lighting (TL) Active; Tailored lighting (TL) Placebo |
| NCT ID | Title | Status | Phase | Sponsor | Intervention |
|---|---|---|---|---|---|
| NCT05633407 | A Phase 2 Randomized, Double-blinded, Placebo-controlled Study to Evaluate the Efficacy and Safety of Efgartigimod IV in Adult Patients With Post-COVID-19 Postural Orthostatic Tach | COMPLETED | PHASE2 | argenx | Efgartigimod; Placebo |
| NCT05918978 | Open-Label Extension Study to Evaluate the Long-term Safety and Efficacy of Efgartigimod in Adult Patients With Post-COVID-19 Postural Orthostatic Tachycardia Syndrome (PC-POTS) Wh | TERMINATED | PHASE2 | argenx | Efgartigimod |
| NCT ID | Title | Status | Phase | Sponsor | Intervention |
|---|---|---|---|---|---|
| NCT06133075 | Using Mirabegron to Increase Blood Pressure in Patients With Postural Orthostatic Tachycardia Syndrome | COMPLETED | PHASE2 | Cedars-Sinai Medical Center | Mirabegron 50 MG; Mirabegron 25 MG |
| NCT07585513 | A Randomized Placebo-Controlled Clinical Trial Evaluating Mirabegron's Effectiveness in Alleviating POTS Symptoms | NOT_YET_RECRUITING | PHASE2 | Cedars-Sinai Medical Center | Mirabegron; Placebo |
| NCT ID | Title | Status | Phase | Sponsor | Intervention |
|---|---|---|---|---|---|
| NCT06253806 | Stellate Ganglion Block for the Treatment of COVID-19-Induced Parosmia: Double-Blinded, Placebo-Controlled Randomized Clinical Trial | COMPLETED | PHASE2 | Washington University School of Medicine | Stellate Ganglion Block; Placebo Sham Injection |
| NCT05445921 | Stellate Ganglion Block for the Treatment of COVID-19-Induced Olfactory Dysfunction: A Prospective Pilot Study | COMPLETED | PHASE1; PHASE2 | Washington University School of Medicine | Stellate Ganglion Block |
| NCT ID | Title | Status | Phase | Sponsor | Intervention |
|---|---|---|---|---|---|
| NCT04313972 | IC PaIN Trial: Interstitial Cystitis Pain Improvement With Naltrexone, the Effect of Low Dose Naltrexone on Symptoms and Pain of Patients With Interstitial Cystitis/Painful Bladder | TERMINATED | PHASE4 | Endeavor Health | low-dose naltrexone; Placebo oral tablet |
| NCT04140721 | Autonomic Determinants of Postural Tachycardia Syndrome (Chronic Pilot Study 2) | ACTIVE_NOT_RECRUITING | EARLY_PHASE1 | Vanderbilt University Medical Center | Placebo oral tablet; Moxonidine Pill |
| NCT ID | Title | Status | Phase | Sponsor | Intervention |
|---|---|---|---|---|---|
| NCT05795816 | The Effectiveness of Testofen on Energy, Fatigue, Mental Acuity, and Other Quality of Life Symptoms Post COVID-19 Infection | COMPLETED | PHASE3 | RDC Clinical Pty Ltd | Testofen; Microcrystalline cellulose |
| NCT05363514 | A Pilot Study of Low Dose Naltrexone Use in Patients With Postural Orthostatic Tachycardia Syndrome | NOT_YET_RECRUITING | PHASE4 | University of Calgary | Low Dose Naltrexone; Microcrystalline cellulose |
| NCT ID | Title | Status | Phase | Sponsor | Intervention |
|---|---|---|---|---|---|
| NCT06404099 | RECOVER-SLEEP: A Platform Protocol for Evaluation of Interventions for Sleep Disturbances in Post-Acute Sequelae of SARS-CoV-2 Infection (PASC) | COMPLETED | PHASE2 | Duke University | Modafinil; Modafinil Placebo; Solriamfetol; Solriamfetol Placebo |
| NCT06404086 | RECOVER-SLEEP: A Platform Protocol for Evaluation of Interventions for Sleep Disturbances in Post-Acute Sequelae of SARS-CoV-2 Infection (PASC) | COMPLETED | PHASE2 | Duke University | Modafinil; Modafinil Placebo; Solriamfetol; Solriamfetol Placebo; Melatonin; Melantonin Placebo; Tailored lighting (TL) Active; Tailored lighting (TL) Placebo |
| NCT ID | Title | Status | Phase | Sponsor | Intervention |
|---|---|---|---|---|---|
| NCT05911906 | An Open-label, Clinical Feasibility Study of the Efficacy of Remdesivir for Long-COVID. | COMPLETED | PHASE4 | University of Derby | Remdesivir |
| NCT06792214 | Antiviral Strategies in the Prevention of Long-term Cardiovascular Outcomes Following COVID-19: The paxloviD/Remdesivir Effectiveness For the prEvention of loNg coviD (DEFEND) Clin | RECRUITING | PHASE4 | Mount Sinai Hospital, Canada | Nirmatrelvir/ritonavir; Remdesivir |
| NCT ID | Title | Status | Phase | Sponsor | Intervention |
|---|---|---|---|---|---|
| NCT06404099 | RECOVER-SLEEP: A Platform Protocol for Evaluation of Interventions for Sleep Disturbances in Post-Acute Sequelae of SARS-CoV-2 Infection (PASC) | COMPLETED | PHASE2 | Duke University | Modafinil; Modafinil Placebo; Solriamfetol; Solriamfetol Placebo |
| NCT06404086 | RECOVER-SLEEP: A Platform Protocol for Evaluation of Interventions for Sleep Disturbances in Post-Acute Sequelae of SARS-CoV-2 Infection (PASC) | COMPLETED | PHASE2 | Duke University | Modafinil; Modafinil Placebo; Solriamfetol; Solriamfetol Placebo; Melatonin; Melantonin Placebo; Tailored lighting (TL) Active; Tailored lighting (TL) Placebo |
| NCT ID | Title | Status | Phase | Sponsor | Intervention |
|---|---|---|---|---|---|
| NCT04842448 | Hyperbaric Oxygen for Treatment of Long COVID Syndrome; A Randomized, Placebo-Controlled, Double-Blind, Phase II Clinical Trial | COMPLETED | PHASE2 | Karolinska University Hospital | Hyperbaric oxygen; Sham treatment |
| NCT06267300 | Treatment of Post-COVID-19 With Hyperbaric Oxygen Therapy: a Randomized, Controlled Trial | UNKNOWN | PHASE3 | Erasmus Medical Center | Hyperbaric oxygen |
| NCT ID | Title | Status | Phase | Sponsor | Intervention |
|---|---|---|---|---|---|
| NCT06928272 | LC-REVITALIZE - A Long Covid Repurposed Drug Study | RECRUITING | PHASE3 | Douglas D. Fraser | Pirfenidone; Placebo for pirfenidone; Upadacitinib; Placebo for upadacitinib |
| NCT04856111 | A Study of the Efficacy and Safety of Pirfenidone vs. Nintedanib in the Treatment of Fibrotic Lung Disease After Coronavirus Disease-19 Pneumonia | UNKNOWN | PHASE4 | Post Graduate Institute of Medical Education and Research, Chandigarh | Pirfenidone; Nintedanib |
| NCT ID | Title | Status | Phase | Sponsor | Intervention |
|---|---|---|---|---|---|
| NCT06631287 | Randomized Double-Blind Placebo-Controlled Trial EValuating Baricitinib on PERSistent NEurologic and Cardiopulmonary Symptoms of Long COVID (REVERSE-LC) | RECRUITING | PHASE3 | Wes Ely | Baricitinib; Placebo |
| NCT05858515 | REVERSE-Long COVID: A Multicenter Randomized, Placebo-Controlled Clinical Trial of Immunomodulation (With Baricitinib) for Long COVID Related Cognitive Impairment and ADRD (Alzheim | WITHDRAWN | PHASE3 | Vanderbilt University Medical Center | Baricitinib 4 MG; Placebo |
| NCT ID | Title | Status | Phase | Sponsor | Intervention |
|---|---|---|---|---|---|
| NCT06952413 | An Exploratory, Placebo-controlled, Double-blind, Phase II Study of the Efficacy and Safety for Rituximab (Genetical Recombination) in Myalgia Encephalomyelitis/Chronic Fatigue Syn | RECRUITING | PHASE2 | National Center of Neurology and Psychiatry, Japan | Rituximab(Genetical Recombination); Placebo |
| NCT05682196 | Open-label, Randomized Controlled Trial to Assess Efficacy and Safety of Rituximab in Patients With Acute Rheumatic Fever in Africa | SUSPENDED | PHASE2 | African Academy of Methodology and Statistics | Rituximab added to standard of care treatment; standard of care treatment alone |
| NCT ID | Title | Status | Phase | Sponsor | Intervention |
|---|---|---|---|---|---|
| NCT06404112 | RECOVER-SLEEP: A Platform Protocol for Evaluation of Interventions for Sleep Disturbances in Post-Acute Sequelae of SARS-CoV-2 Infection (PASC) | COMPLETED | PHASE2 | Duke University | Melatonin; Melantonin Placebo; Tailored lighting (TL) Active; Tailored lighting (TL) Placebo |
| NCT06404086 | RECOVER-SLEEP: A Platform Protocol for Evaluation of Interventions for Sleep Disturbances in Post-Acute Sequelae of SARS-CoV-2 Infection (PASC) | COMPLETED | PHASE2 | Duke University | Modafinil; Modafinil Placebo; Solriamfetol; Solriamfetol Placebo; Melatonin; Melantonin Placebo; Tailored lighting (TL) Active; Tailored lighting (TL) Placebo |
| NCT ID | Title | Status | Phase | Sponsor | Intervention |
|---|---|---|---|---|---|
| NCT05970731 | Directed Topical Drug Delivery for Treatment for PASC Hyposmia | COMPLETED | PHASE2 | Duke University | Beclomethasone; Placebo; Microsponge |
| NCT ID | Title | Status | Phase | Sponsor | Intervention |
|---|---|---|---|---|---|
| NCT04141696 | A Proof-of-Concept Trial on the Effect of Ketamine on Fatigue | COMPLETED | PHASE1; PHASE2 | National Institute of Nursing Research (NINR) | Ketamine; Midazolam |
| NCT ID | Title | Status | Phase | Sponsor | Intervention |
|---|---|---|---|---|---|
| NCT04141696 | A Proof-of-Concept Trial on the Effect of Ketamine on Fatigue | COMPLETED | PHASE1; PHASE2 | National Institute of Nursing Research (NINR) | Ketamine; Midazolam |
| NCT ID | Title | Status | Phase | Sponsor | Intervention |
|---|---|---|---|---|---|
| NCT05121740 | Extension Study in a Cohort of Adult Patients With SARS-CoV-2 Infection Requiring Hospital Admission and Received Treatment With Plitidepsin in the APLICOV-PC Study | COMPLETED | PHASE1; PHASE2 | PharmaMar | Plitidepsin 1.5 mg / day; Plitidepsin 2.0 mg / day; Plitidepsin 2.5 mg / day |
| NCT ID | Title | Status | Phase | Sponsor | Intervention |
|---|---|---|---|---|---|
| NCT05592418 | A Randomized, Double Blind, Placebo Controlled Study to Evaluate the Efficacy and Safety of Ampligen® in Patients With Post-COVID Conditions | COMPLETED | PHASE2 | AIM ImmunoTech Inc. | Rintatolimod; Placebo / Normal Saline |
| NCT ID | Title | Status | Phase | Sponsor | Intervention |
|---|---|---|---|---|---|
| NCT05618587 | Effect of Low-dose Lithium Therapy on Long COVID Symptoms: a Randomized Controlled Trial. | COMPLETED | PHASE2 | State University of New York at Buffalo | Lithium; Placebo |
| NCT ID | Title | Status | Phase | Sponsor | Intervention |
|---|---|---|---|---|---|
| NCT05999435 | A DOUBLE-BLIND, RANDOMIZED, PLACEBO-CONTROLLED, ADAPTIVE PHASE 2/3 STUDY OF THE EFFICACY OF LAU-7b IN THE TREATMENT OF ADULTS WITH LONG COVID AND MODERATE TO SEVERE SYMPTOMS | COMPLETED | PHASE2; PHASE3 | Laurent Pharmaceuticals Inc. | LAU-7b for 3 cycles; LAU-7b for 1 cycle, then placebo; Placebo for 3 cycles |
| NCT ID | Title | Status | Phase | Sponsor | Intervention |
|---|---|---|---|---|---|
| NCT05047952 | Randomized, Double-Blinded, Placebo-Controlled Study Evaluating Vortioxetine for Cognitive Deficits in Persons With Post-COVID-19 Condition | COMPLETED | PHASE2 | Brain and Cognition Discovery Foundation | Vortioxetine; Placebo |
| NCT ID | Title | Status | Phase | Sponsor | Intervention |
|---|---|---|---|---|---|
| NCT05074888 | A Multicenter, Double-blind, Placebo-controlled, Parallel-group, Randomized Clinical Trial of Efficacy and Safety of Prospekta in the Treatment of Patients With Post-COVID-19 Asthe | COMPLETED | PHASE3 | Materia Medica Holding | Prospekta; Placebo |
| NCT ID | Title | Status | Phase | Sponsor | Intervention |
|---|---|---|---|---|---|
| NCT06253806 | Stellate Ganglion Block for the Treatment of COVID-19-Induced Parosmia: Double-Blinded, Placebo-Controlled Randomized Clinical Trial | COMPLETED | PHASE2 | Washington University School of Medicine | Stellate Ganglion Block; Placebo Sham Injection |
| NCT ID | Title | Status | Phase | Sponsor | Intervention |
|---|---|---|---|---|---|
| NCT04510194 | COVID-OUT: Early Outpatient Treatment for SARS-CoV-2 Infection (COVID-19) | COMPLETED | PHASE3 | University of Minnesota | Metformin; Placebo; Fluvoxamine; Ivermectin |
| NCT ID | Title | Status | Phase | Sponsor | Intervention |
|---|---|---|---|---|---|
| NCT06204432 | Efficacy of Adjunctive Sodium Citrate in Smell Retraining for People With Post-Acute Sequelae COVID-19 Olfactory Dysfunction | ACTIVE_NOT_RECRUITING | PHASE2 | University of North Carolina, Chapel Hill | Sodium Citrate; Normal Saline; Olfactory Training Kit - "The Olfactory Kit, by AdvancedRx" |
| NCT ID | Title | Status | Phase | Sponsor | Intervention |
|---|---|---|---|---|---|
| NCT05104749 | Homeopathic Treatment of Post-acute COVID-19 Syndrome- A Pilot Randomized Controlled Trial | COMPLETED | PHASE3 | Southwest College of Naturopathic Medicine | Homeopathic Medication; Placebo |
| NCT ID | Title | Status | Phase | Sponsor | Intervention |
|---|---|---|---|---|---|
| NCT03674541 | The Exercise Response to Pharmacologic Cholinergic Stimulation in Myalgic Encephalomyelitis / Chronic Fatigue Syndrome | COMPLETED | PHASE2 | Brigham and Women's Hospital | Pyridostigmine Bromide; Placebo |
| NCT ID | Title | Status | Phase | Sponsor | Intervention |
|---|---|---|---|---|---|
| NCT05204550 | A Randomised, Placebo-controlled Trial to Investigate the Efficacy of Intranasal Heparin Treatment to Reduce Transmission of SARS-CoV-2 Infection and COVID 19 Disease Among Househo | COMPLETED | PHASE2; PHASE3 | Murdoch Childrens Research Institute | unfractionated heparin; 0.9%sodium chloride |
| NCT ID | Title | Status | Phase | Sponsor | Intervention |
|---|---|---|---|---|---|
| NCT04313972 | IC PaIN Trial: Interstitial Cystitis Pain Improvement With Naltrexone, the Effect of Low Dose Naltrexone on Symptoms and Pain of Patients With Interstitial Cystitis/Painful Bladder | TERMINATED | PHASE4 | Endeavor Health | low-dose naltrexone; Placebo oral tablet |
| NCT ID | Title | Status | Phase | Sponsor | Intervention |
|---|---|---|---|---|---|
| NCT04977388 | Phase I/II Study of NORTHERA (DROXIDOPA) for Dysautonomia in Adult Survivors of Menkes Disease and Adults With Occipital Horn Syndrome: Double-blind Placebo-controlled Randomized C | COMPLETED | PHASE1; PHASE2 | Stephen G. Kaler, MD | Droxidopa; Placebo |
| NCT ID | Title | Status | Phase | Sponsor | Intervention |
|---|---|---|---|---|---|
| NCT05946551 | Feasibility Assessment of a Decentralized Platform Adaptive Double-Blind, Randomized Controlled Trial Investigating Repurposed Drugs in the Treatment of Post-Acute Sequelae of Coro | TERMINATED | PHASE3 | Emory University | Cetirizine; Famotidine; Cetirizine Placebo; Famotidine Placebo |
| NCT ID | Title | Status | Phase | Sponsor | Intervention |
|---|---|---|---|---|---|
| NCT05946551 | Feasibility Assessment of a Decentralized Platform Adaptive Double-Blind, Randomized Controlled Trial Investigating Repurposed Drugs in the Treatment of Post-Acute Sequelae of Coro | TERMINATED | PHASE3 | Emory University | Cetirizine; Famotidine; Cetirizine Placebo; Famotidine Placebo |
| NCT ID | Title | Status | Phase | Sponsor | Intervention |
|---|---|---|---|---|---|
| NCT05597722 | Randomized Study to Evaluate Strategies to Address Cognitive Fog in Long-COVID-19 Patients | TERMINATED | PHASE4 | Eva Szigethy | Digital cognitive behavioral intervention-RxWell; Amphetamine-Dextroamphetamine |
| NCT ID | Title | Status | Phase | Sponsor | Intervention |
|---|---|---|---|---|---|
| NCT05877508 | An Exploratory, Randomized, Double-Blind Placebo-Controlled Study to Assess the Safety of an Anti-SARS-CoV-2 Monoclonal Antibody and Response to Treatment in Individuals With Long | ACTIVE_NOT_RECRUITING | PHASE2 | Michael Peluso, MD | AER002; Placebo |
| NCT ID | Title | Status | Phase | Sponsor | Intervention |
|---|---|---|---|---|---|
| NCT04828135 | Characterizing the Long-Term Cardiopulmonary Effects of COVID-19 With Hyperpolarized Xenon and Cardiac MRI | COMPLETED | PHASE2 | Bastiaan Driehuys | Hyperpolarized 129Xenon gas |
| NCT ID | Title | Status | Phase | Sponsor | Intervention |
|---|---|---|---|---|---|
| NCT05472090 | A Phase 2, 14-week Double-Blind, Randomized, Multicenter, Placebo-Controlled Study to Evaluate the Efficacy and Safety of TNX-102 SL Taken Daily at Bedtime in Patients With Multisi | COMPLETED | PHASE2 | Tonix Pharmaceuticals, Inc. | TNX-102 SL; Placebo SL Tablet |
| NCT ID | Title | Status | Phase | Sponsor | Intervention |
|---|---|---|---|---|---|
| NCT05472090 | A Phase 2, 14-week Double-Blind, Randomized, Multicenter, Placebo-Controlled Study to Evaluate the Efficacy and Safety of TNX-102 SL Taken Daily at Bedtime in Patients With Multisi | COMPLETED | PHASE2 | Tonix Pharmaceuticals, Inc. | TNX-102 SL; Placebo SL Tablet |
| NCT ID | Title | Status | Phase | Sponsor | Intervention |
|---|---|---|---|---|---|
| NCT06316843 | A Randomized, Double-Blinded, Placebo-Controlled, Pilot Study of the Combination of Valacyclovir + Celecoxib (IMC-2) for the Treatment of Post-Acute Sequelae of SARS-CoV-2 Infectio | COMPLETED | PHASE2 | Bateman Horne Center | Valacyclovir celecoxib dose 1; Valacyclovir celecoxib dose 2; Placebo |
| NCT ID | Title | Status | Phase | Sponsor | Intervention |
|---|---|---|---|---|---|
| NCT06161688 | Placebo-Controlled, Randomized Trial of Ensitrelvir (S-217622) for Viral Persistence and Inflammation in People Experiencing Long COVID (PREVAIL-LC) | ACTIVE_NOT_RECRUITING | PHASE2 | Timothy Henrich | Ensitrelvir; Placebo |
| NCT ID | Title | Status | Phase | Sponsor | Intervention |
|---|---|---|---|---|---|
| NCT04871815 | Preliminary Examination of the Effects of Sodium Pyruvate Nasal Spray (N115) on Symptoms Associated With COVID19 Long Haulers. | COMPLETED | PHASE2; PHASE3 | Cellular Sciences, inc. | sodium pyruvate nasal spray |
| NCT ID | Title | Status | Phase | Sponsor | Intervention |
|---|---|---|---|---|---|
| NCT05513560 | REcovering From COVID-19 Lingering Symptoms Adaptive Integrative Medicine (RECLAIM) | COMPLETED | PHASE2; PHASE3 | University Health Network, Toronto | Ibudilast; Pentoxifylline; Placebo |
| NCT ID | Title | Status | Phase | Sponsor | Intervention |
|---|---|---|---|---|---|
| NCT06204432 | Efficacy of Adjunctive Sodium Citrate in Smell Retraining for People With Post-Acute Sequelae COVID-19 Olfactory Dysfunction | ACTIVE_NOT_RECRUITING | PHASE2 | University of North Carolina, Chapel Hill | Sodium Citrate; Normal Saline; Olfactory Training Kit - "The Olfactory Kit, by AdvancedRx" |
| NCT ID | Title | Status | Phase | Sponsor | Intervention |
|---|---|---|---|---|---|
| NCT04997395 | Safety and Tolerability of Full Spectrum Cannabidiol Dominant Medicinal Cannabis in Treating Symptoms Associated With Long COVID: A Feasibility Study | COMPLETED | PHASE2 | Bod Australia | MediCabilis Cannabis sativa 50 |
| NCT ID | Title | Status | Phase | Sponsor | Intervention |
|---|---|---|---|---|---|
| NCT06316843 | A Randomized, Double-Blinded, Placebo-Controlled, Pilot Study of the Combination of Valacyclovir + Celecoxib (IMC-2) for the Treatment of Post-Acute Sequelae of SARS-CoV-2 Infectio | COMPLETED | PHASE2 | Bateman Horne Center | Valacyclovir celecoxib dose 1; Valacyclovir celecoxib dose 2; Placebo |
| NCT ID | Title | Status | Phase | Sponsor | Intervention |
|---|---|---|---|---|---|
| NCT04988282 | Systemic Corticosteroids in Treatment of Post-COVID-19 Interstitial Lung Disease | COMPLETED | PHASE4 | Turkish Thoracic Society | Methylprednisolone Tablet |
| NCT ID | Title | Status | Phase | Sponsor | Intervention |
|---|---|---|---|---|---|
| NCT05638633 | Prednisolone and Vitamin B1, B6, and B12 in Patients With Post-COVID-19-Syndrome (PC19S) - a Randomized Controlled Trial in Primary Care | COMPLETED | PHASE3 | Wuerzburg University Hospital | Prednisolone 20 mg/ 5 mg; Vitamin B compound (100mg B1, 50 mg B6, 500 µg B12); Placebo for Vitamin B compound; Placebo for Prednisolon |
| NCT ID | Title | Status | Phase | Sponsor | Intervention |
|---|---|---|---|---|---|
| NCT05638633 | Prednisolone and Vitamin B1, B6, and B12 in Patients With Post-COVID-19-Syndrome (PC19S) - a Randomized Controlled Trial in Primary Care | COMPLETED | PHASE3 | Wuerzburg University Hospital | Prednisolone 20 mg/ 5 mg; Vitamin B compound (100mg B1, 50 mg B6, 500 µg B12); Placebo for Vitamin B compound; Placebo for Prednisolon |
| NCT ID | Title | Status | Phase | Sponsor | Intervention |
|---|---|---|---|---|---|
| NCT05638633 | Prednisolone and Vitamin B1, B6, and B12 in Patients With Post-COVID-19-Syndrome (PC19S) - a Randomized Controlled Trial in Primary Care | COMPLETED | PHASE3 | Wuerzburg University Hospital | Prednisolone 20 mg/ 5 mg; Vitamin B compound (100mg B1, 50 mg B6, 500 µg B12); Placebo for Vitamin B compound; Placebo for Prednisolon |
| NCT ID | Title | Status | Phase | Sponsor | Intervention |
|---|---|---|---|---|---|
| NCT04591210 | Evaluation of the Potential Benefit of Renin-angiotensin System Inhibitors (RASi, ACEi/ARB) in High-risk Patients With COVID-19. The COVID-RASi Trial | COMPLETED | PHASE3 | Ottawa Heart Institute Research Corporation | Angiotensin converting enzyme inhibitor; Angiotensin II Receptor Blockers |
| NCT ID | Title | Status | Phase | Sponsor | Intervention |
|---|---|---|---|---|---|
| NCT04591210 | Evaluation of the Potential Benefit of Renin-angiotensin System Inhibitors (RASi, ACEi/ARB) in High-risk Patients With COVID-19. The COVID-RASi Trial | COMPLETED | PHASE3 | Ottawa Heart Institute Research Corporation | Angiotensin converting enzyme inhibitor; Angiotensin II Receptor Blockers |
| NCT ID | Title | Status | Phase | Sponsor | Intervention |
|---|---|---|---|---|---|
| NCT05795816 | The Effectiveness of Testofen on Energy, Fatigue, Mental Acuity, and Other Quality of Life Symptoms Post COVID-19 Infection | COMPLETED | PHASE3 | RDC Clinical Pty Ltd | Testofen; Microcrystalline cellulose |
| NCT ID | Title | Status | Phase | Sponsor | Intervention |
|---|---|---|---|---|---|
| NCT05939622 | Prospective Randomized Double Blind Placebo Controlled Study of Efficacy of the Therapy With BRAINMAX® Using Functional Magnetic Resonance Imaging (fMRI) for the Treatment of Patie | COMPLETED | PHASE4 | Promomed, LLC | Structural and functional MRI; Ethyl methyl hydroxypyridine succinate + Meldonium; Placebo |
| NCT ID | Title | Status | Phase | Sponsor | Intervention |
|---|---|---|---|---|---|
| NCT05524532 | Effect of Immulina Supplements on Inflammatory Biomarkers Correlated With Clinical Symptoms in Patients With Long COVID (PASC) | COMPLETED | PHASE3 | University of Mississippi Medical Center | Immulina TM; Placebo |
| NCT ID | Title | Status | Phase | Sponsor | Intervention |
|---|---|---|---|---|---|
| NCT04830943 | The Effectiveness of Cerebrolycin, a Multi-modal Neurotrophic Factor, for Treatment of Post-covid-19 Persistent Olfactory, Gustatory and Trigeminal Chemosensory Dysfunctions: A Pil | COMPLETED | PHASE3 | Assiut University | Cerebrolysin |
| NCT ID | Title | Status | Phase | Sponsor | Intervention |
|---|---|---|---|---|---|
| NCT04622293 | A Double-Blind, Randomized, Placebo-Controlled, Single-Center, Flexible Titration Study Evaluating the Efficacy of Solriamfetol in Treating Fatigue and Cognitive Symptoms in Adults | COMPLETED | PHASE4 | Rochester Center for Behavioral Medicine | Solriamfetol Oral Tablet [Sunosi]; Placebo |
| NCT ID | Title | Status | Phase | Sponsor | Intervention |
|---|---|---|---|---|---|
| NCT06245642 | A Multi-center, Randomized, Double-blind, Positive Parallel Control Study of Compound Ciwujia Granules in the Treatment of Chronic Fatigue Syndrome (Spleen-kidney Deficiency Syndro | COMPLETED | PHASE4 | Heilongjiang Quanle Pharmaceutical Co., Ltd. | Compound Ciwujia Granules, Guipi Granules |
| NCT ID | Title | Status | Phase | Sponsor | Intervention |
|---|---|---|---|---|---|
| NCT05890534 | Pycnogenol® in People With Post-COVID-19 Condition: a Quadruple-blind, Randomized, Placebo-controlled Trial | COMPLETED | PHASE3 | University of Zurich | Pycnogenol®; Placebo |
| NCT ID | Title | Status | Phase | Sponsor | Intervention |
|---|---|---|---|---|---|
| NCT06383819 | Multicenter, Randomized, Double-blind, Placebo-controlled Parallel-group Study to Evaluate the Efficacy and Safety of Longidaza® for the Treatment of Patients With Residual Changes | COMPLETED | PHASE3 | NPO Petrovax | Longidaza®; Placebo |
| NCT ID | Title | Status | Phase | Sponsor | Intervention |
|---|---|---|---|---|---|
| NCT05121766 | Feasibility Pilot Clinical Trial of Omega-3 (EPA+DHA) Supplement vs. Placebo for Post-Acute Sequelae of Coronavirus-19 (COVID-19) Recovery Among Health Care Workers | TERMINATED | PHASE1 | Hackensack Meridian Health | Omega-3 (EPA+DHA); Placebo |
| NCT ID | Title | Status | Phase | Sponsor | Intervention |
|---|---|---|---|---|---|
| NCT05642923 | Post-COVID-19 Chronic Fatigue Syndrome | COMPLETED | PHASE4 | ClinAmygate | Synthetic Vitamin B1 |
| NCT ID | Title | Status | Phase | Sponsor | Intervention |
|---|---|---|---|---|---|
| NCT06128967 | An Adaptive, Randomized, doublE-blind, Placebo-controlled, Prospective, Pharmacological interVention Study In Participants With Long COVID-19 Syndrome: REVIVE-TOGETHER Trial | COMPLETED | PHASE3 | Cardresearch | Fluvoxamine Maleate 100 MG; Placebo; Metformin Extended Release Oral Tablet |
| NCT ID | Title | Status | Phase | Sponsor | Intervention |
|---|---|---|---|---|---|
| NCT06128967 | An Adaptive, Randomized, doublE-blind, Placebo-controlled, Prospective, Pharmacological interVention Study In Participants With Long COVID-19 Syndrome: REVIVE-TOGETHER Trial | COMPLETED | PHASE3 | Cardresearch | Fluvoxamine Maleate 100 MG; Placebo; Metformin Extended Release Oral Tablet |
| NCT ID | Title | Status | Phase | Sponsor | Intervention |
|---|---|---|---|---|---|
| NCT06437223 | A Phase 2 Study to Compare the Efficacy and Safety of Orally Administered Xiflam™ Therapy With Orally Administered Placebo in Patients With Ocular and Systemic Manifestations of Po | COMPLETED | PHASE2 | Inflammx Therapeutics Inc | Tonabersat; Placebo |
| NCT ID | Title | Status | Phase | Sponsor | Intervention |
|---|---|---|---|---|---|
| NCT04705831 | A Randomized, Double Blind, Placebo Controlled, Cross-Over, Proof-of-Concept Study to Evaluate the Benefit of RUCONEST (C1 Esterase Inhibitor [Recombinant]) in Improving Neurologic | COMPLETED | PHASE2 | IMMUNOe Research Centers | Ruconest |
| NCT ID | Title | Status | Phase | Sponsor | Intervention |
|---|---|---|---|---|---|
| NCT05096884 | Post-Acute Sequelae of Coronavirus-19 (COVID-19) With DysPnEA on ExertIon And Associated TaChycardia TrEatment Study | TERMINATED | EARLY_PHASE1 | Hackensack Meridian Health | Metoprolol Succinate |
| NCT ID | Title | Status | Phase | Sponsor | Intervention |
|---|---|---|---|---|---|
| NCT04604704 | Pilot Study Into Low Dose Naltrexone (LDN) and Nicotinamide Adenine Dinucleotide (NAD+) for Treatment of Patients With Post-COVID-19 Syndrome (Long-COVID19) | COMPLETED | PHASE2 | AgelessRx | Naltrexone; NAD+ |
| NCT ID | Title | Status | Phase | Sponsor | Intervention |
|---|---|---|---|---|---|
| NCT05513560 | REcovering From COVID-19 Lingering Symptoms Adaptive Integrative Medicine (RECLAIM) | COMPLETED | PHASE2; PHASE3 | University Health Network, Toronto | Ibudilast; Pentoxifylline; Placebo |
| NCT ID | Title | Status | Phase | Sponsor | Intervention |
|---|---|---|---|---|---|
| NCT05977166 | Influence of Hyperbaric Oxygen on Pulmonary Functions in Post Covid-19 Patients. | COMPLETED | nan | Cairo University | hyperbaric oxygen therapy; breathing exercise; medical treatment |
| NCT ID | Title | Status | Phase | Sponsor | Intervention |
|---|---|---|---|---|---|
| NCT05619653 | Randomised Placebo Controlled Clinical Trial of Efficacy of MYOcardial Protection in Patients With Postacute inFLAMmatory Cardiac involvEment Due to COVID-19 | ACTIVE_NOT_RECRUITING | PHASE3 | Valentina Puentmann | Prednisolone; Losartan |
| NCT ID | Title | Status | Phase | Sponsor | Intervention |
|---|---|---|---|---|---|
| NCT04948203 | SECOVID: A Multi-center, Randomized, Dose-ranging Parallel-group Trial Assessing the Efficacy of Sirolimus in Hospitalized Patients With COVID-19 Pneumonia for the Prevention of Po | ACTIVE_NOT_RECRUITING | PHASE2; PHASE3 | University of Chicago | Sirolimus |
| NCT ID | Title | Status | Phase | Sponsor | Intervention |
|---|---|---|---|---|---|
| NCT04961190 | A Comparison of Prolonged Exposure Therapy, Pharmacotherapy, and Their Combination for PTSD: What Works Best, and for Whom | ACTIVE_NOT_RECRUITING | PHASE4 | University of Pennsylvania | Prolonged Exposure Therapy; Pharmacotherapy with paroxetine or venlafaxine XR |
| NCT ID | Title | Status | Phase | Sponsor | Intervention |
|---|---|---|---|---|---|
| NCT06305780 | RECOVER-AUTONOMIC: A Platform Protocol for Evaluation of Interventions for Autonomic Dysfunction in Post-Acute Sequelae of SARS-CoV-2 Infection (PASC) | COMPLETED | PHASE2 | Kanecia Obie Zimmerman | IVIG + Coordinated Care; IVIG Placebo + Coordinated Care; Ivabradine + Coordinated Care; Ivabradine Placebo + Coordinated Care; IVIG + Usual Care; IVIG Placebo |
| NCT ID | Title | Status | Phase | Sponsor | Intervention |
|---|---|---|---|---|---|
| NCT05152849 | A Randomized, Double-Blind, Placebo-Controlled Pilot Study to Evaluate the Efficacy, Safety, and Tolerability of AXA1125 in Subjects With Fatigue-Predominant Post-Acute Sequelae of | COMPLETED | PHASE2 | Axcella Health, Inc | AXA1125; Placebo |
| NCT ID | Title | Status | Phase | Sponsor | Intervention |
|---|---|---|---|---|---|
| NCT05228899 | A Phase I/II Multicenter, Randomized, Double Blinded, Placebo Trial to Evaluate the Safety and Potential Efficacy of Zofin Infused Intravenous (IV) in Patients Experiencing Prolong | COMPLETED | PHASE1; PHASE2 | ZEO ScientifiX, Inc. | Zofin; Placebo |
| NCT ID | Title | Status | Phase | Sponsor | Intervention |
|---|---|---|---|---|---|
| NCT05911009 | A Prospective, Double-blind, Randomized, Parallel Group, Placebo Controlled, Multicentre, Phase II Study to Investigate the Efficacy, GPCR Autoantibody Neutralizing Effect, Safety, | COMPLETED | PHASE2 | Berlin Cures GmbH | BC 007 or matching placebo |
| NCT ID | Title | Status | Phase | Sponsor | Intervention |
|---|---|---|---|---|---|
| NCT05497089 | Temelimab as a Disease Modifying Therapy in Patients With Neurological, Neuropsychological, and Psychiatric (=Neuropsychiatric) Symptoms in Post-COVID 19 or Postacute Sequelae of C | COMPLETED | PHASE2 | GeNeuro SA | Temelimab 54mg/kg; Placebo |
| NCT ID | Title | Status | Phase | Sponsor | Intervention |
|---|---|---|---|---|---|
| NCT04944121 | A Phase 2, Double-blind, Placebo-controlled Study of RSLV-132 in Subjects With Post-acute COVID-19 (Long COVID) | COMPLETED | PHASE2 | Resolve Therapeutics | RSLV-132; Sodium Chloride 0.9% |
| NCT ID | Title | Status | Phase | Sponsor | Intervention |
|---|---|---|---|---|---|
| NCT04944121 | A Phase 2, Double-blind, Placebo-controlled Study of RSLV-132 in Subjects With Post-acute COVID-19 (Long COVID) | COMPLETED | PHASE2 | Resolve Therapeutics | RSLV-132; Sodium Chloride 0.9% |
| NCT ID | Title | Status | Phase | Sponsor | Intervention |
|---|---|---|---|---|---|
| NCT06223971 | A Phase l Study to Assess the Safety and Tolerability of PET Imaging With [11 C]CPPC [5-cyano-N-( 4-( 4-[l l CJ me1hylpiperazin-l-yl)-2-(Piperidin-l-yl)Phenyl)Furan-2-carboxamide] | COMPLETED | EARLY_PHASE1 | Johns Hopkins University | [11C]CPPC Injection; [11C]CPPC Injection |
| NCT ID | Title | Status | Phase | Sponsor | Intervention |
|---|---|---|---|---|---|
| NCT05638620 | Evaluating the Effectiveness of Dual Sympathetic Blocks for Patients Experiencing Sympathetically-Mediated Symptoms From Post-Acute Sequelae of SARS-CoV-2 (PASC) | COMPLETED | PHASE1 | Jonathann Kuo, MD | stellate ganglion block with 0.5% bupivacaine |
| NCT ID | Title | Status | Phase | Sponsor | Intervention |
|---|---|---|---|---|---|
| NCT06596161 | Effect or Iron Therapy on Fatigue Symptoms in Non-anemic Iron Deficient Women of Reproductive Age | COMPLETED | nan | Central Park Medical College | Iron sucrose; Placebo |
| NCT ID | Title | Status | Phase | Sponsor | Intervention |
|---|---|---|---|---|---|
| NCT06721949 | Taurine Supplementation as a Novel Therapeutic Approach for Neurocognitive Symptoms in Long COVID | RECRUITING | PHASE2; PHASE3 | University of Alberta | Taurine; Placebo |
| NCT ID | Title | Status | Phase | Sponsor | Intervention |
|---|---|---|---|---|---|
| NCT04439825 | Randomized Controlled Single Blind Cross Over Trial Evaluating the Impact of Botox Treatment Into the Upper One Third of the Face an Area on Mood and Self -Appearance Satisfaction | COMPLETED | PHASE1 | DeNova Research | Botulinum Neurotoxin; Placebo |
| NCT ID | Title | Status | Phase | Sponsor | Intervention |
|---|---|---|---|---|---|
| NCT06419712 | Effect of Vitamin D Supplementation on Glutathione Peroxidase (GPx) Activity, Interleukin-6 (IL-6) Levels and Clinical Outcomes in Post-COVID-19 Patients | COMPLETED | nan | Escuela Militar de Graduados de Sanidad, SEDENA | vitamin D (cholecalciferol) supplementation |
| NCT ID | Title | Status | Phase | Sponsor | Intervention |
|---|---|---|---|---|---|
| NCT04308278 | Randomized, Placebo-controlled, Double Blind Study to Evaluate the Efficacy of 2LEBV® and 2LXFS® on Asthenia in Patients With an Epstein-Barr Virus Infection. | RECRUITING | PHASE4 | Labo'Life | 2LEBV® / 2LXFS®; Placebo |
| NCT ID | Title | Status | Phase | Sponsor | Intervention |
|---|---|---|---|---|---|
| NCT05901337 | Influence of Cupping Therapy on Immune System in Post Covid- 19 Patients | COMPLETED | nan | Cairo University | Cupping therapy with convential medical treatment; Convential medical treatment |
| NCT ID | Title | Status | Phase | Sponsor | Intervention |
|---|---|---|---|---|---|
| NCT06694740 | Effect of Interferon Gamma as a Treatment for Post-aggressive Immunosuppression in Intensive Care Units, a Randomized Bayesian Double-blind Controlled Trial Versus Placebo | RECRUITING | PHASE2; PHASE3 | Assistance Publique - Hôpitaux de Paris | Interferon Gamma 1-b; Placebo |
| NCT ID | Title | Status | Phase | Sponsor | Intervention |
|---|---|---|---|---|---|
| NCT07280572 | RECLAIM: an Adaptive Platform Trial for the Evaluation of Treatments for Post-Acute Sequelae of SARS-CoV-2 Infection (PASC) | ENROLLING_BY_INVITATION | PHASE3 | Janneke van de Wijgert | Metformin; colchicine |
| NCT ID | Title | Status | Phase | Sponsor | Intervention |
|---|---|---|---|---|---|
| NCT05697640 | A Parallel-group Treatment, Phase 2a, Double-blind, Placebo-controlled 2-arm Study to Show Improvement of Physical Function in SF-36 (SF-36-PF) in Participants Treated With Vericig | ACTIVE_NOT_RECRUITING | PHASE2 | Charite University, Berlin, Germany | Vericiguat Oral Tablet |
| NCT ID | Title | Status | Phase | Sponsor | Intervention |
|---|---|---|---|---|---|
| NCT05204550 | A Randomised, Placebo-controlled Trial to Investigate the Efficacy of Intranasal Heparin Treatment to Reduce Transmission of SARS-CoV-2 Infection and COVID 19 Disease Among Househo | COMPLETED | PHASE2; PHASE3 | Murdoch Childrens Research Institute | unfractionated heparin; 0.9%sodium chloride |
Each bar shows how many Post-COVID trials in this corpus test a given drug or intervention class. The list was compiled from expert knowledge of the Post-COVID treatment landscape — covering antivirals, immunomodulators, anticoagulants, autonomic agents, and repurposed drugs — then matched systematically against trial records from CT.gov (746 intervention trials total). This gives an at-a-glance picture of where research effort is concentrated, which therapeutic hypotheses are being actively tested, and where coverage is thin. Trials can match more than one class.
| NCT ID | Title | Status | Phase | Sponsor | Intervention |
|---|---|---|---|---|---|
| NCT05104749 | Homeopathic Treatment of Post-acute COVID-19 Syndrome- A Pilot Randomized Controlled Trial | COMPLETED | PHASE3 | Southwest College of Naturopathic Medicine | Homeopathic Medication; Placebo |
| NCT05204550 | A Randomised, Placebo-controlled Trial to Investigate the Efficacy of Intranasal Heparin Treatment to Reduce Transmission of SARS-CoV-2 Infection and COVID 19 Disease Among Househo | COMPLETED | PHASE2; PHASE3 | Murdoch Childrens Research Institute | unfractionated heparin; 0.9%sodium chloride |
| NCT05524532 | Effect of Immulina Supplements on Inflammatory Biomarkers Correlated With Clinical Symptoms in Patients With Long COVID (PASC) | COMPLETED | PHASE3 | University of Mississippi Medical Center | Immulina TM; Placebo |
| NCT05121766 | Feasibility Pilot Clinical Trial of Omega-3 (EPA+DHA) Supplement vs. Placebo for Post-Acute Sequelae of Coronavirus-19 (COVID-19) Recovery Among Health Care Workers | TERMINATED | PHASE1 | Hackensack Meridian Health | Omega-3 (EPA+DHA); Placebo |
| NCT05445674 | Plasma Exchange Therapy for Post- COVID-19 Condition: A Pilot, Randomized Double-Blind Study | COMPLETED | PHASE2 | Fundación FLS de Lucha Contra el Sida, las Enfermedades Infecciosas y la Promoción de la Salud y la Ciencia | Plasma Exchange Procedure; Sham Plasma Exchange Procedure |
| NCT05758480 | Characterization of the Immunometabolic Signature in Long COVID-19. | COMPLETED | nan | University Hospital, Angers | Blood sample (at inclusion and 6 months later); Patient questionnaires (at inclusion and 6 months later) |
| NCT05664711 | Effect of Stellate Ganglion Block on ME/CFS Symptoms and Metabolites | COMPLETED | PHASE1 | Neuroversion, Inc. | Bupivacaine Injection |
| NCT07238465 | Dysautonomia InVestigation in Individuals With Down SyndromE: DIVE Study | RECRUITING | PHASE3 | University of Colorado, Denver | Fear Response; Cold Stress; Pain Response; Caffeine; 12-Hour Fast; Maximal Dynamic Exercise |
| NCT06695910 | Modulation of the Brain Fog Scale by Eicosapentaenoic Acid Monoglycerides (MAG-EPA) in Volunteers Who Reported Suffering From Haze or Mental Fatigue on a Regular Basis. Exploratory | RECRUITING | PHASE4 | Samuel Fortin | Monoglyceride Eicosapentaenoic acid (omega-3); Sunflower Oil |
| NCT06217614 | Beneficial Effects of Specific Natural Products on Management of Xerostomia: A Randomized Controlled Clinical Trial | COMPLETED | nan | British University In Egypt | (Manuka honey-green tea) |
| NCT07128082 | The Long COVID Treatment Trial | ACTIVE_NOT_RECRUITING | PHASE2 | Scripps Translational Science Institute | Tirzepatide; Placebo |
| NCT07398508 | Phase I/II Study of NORTHERA (DROXIDOPA) for Dysautonomia in Pediatric Survivors of Menkes Disease: Double-blind Placebo-controlled Randomized Crossover Clinical Trial. | RECRUITING | PHASE1; PHASE2 | Stephen G. Kaler | Droxidopa Oral Product; Placebo Control |
| NCT07374562 | Effect of Stellate Ganglion Block Treatment on Long COVID Symptoms: A Single-Blind, Single-Center Randomized Controlled Trial (STAR-CO) | RECRUITING | nan | Centre intégré universitaire de santé et de services sociaux de la Mauricie-et-du-Centre-du-Québec | Stellate Ganglion Block (Bupivacaine); placebo saline injection |
| NCT06522750 | Pilot Study on the Feasibility of an RCT: Evaluating Periodic Fasting as a Treatment Strategy for Long Covid in Adults | RECRUITING | nan | University of Luxembourg | 7-day ambulatory caloric restriction intervention using the Buchinger-Wilhelmi method |
| NCT07320937 | Effects of Yiqi Fuyuan Paste Formula in Chronic Fatigue Syndrome: A Randomized Double-Blind Controlled Clinical Trial. | ENROLLING_BY_INVITATION | nan | ShuGuang Hospital | "Yiqi Fuyuan Paste Formula" test group; Placebo(a look-alike substance that contains no drug) |
| NCT06095297 | Technique to Enable Return-to-Work by Employees With Long COVID Brain Fog | RECRUITING | nan | University of Alabama at Birmingham | Processing Speed Training; In-lab Instrumental Activities of Daily Living Training; In-lab Brain Health Training; Transfer Package; Follow Up Phone Calls; Vocat |
| NCT07009691 | Heart Rate Variability as an Autonomic Marker of Improvement in ME/CFS in a Hydrogen Water Treatment Study | RECRUITING | nan | Stony Brook University | Hydrogen water which is prepared from an OTC supplement. |
| NCT06544395 | Efficacy of Non-invasive Neuromodulation Treatments for Post-COVID-19 Sequelae in Patients With Musculoskeletal, Respiratory and Neurological Conditions Due to Impaired Taste and S | NOT_YET_RECRUITING | nan | Clinica Gema Leon | Non invasive neuromodulation therapy; Manual therapy; Placebo with non invasive neuromodulation |
| NCT04846010 | Treating Sequalae Caused by Post-acute Sequelae of SARS (Severe Acute Respiratory Syndrome)-CoV-2 Infection | UNKNOWN | PHASE1; PHASE2 | All Natural Medicine Clinic, LLC | PurWet; FurFat; PurApo; PurPhl; PurClo; PurInf; Smoliv |
| NCT06765421 | Optimising General Practice Long COVID Care - Feasibility Trial of a Pilot Educational Intervention. | NOT_YET_RECRUITING | nan | University College Dublin | Intervention Group |
| NCT05234281 | Concentrated Cross-disciplinary Group Intervention for Common Health Complaints (Mixed Anxiety Depression, Diabetes Mellitus Type 2, Low Back Pain, Chronic Obstructive Pulmonary Di | UNKNOWN | nan | Helse i Hardanger | Interdisciplincary concentrated group rehabilitation |
| NCT05808400 | Clinical Study of the Safety and Efficacy of Umbilical Cord Mesenchymal Stem Cell Exosomes in Treating Chronic Cough After COVID-19 Infection | UNKNOWN | EARLY_PHASE1 | Huazhong University of Science and Technology | MSC-derived exosomes |
| NCT06018649 | The Effectiveness and Safety of Using Lithuania's Natural Resources to Improve Stress-related Mental and Physical Health | UNKNOWN | nan | Klaipėda University | Balneotherapy plus complex; Combined nature resources treatment; Nature therapy procedure |
| NCT ID | Title | Status | Phase | Sponsor | Intervention |
|---|---|---|---|---|---|
| NCT04871815 | Preliminary Examination of the Effects of Sodium Pyruvate Nasal Spray (N115) on Symptoms Associated With COVID19 Long Haulers. | COMPLETED | PHASE2; PHASE3 | Cellular Sciences, inc. | sodium pyruvate nasal spray |
| NCT05970731 | Directed Topical Drug Delivery for Treatment for PASC Hyposmia | COMPLETED | PHASE2 | Duke University | Beclomethasone; Placebo; Microsponge |
| NCT03356821 | Adult Mesenchymal Stromal Cells to Regenerate the Neonatal Brain: the PASSIoN Trial (Perinatal Arterial Stroke Treated With Stromal Cells IntraNasally) | COMPLETED | PHASE1; PHASE2 | UMC Utrecht | Mesenchymal Stem Cells |
| NCT05204550 | A Randomised, Placebo-controlled Trial to Investigate the Efficacy of Intranasal Heparin Treatment to Reduce Transmission of SARS-CoV-2 Infection and COVID 19 Disease Among Househo | COMPLETED | PHASE2; PHASE3 | Murdoch Childrens Research Institute | unfractionated heparin; 0.9%sodium chloride |
| NCT06974058 | Evaluation of a Quercetin/Curcumin-Based Supplement for Mild to Moderate Long COVID-19 Symptoms: A Pragmatic, Interventional Clinical Study. | COMPLETED | nan | Liaquat University of Medical & Health Sciences | Nasafytol® (Quercetin/Curcumin Supplement) |
| NCT05857124 | A Pilot Study Evaluating the Efficacy of the Vielight Neuro RX Gamma in the Treatment of Post COVID-19 Cognitive Impairment | COMPLETED | PHASE1 | Vielight Inc. | Vielight Neuro RX Gamma active device; Vielight Neuro RX Gamma sham device |
| NCT05855369 | A Randomized Controlled Trial of Smell Training and Trigeminal Nerve Stimulation in the Treatment of COVID-related Persistent Smell Loss | RECRUITING | PHASE2; PHASE3 | Medical University of South Carolina | Trigeminal Nerve Stimulation (TNS); Active Smell Training (ST); Placebo Smell Training (PBO) |
| NCT06204432 | Efficacy of Adjunctive Sodium Citrate in Smell Retraining for People With Post-Acute Sequelae COVID-19 Olfactory Dysfunction | ACTIVE_NOT_RECRUITING | PHASE2 | University of North Carolina, Chapel Hill | Sodium Citrate; Normal Saline; Olfactory Training Kit - "The Olfactory Kit, by AdvancedRx" |
| NCT04950725 | Covid-19 Virtual Recovery Study | COMPLETED | nan | Mayo Clinic | Strength RMT; Strength RMT and nasal breathing; Endurance RMT; Endurance RMT and nasal breathing; Low dose RMT |
| NCT06170645 | Transcutaneous Vagus Nerve Stimulation as a Complementary Therapy to Exercise in Chronic Fatigue: Single-center, Controlled, Randomized, Blinded Study | RECRUITING | nan | Centre Hospitalier Universitaire de Saint Etienne | APA program; Active transcutaneous VNS; Sham transcutaneous VNS |
| NCT04374474 | Olfactory Retraining Therapy and Budesonide Nasal Rinse for Anosmia Treatment in Patients Post-CoVID 19. A Randomized Controlled Trial | WITHDRAWN | PHASE4 | London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's | Olfactory retraining; corticosteroid nasal irrigation; smell household Items; Nasal Irrigation |
| NCT05890599 | Randomized Multicenter Clinical Trial: Yoga Versus Health Education for the Treatment of Persistent Fatigue in Patients With Post COVID-19 Syndrome | RECRUITING | nan | University Hospital Tuebingen | Yoga Therapy; Health Education |
| NCT06379672 | An Investigation of the Efficacy of Resonance Breathing Training in the Rehabilitation of Patients with Long Covid-related Myocardial Injury | NOT_YET_RECRUITING | nan | Chengdu Sport University | Resonance breathing |
| NCT04422275 | Coronavirus Smell Therapy for Anosmia Recovery | WITHDRAWN | PHASE2 | Washington University School of Medicine | Budesonide; High-Concentration Essential Oil; Placebo; Low-Concentration Essential Oil |
| NCT05269017 | The Potential Therapeutic Effect of Vitamin D Nasal Drops in the Treatment of Post COVID-19 Parosmia | UNKNOWN | PHASE2 | Menoufia University | Vitamin D3; Budesonide nasal spray |
| NCT05269030 | The Potential Therapeutic Effect of Ivermectin Nasal Drops in the Treatment of Post COVID-19 Parosmia | UNKNOWN | PHASE2 | Menoufia University | Ivermectin Topical; Budesonide Nasal |
| NCT04898205 | Cardiopulmonary Rehabilitation in COVID-19 Longhaulers | UNKNOWN | nan | Noah Greenspan | Treadmill Exercise; Concentrated Oxygen; Concentrated Air |
| NCT05749757 | The Efficacy and Safety of Acupuncture for Post COVID-19 Fatigue: a Randomized Controlled Trial | UNKNOWN | nan | Guang'anmen Hospital of China Academy of Chinese Medical Sciences | Acupuncture; Sham Acupuncture |
| NCT ID | Title | Status | Phase | Sponsor | Intervention |
|---|---|---|---|---|---|
| NCT05576662 | Selective Trial Of Paxlovid for PASC (STOP-PASC): Randomized Double-Blind Placebo-Controlled Pilot Trial of Paxlovid for the Treatment of PASC | COMPLETED | PHASE2 | Stanford University | Nirmatrelvir; Placebo; Ritonavir |
| NCT05965726 | RECOVER-VITAL: A Platform Protocol for Evaluation of Interventions for Viral Persistence, Viral Reactivation, and Immune Dysregulation in Post-Acute Sequelae of SARS-CoV-2 Infectio | COMPLETED | PHASE2 | Kanecia Obie Zimmerman | Paxlovid; Ritonavir; Nirmatrelvir-matching placebo |
| NCT05595369 | RECOVER-VITAL: A Platform Protocol for Evaluation of Interventions for Viral Persistence, Viral Reactivation, and Immune Dysregulation in Post-Acute Sequelae of SARS-CoV-2 Infectio | COMPLETED | PHASE2 | Kanecia Obie Zimmerman | Experimental: Paxlovid 25 day dosing; Experimental: Paxlovid 15 day dosing; Placebo Comparator: Control |
| NCT05668091 | An Interventional Decentralized Phase 2, Randomized, Double-Blind, 2-Arm Study to Investigate the Efficacy and Safety of Orally Administered Nirmatrelvir/Ritonavir Compared with Pl | COMPLETED | PHASE2 | Harlan M Krumholz | Nirmatrelvir; Ritonavir; Placebo |
| NCT05823896 | An Interventional, Double-Blinded, 2-Arm Study to Investigate the Efficacy of Orally Administered Nirmatrelvir/Ritonavir Compared with Placebo/Ritonavir in Non-hospitalized Adult P | COMPLETED | PHASE2 | Karolinska Institutet | Nirmatrelvir/ritonavir; Placebo/ritonavir |
| NCT05852873 | PAxlovid loNg cOvid-19 pRevention triAl With recruitMent In the Community in Norway | ACTIVE_NOT_RECRUITING | PHASE3 | Haukeland University Hospital | Nirmatrelvir/ritonavir; Placebo |
| NCT06441955 | Covid-19 Long Haul Syndrome: Undiagnosed Disorder Post Covid-19 Alternative Treatment Study. | RECRUITING | PHASE4 | Well- Konnect Healthcare Services and Research Firm | Ritonavir-Boosted Nirmatrelvir (Paxlovid); Physiological Evaluation; Moderna COVID-19 Vaccine; Biopsychological; Behavioral (e.g., Psychotherapy, Lifestyle Coun |
| NCT06792214 | Antiviral Strategies in the Prevention of Long-term Cardiovascular Outcomes Following COVID-19: The paxloviD/Remdesivir Effectiveness For the prEvention of loNg coviD (DEFEND) Clin | RECRUITING | PHASE4 | Mount Sinai Hospital, Canada | Nirmatrelvir/ritonavir; Remdesivir |
| NCT07597902 | SARS-CoV-2 and Herpesvirus Inhibition for Ending Long COVID Dysfunction (SHIELD) | NOT_YET_RECRUITING | PHASE2 | Icahn School of Medicine at Mount Sinai | Valacyclovir; Celecoxib; Paxlovid; Placebo |
| NCT ID | Title | Status | Phase | Sponsor | Intervention |
|---|---|---|---|---|---|
| NCT04988282 | Systemic Corticosteroids in Treatment of Post-COVID-19 Interstitial Lung Disease | COMPLETED | PHASE4 | Turkish Thoracic Society | Methylprednisolone Tablet |
| NCT05638633 | Prednisolone and Vitamin B1, B6, and B12 in Patients With Post-COVID-19-Syndrome (PC19S) - a Randomized Controlled Trial in Primary Care | COMPLETED | PHASE3 | Wuerzburg University Hospital | Prednisolone 20 mg/ 5 mg; Vitamin B compound (100mg B1, 50 mg B6, 500 µg B12); Placebo for Vitamin B compound; Placebo for Prednisolon |
| NCT05619653 | Randomised Placebo Controlled Clinical Trial of Efficacy of MYOcardial Protection in Patients With Postacute inFLAMmatory Cardiac involvEment Due to COVID-19 | ACTIVE_NOT_RECRUITING | PHASE3 | Valentina Puentmann | Prednisolone; Losartan |
| NCT04657484 | Comparison of the Efficacy and Safety of Two Corticosteroid Regimens in the Treatment of Diffuse Lung Disease After Coronavirus Disease 2019 (COVID-19) Pneumonia | COMPLETED | nan | Post Graduate Institute of Medical Education and Research, Chandigarh | Medium dose prednisolone; Low dose prednisolone |
| NCT07380152 | Corticosteroid Treatment for Post-COVID-19 Persistent Interstitial Lung Disease | COMPLETED | PHASE1 | University of Sao Paulo | Prednisolone |
| NCT07567274 | Single-Arm Pilot Study of Compounded DMSO-Based Dual-Route Therapy for Refractory Subjective Tinnitus in PASC and Post-COVID-19 Vaccine Injury | ENROLLING_BY_INVITATION | PHASE2 | Leading Edge Clinic | DMSO-based otic solution with betahistine, dexamethasone, and lidocaine; DMSO-based transdermal cream with levocarnitine and N-acetylcysteine |
| NCT04374474 | Olfactory Retraining Therapy and Budesonide Nasal Rinse for Anosmia Treatment in Patients Post-CoVID 19. A Randomized Controlled Trial | WITHDRAWN | PHASE4 | London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's | Olfactory retraining; corticosteroid nasal irrigation; smell household Items; Nasal Irrigation |
| NCT05986422 | Phase 2a, Double-blind, Randomized, Placebo-controlled Trial of Methylprednisolone Versus Placebo in Patients With Cognitive Deficits in Post-COVID-19 Syndrome (PCS) | TERMINATED | PHASE2 | Charite University, Berlin, Germany | Methylprednisolone |
| NCT06597682 | A Randomized Controlled Basket Study for Evaluating Immunomodulatory Interventions in Post-Acute Sequelae of SARS-CoV-2 InfEction (RISE) | NOT_YET_RECRUITING | nan | Huashan Hospital | Prednisone; Budesonide/Formoterol; Vitamin C combined with Coenzyme Q10 oral treatment; Montelukast tablets oral treatment |
| NCT ID | Title | Status | Phase | Sponsor | Intervention |
|---|---|---|---|---|---|
| NCT05576662 | Selective Trial Of Paxlovid for PASC (STOP-PASC): Randomized Double-Blind Placebo-Controlled Pilot Trial of Paxlovid for the Treatment of PASC | COMPLETED | PHASE2 | Stanford University | Nirmatrelvir; Placebo; Ritonavir |
| NCT05965726 | RECOVER-VITAL: A Platform Protocol for Evaluation of Interventions for Viral Persistence, Viral Reactivation, and Immune Dysregulation in Post-Acute Sequelae of SARS-CoV-2 Infectio | COMPLETED | PHASE2 | Kanecia Obie Zimmerman | Paxlovid; Ritonavir; Nirmatrelvir-matching placebo |
| NCT05595369 | RECOVER-VITAL: A Platform Protocol for Evaluation of Interventions for Viral Persistence, Viral Reactivation, and Immune Dysregulation in Post-Acute Sequelae of SARS-CoV-2 Infectio | COMPLETED | PHASE2 | Kanecia Obie Zimmerman | Experimental: Paxlovid 25 day dosing; Experimental: Paxlovid 15 day dosing; Placebo Comparator: Control |
| NCT05668091 | An Interventional Decentralized Phase 2, Randomized, Double-Blind, 2-Arm Study to Investigate the Efficacy and Safety of Orally Administered Nirmatrelvir/Ritonavir Compared with Pl | COMPLETED | PHASE2 | Harlan M Krumholz | Nirmatrelvir; Ritonavir; Placebo |
| NCT05823896 | An Interventional, Double-Blinded, 2-Arm Study to Investigate the Efficacy of Orally Administered Nirmatrelvir/Ritonavir Compared with Placebo/Ritonavir in Non-hospitalized Adult P | COMPLETED | PHASE2 | Karolinska Institutet | Nirmatrelvir/ritonavir; Placebo/ritonavir |
| NCT05852873 | PAxlovid loNg cOvid-19 pRevention triAl With recruitMent In the Community in Norway | ACTIVE_NOT_RECRUITING | PHASE3 | Haukeland University Hospital | Nirmatrelvir/ritonavir; Placebo |
| NCT06441955 | Covid-19 Long Haul Syndrome: Undiagnosed Disorder Post Covid-19 Alternative Treatment Study. | RECRUITING | PHASE4 | Well- Konnect Healthcare Services and Research Firm | Ritonavir-Boosted Nirmatrelvir (Paxlovid); Physiological Evaluation; Moderna COVID-19 Vaccine; Biopsychological; Behavioral (e.g., Psychotherapy, Lifestyle Coun |
| NCT06792214 | Antiviral Strategies in the Prevention of Long-term Cardiovascular Outcomes Following COVID-19: The paxloviD/Remdesivir Effectiveness For the prEvention of loNg coviD (DEFEND) Clin | RECRUITING | PHASE4 | Mount Sinai Hospital, Canada | Nirmatrelvir/ritonavir; Remdesivir |
| NCT07597902 | SARS-CoV-2 and Herpesvirus Inhibition for Ending Long COVID Dysfunction (SHIELD) | NOT_YET_RECRUITING | PHASE2 | Icahn School of Medicine at Mount Sinai | Valacyclovir; Celecoxib; Paxlovid; Placebo |
| NCT ID | Title | Status | Phase | Sponsor | Intervention |
|---|---|---|---|---|---|
| NCT06419712 | Effect of Vitamin D Supplementation on Glutathione Peroxidase (GPx) Activity, Interleukin-6 (IL-6) Levels and Clinical Outcomes in Post-COVID-19 Patients | COMPLETED | nan | Escuela Militar de Graduados de Sanidad, SEDENA | vitamin D (cholecalciferol) supplementation |
| NCT05901337 | Influence of Cupping Therapy on Immune System in Post Covid- 19 Patients | COMPLETED | nan | Cairo University | Cupping therapy with convential medical treatment; Convential medical treatment |
| NCT04751669 | Efficacy of Micronutrient Dietary Supplementation in Reducing Hospital Admissions for COVID-19: A Double-blind, Placebo-controlled, Randomized Clinical Trial | COMPLETED | nan | Fundació Institut Germans Trias i Pujol | Vitamin and trace elements; Placebo |
| NCT05977166 | Influence of Hyperbaric Oxygen on Pulmonary Functions in Post Covid-19 Patients. | COMPLETED | nan | Cairo University | hyperbaric oxygen therapy; breathing exercise; medical treatment |
| NCT05630339 | Efficacy and Security of the Magnesium and Vitamin D Combination as Adjuvant Treatment of Post-COVID Syndrome. A Randomised Double-blind Clinical Trial | COMPLETED | nan | Coordinación de Investigación en Salud, Mexico | Magnesium chloride; Vitamin D; Inert placebo |
| NCT05356936 | Pilot Study of Vitamin K2 (MK-7) and Vitamin D3 Supplementation and the Effects on PASC Symptomatology and Inflammatory Biomarkers | COMPLETED | nan | University Hospitals Cleveland Medical Center | Vitamin K2 (MK-7); Vitamin D3 |
| NCT05633472 | The Roles of Vitamin D and Microbiome in Children With Post-acute COVID-19 Syndromes (PACS) and Long COVID | COMPLETED | nan | China Medical University Hospital | Vitamin D; Placebo |
| NCT05269017 | The Potential Therapeutic Effect of Vitamin D Nasal Drops in the Treatment of Post COVID-19 Parosmia | UNKNOWN | PHASE2 | Menoufia University | Vitamin D3; Budesonide nasal spray |
| NCT ID | Title | Status | Phase | Sponsor | Intervention |
|---|---|---|---|---|---|
| NCT04510194 | COVID-OUT: Early Outpatient Treatment for SARS-CoV-2 Infection (COVID-19) | COMPLETED | PHASE3 | University of Minnesota | Metformin; Placebo; Fluvoxamine; Ivermectin |
| NCT05047952 | Randomized, Double-Blinded, Placebo-Controlled Study Evaluating Vortioxetine for Cognitive Deficits in Persons With Post-COVID-19 Condition | COMPLETED | PHASE2 | Brain and Cognition Discovery Foundation | Vortioxetine; Placebo |
| NCT05874037 | Fluvoxamine as a Treatment for Long COVID-19: A Randomized Placebo Controlled Trial | COMPLETED | PHASE2; PHASE3 | Washington University School of Medicine | Fluvoxamine |
| NCT06128967 | An Adaptive, Randomized, doublE-blind, Placebo-controlled, Prospective, Pharmacological interVention Study In Participants With Long COVID-19 Syndrome: REVIVE-TOGETHER Trial | COMPLETED | PHASE3 | Cardresearch | Fluvoxamine Maleate 100 MG; Placebo; Metformin Extended Release Oral Tablet |
| NCT04961190 | A Comparison of Prolonged Exposure Therapy, Pharmacotherapy, and Their Combination for PTSD: What Works Best, and for Whom | ACTIVE_NOT_RECRUITING | PHASE4 | University of Pennsylvania | Prolonged Exposure Therapy; Pharmacotherapy with paroxetine or venlafaxine XR |
| NCT07359482 | sElective Serotonin reuPtake inhibitoRs In posT-covid: ESPRIT | NOT_YET_RECRUITING | PHASE3 | Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) | Fluvoxamine; Placebo |
| NCT ID | Title | Status | Phase | Sponsor | Intervention |
|---|---|---|---|---|---|
| NCT04313972 | IC PaIN Trial: Interstitial Cystitis Pain Improvement With Naltrexone, the Effect of Low Dose Naltrexone on Symptoms and Pain of Patients With Interstitial Cystitis/Painful Bladder | TERMINATED | PHASE4 | Endeavor Health | low-dose naltrexone; Placebo oral tablet |
| NCT04604704 | Pilot Study Into Low Dose Naltrexone (LDN) and Nicotinamide Adenine Dinucleotide (NAD+) for Treatment of Patients With Post-COVID-19 Syndrome (Long-COVID19) | COMPLETED | PHASE2 | AgelessRx | Naltrexone; NAD+ |
| NCT05430152 | A Double Blind Randomized Trial of Low-dose Naltrexone for Post-COVID Fatigue Syndrome | COMPLETED | PHASE2 | Luis Nacul | Low-Dose Naltrexone; Placebo |
| NCT05363514 | A Pilot Study of Low Dose Naltrexone Use in Patients With Postural Orthostatic Tachycardia Syndrome | NOT_YET_RECRUITING | PHASE4 | University of Calgary | Low Dose Naltrexone; Microcrystalline cellulose |
| NCT06366724 | LIFT: Life Improvement Trial | RECRUITING | PHASE2 | Brigham and Women's Hospital | Pyridostigmine; Low-Dose Naltrexone; Placebo |
| NCT07285473 | Low-dose Naltrexone (LDN) for the Treatment of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS): Dose-Finding | NOT_YET_RECRUITING | PHASE2 | University of Alabama at Birmingham | Low-Dose Naltrexone, 1.5mg; Low-Dose Naltrexone, 3.0mg; Low-Dose Naltrexone, 4.5mg; Low-Dose Naltrexone, 6.0mg |
| NCT ID | Title | Status | Phase | Sponsor | Intervention |
|---|---|---|---|---|---|
| NCT06305780 | RECOVER-AUTONOMIC: A Platform Protocol for Evaluation of Interventions for Autonomic Dysfunction in Post-Acute Sequelae of SARS-CoV-2 Infection (PASC) | COMPLETED | PHASE2 | Kanecia Obie Zimmerman | IVIG + Coordinated Care; IVIG Placebo + Coordinated Care; Ivabradine + Coordinated Care; Ivabradine Placebo + Coordinated Care; IVIG + Usual Care; IVIG Placebo |
| NCT06305806 | RECOVER-AUTONOMIC (Ivabradine): Randomized Trial of the Effect of Ivabradine Versus Placebo on Long COVID Symptoms | COMPLETED | PHASE2 | Kanecia Obie Zimmerman | Ivabradine; Ivabradine Placebo; Coordinated Care; Usual Care |
| NCT04186286 | A Randomized Crossover Study of Propranolol Versus Ivabradine in Postural Tachycardia Syndrome (POTS) | RECRUITING | PHASE2 | University of Calgary | Ivabradine 4-week course; Propranolol 4-week course; Placebo 4-week course |
| NCT04881318 | Compression Garments in the Community With POTS | RECRUITING | nan | University of Calgary | Waist-High Compression Tights; Abdominal Compression Garments; Medications that modulate heart rate and blood pressure |
| NCT05481177 | Comparative Cohort Study of Post-acute COVID-19 Infection With a Nested, Randomized Controlled Trial of Ivabradine for Those With Postural Orthostatic Tachycardia Syndrome. | UNKNOWN | PHASE4 | Uniformed Services University of the Health Sciences | Ivabradine |
| NCT ID | Title | Status | Phase | Sponsor | Intervention |
|---|---|---|---|---|---|
| NCT04904536 | An International, Investigator Initiated and Conducted, Pragmatic Clinical Trial to Determine Whether 40mg Atorvastatin Daily Can Improve Neurocognitive Function in Adults With Lon | ACTIVE_NOT_RECRUITING | PHASE3 | The George Institute | Atorvastatin; Standard Care |
| NCT06172803 | RESToRE: Restoring Energy With Sub-symptom Threshold Optimized Rehabilitation Exercise for Long COVID | COMPLETED | nan | Columbia University | Restoring Energy with Sub-symptom Threshold Aerobic Rehabilitation Exercise; Light Stretching/Breathing Exercises |
| NCT06974084 | A Multi-Center Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy of Maraviroc and Atorvastatin for the Treatment of Subjects With Long COVID/Post-Acute Se | NOT_YET_RECRUITING | PHASE2; PHASE3 | HealthBio, Inc. | Maraviroc (MVC); Atorvastatin, 10mg, 20mg, 40mg; Placebo, Maraviroc; Placebo, Atorvastatin |
| NCT04801940 | HElping Alleviate the Longer-term Consequences of COVID-19 (HEAL-COVID): a National Platform Trial | UNKNOWN | PHASE3 | Cambridge University Hospitals NHS Foundation Trust | Apixaban; Atorvastatin |
| NCT ID | Title | Status | Phase | Sponsor | Intervention |
|---|---|---|---|---|---|
| NCT04510194 | COVID-OUT: Early Outpatient Treatment for SARS-CoV-2 Infection (COVID-19) | COMPLETED | PHASE3 | University of Minnesota | Metformin; Placebo; Fluvoxamine; Ivermectin |
| NCT06128967 | An Adaptive, Randomized, doublE-blind, Placebo-controlled, Prospective, Pharmacological interVention Study In Participants With Long COVID-19 Syndrome: REVIVE-TOGETHER Trial | COMPLETED | PHASE3 | Cardresearch | Fluvoxamine Maleate 100 MG; Placebo; Metformin Extended Release Oral Tablet |
| NCT07280572 | RECLAIM: an Adaptive Platform Trial for the Evaluation of Treatments for Post-Acute Sequelae of SARS-CoV-2 Infection (PASC) | ENROLLING_BY_INVITATION | PHASE3 | Janneke van de Wijgert | Metformin; colchicine |
| NCT06147050 | Pilot Study of an Adaptive, Double-blind, Randomized, Placebo-controlled Study to Evaluate the Effect of Metformin in Reducing Fatigue in Long COVID Adolescent Patients With Chroni | UNKNOWN | PHASE3 | Purpose Life Sciences | Metformin; Placebo |
| NCT ID | Title | Status | Phase | Sponsor | Intervention |
|---|---|---|---|---|---|
| NCT06524739 | Double-blind, Randomized, Placebo-controlled Phase 3 Study Evaluating Efficacy and Safety of IgPro20 (Subcutaneous Immunoglobulin, HIZENTRA®) in Post-COVID-19 Postural Orthostatic | TERMINATED | PHASE3 | CSL Behring | IgPro20; Placebo |
| NCT06305780 | RECOVER-AUTONOMIC: A Platform Protocol for Evaluation of Interventions for Autonomic Dysfunction in Post-Acute Sequelae of SARS-CoV-2 Infection (PASC) | COMPLETED | PHASE2 | Kanecia Obie Zimmerman | IVIG + Coordinated Care; IVIG Placebo + Coordinated Care; Ivabradine + Coordinated Care; Ivabradine Placebo + Coordinated Care; IVIG + Usual Care; IVIG Placebo |
| NCT06305793 | RECOVER-AUTONOMIC (IVIG): Randomized Trial of the Effect of IVIG Versus Placebo on Long COVID Symptoms | ACTIVE_NOT_RECRUITING | PHASE2 | Kanecia Obie Zimmerman | IVIG (intravenous immunoglobulin); IVIG Placebo; Coordinated Care; Usual Care |
| NCT05350774 | Immunotherapy for Neurological Post-Acute Sequelae of SARS-CoV-2 (IN-PASC) | ENROLLING_BY_INVITATION | PHASE2 | National Institute of Neurological Disorders and Stroke (NINDS) | IV normal saline; IV immunoglobulin |
| NCT ID | Title | Status | Phase | Sponsor | Intervention |
|---|---|---|---|---|---|
| NCT04961190 | A Comparison of Prolonged Exposure Therapy, Pharmacotherapy, and Their Combination for PTSD: What Works Best, and for Whom | ACTIVE_NOT_RECRUITING | PHASE4 | University of Pennsylvania | Prolonged Exposure Therapy; Pharmacotherapy with paroxetine or venlafaxine XR |
| NCT06631287 | Randomized Double-Blind Placebo-Controlled Trial EValuating Baricitinib on PERSistent NEurologic and Cardiopulmonary Symptoms of Long COVID (REVERSE-LC) | RECRUITING | PHASE3 | Wes Ely | Baricitinib; Placebo |
| NCT05858515 | REVERSE-Long COVID: A Multicenter Randomized, Placebo-Controlled Clinical Trial of Immunomodulation (With Baricitinib) for Long COVID Related Cognitive Impairment and ADRD (Alzheim | WITHDRAWN | PHASE3 | Vanderbilt University Medical Center | Baricitinib 4 MG; Placebo |
| NCT ID | Title | Status | Phase | Sponsor | Intervention |
|---|---|---|---|---|---|
| NCT05178225 | Spa Rehabilitation, Antioxidant and Bioenergetic Supportive Treatment of Patients With Post-Covid-19 Syndrome | COMPLETED | nan | Comenius University | ubiquinol (reduced coenzyme Q10); mountain spa rehabilitation; 2x14 ml of peripheral blood collected in a tube with anticoagulant |
| NCT06597682 | A Randomized Controlled Basket Study for Evaluating Immunomodulatory Interventions in Post-Acute Sequelae of SARS-CoV-2 InfEction (RISE) | NOT_YET_RECRUITING | nan | Huashan Hospital | Prednisone; Budesonide/Formoterol; Vitamin C combined with Coenzyme Q10 oral treatment; Montelukast tablets oral treatment |
| NCT ID | Title | Status | Phase | Sponsor | Intervention |
|---|---|---|---|---|---|
| NCT05204550 | A Randomised, Placebo-controlled Trial to Investigate the Efficacy of Intranasal Heparin Treatment to Reduce Transmission of SARS-CoV-2 Infection and COVID 19 Disease Among Househo | COMPLETED | PHASE2; PHASE3 | Murdoch Childrens Research Institute | unfractionated heparin; 0.9%sodium chloride |
| NCT05758480 | Characterization of the Immunometabolic Signature in Long COVID-19. | COMPLETED | nan | University Hospital, Angers | Blood sample (at inclusion and 6 months later); Patient questionnaires (at inclusion and 6 months later) |
| NCT ID | Title | Status | Phase | Sponsor | Intervention |
|---|---|---|---|---|---|
| NCT05946551 | Feasibility Assessment of a Decentralized Platform Adaptive Double-Blind, Randomized Controlled Trial Investigating Repurposed Drugs in the Treatment of Post-Acute Sequelae of Coro | TERMINATED | PHASE3 | Emory University | Cetirizine; Famotidine; Cetirizine Placebo; Famotidine Placebo |
| NCT07019519 | Interplay Between Gut Hormones and Autonomic Postprandial Blood Flow Regulation in Patients With POTS | RECRUITING | nan | University of Copenhagen | Saline/Placebo; GIPR antagonist; GLP-1R antagonist; CCK agonist |
| NCT ID | Title | Status | Phase | Sponsor | Intervention |
|---|---|---|---|---|---|
| NCT06316843 | A Randomized, Double-Blinded, Placebo-Controlled, Pilot Study of the Combination of Valacyclovir + Celecoxib (IMC-2) for the Treatment of Post-Acute Sequelae of SARS-CoV-2 Infectio | COMPLETED | PHASE2 | Bateman Horne Center | Valacyclovir celecoxib dose 1; Valacyclovir celecoxib dose 2; Placebo |
| NCT07597902 | SARS-CoV-2 and Herpesvirus Inhibition for Ending Long COVID Dysfunction (SHIELD) | NOT_YET_RECRUITING | PHASE2 | Icahn School of Medicine at Mount Sinai | Valacyclovir; Celecoxib; Paxlovid; Placebo |
| NCT ID | Title | Status | Phase | Sponsor | Intervention |
|---|---|---|---|---|---|
| NCT06268288 | Pilot Study--The Effects of Non-invasive Vagal Neurostimulation (nVNS) in Adolescents With Postural Orthostatic Tachycardia Syndrome (POTS) | COMPLETED | nan | Mayo Clinic | GammaCore intervention; STEPS management protocol |
| NCT04881318 | Compression Garments in the Community With POTS | RECRUITING | nan | University of Calgary | Waist-High Compression Tights; Abdominal Compression Garments; Medications that modulate heart rate and blood pressure |
| NCT ID | Title | Status | Phase | Sponsor | Intervention |
|---|---|---|---|---|---|
| NCT06967428 | Effectiveness of Metabolic Modulation in Treating Post-vaccination Syndrome: A Prospective Study | NOT_YET_RECRUITING | PHASE2 | Independent Medical Alliance | Combined metabolic modulator; Rice Protein Powder with Vitamin C |
| NCT06865261 | Effects of L-arginine and Liposomal Vitamin C Supplementation on Physical Performance and Endothelial Function in Elderly With Sarcopenia | UNKNOWN | nan | Fondazione Policlinico Universitario Agostino Gemelli IRCCS | Bioarginina C; Placebo |
| NCT ID | Title | Status | Phase | Sponsor | Intervention |
|---|---|---|---|---|---|
| NCT05911009 | A Prospective, Double-blind, Randomized, Parallel Group, Placebo Controlled, Multicentre, Phase II Study to Investigate the Efficacy, GPCR Autoantibody Neutralizing Effect, Safety, | COMPLETED | PHASE2 | Berlin Cures GmbH | BC 007 or matching placebo |
| NCT ID | Title | Status | Phase | Sponsor | Intervention |
|---|---|---|---|---|---|
| NCT05946551 | Feasibility Assessment of a Decentralized Platform Adaptive Double-Blind, Randomized Controlled Trial Investigating Repurposed Drugs in the Treatment of Post-Acute Sequelae of Coro | TERMINATED | PHASE3 | Emory University | Cetirizine; Famotidine; Cetirizine Placebo; Famotidine Placebo |
| NCT ID | Title | Status | Phase | Sponsor | Intervention |
|---|---|---|---|---|---|
| NCT04801940 | HElping Alleviate the Longer-term Consequences of COVID-19 (HEAL-COVID): a National Platform Trial | UNKNOWN | PHASE3 | Cambridge University Hospitals NHS Foundation Trust | Apixaban; Atorvastatin |
Autoantibody terms are read from autoantibody_terms.yaml and matched against CT.gov trial fields and article titles/abstracts. Out of 746 trials, 15 (2%) mention autoantibody-targeting therapies, but only 1 (0%) explicitly mention autoantibody targets or mechanisms. 14 trials test potentially autoimmune-directed therapies without explicit target/mechanism measurement. Detected literature signal: 125 articles mention autoantibody-targeting therapies and 0 articles mention specific targets/mechanisms.
| NCT ID | Title | Status | Phase | Sponsor | Intervention |
|---|---|---|---|---|---|
| NCT04920916 | Safety and Efficacy of the Treatment of Hospitalized Patients With COVID 19 Infection With an Inhibitor of IL-4 and IL-13 Signaling: A Phase IIa Trial | COMPLETED | PHASE2 | University of Virginia | Dupilumab; Placebo |
| NCT06524739 | Double-blind, Randomized, Placebo-controlled Phase 3 Study Evaluating Efficacy and Safety of IgPro20 (Subcutaneous Immunoglobulin, HIZENTRA®) in Post-COVID-19 Postural Orthostatic | TERMINATED | PHASE3 | CSL Behring | IgPro20; Placebo |
| NCT06305780 | RECOVER-AUTONOMIC: A Platform Protocol for Evaluation of Interventions for Autonomic Dysfunction in Post-Acute Sequelae of SARS-CoV-2 Infection (PASC) | COMPLETED | PHASE2 | Kanecia Obie Zimmerman | IVIG + Coordinated Care; IVIG Placebo + Coordinated Care; Ivabradine + Coordinated Care; Ivabradine Placebo + Coordinated Care; IVIG + Usual Care; IVIG Placebo |
| NCT05911009 | A Prospective, Double-blind, Randomized, Parallel Group, Placebo Controlled, Multicentre, Phase II Study to Investigate the Efficacy, GPCR Autoantibody Neutralizing Effect, Safety, | COMPLETED | PHASE2 | Berlin Cures GmbH | BC 007 or matching placebo |
| NCT05901337 | Influence of Cupping Therapy on Immune System in Post Covid- 19 Patients | COMPLETED | nan | Cairo University | Cupping therapy with convential medical treatment; Convential medical treatment |
| NCT05841498 | A Single-blinded Sham-controlled Crossover Trial to Evaluate the Effect of Immunoadsorption on Post-Corona Virus Disease (COVID)-Syndrome | COMPLETED | nan | University Medical Center Mainz | Immunoadsorption; Sham-apheresis |
| NCT06305793 | RECOVER-AUTONOMIC (IVIG): Randomized Trial of the Effect of IVIG Versus Placebo on Long COVID Symptoms | ACTIVE_NOT_RECRUITING | PHASE2 | Kanecia Obie Zimmerman | IVIG (intravenous immunoglobulin); IVIG Placebo; Coordinated Care; Usual Care |
| NCT04833673 | The Effects of Relaxation Techniques on Pain, Fatigue and Kinesiophobia in Multiple Sclerosis Patients: A Three Arms Randomized Trial | COMPLETED | nan | Hacettepe University | PMR: Progressive Muscle Relaxation; BRT:Benson Relaxation Technique |
| NCT05633472 | The Roles of Vitamin D and Microbiome in Children With Post-acute COVID-19 Syndromes (PACS) and Long COVID | COMPLETED | nan | China Medical University Hospital | Vitamin D; Placebo |
| NCT05350774 | Immunotherapy for Neurological Post-Acute Sequelae of SARS-CoV-2 (IN-PASC) | ENROLLING_BY_INVITATION | PHASE2 | National Institute of Neurological Disorders and Stroke (NINDS) | IV normal saline; IV immunoglobulin |
| NCT06952413 | An Exploratory, Placebo-controlled, Double-blind, Phase II Study of the Efficacy and Safety for Rituximab (Genetical Recombination) in Myalgia Encephalomyelitis/Chronic Fatigue Syn | RECRUITING | PHASE2 | National Center of Neurology and Psychiatry, Japan | Rituximab(Genetical Recombination); Placebo |
| NCT07316127 | A Placebo-Controlled, Double-Blind, Randomized Trial Phase I-II With Immunoadsorption in Autoimmune Long COVID | RECRUITING | PHASE2 | Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) | Immunoadsorption; Sham Comparator |
| ID | Title | Year | Journal | Source | Linked NCTs |
|---|---|---|---|---|---|
| PMID:32256619.0 | The presence of overlapping quality of life symptoms in primary antibody deficiency (PAD) and chronic fatigue syndrome (CFS). | 2020 | Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and C | PubMed | nan |
| PMID:32704114.0 | Serum proteome profiles revealed dysregulated proteins and mechanisms associated with fibromyalgia syndrome in women. | 2020 | Scientific reports | PubMed | nan |
| PMID:33524876.0 | COVID-19 convalescent plasma composition and immunological effects in severe patients. | 2021 | Journal of autoimmunity | PubMed | nan |
| PMID:33823594.0 | Morphology and Composition of Immunodiffusion Precipitin Complexes Evaluated via Microscopy and Proteomics. | 2021 | Journal of proteome research | PubMed | nan |
| PMID:34025748.0 | Anti-N-methyl-d-aspartate receptor encephalitis: A primer for acute care healthcare professionals. | 2021 | Journal of the Intensive Care Society | PubMed | nan |
| PMID:34096013.0 | Two COVID-19-related video-accompanied cases of severe ataxia-myoclonus syndrome. | 2021 | Neurologia i neurochirurgia polska | PubMed | nan |
| PMID:34309328.0 | [Consensus on treatment of multisystemic inflammatory syndrome associated with COVID-19]. | 2021 | Archivos argentinos de pediatria | PubMed | nan |
| PMID:34475972.0 | High-dose intravenous immunoglobulins as a therapeutic option in critical illness polyneuropathy accompanying SARS-CoV-2 infection: A case-based review of the literature (Review). | 2021 | Experimental and therapeutic medicine | PubMed | nan |
| PMID:34524438.0 | Risk Factors Associated With SARS-CoV-2 Infection Among Farmworkers in Monterey County, California. | 2021 | JAMA network open | PubMed | nan |
| PMID:34572574.0 | Evaluation of Immune Dysregulation in an Austrian Patient Cohort Suffering from Myalgic Encephalomyelitis/Chronic Fatigue Syndrome. | 2021 | Biomolecules | Europe PMC; PubMed | nan |
| PMID:34580754.0 | Rehabilitative management of post-acute COVID-19: clinical pictures and outcomes. | 2021 | Rheumatology international | PubMed | nan |
| PMID:34589824.0 | Anti-lysoganglioside and other anti-neuronal autoantibodies in post-treatment Lyme Disease and Erythema Migrans after repeat infection. | 2020 | Brain, behavior, & immunity - health | PubMed | nan |
| PMID:34635556.0 | Neurofascin-155 Immunoglobulin Subtypes: Clinicopathologic Associations and Neurologic Outcomes. | 2021 | Neurology | PubMed | nan |
| PMID:34635560.0 | Autoimmune Encephalitis After SARS-CoV-2 Infection: Case Frequency, Findings, and Outcomes. | 2021 | Neurology | PubMed | NCT05204550 |
| PMID:34687445.0 | A Review of Post-treatment Lyme Disease Syndrome and Chronic Lyme Disease for the Practicing Immunologist. | 2022 | Clinical reviews in allergy & immunology | Europe PMC; PubMed | nan |
| PMID:34740019.0 | Intrathecal methotrexate - Another tool for the treatment of refractory autoimmune encephalitis - Single institution cohort and literature review. | 2021 | Journal of the neurological sciences | PubMed | nan |
| PMID:34828592.0 | Back to the Future? Immunoglobulin Therapy for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome. | 2021 | Healthcare (Basel, Switzerland) | Europe PMC; PubMed | nan |
| PMID:34895744.0 | Postural tachycardia syndrome (POTS) and antiphospholipid syndrome (APS): What do we know so far? | 2022 | Revue neurologique | Europe PMC; PubMed | nan |
| PMID:34940980.0 | Intravenous immunoglobulin as an important adjunct in the prevention and therapy of coronavirus 2019 disease. | 2021 | Scandinavian journal of immunology | PubMed | nan |
| PMID:35078982.0 | Immunoglobulin signature predicts risk of post-acute COVID-19 syndrome. | 2022 | Nature communications | PubMed | nan |
| PMID:35079804.0 | Persistent Autoimmune Activation and Proinflammatory State in Post-Coronavirus Disease 2019 Syndrome. | 2022 | The Journal of infectious diseases | PubMed | nan |
| PMID:35150477.0 | Intravenous immunoglobulin: A potential treatment for the post-acute sequelae of SARS-Cov-2 infection? | 2022 | Bosnian journal of basic medical sciences | PubMed | nan |
| PMID:35194409.0 | 2021 Update on the Clinical Management and Diagnosis of Kawasaki Disease. | 2021 | Current infectious disease reports | PubMed | nan |
| PMID:35232750.0 | Peripheral Neuropathy Evaluations of Patients With Prolonged Long COVID. | 2022 | Neurology(R) neuroimmunology & neuroinflammation | PubMed | nan |
| PMID:35362030.0 | Autoimmune Encephalitis. | 2022 | Pediatrics in review | PubMed | nan |
| PMID:35569781.0 | Intravenouse immunoglobuline in dysautonomia. | 2022 | Clinical immunology (Orlando, Fla.) | Europe PMC; PubMed | nan |
| PMID:35637828.0 | Post-COVID-19 Multisystem Inflammatory Syndrome in Children and Adults: What Happens After Discharge? | 2022 | Cureus | PubMed | nan |
| PMID:35751951.0 | SARS-CoV-2 vaccinations reduce the prevalence of post-COVID Guillain-Barre syndrome. | 2022 | Clinics (Sao Paulo, Brazil) | PubMed | nan |
| PMID:36094001.0 | Postural orthostatic tachycardia syndrome: pathophysiology, management, and experimental therapies. | 2022 | Expert opinion on investigational drugs | Europe PMC; PubMed | nan |
| PMID:36286901.0 | [Hydrogen effect on the mechanisms of mucosal immunity in patients with COVID-19]. | 2022 | Terapevticheskii arkhiv | PubMed | nan |
| PMID:36414570.0 | Intravenous immunoglobulins in the treatment of post-COVID: A case-control study. | 2023 | Journal of internal medicine | PubMed | nan |
| PMID:36467487.0 | Kawasaki disease following SARS-CoV-2 infection: Stronger inflammation with no increase in cardiac complications. | 2022 | Frontiers in pediatrics | PubMed | nan |
| PMID:36680164.0 | Pharmacokinetic and Pharmacodynamic Effects of Polyclonal Antibodies against SARS-CoV2 in Mice. | 2022 | Viruses | PubMed | nan |
| PMID:36797666.0 | Serological response to vaccination in post-acute sequelae of COVID. | 2023 | BMC infectious diseases | PubMed | nan |
| PMID:36799521.0 | Hyperkinetic movement disorders following SARS-CoV-2 infection and vaccination - an update. | 2023 | Neurologia i neurochirurgia polska | PubMed | nan |
| PMID:36817368.0 | Identification of Laboratory Biomarkers for Early Detection and Clinical Management of Post-Acute Syndrome Among Survivors of the 2013-2016 West Africa Ebola Outbreak in Sierra Leone. | 2023 | Journal of blood medicine | Europe PMC; PubMed | nan |
| PMID:36818469.0 | Long-term high-dose immunoglobulin successfully treats Long COVID patients with pulmonary, neurologic, and cardiologic symptoms. | 2022 | Frontiers in immunology | PubMed | nan |
| PMID:36993874.0 | Pediatric Guillain-Barré Syndrome in a Resource Limited Setting: Clinical Features, Diagnostic and Management Challenges, and Hospital Outcome. | 2023 | Pediatric health, medicine and therapeutics | PubMed | nan |
| PMID:37070033.0 | Reply: Post-COVID-19 Myoclonus-Ataxia Syndrome-Is there Really a Need for Intravenous Immunoglobulin Treatment in all Cases? | 2023 | Movement disorders clinical practice | PubMed | nan |
| PMID:37070049.0 | Post-COVID-19 Myoclonus-Ataxia Syndrome-Is there Really a Need for Intravenous Immunoglobulin Treatment in all Cases? | 2023 | Movement disorders clinical practice | PubMed | nan |
| PMID:37168408.0 | Clinical Course and Outcome of Cardiovascular Manifestations in Children With Multisystem Inflammatory Syndrome Associated With SARS-CoV-2 Infection in Georgia. | 2023 | Cureus | PubMed | nan |
| PMID:37425897.0 | Increased circulating fibronectin, depletion of natural IgM and heightened EBV, HSV-1 reactivation in ME/CFS and long COVID. | 2023 | medRxiv : the preprint server for health sciences | Preprint (medRxiv/bioRxiv); PubMed | nan |
| PMID:37620979.0 | Impact of the COVID-19 pandemic on delays in diagnosis and treatment of tick-borne diseases endemic to southeastern USA. | 2023 | Parasites & vectors | PubMed | nan |
| PMID:37742314.0 | A brief overview of SARS-CoV-2 infection and its management strategies: a recent update. | 2024 | Molecular and cellular biochemistry | PubMed | nan |
| PMID:37745259.0 | Delayed inflammatory pulmonary syndrome: A distinct clinical entity in the spectrum of inflammatory syndromes in COVID-19 infection? | 2023 | World journal of critical care medicine | PubMed | nan |
| PMID:37831918.0 | Proinflammatory Cytokine Profiles in Both Mild Symptomatic and Asymptomatic SARS-CoV-2-Infected Egyptian Individuals and a Proposed Relationship to Post-COVID-19 Sequela. | 2023 | Viral immunology | PubMed | nan |
| PMID:38020714.0 | Blood-derived product therapies for SARS-CoV-2 infection and long COVID. | 2023 | MedComm | PubMed | nan |
| PMID:38077840.0 | The Profile of Guillain-Barré Syndrome Before and During COVID-19 Pandemic: A 5-Year Experience. | 2023 | Noro psikiyatri arsivi | PubMed | nan |
| PMID:38100444.0 | The Persistence of Specific Immunoglobulin A Against SARS-CoV-2 in Human Milk After Maternal COVID-19 Vaccination. | 2023 | Breastfeeding medicine : the official journal of the Academy of Breastfeeding Medicine | PubMed | nan |
| PMID:38100573.0 | Intravenous immunoglobulin as a potential treatment for long COVID. | 2023 | Expert opinion on biological therapy | PubMed | nan |
| NCT ID | Title | Status | Phase | Sponsor | Intervention |
|---|---|---|---|---|---|
| NCT06952413 | An Exploratory, Placebo-controlled, Double-blind, Phase II Study of the Efficacy and Safety for Rituximab (Genetical Recombination) in Myalgia Encephalomyelitis/Chronic Fatigue Syn | RECRUITING | PHASE2 | National Center of Neurology and Psychiatry, Japan | Rituximab(Genetical Recombination); Placebo |
| NCT05682196 | Open-label, Randomized Controlled Trial to Assess Efficacy and Safety of Rituximab in Patients With Acute Rheumatic Fever in Africa | SUSPENDED | PHASE2 | African Academy of Methodology and Statistics | Rituximab added to standard of care treatment; standard of care treatment alone |
| NCT04507477 | Ex-vivo Delivery of Rituximab to Prevent Post-transplant Lymphoproliferative Disease in Epstein-Barr Virus Mismatch Lung Transplant Recipients: A Pilot Trial | UNKNOWN | PHASE1; PHASE2 | University Health Network, Toronto | Rituximab |
| ID | Title | Year | Journal | Source | Linked NCTs |
|---|---|---|---|---|---|
| PMID:34011618.0 | Risk factors evaluation of post-transplant lymphoproliferative disorders after allogeneic haematopoietic stem cell transplantation with comparison between paediatric and adult. | 2021 | Journal of clinical pathology | PubMed | nan |
| PMID:34025748.0 | Anti-N-methyl-d-aspartate receptor encephalitis: A primer for acute care healthcare professionals. | 2021 | Journal of the Intensive Care Society | PubMed | nan |
| PMID:34514344.0 | Clinicopathologic Characteristics, Treatment, and Outcomes of Post-transplant Lymphoproliferative Disorders: A Single-institution Experience Using 2017 WHO Diagnostic Criteria. | 2021 | HemaSphere | PubMed | nan |
| PMID:34740019.0 | Intrathecal methotrexate - Another tool for the treatment of refractory autoimmune encephalitis - Single institution cohort and literature review. | 2021 | Journal of the neurological sciences | PubMed | nan |
| PMID:35017336.0 | Posttransplant lymphoproliferative disorder in renal transplant recipients: Experience from a Tertiary Care Center. | 2021 | Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center f | PubMed | nan |
| PMID:35165770.0 | The impact of the ongoing COVID-19 pandemic on the management of rheumatic disease: a national clinician-based survey. | 2022 | Rheumatology international | PubMed | nan |
| PMID:35169813.0 | DMARD disruption, disease flare, and prolonged symptom duration after acute COVID-19 among participants with rheumatic disease: A prospective study. | 2022 | medRxiv : the preprint server for health sciences | PubMed | nan |
| PMID:35280260.0 | Blunted Post-COVID-19 Humoral Immunity in Patients With CNS Demyelinating Disorders on Anti-CD20 Treatments. | 2022 | Frontiers in neurology | PubMed | nan |
| PMID:35362030.0 | Autoimmune Encephalitis. | 2022 | Pediatrics in review | PubMed | nan |
| PMID:35617780.0 | DMARD disruption, rheumatic disease flare, and prolonged COVID-19 symptom duration after acute COVID-19 among patients with rheumatic disease: A prospective study. | 2022 | Seminars in arthritis and rheumatism | PubMed | nan |
| PMID:36298697.0 | New-Onset and Relapsed Membranous Nephropathy post SARS-CoV-2 and COVID-19 Vaccination. | 2022 | Viruses | PubMed | nan |
| PMID:36541031.0 | SARS-CoV-2 infection and vaccination in patients with hairy-cell leukaemia. | 2023 | British journal of haematology | PubMed | nan |
| PMID:36556158.0 | Post-Transplant Lymphoproliferative Disease (PTLD) after Allogeneic Hematopoietic Stem Cell Transplantation: Biology and Treatment Options. | 2022 | Journal of clinical medicine | PubMed | NCT06666153 |
| PMID:36728717.0 | Gastric dysmotility and gastrointestinal symptoms in myalgic encephalomyelitis/chronic fatigue syndrome. | 2023 | Scandinavian journal of gastroenterology | Europe PMC; PubMed | nan |
| PMID:36730360.0 | Endothelial dysfunction in ME/CFS patients. | 2023 | PloS one | Europe PMC; OpenAlex; PubMed | nan |
| PMID:37053555.0 | Decoding the molecular heterogeneity of pediatric monomorphic post-solid organ transplant lymphoproliferative disorders. | 2023 | Blood | Europe PMC; PubMed | nan |
| PMID:38051286.0 | Clinicopathologic Spectrum of Pediatric Posttransplant Lymphoproliferative Diseases Following Solid Organ Transplant. | 2024 | Archives of pathology & laboratory medicine | Europe PMC; PubMed | nan |
| PMID:38902864.0 | COVID-19 Infection in Multiple Sclerosis Patients Treated with Rituximab Compared to Natalizumab and Healthy Controls: A Real-World Multicenter Study. | 2024 | Annals of Indian Academy of Neurology | PubMed | nan |
| PMID:38914466.0 | Factors influencing mortality in COVID-19-associated mucormycosis: The international ID-IRI study. | 2024 | Medical mycology | PubMed | nan |
| PMID:39042627.0 | Six-year follow-up of participants in two clinical trials of rituximab or cyclophosphamide in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome. | 2024 | PloS one | Europe PMC; OpenAlex; PubMed | nan |
| PMID:39370123.0 | The Outcome of SARS-CoV-2 Infection in Patients with Lymphoma and the Risk Factors for the Development of Pneumonia. | 2024 | Infection & chemotherapy | PubMed | nan |
| PMID:40691482.0 | The characteristic change of autoimmune encephalitis after the COVID-19 epidemic in Guangxi, China. | 2025 | Scientific reports | PubMed | nan |
| PMID:40742647.0 | Rituximab in the COVID-19 era: The impact of albumin and IgG on patients with immune-mediated inflammatory diseases. | 2025 | Clinical rheumatology | PubMed | nan |
| PMID:41057909.0 | Development and validation of blood-based diagnostic biomarkers for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) using EpiSwitch® 3-dimensional genomic regulatory immuno-genetic profiling. | 2025 | Journal of translational medicine | OpenAlex; PubMed | nan |
| PMID:41089328.0 | Immunotherapies for postural orthostatic tachycardia syndrome, other common autonomic disorders, and Long COVID: current state and future direction. | 2025 | Frontiers in cellular and infection microbiology | Europe PMC; Preprint (medRxiv/bioRxiv); PubMed | nan |
| PMID:41678174.0 | Efficacy of rituximab treatment in a post-COVID-19 vaccine myositis overlapping to systemic sclerosis: a histological follow-up. | 2026 | Clinical and experimental rheumatology | Europe PMC; PubMed | nan |
| PMID:41904946.0 | Autoimmune Encephalitis in Acute Care-Pathology, Diagnosis, and Management. | 2026 | Advanced science (Weinheim, Baden-Wurttemberg, Germany) | Europe PMC; PubMed | nan |
| PMID:40430026.0 | HERV Dysregulation in a Case of Myalgic Encephalomyelitis and Multiple Sclerosis Responsive to Rituximab. | 2025 | nan | Europe PMC; Preprint (medRxiv/bioRxiv) | nan |
| DOI | A Proposed Mechanism for ME/CFS Invoking Macrophage FcγRI and Interferon Gamma | 2025 | nan | Preprint (medRxiv/bioRxiv) | nan |
| PMID:40953347.0 | Child Neurology: Parainfectious Anti-NMDAR Encephalitis With Anti-MOG and Anti-AQP4 Seropositivity in an Infant. | 2025 | nan | Europe PMC | nan |
| PMID:40694749.0 | Pearls & Oy-Sters: Pan-Neurofascin Nodo-Paranodopathy Presenting as Fulminant Guillain-Barré Syndrome. | 2025 | nan | Europe PMC | nan |
| PMID:38644987.0 | Successful Treatment of Refractory Post-Transplant Lymphoproliferative Disorder With Chimeric Antigen Receptor T-Cell Therapy in a Heart Transplant Recipient. | 2024 | nan | Europe PMC | nan |
| PMID:39908479.0 | Novel Approaches to Treatment of Immune-Mediated Chronic Intestinal Pseudo-Obstruction. | 2025 | nan | Europe PMC | nan |
| PMID:39443424.0 | Severe progression of a young-onset non-paraneoplastic Lambert-Eaton myasthenic syndrome. | 2025 | nan | Europe PMC | nan |
| NCT ID | Title | Status | Phase | Sponsor | Intervention |
|---|---|---|---|---|---|
| NCT05445674 | Plasma Exchange Therapy for Post- COVID-19 Condition: A Pilot, Randomized Double-Blind Study | COMPLETED | PHASE2 | Fundación FLS de Lucha Contra el Sida, las Enfermedades Infecciosas y la Promoción de la Salud y la Ciencia | Plasma Exchange Procedure; Sham Plasma Exchange Procedure |
| NCT05543590 | Effect of Plasmapheresis on Clinical Improvement and Biological Parameters of Patients With Long-haul COVID: PLEXCOVIL Study, a Randomized Controlled Study. | WITHDRAWN | nan | Hôpital Européen Marseille | Plasmapheresis; Blood collection; Stool samples; PET scan; Cycle ergometer stress test; Questionnaires at baseline; Medical consultations |
| ID | Title | Year | Journal | Source | Linked NCTs |
|---|---|---|---|---|---|
| PMID:34025748.0 | Anti-N-methyl-d-aspartate receptor encephalitis: A primer for acute care healthcare professionals. | 2021 | Journal of the Intensive Care Society | PubMed | nan |
| PMID:34580754.0 | Rehabilitative management of post-acute COVID-19: clinical pictures and outcomes. | 2021 | Rheumatology international | PubMed | nan |
| PMID:34740019.0 | Intrathecal methotrexate - Another tool for the treatment of refractory autoimmune encephalitis - Single institution cohort and literature review. | 2021 | Journal of the neurological sciences | PubMed | nan |
| PMID:35362030.0 | Autoimmune Encephalitis. | 2022 | Pediatrics in review | PubMed | nan |
| PMID:35751951.0 | SARS-CoV-2 vaccinations reduce the prevalence of post-COVID Guillain-Barre syndrome. | 2022 | Clinics (Sao Paulo, Brazil) | PubMed | nan |
| PMID:37342848.0 | Post-COVID-19 cholangiopathy: Current understanding and management options. | 2023 | World journal of gastrointestinal surgery | PubMed | nan |
| PMID:37436788.0 | New-onset and relapsed thrombotic microangiopathy post-COVID-19 vaccination. | 2023 | Journal of medical virology | PubMed | nan |
| PMID:37491597.0 | Plasmapheresis to remove amyloid fibrin(ogen) particles for treating the post-COVID-19 condition. | 2023 | The Cochrane database of systematic reviews | PubMed | nan |
| PMID:38077840.0 | The Profile of Guillain-Barré Syndrome Before and During COVID-19 Pandemic: A 5-Year Experience. | 2023 | Noro psikiyatri arsivi | PubMed | nan |
| PMID:39313792.0 | Utilization frequency and patient-reported effectiveness of symptomatic therapies in post-COVID syndrome. | 2024 | BMC public health | Europe PMC; OpenAlex; PubMed | nan |
| PMID:39389388.0 | A review of intravenous immunoglobulin in the treatment of neuroimmune conditions, acute COVID-19 infection, and post-acute sequelae of COVID-19 Syndrome. | 2025 | Brain, behavior, and immunity | Europe PMC; PubMed | nan |
| PMID:39994269.0 | Plasma exchange therapy for the post COVID-19 condition: a phase II, double-blind, placebo-controlled, randomized trial. | 2025 | Nature communications | Europe PMC; OpenAlex; PubMed | NCT05445674 |
| PMID:40507564.0 | The Effect on Quality of Life of Therapeutic Plasmapheresis and Intravenous Immunoglobulins on a Population of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Patients with Elevated β-Adrenergic and M3-Muscarinic Rece | 2025 | Journal of clinical medicine | Europe PMC; PubMed | nan |
| PMID:41089328.0 | Immunotherapies for postural orthostatic tachycardia syndrome, other common autonomic disorders, and Long COVID: current state and future direction. | 2025 | Frontiers in cellular and infection microbiology | Europe PMC; Preprint (medRxiv/bioRxiv); PubMed | nan |
| PMID:41349230.0 | Transverse myelitis following COVID-19 infection or vaccination: Clinical outcomes and imaging characteristics compared with idiopathic cases. | 2026 | Multiple sclerosis and related disorders | PubMed | nan |
| PMID:41904946.0 | Autoimmune Encephalitis in Acute Care-Pathology, Diagnosis, and Management. | 2026 | Advanced science (Weinheim, Baden-Wurttemberg, Germany) | Europe PMC; PubMed | nan |
| DOI | Effect on Quality of Life of Therapeutic Plasmapheresis in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Patients with Elevated Ꞵ-Adrenergic and M3-Muscarinic Receptor Antibodies – a Pilot Study | 2025 | nan | Preprint (medRxiv/bioRxiv) | nan |
| PMID:36008726.0 | Immunotherapy with subcutaneous immunoglobulin or plasmapheresis in patients with postural orthostatic tachycardia syndrome (POTS). | 2023 | nan | Europe PMC | nan |
| PMID:41153561.0 | Pediatric Cardiac Arrest Secondary to Guillain-Barré Syndrome-Induced Dysautonomia. | 2025 | nan | Europe PMC | nan |
| PMID:41069916.0 | Therapeutic Plasma Exchange in Postural Tachycardia Syndrome (POTS). | 2025 | nan | Europe PMC | nan |
| PMID:39525152.0 | Unveiling the Devastating Impact of Atypical and Rapidly Evolving Guillain-Barre Syndrome: A Report of Two Cases. | 2024 | nan | Europe PMC | nan |
| PMID:40631640.0 | Unmasking Anti-CASPR2 Syndrome in a Patient Treated for Myasthenia Gravis in the Era of New Treatments. | 2025 | nan | Europe PMC | nan |
| PMID:39443424.0 | Severe progression of a young-onset non-paraneoplastic Lambert-Eaton myasthenic syndrome. | 2025 | nan | Europe PMC | nan |
| PMID:38736760.0 | Thrombosis With Thrombocytopenia and Post-COVID-Vaccination Syndrome With Anti-G-Protein-Coupled Receptor (GPCR) Antibodies Treated With Therapeutic Plasma Exchange. | 2024 | nan | Europe PMC | nan |
| NCT ID | Title | Status | Phase | Sponsor | Intervention |
|---|---|---|---|---|---|
| NCT05911009 | A Prospective, Double-blind, Randomized, Parallel Group, Placebo Controlled, Multicentre, Phase II Study to Investigate the Efficacy, GPCR Autoantibody Neutralizing Effect, Safety, | COMPLETED | PHASE2 | Berlin Cures GmbH | BC 007 or matching placebo |
| ID | Title | Year | Journal | Source | Linked NCTs |
|---|---|---|---|---|---|
| PMID:40735347.0 | Safety, tolerability and clinical effects of rovunaptabin, also known as BC007 on fatigue and quality of life in patients with Post-COVID syndrome (reCOVer): a prospective, exploratory, placebo-controlled, double-blind, | 2025 | EClinicalMedicine | Europe PMC; PubMed | nan |
| DOI | Safety, tolerability and clinical effects of BC007 (Rovunaptabin) on fatigue and quality of life in patients with post-COVID syndrome (reCOVer): a prospective, exploratory, randomised, placebo-controlled, double-blind, c | 2024 | nan | Preprint (medRxiv/bioRxiv) | nan |
Very few trials explicitly mention autoantibody targets or mechanisms, so a separate target chart is suppressed. This sparsity is itself part of the evidence gap.
Industry vs. academic vs. NIH split tells you who's funding Post-COVID research. The top-15 sponsors view shows whether the field is dominated by a few large programs (RECOVER) or fragmented across many small efforts.
Coverage of measurement categories across primary endpoints (746 trials) and secondary endpoints (617 trials). Categories with strong presence in both columns are core constructs the KG must support; categories that appear mostly as secondary are tracked alongside as comorbidity or safety signals. The split also tells you which constructs carry explicit hypothesis weight (primary) versus which are recorded for context (secondary).
| NCT ID | Title | Status | Phase | Sponsor | Primary endpoint | Secondary endpoint |
|---|---|---|---|---|---|---|
| NCT05104749 | Homeopathic Treatment of Post-acute COVID-19 Syndrome- A Pilot Randomized Controlled Trial | COMPLETED | PHASE3 | Southwest College of Naturopathic Medicine | Fatigue Assessment Scale (FAS); SF-36 Physical Composite Score (PCS); SF-36 Mental Composite Score (MCS) | Patient Health Questionnaire-9 (PHQ-9); Measure Yourself Medical Outcomes Profile Symptom #1; Measure Yourself Medical Outcomes Profile Symptom #2; Patient Doctor Depth of Relationship (PDDR) |
| NCT05618587 | Effect of Low-dose Lithium Therapy on Long COVID Symptoms: a Randomized Controlled Trial. | COMPLETED | PHASE2 | State University of New York at Buffalo | Fatigue Severity Scale; Brain Fog Severity Scale | Patient Global Impression of Change (PGIC); Well-Being Scale; Short Form-12 Health Survey (1-week Modification); Desire to Continue Therapy; Generalized Anxiety Disorder-2 Scale; Headache and Body Pain Bother Scale; Insomnia Severity Index; Sense of Smell and |
| NCT05592418 | A Randomized, Double Blind, Placebo Controlled Study to Evaluate the Efficacy and Safety of Ampligen® in Patients With Post-COVID Conditions | COMPLETED | PHASE2 | AIM ImmunoTech Inc. | Change From Baseline to Week 13 in PROMIS Fatigue Score (T-Score) | Change From Baseline to Week 6 in PROMIS Fatigue Score (T-Score); Change From Baseline to Week 13 in PROMIS Fatigue Score (T-Score), Excluding Response to Item Seven; Change From Baseline to Week 6 and Week 13 in Distance Traveled During 6-minute Walk Test (6M |
| NCT04141696 | A Proof-of-Concept Trial on the Effect of Ketamine on Fatigue | COMPLETED | PHASE1; PHASE2 | National Institute of Nursing Research (NINR) | Percentage Change in Self-reported Fatigue Visual Analog Scale (VAS) Scale | Percentage Change in Self-reported Fatigue Visual Analog Scale (VAS) Scale - Day 7; Areas Under the Curve (AUC) for Percentage Changes in Self-reported Fatigue VAS Score - Through Day 7; Mean Physical Activity Count Using Actigraphy; Fatigue Level Measured by |
| NCT05126563 | A Randomized, Double-blinded, Single-center, Phase 2 Efficacy, and Safety Study of Allogeneic HB-adMSCs for the Treatment of Patients With Chronic Post-COVID-19 Syndrome. | COMPLETED | PHASE2 | Hope Biosciences Research Foundation | Changes From Baseline in Visual Analog Scale of Neurological Symptoms. - Extreme Fatigue (ANCOVA Model); Changes From Baseline in Visual Analog Scale of Neurological Symptoms.. - Brain Fog (ANCOVA Model); Changes From Baseline in Visual Analog Scale of Neurolo | Changes From Baseline in Visual Analog Scale of Non-Neurological Symptoms. - Dyspnea at Rest (ANCOVA Model); Changes From Baseline in Visual Analog Scale of Non-Neurological Symptoms. - Dyspnea During Activity (ANCOVA Model); Changes From Baseline in Visual An |
| NCT06208696 | Pilot Study to Evaluate the Role of an Evidenced-based Chronic-disease Self-management Program to Support Challenges Experiencing Patients Living With Long-COVID and Chronic Diseas | COMPLETED | nan | University of Puerto Rico | Assessment of the Impact of Health-related Quality of Life; Assessment of the Fatigue in the Impact of the Health-related Quality of Life; Assessment of the Anxiety in the Impact of Health-related Quality of Life | Chronic Diseases Self-management; Auto-efficacy for Disease Management |
| NCT05795816 | The Effectiveness of Testofen on Energy, Fatigue, Mental Acuity, and Other Quality of Life Symptoms Post COVID-19 Infection | COMPLETED | PHASE3 | RDC Clinical Pty Ltd | Change in Energy and Fatigue; Change in Energy and Fatigue | Change in Memory; Change in Mental Acuity; Change in Muscle Strength (Hand grip); Change in Hair loss/growth; Change in Libido; Change in Stress and Mood; Change in Quality of Life Indicators; Change in Pathology results via Blood test; Change in Weight; Heigh |
| NCT04622293 | A Double-Blind, Randomized, Placebo-Controlled, Single-Center, Flexible Titration Study Evaluating the Efficacy of Solriamfetol in Treating Fatigue and Cognitive Symptoms in Adults | COMPLETED | PHASE4 | Rochester Center for Behavioral Medicine | Fatigue Symptom Inventory (FSI) | BRIEF-A |
| NCT05642923 | Post-COVID-19 Chronic Fatigue Syndrome | COMPLETED | PHASE4 | ClinAmygate | Fatigue scale; Fatigue scale; Fatigue scale | Incidence of adverse events |
| NCT06128967 | An Adaptive, Randomized, doublE-blind, Placebo-controlled, Prospective, Pharmacological interVention Study In Participants With Long COVID-19 Syndrome: REVIVE-TOGETHER Trial | COMPLETED | PHASE3 | Cardresearch | Improvement on Fatigue Severity Score Scale (FSS) | Improvement on Fatigue Severity Score Scale (FSS); Improvement on Fatigue Severity Score Scale (FSS); Reduction on any cause hospitalization; Safety of metformin; Safety of Fluvoxamine; Death of any cause |
| NCT06316843 | A Randomized, Double-Blinded, Placebo-Controlled, Pilot Study of the Combination of Valacyclovir + Celecoxib (IMC-2) for the Treatment of Post-Acute Sequelae of SARS-CoV-2 Infectio | COMPLETED | PHASE2 | Bateman Horne Center | Fatigue assessed with the Patient-Reported Outcomes Measurement Information System (PROMIS) Fatigue 7a Instrument | nan |
| NCT04604704 | Pilot Study Into Low Dose Naltrexone (LDN) and Nicotinamide Adenine Dinucleotide (NAD+) for Treatment of Patients With Post-COVID-19 Syndrome (Long-COVID19) | COMPLETED | PHASE2 | AgelessRx | Reduction of fatigue in post-COVID-19 syndrome by treatment with LDN and NAD+ | Improvement of quality of life in post-COVID-19 syndrome by treatment with LDN and NAD+. |
| NCT05911009 | A Prospective, Double-blind, Randomized, Parallel Group, Placebo Controlled, Multicentre, Phase II Study to Investigate the Efficacy, GPCR Autoantibody Neutralizing Effect, Safety, | COMPLETED | PHASE2 | Berlin Cures GmbH | Mean change from baseline in score on FACIT-FS scale at Day 30. | To compare GPCR AAB neutralizing effect of BC 007 1350 mg with that of placebo.; To compare GPCR AAB neutralizing effect of BC 007 1900 mg with that of placebo.; To compare GPCR-AAB neutralizing effect of BC 007 1350 mg with that of BC 007 1900 mg |
| NCT05430152 | A Double Blind Randomized Trial of Low-dose Naltrexone for Post-COVID Fatigue Syndrome | COMPLETED | PHASE2 | Luis Nacul | Fatigue Intensity | Pain Severity; Symptom Severity; Activity Levels; Self-reported Quality of Life |
| NCT05497089 | Temelimab as a Disease Modifying Therapy in Patients With Neurological, Neuropsychological, and Psychiatric (=Neuropsychiatric) Symptoms in Post-COVID 19 or Postacute Sequelae of C | COMPLETED | PHASE2 | GeNeuro SA | Improvement in fatigue in PASC patients | Fatigue; Cognitive function; Cognitive function; Cognitive function; Cognitive function; Anxiety; Depression; Overall quality of Life; Functional impairment; Post-COVID-19 Functional Status; Safety and tolerability of Temelimab in PASC patients |
| NCT04944121 | A Phase 2, Double-blind, Placebo-controlled Study of RSLV-132 in Subjects With Post-acute COVID-19 (Long COVID) | COMPLETED | PHASE2 | Resolve Therapeutics | PROMIS Fatigue SF 7a T-score | FACIT Fatigue questionnaire; Long COVID-19-related Symptom Assessment patient questionnaire; Patient-reported Global Impression of Severity questionnaire; Digit Symbol Substitution Test; Physician Global Assessment |
| NCT05212688 | A Randomised Phase II Study to Investigate the Effectiveness of ACUpuncture for the Relief of Long COVID Related Fatigue. | COMPLETED | PHASE2 | Royal Marsden NHS Foundation Trust | General Fatigue Score | nan |
| NCT05445674 | Plasma Exchange Therapy for Post- COVID-19 Condition: A Pilot, Randomized Double-Blind Study | COMPLETED | PHASE2 | Fundación FLS de Lucha Contra el Sida, las Enfermedades Infecciosas y la Promoción de la Salud y la Ciencia | Evaluate the safety and tolerability of PE in patients with Post-Acute Covid-19 Syndrome (PCC) comparing to sham plasma exchange (placebo); Proportion of subjects with Grade 0, 1 o 2 functional disability assessed by the functional status scale (PCFS); Proport | Assess the ability of PE to improve PCC symptoms; Assess the impact of PE on quality of life in subjects with PCC; Assess the impact of PE on quality of life in subjects with PCC using MOS-HIV questionnaire; Assess the impact of PE on neurocognitive symptoms i |
| NCT06840873 | Effectiveness of a 8-week Tele-Rehabilitative Exercise Training Program on Fatigue, Symptom Severity, and Quality of Life in Nurses With Long COVID: A Randomized Controlled Trial | COMPLETED | nan | Shang-Lin Chiang | Fatigue (score); O2 pulse in ml/beat; Aerobic capacity (VO2 max in ml/kg/min ); Working load in watt; Heart rate recovery in beat/min; Anaerobic threshold (AT in ml/kg/min); Severity of long COVID symptoms (scores) | Quality of life (scores); Perceived stress (scores) |
| NCT05638620 | Evaluating the Effectiveness of Dual Sympathetic Blocks for Patients Experiencing Sympathetically-Mediated Symptoms From Post-Acute Sequelae of SARS-CoV-2 (PASC) | COMPLETED | PHASE1 | Jonathann Kuo, MD | Patient-Reported Outcomes: PROMIS-29 Score; Depression; Anxiety; Physical function; Pain interference; Fatigue; Sleep disturbance; Ability to participate in social roles and activities status | Autonomic Symptoms: COMPASS-31 Score |
| NCT06596161 | Effect or Iron Therapy on Fatigue Symptoms in Non-anemic Iron Deficient Women of Reproductive Age | COMPLETED | nan | Central Park Medical College | Fatigue Score improvemnt | nan |
| NCT06721949 | Taurine Supplementation as a Novel Therapeutic Approach for Neurocognitive Symptoms in Long COVID | RECRUITING | PHASE2; PHASE3 | University of Alberta | Mean change in Modified Fatigue Impact Scale (MFIS) from baseline to three months; Mean change in the ratio of the Trail-Making Tests A & B in the TestMyBrain cognitive testing battery from baseline to three months. | Core Outcome Set - Symptoms; Cardiovascular function; Respiratory function; Cognitive Function; Memory; Concentration; Conceptual Thinking; Social Functioning; Mental Health Status - PHQ-9; Mental Health Status - GAD-7; Post-Exertional Malaise (PEM) Symptoms; |
| NCT05216549 | Water and Land-based Exercise for Children With Post COVID-19 Condition | COMPLETED | nan | Józef Piłsudski University of Physical Education | Exercise capacity; Fatigue | Health-related quality of life; Forced vital capacity (FVC); Forced expiratory volume/one second (FEV 1); Maximal expiratory flow at 25% of forced vital capacity (MEF25) |
| NCT05840237 | REGAIN: A Randomized, Double Blind, Placebo Controlled Trial to Determine the Effects of Oxaloacetate on Improving Fatigue in Long COVID | COMPLETED | nan | Terra Biological LLC | Chalder Fatigue Score | Global Impression of Change; Up-Time |
| NCT05973136 | A Pilot Study to Evaluate the Implantation and the Impact of a Hybrid Telerehabilitation Program Based on Cardiopulmonary Rehabilitation Principles for People With Post-COVID Affec | COMPLETED | nan | Université de Sherbrooke | The feasibility of the program; Acceptability; Fatigue and post-exercise malaise | Heart rate variability (resting); Functional capacity; Exercise capacity; Lower-limb endurance (estimated) |
| NCT06535165 | Effect of 14-day Red Beetroot Juice Intake on Physical Function, Gut Microbiota Composition, and Systemic Inflammation in Adults With Long COVID-19 | COMPLETED | nan | Catholic University of the Sacred Heart | Fatigue resistance | Six-minute walk test; Flow-mediated dilation; Changes in the concentration of gut microbial species; Fecal water metabolomics; Changes in the concentration of circulating inflammatory mediators |
| NCT05710770 | Double-blinded, Randomized, Sham-controlled Trial of Immunoadsorption (IA) in Patients With Chronic Fatigue Syndrome (CFS) Including Patients With Post-acute COVID-19 CFS (PACS-CFS | COMPLETED | nan | Charite University, Berlin, Germany | Improvement in physical and mental fatigue as measured by the Chalder Fatigue Scale | Sustained improvement quantified by the Chalder Fatigue Scale; Verification of safety and tolerability of immunoadsorption in this patient population; Improvement in severity of symptoms of chronic fatigue syndrome (CFS) as measured by the Fluge score; Improve |
| NCT04308278 | Randomized, Placebo-controlled, Double Blind Study to Evaluate the Efficacy of 2LEBV® and 2LXFS® on Asthenia in Patients With an Epstein-Barr Virus Infection. | RECRUITING | PHASE4 | Labo'Life | Measure of the general fatigue scale of the Multidiensional Fatigue Inventory-20 (MFI-20) questionnaire at the end of the treatment. | Comparison of the efficacy of the treatment on physical fatigue, reduced activity, reduced motivation and mental fatigue scales on the MFI-20 questionnaire between the 2LEBV® or the 2LXFS®/2LEBV® group versus the placebo group; Comparison of the efficacy of th |
| NCT06393790 | Health Effects of a Strength Training Protocol in Women With Fibromyalgia and Healthy Individuals. | COMPLETED | nan | Catholic University of Murcia | PRE-TEST Time up and go test (TUG test); PRE-TEST 5 Times Sit to stand test (5TSTS); PRE TEST 10 meters walk test; PRE TEST 2 minutes walk; PRE TEST Upper body dinamometry; PRE TEST Lower body dinamometry; PRE TEST Sleep assessment: Karolinska Sleepiness Diary | ACUTE PRE-TEST Time up and go test (TUG test); ACUTE POST-TEST Time up and go test (TUG test); ACUTE PRE-TEST 5 Times Sit to stand test (5TSTS); ACUTE POST-TEST 5 Times Sit to stand test (5TSTS); ACUTE PRE TEST 10 meters walk test; ACUTE POST TEST 10 meters wa |
| NCT05630378 | Evaluation of a Multimodal Integrative Medicine and Naturopathy Program in an Outpatient Setting With Focus on Mind-Body Medicine and Mild Water-filtered Infrared-A Whole-body Hype | COMPLETED | nan | Universität Duisburg-Essen | Fatigue - Change from week 0 to week 11 | Quality of life 1; Hospital Anxiety and Depression; Perceived Stress; perceived Pain; Quality of life 2; Sleep Quality; Resilience |
| NCT06726772 | Post-COVID-19 Symptom Burden: Effects of an Outpatient Group Psychotherapy in Long COVID Patients | COMPLETED | nan | Cantonal Hospital of St. Gallen | Change of Fatigue Score measured with the Questionnaire "FSS" (Fatigue Severity Scale) from baseline to 8 weeks; Change of Insomnia Score measured with the Questionnaire "ISI" (Insomnia Severity Index) from baseline to 8 weeks; Change of Qu | nan |
| NCT05273372 | A Randomized Double Blind Placebo Controlled Trial to Determine the Effects of Oxaloacetate on Improving Fatigue in ME/CFS | COMPLETED | nan | Terra Biological LLC | Reduction of Fatigue | Number of participants with treatment-related adverse events as assessed by CTCAE v4.0; Physical Functioning on the SF-36; Patient Global Impression of Change Questionnaire, 7 point scale, -3 to +3, with the higher score indicating more improvement |
| NCT06814379 | Rehabilitation of Fatigue in Patients With Post-COVID-19 Syndrome | COMPLETED | nan | Universidad de Granada | Perceived Fatigue; Multidimensional Fatigue; Fatigue Severity; Fatigue Impact | COVID-19 information; Comorbidities; Dyspnea. The Borg Modified Scale; Dyspnea. Dyspnea-12; Dyspnea. Modified Medical Research Council (mMRC) Dyspnea Scale; Pain intensity; Psychological status; Sleep quality; Health-related Quality of life; Functional status: |
| NCT05803824 | Efficacy of Baduanjin Qigong Exercise Program on Fatigue and Postural Imbalance Following Lower Limb Burn Injury | COMPLETED | nan | Cairo University | The Brief Fatigue Inventory (BFI); b. The dynamic balance score | b. The timed up and go (TUG) test; c. The Activities-specific Balance (ABC) scale |
| NCT05841498 | A Single-blinded Sham-controlled Crossover Trial to Evaluate the Effect of Immunoadsorption on Post-Corona Virus Disease (COVID)-Syndrome | COMPLETED | nan | University Medical Center Mainz | Improvement of Post-COVID symptoms as measured by PCFS score; Change of physical and/or mental fatigue as measured by Chalder-Fatigue-scale; Change of impairment due to fatigue as measured by Bell-Score; Change of physical and/or mental fatigue as measured by | number of treatment-emergent adverse events (TEAE), serious adverse events and discontinuation of therapy because of adverse events; Prevalence of anti-adrenergic and anti-muscarinic autoantibodies in patients with PCS:; 3. Concentration of autoantibodies befo |
| NCT05531019 | COVID-19 Sequelae: Treatment and Monitoring of Persistent Symptoms, a Decentralized Approach Focus on the Patient. Use of Dietary Supplement Based on Sea Urchin Eggs With Echinochr | COMPLETED | nan | Fernando Saldarini | Change of symptoms over time-points (baseline, 4 weeks, 8 weeks, 12 weeks) during rutine medical checkup.; Change of lung capacity over four times (baseline, 4 weeks, 8 weeks, 12 weeks) assessed during spirometry.; Change of walking distance during a six minut | Change of Von Willebrand Factor over time-points (baseline, 4 weeks, 12 weeks, 12 weeks) via blood sample.; Change of D Dimer over time-points (baseline, 4 weeks, 12 weeks, 12 weeks) via blood sample.; Change of HS-CRP over time-points (baseline, 4 weeks, 8 we |
| NCT06108297 | Effect of Low-dose Lithium Therapy on Long COVID Symptoms: an Open-label, Dose-finding Study. | COMPLETED | PHASE1 | State University of New York at Buffalo | Fatigue Severity Scale (FSS); Brain Fog Severity Scale (BFSS) | Well Being Scale; Short Form-12 Health Survey; FSS scores in those with FSS score ≥28 at baseline; BFSS scores in those with FSS score ≥28 at baseline; Modified Fatigue Impact Scale; Perceived Deficits Questionnaire, 5-Item Version; Beck Depression Inventory-I |
| NCT05793736 | A Feasibility Study of an HVR Protocol Biofeedback Training to Manage Long Covid Syndrome Symptoms | COMPLETED | nan | University of Cagliari | Change from Baseline to 5 weeks and to 9 weeks in Patient Health Questionnaire-9 (PHQ-9) score; Change from Baseline to 5 weeks and to 9 weeks in Brief Fatigue Inventory (BFI) score; Change from Baseline to 5 weeks and to 9 weeks in Short Form Health Survey (S | nan |
| NCT06013072 | The Effects of 3-month Supplementation With a Pre-probiotic on Patient- and Clinician-reported Outcomes, and Brain Tissue Metabolism in Patients With Post-covid Fatigue Syndrome: a | COMPLETED | nan | University of Novi Sad, Faculty of Sport and Physical Education | Fatigue | Brain creatine; Patient-reported symptoms; Time to exhaustion |
| NCT05631171 | COVIDAI: Feasibility Study of Adhera® Fatigue Digital Program for Patients With Long COVID-related Fatigue | COMPLETED | nan | Adhera Health, Inc. | Health-related quality of life; Health-related quality of life; Health-related quality of life; Fatigue; Fatigue; Fatigue; Emotional wellness; Emotional wellness; Emotional wellness | Behavioral outcome: Usability; Behavioral outcome: Usability; Fatigue-related symptomatology; Fatigue-related symptomatology; Mood; Mood; Mood; Social, psychological and emotional wellness; Social, psychological and emotional wellness; Social, psychological an |
| NCT04833673 | The Effects of Relaxation Techniques on Pain, Fatigue and Kinesiophobia in Multiple Sclerosis Patients: A Three Arms Randomized Trial | COMPLETED | nan | Hacettepe University | Fatigue | Chronic Pain; Kinesiophobia |
| NCT07455123 | The Effect of a Self-Management Program on Fatigue, Sleep Quality, Psychological Resilience, and Occupational Balance in University Students With High Levels of Fatigue: A Randomiz | COMPLETED | nan | Hacettepe University | Change in Fatigue Severity (Piper Fatigue Scale Total Score); Change in Sleep Quality (Pittsburgh Sleep Quality Index Total Score); Change in Psychological Resilience (Psychological Resilience Scale for Adults Total Score); Change in Occupational Balance (Occu | nan |
| NCT06635928 | Assessing Fatigue and Attention in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Patients Before and After Treatment With Bright Light Therapy: a Prospective Randomized Contro | COMPLETED | nan | Medical University of Vienna | Chalder Fatigue Score | Test of Attentional Performance |
| NCT05252481 | Modulation of Post-COVID-19 Fatigue Using Transcranial Direct Current Stimulation. Transcranial Direct Stimulation for Persistent Fatigue Treatment Post-COVID-19 | COMPLETED | nan | Hospital San Carlos, Madrid | Change in Fatigue | Change in cognition; Change in depressive symptoms; Change in quality of life |
| NCT06980636 | Shengmai Liquid for Long COVID Fatigue: a Randomized Placebo-controlled Trial. | RECRUITING | PHASE4 | Beijing University of Chinese Medicine | The degree of improvement in patient fatigue, measured using the Modified Fatigue Impact Scale (MFIS) | Traditional Chinese Medicine Syndrome Score Scale; Improvement in depression, assessed using the 17-item Hamilton Depression Scale; Improvement in anxiety, assessed using the Hamilton Anxiety Scale (HAMA); Improvement in sleep quality, assessed using the Pitts |
| NCT04794036 | Efficacy of an Asynchronous Telerehabilitation Programme in Post-COVID-19 Patients: a Feasibility Study | COMPLETED | nan | Universidad San Jorge | Fatigue Severity Level | Adherence; Engagement; Satisfaction level; Incidents; Maximum Leg Strength Endurance; Maximum Arm Strength Endurance; Submaximum Aerobic Capacity Walking; Post-COVID Functional Status; Depression, Anxiety and Stress; Self-efficacy; Behavior in sport; Perceived |
| NCT04158427 | Intestinal Microbiota and Chronic Fatigue Syndrome. Effect of Fecal Transplant on Health Related Quality of Life of the Patients With Chronic Fatigue Syndrome | COMPLETED | nan | Tampere University Hospital | Health related quality of life assessed by EQ-5D-5L questionnaire; Health related quality of life assessed by 15D questionnaire; Health related quality of life assessed by Modified Fatigue Impact Scale; Ability to work or study; Visual Analog Fatigue Scale | Health related quality of life assessed by EQ-5D-5L questionnaire; Health related quality of life assessed by 15D questionnaire; Health related quality of life assessed by Modified Fatigue Impact Scale; Ability to work or study; Visual Analog Fatigue Scale |
| NCT04049331 | Improving Patient-Important Outcomes With Testosterone Replacement in Hypogonadal Men With a Prior History of Cancer | ACTIVE_NOT_RECRUITING | PHASE2 | Seattle Institute for Biomedical and Clinical Research | Fatigue change | Sexual function change; Sexual function change; Body composition change; Changes to mood and well-being; Muscle strength change; Sleep quality change; Sleep quality change; Sleep quality change; Daily physical activity change |
| NCT06597396 | A Phase 2a Randomized, Dose Ranging, Double-Blind, 3-Arm Study to Investigate Orally Administered Abrocitinib Compared With Placebo in Non-Hospitalized Symptomatic Adult Participan | ACTIVE_NOT_RECRUITING | PHASE2 | Beth Israel Deaconess Medical Center | Change from baseline in mean score for FACIT (Functional Assessment of Chronic Illness Therapy) Fatigue Scale | Change from baseline for EQ(EuroQol)-5D-5L values and visual analog scale (VAS) score to Day 84; Change from baseline in PASC Symptom PRO (patient reported outcome) Instrument score to Day 84; Safety-related clinical laboratory test abnormalities and related a |
| NCT07057999 | Effects of the MIND Diet on Fatigue, Quality of Life, and Brain Fog in Patients With Multiple Sclerosis: A Randomized Controlled Trial | COMPLETED | nan | Betul Uner | The Effect of the MIND Diet on Quality of Life; Effect of the MIND diet on fatigue in MS patients; The effect of the MIND diet on brain fog in MS patients | The effect of the MIND diet on blood parameters; Effect of the applied MIND diet on body composition |
| NCT05507190 | Self-management of Post COVID-19 Syndrome Using Wearable Biometric Technology | COMPLETED | nan | University of Manitoba | Change in lung capacity; Change in dyspnea; Change in fatigue; Chronic fatigue syndrome; Health-related quality of life; Postural orthostatic hypotension; Exercise capacity | Symptoms change; Patient satisfaction with the study |
| NCT05954325 | Extracorporal Apheresis Hannover Medical School Study in Post COVID-19 Patients | COMPLETED | nan | Hannover Medical School | Chalder Fatigue Scale | Cognitive Function; Post exertional malaise symptoms; Measure of health status; Depression and Anxiety; Autonomic dysfunction; 6-min. walk test; Hand grip strength; Optical coherence tomography angiography; Cranial magnetic resonance imaging and spectroscopy; |
| NCT07263854 | Effects of Lower Extremity Neuromuscular Facilitation on Gait, Balance and Fatigue in Patients With Multiple Sclerosis: A Randomized Controlled Study | COMPLETED | nan | Sanko University | static balance; dynamic balance; gait; fatigue | nan |
| NCT07363655 | Effects of a Rehabilitation Programme Focused on Energy Management in People With Myalgic Encephalomyelitis / Chronic Fatigue Syndrome | COMPLETED | nan | Escola Superior de Saúde Norte da Cruz Vermelha Portuguesa | Functional Assessment; Quality of Life Measure; Fatigue Assessment | nan |
| NCT05677932 | Bright Light Therapy for Post-COVID-19 Fatigue | COMPLETED | nan | Chinese University of Hong Kong | Change of fatigue symptoms | Change of insomnia symptoms; Change of depressive symptoms; Change of anxiety symptoms |
| NCT07128082 | The Long COVID Treatment Trial | ACTIVE_NOT_RECRUITING | PHASE2 | Scripps Translational Science Institute | Primary Objective 1: Changes in fatigue severity score, measured by Fatigue Severity Scale (FSS) | Secondary Outcome: Changes in overall health, measured by European Quality of Life 5 day, 5 level (EQ-5D-5L) scores; Secondary Outcome: Presence of and changes in post-exertional malaise, a condition that occurs in subsets of Long COVID and IACIs, measured by |
| NCT04301609 | Randomized, Comparative, Double-blind, and Placebo-controlled Clinical Trial to Assess the Improvement of Fatigue, Sleep, Anxiety / Depression, Neurovegetatives Alterations and Qua | COMPLETED | nan | Vitae Health Innovation | Perception of fatigue (FIS-40). | Sleep dysfunction (Pittsburg questionnaire); Hospital anxiety-depression scale (HAD); Quality of life (SF-36) |
| NCT04435002 | The Effect of Acupressure on Fatigue in Individuals With Chronic Fatigue Syndrome | COMPLETED | nan | Istanbul Medipol University Hospital | Fatigue Severity Scale | Beck Depression Inventory; Short Form-36 questionnaire |
| NCT06379737 | Valutazione Degli Esiti a Medio-lungo Termine Della Sindrome Long Covid in Pazienti Trattati Con un Protocollo di Riabilitazione in Ambiente Termale o in Teleriabilitazione | COMPLETED | nan | Padua University General Hospital | Numerical Rating Scale (NRS); Hand grip strength; Barthel Dyspnea Scale; Fatigue Assessment Scale; Beck's Depression Inventory (BDI; Beck Anxiety Inventory (BAI); 12-Item Short Form Health Survey (SF-12) | Patients satisfaction |
| NCT07359482 | sElective Serotonin reuPtake inhibitoRs In posT-covid: ESPRIT | NOT_YET_RECRUITING | PHASE3 | Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) | Fatigue severity | Fatigue severity; Cognitive functioning; Cognitive functioning; PEM; POTS (National Aeronautics and Space Administration (NASA) lean test; POTS; Health-related Quality of Life; Disability; Side effects; Side effects; Brain Perfusion (optional MRI substudy); Br |
| NCT05363514 | A Pilot Study of Low Dose Naltrexone Use in Patients With Postural Orthostatic Tachycardia Syndrome | NOT_YET_RECRUITING | PHASE4 | University of Calgary | Fatigue Visual Analogue Scale (VAS) | RAND 36 Health Related Quality of Life Score; Cytokines |
| NCT05967052 | Investigation of Pregabalin Therapy and Complex Rehabilitation in Treating Chronic Fatigue Associated With Post-COVID Syndrome | RECRUITING | PHASE2 | National Institute of Geriatrics, Rheumatology and Rehabilitation, Poland | Change in fatigue intensity expressed as a difference in Multidimensional Fatigue Inventory-20 (MFI-20) score; Walking distance as a difference in score from the 6 Minute Walking Test | Change in the level of satisfaction with life expressed in the form of the result of the Satisfaction with Life Scale (Juczyński); Change in the result obtained in the "Beck Depression Inventory (BDIII)" study; Change in the result obtained in the an |
| NCT06978582 | Effectiveness and Safety of a Tele-rehabilitation Program Based on Mindful and Conscious Movement-based Exercise vs Conventional Low-intensity Exercise on Fatigue and Related Varia | ACTIVE_NOT_RECRUITING | nan | University of Seville | Fatigue | Heart Rate Variability; Perceived pain; Perceived Quality of life; Physical function; Interoceptive awareness; Anxiety and depression levels; Perceived sleep quality; Fear of movement; Somatic vigilance; Treatment feasibility |
| NCT06974084 | A Multi-Center Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy of Maraviroc and Atorvastatin for the Treatment of Subjects With Long COVID/Post-Acute Se | NOT_YET_RECRUITING | PHASE2; PHASE3 | HealthBio, Inc. | Fatigue | Improvement in dysautonomia symptoms as reflected by the Composite Autonomic Symptom Score (COMPASS-31); Improvement in Dyspnea; Improved Cognitive Function, measured by the PROMIS (Patient-Reported Outcomes Measurement Information System) Cognitive Function v |
| NCT06821087 | Evaluating the Neuromodulatory Effect of Ketamine in Long COVID: A Pilot Study Targeting Fatigue and Neurocognitive Symptoms | ENROLLING_BY_INVITATION | PHASE2 | University of Texas at Austin | PROMIS SF v1.0 - Fatigue 8a; PROMIS SF v2.0 Cognitive Function 4a; BrainCheck Cognitive Battery; Number of participants with treatment-related adverse events as assessed by standardized interview | PROMIS Global 10 v1.2; NASA Task Load Index (NASA-TLX); Patient Health Questionnaire-9 (PHQ-9); Generalized Anxiety Disorder-7 (GAD-7); Depression in Medically Ill 10 Scale (DMI-10); Long COVID Review of Systems; Neuroimaging (MRI) Outcomes; Serum Biomarker An |
| NCT06739720 | A Randomized, Waitlist-controlled Clinical Study on the Efficacy and Safety of Lingzhi-containing Dietary Supplement CP003 on Chronic Fatigue and Post-COVID Fatigue | NOT_YET_RECRUITING | PHASE2; PHASE3 | The University of Hong Kong | Mean difference in Chalder Fatigue Score | Mean difference in Chalder Fatigue Score; Mean difference in 36-Item Short-Form Health Survey; Mean difference in Fatigue Severity Score; mean difference in (PROMIS) Short Form Fatigue 7A survey; Mean difference in hospital anxiety and depression scale; Mean d |
| NCT06204458 | Evaluation of the Efficacy of Mild Water-filtered Infrared-A Whole-body Hyperthermia to Improve Symptoms and Quality of Life in Patients With Post-COVID Syndrome (HyPoCo) | ACTIVE_NOT_RECRUITING | nan | Universität Duisburg-Essen | Multidimensionl Fatigue Inventory (MFI-20); Multidimensionl Fatigue Inventory (MFI-20) | Multidimensionl Fatigue Inventory (MFI-20); Brief Pain Inventory (BPI) - Intensity of pain (Numeric Rating Scale, NRS); Brief Pain Inventory (BPI) - Intensity of pain (Numeric Rating Scale, NRS); Brief Pain Inventory (BPI) - Intensity of pain (Numeric Rating S |
| NCT06042751 | Randomized Comparison of a Telemedicine-supported Psychosomatic Intervention, a Physical Activity Intervention and the Combination of Both in Patients With Post-covid19 Syndrom. | ACTIVE_NOT_RECRUITING | nan | Hannover Medical School | Fatigue | Health-related quality of life; Depression and Anxiety; Physical and psychological fatigue severity; Post-exertional malaise; Multidimensional Fatigue Inventory; Disability; Work ability; Illness Perception |
| NCT06968104 | Stimulation of the Transcutaneous Auricular Vagus Nerve for Improvement of Symptoms in Patients With Post-COVID Syndrome and ME/CFS | ACTIVE_NOT_RECRUITING | nan | University of Luxembourg | Fatigue | Patient Health (Quality of life); Patient Health (Ability); Post-Exertional Malaise (PEM); Autonomic Function; Sleep Quality; Sleepiness; Depression and Anxiety; Patients Activity |
| NCT07298005 | SON4PEM Study: Sonlicromanol in Post-COVID: A Randomized, Double-blind, Placebo-controlled, Phase II Trial | RECRUITING | PHASE2 | Michele van Vugt | Fatigue | Muscle strength; Cognitive function; Health related quality of life; Fatigue |
| NCT07316127 | A Placebo-Controlled, Double-Blind, Randomized Trial Phase I-II With Immunoadsorption in Autoimmune Long COVID | RECRUITING | PHASE2 | Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) | Change in fatigue measured by the Fatigue Assessment Scale (FAS) | Change in health related quality of life using the 36-Item Short Form Health Survey (SF-36); Change in cognitive functioning using the Patient-Reported Outcomes Measurement Information System (PROMIS®) Cognitive Function Short Form 8a (PROMIS Cognitive Functio |
| NCT05791812 | Application of Direct Current Transcranial stImulation, Remotely superVised in Chronic fATiguE - Heimanwendung Der Transkraniellen Gleichstromstimulation Zur Behandlung Der Chronis | ACTIVE_NOT_RECRUITING | nan | University of Regensburg | Usability for the patients; Usability for the handlers/clinicians; Number of days out of 30 the patients used the device; Number of patients who completed the treatment regularly; Number of responders according the the clinical global impression change score f | Major Depression Inventory; World Health Organisation Quality of life scale (abbreviated Version) (WHOQOL-BREF); Clinical Global Impression change; Pittsburgh sleep quality index; numeric analogue scale pain; d2 test; digital span; Chalder fatigue scale; Bell |
| NCT06251518 | Investigating the Effectiveness of Vimida, a Digital Intervention for People Suffering From Post-viral Chronic Fatigue After COVID-19 Infection | ACTIVE_NOT_RECRUITING | nan | Gaia AG | Fatigue symptom severity | Depressive symptoms; Health-related quality of life; Functioning; Somatic symptoms; Anxiety |
| NCT07374562 | Effect of Stellate Ganglion Block Treatment on Long COVID Symptoms: A Single-Blind, Single-Center Randomized Controlled Trial (STAR-CO) | RECRUITING | nan | Centre intégré universitaire de santé et de services sociaux de la Mauricie-et-du-Centre-du-Québec | Post-COVID-19 Functional Status Scale (PCFS); Fatigue Severity Scale (FSS); Brain Fog Scale (BFS) | Health-Related Quality of Life (SF-36); Dyspnea Severity (mMRC Scale); Lower-Limb Muscle Endurance (1-Minute Sit-to-Stand Test); Orthostatic Intolerance (NASA Lean Test) |
| NCT06170645 | Transcutaneous Vagus Nerve Stimulation as a Complementary Therapy to Exercise in Chronic Fatigue: Single-center, Controlled, Randomized, Blinded Study | RECRUITING | nan | Centre Hospitalier Universitaire de Saint Etienne | Fatigue evaluation assessed by autonomic nervous system activity | Fatigue Severity Scale (FSS); Medical Outcome Study Short Form questionnaire (MOS-SF 12); Pittsburgh questionnaire; 6-minute walk test (6MWT); Adult Physical Activity Questionnaire (APAQ); Step count per day; Ratio of Low Frequency to High Frequency (LF/HF) |
| NCT06865222 | Variable Pulse Transcranial Magnetic Stimulation for Treatment of Post COVID Syndrome | RECRUITING | nan | Mayo Clinic | Change in University of Pennsylvania Smell Identification Test (UPSIT) Olfactory Threshold Test score; Change in Tinnitus Handicap Inventory Scale score; Change in Modified Fatigue Impact Scale score | Change in General Anxiety Disorder-7 (GAD-7) score; Change in Patient Health Questionnaire-9 score; Change in PROMIS Global-10 score; Change in alpha wave characteristics measured via EEG.; Number of serious adverse events (SAEs) |
| NCT06178952 | Transcranial Pulse Stimulation (TPS) in Post-COVID-19 | RECRUITING | nan | Medical University of Vienna | Fatigue Impact Scale (FIS) | Beck Depression Inventory (BDI-II); Montreal Cognitive Assessment (MOCA); 36-Item Short Form Health Survey (SF-36); Trail Making Test A and B (TMT-A and TMT-B); Positive and Negative Affect Schedule (PANAS); Beck Anxiety Inventory (BAI); Six Minute Walking Tes |
| NCT07278388 | Motivated Decision-Making and Performance | RECRUITING | nan | Hugo W. Moser Research Institute at Kennedy Krieger, Inc. | Comparison between PASC and HC - difference in mean Assessment Error; Comparing between PASC and HC - difference in BBB permeability; Comparing between PASC and HC - Regions of the brain that are sensitive to Assessment error as a function of disease state; Th | nan |
| NCT05977179 | A Diet Intervention Study To Mitigate Fatigue Symptoms And To Improve Muscle And Physical Function In Older Adults With Post-Acute COVID-19 Syndrome | RECRUITING | nan | University of Maryland, Baltimore | Fatigue; Physical Function | nan |
| NCT07285473 | Low-dose Naltrexone (LDN) for the Treatment of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS): Dose-Finding | NOT_YET_RECRUITING | PHASE2 | University of Alabama at Birmingham | PROMIS Fatigue Short Form 7a | nan |
| NCT05863897 | e-COGRAT: A Blended eHealth Intervention for Fatigue Following Acquired Brain Injury | ENROLLING_BY_INVITATION | nan | Universiteit Leiden | Daily fatigue | Fatigue after ABI; Fatigue in the general population; Emotional distress; Level of participation; Feasibility of the overall online intervention; Feasibility of each specific online session |
| NCT06522750 | Pilot Study on the Feasibility of an RCT: Evaluating Periodic Fasting as a Treatment Strategy for Long Covid in Adults | RECRUITING | nan | University of Luxembourg | Nutritional protocol; Fatigue assessment Scale (FAS); Quality of Life (WHOQOL); Functionality (WHODAS 2.0); Anxiety (GAD-7); Depression (PHQ-9); Mood States; Blood preasure | Urine Metabolomics; Gut Microbiome; Stool Metabolomics; Blood cytokines; Blood Mitochondrial dysfunction; Blood Epigenetics; Blood test |
| NCT05168124 | Study to Determine the Effectiveness of Therapy Methods (acceptance Commitment Therapy, Micro Breaks) in Patients with Chronic Fatigue Syndrome/ Myalgic Encephalomyelitis | RECRUITING | nan | Sarah Schiebler | Fatigue Severity Scale (FSS) | nan |
| NCT07320937 | Effects of Yiqi Fuyuan Paste Formula in Chronic Fatigue Syndrome: A Randomized Double-Blind Controlled Clinical Trial. | ENROLLING_BY_INVITATION | nan | ShuGuang Hospital | FAI (Fatigue Assessment Instrument) | SF-36 (The MOS 36-Item Short-Form Health Survey); QDC（Qi deficiency constitution score） |
| NCT03773003 | Pathophysiology of Cancer Related Fatigue (CRF) and Chronic Fatigue (CFS/ME) by Lipidomics, Metabolomics, Microbiome and Exome Analysis and Investigation of Clinical Improvement Un | RECRUITING | nan | Universität des Saarlandes | Improvement of fatigue symptoms | nan |
| NCT07278206 | Mitigating Cognitive Problems and Fatigue With Brain Stimulation in Long COVID | RECRUITING | nan | Amsterdam UMC, location VUmc | Fatigue | Objective cognitive functioning; Arterial Spin Labeling (ASL); Magnetic Resonance Spectroscopy (MRS); Functional Magnetic Resonance Imaging (fMRI); Actigraphy; Short physical performance battery (SPPB); Simple Reaction Time (SRT); Effort-based decision task; N |
| NCT06147050 | Pilot Study of an Adaptive, Double-blind, Randomized, Placebo-controlled Study to Evaluate the Effect of Metformin in Reducing Fatigue in Long COVID Adolescent Patients With Chroni | UNKNOWN | PHASE3 | Purpose Life Sciences | Mean Pediatric Quality of Life Multidimensional Fatigue Scale (PedsQL-MFS) score at 90 days post-randomization | Mean PedsQL-MFS score at 30 days post-randomization; Mean PedsQL-MFS score at 60 days post-randomization; Mean Chalder Fatigue Scale (CFS) score at 30 days post-randomization; Mean CFS score at 60 days post-randomization; Mean CFS score at 90 days post-randomi |
| NCT06292377 | Better Understanding of Fatigue After STroke | RECRUITING | nan | Brugmann University Hospital | Heart rate variability (HRV); Heart rate variability (HRV); Heart rate variability (HRV); Transthoracic echography (TTE); Transthoracic echography (TTE); Transthoracic echography (TTE); Fatigue Severity Scale (FSS-7); Fatigue Severity Scale (FSS-7); N-terminal | Blood CRP level; Blood neutrophil-to-lymphocyte ratio (NLR); Stroke localization in the brain; Fazekas scale; Global cortical atrophy scale; Informant Questionnaire on Cognitive Decline in the Elderly (IQCODE); Presence for pre-existing fatigue (yes/no); Durat |
| NCT07009691 | Heart Rate Variability as an Autonomic Marker of Improvement in ME/CFS in a Hydrogen Water Treatment Study | RECRUITING | nan | Stony Brook University | Fatigue Severity Scale | nan |
| NCT05890599 | Randomized Multicenter Clinical Trial: Yoga Versus Health Education for the Treatment of Persistent Fatigue in Patients With Post COVID-19 Syndrome | RECRUITING | nan | University Hospital Tuebingen | Fatigue | Fatigue; Health related quality of life SF-12; Health related quality of life SF-12; Health related quality of life EQ-5D-5L; Health related quality of life EQ-5D-5L; Psychological symptoms; Psychological symptoms; Sleep quality; Sleep quality; Stress; Stress; |
| NCT05931497 | A Pilot Study of Whole Body Hyperthermia for Long Covid or Post-Acute Sequelae of COVID-19 (PASC) | RECRUITING | nan | Massachusetts General Hospital | The Patient Reported Outcome Measurement Information System Fatigue-Short Form v1.0 -Fatigue 7a (PROMIS F-SF) | Patient-Reported Outcomes Measurement Information System (PROMIS-29); Patient Health Questionnaire-9 (PHQ); The Perceived Stress Scale (PSS); Patient-Reported Outcomes Measurement Information System Cognitive Abilities; Patient-Reported Outcomes Measurement In |
| NCT06585254 | Use of Transcutaneous Vagus Nerve Stimulation in Reducing the Symptoms of Long COVID Patients Who Fulfill Diagnostic Criteria for ME/CFS | RECRUITING | nan | Icahn School of Medicine at Mount Sinai | The Chalder Fatigue Questionnaire (CFQ); Change in Short Form Health Survey (SF-36); Visual Analog Scale (VAS) measuring Fatigue; VAS to measure Widespread Pain; VAS measuring Postexertional malaise (PEM); VAS measuring brain fog; Global Clinical Assessment of | Heart Rate Variability (HRV) |
| NCT07546539 | The Role of Photobiomodulation in Patients With Chronic Fatigue Syndrome | NOT_YET_RECRUITING | nan | University of Lahore | Fatigue Improvement | Health Related Quality of Life; Functional Capacity; Pain Intensity; Sleep Quality; Psychological Well-Being; Sustained Effects; Safety and Tolerability; Adverse Effects and Safety Profile |
| NCT05899595 | Effects of a Personalized Physical Training to Reduce Fatigue in Chronic Fatigue Patients: a Randomized Controlled Trial. | TERMINATED | nan | Centre Hospitalier Universitaire de Saint Etienne | The primary outcome is the change in the FACIT-F score obtained before and after the exercise procedure. | nan |
| NCT06510985 | Transcutaneous Vagus Nerve Stimulation (tVNS) for Improved Recovery After Exertion in Patients With Long/Post-COVID. | NOT_YET_RECRUITING | nan | University Hospital Tuebingen | Stimulation-induced changes in invigoration: frequency of button presses during the first seconds of the trial to gain monetary rewards in the Effort Allocation Task.; Stimulation-induced changes in symptoms of depression; Stimulation-induced changes in physic | Stimulation-induced changes in heart rate variability; Stimulation-induced changes in physical activity; Stimulation-induced changes in wanting the monetary rewards; Stimulation-induced changes in exertion; Stimulation-induced changes in the motivation to inve |
| NCT05684952 | The Efficacy and Safety of a Chinese Herbal Medicine (Shenlingcao Oral Liquid) for Treating Long COVID Associated Fatigue：a Double-blinded, Placebo-controlled, Randomized Clinical | UNKNOWN | PHASE2 | Hong Kong Baptist University | Fatigue: Change of scores in Chalder fatigue scale (0-33 points) | Insomnia: Change of scores in Insomnia Severity Index (ISI); Quality of life: Change of scores in 36-Item Short Form Survey (SF-36); Mood: Change of scores in The Hospital Anxiety and Depression Scale (HADS); Muscle strength: Change of Hand Grip Strength (HGS) |
| NCT05667077 | The Effect of Amantadine on Post-COVD-19 Fatigue: a Clinical Trial | UNKNOWN | PHASE2 | Shahid Beheshti University of Medical Sciences | Fatigue Severity Scale (FSS); Visual Analog Fatigue Scale (VAFS) | nan |
| NCT05582603 | Detailed Study on the Safety, Dosage and Feasibility of an Intervention Based on a Computerized Cognitive Training (CCT) for Individuals With Post-acute Sequelae of COVID-19 (PASC) | UNKNOWN | PHASE1; PHASE2 | Universidad Antonio de Nebrija | Fatigue Level Questionnaire; Fatigue Level Questionnaire; Safety Level Questionnaire; Safety Level Questionnaire; Classification of side effect or adverse events; Classification of side effect or adverse events | Computerized Cognitive Assessment; Quality of Life Assessment; Paper-and-pencil Cognitive Assessment |
| NCT05693064 | The Impact of Chiropractic on Fatigue & the Autonomic Nervous System in Adults With Long COVID-19: a Waitlist-controlled, Single-blind, One-way Crossover, Pilot Trial | SUSPENDED | nan | Life University | FACIT fatigue scale; FACIT fatigue scale; FACIT fatigue scale; FACIT fatigue scale; FACIT fatigue scale; FACIT fatigue scale | EEG resting state broadband power; EEG resting state broadband power; EEG resting state broadband power; EEG resting state broadband power; EEG resting state broadband power; EEG resting state functional connectivity; EEG resting state functional connectivity; |
| NCT06386133 | Chronic Fatigue in Multiple Sclerosis: Validating Clinical Performance, Economic, and Organizational Benefits of MSCopilot Boost Compared to Standard Care | NOT_YET_RECRUITING | nan | Ad scientiam | To demonstrate that MSCopilot Boost is superior to standard practice in reducing the impact of fatigue on Patients with Multiple Sclerosis | To evaluate the impact of fatigue in both groups.; To compare the effect of MSCopilot Boost in reducing fatigue impact compared to standard practice (Short term and Medium term); To compare the fatigue impact between the two groups.; To compare the effect of M |
| NCT ID | Title | Status | Phase | Sponsor | Primary endpoint | Secondary endpoint |
|---|---|---|---|---|---|---|
| NCT05999435 | A DOUBLE-BLIND, RANDOMIZED, PLACEBO-CONTROLLED, ADAPTIVE PHASE 2/3 STUDY OF THE EFFICACY OF LAU-7b IN THE TREATMENT OF ADULTS WITH LONG COVID AND MODERATE TO SEVERE SYMPTOMS | COMPLETED | PHASE2; PHASE3 | Laurent Pharmaceuticals Inc. | Change From Baseline in Physical Component Summary (PCS) of the Medical Outcomes Study Short-Form-36 (SF-36) at Week 12 | Safety of LAU-7b, Overview; Patient Global Impression of Change (PGI-C); Proportion of Participants With Marked Improvement in PGI-C; Change From Baseline in the Functional Assessment of Chronic Illness Therapy Fatigue (FACIT-F) Scale; Change From Baseline in |
| NCT05633407 | A Phase 2 Randomized, Double-blinded, Placebo-controlled Study to Evaluate the Efficacy and Safety of Efgartigimod IV in Adult Patients With Post-COVID-19 Postural Orthostatic Tach | COMPLETED | PHASE2 | argenx | Change From Baseline to Week 24 in the COMPASS 31 (2-week Recall Version); Change From Baseline to Week 24 in the MaPS; Number of Participants With TEAEs and TESAEs | Percentage of Participants With Improved PGI-S at Week 24; Percentage of Participants With Improved in PGI-C at Week 24; Change From Baseline to Week 24 in the PROMIS Fatigue Short Form 8a; Change From Baseline to Week 24 in the PROMIS Cognitive Function Short |
| NCT05592418 | A Randomized, Double Blind, Placebo Controlled Study to Evaluate the Efficacy and Safety of Ampligen® in Patients With Post-COVID Conditions | COMPLETED | PHASE2 | AIM ImmunoTech Inc. | Change From Baseline to Week 13 in PROMIS Fatigue Score (T-Score) | Change From Baseline to Week 6 in PROMIS Fatigue Score (T-Score); Change From Baseline to Week 13 in PROMIS Fatigue Score (T-Score), Excluding Response to Item Seven; Change From Baseline to Week 6 and Week 13 in Distance Traveled During 6-minute Walk Test (6M |
| NCT05576662 | Selective Trial Of Paxlovid for PASC (STOP-PASC): Randomized Double-Blind Placebo-Controlled Pilot Trial of Paxlovid for the Treatment of PASC | COMPLETED | PHASE2 | Stanford University | Number of Participants With No, Mild, Moderate, or Severe Symptoms at Week 10 According to the Core Symptoms Severity Scale Score | Number of Participants With No, Mild, Moderate, or Severe Symptoms at Day 15 According to the Core Symptoms Severity Scale Score; Number of Participants Reporting Relief of at Least One Core Symptom for 2 Weeks; Number of Participants With Overall Alleviation |
| NCT04141696 | A Proof-of-Concept Trial on the Effect of Ketamine on Fatigue | COMPLETED | PHASE1; PHASE2 | National Institute of Nursing Research (NINR) | Percentage Change in Self-reported Fatigue Visual Analog Scale (VAS) Scale | Percentage Change in Self-reported Fatigue Visual Analog Scale (VAS) Scale - Day 7; Areas Under the Curve (AUC) for Percentage Changes in Self-reported Fatigue VAS Score - Through Day 7; Mean Physical Activity Count Using Actigraphy; Fatigue Level Measured by |
| NCT03674541 | The Exercise Response to Pharmacologic Cholinergic Stimulation in Myalgic Encephalomyelitis / Chronic Fatigue Syndrome | COMPLETED | PHASE2 | Brigham and Women's Hospital | Change in Peak Oxygen Uptake (Peak VO2) Between the First and Second iCPET | Peak-Rest Oxygen Uptake (VO2); Peak Cardiac Output (Qc); Peak-Rest Cardiac Output (Qc); Peak Right Atrial Pressure (RAP); Peak-Rest Right Atrial Pressure (RAP); Peak Pulmonary Arterial Wedge Pressure (PAWP); Peak Stroke Volume (SV); Peak (Ca-vO2)/[Hgb]; Ventil |
| NCT05126563 | A Randomized, Double-blinded, Single-center, Phase 2 Efficacy, and Safety Study of Allogeneic HB-adMSCs for the Treatment of Patients With Chronic Post-COVID-19 Syndrome. | COMPLETED | PHASE2 | Hope Biosciences Research Foundation | Changes From Baseline in Visual Analog Scale of Neurological Symptoms. - Extreme Fatigue (ANCOVA Model); Changes From Baseline in Visual Analog Scale of Neurological Symptoms.. - Brain Fog (ANCOVA Model); Changes From Baseline in Visual Analog Scale of Neurolo | Changes From Baseline in Visual Analog Scale of Non-Neurological Symptoms. - Dyspnea at Rest (ANCOVA Model); Changes From Baseline in Visual Analog Scale of Non-Neurological Symptoms. - Dyspnea During Activity (ANCOVA Model); Changes From Baseline in Visual An |
| NCT05472090 | A Phase 2, 14-week Double-Blind, Randomized, Multicenter, Placebo-Controlled Study to Evaluate the Efficacy and Safety of TNX-102 SL Taken Daily at Bedtime in Patients With Multisi | COMPLETED | PHASE2 | Tonix Pharmaceuticals, Inc. | Daily Diary Pain NRS | Daily Diary Sleep Quality NRS; PROMIS Fatigue -Short Form 8a; PROMIS Cognitive Function - Abilities-Short Form 8a |
| NCT05445427 | Outcomes of Treatment With Vagal Nerve Stimulation in Post-COVID Syndrome: A Pilot Study | COMPLETED | nan | Mayo Clinic | Change in Post-COVID Functional Status Score | Change in PROMIS Fatigue Scale T Score |
| NCT05200858 | Transcutaneous Electrical Nerve Stimulation For Lower Extremity In Patients With Neurogenic Pain - A Proof Of Concept Randomized Clinical Trial | COMPLETED | nan | Baylor College of Medicine | Mean Change in Functional Interference From Pain From Baseline to 4 Weeks (Blinded Phase) | Mean Change in Pain Severity From Baseline to 4 Weeks (Blinded Phase); Mean Change in Functional Interference From Fatigue From Baseline to 4 Weeks (Blinded Phase); Stride Time at 4 Weeks During a Simple Walking Task (Blinded Phase); Cadence at 4 Weeks During |
| NCT04938687 | Pilot, Effect of Respiratory-Gated Auricular Vagal Afferent Nerve Stimulation (RAVANS) on Post-Treatment Lyme Disease Syndrome | COMPLETED | nan | Spaulding Rehabilitation Hospital | Horowitz Lyme-Multiple Systemic Infectious Disease Syndrome Questionnaire | Sedentary Behaviors Questionnaire; Fatigue Symptom Inventory; Brief Pain Inventory-Pain 24 Hours; Beck Depression Inventory; Beck Anxiety Inventory; Pittsburgh Sleep Quality Index; Timed Up and Go; Time to Complete 4 Meters at Usual Walking Speed,; NIH Toolbox |
| NCT05918978 | Open-Label Extension Study to Evaluate the Long-term Safety and Efficacy of Efgartigimod in Adult Patients With Post-COVID-19 Postural Orthostatic Tachycardia Syndrome (PC-POTS) Wh | TERMINATED | PHASE2 | argenx | Number of Participants With TEAEs, TESAEs and TEAESIs | Change From Baseline to Weeks 24 and 48 in the COMPASS 31 (2-week Recall Version); Change From Baseline to Weeks 24 and 48 in the MaPS; Percentage of Participants With Improved PGI-S at Weeks 24 and 48; Percentage of Participants With Improved PGI-C at Weeks 2 |
| NCT05513560 | REcovering From COVID-19 Lingering Symptoms Adaptive Integrative Medicine (RECLAIM) | COMPLETED | PHASE2; PHASE3 | University Health Network, Toronto | SF-36 physical component score (PCS) | Symptoms scale; Symptom Checklist; Six Minute Walking Test (6MWT) with oximetry; TestMyBrain cognitive testing; Post COVID19 functional status scale; Reintegration to Normal Living Index (RNLI); Fatigue Scale; Brief Fatigue inventory; Post-Exertional Malaise; |
| NCT05939622 | Prospective Randomized Double Blind Placebo Controlled Study of Efficacy of the Therapy With BRAINMAX® Using Functional Magnetic Resonance Imaging (fMRI) for the Treatment of Patie | COMPLETED | PHASE4 | Promomed, LLC | Changing patterns of brain activation using task fMRI with a cognitive paradigm | Asthenia on a scale Multidimensional Fatigue Inventory (MFI-20) after the completion of the parenteral therapy; Fatigue on a Fatigue Assessment Scale (FAS-10) scale after the completion of the parenteral therapy; Cognitive function on a Montreal Cognitive Asse |
| NCT05890534 | Pycnogenol® in People With Post-COVID-19 Condition: a Quadruple-blind, Randomized, Placebo-controlled Trial | COMPLETED | PHASE3 | University of Zurich | Health status (EQ-VAS) | Post COVID-19 symptoms; Fatigue; Dyspnea; Cognitive function; Anxiety and depression; Health-related quality of life (EQ-5D-5L); Functional exercise capacity; Physical activity; Soluble Thrombomodulin (sTM); von Willebrand Factor antigen (VWF:Ag); Syndecan-1; |
| NCT05121766 | Feasibility Pilot Clinical Trial of Omega-3 (EPA+DHA) Supplement vs. Placebo for Post-Acute Sequelae of Coronavirus-19 (COVID-19) Recovery Among Health Care Workers | TERMINATED | PHASE1 | Hackensack Meridian Health | Feasibility Study for Omega-3 Fatty Acid Supplementation v. Placebo in Adult Patients to Limit Long Covid Syndrome - Compliance as Captured by the Number of Participants Who Remain Compliant for the Whole Duration of the Study by Taking All Pills Daily; Feasib | Impact of Omega-3 Supplement on Post-covid Symptoms - Shortness of Breath; Impact of Omega-3 Supplement on Post-covid Symptoms - Cough; Impact of Omega-3 Supplement on Post-covid Symptoms - Fatigue; Impact of Omega-3 Supplement on Post-covid Symptoms - Loss of |
| NCT06128967 | An Adaptive, Randomized, doublE-blind, Placebo-controlled, Prospective, Pharmacological interVention Study In Participants With Long COVID-19 Syndrome: REVIVE-TOGETHER Trial | COMPLETED | PHASE3 | Cardresearch | Improvement on Fatigue Severity Score Scale (FSS) | Improvement on Fatigue Severity Score Scale (FSS); Improvement on Fatigue Severity Score Scale (FSS); Reduction on any cause hospitalization; Safety of metformin; Safety of Fluvoxamine; Death of any cause |
| NCT06404112 | RECOVER-SLEEP: A Platform Protocol for Evaluation of Interventions for Sleep Disturbances in Post-Acute Sequelae of SARS-CoV-2 Infection (PASC) | COMPLETED | PHASE2 | Duke University | Change in total score of the PROMIS 8b SD to assess sleep disturbance; Change in sleep onset variability, assessed using a wearable device | Change in total score of the PROMIS 8a SRI to assess sleep-related impairment; Change in PROMIS 10a Fatigue score; Change in an objective neurocognitive battery score; Change in ECog2 measure; Change in PASC Symptom Questionnaire responses; Change in total sco |
| NCT04997395 | Safety and Tolerability of Full Spectrum Cannabidiol Dominant Medicinal Cannabis in Treating Symptoms Associated With Long COVID: A Feasibility Study | COMPLETED | PHASE2 | Bod Australia | Recruitment rate; Tolerability for the treatment of long COVID; Number of side effects | Long COVID symptoms; Fatigue; Self-reported quality of life; Pain score; Mood (anxiety); Mood (depression); Sleep quality; Resting heart rate (expressed as average beats per minute); Activity levels (number of daily steps, distance walked, stairs climbed, acti |
| NCT05682560 | A Randomized Controlled Phase IIa, Two-arm Study to Assess the Safety and Efficacy of Human Umbilical Cord Blood (RegeneCyte) Infusion in Patients with Post-COVID Syndrome | COMPLETED | PHASE2 | StemCyte, Inc. | Treatment-emergent adverse events (TEAEs) | Change of fatigue score as measured by CFQ-11 |
| NCT05668091 | An Interventional Decentralized Phase 2, Randomized, Double-Blind, 2-Arm Study to Investigate the Efficacy and Safety of Orally Administered Nirmatrelvir/Ritonavir Compared with Pl | COMPLETED | PHASE2 | Harlan M Krumholz | National Institutes of Health (NIH) Patient-Reported Outcomes Measurement Information System (PROMIS)-29 version 2.1 Physical Health Summary Score | Modified General Symptom Questionnaire-30 (Modified GSQ-30); PROMIS® Cognitive Function v.2.0 - Short Form 6a; COVID Core Outcome Measure for Recovery; EuroQol EQ-5D-5L Utility Score-VAS (USA Version); Functional Assessment of Chronic Illness Therapy (FACIT)-I |
| NCT06404099 | RECOVER-SLEEP: A Platform Protocol for Evaluation of Interventions for Sleep Disturbances in Post-Acute Sequelae of SARS-CoV-2 Infection (PASC) | COMPLETED | PHASE2 | Duke University | Change in total score of the PROMIS 8a SRI to assess sleep-related impairment | Change in total score of the PROMIS 8b SD to assess sleep disturbance; Change in PROMIS 10a Fatigue score; Change in an objective neurocognitive battery score; Change in ECog2 measure; Change in PASC Symptom Questionnaire responses; Change in total score on th |
| NCT05823896 | An Interventional, Double-Blinded, 2-Arm Study to Investigate the Efficacy of Orally Administered Nirmatrelvir/Ritonavir Compared with Placebo/Ritonavir in Non-hospitalized Adult P | COMPLETED | PHASE2 | Karolinska Institutet | Change from baseline in quality of life over time | Change from baseline in quality of life over time; Change from baseline in hemodynamic response over time; Change from baseline in dysautonomia over time; Change from baseline in fever in patients with POTS over time; Change from baseline in endothelial functi |
| NCT05152849 | A Randomized, Double-Blind, Placebo-Controlled Pilot Study to Evaluate the Efficacy, Safety, and Tolerability of AXA1125 in Subjects With Fatigue-Predominant Post-Acute Sequelae of | COMPLETED | PHASE2 | Axcella Health, Inc | Change from baseline at Week 4 in the phosphocreatine (PCr) recovery rate following moderate exercise, as assessed by 31P-magnetic resonance spectroscopy (MRS) | Change from baseline in PCr recovery rate as assessed by phosphorus magnetic resonance spectroscopy (31P-MRS); Proportion of subjects with improvement in PCr recovery rate; Change from baseline in serum lactate level after a 6-minute walk test; Proportion of s |
| NCT05228899 | A Phase I/II Multicenter, Randomized, Double Blinded, Placebo Trial to Evaluate the Safety and Potential Efficacy of Zofin Infused Intravenous (IV) in Patients Experiencing Prolong | COMPLETED | PHASE1; PHASE2 | ZEO ScientifiX, Inc. | Incidence of Severe Adverse Events | Fatigue Severity Score Score; Daily Diary of COVID-19 Related Symptom; COVID-19 Associated Symptoms Length; COVID-19 Associated Symptoms Mitigation; Beck Depression Inventory Score; Mental Fatigue Questionnaire Score; Pulse Oxygen Saturation; Heart Rate Variab |
| NCT05497089 | Temelimab as a Disease Modifying Therapy in Patients With Neurological, Neuropsychological, and Psychiatric (=Neuropsychiatric) Symptoms in Post-COVID 19 or Postacute Sequelae of C | COMPLETED | PHASE2 | GeNeuro SA | Improvement in fatigue in PASC patients | Fatigue; Cognitive function; Cognitive function; Cognitive function; Cognitive function; Anxiety; Depression; Overall quality of Life; Functional impairment; Post-COVID-19 Functional Status; Safety and tolerability of Temelimab in PASC patients |
| NCT04944121 | A Phase 2, Double-blind, Placebo-controlled Study of RSLV-132 in Subjects With Post-acute COVID-19 (Long COVID) | COMPLETED | PHASE2 | Resolve Therapeutics | PROMIS Fatigue SF 7a T-score | FACIT Fatigue questionnaire; Long COVID-19-related Symptom Assessment patient questionnaire; Patient-reported Global Impression of Severity questionnaire; Digit Symbol Substitution Test; Physician Global Assessment |
| NCT05299333 | Comparison of the Effectiveness of Pulmonary Telerehabilitation and Physical Activity Recommendations in Patients With Pulmonary Fibrosis Due to COVID-19 | COMPLETED | nan | Istanbul University - Cerrahpasa | Submaximal exercise capacity; maximal exercise capacity; endurance exercise capacity; Peripheral muscle strength | Physical activity; Dyspnea; Fatigue; Physical fitness; Functionality; System usability; Emotional status; Body composition; Activities of daily living |
| NCT05679505 | Effects of Vagus Nerve Stimulation in Post-COVID-19 Syndrome: A Randomized Controlled Trial | COMPLETED | nan | Bahçeşehir University | Heart Rate Variability | Fatigue Severity Scale |
| NCT06974058 | Evaluation of a Quercetin/Curcumin-Based Supplement for Mild to Moderate Long COVID-19 Symptoms: A Pragmatic, Interventional Clinical Study. | COMPLETED | nan | Liaquat University of Medical & Health Sciences | Change in Overall Symptom Burden | Change in Functional Status and Quality of Life (SF-36 Scores); Change in the Need for Prescribed Medications or NSAIDs (Non-Steroidal Anti-Inflammatory Drugs); Change in Pain Severity and Pain Interference (Brief Pain Inventory - Short Form); Change in Fatigu |
| NCT05119634 | The Effect of Whole Body Vibration Training in Individuals With Post COVID - 19 | COMPLETED | nan | Istanbul University - Cerrahpasa | 6 minutes walking test; 6 minutes pegboard and ring test; International Physical Activity Form (IPAQ); activity monitoring with Actigraf GT3X; peripheral muscle strength measurement; pulmonary function test | Post-COVID-19 Functional Status Scale; Chalder Fatigue Questionnaire; Clinical Frailty Scale; EuroQol- 5 Dimension; Hospital Anxiety and Depression Scale (HADS); Impact of Events Scale (IES-R); Pittsburgh Sleep Quality Index (PSQI); static posturography device |
| NCT05107440 | BREATHE: A Mixed-methods Evaluation of a Virtual Self-management Program for People Living With Long COVID-19 in Alberta | COMPLETED | nan | University of Calgary | Self-efficacy to manage symptoms; Self-efficacy to manage daily activities; Self-efficacy to manage emotions | Self-efficacy to manage symptoms; Self-efficacy to manage daily activities; Self-efficacy to manage emotions; Fatigue severity (FACIT-F); Fatigue severity (FACIT-F); Medical Research Council (MRC) breathlessness scale grade; Medical Research Council (MRC) brea |
| NCT05857124 | A Pilot Study Evaluating the Efficacy of the Vielight Neuro RX Gamma in the Treatment of Post COVID-19 Cognitive Impairment | COMPLETED | PHASE1 | Vielight Inc. | The change in the combined results of 7 Creyos items: Spatial Planning, Monkey Ladder, Rotations, Feature Match, Paired Associates, Token Search, Polygons. | Creyos scores of the 5 remaining tests (i.e. Grammatical Reasoning, Spatial Span, Digit Span, Odd One Out, Double Trouble); EQ-5D-5L Quality of Life; Fatigue Assessment Scale (FAS); The perceived deficits questionnaire - 20 item version (PDQ-20); Compliance an |
| NCT05703074 | The Efficacy and Safety of a Mental Intervention Program vs. Usual Care and Nicotinamide Riboside (NR) vs. Placebo for Improving Health-related Quality of Life in Long Covid: A 2 x | ACTIVE_NOT_RECRUITING | PHASE2 | University Hospital, Akershus | Health-related quality of life | Inflammation; Executive functioning; Fatigue; Dyspnoea; Global impression of change; Cost-effectiveness |
| NCT06330376 | Diaphragmatic Breathing Exercises for Post-COVID-19 Diaphragmatic Dysfunction (DD) | COMPLETED | nan | University of Minnesota | 6-minute walk test (6MWT) | PHQ9: Patient health questionnaire 9; GAD7: Generalized anxiety disorder 7-item; PROMIS score: Patient-Reported Outcomes Measurement Information System; QoL scale: Quality of life scale; FACIT fatigue scale 's Fatigue score; Modified Borg dyspnea scale; R |
| NCT05024474 | Effects of Inspiratory Muscle Training After Covid-19 | COMPLETED | nan | Karolinska Institutet | Change in Maximal Inspiratory Pressure (MIP) | Change in Maximal Expiratory Pressure (MEP); Change in Lung function; Change in walking distance during 6 minute walk test, expressed as percentage of predictive value,; Change in oxygen saturation during 6 minute walk test; Change in oxygen desaturation durin |
| NCT05196451 | Short-time Behavioural Intervention in Post-Covid Syndrome (SIPCOV): A Pragmatic Randomised Controlled Trial | COMPLETED | nan | University Hospital, Akershus | Physical Functioning | Fatigue; Fatigue; Depression/anxiety; Depression/anxiety; Adverse effects; Adverse effects; Physical Functioning; Recovery from PIFS; Recovery from PIFS |
| NCT05710770 | Double-blinded, Randomized, Sham-controlled Trial of Immunoadsorption (IA) in Patients With Chronic Fatigue Syndrome (CFS) Including Patients With Post-acute COVID-19 CFS (PACS-CFS | COMPLETED | nan | Charite University, Berlin, Germany | Improvement in physical and mental fatigue as measured by the Chalder Fatigue Scale | Sustained improvement quantified by the Chalder Fatigue Scale; Verification of safety and tolerability of immunoadsorption in this patient population; Improvement in severity of symptoms of chronic fatigue syndrome (CFS) as measured by the Fluge score; Improve |
| NCT04308278 | Randomized, Placebo-controlled, Double Blind Study to Evaluate the Efficacy of 2LEBV® and 2LXFS® on Asthenia in Patients With an Epstein-Barr Virus Infection. | RECRUITING | PHASE4 | Labo'Life | Measure of the general fatigue scale of the Multidiensional Fatigue Inventory-20 (MFI-20) questionnaire at the end of the treatment. | Comparison of the efficacy of the treatment on physical fatigue, reduced activity, reduced motivation and mental fatigue scales on the MFI-20 questionnaire between the 2LEBV® or the 2LXFS®/2LEBV® group versus the placebo group; Comparison of the efficacy of th |
| NCT06658340 | Positivity in Post-COVID: Promoting Well-being in Patients with Post-COVID-19 Syndrome - a Feasibility and Acceptability Study | COMPLETED | nan | University of Twente | Feasibility of the intervention exercises; Acceptability of the intervention exercises - willingness to do again; Acceptability of the intervention exercises - satisfaction; Acceptability of the intervention exercises - perceived utility; Acceptability of the | Change in affect; Change in mental well-being; Change in post-COVID symptom severity and functionality; Change in fatigue; Change in anxiety; Change in depression; Change in ability to adapt; Change in perceived illness control; Perceived overall impact |
| NCT05244044 | Changes in Functional Exercise Capacity After PUlmonary REhabilitation in Primary Care: a Randomized, Controlled, Multicenter, Pragmatic Trial in 134 Patients With Long COVID (PuRe | COMPLETED | nan | University Hospital, Antwerp | Exercise capacity | Change in physical activity; Change in COVID-19 related symptoms; Change in quality of life; Change in fatigue; Change in dyspnoea; Change in functional status; Change in work productivity and activity impairment.; Change in anxiety and depression symptoms.; C |
| NCT07280572 | RECLAIM: an Adaptive Platform Trial for the Evaluation of Treatments for Post-Acute Sequelae of SARS-CoV-2 Infection (PASC) | ENROLLING_BY_INVITATION | PHASE3 | Janneke van de Wijgert | Physical health-related quality of life (HRQoL) | Mental HRQoL; Other aspects of HRQoL; Fatigue; Post Exertional Malaise (PEM); Cognitive functioning; Post Orthostatic Tachycardia Syndrome (POTS); Safety of IPs; Tolerability of IPs; Durability of IP treatment responses |
| NCT05699538 | Fatigue and Fatigability in Veterans Following SARS-CoV-2 Infection | COMPLETED | nan | VA Office of Research and Development | Performance fatigability | Rating of Perceived Fatigue (RPF); Isometric and Isokinetic Knee Extensor Torque; Skeletal muscle oxygen extraction; Feeling Scale; Fatigue Severity Scale (FSS); Short Physical Performance Battery (SPPB); 30-second sit-to-stand; Six Minute Walk Test (6MWT); Mo |
| NCT05798221 | Complementary Self-help Strategies for Patients With Post-COVID-19 Syndrome: A Randomized Controlled Trial | COMPLETED | nan | Universität Duisburg-Essen | Post-COVID-19 symptom burden | Post-COVID-19 symptom burden; Post-COVID-19 functional status (self-reported); Post-COVID-19 functional status (self-reported); Health-related quality of life; Health-related quality of life; Fatigue; Fatigue; Anxiety and depression; Anxiety and depression; In |
| NCT04841759 | The Effects of a Multi-factorial Rehabilitation Program for Healthcare Workers Suffering From Post-COVID-19 Fatigue Syndrome | COMPLETED | nan | Medical University of Vienna | Change of maximum oxygen uptake (VO2max) over time-points (baseline - 4 weeks - 8 weeks) assessed during cardio-pulmonary exercise testing (CPET) | Change of walking distance during a six minutes walk test (6MWT) over time-points (baseline - 4 weeks - 8 weeks); Change of numbers over time-points (baseline - 4 weeks - 8 weeks) how often someone can stand up and sit down on a chair within 30 seconds during |
| NCT05697640 | A Parallel-group Treatment, Phase 2a, Double-blind, Placebo-controlled 2-arm Study to Show Improvement of Physical Function in SF-36 (SF-36-PF) in Participants Treated With Vericig | ACTIVE_NOT_RECRUITING | PHASE2 | Charite University, Berlin, Germany | Improvement in Physical Function (PF) as measured by the Short Form 36 Health Survey Questionnaire (SF-36) | Difference in responder rate in Physical Function (PF) as measured by the Short Form 36 Health Survey Questionnaire (SF-36) comparing Vericiguat with placebo; Improvement in other sub-domains of the Short Form 36 Health Survey Questionnaire (SF-36) comparing V |
| NCT04983394 | Effect of Motion-Controlled Video Games-Based Virtual Reality Exercise On Pain, Fatigue, Mood, Functional Capacity, And Quality of Life in Patients With Post-Covid-19 Condition: A | COMPLETED | nan | Cumhuriyet University | visual Analogue Scale | hospital anxiety and depression scale-Depression; hospital anxiety and depression scale-Anxiety; Fatigue severity scale; Short Form-12; 6 minutes walking test |
| NCT06590324 | A Phase II, Multi-centre Open Label Study to Assess the Efficacy and Safety of Oral Apabetalone With Background Dapagliflozin in Subjects With Long -COVID-19 (Post-COVID-19 Conditi | RECRUITING | PHASE2; PHASE3 | Resverlogix Corp | patient acceptable symptom state (PASS) | Long COVID Symptom and Impact tools (LCST/LCIT); Patient-Reported Outcomes Measurement Information System (PROMIS)-Fatigue Short Form 7a (SF-7a); Baseline Dyspnea Index (BDI) & Transition Dyspnea Index (TDI); Post-COVID-19 Functional Status (PCFS) Scale; D |
| NCT06054438 | Examining the Immunomodulatory and Health Improving Function of a Chinese Medicine Nutritional Supplement Cs4 on Immunity-related Disorders in the Post-COVID Era | COMPLETED | nan | The University of Hong Kong | the change in symptom severity from 0 to 12 weeks measured by the modified COVID-19 Yorkshire Rehabilitation Scale (C19-YRSm) | the change in Insomnia Severity Index (ISI) from 0 to 12 weeks; the change in Brief Fatigue Inventory Form (BFI) from 0 to 12 weeks; the change in St. George's Respiratory Questionnaire (SGRQ) from 0 to 12 weeks; the change in Hospital Anxiety and Depress |
| NCT05126511 | Effects of Cranial Electrotherapy Stimulation on Anxiety of Patients After COVID-19 - a Randomised Controlled Pilot Study | COMPLETED | nan | Schön Klinik Berchtesgadener Land | Change of symptoms of anxiety during intervention | Change in insomnia during intervention; Change in fatigue during intervention; Change in depression during intervention; Change of general condition/ perceived well-being of the patient; Subjective effectiveness of device; Comfort while using the device |
| NCT06108297 | Effect of Low-dose Lithium Therapy on Long COVID Symptoms: an Open-label, Dose-finding Study. | COMPLETED | PHASE1 | State University of New York at Buffalo | Fatigue Severity Scale (FSS); Brain Fog Severity Scale (BFSS) | Well Being Scale; Short Form-12 Health Survey; FSS scores in those with FSS score ≥28 at baseline; BFSS scores in those with FSS score ≥28 at baseline; Modified Fatigue Impact Scale; Perceived Deficits Questionnaire, 5-Item Version; Beck Depression Inventory-I |
| NCT06341751 | Psychological Treatment for Persistent Fatigue: a Feasibility Study | COMPLETED | nan | Karolinska Institutet | Treatment adherence and completion; Treatment credibility; Patient satisfaction; Working alliance; Negative effects of treatment; Open-ended questions regarding treatment content and presentation | Feasibility of study inclusion procedures and data-collection; Fatigue severity, primary self-rated symptom outcome; Problems concentrating; Reduced physical activity; Reduced motivation; Depressive symptoms; Somatic symptoms; General anxiety; Insomnia; Percei |
| NCT05532904 | Evaluation and Comparison of Multidisciplinary Day-hospital Versus Waiting List Management of Persistent Symptoms After an Acute Episode of COVID-19 | COMPLETED | nan | Assistance Publique - Hôpitaux de Paris | Quality of life | Quality of life; Fatigue; Dyspnea; Cognitive complaint; Pain; Patient's satisfaction; Physical fitness; Post-effort heart rate; Weight loss; BMI; Blood albumin; Nutritional risk; Health beliefs associated with persistent symptoms |
| NCT07524179 | The Effect of Therapeutic Touch on Sleep Quality and Fatigue Severity in Advanced Cancer Patients in the Palliative Care Setting: A Randomized Controlled Trial | COMPLETED | nan | Erzurum Technical University | Sleep Quality | Fatigue Severity |
| NCT06960928 | Low Dose Sirolimus in People With Post-Acute Sequelae of COVID-19 (PASC) Long COVID-19 | RECRUITING | PHASE3 | Icahn School of Medicine at Mount Sinai | European Quality of Life-Visual Analogue Scale (EQ-VAS) | The EuroQol Five-Dimensional Health Questionnaire (EQ-5D-5L); Patient-Reported Outcomes Measurement Information System 29 (PROMIS-29); General Symptom Questionnaire (GSQ-30); Patient Health Questionnaire (PHQ-9); Generalized Anxiety Disorder (GAD-7); Neuro-QoL |
| NCT05631171 | COVIDAI: Feasibility Study of Adhera® Fatigue Digital Program for Patients With Long COVID-related Fatigue | COMPLETED | nan | Adhera Health, Inc. | Health-related quality of life; Health-related quality of life; Health-related quality of life; Fatigue; Fatigue; Fatigue; Emotional wellness; Emotional wellness; Emotional wellness | Behavioral outcome: Usability; Behavioral outcome: Usability; Fatigue-related symptomatology; Fatigue-related symptomatology; Mood; Mood; Mood; Social, psychological and emotional wellness; Social, psychological and emotional wellness; Social, psychological an |
| NCT06016192 | Medical Rehabilitation of Patients With Long-term Post-Covid-19 Syndrome - a Comparison of Aerobic Interval and Continuous Training | COMPLETED | nan | University of Witten/Herdecke | Change in Cardiorespiratory Fitness (CRF) | Change in Submaximal Cardiorespiratory Fitness (CRF); Change in Fatigue; Work requirements and workload; Change Health-related quality of life; Wellbeing; Change in Depression and Anxiety |
| NCT05003271 | Pulmonary Rehabilitation Post-COVID-19: a Pilot Study | COMPLETED | nan | University of Manitoba | Feasibility of the program; Recruitment rate; Intervention completion rate; Dropout rate; Patient safety; Patient satisfaction with the program | Change in lung capacity; Change in dyspnea; Changes in fatigue severity assessed with the Fatigue Severity Scale; Changes in fatigue assesses with the DePaul Symptom Questionnaire short-form; Change in sit-to-stand capacity; Change in post-exercise saturation; |
| NCT05715554 | Community-based Individualized Homeopathic Rehabilitation in Post COVID-19 Patients: Results of a Pilot, Pragmatic, Randomized, Open Label, Controlled Trial Investigating Acceptabi | COMPLETED | nan | Innowage Limited | Cough severity | Change in dyspnea; Change in Fatigue; change in Quality of Life |
| NCT05254301 | Faster Functional Performance Recovery After Individualized Nutrition Therapy Combined With a Patient-tailored Physical Rehabilitation Program Versus Standard Physiotherapy in Pati | COMPLETED | nan | Universitair Ziekenhuis Brussel | 1-minute sit-to-stand (1-MSTS) | Multi-dimensional Fatigue Inventor (MFI-20); EuroQol five-dimensional (five-level version) (EQ-5D-5L); Post-COVID-19 Functional Status (PCFS); Hospital Anxiety and Depression Scale (HADS); Work Productivity and Activity Impairment (WPAI) |
| NCT04718506 | Rehabilitation for Post-COVID-19 Syndrome Through a Multicomponent, Educational and Supervised Exercise Intervention [RECOVE] | COMPLETED | nan | Universidad de Murcia | Changes in subject clinical status | Changes in cardiovascular fitness: Maximal oxygen consumption (VO2max); Changes in neuromuscular performance during resistance exercise: Barbell Mean Propulsive Velocity (MPV); Changes in balance: center of pressure (COP) sway; Changes in pulmonary function: F |
| NCT05697042 | A Mobile Intervention Merging Yoga and Self-Management Skills (MY-Skills Mobile) for Individuals Experiencing Symptoms of Long COVID-19 | COMPLETED | nan | University of Colorado, Denver | Feasibility- Recruitment; Feasibility- Use; Feasibility- Attrition; Feasibility-Usability | Symptom Burden Scale for Long COVID; PROMIS Fatigue; Brief Pain Inventory; Short Form 36 |
| NCT04158427 | Intestinal Microbiota and Chronic Fatigue Syndrome. Effect of Fecal Transplant on Health Related Quality of Life of the Patients With Chronic Fatigue Syndrome | COMPLETED | nan | Tampere University Hospital | Health related quality of life assessed by EQ-5D-5L questionnaire; Health related quality of life assessed by 15D questionnaire; Health related quality of life assessed by Modified Fatigue Impact Scale; Ability to work or study; Visual Analog Fatigue Scale | Health related quality of life assessed by EQ-5D-5L questionnaire; Health related quality of life assessed by 15D questionnaire; Health related quality of life assessed by Modified Fatigue Impact Scale; Ability to work or study; Visual Analog Fatigue Scale |
| NCT05566379 | Effects of a Mindfulness Intervention on Physical and Psychological Well-Being and Quality of Life in Patients With Post Acute Sequelae of SARS-CoV-2 Infection (PASC) Dysautonomia | COMPLETED | nan | University of California, Los Angeles | Change from baseline in the composite autonomic symptom score COMPASS-31 for autonomic symptoms; Change from baseline in Active Stand Test of hemodynamic symptom parameters, exercise tolerance.; Change from baseline of Six Minute Walk in hemodynamic parameters | Change from baseline in mean scores of PSS- Perceived Stress Scale.; Change from baseline in mean scores of GAD7- Generalized Anxiety Disorder; Change from baseline in mean scores of PHQ-8 - Depressive Symptoms; Change from baseline in mean scores of IES-R - e |
| NCT04900961 | Prevention and Early Treatment of the Long-term Physical Effects of Coronarvirus-19 (COVID-19): a Randomised Clinical Trial of Resistance Exercise. | COMPLETED | nan | NHS Greater Glasgow and Clyde | Incremental Shuttle Walk Test | Spirometry; Handgrip Strength; Short Physical Performance Battery; EuroQol-5 dimension (EQ)-5D; Patient Health Questionnaire-4 (PHQ4); Brief Illness Perception Questionnaire (IPQ); Duke Activity Status Index (DASI); International Physical Activity Questionnair |
| NCT05770193 | Effect Of Kinesio Tape Versus Diaphragmatic Breathing Exercise In Post COVID-19 Patients(A Comparative Study) | COMPLETED | nan | Cairo University | Modified Medical research council | Pulse oximeter; Arabic version of The Fatigue Severity Scale; six-minute walk test; The World Health Organization Quality-of-Life Scale (WHOQOL-BREF). |
| NCT05231512 | The Effects of a Music Therapy Respiratory Protocol on Post-Covid Respiratory Symptoms | COMPLETED | nan | Icahn School of Medicine at Mount Sinai | MRC dyspnea score | Self-reported Chronic Respiratory Questionnaire (CRQ-SR); Visual Analog Scale (VAS); Beck Depression Inventory - short form (BDI-SF); General Anxiety Disorder 7-item questionnaire (GAD-7); Hospital Anxiety and Depression Scale (HADS); Coronavirus Anxiety Scale |
| NCT05954325 | Extracorporal Apheresis Hannover Medical School Study in Post COVID-19 Patients | COMPLETED | nan | Hannover Medical School | Chalder Fatigue Scale | Cognitive Function; Post exertional malaise symptoms; Measure of health status; Depression and Anxiety; Autonomic dysfunction; 6-min. walk test; Hand grip strength; Optical coherence tomography angiography; Cranial magnetic resonance imaging and spectroscopy; |
| NCT06064838 | Effects of Cacao Flavonoids in Long COVID-19 Patients with Chronic Fatigue (FLALOC) | COMPLETED | nan | Guillermo Ceballos Reyes | Interleukin-1b; Interleukin-6; TNF-alpha; Syndecan-1 | EQ-5D questionnaire; Analog Visual Scale; Numerical fatigue rating scale; Handgrip strength |
| NCT05172206 | Symptom-based Rehabilitation Compared to Usual Care in Post-COVID - a Randomized Controlled Trial | COMPLETED | nan | Schön Klinik Berchtesgadener Land | Change from baseline Quality of life assessed by Short Form - 12 Questionnaire at week 4 and week 12 | Change from baseline COVID-related symptoms at week 4 and week 12; Change from baseline lung function at week 4 and week 12; Change from baseline blood gas analysis at week 4 and week 12; Change from baseline Cardiac Doppler echocardiography at week 4 and week |
| NCT05732571 | Post COVID REspiratory Mechanisms and the Efficacy of a Breathing Exercise Intervention for DYsregulated Breathing (REMEDY): COVID-19 | COMPLETED | nan | University of Nottingham | Breathlessness.; Function | Dyspnoea-12 Questionnaire; Nijmegen Questionnaire; Borg Scale of Breathlessness; Four metre Gait speed; Modified Minnesota Physical Activity; Capnography - in some volunteers; Chalder Fatigue Score; EQ5D Quality of Life score; Adherence; Breath hold, Respirato |
| NCT06189066 | Long COVID Ultrasound Trial [LOCUS Trial] | COMPLETED | nan | SecondWave Systems Inc. | Within-arm change in the endurance shuttle walk test (ESWT) from baseline to the completion of an up-to 8-week intervention period. | Within-arm change in the Chalder fatigue scale (CFQ-11; Likert score) from baseline to the completion of an up-to 8-week intervention period.; Track adverse events throughout the study to assess the safety of the ultrasound intervention. |
| NCT05658536 | The COPE Study: Pilot Intervention to Improve Symptom Self-management and Coping in Adults With Post COVID | COMPLETED | nan | University of Washington | Intervention Acceptability; Intervention Appropriateness; Intervention Feasibility | Depressive Symptoms; Anxiety Symptoms; Fatigue; Sleep Disturbance; Perceived Cognitive Difficulties; Self-Efficacy; Psychosocial Functioning; Pain Interference; Impression of Change; Symptoms and Impact of Post-COVID |
| NCT05305105 | Effects of Psilocybin in Post-Treatment Lyme Disease | COMPLETED | PHASE1 | Johns Hopkins University | Change in multi-system symptom burden as assessed by the General Symptom Questionnaire (GSQ-30) score; Change in functional health and well-being as assessed by the Short Health Form (SF-36) score | Change in fatigue as assessed by the Fatigue Severity Scale (FSS) score; Change in pain as assessed by the Short-Form McGill Pain Questionnaire (SF-MPQ) |
| NCT04919031 | Inspiratory Muscle Trainer Impact on Post Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) COVID-19 Hypertensive Patients With Long Term Persistent Symptoms | COMPLETED | nan | Cairo University | maximal inspiratory pressure | sleeping quality scale; Timed stair climbing; 6 minute walk test; modified medical research council (mMRC) scale (0-4); Oxygen saturation; dyspnea borg scale; postural tachycardia syndrome; blood pressure (mmHg); lactate level; fatigue severity scale (0-63); P |
| NCT05894629 | Effects of an Active Coping Program in Patients With Persistent Post-Covid Pain. | COMPLETED | nan | University of Valladolid | Quality of life (QoL) | Pain Intensity; Body Chart; Quantitative sensory tests; Handgrip Strength assessment; 30 sit to stand test; 6 Minute Walking Test (6MWT); Maximal Inspiratory and Expiration Pressure (MIP/MEP); Catastrophism; Anxiety; Depression; Drug consumption.; Fatigue |
| NCT05204511 | Exercise and Post-COVID/Long-COVID: Effects of Different Training Modalities on Physical Performance, Heart Rate Variability, Inflammation, Health-Related Quality of Life, Cognitiv | COMPLETED | nan | University of Vienna | Change of peak oxygen consumption (VO2peak measured in ml/min/kg) | Change of maximum lower body isometric muscle strength (measured in N); Change of maximum hand grip strength (measured in kg); Change of Standard Deviation of RR-Intervals (SDNN measured in ms); Change of Root Mean Square of Successive Differences (RMSSD measu |
| NCT05225220 | Multimodal Investigation of Post COVID-19 in Females: A Pilot Study | COMPLETED | nan | Casa Colina Hospital and Centers for Healthcare | Change in Flanker Inhibitory Control and Attention Test (Flanker) scores; Change in Picture Sequence Memory Test (PSMT) scores; Change in Dimensional Change Card Sort Test (DCCS) scores; Change in Pattern Comparison Processing Speed scores; Change in List Sort | Change in Magnetic Resonance Imaging (MRI); Change in resting state Electroencephalograph (EEG) signals; Change in blood marker levels; Change in BURNS Anxiety Inventory scores; Change in Becks Depression Inventory (BDI) scores; Change in PROMIS Sleep Disturba |
| NCT06492590 | Assessing a Multicomponent Intervention to Improve Quality of Life in Individuals With Long COVID-19 (COVIDL/MIQoL): A Randomized Controlled Trial | COMPLETED | nan | Consorci Sanitari de Terrassa | Improved quality of life | Improve well-being; Decreased anxiety and depression; Increased resilience; Improve physical activity; Decreased fatigue |
| NCT06847191 | A Double-blind, Randomized Study to Evaluate the Efficacy and Safety of Bezisterim (NE3107) in Adults With Long COVID | ACTIVE_NOT_RECRUITING | PHASE2 | BioVie Inc. | Change from Baseline in performance on the Cogstate Cognition battery* | Change from Baseline in PROMIS Cognitive Function Short Form 8a (SF-8a); Change from Baseline in PROMIS Fatigue Short Form 13a (SF-13a); Change from Baseline in PROMIS Sleep Disturbance Short Form 8a (SF-8a); Change from Baseline in SF-12 Health Survey (Physic |
| NCT05752331 | Feasibility of Personalised Health Behaviour Coaching to Support Symptoms and Activities of Daily Living in Those With Long COVID-19. | COMPLETED | nan | Bournemouth University | Participant recruitment; Participant randomisation; Participant completion; Participant acceptability | Objective physical activity; Exercise capacity; Muscular strength and endurance; Lung Function; Health related quality of life; Breathlessness; Fatigue; Anxiety and Depression; Cognitive impairment |
| NCT05846126 | Digital Rehabilitation With Cognitive Training, Physical Activity and Mindfulness for People With Post-acute COVID-19 Syndrome With Cognitive Impairment. REHABCOVID Project. | COMPLETED | nan | Consorci Sanitari de Terrassa | Differences between groups in scores of global cognition; Differences between groups in scores of selective attention, inhibition, and processing speed; Differences between groups in scores of Visual scanning and processing speed; Differences between groups in | Differences between groups in scores of anxiety; Differences between groups in scores of depression; Differences between groups in scores of Mindfulness levels; Differences between groups in scores of Fatigue; Differences between groups in scores of psychologi |
| NCT05956405 | Retraining of the Amygdala and Insula for the Treatment of Persistent Covid | COMPLETED | nan | Hospital Miguel Servet | Short Form de 36 items (SF-36); Short Form de 36 items (SF-36); Short Form de 36 items (SF-36); Short Form de 36 items (SF-36); Short Form de 36 items (SF-36); Short Form de 36 items (SF-36) | Sociodemographic data Gender, age, marital status, education, occupation, economical level; Sociodemographic data Gender, age, marital status, education, occupation, economical level; Spanish Chronic Pain Grading Scale; Spanish Chronic Pain Grading Scale; Span |
| NCT05298878 | Virtual Physical Rehabilitation for Patients Living with Long COVID | COMPLETED | nan | McGill University Health Centre/Research Institute of the McGill University Health Centre | Change in the basic mobility domain of the Activity Measure for Post-Acute Care (AM-PAC) | Change in lower-body strength; Change in functional mobility; Change in fatigue; Change in dyspnea; Change in health-related quality of life; Change in health state utilities; Change in anxiety and depression; Change in cognitive function; Change in the degree |
| NCT04996212 | Study of the Effectiveness of a Cardiorespiratory Telerehabilitation Program in Persistent COVID-19 Patients. Randomized Clinical Trial. | COMPLETED | nan | University of Valencia | Quality of life (EQ-5D-5L) | Quality of life (EQ-5D-5L) Change from Baseline PostCovid-19 Functional Satatus Scale at five months (PCFSS); Fatigue Assessment Scale (FAS); London Chest Activity of Daily Living Scale (LCADL); Hospital Anxiety and Depression Scale (HADS); Perceived Stress Sc |
| NCT05630040 | Vagus Nerve Simulation for Long-COVID-19 | COMPLETED | nan | Icahn School of Medicine at Mount Sinai | Composite Dysautonomia Symptom Score (COMPASS 31); Composite Dysautonomia Symptom Score (COMPASS 31); Composite Dysautonomia Symptom Score (COMPASS 31); Composite Dysautonomia Symptom Score (COMPASS 31); Composite Dysautonomia Symptom Score (COMPASS 31) | Fatigue Severity Scale (FSS); Fatigue Severity Scale (FSS); Fatigue Severity Scale (FSS); Fatigue Severity Scale (FSS); Fatigue Severity Scale (FSS); Neuro Quality of Life Score; Neuro Quality of Life Score; Neuro Quality of Life Score; Neuro Quality of Life S |
| NCT06073002 | Effects of a Home-Based Exercise Intervention on Physical Function, Symptoms and Health-Related Quality of Life in Subjects with Long Covid | ACTIVE_NOT_RECRUITING | nan | University of Vienna | Change of peak oxygen consumption (VO2peak measured in ml/min/kg) | Change of maximum lower body isometric muscle strength (measured in N); Change of maximum hand grip strength (measured in kg); Change of Standard Deviation of RR-Intervals (SDNN measured in ms); Change of Root Mean Square of Successive Differences (RMSSD measu |
| NCT07359482 | sElective Serotonin reuPtake inhibitoRs In posT-covid: ESPRIT | NOT_YET_RECRUITING | PHASE3 | Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) | Fatigue severity | Fatigue severity; Cognitive functioning; Cognitive functioning; PEM; POTS (National Aeronautics and Space Administration (NASA) lean test; POTS; Health-related Quality of Life; Disability; Side effects; Side effects; Brain Perfusion (optional MRI substudy); Br |
| NCT05705193 | Computerized Cognitive Remediation of Long COVID Symptoms in Older Adults | ACTIVE_NOT_RECRUITING | nan | UConn Health | Treatment Acceptability/Adherence Scale (TAAS); Credibility/Expectancy Questionnaire (CEQ); System Usability Scale (SUS); Feasibility (proportion of subjects who agree to participate in the offered treatment, complete assigned exercises, and complete the entir | Trail Making Test Part B; Montgomery-Asberg Depression Scale (MADRS); World Health Organization Disability Assessment Schedule (WHODAS); Everyday Cognition (ECog); Verbal Fluency; Stroop Color and Word Test; Fatigue Assessment Scale (FAS); California Verbal Le |
| NCT06511050 | Investigating the Effects of Lumbrokinase in Adults With Long Covid, Post-treatment Lyme Disease Syndrome, and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome | RECRUITING | PHASE1; PHASE2 | Icahn School of Medicine at Mount Sinai | EuroQol Visual Analogue Scale Score (EQ-VAS) | The EuroQol Five-Dimensional Health Questionnaire (EQ-5D-5L); 10-Meter Walk Test; Root mean square of successive differences between normal heartbeats (RMSSD); BrainCheck Cognitive Assessment Battery; General Symptom Questionnaire (GSQ-30); Medical Research Co |
| NCT05219929 | T4 - Tetracycline Treatment Tolerability Trial A Pilot Study Examining the Feasibility and Tolerability of Tetracycline Therapy in Post-Treatment Lyme Disease (PTLD) | ENROLLING_BY_INVITATION | PHASE2 | Johns Hopkins University | Participant Retention; Tolerability as assessed by number of side effects; Tolerability as assessed by severity of side effects | Fatigue as assessed by the Fatigue Severity Scale |
| NCT05813873 | The Use of Incentive Spirometry (Triflow) in Patients With Long Covid | ACTIVE_NOT_RECRUITING | nan | European University Cyprus | Barthel Index; Barthel Index; Dyspnoea (Medical Research Council Dyspnoea Scale); Dyspnoea (Medical Research Council Dyspnoea Scale); Peak Flow Meter; Peak Flow Meter | Number of hospitalisation days; Muscle strength (Hand Grip); Muscle strength (Hand Grip); Muscle strength and endurance (30 seconds Sit to stand); Muscle strength and endurance (30 seconds Sit to stand); Balance (Berg Balance); Balance (Berg Balance); Cardiore |
| NCT05019963 | Enhancing COVID Rehabilitation With Technology (ECORT): An Open-label, Single Site Randomized Controlled Trial Evaluating the Effectiveness of Electronic Case Management for Indivi | ACTIVE_NOT_RECRUITING | nan | University of Ottawa | Change in WHODAS 2.0 score | WHO Post-COVID CRF; PHQ-9; GAD-7; PSQI; PCL-5; EQ-5D-5L; Fatigue Severity Scale; Fatigue Numeric Rating Scale; Pain Numeric Rating Scale; MRC Dyspnoea Scale; WEMWBS; Oral Trail Making Test A and B; Hopkins Verbal Learning Test-Revised (HVLT-R); Digit Span subs |
| NCT07627815 | Phase II, Proof of Concept, Open-Label, Randomized-Controlled Trial Evaluating the Efficacy and Safety of PARAGON Novel Metabolic Regulator Formula (PNMR) in the Management of Long | RECRUITING | PHASE2 | ParagonClinicals Inc. | Change in distance walked on the 6-minute walk test (6MWT) after 6 weeks of treatment. | Change in distance walked on the 6MWT after 3 weeks of treatment.; Proportion of patients achieving an improvement of 30 meters or more on the 6MWT by 3 and 6 weeks on treatment.; Time to achieving an improvement of 30 m or more on the 6MWT by 6 weeks on treat |
| NCT05731570 | Cognitive Impairment in Long Covid: PhEnotyping and RehabilitatiOn (CICERO) | ACTIVE_NOT_RECRUITING | nan | University College, London | Change in Goal-attainment | Change in cognitive function; Change in quality of life (EQ-5D-5L); Change in Life Space Questionnaire; Social Functioning (SF-DEM); Change in Instrumental Activities of Daily Living (IADL) Scale; Generalised Anxiety Disorder Assessment (GAD-7); Change in Pati |
| NCT06739720 | A Randomized, Waitlist-controlled Clinical Study on the Efficacy and Safety of Lingzhi-containing Dietary Supplement CP003 on Chronic Fatigue and Post-COVID Fatigue | NOT_YET_RECRUITING | PHASE2; PHASE3 | The University of Hong Kong | Mean difference in Chalder Fatigue Score | Mean difference in Chalder Fatigue Score; Mean difference in 36-Item Short-Form Health Survey; Mean difference in Fatigue Severity Score; mean difference in (PROMIS) Short Form Fatigue 7A survey; Mean difference in hospital anxiety and depression scale; Mean d |
| NCT06511063 | Investigating the Feasibility of Repurposing HIV Antivirals in Adults With Long Covid | RECRUITING | PHASE2 | Icahn School of Medicine at Mount Sinai | EuroQol 5-Dimension 5-Level (EQ-5D-5L) Visual Analogue Scale | The EuroQol Five-Dimensional Health Questionnaire (EQ-5D-5L); Patient-Reported Outcomes Measurement Information System 29 (PROMIS-29); General Symptom Questionnaire (GSQ-30); Patient Health Questionnaire (PHQ-9); Generalized Anxiety Disorder (GAD-7); Neuro-QoL |
| NCT06952413 | An Exploratory, Placebo-controlled, Double-blind, Phase II Study of the Efficacy and Safety for Rituximab (Genetical Recombination) in Myalgia Encephalomyelitis/Chronic Fatigue Syn | RECRUITING | PHASE2 | National Center of Neurology and Psychiatry, Japan | Improvement rate | Percentage of patients whose MHLW-PS-based ME/CFS severity score improved by 1 or more at each evaluation point (improvement rate) compared to that before the start of treatment with the investigational drug (week 0).; The amount of change in the severity scor |
| NCT06204458 | Evaluation of the Efficacy of Mild Water-filtered Infrared-A Whole-body Hyperthermia to Improve Symptoms and Quality of Life in Patients With Post-COVID Syndrome (HyPoCo) | ACTIVE_NOT_RECRUITING | nan | Universität Duisburg-Essen | Multidimensionl Fatigue Inventory (MFI-20); Multidimensionl Fatigue Inventory (MFI-20) | Multidimensionl Fatigue Inventory (MFI-20); Brief Pain Inventory (BPI) - Intensity of pain (Numeric Rating Scale, NRS); Brief Pain Inventory (BPI) - Intensity of pain (Numeric Rating Scale, NRS); Brief Pain Inventory (BPI) - Intensity of pain (Numeric Rating S |
| NCT06042751 | Randomized Comparison of a Telemedicine-supported Psychosomatic Intervention, a Physical Activity Intervention and the Combination of Both in Patients With Post-covid19 Syndrom. | ACTIVE_NOT_RECRUITING | nan | Hannover Medical School | Fatigue | Health-related quality of life; Depression and Anxiety; Physical and psychological fatigue severity; Post-exertional malaise; Multidimensional Fatigue Inventory; Disability; Work ability; Illness Perception |
| NCT ID | Title | Status | Phase | Sponsor | Primary endpoint | Secondary endpoint |
|---|---|---|---|---|---|---|
| NCT05104749 | Homeopathic Treatment of Post-acute COVID-19 Syndrome- A Pilot Randomized Controlled Trial | COMPLETED | PHASE3 | Southwest College of Naturopathic Medicine | Fatigue Assessment Scale (FAS); SF-36 Physical Composite Score (PCS); SF-36 Mental Composite Score (MCS) | Patient Health Questionnaire-9 (PHQ-9); Measure Yourself Medical Outcomes Profile Symptom #1; Measure Yourself Medical Outcomes Profile Symptom #2; Patient Doctor Depth of Relationship (PDDR) |
| NCT05999435 | A DOUBLE-BLIND, RANDOMIZED, PLACEBO-CONTROLLED, ADAPTIVE PHASE 2/3 STUDY OF THE EFFICACY OF LAU-7b IN THE TREATMENT OF ADULTS WITH LONG COVID AND MODERATE TO SEVERE SYMPTOMS | COMPLETED | PHASE2; PHASE3 | Laurent Pharmaceuticals Inc. | Change From Baseline in Physical Component Summary (PCS) of the Medical Outcomes Study Short-Form-36 (SF-36) at Week 12 | Safety of LAU-7b, Overview; Patient Global Impression of Change (PGI-C); Proportion of Participants With Marked Improvement in PGI-C; Change From Baseline in the Functional Assessment of Chronic Illness Therapy Fatigue (FACIT-F) Scale; Change From Baseline in |
| NCT05970861 | Effect of Natural Food on Gut Microbiome and Phospholipid Spectrum of Immune Cells in COVID-19 Patients | COMPLETED | nan | Asfendiyarov Kazakh National Medical University | Gut Microbiome; Antiphospholipid Antibodies; Biochemical Blood Analysis (Uric Acid); Quality of Life Changes | Biochemical Blood Analysis (ALT); Biochemical Blood Analysis (AST); Biochemical Blood Analysis (Glucose); Biochemical Blood Analysis (Triacylglycerides); Biochemical Blood Analysis (Alkaline Phosphatase) |
| NCT06208696 | Pilot Study to Evaluate the Role of an Evidenced-based Chronic-disease Self-management Program to Support Challenges Experiencing Patients Living With Long-COVID and Chronic Diseas | COMPLETED | nan | University of Puerto Rico | Assessment of the Impact of Health-related Quality of Life; Assessment of the Fatigue in the Impact of the Health-related Quality of Life; Assessment of the Anxiety in the Impact of Health-related Quality of Life | Chronic Diseases Self-management; Auto-efficacy for Disease Management |
| NCT05946551 | Feasibility Assessment of a Decentralized Platform Adaptive Double-Blind, Randomized Controlled Trial Investigating Repurposed Drugs in the Treatment of Post-Acute Sequelae of Coro | TERMINATED | PHASE3 | Emory University | Number of Participants That Had Any Confusion Over How to Take the Study Drug, Including Which Pill to Take, When to Take it, or How Many to Take; Number of Participants That Had Trouble Adhering to the Study Drug Schedule; Number of Participants That Had Any | Proportion of Survey Completion; Proportion of Study Drug Adherence; Proportion of Lost to Follow Up (LFUP); Proportion of Voluntary Termination; Adverse Events (AEs) Incidence; Serious, Unexpected Suspected Adverse Reactions (SUSAR) Incidence; Study-wide Seri |
| NCT05513560 | REcovering From COVID-19 Lingering Symptoms Adaptive Integrative Medicine (RECLAIM) | COMPLETED | PHASE2; PHASE3 | University Health Network, Toronto | SF-36 physical component score (PCS) | Symptoms scale; Symptom Checklist; Six Minute Walking Test (6MWT) with oximetry; TestMyBrain cognitive testing; Post COVID19 functional status scale; Reintegration to Normal Living Index (RNLI); Fatigue Scale; Brief Fatigue inventory; Post-Exertional Malaise; |
| NCT04591210 | Evaluation of the Potential Benefit of Renin-angiotensin System Inhibitors (RASi, ACEi/ARB) in High-risk Patients With COVID-19. The COVID-RASi Trial | COMPLETED | PHASE3 | Ottawa Heart Institute Research Corporation | Death; Mechanical ventilation; ICU admission; Major Adverse Cardiac Events (MACE); Hospitalizations; Quality of life of study participants; Quality of life of study participants | Days alive and out of hospital; Days alive and out of hospital; Cardiovascular mortality; All cause hospitalization; Percent of patients require intensive care; Percent of patients requiring ventilation; Percent of patients requiring dialysis |
| NCT04705831 | A Randomized, Double Blind, Placebo Controlled, Cross-Over, Proof-of-Concept Study to Evaluate the Benefit of RUCONEST (C1 Esterase Inhibitor [Recombinant]) in Improving Neurologic | COMPLETED | PHASE2 | IMMUNOe Research Centers | Neuropsychological Measures (BRIEF-A); Neuropsychological Measures (BRIEF-A); Neuropsychological Measures (BRIEF-A); Neuropsychological Measures (RBANS); Neuropsychological Measures (RBANS); Neuropsychological Measures (RBANS); Neuropsychological Measures (BDI | nan |
| NCT05823896 | An Interventional, Double-Blinded, 2-Arm Study to Investigate the Efficacy of Orally Administered Nirmatrelvir/Ritonavir Compared with Placebo/Ritonavir in Non-hospitalized Adult P | COMPLETED | PHASE2 | Karolinska Institutet | Change from baseline in quality of life over time | Change from baseline in quality of life over time; Change from baseline in hemodynamic response over time; Change from baseline in dysautonomia over time; Change from baseline in fever in patients with POTS over time; Change from baseline in endothelial functi |
| NCT05760092 | The Use of Photobiomodulation in the Treatment of Oral Complaints of Long COVID-19. A Randomized Controlled Trial. | COMPLETED | PHASE2 | University of Nove de Julho | Brazilian version of the SF 36 Quality of Life Scale; Nutritional assessment; Salivary ph, Stimulated salivary flow and unstimulated salivary flow; Oral Health Impact Profile (OHIP-14); Xerostomia Inventory XI; Functional Independence Measure (FIM); Post-Covid | nan |
| NCT05703074 | The Efficacy and Safety of a Mental Intervention Program vs. Usual Care and Nicotinamide Riboside (NR) vs. Placebo for Improving Health-related Quality of Life in Long Covid: A 2 x | ACTIVE_NOT_RECRUITING | PHASE2 | University Hospital, Akershus | Health-related quality of life | Inflammation; Executive functioning; Fatigue; Dyspnoea; Global impression of change; Cost-effectiveness |
| NCT05855369 | A Randomized Controlled Trial of Smell Training and Trigeminal Nerve Stimulation in the Treatment of COVID-related Persistent Smell Loss | RECRUITING | PHASE2; PHASE3 | Medical University of South Carolina | Change in Psychophysical Olfactory Function from Baseline to 4 and 12 Weeks; Change in Perceived Intensity of Odorants from Baseline to 4 and 12 Weeks; Change in Perceived Hedonics of Odorants from Baseline to 4 and 12 Weeks; Change in Olfactory-related Qualit | Change in Long COVID Symptoms from Baseline to 4 and 12 Weeks; Change in Sustained Attention from Baseline to 4 and 12 Weeks; Change in Cognitive Function from Baseline to 4 and 12 Weeks; Change in Mood State from Baseline to 4 and 12 Weeks; Change in Sleep Qu |
| NCT06004310 | Effect of Pulmonary Rehabilitation Among Post-COVID-19 Patients in a Tertiary Care Hospital in Bangladesh: A Quasi-Experimental Study | COMPLETED | nan | Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh | Distance: Six-minute walking test (6MWT); Respiratory outcomes: FVC, FEV1, FEV1/FVC ratio, DLCO; Quality of life: Short Form 36 Health Survey Questionnaire (SF-36); Laboratory investigations: CRP and D-dimer | nan |
| NCT06137716 | Development and Clinical Trials of a Rehabilitation Platform to Accelerate the Recovery of Patients With COVID Neuromotor Sequelae | COMPLETED | nan | University of Valladolid | Barthel Index (BI); Functional Independence Measure (MIF); SF-36 Health Questionnaire; Range of motion | Semi-structured interview |
| NCT07280572 | RECLAIM: an Adaptive Platform Trial for the Evaluation of Treatments for Post-Acute Sequelae of SARS-CoV-2 Infection (PASC) | ENROLLING_BY_INVITATION | PHASE3 | Janneke van de Wijgert | Physical health-related quality of life (HRQoL) | Mental HRQoL; Other aspects of HRQoL; Fatigue; Post Exertional Malaise (PEM); Cognitive functioning; Post Orthostatic Tachycardia Syndrome (POTS); Safety of IPs; Tolerability of IPs; Durability of IP treatment responses |
| NCT06726772 | Post-COVID-19 Symptom Burden: Effects of an Outpatient Group Psychotherapy in Long COVID Patients | COMPLETED | nan | Cantonal Hospital of St. Gallen | Change of Fatigue Score measured with the Questionnaire "FSS" (Fatigue Severity Scale) from baseline to 8 weeks; Change of Insomnia Score measured with the Questionnaire "ISI" (Insomnia Severity Index) from baseline to 8 weeks; Change of Qu | nan |
| NCT07301580 | Physical Prehabilitation of Breast Cancer-Related Lymphedema | COMPLETED | nan | University of Health Sciences Balikesir Hospital Eduation and Research | Incidence of Lymphedema Development; Pain Intensity; Quality of Life Impairment | Upper Extremity Function; Exercise Adherence |
| NCT05697640 | A Parallel-group Treatment, Phase 2a, Double-blind, Placebo-controlled 2-arm Study to Show Improvement of Physical Function in SF-36 (SF-36-PF) in Participants Treated With Vericig | ACTIVE_NOT_RECRUITING | PHASE2 | Charite University, Berlin, Germany | Improvement in Physical Function (PF) as measured by the Short Form 36 Health Survey Questionnaire (SF-36) | Difference in responder rate in Physical Function (PF) as measured by the Short Form 36 Health Survey Questionnaire (SF-36) comparing Vericiguat with placebo; Improvement in other sub-domains of the Short Form 36 Health Survey Questionnaire (SF-36) comparing V |
| NCT07553897 | Effectiveness of a Tele-Exercise Training Program on Long COVID Symptoms and Quality of Life in Patients With Long COVID | COMPLETED | nan | Tri-Service General Hospital | Long COVID Symptoms; Cardiorespiratory Fitness - Peak Oxygen Uptake (VO₂peak); Cardiorespiratory Fitness - Peak Workload; Cardiorespiratory Fitness - Anaerobic Threshold; Health-Related Quality of Life | Safety and adverse events |
| NCT05435456 | Effect of Strengthening and Relaxation Exercises on Musculoskeletal Pain, Anxiety, and Sleep Quality on Post-covid Symptoms | COMPLETED | nan | Halic University | McGill Pain Scale short form (SFMPQ); Short-Form 36 (SF-36); Pittsburg Sleep Quality Index; Beck Anxiety Scale | nan |
| NCT05531019 | COVID-19 Sequelae: Treatment and Monitoring of Persistent Symptoms, a Decentralized Approach Focus on the Patient. Use of Dietary Supplement Based on Sea Urchin Eggs With Echinochr | COMPLETED | nan | Fernando Saldarini | Change of symptoms over time-points (baseline, 4 weeks, 8 weeks, 12 weeks) during rutine medical checkup.; Change of lung capacity over four times (baseline, 4 weeks, 8 weeks, 12 weeks) assessed during spirometry.; Change of walking distance during a six minut | Change of Von Willebrand Factor over time-points (baseline, 4 weeks, 12 weeks, 12 weeks) via blood sample.; Change of D Dimer over time-points (baseline, 4 weeks, 12 weeks, 12 weeks) via blood sample.; Change of HS-CRP over time-points (baseline, 4 weeks, 8 we |
| NCT06568393 | The Effect of Calisthenic Exercises on Quality of Life in Post-Covid Syndrome: A Randomized Controlled Trial | COMPLETED | nan | Bahçeşehir University | EQ-5D-3L (European Quality of Life 5 Dimensions 3 Level Version) | nan |
| NCT05532904 | Evaluation and Comparison of Multidisciplinary Day-hospital Versus Waiting List Management of Persistent Symptoms After an Acute Episode of COVID-19 | COMPLETED | nan | Assistance Publique - Hôpitaux de Paris | Quality of life | Quality of life; Fatigue; Dyspnea; Cognitive complaint; Pain; Patient's satisfaction; Physical fitness; Post-effort heart rate; Weight loss; BMI; Blood albumin; Nutritional risk; Health beliefs associated with persistent symptoms |
| NCT05793736 | A Feasibility Study of an HVR Protocol Biofeedback Training to Manage Long Covid Syndrome Symptoms | COMPLETED | nan | University of Cagliari | Change from Baseline to 5 weeks and to 9 weeks in Patient Health Questionnaire-9 (PHQ-9) score; Change from Baseline to 5 weeks and to 9 weeks in Brief Fatigue Inventory (BFI) score; Change from Baseline to 5 weeks and to 9 weeks in Short Form Health Survey (S | nan |
| NCT06960928 | Low Dose Sirolimus in People With Post-Acute Sequelae of COVID-19 (PASC) Long COVID-19 | RECRUITING | PHASE3 | Icahn School of Medicine at Mount Sinai | European Quality of Life-Visual Analogue Scale (EQ-VAS) | The EuroQol Five-Dimensional Health Questionnaire (EQ-5D-5L); Patient-Reported Outcomes Measurement Information System 29 (PROMIS-29); General Symptom Questionnaire (GSQ-30); Patient Health Questionnaire (PHQ-9); Generalized Anxiety Disorder (GAD-7); Neuro-QoL |
| NCT05631171 | COVIDAI: Feasibility Study of Adhera® Fatigue Digital Program for Patients With Long COVID-related Fatigue | COMPLETED | nan | Adhera Health, Inc. | Health-related quality of life; Health-related quality of life; Health-related quality of life; Fatigue; Fatigue; Fatigue; Emotional wellness; Emotional wellness; Emotional wellness | Behavioral outcome: Usability; Behavioral outcome: Usability; Fatigue-related symptomatology; Fatigue-related symptomatology; Mood; Mood; Mood; Social, psychological and emotional wellness; Social, psychological and emotional wellness; Social, psychological an |
| NCT06251011 | Effects of Physiotherapy Via Telerehabilitation on Cardiopulmonary, Physical, and Psychological Functions in Patients With COVID-19: A Randomized Controlled Trial | COMPLETED | nan | Chulabhorn Hospital | Cardiopulmonary function; Patient's quality of life; Functional capacity; Anxiety and depression; Insomnia; Cognitive function; Muscle strength | nan |
| NCT04158427 | Intestinal Microbiota and Chronic Fatigue Syndrome. Effect of Fecal Transplant on Health Related Quality of Life of the Patients With Chronic Fatigue Syndrome | COMPLETED | nan | Tampere University Hospital | Health related quality of life assessed by EQ-5D-5L questionnaire; Health related quality of life assessed by 15D questionnaire; Health related quality of life assessed by Modified Fatigue Impact Scale; Ability to work or study; Visual Analog Fatigue Scale | Health related quality of life assessed by EQ-5D-5L questionnaire; Health related quality of life assessed by 15D questionnaire; Health related quality of life assessed by Modified Fatigue Impact Scale; Ability to work or study; Visual Analog Fatigue Scale |
| NCT05566379 | Effects of a Mindfulness Intervention on Physical and Psychological Well-Being and Quality of Life in Patients With Post Acute Sequelae of SARS-CoV-2 Infection (PASC) Dysautonomia | COMPLETED | nan | University of California, Los Angeles | Change from baseline in the composite autonomic symptom score COMPASS-31 for autonomic symptoms; Change from baseline in Active Stand Test of hemodynamic symptom parameters, exercise tolerance.; Change from baseline of Six Minute Walk in hemodynamic parameters | Change from baseline in mean scores of PSS- Perceived Stress Scale.; Change from baseline in mean scores of GAD7- Generalized Anxiety Disorder; Change from baseline in mean scores of PHQ-8 - Depressive Symptoms; Change from baseline in mean scores of IES-R - e |
| NCT07057999 | Effects of the MIND Diet on Fatigue, Quality of Life, and Brain Fog in Patients With Multiple Sclerosis: A Randomized Controlled Trial | COMPLETED | nan | Betul Uner | The Effect of the MIND Diet on Quality of Life; Effect of the MIND diet on fatigue in MS patients; The effect of the MIND diet on brain fog in MS patients | The effect of the MIND diet on blood parameters; Effect of the applied MIND diet on body composition |
| NCT05507190 | Self-management of Post COVID-19 Syndrome Using Wearable Biometric Technology | COMPLETED | nan | University of Manitoba | Change in lung capacity; Change in dyspnea; Change in fatigue; Chronic fatigue syndrome; Health-related quality of life; Postural orthostatic hypotension; Exercise capacity | Symptoms change; Patient satisfaction with the study |
| NCT05597774 | Effects of Respiratory Muscle Training Combined With an Exercise Training Program in Individuals With Long-term Post-COVID-19 Symptoms | COMPLETED | nan | Universidad Complutense de Madrid | Change in quality of life; Change in exercise tolerance | Change in respiratory muscle function; Change in physical function; Change in pulmonary function; Change in psychological status |
| NCT05172206 | Symptom-based Rehabilitation Compared to Usual Care in Post-COVID - a Randomized Controlled Trial | COMPLETED | nan | Schön Klinik Berchtesgadener Land | Change from baseline Quality of life assessed by Short Form - 12 Questionnaire at week 4 and week 12 | Change from baseline COVID-related symptoms at week 4 and week 12; Change from baseline lung function at week 4 and week 12; Change from baseline blood gas analysis at week 4 and week 12; Change from baseline Cardiac Doppler echocardiography at week 4 and week |
| NCT07182578 | Programming Aquatic Therapy for POTS | COMPLETED | nan | California State University, Dominguez Hills | World Health Organization Quality of Life - Brief (WHOQOL-BREF); The DePaul Symptom Questionnaire (Short Form) (DSQ-SF); Composite Autonomic Symptom Score-31; Malmo POTS Scale (MAPS); ADLS, IADLS, and Vestibular Questionnaire; Active Stand Test; Single leg sta | The Stroop Test; Trail Making Test Parts A & B; Enrollment; Attrition Rate; Session attendance rate; Cost analysis; Health utilization changes; Satisfaction Analysis; Exercise self-efficacy; Goal Attainment Scaling; Beighton Score |
| NCT07279272 | The Effect of the Human Regenerator Jet Device on the Quality of Life of Adult Individuals [HR-QoL] | COMPLETED | nan | University of Athens | EURO-QOL Quality of Life Health Assessment (License no. 62101) | nan |
| NCT07363655 | Effects of a Rehabilitation Programme Focused on Energy Management in People With Myalgic Encephalomyelitis / Chronic Fatigue Syndrome | COMPLETED | nan | Escola Superior de Saúde Norte da Cruz Vermelha Portuguesa | Functional Assessment; Quality of Life Measure; Fatigue Assessment | nan |
| NCT07380152 | Corticosteroid Treatment for Post-COVID-19 Persistent Interstitial Lung Disease | COMPLETED | PHASE1 | University of Sao Paulo | The rate of radiological, functional and quality of life improvement in prednisolone treatment for persistent interstitial lung disease following SARS-CoV-2. | The incidence of risk factors that may influence the severe outcome of COVID-19 lung disease.; Monitoring of post-COVID lung disease. |
| NCT05305105 | Effects of Psilocybin in Post-Treatment Lyme Disease | COMPLETED | PHASE1 | Johns Hopkins University | Change in multi-system symptom burden as assessed by the General Symptom Questionnaire (GSQ-30) score; Change in functional health and well-being as assessed by the Short Health Form (SF-36) score | Change in fatigue as assessed by the Fatigue Severity Scale (FSS) score; Change in pain as assessed by the Short-Form McGill Pain Questionnaire (SF-MPQ) |
| NCT05894629 | Effects of an Active Coping Program in Patients With Persistent Post-Covid Pain. | COMPLETED | nan | University of Valladolid | Quality of life (QoL) | Pain Intensity; Body Chart; Quantitative sensory tests; Handgrip Strength assessment; 30 sit to stand test; 6 Minute Walking Test (6MWT); Maximal Inspiratory and Expiration Pressure (MIP/MEP); Catastrophism; Anxiety; Depression; Drug consumption.; Fatigue |
| NCT04943276 | A Novel Noninvasive Thermoregulatory Device for Postural Tachycardia | COMPLETED | nan | Stanford University | Change from baseline in Compass-31 survey at study endpoint; Change from baseline in Pittsburg Sleep Quality Index (PSQI) at study endpoint; Change from baseline in Insomnia Severity Scale Index (ISI) at study endpoint; Temperature Quality of life Questionnair | nan |
| NCT06601920 | A Study of Activity Leader to Forest Therapy Campaign in Different Environments Targets on the Participants Which Had Been Infected by SARS-COV-2 | COMPLETED | nan | Taipei City Hospital | Profile of Mood States 2nd Edition-Adult Short, POMS; The Beck Anxiety Inventory, BAI; The Beck Depression In- ventory-Second edition, BDI-II; The brief World Health Organization Quality of Life, WHOQOL-BREF; Fear of COVID-19 Scale, FCV-19S; Salivary Amylase E | Post-COVID Functional Status, PCFS; Blood pressure, Heart rate, and Heart rate variability |
| NCT06492590 | Assessing a Multicomponent Intervention to Improve Quality of Life in Individuals With Long COVID-19 (COVIDL/MIQoL): A Randomized Controlled Trial | COMPLETED | nan | Consorci Sanitari de Terrassa | Improved quality of life | Improve well-being; Decreased anxiety and depression; Increased resilience; Improve physical activity; Decreased fatigue |
| NCT06379737 | Valutazione Degli Esiti a Medio-lungo Termine Della Sindrome Long Covid in Pazienti Trattati Con un Protocollo di Riabilitazione in Ambiente Termale o in Teleriabilitazione | COMPLETED | nan | Padua University General Hospital | Numerical Rating Scale (NRS); Hand grip strength; Barthel Dyspnea Scale; Fatigue Assessment Scale; Beck's Depression Inventory (BDI; Beck Anxiety Inventory (BAI); 12-Item Short Form Health Survey (SF-12) | Patients satisfaction |
| NCT05956405 | Retraining of the Amygdala and Insula for the Treatment of Persistent Covid | COMPLETED | nan | Hospital Miguel Servet | Short Form de 36 items (SF-36); Short Form de 36 items (SF-36); Short Form de 36 items (SF-36); Short Form de 36 items (SF-36); Short Form de 36 items (SF-36); Short Form de 36 items (SF-36) | Sociodemographic data Gender, age, marital status, education, occupation, economical level; Sociodemographic data Gender, age, marital status, education, occupation, economical level; Spanish Chronic Pain Grading Scale; Spanish Chronic Pain Grading Scale; Span |
| NCT04996212 | Study of the Effectiveness of a Cardiorespiratory Telerehabilitation Program in Persistent COVID-19 Patients. Randomized Clinical Trial. | COMPLETED | nan | University of Valencia | Quality of life (EQ-5D-5L) | Quality of life (EQ-5D-5L) Change from Baseline PostCovid-19 Functional Satatus Scale at five months (PCFSS); Fatigue Assessment Scale (FAS); London Chest Activity of Daily Living Scale (LCADL); Hospital Anxiety and Depression Scale (HADS); Perceived Stress Sc |
| NCT06391489 | Piloting A Telehealth Deliverable Self-Management and Cognitive Training Program (HOBSCOTCH, HOme Based Self-Management and COgnitive Training CHanges Lives) for People With Post A | ACTIVE_NOT_RECRUITING | nan | Dartmouth-Hitchcock Medical Center | Change in overall quality of life as measured by comparing PROMIS-10 Global Health scores pre- and post-HOBSCOTCH-PACS intervention.; Change in subjective cognition as measured by comparing Neuro-QOL Item Bank v2.0 Cognitive Function scores pre- and post-HOBSC | Change in objective cognition as measured by comparing Symbol-Digit Modalities Test scores pre- and post-HOBSCOTCH-PACS intervention.; Change in objective cognition as measured by comparing California Verbal Learning Test-III scores pre- and post-HOBSCOTCH-PAC |
| NCT05409651 | Phenotyping Mitochondrial and Immune Dysfunction in POTS With Targeted Clinical Intervention. | ACTIVE_NOT_RECRUITING | nan | University of California, San Diego | Conduct a pilot clinical trial with POTS patients to assess if TRE can improve Quality of Life. | nan |
| NCT07240649 | Emerging Indications for Hyperbaric Oxygen Treatment | NOT_YET_RECRUITING | PHASE4 | Jay C. Buckey Jr. | Quality of Life EuroQOL EQ-5D-5L Questionnaire | Urogenital Distress Inventory; Bowel symptoms questionnaire; Head and Neck Questionnaire; Perianal Crohn's Symptom Index Questionnaire; Hip dysfunction and Osteoarthritis Outcome Score (HOOS) Questionnaire; Wound Score (Strauss Score); Subjective Assessme |
| NCT07559994 | Diagnostic and Clinical Management of Non-Obstructive Myocardial Ischemia in Patients With Long Covid-19 Syndrome and New Onset Chest Pain: the Long Covid-19 INOCA Trial | ACTIVE_NOT_RECRUITING | nan | Fundacion Investigacion Interhospitalaria Cardiovascular | The changes in angina symptom and quality of life assessed by Seattle Questionnaire of Angina score in the treatment guided group comparing to the standard of care group | The prevalence and type of INOCA in LCS patients with chest pain |
| NCT06511063 | Investigating the Feasibility of Repurposing HIV Antivirals in Adults With Long Covid | RECRUITING | PHASE2 | Icahn School of Medicine at Mount Sinai | EuroQol 5-Dimension 5-Level (EQ-5D-5L) Visual Analogue Scale | The EuroQol Five-Dimensional Health Questionnaire (EQ-5D-5L); Patient-Reported Outcomes Measurement Information System 29 (PROMIS-29); General Symptom Questionnaire (GSQ-30); Patient Health Questionnaire (PHQ-9); Generalized Anxiety Disorder (GAD-7); Neuro-QoL |
| NCT06907251 | Dapagliflozin for Long COVID Syndrome | NOT_YET_RECRUITING | PHASE3 | Ottawa Heart Institute Research Corporation | 6 month change in EQ-5D derived utility score. | Incident diabetes; Cardiovascular Event |
| NCT05094622 | Physical Exercise in Patients With Postural Orthostatic Tachycardia Syndrome (POTS) After Covid-19. | ACTIVE_NOT_RECRUITING | nan | Karolinska Institutet | Change in Health-Related Quality of Life (HRQoL); Change in time in upright position and steps per day | Change in walking distance during 6 minute walk test; Change in oxygen saturation during 6 minute walk test; Change in oxygen desaturation during 6 minute walk test; Change in dyspnea during 6 minute walk test; Change in leg fatigue during 6 minute walk test; |
| NCT06231238 | A Randomised Controlled Trial Assessing the Efficacy of Balance Acceptance and Commitment Therapy (ACT) for Long COVID. | ACTIVE_NOT_RECRUITING | nan | King's College London | Physical Component Summary (PCS) of the 36-item Short Form Health Survey (SF-36) at Week 14 | EuroQol 5 Dimension - 5 Levels (EQ-5D-5L); Adult Service Use Schedule; Functional Assessment of Chronic Illness Therapy - Fatigue (FACIT-F); Modified Clinical Global Impressions Scale- Improvement (CGI-I); Pittsburgh Sleep Quality Index (PSQI); Modified Patien |
| NCT06124625 | Effects of Rehabilitation Combined With a 12-week Maintenance Program Compared to Rehabilitation Alone in Post-COVID-19 - a Randomized, Controlled Trial. | ACTIVE_NOT_RECRUITING | nan | Schön Klinik Berchtesgadener Land | Change from baseline quality of life assessed by Short-Form 12 questionnaire at week 4 and week 19 | Change from baseline post-COVID-related symptoms at week 4 and week 19; Change from baseline lung function at week 4 and week 19; Change from baseline fatigue symptoms at week 4 and week 19; Change from baseline exercise capacity at week 4 and week 19; Change |
| NCT05719493 | Effectiveness and Health Benefits of a Nutritional, Chronobiological and Physical Exercise Primary Care Intervention in Fibromyalgia and Chronic Fatigue Syndrome: SYNCHRONIZE + Mix | ACTIVE_NOT_RECRUITING | nan | Fundacio d'Investigacio en Atencio Primaria Jordi Gol i Gurina | change in quality of life | change in fatigue indicator; change in sleep quality and insomnia indicator; change in pain indicator; change in adherence to the Mediterranean diet; change in physical exercise practice and sedentary lifestyle; change in circadian biological rhythm; change in |
| NCT06879925 | The Effects of Qi-gong on Physiology and Quality of Life in Patients with Post-acute Sequelae of Covid-19 | RECRUITING | nan | POCHIWU | Pulmonary Function Test (Forced vital capacity); Pulmonary Function Test (FEV1); Pulmonary Function Test (FVCFEV1); Heart rate variability; Heart rate variability; Heart rate variability; Heart rate variability; Quality of Life(The short version of the World H | nan |
| NCT06267300 | Treatment of Post-COVID-19 With Hyperbaric Oxygen Therapy: a Randomized, Controlled Trial | UNKNOWN | PHASE3 | Erasmus Medical Center | Physical and mental component scores of the 36-item Short Form Survey (SF-36) | Euroqol-5D (EQ-5D); Activity tracking (through wrist band), monitoring heart rate, step count and sleep patterns; Biochemical parameters; Absence from work; Cost-effectiveness |
| NCT06522750 | Pilot Study on the Feasibility of an RCT: Evaluating Periodic Fasting as a Treatment Strategy for Long Covid in Adults | RECRUITING | nan | University of Luxembourg | Nutritional protocol; Fatigue assessment Scale (FAS); Quality of Life (WHOQOL); Functionality (WHODAS 2.0); Anxiety (GAD-7); Depression (PHQ-9); Mood States; Blood preasure | Urine Metabolomics; Gut Microbiome; Stool Metabolomics; Blood cytokines; Blood Mitochondrial dysfunction; Blood Epigenetics; Blood test |
| NCT05220280 | Long-term Follow-up of a Randomized Multicenter Trial on Impact of Imatinib and Infliximab on Long-COVID in Hospitalized COVID-19 Patients | UNKNOWN | PHASE4 | Clinical Urology and Epidemiology Working Group | Long-COVID symptoms; Long-COVID symptoms; Long-COVID symptoms; Health-related quality of life; Health-related quality of life; Health-related quality of life | Mortality; Incidence of comorbidity; Lung function; Lung function; Lung function; Whole-genome sequencing |
| NCT07110714 | Effects of Kneipp Hydrotherapy in Post-COVID-19 Patients: A Randomized Controlled Trial | RECRUITING | nan | Eggensberger OHG | Health-related quality of life by Short Form-12 Health Survey (SF-12) | Fatigue severity by Fatigue Severity Scale; Sleep quality by Pittsburgh Sleep Quality Index; Health status by EuroQol-5 Dimensions-5 Levels; Autonomic function (heart rate variability by photoplethysmography); Resting blood pressure (systolic and diastolic); P |
| NCT05877534 | Effects of Individual Tailored Physical Exercise in Patients With Post COVID-19 Condition, Diagnosed With Postural Orthostatic Tachycardia Syndrome (POTS) - a Randomized Controlled | ENROLLING_BY_INVITATION | nan | Karolinska Institutet | Change in time in upright position and steps per day; Change in Health-Related Quality of Life (HRQoL) | Change in walking distance during 6 minute walk test; Change in oxygen saturation during 6 minute walk test; Change in dyspnea during 6 minute walk test; Change in leg fatigue during 6 minute walk test; Change in exertion during 6 minute walk test; Change in h |
| NCT05525598 | Internet-based Treatment for Patients Suffering From Severe Functional Somatic Disorders: A Randomized Controlled Trial. | RECRUITING | nan | University of Aarhus | Change in SF-36 physical health (SF-36 PPH scales); Clinical Global Improvement Scale (CGI) | The Numeric Rating Scale (NRS); Emotional distress, anxiety, depression subscales of the 92-item Danish version of the Symptom Checklist (SCL-92); The BDS Checklist-25; Whiteley-6 revised; Brief Illness perception questionnaire (b-IPQ); The Behavioural Respons |
| NCT06147050 | Pilot Study of an Adaptive, Double-blind, Randomized, Placebo-controlled Study to Evaluate the Effect of Metformin in Reducing Fatigue in Long COVID Adolescent Patients With Chroni | UNKNOWN | PHASE3 | Purpose Life Sciences | Mean Pediatric Quality of Life Multidimensional Fatigue Scale (PedsQL-MFS) score at 90 days post-randomization | Mean PedsQL-MFS score at 30 days post-randomization; Mean PedsQL-MFS score at 60 days post-randomization; Mean Chalder Fatigue Scale (CFS) score at 30 days post-randomization; Mean CFS score at 60 days post-randomization; Mean CFS score at 90 days post-randomi |
| NCT05268523 | Interventions to Teach Self-management Skills for Persisting Symptoms of COVID-19: Minimizing Impact of Symptoms on Everyday Functioning and on Healthcare Usage/utilization | RECRUITING | nan | Toronto Rehabilitation Institute | Change in Brief-COPE; Change in LOT; Change in Kessler Psychological Distress Scale (K10); Change in SSS-8; Change in Perceived Medical Condition Self-Management Scale; Change in the Depression, Anxiety and Stress Scale; Change in Quality of Life Enjoyment and | Feasibility: session feedback questionnaire; Feasibility: Recruitment rate; Feasibility: Retention rate; Feasibility: Adherence rate; Feasibility: qualitative interview |
| NCT06871293 | Impact of Functional and Cognitive Rehabilitation, in Adults With Chronic Noncommunicable Diseases and Long Covid-19 , on Their Functional and Cognitive Capacity, Quality of Life, | RECRUITING | nan | Fundación Cardioinfantil Instituto de Cardiología | Composite Change in Functional Capacity, Cognitive Function, Health-Related Quality of Life, and Strength | Change in Functional Capacity; Change in Cognitive Function; Change in Health-Related Quality of Life; Change in Health-Related Quality of Life, Visual Analogue Scale; Change in Handgrip Strength, Hydraulic Dynamometer; Incidence of Chronic Disease Decompensat |
| NCT05741112 | The Long COVID-19 Wearable Device Study | RECRUITING | nan | Scripps Translational Science Institute | Primary Objective 1:Assess the effect of study-provided devices and enhanced educational materials to manage Long COVID-19 symptom severity, compared to general educational materials alone using data from participants survey responses.; Primary Objective 2: Co | Secondary Objective: Assess the longitudinal impact of sustained use of the study-provided devices and enhanced educational materials on symptom severity. |
| NCT07013903 | Effects of Kneipp Hydrotherapy During Inpatient Post-Covid-19 Rehabilitation: A Randomized Controlled Trial | RECRUITING | nan | Schön Klinik Berchtesgadener Land | Health-related quality of life by Short Form-12 Health Survey (SF-12) | Fatigue severity by Fatigue Severity Scale; Sleep quality by Pittsburgh Sleep Quality Index; Health status by EuroQol-5 Dimensions-5 Levels; Autonomic function (heart rate variability by photoplethysmography); Resting blood pressure (systolic and diastolic); P |
| NCT06517706 | Brain Research and Integrative Neuroscience Network for COVID-19 (BRAINN) | RECRUITING | nan | University of Cyprus | Categorization Program Test 1; Categorization Program Test 2; Probe Tasks; WHO BREF Quality of Life; Dysexecutive Questionnaire | nan |
| NCT07597902 | SARS-CoV-2 and Herpesvirus Inhibition for Ending Long COVID Dysfunction (SHIELD) | NOT_YET_RECRUITING | PHASE2 | Icahn School of Medicine at Mount Sinai | EQ-5D-5L Visual Analogue Scale (VAS) | The EuroQol Five-Dimensional Health Questionnaire (EQ-5D-5L); Patient-Reported Outcomes Measurement Information System 29 (PROMIS-29); General Symptom Questionnaire (GSQ-30); Patient Health Questionnaire (PHQ-9); Generalized Anxiety Disorder (GAD-7); COLUMBIA- |
| NCT06585254 | Use of Transcutaneous Vagus Nerve Stimulation in Reducing the Symptoms of Long COVID Patients Who Fulfill Diagnostic Criteria for ME/CFS | RECRUITING | nan | Icahn School of Medicine at Mount Sinai | The Chalder Fatigue Questionnaire (CFQ); Change in Short Form Health Survey (SF-36); Visual Analog Scale (VAS) measuring Fatigue; VAS to measure Widespread Pain; VAS measuring Postexertional malaise (PEM); VAS measuring brain fog; Global Clinical Assessment of | Heart Rate Variability (HRV) |
| NCT06082258 | Evaluation of a Training and Support Intervention for General Practitioners Managing Patients With Persistent Symptoms Following a COVID-19 Episode | NOT_YET_RECRUITING | nan | Assistance Publique - Hôpitaux de Paris | Change of physical component summary (PCS) of 12-Item Short-Form Health Survey (SF-12v2) - quality of life scale at 3 months compared to the PCS at the inclusion of the patient | Change of physical component summary (PCS) of 12-Item Short-Form Health Survey (SF-12v2) - quality of life scale at 1 month compared to the PCS at the inclusion of the patient; Change of physical component summary (PCS) of 12-Item Short-Form Health Survey (SF- |
| NCT06795854 | Effect of Aerobic Training Versus Relaxation Techniques on Quality of Life in Patients With Post Covid-19 Irritable Bowel Syndrome | NOT_YET_RECRUITING | nan | Cairo University | IBS Severity Scoring System (IBS-SSS); IBS Quality of Life (IBS-QOL) | The Pittsburgh Sleep Quality Index (PSQI); Perceived Stress Questionnaire (PSQ) |
| NCT06095258 | A Practical Clinical Randomized Controlled Trial of Traditional Chinese Medicine in the Treatment of Long COVID and an Analysis of Syndrome Types and Medication Characteristics of | UNKNOWN | PHASE2 | Chinese University of Hong Kong | 5-level EQ-5D version (EQ-5D-5L); 5-level EQ-5D version (EQ-5D-5L) | Measure Yourself Medical Outcome Profile in Chinese version (CMYMOP2); Measure Yourself Medical Outcome Profile in Chinese version (CMYMOP2); Modified COVID-19 Yorkshire Rehabilitation Scale (C19-YRSm); Modified COVID-19 Yorkshire Rehabilitation Scale (C19-YRS |
| NCT06141317 | Tissue Regeneration and Function Recovery in Patients With Parkinson's Disease Using Allogenic Pluripotent Stem Cells Isolated From Adipose Tissue (PASCs): A Randomized Phase | UNKNOWN | PHASE1; PHASE2 | ClusterXStem-Costa Rica | Change in motor function as assessed by the Unified Parkinson's Disease Rating Scale (MDS-UPDRS) Total Score; Quality of life as assessed by the 39-item Parkinson's disease Questionnaire (PDQ-39); Speech voice sound and duration; Dynamic balance and | Adverse events upon clinical examination; Optimal number of doses of 2.5 x 10^7 PASCs for therapeutic response |
| NCT05823805 | Approaches For ThE pRioritization of Patients in priMAry Care Post-COVID To Reduce Health Inequities (AFTERMATH): Cluster Randomized Controlled Trial | NOT_YET_RECRUITING | nan | Unity Health Toronto | health-related quality of life | Preventive care activities and chronic disease management outcomes |
| NCT06672861 | Development and Validation of the Kansas City Cardiac Dysautonomia Questionnaire (KCDysQ) in Patients With Postural Orthostatic Tachycardia Syndrome, Inappropriate Sinus Tachycardi | NOT_YET_RECRUITING | nan | Kansas City Heart Rhythm Research Foundation | To develop and validate KCDysQ as a quality of life and symptom severity assessment tool | nan |
| NCT06679218 | Improving Health Status in COVID-19 Long-Hauler Through an Activity Coaching Programme: a Randomized Control Trial | NOT_YET_RECRUITING | nan | Universidad de Granada | IPAQ (International Physical Activity Questionnaire); EQ-5D (EuroQol-5 Dimensions); PROMIS (Patient-Reported Outcomes Measurement Information System) | nan |
| NCT07317401 | REenergizeME: Oxygen Therapy (OT) as a Novel Treatment for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) | NOT_YET_RECRUITING | nan | University of Aarhus | Change in SF-36 Vitality Domain score from baseline to post-treatment | Change in health-related quality of life (SF-36 domains); Change in fatigue severity (Fatigue Severity Scale, FSS); Change in functional capacity (FUNCAP-27); Change in autonomic symptoms (COMPASS-31); Objective autonomic, neurophysiological, and functional pe |
| NCT05077241 | Efficacy of Home Inspiratory Muscle Training in Post-covid-19 Patients: a Randomized Clinical Trial | UNKNOWN | nan | Universidade Federal do Rio Grande do Norte | Respiratory muscle strength; Dyspnea - Medical Research Council; Quality of life (SF-36) | Pulmonary function; Exercise tolerance; Functional status; Anxiety and depression; Peripheral muscle strength; Adverse effects and adherence; Physical activity level; Cognition; Perception of effort and fatigue; Functional independence measure |
| NCT06004362 | Complementary and Integrative Medicine as an Online Intervention in Patients With Post-covid Syndrome - a Randomized-controlled Mixed-methods Trial. | UNKNOWN | nan | Charite University, Berlin, Germany | Short Form 36 (SF-36), Physical Functioning Scale | Short Form 36 (SF-36); DePaul Post-Exertional Malaise Questionnaire (DSQ-PEM); Post-COVID-Syndrom (PCS) Score; Chalder Fatigue Scale (CFS); Quality of life (EQ-5D-5L); General Self-Efficacy Scale (GSE, German version: ASKU); Visual analog scale (VAS) physical |
| NCT04532827 | The Effectiveness of Web-based Rehabilitation for Enhancing Workability and Daily Functioning for Persistent Physical Symptoms. | UNKNOWN | nan | Finnish Institute of Occupational Health | The 15D questionnaire (health related quality of life) | Demographic questions: age (years); Demographic questions: gender (male, female, prefer not to say); Demographic questions: marital status (Unmarried, married or cohabiting, divorced or separation, widow); Demographic questions: education (basic, secondary, hi |
| NCT05371288 | The Role of Glutathione Deficiency and MSIDS Variables in Long COVID-19 | WITHDRAWN | EARLY_PHASE1 | University of California, Irvine | Assess Changes in Symptoms of Post-Acute Sequelae of COVID (PASC); Change in Quality of Life Using SF-36 Survey; COVID Severity of Symptoms Questionnaire; Change in Time to Clinical Recovery (TTCR) | nan |
| NCT04742946 | Digital Physiotherapy Practice in Long Covid-19 Patients to Improve Functional Capacity and Quality of Life. | UNKNOWN | nan | Universidad de Granada | Functional Capacity; Functional Capacity; Functional Capacity (SPBB) short performance physical battery test; Functional Capacity (SPBB) short performance physical battery test; The Short Form Health Survey SF-12; The Short Form Health Survey SF-12 Quality of | Telemedicine Satisfaction Questionnaire (TSQ); Cost-effectiveness of the telerehabilitation intervention; Adherence to intervention; Satisfaction and Perception with intervention |
| NCT05669261 | A PILOT STUDY ON RESEARCH TREATMENT OF LONG COVID POST-ACUTE SEQUELAE OF SARS CoV-2 INFECTION ("PASC") USING ATCell™ | UNKNOWN | PHASE1 | American CryoStem Corporation | Assessment of the Incidence of Serious Adverse Events (SAEs); Assessment of change in Health Status using the 36 item Short Form Health Survey (SF-36); Assessment of change in Health Status using the 36 item Short Form Health Survey (SF-36); Assessment of chan | Assessment of Changes in Exosome/Cytokine/Chemokine Testing; Assessment of change in completion time -Six-minute walk test (6MWT); Assessment of Change in Complete blood count with differential (CBC with diff) Laboratory Testing Results; Assessment of Change i |
| NCT04678700 | Implementation of a Respiratory Physiotherapy Program in Post COVID-19 Patients Through Tele-assistance | UNKNOWN | nan | European University of Madrid | Euroqol-5d european quality of life-5 dimensions; Euroqol-5d european quality of life-5 dimensions; Dysnea scale Borg; Dysnea scale Borg; Respiratory rate; Respiratory rate; Effort dysnea Scale; Effort dysnea Scale; Anxiety; Anxiety; Level oxigen %; Level oxig | nan |
| NCT05725538 | Efficacy of Exercise-based mHealth Intervention for Patients With Post-acute COVID-19 Syndrome Based on Fatigue, Fitness, Post-exertional Dyspnea, Pain, Anxiety, Depression, Cognit | UNKNOWN | nan | University of Cadiz | Longitudinal Change from Baseline up to 24 Weeks Follow-up in Fatigue (Fatigue Severity Scale (FSS)); Longitudinal Change from Baseline up to 24 Weeks Follow-up in Post-exertional dyspnoea (Dyspnoea-12); Longitudinal Change from Baseline up to 24 Weeks Follow- | Longitudinal Change from Baseline up to 24 Weeks Follow-up in Pain intensity (Visual Analog Scale (VAS)); Longitudinal Change from Baseline up to 24 Weeks Follow-up in Upper limb strength (Arm curl test); Longitudinal Change from Baseline up to 24 Weeks Follow |
| NCT05951803 | Effectiveness of the Brief Behavioral Intervention for Insomnia in the Teleconsultation Modality (ICBI-TC) on the Symptoms of Anxiety, Depression, Sleep Quality and Quality of Life | UNKNOWN | nan | Hospital General de Mexico | Sleep diary; Patient Health Questionnaire 9 (PHQ-9); Pittsburgh Sleep Quality Index (PSQI); Insomnia Severity Index (ISI); SF-36 Health Survey; Generalized Anxiety Disorder 7 (GAD-7) | Sleep diary; Patient Health Questionnaire 9 (PHQ-9); Pittsburgh Sleep Quality Index (PSQI); Insomnia Severity Index (ISI); SF-36 Health Survey; Generalized Anxiety Disorder 7 (GAD-7); Sleep diary; Patient Health Questionnaire 9 (PHQ-9); Pittsburgh Sleep Qualit |
| NCT05753228 | In Vivo Investigation on Mitochondrial Dysfunction in Post-COVID Fatigue and Cancer Fatigue. | UNKNOWN | nan | National University Hospital, Singapore | MRI, 3D Arterial Spin Labelling (ASL) and 1H magnetic resonance spectroscopy (MRS); Chalder Fatigue Scale; Health Questionnaire (EQ-5D-5L); Hamilton Depression Rating Scale | nan |
| NCT05975034 | Investigation of the Use of a Probiotic Supplement in People With Long COVID | UNKNOWN | nan | Sheffield Hallam University | Fatigue severity scale (FSS); FACIT fatigue scale; EQ-5D-5L; Ability to Participate in Social Roles and Activities - PROMIS Short Form 8a; Ecological Momentary Assessment (EMA) app | IBS-SSS; Gastrointestinal Symptom Rating Scale; MRC Dyspnoea scale; International. Physical Activity Questionnaire (short form); Accelerometery data; Cambridge Neuropsychological Test Automated Battery (CANTAB); 16S rRNA sequencing; Analysis of inflammatory ma |
| NCT05150782 | The Effect of a Mixture of Micellized Curcumin/Boswellia Serrata/Ascorbic Acid on Health-related Quality of Life in Patients With Post-acute COVID-19 Syndrome. | UNKNOWN | nan | PhysioMetrics | Change in health-related quality of life | Change in patient selected functional limitations in daily life, measured with the 'Patient specific functional scale (PSFS).; Change in general health status; Change in general health; Change in Post COVID functional status measured with the 'Post C |
| NCT04961333 | Internet-based Multidisciplinary Rehabilitation for Longterm COVID-19 Syndrome | UNKNOWN | nan | Danderyd Hospital | Change in health-related quality of life measured by Short Form-36; Changes in heart rate variability during physical tests | Overall changed scores in validated questionnaires for fatigue, breathing, pain and sleep disorders; Changed functioning and activity |
| NCT04349605 | Meditation and Yoga for Patients With Persistent Symptoms After Lyme Disease | WITHDRAWN | nan | Research Foundation for Mental Hygiene, Inc. | Fatigue Severity Scale; General Symptom Questionnaire-30; Quality of Life Experience Scale | Pain Visual Analog Scale; Applied Cognition scale; PROMIS-29; SF-12 |
| NCT06063031 | Investigation of a Specialized Nutritional Intervention and Rehabilitation Treatment in Patients With Post-COVID Condition to Improve Their Quality of Life: ARACOV-02 | UNKNOWN | nan | Instituto de Investigación Sanitaria Aragón | Changes in the Quality of life (EQ-5D) | Changes in the Biomarkers; Changes in the Fatigue Severity Scale (FSS); Changes in the Modified Medical Research Council Scale (mMRC); Changes in the Measurements of peak inspiratory pressure and peak expiratory pressure; Changes in the Functional capacity as |
| NCT05289154 | Self- Applied Acupressure and Online Qigong for Patients Suffering From Chronic Fatigue After Corona Virus Infection 19 (COVID-19) - a Randomized Controlled Mixed-methods Study. | UNKNOWN | nan | Charite University, Berlin, Germany | SF-36 Physical Function subscale | EQ5D (EuroQoL 5 domains); SF36 PFS (Short Form 36 physical function subscale); Chalder Fatigue-Scale; VAS physical resilience (visual analogue scale); PHQ9 (Patient Health Questionnaire 9); VAS pain (visual analogue scale); hand grip strength; Spirometry; auto |
| NCT05817032 | Effect of Telerehabilitation Practice in Long COVID-19 Patients: Impact on Stress Oxidative, Inflammation, Functional Capacity and Quality of Life | UNKNOWN | nan | Indonesia University | Change from baseline in quality of life status measured using European Quality of Life 5 Dimension 5 Level (EQ 5D 5L) questionnaire at 12 weeks; Change from baseline the distance from Six Minute Walk Test at 12 weeks; Change from baseline the mean Glutathione | Change from baseline the score from Brief Fatigue Inventory (BFI) questionnaire at 12 weeks; Change from baseline the score from hand grip strength test using handgrip dynamometer at 12 weeks |
| NCT ID | Title | Status | Phase | Sponsor | Primary endpoint | Secondary endpoint |
|---|---|---|---|---|---|---|
| NCT05999435 | A DOUBLE-BLIND, RANDOMIZED, PLACEBO-CONTROLLED, ADAPTIVE PHASE 2/3 STUDY OF THE EFFICACY OF LAU-7b IN THE TREATMENT OF ADULTS WITH LONG COVID AND MODERATE TO SEVERE SYMPTOMS | COMPLETED | PHASE2; PHASE3 | Laurent Pharmaceuticals Inc. | Change From Baseline in Physical Component Summary (PCS) of the Medical Outcomes Study Short-Form-36 (SF-36) at Week 12 | Safety of LAU-7b, Overview; Patient Global Impression of Change (PGI-C); Proportion of Participants With Marked Improvement in PGI-C; Change From Baseline in the Functional Assessment of Chronic Illness Therapy Fatigue (FACIT-F) Scale; Change From Baseline in |
| NCT05970731 | Directed Topical Drug Delivery for Treatment for PASC Hyposmia | COMPLETED | PHASE2 | Duke University | Percentage of Participants Achieving MCID (Minimal Clinically Important Difference) on the Smell Identification Test (SIT) | Change in Olfactory Quality of Life (QOL) Measured by the Questionnaire on Olfactory Disorders (QOD) |
| NCT06133075 | Using Mirabegron to Increase Blood Pressure in Patients With Postural Orthostatic Tachycardia Syndrome | COMPLETED | PHASE2 | Cedars-Sinai Medical Center | Blood Pressure | Syncope; Hypotensive Episode; Duke Activity Status Index Questionnaire; EQ-5D-5L Questionnaire; Seattle Angina Questionnaire (SAQ); Overactive Bladder Symptoms |
| NCT05126563 | A Randomized, Double-blinded, Single-center, Phase 2 Efficacy, and Safety Study of Allogeneic HB-adMSCs for the Treatment of Patients With Chronic Post-COVID-19 Syndrome. | COMPLETED | PHASE2 | Hope Biosciences Research Foundation | Changes From Baseline in Visual Analog Scale of Neurological Symptoms. - Extreme Fatigue (ANCOVA Model); Changes From Baseline in Visual Analog Scale of Neurological Symptoms.. - Brain Fog (ANCOVA Model); Changes From Baseline in Visual Analog Scale of Neurolo | Changes From Baseline in Visual Analog Scale of Non-Neurological Symptoms. - Dyspnea at Rest (ANCOVA Model); Changes From Baseline in Visual Analog Scale of Non-Neurological Symptoms. - Dyspnea During Activity (ANCOVA Model); Changes From Baseline in Visual An |
| NCT06136871 | Cognitive Strategy Training in Post-COVID-19 Syndrome: A Feasibility Trial | COMPLETED | nan | University of Missouri-Columbia | Recruitment Rate; Retention Rate; Telehealth Usability Questionnaire (TUQ); Acceptability of Intervention Measure (AIM); Intervention Appropriateness Measure (IAM); Feasibility of Intervention Measure (FIM); Canadian Occupational Performance Measure (COPM) Per | Delis-Kaplan Executive Function System (DKEFS)- Color-Word Interference, Age-Corrected Time; Delis-Kaplan Executive Function System (DKEFS)- Color-Word Interference, Age-Corrected Errors; Patient-Reported Outcomes Measurement Information System (PROMIS) Cognit |
| NCT05877508 | An Exploratory, Randomized, Double-Blind Placebo-Controlled Study to Assess the Safety of an Anti-SARS-CoV-2 Monoclonal Antibody and Response to Treatment in Individuals With Long | ACTIVE_NOT_RECRUITING | PHASE2 | Michael Peluso, MD | Patient-Reported Outcomes Measurement Information System (PROMIS)-29 Physical Health Summary Score | Patient-Reported Outcomes Measurement Information System (PROMIS)-29 Physical Health Summary Score; Patient-Reported Outcomes Measurement Information System (PROMIS)-29 Mental Health Summary Score; Patient-Reported Outcomes Measurement Information System (PROM |
| NCT06161688 | Placebo-Controlled, Randomized Trial of Ensitrelvir (S-217622) for Viral Persistence and Inflammation in People Experiencing Long COVID (PREVAIL-LC) | ACTIVE_NOT_RECRUITING | PHASE2 | Timothy Henrich | Patient-Reported Outcomes Measurement Information System (PROMIS)-29 Physical Health Summary Score | Patient-Reported Outcomes Measurement Information System (PROMIS)-29 Physical Health Summary Score; Patient-Reported Outcomes Measurement Information System (PROMIS)-29 Mental Health Summary Score; Patient-Reported Outcomes Measurement Information System (PROM |
| NCT05453201 | Developing an Integrative, Recovery-Based, Post-Acute COVID-19 Syndrome (PACS) Psychotherapeutic Intervention | COMPLETED | nan | VA Office of Research and Development | Change in Functional Improvement Post-COVID-19 Over Time | Change in Health-Related Functional Status Over Time; Change in Suicide Risk Over Time; Change in Self-perceived Status on Several Skills Over Time; Change in Identity Concerns Over Time; Change in Depression Over Time; Change in Anxiety Over Time; Change in Q |
| NCT05205460 | Effectiveness of a 12-week Telerehabilitation Training in People With Long COVID: A Randomized Controlled Trial | COMPLETED | nan | Tri-Service General Hospital | Change in Exercise Capacity: Peak Oxygen Uptake (VO2peak) From Baseline to 12 Weeks; Change in Exercise Capacity: Workload (Watt) From Baseline to 12 Weeks; Change in Exercise Capacity: Anaerobic Threshold (AT) From Baseline to 12 Weeks; Change in Lung Functio | Change in Physical Activity Amounts: Taiwan Version of the International Physical Activity Questionnaire From Baseline to 12 Weeks; Change in Confidence Level of Exercise: Questionnaire of Self-Efficacy Items From Baseline to 12 Weeks; Change in Health-Related |
| NCT05597722 | Randomized Study to Evaluate Strategies to Address Cognitive Fog in Long-COVID-19 Patients | TERMINATED | PHASE4 | Eva Szigethy | Change in Cognitive Impairment - MOCA; Change in Cognitive Impairment - BrainCheck; Change in Cognitive Impairment - ImPACT | Change in Depression - PHQ8; Change in Quality of Life - SWLS; Change in Disability |
| NCT04313972 | IC PaIN Trial: Interstitial Cystitis Pain Improvement With Naltrexone, the Effect of Low Dose Naltrexone on Symptoms and Pain of Patients With Interstitial Cystitis/Painful Bladder | TERMINATED | PHASE4 | Endeavor Health | Interstitial Cystitis Symptom Index; Visual Analog Scale | Change in Interstitial Cystitis Problem Index; Change in Urinary Frequency; Change in Number of Nocturia; Change in Pelvic Pain and Urgency/Frequency Symptoms; Change in Pelvic Pain and Urgency/Frequency Bother; Patient Perceived Quality of Life: SF-36; Advers |
| NCT05513560 | REcovering From COVID-19 Lingering Symptoms Adaptive Integrative Medicine (RECLAIM) | COMPLETED | PHASE2; PHASE3 | University Health Network, Toronto | SF-36 physical component score (PCS) | Symptoms scale; Symptom Checklist; Six Minute Walking Test (6MWT) with oximetry; TestMyBrain cognitive testing; Post COVID19 functional status scale; Reintegration to Normal Living Index (RNLI); Fatigue Scale; Brief Fatigue inventory; Post-Exertional Malaise; |
| NCT05638633 | Prednisolone and Vitamin B1, B6, and B12 in Patients With Post-COVID-19-Syndrome (PC19S) - a Randomized Controlled Trial in Primary Care | COMPLETED | PHASE3 | Wuerzburg University Hospital | Pilot phase: Proportion of participants retained after 28 days; Confirmatory phase: Mean difference in PROMIS Total Score from day 0 to day 28 | PROMIS total and subscores; Measure Yourself Medical Outcome Profile (MYMOP); Overall assessment of functional status; PC19 symptom list; EQ-5D-5L; visual analogue scale; PHQ 8; Chalder Scale; Numeric rating scale for pain; Testbatterie zur Aufmerksamkeitsprüf |
| NCT05795816 | The Effectiveness of Testofen on Energy, Fatigue, Mental Acuity, and Other Quality of Life Symptoms Post COVID-19 Infection | COMPLETED | PHASE3 | RDC Clinical Pty Ltd | Change in Energy and Fatigue; Change in Energy and Fatigue | Change in Memory; Change in Mental Acuity; Change in Muscle Strength (Hand grip); Change in Hair loss/growth; Change in Libido; Change in Stress and Mood; Change in Quality of Life Indicators; Change in Pathology results via Blood test; Change in Weight; Heigh |
| NCT06245642 | A Multi-center, Randomized, Double-blind, Positive Parallel Control Study of Compound Ciwujia Granules in the Treatment of Chronic Fatigue Syndrome (Spleen-kidney Deficiency Syndro | COMPLETED | PHASE4 | Heilongjiang Quanle Pharmaceutical Co., Ltd. | The subjects' Chalder scale scores changed after 3 and 6 weeks of treatment | Changes in Chalder scale scores and sub-scores; Changes in TCM syndrome scores and sub-scores; Changes in scores of EQ-5D-5L Quality of Life questionnaire |
| NCT05890534 | Pycnogenol® in People With Post-COVID-19 Condition: a Quadruple-blind, Randomized, Placebo-controlled Trial | COMPLETED | PHASE3 | University of Zurich | Health status (EQ-VAS) | Post COVID-19 symptoms; Fatigue; Dyspnea; Cognitive function; Anxiety and depression; Health-related quality of life (EQ-5D-5L); Functional exercise capacity; Physical activity; Soluble Thrombomodulin (sTM); von Willebrand Factor antigen (VWF:Ag); Syndecan-1; |
| NCT06383819 | Multicenter, Randomized, Double-blind, Placebo-controlled Parallel-group Study to Evaluate the Efficacy and Safety of Longidaza® for the Treatment of Patients With Residual Changes | COMPLETED | PHASE3 | NPO Petrovax | Change in Forced vital capacity (FVC) (visit 4) | Slowing the decline in respiratory function; Change in FVC (visit 5); The proportion of patients with an increase in the FVC (%); Dynamics of hemoglobin oxygen saturation (SpO2); The proportion of patients with SpO2 ≥ 93% and < 93%; The proportion of patien |
| NCT04997395 | Safety and Tolerability of Full Spectrum Cannabidiol Dominant Medicinal Cannabis in Treating Symptoms Associated With Long COVID: A Feasibility Study | COMPLETED | PHASE2 | Bod Australia | Recruitment rate; Tolerability for the treatment of long COVID; Number of side effects | Long COVID symptoms; Fatigue; Self-reported quality of life; Pain score; Mood (anxiety); Mood (depression); Sleep quality; Resting heart rate (expressed as average beats per minute); Activity levels (number of daily steps, distance walked, stairs climbed, acti |
| NCT05668091 | An Interventional Decentralized Phase 2, Randomized, Double-Blind, 2-Arm Study to Investigate the Efficacy and Safety of Orally Administered Nirmatrelvir/Ritonavir Compared with Pl | COMPLETED | PHASE2 | Harlan M Krumholz | National Institutes of Health (NIH) Patient-Reported Outcomes Measurement Information System (PROMIS)-29 version 2.1 Physical Health Summary Score | Modified General Symptom Questionnaire-30 (Modified GSQ-30); PROMIS® Cognitive Function v.2.0 - Short Form 6a; COVID Core Outcome Measure for Recovery; EuroQol EQ-5D-5L Utility Score-VAS (USA Version); Functional Assessment of Chronic Illness Therapy (FACIT)-I |
| NCT05619653 | Randomised Placebo Controlled Clinical Trial of Efficacy of MYOcardial Protection in Patients With Postacute inFLAMmatory Cardiac involvEment Due to COVID-19 | ACTIVE_NOT_RECRUITING | PHASE3 | Valentina Puentmann | Left ventricular ejection fraction | Scar burden by late gadolinium enhancement (LGE); Cardiopulmonary exercise testing (CPET); Mean T1 and T2 mapping; LV Volume (ml/m2) and LV mass (g/m2); LV strain %; Aortic stiffness (PWV); Aortic wall imaging (LGE); Average Symptom Score (Modified CCS, NYHA, |
| NCT04604704 | Pilot Study Into Low Dose Naltrexone (LDN) and Nicotinamide Adenine Dinucleotide (NAD+) for Treatment of Patients With Post-COVID-19 Syndrome (Long-COVID19) | COMPLETED | PHASE2 | AgelessRx | Reduction of fatigue in post-COVID-19 syndrome by treatment with LDN and NAD+ | Improvement of quality of life in post-COVID-19 syndrome by treatment with LDN and NAD+. |
| NCT05823896 | An Interventional, Double-Blinded, 2-Arm Study to Investigate the Efficacy of Orally Administered Nirmatrelvir/Ritonavir Compared with Placebo/Ritonavir in Non-hospitalized Adult P | COMPLETED | PHASE2 | Karolinska Institutet | Change from baseline in quality of life over time | Change from baseline in quality of life over time; Change from baseline in hemodynamic response over time; Change from baseline in dysautonomia over time; Change from baseline in fever in patients with POTS over time; Change from baseline in endothelial functi |
| NCT04842448 | Hyperbaric Oxygen for Treatment of Long COVID Syndrome; A Randomized, Placebo-Controlled, Double-Blind, Phase II Clinical Trial | COMPLETED | PHASE2 | Karolinska University Hospital | RAND 36 change | Endothelial dysfunction; 6-min walk test; 30/60 min chair stand; EQ-5D; RAND 36 normalization |
| NCT05430152 | A Double Blind Randomized Trial of Low-dose Naltrexone for Post-COVID Fatigue Syndrome | COMPLETED | PHASE2 | Luis Nacul | Fatigue Intensity | Pain Severity; Symptom Severity; Activity Levels; Self-reported Quality of Life |
| NCT05497089 | Temelimab as a Disease Modifying Therapy in Patients With Neurological, Neuropsychological, and Psychiatric (=Neuropsychiatric) Symptoms in Post-COVID 19 or Postacute Sequelae of C | COMPLETED | PHASE2 | GeNeuro SA | Improvement in fatigue in PASC patients | Fatigue; Cognitive function; Cognitive function; Cognitive function; Cognitive function; Anxiety; Depression; Overall quality of Life; Functional impairment; Post-COVID-19 Functional Status; Safety and tolerability of Temelimab in PASC patients |
| NCT05445674 | Plasma Exchange Therapy for Post- COVID-19 Condition: A Pilot, Randomized Double-Blind Study | COMPLETED | PHASE2 | Fundación FLS de Lucha Contra el Sida, las Enfermedades Infecciosas y la Promoción de la Salud y la Ciencia | Evaluate the safety and tolerability of PE in patients with Post-Acute Covid-19 Syndrome (PCC) comparing to sham plasma exchange (placebo); Proportion of subjects with Grade 0, 1 o 2 functional disability assessed by the functional status scale (PCFS); Proport | Assess the ability of PE to improve PCC symptoms; Assess the impact of PE on quality of life in subjects with PCC; Assess the impact of PE on quality of life in subjects with PCC using MOS-HIV questionnaire; Assess the impact of PE on neurocognitive symptoms i |
| NCT06840873 | Effectiveness of a 8-week Tele-Rehabilitative Exercise Training Program on Fatigue, Symptom Severity, and Quality of Life in Nurses With Long COVID: A Randomized Controlled Trial | COMPLETED | nan | Shang-Lin Chiang | Fatigue (score); O2 pulse in ml/beat; Aerobic capacity (VO2 max in ml/kg/min ); Working load in watt; Heart rate recovery in beat/min; Anaerobic threshold (AT in ml/kg/min); Severity of long COVID symptoms (scores) | Quality of life (scores); Perceived stress (scores) |
| NCT06404073 | RECOVER-ENERGIZE: A Platform Protocol for Evaluation of Interventions for Exercise Intolerance in Post-Acute Sequelae of SARS-CoV-2 Infection (PASC) | COMPLETED | nan | Duke University | Change in frequency of PEM symptoms, as measured by the Modified DePaul Symptom - Post-Exertional Malaise questionnaire (mDSQ-PEM); Change in severity of PEM symptoms, as measured by the Modified DePaul Symptom - Post-Exertional Malaise questionnaire (mDSQ-PEM | Change in PASC symptoms, as measured by the PASC Symptom Questionnaire; Change in PASC symptoms, as measured by the PROMIS-Cog Questionnaire; Change in quality of life, as measured by the PROMIS-29+2; Change in quality of life, as measured by the EQ-5D 5L; Cha |
| NCT06721949 | Taurine Supplementation as a Novel Therapeutic Approach for Neurocognitive Symptoms in Long COVID | RECRUITING | PHASE2; PHASE3 | University of Alberta | Mean change in Modified Fatigue Impact Scale (MFIS) from baseline to three months; Mean change in the ratio of the Trail-Making Tests A & B in the TestMyBrain cognitive testing battery from baseline to three months. | Core Outcome Set - Symptoms; Cardiovascular function; Respiratory function; Cognitive Function; Memory; Concentration; Conceptual Thinking; Social Functioning; Mental Health Status - PHQ-9; Mental Health Status - GAD-7; Post-Exertional Malaise (PEM) Symptoms; |
| NCT06974058 | Evaluation of a Quercetin/Curcumin-Based Supplement for Mild to Moderate Long COVID-19 Symptoms: A Pragmatic, Interventional Clinical Study. | COMPLETED | nan | Liaquat University of Medical & Health Sciences | Change in Overall Symptom Burden | Change in Functional Status and Quality of Life (SF-36 Scores); Change in the Need for Prescribed Medications or NSAIDs (Non-Steroidal Anti-Inflammatory Drugs); Change in Pain Severity and Pain Interference (Brief Pain Inventory - Short Form); Change in Fatigu |
| NCT05857124 | A Pilot Study Evaluating the Efficacy of the Vielight Neuro RX Gamma in the Treatment of Post COVID-19 Cognitive Impairment | COMPLETED | PHASE1 | Vielight Inc. | The change in the combined results of 7 Creyos items: Spatial Planning, Monkey Ladder, Rotations, Feature Match, Paired Associates, Token Search, Polygons. | Creyos scores of the 5 remaining tests (i.e. Grammatical Reasoning, Spatial Span, Digit Span, Odd One Out, Double Trouble); EQ-5D-5L Quality of Life; Fatigue Assessment Scale (FAS); The perceived deficits questionnaire - 20 item version (PDQ-20); Compliance an |
| NCT05218174 | Exercise Training and Functional, Cognitive, and Emotional Well-being in Adults with Post-Acute Sequelae of SARS-CoV-2 (COVID-19) Infection (PASC): a Randomized Controlled Trial | COMPLETED | nan | Baylor Research Institute | Peak Oxygen Consumption (VO2max), mL/min; Peak Oxygen Consumption (VO2max), mL/min; Peak Oxygen Consumption (VO2max), mL/min; Score on Cognitive Function Self-Assessment Scale (CFSS); Score on Cognitive Function Self-Assessment Scale (CFSS); Score on Cognitive | Duration, mm:ss; Duration, mm:ss; Duration, mm:ss; Peak VO2 (absolute), mL/min; Peak VO2 (absolute), mL/min; Peak VO2 (absolute), mL/min; Peak VO2 (relative), mL/kg/min; Peak VO2 (relative), mL/kg/min; Peak VO2 (relative), mL/kg/min; Metabolic Equivalents; Met |
| NCT06315894 | Design and Implementation of a Supervised Computerized Active Program (SuperCAP) for Improvement of Cognitive, Emotional, and Functional Status in People With Post-COVID Syndrome. | COMPLETED | nan | Fundación FLS de Lucha Contra el Sida, las Enfermedades Infecciosas y la Promoción de la Salud y la Ciencia | Change in Self-reported Cognitive Functioning | Change in Performance-based Cognitive Functioning; Change in Depression Symptoms; Change in Anxiety Symptoms; Change in Daily Activities Functioning; Change in Physical Activity; Change in Quality of Life |
| NCT05216549 | Water and Land-based Exercise for Children With Post COVID-19 Condition | COMPLETED | nan | Józef Piłsudski University of Physical Education | Exercise capacity; Fatigue | Health-related quality of life; Forced vital capacity (FVC); Forced expiratory volume/one second (FEV 1); Maximal expiratory flow at 25% of forced vital capacity (MEF25) |
| NCT06330376 | Diaphragmatic Breathing Exercises for Post-COVID-19 Diaphragmatic Dysfunction (DD) | COMPLETED | nan | University of Minnesota | 6-minute walk test (6MWT) | PHQ9: Patient health questionnaire 9; GAD7: Generalized anxiety disorder 7-item; PROMIS score: Patient-Reported Outcomes Measurement Information System; QoL scale: Quality of life scale; FACIT fatigue scale 's Fatigue score; Modified Borg dyspnea scale; R |
| NCT05024474 | Effects of Inspiratory Muscle Training After Covid-19 | COMPLETED | nan | Karolinska Institutet | Change in Maximal Inspiratory Pressure (MIP) | Change in Maximal Expiratory Pressure (MEP); Change in Lung function; Change in walking distance during 6 minute walk test, expressed as percentage of predictive value,; Change in oxygen saturation during 6 minute walk test; Change in oxygen desaturation durin |
| NCT06952127 | Pilot Study Evaluating the Feasibility and Appropriateness of a Telerehabilitation Exercise Program in People With Post-COVID-19 Sequelae: a Single-center Randomized Trial. | COMPLETED | nan | Centre intégré universitaire de santé et de services sociaux de la Mauricie-et-du-Centre-du-Québec | The feasibility of study procedures | Exercise capacity; Walking capacity; Lower-limb endurance; Physical performance; Change in Independence in activities of daily living; Change in Clinical Frailty; Change in Quality of life |
| NCT05710770 | Double-blinded, Randomized, Sham-controlled Trial of Immunoadsorption (IA) in Patients With Chronic Fatigue Syndrome (CFS) Including Patients With Post-acute COVID-19 CFS (PACS-CFS | COMPLETED | nan | Charite University, Berlin, Germany | Improvement in physical and mental fatigue as measured by the Chalder Fatigue Scale | Sustained improvement quantified by the Chalder Fatigue Scale; Verification of safety and tolerability of immunoadsorption in this patient population; Improvement in severity of symptoms of chronic fatigue syndrome (CFS) as measured by the Fluge score; Improve |
| NCT05244044 | Changes in Functional Exercise Capacity After PUlmonary REhabilitation in Primary Care: a Randomized, Controlled, Multicenter, Pragmatic Trial in 134 Patients With Long COVID (PuRe | COMPLETED | nan | University Hospital, Antwerp | Exercise capacity | Change in physical activity; Change in COVID-19 related symptoms; Change in quality of life; Change in fatigue; Change in dyspnoea; Change in functional status; Change in work productivity and activity impairment.; Change in anxiety and depression symptoms.; C |
| NCT05630378 | Evaluation of a Multimodal Integrative Medicine and Naturopathy Program in an Outpatient Setting With Focus on Mind-Body Medicine and Mild Water-filtered Infrared-A Whole-body Hype | COMPLETED | nan | Universität Duisburg-Essen | Fatigue - Change from week 0 to week 11 | Quality of life 1; Hospital Anxiety and Depression; Perceived Stress; perceived Pain; Quality of life 2; Sleep Quality; Resilience |
| NCT05273372 | A Randomized Double Blind Placebo Controlled Trial to Determine the Effects of Oxaloacetate on Improving Fatigue in ME/CFS | COMPLETED | nan | Terra Biological LLC | Reduction of Fatigue | Number of participants with treatment-related adverse events as assessed by CTCAE v4.0; Physical Functioning on the SF-36; Patient Global Impression of Change Questionnaire, 7 point scale, -3 to +3, with the higher score indicating more improvement |
| NCT07508332 | Lung Boost Trainer Versus Incentive Spirometer on Spiro-metric Indices in Post COVID-19 Hemiplegic Cerebral Palsy Children; Randomized Controlled Trial | COMPLETED | nan | Cairo University | Pulmonary function test (PFT) :; forced vital capacity (FVC%); Forced expiratory volume (FEV1%):; FEV1/FVC ratio : | Six-minute walk test (6MWT); Short form 36 (SF-36) |
| NCT06814379 | Rehabilitation of Fatigue in Patients With Post-COVID-19 Syndrome | COMPLETED | nan | Universidad de Granada | Perceived Fatigue; Multidimensional Fatigue; Fatigue Severity; Fatigue Impact | COVID-19 information; Comorbidities; Dyspnea. The Borg Modified Scale; Dyspnea. Dyspnea-12; Dyspnea. Modified Medical Research Council (mMRC) Dyspnea Scale; Pain intensity; Psychological status; Sleep quality; Health-related Quality of life; Functional status: |
| NCT05373407 | A Randomized Controlled Trial Examining the Impact of Low Versus Moderate-intensity Aerobic Training in Post-discharge COVID-19 Older Subjects | COMPLETED | nan | University of Hail | Distance walked in the 6-min walk test (6 MWT); Post-Covid Functional Scale (PCFS) | Number of repetitions performed in a 1-min Sit-to-Stand (STS) test; 2. Anxiety and Depression evaluated by the HAMLITON ScAnxiety and Depressionale (HADS); Quality of life SF-36 |
| NCT05699538 | Fatigue and Fatigability in Veterans Following SARS-CoV-2 Infection | COMPLETED | nan | VA Office of Research and Development | Performance fatigability | Rating of Perceived Fatigue (RPF); Isometric and Isokinetic Knee Extensor Torque; Skeletal muscle oxygen extraction; Feeling Scale; Fatigue Severity Scale (FSS); Short Physical Performance Battery (SPPB); 30-second sit-to-stand; Six Minute Walk Test (6MWT); Mo |
| NCT05798221 | Complementary Self-help Strategies for Patients With Post-COVID-19 Syndrome: A Randomized Controlled Trial | COMPLETED | nan | Universität Duisburg-Essen | Post-COVID-19 symptom burden | Post-COVID-19 symptom burden; Post-COVID-19 functional status (self-reported); Post-COVID-19 functional status (self-reported); Health-related quality of life; Health-related quality of life; Fatigue; Fatigue; Anxiety and depression; Anxiety and depression; In |
| NCT05697640 | A Parallel-group Treatment, Phase 2a, Double-blind, Placebo-controlled 2-arm Study to Show Improvement of Physical Function in SF-36 (SF-36-PF) in Participants Treated With Vericig | ACTIVE_NOT_RECRUITING | PHASE2 | Charite University, Berlin, Germany | Improvement in Physical Function (PF) as measured by the Short Form 36 Health Survey Questionnaire (SF-36) | Difference in responder rate in Physical Function (PF) as measured by the Short Form 36 Health Survey Questionnaire (SF-36) comparing Vericiguat with placebo; Improvement in other sub-domains of the Short Form 36 Health Survey Questionnaire (SF-36) comparing V |
| NCT04751669 | Efficacy of Micronutrient Dietary Supplementation in Reducing Hospital Admissions for COVID-19: A Double-blind, Placebo-controlled, Randomized Clinical Trial | COMPLETED | nan | Fundació Institut Germans Trias i Pujol | Need for hospital admission; Incidence of Long Covid. | Micronutrient basal status (Vitamin B1, Vitamin B6, 25-OH-Vitamin D and Folic Acid; Micronutrient basal status (Vitamin B12); Micronutrient basal status (Iron, Zinc and Copper ); Micronutrient basal status (Vitamin A and Vitamin E); Micronutrient basal status |
| NCT05139979 | Yogic Breathing and Guided Meditation for Long Covid Symptoms | COMPLETED | nan | Beth Israel Deaconess Medical Center | Compliance | Perceived Stress Scale (PSS); Profile of Mood States (POMS); Quality of Life Survey (SF12); Multidimensional Dyspnea Profile (MDP); Somatic Symptom Scale 8 Items (SS8); Qualitative Assessments |
| NCT04603157 | Remote Self-training Program for Patients With Postural Orthostatic Tachycardia Syndrome (POTS) | COMPLETED | nan | Mayo Clinic | Change Peak Oxygen consumption at 3 months | Change in Composite Autonomic Symptom Score (COMPASS 31) at 3 months; Change in Functional Ability Score at 3 months; Change in 36-Item Short Form Health Survey questionnaire (SF-36) at 3 months; Change in heart rate with 10-min Stand test at 3 months; Change |
| NCT05032885 | RANDOMIZED CLINICAL TRIAL OF PHYSIOTHERAPY IN COVID PATIENTS ON THEIR PHYSICAL CONDITIONING, ANXIETY LEVEL AND THEIR QUALITY OF LIFE | COMPLETED | nan | Hospital Universitario Getafe | Respiratory competence; Motor competence | Anxiety state; Variation in the level of quality of life |
| NCT06054438 | Examining the Immunomodulatory and Health Improving Function of a Chinese Medicine Nutritional Supplement Cs4 on Immunity-related Disorders in the Post-COVID Era | COMPLETED | nan | The University of Hong Kong | the change in symptom severity from 0 to 12 weeks measured by the modified COVID-19 Yorkshire Rehabilitation Scale (C19-YRSm) | the change in Insomnia Severity Index (ISI) from 0 to 12 weeks; the change in Brief Fatigue Inventory Form (BFI) from 0 to 12 weeks; the change in St. George's Respiratory Questionnaire (SGRQ) from 0 to 12 weeks; the change in Hospital Anxiety and Depress |
| NCT05836402 | Low-Carbohydrate Dietary and Lifestyle Interventions for the Management of Long COVID-19 Syndrome: A Prospective and Interventional Randomized Controlled Pilot Study | COMPLETED | nan | University of Southern California | Feasibility of dietary intervention:; Safety signals for electrolytes; Safety signals for kidney function; Safety signals for liver function; Cardiovascular risk; Improved uric acid metabolism; kidney function: proteinuria; Safety and tolerability of dietary i | Improvement of long-COVID syndrome signs Measurement of change in body weight; Improvement of long-COVID syndrome signs Measurement of aerobic capacity:; Improvement of long-COVID syndrome signs: Measures of inflammation; Improvement of long-COVID syndrome sig |
| NCT06189118 | Online Mindfulness-Based Cognitive Therapy vs Health Enhancement Program for Depressive Symptoms in Older Adults: a Randomized Controlled Trial | COMPLETED | nan | Lady Davis Institute | Depressive symptoms scores | Quality of Life scores; Processing Speed; Executive Functioning |
| NCT05532904 | Evaluation and Comparison of Multidisciplinary Day-hospital Versus Waiting List Management of Persistent Symptoms After an Acute Episode of COVID-19 | COMPLETED | nan | Assistance Publique - Hôpitaux de Paris | Quality of life | Quality of life; Fatigue; Dyspnea; Cognitive complaint; Pain; Patient's satisfaction; Physical fitness; Post-effort heart rate; Weight loss; BMI; Blood albumin; Nutritional risk; Health beliefs associated with persistent symptoms |
| NCT06960928 | Low Dose Sirolimus in People With Post-Acute Sequelae of COVID-19 (PASC) Long COVID-19 | RECRUITING | PHASE3 | Icahn School of Medicine at Mount Sinai | European Quality of Life-Visual Analogue Scale (EQ-VAS) | The EuroQol Five-Dimensional Health Questionnaire (EQ-5D-5L); Patient-Reported Outcomes Measurement Information System 29 (PROMIS-29); General Symptom Questionnaire (GSQ-30); Patient Health Questionnaire (PHQ-9); Generalized Anxiety Disorder (GAD-7); Neuro-QoL |
| NCT06016192 | Medical Rehabilitation of Patients With Long-term Post-Covid-19 Syndrome - a Comparison of Aerobic Interval and Continuous Training | COMPLETED | nan | University of Witten/Herdecke | Change in Cardiorespiratory Fitness (CRF) | Change in Submaximal Cardiorespiratory Fitness (CRF); Change in Fatigue; Work requirements and workload; Change Health-related quality of life; Wellbeing; Change in Depression and Anxiety |
| NCT05922865 | Tri-service General Hospital, National Defence Medical Center, Taipei, Taiwan | COMPLETED | nan | Shang-Lin Chiang | Aerobic capacity (VO2 max in ml/kg/min ); Anaerobic Threshold (mL/kg/min); Working load in watt; Breathing reserve (ml/kg/min); Rest Heart rate in beat/min; O2 pulse in ml/beat; Systolic blood pressure in mm Hg; Diastolic blood pressure in mm Hg; VE/VCO2 slope | Quality of life (scores); Sleeping Quality (scores); Body composition: Body weight (kg); Body composition: Body fat (%); Body composition: Lean mass weight (kg) |
| NCT03105713 | Development and Implementation of Surgical Safety Checklists for Patients to Use Before Admission, Before Discharge and After Discharge (PASC) - a Stepped Wedge Cluster Randomized | COMPLETED | nan | Haukeland University Hospital | Number of complications associated with the participants surgery; Number of complications within respiratory system; Number of complications within cardio-thoracic system; Number of infections; Number of nervous system complications; Volume of bleeding associa | Number of deaths associated with surgery; Rate of patient scores on Health Literacy Questionaire; Rate of patient scores on EQ5D; Rates of Checklist Implementation Survey scores |
| NCT05715554 | Community-based Individualized Homeopathic Rehabilitation in Post COVID-19 Patients: Results of a Pilot, Pragmatic, Randomized, Open Label, Controlled Trial Investigating Acceptabi | COMPLETED | nan | Innowage Limited | Cough severity | Change in dyspnea; Change in Fatigue; change in Quality of Life |
| NCT05402007 | Clinical and Functional Effects of Supervised and Unsupervised Cardiopulmonary Rehabilitation in POST-COVID-19 Syndrome: Clinical and Randomized Trial | COMPLETED | nan | Centro Universitário Augusto Motta | Peripheral muscle function I; Peripheral muscle function II; Peripheral muscle function III; Daily living activity | Quality of life improvement |
| NCT05252481 | Modulation of Post-COVID-19 Fatigue Using Transcranial Direct Current Stimulation. Transcranial Direct Stimulation for Persistent Fatigue Treatment Post-COVID-19 | COMPLETED | nan | Hospital San Carlos, Madrid | Change in Fatigue | Change in cognition; Change in depressive symptoms; Change in quality of life |
| NCT06723821 | Effectiveness of Noninvasive Neuromodulation in Post-COVID Musculoskeletal Pain in the Short Term: Randomized Clinical Trial | COMPLETED | nan | University of Alcala | Visual Analogue Scale (VAS) | DN4 scale; Pittsburg Sleep Quality Index score; Hospital Anxiety and Depression Scale (HAND); Quality of life SF12 |
| NCT05732285 | A Pilot Randomized Controlled Trial of A Comprehensive Cognitive and Affective Intervention for Neurocognitive Disorders (CoINTEGRATE) | COMPLETED | nan | University of Michigan | Number of patients that complete the study; Average number of sessions completed; Overall experience based qualitative semi-structured interview | The Community Integration Questionnaire (CIQ) Score; The Short Form Health Survey (SF-36); Montreal Cognitive Assessment (MoCA); The Symbol Digit Modalities Test Score (SDMT-5 minutes); Brief Visuospatial Memory test (BVMT-R-25 minutes); California Verbal Lear |
| NCT04741841 | Effect of Probiotic Food Supplement "GutMagnific™" in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS), Also Known as Post-viral Fatigue Syndrome, and Comorbid | COMPLETED | nan | ImmuneBiotech Medical Sweden AB | Changes in ME/CFS symptoms | Changes in Irritable Bowel Syndrome (IBS) symptoms; Changes in the gastrointestinal symptoms based on Rome III criteria; Changes in health related quality of life (RAND 36-Item Health Survey); Changes in Hospital Anxiety and Depression Scale (HADS); Changes in |
| NCT05254301 | Faster Functional Performance Recovery After Individualized Nutrition Therapy Combined With a Patient-tailored Physical Rehabilitation Program Versus Standard Physiotherapy in Pati | COMPLETED | nan | Universitair Ziekenhuis Brussel | 1-minute sit-to-stand (1-MSTS) | Multi-dimensional Fatigue Inventor (MFI-20); EuroQol five-dimensional (five-level version) (EQ-5D-5L); Post-COVID-19 Functional Status (PCFS); Hospital Anxiety and Depression Scale (HADS); Work Productivity and Activity Impairment (WPAI) |
| NCT06980636 | Shengmai Liquid for Long COVID Fatigue: a Randomized Placebo-controlled Trial. | RECRUITING | PHASE4 | Beijing University of Chinese Medicine | The degree of improvement in patient fatigue, measured using the Modified Fatigue Impact Scale (MFIS) | Traditional Chinese Medicine Syndrome Score Scale; Improvement in depression, assessed using the 17-item Hamilton Depression Scale; Improvement in anxiety, assessed using the Hamilton Anxiety Scale (HAMA); Improvement in sleep quality, assessed using the Pitts |
| NCT05453175 | The Effect of Uninterrupted and Interrupted Sitting on Vascular Health and Cognitive Function in People with Long COVID-19 | COMPLETED | nan | University of Winchester | Pulse Wave Velocity | Central and peripheral pulse wave analysis; Cognitive function; Quality of Life - EuroQuol 5 Dimensions 5 levels (EQ-5D-5L) |
| NCT05454137 | Postural Orthostatic Tachycardia Syndrome: a Pilot, Feasibility Study of an Integrative Shared Medical Appointment Intervention | COMPLETED | nan | University of Arizona | Recruitment and retention rate | Change in COMPASS overall score; Change on Short Form Survey (SF-36) overall score |
| NCT04794036 | Efficacy of an Asynchronous Telerehabilitation Programme in Post-COVID-19 Patients: a Feasibility Study | COMPLETED | nan | Universidad San Jorge | Fatigue Severity Level | Adherence; Engagement; Satisfaction level; Incidents; Maximum Leg Strength Endurance; Maximum Arm Strength Endurance; Submaximum Aerobic Capacity Walking; Post-COVID Functional Status; Depression, Anxiety and Stress; Self-efficacy; Behavior in sport; Perceived |
| NCT04718506 | Rehabilitation for Post-COVID-19 Syndrome Through a Multicomponent, Educational and Supervised Exercise Intervention [RECOVE] | COMPLETED | nan | Universidad de Murcia | Changes in subject clinical status | Changes in cardiovascular fitness: Maximal oxygen consumption (VO2max); Changes in neuromuscular performance during resistance exercise: Barbell Mean Propulsive Velocity (MPV); Changes in balance: center of pressure (COP) sway; Changes in pulmonary function: F |
| NCT05422924 | A Pilot and Feasibility Study of a Web-based Platform to Improve Physical Function, Nutrition, and Mindfulness in Patients With Long COVID | COMPLETED | nan | University of Alberta | Feasibility (defined by recruitment, adherence, and retention). | Changes in quality of life parameters; Changes in fat mass; Changes in lean mass; Changes in muscle cross sectional area; Changes in dietary intake; Changes in mindfulness with Mental health questionnaire from the Symptom Burden Questionnaire for Long COVID; C |
| NCT04158427 | Intestinal Microbiota and Chronic Fatigue Syndrome. Effect of Fecal Transplant on Health Related Quality of Life of the Patients With Chronic Fatigue Syndrome | COMPLETED | nan | Tampere University Hospital | Health related quality of life assessed by EQ-5D-5L questionnaire; Health related quality of life assessed by 15D questionnaire; Health related quality of life assessed by Modified Fatigue Impact Scale; Ability to work or study; Visual Analog Fatigue Scale | Health related quality of life assessed by EQ-5D-5L questionnaire; Health related quality of life assessed by 15D questionnaire; Health related quality of life assessed by Modified Fatigue Impact Scale; Ability to work or study; Visual Analog Fatigue Scale |
| NCT06503913 | Cognitive Muscular Therapy for Patients With Long-COVID (Post COVID-19) and Breathing Pattern Disorder | COMPLETED | nan | University of Salford | Change in Nijmegen Questionnaire | Change in Modified COVID-19 Yorkshire Rehabilitation Scale (C19-YRSm) scale; Change in Dyspnea-12 questionnaire; Change in Self-evaluation of breathing questionnaire; Change in Composite Autonomic Symptom Score; Change in EQ-5D-5L; Change in WHO Disability Ass |
| NCT06172803 | RESToRE: Restoring Energy With Sub-symptom Threshold Optimized Rehabilitation Exercise for Long COVID | COMPLETED | nan | Columbia University | Number of participants who enrolled; Number of participants who completed; Number of participants who adhered to session attendance | PROMIS-29 scale score; Rand 36-Item Health Survey (SF-36) score; VO2 % predicted from Cardiopulmonary Exercise Testing (CPET); Number of participants with orthostatic hypocapnia.; EuroQol: Education Quotient-5D Visual Analogue Scale score; General Symptom Ques |
| NCT05231512 | The Effects of a Music Therapy Respiratory Protocol on Post-Covid Respiratory Symptoms | COMPLETED | nan | Icahn School of Medicine at Mount Sinai | MRC dyspnea score | Self-reported Chronic Respiratory Questionnaire (CRQ-SR); Visual Analog Scale (VAS); Beck Depression Inventory - short form (BDI-SF); General Anxiety Disorder 7-item questionnaire (GAD-7); Hospital Anxiety and Depression Scale (HADS); Coronavirus Anxiety Scale |
| NCT06064838 | Effects of Cacao Flavonoids in Long COVID-19 Patients with Chronic Fatigue (FLALOC) | COMPLETED | nan | Guillermo Ceballos Reyes | Interleukin-1b; Interleukin-6; TNF-alpha; Syndecan-1 | EQ-5D questionnaire; Analog Visual Scale; Numerical fatigue rating scale; Handgrip strength |
| NCT06017232 | The ParkinSANTÉlé Study: A Multicomponent Telerehabilitation Program to Improve Cardiovascular Health in People With Parkinson's Disease With a Clinical Diagnosis of Dysautono | COMPLETED | nan | Université de Sherbrooke | Feasibility of the implementation; Acceptability; Dysautonomia Symptoms; Impact of dysautonomia symptoms; Exercise capacity | Severity of pain and impact on functioning; Type of pain; Perceived quality of life; Lower-limb function; Mobility in the community; Mobility; Balance; Walking capacity; Lower-limb strength and power; Cardiovascular health; Sympathetic nervous innervation of t |
| NCT04657484 | Comparison of the Efficacy and Safety of Two Corticosteroid Regimens in the Treatment of Diffuse Lung Disease After Coronavirus Disease 2019 (COVID-19) Pneumonia | COMPLETED | nan | Post Graduate Institute of Medical Education and Research, Chandigarh | Proportion of subjects with a complete radiologic response | Proportion of subjects with a complete or good response radiologic response; Proportion of subjects with a good composite response; Forced vital capacity as a percentage of the predicted; Change in resting oxygen saturation; Proportion of subjects with oxygen |
| NCT04827992 | Evaluation of Medical Cannabis and Prescription Opioid Taper Support for Reduction of Pain and Opioid Dose in Patients With Chronic Non-Cancer Pain | COMPLETED | nan | Massachusetts General Hospital | Mean Difference in Prescription Monitoring Program verified opioid dose at baseline and week 24; Mean Difference in Pain, Enjoyment, General Activity (PEG) Scale Summed Score over post-baseline to week 24 interval | Mean Difference in Quality of Life Enjoyment and Satisfaction Questionnaire - Short Form Summed Score at weeks 4, 8, 12, 16, 20, 24; Mean Difference in PROMIS-29 Depression Subscale Summed Score at weeks 4, 8, 12, 16, 20, 24; Mean Difference in PROMIS-29 Anxie |
| NCT05732571 | Post COVID REspiratory Mechanisms and the Efficacy of a Breathing Exercise Intervention for DYsregulated Breathing (REMEDY): COVID-19 | COMPLETED | nan | University of Nottingham | Breathlessness.; Function | Dyspnoea-12 Questionnaire; Nijmegen Questionnaire; Borg Scale of Breathlessness; Four metre Gait speed; Modified Minnesota Physical Activity; Capnography - in some volunteers; Chalder Fatigue Score; EQ5D Quality of Life score; Adherence; Breath hold, Respirato |
| NCT05961462 | Effects of Exercise Training on Patients With Long COVID-19, a Single-center, Randomized, Controlled Study | COMPLETED | nan | Guangdong Provincial People's Hospital | Symptom improvement | Peak oxygen uptake; Quality of life measured by 12-Item Short Form Health Survey (SF12); Anxiety measured by Generalized Anxiety Disorder 7-item scale (GAD-7); Depression measured by Patient Health Questionnaire 9-item scale (PHQ-9); Insomnia measured by Insom |
| NCT06643299 | PURE-LC - Probiotic Use for Recovery Enhancement From Long COVID | ACTIVE_NOT_RECRUITING | PHASE2 | Rush University Medical Center | Difference in Long COVID Severity | Difference in LC-SSS Total Score; Difference in Quality of Life; Difference in Return to Work and Activity |
| NCT05204511 | Exercise and Post-COVID/Long-COVID: Effects of Different Training Modalities on Physical Performance, Heart Rate Variability, Inflammation, Health-Related Quality of Life, Cognitiv | COMPLETED | nan | University of Vienna | Change of peak oxygen consumption (VO2peak measured in ml/min/kg) | Change of maximum lower body isometric muscle strength (measured in N); Change of maximum hand grip strength (measured in kg); Change of Standard Deviation of RR-Intervals (SDNN measured in ms); Change of Root Mean Square of Successive Differences (RMSSD measu |
| NCT07128082 | The Long COVID Treatment Trial | ACTIVE_NOT_RECRUITING | PHASE2 | Scripps Translational Science Institute | Primary Objective 1: Changes in fatigue severity score, measured by Fatigue Severity Scale (FSS) | Secondary Outcome: Changes in overall health, measured by European Quality of Life 5 day, 5 level (EQ-5D-5L) scores; Secondary Outcome: Presence of and changes in post-exertional malaise, a condition that occurs in subsets of Long COVID and IACIs, measured by |
| NCT06847191 | A Double-blind, Randomized Study to Evaluate the Efficacy and Safety of Bezisterim (NE3107) in Adults With Long COVID | ACTIVE_NOT_RECRUITING | PHASE2 | BioVie Inc. | Change from Baseline in performance on the Cogstate Cognition battery* | Change from Baseline in PROMIS Cognitive Function Short Form 8a (SF-8a); Change from Baseline in PROMIS Fatigue Short Form 13a (SF-13a); Change from Baseline in PROMIS Sleep Disturbance Short Form 8a (SF-8a); Change from Baseline in SF-12 Health Survey (Physic |
| NCT04301609 | Randomized, Comparative, Double-blind, and Placebo-controlled Clinical Trial to Assess the Improvement of Fatigue, Sleep, Anxiety / Depression, Neurovegetatives Alterations and Qua | COMPLETED | nan | Vitae Health Innovation | Perception of fatigue (FIS-40). | Sleep dysfunction (Pittsburg questionnaire); Hospital anxiety-depression scale (HAD); Quality of life (SF-36) |
| NCT05752331 | Feasibility of Personalised Health Behaviour Coaching to Support Symptoms and Activities of Daily Living in Those With Long COVID-19. | COMPLETED | nan | Bournemouth University | Participant recruitment; Participant randomisation; Participant completion; Participant acceptability | Objective physical activity; Exercise capacity; Muscular strength and endurance; Lung Function; Health related quality of life; Breathlessness; Fatigue; Anxiety and Depression; Cognitive impairment |
| NCT05846126 | Digital Rehabilitation With Cognitive Training, Physical Activity and Mindfulness for People With Post-acute COVID-19 Syndrome With Cognitive Impairment. REHABCOVID Project. | COMPLETED | nan | Consorci Sanitari de Terrassa | Differences between groups in scores of global cognition; Differences between groups in scores of selective attention, inhibition, and processing speed; Differences between groups in scores of Visual scanning and processing speed; Differences between groups in | Differences between groups in scores of anxiety; Differences between groups in scores of depression; Differences between groups in scores of Mindfulness levels; Differences between groups in scores of Fatigue; Differences between groups in scores of psychologi |
| NCT05298878 | Virtual Physical Rehabilitation for Patients Living with Long COVID | COMPLETED | nan | McGill University Health Centre/Research Institute of the McGill University Health Centre | Change in the basic mobility domain of the Activity Measure for Post-Acute Care (AM-PAC) | Change in lower-body strength; Change in functional mobility; Change in fatigue; Change in dyspnea; Change in health-related quality of life; Change in health state utilities; Change in anxiety and depression; Change in cognitive function; Change in the degree |
| NCT06296914 | Developing and Testing a Mobile Health System for Patients with Postural Orthostatic Tachycardia Syndrome (POTS) | COMPLETED | nan | Jami Warren | Change in POTSapp Usability as measured by uMARS; Change in POTSapp Usage - number of page views; Change in POTSapp Usage - time spent in app; Change in POTSapp Usability as measured by Health-ITUES; Change in POTSapp Effectiveness as measured by Message Effec | Change in Participant Quality of Life; Change in Doctor Patient Communication (DPC); Adapted IBS Perceived Stigma Scale; Cognitive Learning |
| NCT04797871 | Resistance Training Intervention on the Clinical Status in Patients With Post Discharge Symptoms After Covid-19: The "EXER-COVID Study" | COMPLETED | nan | Universidad Pública de Navarra | Changes in Cardiorespiratory fitness | Changes in Post-COVID manifestations; Changes in Blood samples analysed for markers related to low grade inflammation; Changes in pulse wave velocity; Changes in cardio-ankle vascular index (CAVI); Changes in Energy expenditure; Changes in bone mineral density |
| NCT04996212 | Study of the Effectiveness of a Cardiorespiratory Telerehabilitation Program in Persistent COVID-19 Patients. Randomized Clinical Trial. | COMPLETED | nan | University of Valencia | Quality of life (EQ-5D-5L) | Quality of life (EQ-5D-5L) Change from Baseline PostCovid-19 Functional Satatus Scale at five months (PCFSS); Fatigue Assessment Scale (FAS); London Chest Activity of Daily Living Scale (LCADL); Hospital Anxiety and Depression Scale (HADS); Perceived Stress Sc |
| NCT05630040 | Vagus Nerve Simulation for Long-COVID-19 | COMPLETED | nan | Icahn School of Medicine at Mount Sinai | Composite Dysautonomia Symptom Score (COMPASS 31); Composite Dysautonomia Symptom Score (COMPASS 31); Composite Dysautonomia Symptom Score (COMPASS 31); Composite Dysautonomia Symptom Score (COMPASS 31); Composite Dysautonomia Symptom Score (COMPASS 31) | Fatigue Severity Scale (FSS); Fatigue Severity Scale (FSS); Fatigue Severity Scale (FSS); Fatigue Severity Scale (FSS); Fatigue Severity Scale (FSS); Neuro Quality of Life Score; Neuro Quality of Life Score; Neuro Quality of Life Score; Neuro Quality of Life S |
| NCT06073002 | Effects of a Home-Based Exercise Intervention on Physical Function, Symptoms and Health-Related Quality of Life in Subjects with Long Covid | ACTIVE_NOT_RECRUITING | nan | University of Vienna | Change of peak oxygen consumption (VO2peak measured in ml/min/kg) | Change of maximum lower body isometric muscle strength (measured in N); Change of maximum hand grip strength (measured in kg); Change of Standard Deviation of RR-Intervals (SDNN measured in ms); Change of Root Mean Square of Successive Differences (RMSSD measu |
| NCT07359482 | sElective Serotonin reuPtake inhibitoRs In posT-covid: ESPRIT | NOT_YET_RECRUITING | PHASE3 | Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) | Fatigue severity | Fatigue severity; Cognitive functioning; Cognitive functioning; PEM; POTS (National Aeronautics and Space Administration (NASA) lean test; POTS; Health-related Quality of Life; Disability; Side effects; Side effects; Brain Perfusion (optional MRI substudy); Br |
| NCT05363514 | A Pilot Study of Low Dose Naltrexone Use in Patients With Postural Orthostatic Tachycardia Syndrome | NOT_YET_RECRUITING | PHASE4 | University of Calgary | Fatigue Visual Analogue Scale (VAS) | RAND 36 Health Related Quality of Life Score; Cytokines |
| NCT06511050 | Investigating the Effects of Lumbrokinase in Adults With Long Covid, Post-treatment Lyme Disease Syndrome, and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome | RECRUITING | PHASE1; PHASE2 | Icahn School of Medicine at Mount Sinai | EuroQol Visual Analogue Scale Score (EQ-VAS) | The EuroQol Five-Dimensional Health Questionnaire (EQ-5D-5L); 10-Meter Walk Test; Root mean square of successive differences between normal heartbeats (RMSSD); BrainCheck Cognitive Assessment Battery; General Symptom Questionnaire (GSQ-30); Medical Research Co |
| NCT06978582 | Effectiveness and Safety of a Tele-rehabilitation Program Based on Mindful and Conscious Movement-based Exercise vs Conventional Low-intensity Exercise on Fatigue and Related Varia | ACTIVE_NOT_RECRUITING | nan | University of Seville | Fatigue | Heart Rate Variability; Perceived pain; Perceived Quality of life; Physical function; Interoceptive awareness; Anxiety and depression levels; Perceived sleep quality; Fear of movement; Somatic vigilance; Treatment feasibility |
| NCT05813873 | The Use of Incentive Spirometry (Triflow) in Patients With Long Covid | ACTIVE_NOT_RECRUITING | nan | European University Cyprus | Barthel Index; Barthel Index; Dyspnoea (Medical Research Council Dyspnoea Scale); Dyspnoea (Medical Research Council Dyspnoea Scale); Peak Flow Meter; Peak Flow Meter | Number of hospitalisation days; Muscle strength (Hand Grip); Muscle strength (Hand Grip); Muscle strength and endurance (30 seconds Sit to stand); Muscle strength and endurance (30 seconds Sit to stand); Balance (Berg Balance); Balance (Berg Balance); Cardiore |
| NCT ID | Title | Status | Phase | Sponsor | Primary endpoint | Secondary endpoint |
|---|---|---|---|---|---|---|
| NCT06208696 | Pilot Study to Evaluate the Role of an Evidenced-based Chronic-disease Self-management Program to Support Challenges Experiencing Patients Living With Long-COVID and Chronic Diseas | COMPLETED | nan | University of Puerto Rico | Assessment of the Impact of Health-related Quality of Life; Assessment of the Fatigue in the Impact of the Health-related Quality of Life; Assessment of the Anxiety in the Impact of Health-related Quality of Life | Chronic Diseases Self-management; Auto-efficacy for Disease Management |
| NCT05199233 | The Benefit of Mindfulness-Based Intervention Using A Wearable Wellness Brain Sensing Device (Muse-S™) in the Treatment of Post-Covid Symptoms | COMPLETED | nan | Mayo Clinic | Change in Stress; Change in Anxiety | nan |
| NCT05638620 | Evaluating the Effectiveness of Dual Sympathetic Blocks for Patients Experiencing Sympathetically-Mediated Symptoms From Post-Acute Sequelae of SARS-CoV-2 (PASC) | COMPLETED | PHASE1 | Jonathann Kuo, MD | Patient-Reported Outcomes: PROMIS-29 Score; Depression; Anxiety; Physical function; Pain interference; Fatigue; Sleep disturbance; Ability to participate in social roles and activities status | Autonomic Symptoms: COMPASS-31 Score |
| NCT05848401 | Biosound Therapy as a Treatment for Long COVID Patients: A Randomized Pilot Trial | COMPLETED | nan | Anxiety Relief Center | The Patient Health Questionnaire (PHQ-9); Generalized Anxiety Disorder 7-item scale (GAD-7); Cambridge Brain Sciences (CBS) tasks; COVID-19 Persistent Symptom Questionnaire. | Recruitment Rate; Retention Rate; Open-ended questions to participants about their experience |
| NCT06393790 | Health Effects of a Strength Training Protocol in Women With Fibromyalgia and Healthy Individuals. | COMPLETED | nan | Catholic University of Murcia | PRE-TEST Time up and go test (TUG test); PRE-TEST 5 Times Sit to stand test (5TSTS); PRE TEST 10 meters walk test; PRE TEST 2 minutes walk; PRE TEST Upper body dinamometry; PRE TEST Lower body dinamometry; PRE TEST Sleep assessment: Karolinska Sleepiness Diary | ACUTE PRE-TEST Time up and go test (TUG test); ACUTE POST-TEST Time up and go test (TUG test); ACUTE PRE-TEST 5 Times Sit to stand test (5TSTS); ACUTE POST-TEST 5 Times Sit to stand test (5TSTS); ACUTE PRE TEST 10 meters walk test; ACUTE POST TEST 10 meters wa |
| NCT06726772 | Post-COVID-19 Symptom Burden: Effects of an Outpatient Group Psychotherapy in Long COVID Patients | COMPLETED | nan | Cantonal Hospital of St. Gallen | Change of Fatigue Score measured with the Questionnaire "FSS" (Fatigue Severity Scale) from baseline to 8 weeks; Change of Insomnia Score measured with the Questionnaire "ISI" (Insomnia Severity Index) from baseline to 8 weeks; Change of Qu | nan |
| NCT07190105 | Impact of Vagal Approaches on Symptomatology in Long COVID Participants | COMPLETED | nan | Leidos Life Sciences | Patient Health Questionnaire-8 (PHQ-8); Generalized Anxiety Disorder-7 (GAD-7); PTSD Checklist for DSM-5 Short Form (Abbreviated PCL-5); Symptom Burden Questionnaire - Long COVID (SBQ-LC); Body Perception Questionnaire (BPQ); Benefits Scale; Sleep Metrics; Res | nan |
| NCT05126511 | Effects of Cranial Electrotherapy Stimulation on Anxiety of Patients After COVID-19 - a Randomised Controlled Pilot Study | COMPLETED | nan | Schön Klinik Berchtesgadener Land | Change of symptoms of anxiety during intervention | Change in insomnia during intervention; Change in fatigue during intervention; Change in depression during intervention; Change of general condition/ perceived well-being of the patient; Subjective effectiveness of device; Comfort while using the device |
| NCT05435456 | Effect of Strengthening and Relaxation Exercises on Musculoskeletal Pain, Anxiety, and Sleep Quality on Post-covid Symptoms | COMPLETED | nan | Halic University | McGill Pain Scale short form (SFMPQ); Short-Form 36 (SF-36); Pittsburg Sleep Quality Index; Beck Anxiety Scale | nan |
| NCT05531019 | COVID-19 Sequelae: Treatment and Monitoring of Persistent Symptoms, a Decentralized Approach Focus on the Patient. Use of Dietary Supplement Based on Sea Urchin Eggs With Echinochr | COMPLETED | nan | Fernando Saldarini | Change of symptoms over time-points (baseline, 4 weeks, 8 weeks, 12 weeks) during rutine medical checkup.; Change of lung capacity over four times (baseline, 4 weeks, 8 weeks, 12 weeks) assessed during spirometry.; Change of walking distance during a six minut | Change of Von Willebrand Factor over time-points (baseline, 4 weeks, 12 weeks, 12 weeks) via blood sample.; Change of D Dimer over time-points (baseline, 4 weeks, 12 weeks, 12 weeks) via blood sample.; Change of HS-CRP over time-points (baseline, 4 weeks, 8 we |
| NCT05538650 | Mindfulness-based Social Work and Self-care Study: A Randomised Controlled Trial | COMPLETED | nan | Queen's University, Belfast | Change in Stress measured on the Perceived Stress Scale (PSS); Change in Burnout measured on the Maslach Burnout Inventory (MBI); Change in Anxiety measured on the Hospital Anxiety and Depression Scale (HADS-A); Change in Depression measured on the Hospital An | Change in Mindfulness measured by on the Southampton Mindfulness Questionnaire (SMQ); Change in Self-compassion measured by on the Self-Compassion Scale (SCS); Change in Worry measured on the Penn State Worry Questionnaire (PSWQ); Change in Attention Regulatio |
| NCT05793736 | A Feasibility Study of an HVR Protocol Biofeedback Training to Manage Long Covid Syndrome Symptoms | COMPLETED | nan | University of Cagliari | Change from Baseline to 5 weeks and to 9 weeks in Patient Health Questionnaire-9 (PHQ-9) score; Change from Baseline to 5 weeks and to 9 weeks in Brief Fatigue Inventory (BFI) score; Change from Baseline to 5 weeks and to 9 weeks in Short Form Health Survey (S | nan |
| NCT06251011 | Effects of Physiotherapy Via Telerehabilitation on Cardiopulmonary, Physical, and Psychological Functions in Patients With COVID-19: A Randomized Controlled Trial | COMPLETED | nan | Chulabhorn Hospital | Cardiopulmonary function; Patient's quality of life; Functional capacity; Anxiety and depression; Insomnia; Cognitive function; Muscle strength | nan |
| NCT06492577 | Effectiveness of Combined Pulmonary Rehabilitation and Progressive Muscle Relaxation on Long-term COVID-19 Symptoms: a Randomized Controlled Trial | COMPLETED | nan | Spitalul Clinic de Boli Infecțioase și Pneumoftiziologie Dr. Victor Babeș Timișoara | Lung function; Exercise capacity; Anxiety; Depression; Sleep Quality; Psychological Well-being | nan |
| NCT05630339 | Efficacy and Security of the Magnesium and Vitamin D Combination as Adjuvant Treatment of Post-COVID Syndrome. A Randomised Double-blind Clinical Trial | COMPLETED | nan | Coordinación de Investigación en Salud, Mexico | Change from Baseline Post-COVID syndrome symptoms at 4 months; Change from Baseline Post-COVID Functional Status at 4 months; Change from Baseline Serum vitamin D levels at 4 months; Change from Baseline Serum Magnesium levels at 4 months; Change from Baseline | Change from Baseline Fasting Blood Glucose levels at 4 months; Change from Baseline Serum Lipid Profile at 4 months; Change from Baseline Serum Calcium levels at 4 months; Change from Baseline Serum Creatinine levels at 4 months |
| NCT06601920 | A Study of Activity Leader to Forest Therapy Campaign in Different Environments Targets on the Participants Which Had Been Infected by SARS-COV-2 | COMPLETED | nan | Taipei City Hospital | Profile of Mood States 2nd Edition-Adult Short, POMS; The Beck Anxiety Inventory, BAI; The Beck Depression In- ventory-Second edition, BDI-II; The brief World Health Organization Quality of Life, WHOQOL-BREF; Fear of COVID-19 Scale, FCV-19S; Salivary Amylase E | Post-COVID Functional Status, PCFS; Blood pressure, Heart rate, and Heart rate variability |
| NCT06379737 | Valutazione Degli Esiti a Medio-lungo Termine Della Sindrome Long Covid in Pazienti Trattati Con un Protocollo di Riabilitazione in Ambiente Termale o in Teleriabilitazione | COMPLETED | nan | Padua University General Hospital | Numerical Rating Scale (NRS); Hand grip strength; Barthel Dyspnea Scale; Fatigue Assessment Scale; Beck's Depression Inventory (BDI; Beck Anxiety Inventory (BAI); 12-Item Short Form Health Survey (SF-12) | Patients satisfaction |
| NCT06928480 | Effectiveness and Acceptability of the Unified Protocol for the Transdiagnostic Treatment of Emotional Disorders in People With Long COVID-19. | RECRUITING | nan | Instituto de Investigación Sanitaria Aragón | General Depression Severity and Interference Scale (ODSIS; Bentley et al., 2014. Validated in Spanish by Osma et al., 2019); General Severity and Interference Scale for Anxiety (OASIS; Norman et al., 2006. Validated in Spanish by Osma et al., 2019) | Memory Failures of Everyday, MFE (Sunderland et al., 1983; Montejo et al., 2014); Multidimensional Inventory for Emotional Disorders (MEDI; Rosellini and Brown, 2019. Validated in Spanish by Osma et al., 2023); Emotional Regulation Difficulties Scale (DERS; Gr |
| NCT07197138 | Pilot Study on the Effects of Intensified Repetitive Transcranial Magnetic Stimulation on Immunological Blood Parameters in Patients With Depression and Comorbid Post-COVID-19 Cond | RECRUITING | nan | Max-Planck-Institute of Psychiatry | Change in immunophenotypic marker CRP from baseline to post-treatment; Change in immunophenotypic marker TNF from baseline to post-treatment; Change in immunophenotypic marker IL-1ß from baseline to post-treatment; Change in immunophenotypic marker IL-6 from b | Change in Fatigue Severity Scale (FSS, self-rating); Change in Fatigue Scale for Motor and Cognitive Functions (FSMC, self-rating); Change in Post-Exertional Malaise (PEM) Questionnaire (self-rating); Change in Pittsburgh Sleep Quality Index (PSQI, self-rating |
| NCT06716996 | Repeated Transcranial Magnetic Stimulation for the Treatment of Post-COVID Associated Affective Symptoms | RECRUITING | nan | Flurin Cathomas | Depression severity | Individual symptom dimensions and levels of functioning/quality of life.; Immune markers |
| NCT06522750 | Pilot Study on the Feasibility of an RCT: Evaluating Periodic Fasting as a Treatment Strategy for Long Covid in Adults | RECRUITING | nan | University of Luxembourg | Nutritional protocol; Fatigue assessment Scale (FAS); Quality of Life (WHOQOL); Functionality (WHODAS 2.0); Anxiety (GAD-7); Depression (PHQ-9); Mood States; Blood preasure | Urine Metabolomics; Gut Microbiome; Stool Metabolomics; Blood cytokines; Blood Mitochondrial dysfunction; Blood Epigenetics; Blood test |
| NCT06897553 | Acceptance and Commitment Therapy- Based Group Therapy for Mental Health in Neurological Disorders | RECRUITING | nan | Bielefeld University | Depression and Anxiety Stress Scales-21 (Lovibond, 1995); Acceptance and Action Questionnaire-Acquired Brain Injury (Sylvester, 2011); Wechsler Adult Intelligence Scale - Fourth Edition (Similarities subtest; Wechsler, 2008) | Patient Health Questionnaire-9 (Kroenke, 2001); Generalized Anxiety Disorder Scale-7 (GAD-7; Spitzer et al., 2007); Valuing Questionnaire (Smout, 2014); Self-as-context scale (Zettle, 2018); World Health Organization Disability Assessment Schedule 2.0 (V.S. Üs |
| NCT05268523 | Interventions to Teach Self-management Skills for Persisting Symptoms of COVID-19: Minimizing Impact of Symptoms on Everyday Functioning and on Healthcare Usage/utilization | RECRUITING | nan | Toronto Rehabilitation Institute | Change in Brief-COPE; Change in LOT; Change in Kessler Psychological Distress Scale (K10); Change in SSS-8; Change in Perceived Medical Condition Self-Management Scale; Change in the Depression, Anxiety and Stress Scale; Change in Quality of Life Enjoyment and | Feasibility: session feedback questionnaire; Feasibility: Recruitment rate; Feasibility: Retention rate; Feasibility: Adherence rate; Feasibility: qualitative interview |
| NCT06510985 | Transcutaneous Vagus Nerve Stimulation (tVNS) for Improved Recovery After Exertion in Patients With Long/Post-COVID. | NOT_YET_RECRUITING | nan | University Hospital Tuebingen | Stimulation-induced changes in invigoration: frequency of button presses during the first seconds of the trial to gain monetary rewards in the Effort Allocation Task.; Stimulation-induced changes in symptoms of depression; Stimulation-induced changes in physic | Stimulation-induced changes in heart rate variability; Stimulation-induced changes in physical activity; Stimulation-induced changes in wanting the monetary rewards; Stimulation-induced changes in exertion; Stimulation-induced changes in the motivation to inve |
| NCT06074848 | Transcranial Direct Current Stimulation as a Strategy for the Management of Disorders Generated by COVID-19: a Multicentric Study. | UNKNOWN | PHASE2 | Universidade Federal de Pernambuco | Fatigue - Modified Fatigue Impact Scale (MFIS); Pain measure - Brief Pain Inventory (BPI); Pain measure - Visual Analog Scale (VAS); Cognitive deficit - Montreal Cognitive Assessment Instrument (MoCA); Cognitive deficit - FAS Test; Cognitive deficit - CFL Test | COVID clinical situation; Level of physical activity; State of strength and effort; Exercise capacity - 6-minute walk test; Immunometabolic evaluation |
| NCT05981872 | EFFECT OF COGNITIVE BEHAVIORAL THERAPY ON DEPRESSION AND QUALITY OF LIFE IN PATIENTS WITH POST COVID-19 | UNKNOWN | nan | Cairo University | The Mini- Mental State Examination (MMSE); Beck depression inventory (BDI); .Katz Index of Independence in Activities of Daily Living | nan |
| NCT05581277 | Efficacy of the Unified Protocol for Transdiagnostic Treatment of Emotional Disorders (UP) in People With Post Covid-19 Condition and Emotional Symptomatology. | UNKNOWN | nan | Instituto de Investigación Sanitaria Aragón | Sociodemographic data; Table of symptoms referred by the patient; Overall Anxiety Severity and Impairment Scale (OASIS); Overall Depression Severity and Impairment Scale (ODSIS); Anxiety and related disorders interview (ADIS-5); Adjustment disorders | The Multidimensional Emotional Disorder Inventory (MEDI); Health-related quality of life (EuroQol-5D); Difficulties in Emotion Regulation Scale (DERS); Distress Tolerance Scale (DTS); Adaptation of Client Satisfaction Questionnaire [CSQ-8]; Evaluation question |
| NCT04678700 | Implementation of a Respiratory Physiotherapy Program in Post COVID-19 Patients Through Tele-assistance | UNKNOWN | nan | European University of Madrid | Euroqol-5d european quality of life-5 dimensions; Euroqol-5d european quality of life-5 dimensions; Dysnea scale Borg; Dysnea scale Borg; Respiratory rate; Respiratory rate; Effort dysnea Scale; Effort dysnea Scale; Anxiety; Anxiety; Level oxigen %; Level oxig | nan |
| NCT05890508 | Electro-acupuncture for Long Covid Neuropsychiatric Symptoms: a Prospective, Randomized Sham-controlled, Double-blinded Clinical Trial | UNKNOWN | nan | Hong Kong Baptist University | Cognitive score on the Chinese version of the Mini-Mental State Examination (MMSE) scale; Depression on the Chinese Beck Depression Inventory (CBDI) | Score of Insomnia Severity Index (ISI); Score of Brief Fatigue Inventory-Taiwanese (BFI-T) Form; Score of the Short Form 12 (SF12) |
| NCT05951803 | Effectiveness of the Brief Behavioral Intervention for Insomnia in the Teleconsultation Modality (ICBI-TC) on the Symptoms of Anxiety, Depression, Sleep Quality and Quality of Life | UNKNOWN | nan | Hospital General de Mexico | Sleep diary; Patient Health Questionnaire 9 (PHQ-9); Pittsburgh Sleep Quality Index (PSQI); Insomnia Severity Index (ISI); SF-36 Health Survey; Generalized Anxiety Disorder 7 (GAD-7) | Sleep diary; Patient Health Questionnaire 9 (PHQ-9); Pittsburgh Sleep Quality Index (PSQI); Insomnia Severity Index (ISI); SF-36 Health Survey; Generalized Anxiety Disorder 7 (GAD-7); Sleep diary; Patient Health Questionnaire 9 (PHQ-9); Pittsburgh Sleep Qualit |
| NCT05753228 | In Vivo Investigation on Mitochondrial Dysfunction in Post-COVID Fatigue and Cancer Fatigue. | UNKNOWN | nan | National University Hospital, Singapore | MRI, 3D Arterial Spin Labelling (ASL) and 1H magnetic resonance spectroscopy (MRS); Chalder Fatigue Scale; Health Questionnaire (EQ-5D-5L); Hamilton Depression Rating Scale | nan |
| NCT05000255 | Coping With Covid-19: Loneliness, Self-Efficacy, Social Support and Depression and Anxiety in Patients in Medical Rehabilitation. A Field Study in Geriatrics and Physical Medicine | UNKNOWN | nan | Annette Reichardt, MD | Measurement with the UCLA Loneliness Scale; Measurement with the Hospital Anxiety and Depression Scale (HADS) | Measurements with the General Self-Efficacy Expectancy Scale (GSE); Measurements of Stage-specific Self-Efficacy, German Version, by Lippke, S.; Measurements of Activities against loneliness, German Version, by Lippke, S.; Measurements of Perceived Social Supp |
| NCT06348212 | Effect of Probiotic Strain Lactobacillus Paracasei PS23 on Brain Fog in People With Long COVID | UNKNOWN | nan | Taipei Veterans General Hospital, Taiwan | Long covid related symptoms; Hospital Anxiety and Depression Scale; The Pittsburgh sleep quality index; Fatigue Severity Scale; GI symptoms; Cognitive function-Digit symbol substitution test; Cognitive function-The Montreal Cognitive Assessment(MoCA); Cognitiv | nan |
| NCT ID | Title | Status | Phase | Sponsor | Primary endpoint | Secondary endpoint |
|---|---|---|---|---|---|---|
| NCT05104749 | Homeopathic Treatment of Post-acute COVID-19 Syndrome- A Pilot Randomized Controlled Trial | COMPLETED | PHASE3 | Southwest College of Naturopathic Medicine | Fatigue Assessment Scale (FAS); SF-36 Physical Composite Score (PCS); SF-36 Mental Composite Score (MCS) | Patient Health Questionnaire-9 (PHQ-9); Measure Yourself Medical Outcomes Profile Symptom #1; Measure Yourself Medical Outcomes Profile Symptom #2; Patient Doctor Depth of Relationship (PDDR) |
| NCT05074888 | A Multicenter, Double-blind, Placebo-controlled, Parallel-group, Randomized Clinical Trial of Efficacy and Safety of Prospekta in the Treatment of Patients With Post-COVID-19 Asthe | COMPLETED | PHASE3 | Materia Medica Holding | Change in the Mean FSS Score. | Change in Distance of the 6-minute Walk Test.; Change in the Severity of Anxiety on the HADS Subscale.; Change in the Severity of Depression on the HADS Subscale.; Change in the Mean FSS Score Within Follow-up Period.; Change in Distance of the 6-minute Walk T |
| NCT05618587 | Effect of Low-dose Lithium Therapy on Long COVID Symptoms: a Randomized Controlled Trial. | COMPLETED | PHASE2 | State University of New York at Buffalo | Fatigue Severity Scale; Brain Fog Severity Scale | Patient Global Impression of Change (PGIC); Well-Being Scale; Short Form-12 Health Survey (1-week Modification); Desire to Continue Therapy; Generalized Anxiety Disorder-2 Scale; Headache and Body Pain Bother Scale; Insomnia Severity Index; Sense of Smell and |
| NCT04141696 | A Proof-of-Concept Trial on the Effect of Ketamine on Fatigue | COMPLETED | PHASE1; PHASE2 | National Institute of Nursing Research (NINR) | Percentage Change in Self-reported Fatigue Visual Analog Scale (VAS) Scale | Percentage Change in Self-reported Fatigue Visual Analog Scale (VAS) Scale - Day 7; Areas Under the Curve (AUC) for Percentage Changes in Self-reported Fatigue VAS Score - Through Day 7; Mean Physical Activity Count Using Actigraphy; Fatigue Level Measured by |
| NCT06253806 | Stellate Ganglion Block for the Treatment of COVID-19-Induced Parosmia: Double-Blinded, Placebo-Controlled Randomized Clinical Trial | COMPLETED | PHASE2 | Washington University School of Medicine | Parosmia Olfactory Dysfunction Outcomes Rating | Clinical Global Impression - Severity Scale (CGI-S) Smell Loss; Long-COVID Questionnaire; Olfaction Catastrophizing Scale (OCS); Hospital Anxiety and Depression Scale (HADS); Patient Satisfaction With Treatment; Assessment of the Blind |
| NCT05126563 | A Randomized, Double-blinded, Single-center, Phase 2 Efficacy, and Safety Study of Allogeneic HB-adMSCs for the Treatment of Patients With Chronic Post-COVID-19 Syndrome. | COMPLETED | PHASE2 | Hope Biosciences Research Foundation | Changes From Baseline in Visual Analog Scale of Neurological Symptoms. - Extreme Fatigue (ANCOVA Model); Changes From Baseline in Visual Analog Scale of Neurological Symptoms.. - Brain Fog (ANCOVA Model); Changes From Baseline in Visual Analog Scale of Neurolo | Changes From Baseline in Visual Analog Scale of Non-Neurological Symptoms. - Dyspnea at Rest (ANCOVA Model); Changes From Baseline in Visual Analog Scale of Non-Neurological Symptoms. - Dyspnea During Activity (ANCOVA Model); Changes From Baseline in Visual An |
| NCT06268288 | Pilot Study--The Effects of Non-invasive Vagal Neurostimulation (nVNS) in Adolescents With Postural Orthostatic Tachycardia Syndrome (POTS) | COMPLETED | nan | Mayo Clinic | The Change in Composite Autonomic Symptom Score (COMPASS-31); The Change in Child Functional Disability Inventory Scores; The Change in Heart Rate (Beats Per Minute) in Head up Tilt Table Tests | Change in the Number of Headaches Experienced by Adolescent Patients With POTS; Change in Exercise Duration (Minutes) in Adolescent Patients With POTS; Change in PHQ-9 Scores in Adolescent Patients With POTS |
| NCT05453201 | Developing an Integrative, Recovery-Based, Post-Acute COVID-19 Syndrome (PACS) Psychotherapeutic Intervention | COMPLETED | nan | VA Office of Research and Development | Change in Functional Improvement Post-COVID-19 Over Time | Change in Health-Related Functional Status Over Time; Change in Suicide Risk Over Time; Change in Self-perceived Status on Several Skills Over Time; Change in Identity Concerns Over Time; Change in Depression Over Time; Change in Anxiety Over Time; Change in Q |
| NCT04938687 | Pilot, Effect of Respiratory-Gated Auricular Vagal Afferent Nerve Stimulation (RAVANS) on Post-Treatment Lyme Disease Syndrome | COMPLETED | nan | Spaulding Rehabilitation Hospital | Horowitz Lyme-Multiple Systemic Infectious Disease Syndrome Questionnaire | Sedentary Behaviors Questionnaire; Fatigue Symptom Inventory; Brief Pain Inventory-Pain 24 Hours; Beck Depression Inventory; Beck Anxiety Inventory; Pittsburgh Sleep Quality Index; Timed Up and Go; Time to Complete 4 Meters at Usual Walking Speed,; NIH Toolbox |
| NCT05597722 | Randomized Study to Evaluate Strategies to Address Cognitive Fog in Long-COVID-19 Patients | TERMINATED | PHASE4 | Eva Szigethy | Change in Cognitive Impairment - MOCA; Change in Cognitive Impairment - BrainCheck; Change in Cognitive Impairment - ImPACT | Change in Depression - PHQ8; Change in Quality of Life - SWLS; Change in Disability |
| NCT05513560 | REcovering From COVID-19 Lingering Symptoms Adaptive Integrative Medicine (RECLAIM) | COMPLETED | PHASE2; PHASE3 | University Health Network, Toronto | SF-36 physical component score (PCS) | Symptoms scale; Symptom Checklist; Six Minute Walking Test (6MWT) with oximetry; TestMyBrain cognitive testing; Post COVID19 functional status scale; Reintegration to Normal Living Index (RNLI); Fatigue Scale; Brief Fatigue inventory; Post-Exertional Malaise; |
| NCT04795557 | Effect of ADAPT232 Supplementation on Recovery of Patients in Rehabilitation Period in Long COVID-19: a Randomized, Double-blind, Placebo-controlled Trial | COMPLETED | PHASE2; PHASE3 | Swedish Herbal Institute AB | Duration of symptoms of Long COVID:; Number of participants clinically recovered; Length of home stay/ sick listed; Severity of the Long COVID symptoms | Hypercoagulation marker; Immune response marker; Inflammatory marker; Physical activity; Cognitive performance score; Severity of anxiety and depression; Severity of anxiety |
| NCT05890534 | Pycnogenol® in People With Post-COVID-19 Condition: a Quadruple-blind, Randomized, Placebo-controlled Trial | COMPLETED | PHASE3 | University of Zurich | Health status (EQ-VAS) | Post COVID-19 symptoms; Fatigue; Dyspnea; Cognitive function; Anxiety and depression; Health-related quality of life (EQ-5D-5L); Functional exercise capacity; Physical activity; Soluble Thrombomodulin (sTM); von Willebrand Factor antigen (VWF:Ag); Syndecan-1; |
| NCT04997395 | Safety and Tolerability of Full Spectrum Cannabidiol Dominant Medicinal Cannabis in Treating Symptoms Associated With Long COVID: A Feasibility Study | COMPLETED | PHASE2 | Bod Australia | Recruitment rate; Tolerability for the treatment of long COVID; Number of side effects | Long COVID symptoms; Fatigue; Self-reported quality of life; Pain score; Mood (anxiety); Mood (depression); Sleep quality; Resting heart rate (expressed as average beats per minute); Activity levels (number of daily steps, distance walked, stairs climbed, acti |
| NCT04961190 | A Comparison of Prolonged Exposure Therapy, Pharmacotherapy, and Their Combination for PTSD: What Works Best, and for Whom | ACTIVE_NOT_RECRUITING | PHASE4 | University of Pennsylvania | Change during active treatment on the Clinician-Administered PTSD Scale for DSM-5 (CAPS-5); Change during follow-up on the Clinician-Administered PTSD Scale for DSM-5 (CAPS-5); Change during active treatment on the PTSD Checklist for DSM-5 (PCL-5); Change duri | Change during active treatment on the Quick Inventory of Depressive Symptoms - clinician rated (QIDS-C); Change during follow-up on the Quick Inventory of Depressive Symptoms - clinician rated (QIDS-C); Change during active treatment on the Patient Health Ques |
| NCT05228899 | A Phase I/II Multicenter, Randomized, Double Blinded, Placebo Trial to Evaluate the Safety and Potential Efficacy of Zofin Infused Intravenous (IV) in Patients Experiencing Prolong | COMPLETED | PHASE1; PHASE2 | ZEO ScientifiX, Inc. | Incidence of Severe Adverse Events | Fatigue Severity Score Score; Daily Diary of COVID-19 Related Symptom; COVID-19 Associated Symptoms Length; COVID-19 Associated Symptoms Mitigation; Beck Depression Inventory Score; Mental Fatigue Questionnaire Score; Pulse Oxygen Saturation; Heart Rate Variab |
| NCT05497089 | Temelimab as a Disease Modifying Therapy in Patients With Neurological, Neuropsychological, and Psychiatric (=Neuropsychiatric) Symptoms in Post-COVID 19 or Postacute Sequelae of C | COMPLETED | PHASE2 | GeNeuro SA | Improvement in fatigue in PASC patients | Fatigue; Cognitive function; Cognitive function; Cognitive function; Cognitive function; Anxiety; Depression; Overall quality of Life; Functional impairment; Post-COVID-19 Functional Status; Safety and tolerability of Temelimab in PASC patients |
| NCT06223971 | A Phase l Study to Assess the Safety and Tolerability of PET Imaging With [11 C]CPPC [5-cyano-N-( 4-( 4-[l l CJ me1hylpiperazin-l-yl)-2-(Piperidin-l-yl)Phenyl)Furan-2-carboxamide] | COMPLETED | EARLY_PHASE1 | Johns Hopkins University | To assess the safety and tolerability of one dose level of [11C]CPPC when administered intravenously.; Safety of use of [11C]CPPC in patients with Long-COVID and healthy participants with history of COVID-19 infection as assessed by a change in complete blood | Biodistribution of [11C]CPPC by PET imaging; Cognitive function as assessed by the NIH Toolbox Cognition Battery (NIHTB-CB); Neuro-psychological assessment as assessed by the The Rey-Osterrieth complex figure test (ROCF); Global cognitive function as assessed |
| NCT06721949 | Taurine Supplementation as a Novel Therapeutic Approach for Neurocognitive Symptoms in Long COVID | RECRUITING | PHASE2; PHASE3 | University of Alberta | Mean change in Modified Fatigue Impact Scale (MFIS) from baseline to three months; Mean change in the ratio of the Trail-Making Tests A & B in the TestMyBrain cognitive testing battery from baseline to three months. | Core Outcome Set - Symptoms; Cardiovascular function; Respiratory function; Cognitive Function; Memory; Concentration; Conceptual Thinking; Social Functioning; Mental Health Status - PHQ-9; Mental Health Status - GAD-7; Post-Exertional Malaise (PEM) Symptoms; |
| NCT06974058 | Evaluation of a Quercetin/Curcumin-Based Supplement for Mild to Moderate Long COVID-19 Symptoms: A Pragmatic, Interventional Clinical Study. | COMPLETED | nan | Liaquat University of Medical & Health Sciences | Change in Overall Symptom Burden | Change in Functional Status and Quality of Life (SF-36 Scores); Change in the Need for Prescribed Medications or NSAIDs (Non-Steroidal Anti-Inflammatory Drugs); Change in Pain Severity and Pain Interference (Brief Pain Inventory - Short Form); Change in Fatigu |
| NCT05119634 | The Effect of Whole Body Vibration Training in Individuals With Post COVID - 19 | COMPLETED | nan | Istanbul University - Cerrahpasa | 6 minutes walking test; 6 minutes pegboard and ring test; International Physical Activity Form (IPAQ); activity monitoring with Actigraf GT3X; peripheral muscle strength measurement; pulmonary function test | Post-COVID-19 Functional Status Scale; Chalder Fatigue Questionnaire; Clinical Frailty Scale; EuroQol- 5 Dimension; Hospital Anxiety and Depression Scale (HADS); Impact of Events Scale (IES-R); Pittsburgh Sleep Quality Index (PSQI); static posturography device |
| NCT05218174 | Exercise Training and Functional, Cognitive, and Emotional Well-being in Adults with Post-Acute Sequelae of SARS-CoV-2 (COVID-19) Infection (PASC): a Randomized Controlled Trial | COMPLETED | nan | Baylor Research Institute | Peak Oxygen Consumption (VO2max), mL/min; Peak Oxygen Consumption (VO2max), mL/min; Peak Oxygen Consumption (VO2max), mL/min; Score on Cognitive Function Self-Assessment Scale (CFSS); Score on Cognitive Function Self-Assessment Scale (CFSS); Score on Cognitive | Duration, mm:ss; Duration, mm:ss; Duration, mm:ss; Peak VO2 (absolute), mL/min; Peak VO2 (absolute), mL/min; Peak VO2 (absolute), mL/min; Peak VO2 (relative), mL/kg/min; Peak VO2 (relative), mL/kg/min; Peak VO2 (relative), mL/kg/min; Metabolic Equivalents; Met |
| NCT06315894 | Design and Implementation of a Supervised Computerized Active Program (SuperCAP) for Improvement of Cognitive, Emotional, and Functional Status in People With Post-COVID Syndrome. | COMPLETED | nan | Fundación FLS de Lucha Contra el Sida, las Enfermedades Infecciosas y la Promoción de la Salud y la Ciencia | Change in Self-reported Cognitive Functioning | Change in Performance-based Cognitive Functioning; Change in Depression Symptoms; Change in Anxiety Symptoms; Change in Daily Activities Functioning; Change in Physical Activity; Change in Quality of Life |
| NCT06330376 | Diaphragmatic Breathing Exercises for Post-COVID-19 Diaphragmatic Dysfunction (DD) | COMPLETED | nan | University of Minnesota | 6-minute walk test (6MWT) | PHQ9: Patient health questionnaire 9; GAD7: Generalized anxiety disorder 7-item; PROMIS score: Patient-Reported Outcomes Measurement Information System; QoL scale: Quality of life scale; FACIT fatigue scale 's Fatigue score; Modified Borg dyspnea scale; R |
| NCT06419712 | Effect of Vitamin D Supplementation on Glutathione Peroxidase (GPx) Activity, Interleukin-6 (IL-6) Levels and Clinical Outcomes in Post-COVID-19 Patients | COMPLETED | nan | Escuela Militar de Graduados de Sanidad, SEDENA | Glutathione Peroxidase (GPx) Activity; Serum Levels of Interleukin-6 (IL-6) | Lung Function Tests; Neuropsychiatric Symptoms (Anxiety and Depression) |
| NCT05196451 | Short-time Behavioural Intervention in Post-Covid Syndrome (SIPCOV): A Pragmatic Randomised Controlled Trial | COMPLETED | nan | University Hospital, Akershus | Physical Functioning | Fatigue; Fatigue; Depression/anxiety; Depression/anxiety; Adverse effects; Adverse effects; Physical Functioning; Recovery from PIFS; Recovery from PIFS |
| NCT05855369 | A Randomized Controlled Trial of Smell Training and Trigeminal Nerve Stimulation in the Treatment of COVID-related Persistent Smell Loss | RECRUITING | PHASE2; PHASE3 | Medical University of South Carolina | Change in Psychophysical Olfactory Function from Baseline to 4 and 12 Weeks; Change in Perceived Intensity of Odorants from Baseline to 4 and 12 Weeks; Change in Perceived Hedonics of Odorants from Baseline to 4 and 12 Weeks; Change in Olfactory-related Qualit | Change in Long COVID Symptoms from Baseline to 4 and 12 Weeks; Change in Sustained Attention from Baseline to 4 and 12 Weeks; Change in Cognitive Function from Baseline to 4 and 12 Weeks; Change in Mood State from Baseline to 4 and 12 Weeks; Change in Sleep Qu |
| NCT06091293 | Narrative Intervention for Long COVID-19 (NICO) Research Study | COMPLETED | nan | University of Colorado, Denver | Personal Health Questionnarrie- 8 item (PHQ8) | Generalized Anxiety Disorder- 7 item (GAD7) |
| NCT06658340 | Positivity in Post-COVID: Promoting Well-being in Patients with Post-COVID-19 Syndrome - a Feasibility and Acceptability Study | COMPLETED | nan | University of Twente | Feasibility of the intervention exercises; Acceptability of the intervention exercises - willingness to do again; Acceptability of the intervention exercises - satisfaction; Acceptability of the intervention exercises - perceived utility; Acceptability of the | Change in affect; Change in mental well-being; Change in post-COVID symptom severity and functionality; Change in fatigue; Change in anxiety; Change in depression; Change in ability to adapt; Change in perceived illness control; Perceived overall impact |
| NCT05244044 | Changes in Functional Exercise Capacity After PUlmonary REhabilitation in Primary Care: a Randomized, Controlled, Multicenter, Pragmatic Trial in 134 Patients With Long COVID (PuRe | COMPLETED | nan | University Hospital, Antwerp | Exercise capacity | Change in physical activity; Change in COVID-19 related symptoms; Change in quality of life; Change in fatigue; Change in dyspnoea; Change in functional status; Change in work productivity and activity impairment.; Change in anxiety and depression symptoms.; C |
| NCT05630378 | Evaluation of a Multimodal Integrative Medicine and Naturopathy Program in an Outpatient Setting With Focus on Mind-Body Medicine and Mild Water-filtered Infrared-A Whole-body Hype | COMPLETED | nan | Universität Duisburg-Essen | Fatigue - Change from week 0 to week 11 | Quality of life 1; Hospital Anxiety and Depression; Perceived Stress; perceived Pain; Quality of life 2; Sleep Quality; Resilience |
| NCT05373407 | A Randomized Controlled Trial Examining the Impact of Low Versus Moderate-intensity Aerobic Training in Post-discharge COVID-19 Older Subjects | COMPLETED | nan | University of Hail | Distance walked in the 6-min walk test (6 MWT); Post-Covid Functional Scale (PCFS) | Number of repetitions performed in a 1-min Sit-to-Stand (STS) test; 2. Anxiety and Depression evaluated by the HAMLITON ScAnxiety and Depressionale (HADS); Quality of life SF-36 |
| NCT05699538 | Fatigue and Fatigability in Veterans Following SARS-CoV-2 Infection | COMPLETED | nan | VA Office of Research and Development | Performance fatigability | Rating of Perceived Fatigue (RPF); Isometric and Isokinetic Knee Extensor Torque; Skeletal muscle oxygen extraction; Feeling Scale; Fatigue Severity Scale (FSS); Short Physical Performance Battery (SPPB); 30-second sit-to-stand; Six Minute Walk Test (6MWT); Mo |
| NCT05798221 | Complementary Self-help Strategies for Patients With Post-COVID-19 Syndrome: A Randomized Controlled Trial | COMPLETED | nan | Universität Duisburg-Essen | Post-COVID-19 symptom burden | Post-COVID-19 symptom burden; Post-COVID-19 functional status (self-reported); Post-COVID-19 functional status (self-reported); Health-related quality of life; Health-related quality of life; Fatigue; Fatigue; Anxiety and depression; Anxiety and depression; In |
| NCT04841759 | The Effects of a Multi-factorial Rehabilitation Program for Healthcare Workers Suffering From Post-COVID-19 Fatigue Syndrome | COMPLETED | nan | Medical University of Vienna | Change of maximum oxygen uptake (VO2max) over time-points (baseline - 4 weeks - 8 weeks) assessed during cardio-pulmonary exercise testing (CPET) | Change of walking distance during a six minutes walk test (6MWT) over time-points (baseline - 4 weeks - 8 weeks); Change of numbers over time-points (baseline - 4 weeks - 8 weeks) how often someone can stand up and sit down on a chair within 30 seconds during |
| NCT04983394 | Effect of Motion-Controlled Video Games-Based Virtual Reality Exercise On Pain, Fatigue, Mood, Functional Capacity, And Quality of Life in Patients With Post-Covid-19 Condition: A | COMPLETED | nan | Cumhuriyet University | visual Analogue Scale | hospital anxiety and depression scale-Depression; hospital anxiety and depression scale-Anxiety; Fatigue severity scale; Short Form-12; 6 minutes walking test |
| NCT05032885 | RANDOMIZED CLINICAL TRIAL OF PHYSIOTHERAPY IN COVID PATIENTS ON THEIR PHYSICAL CONDITIONING, ANXIETY LEVEL AND THEIR QUALITY OF LIFE | COMPLETED | nan | Hospital Universitario Getafe | Respiratory competence; Motor competence | Anxiety state; Variation in the level of quality of life |
| NCT06054438 | Examining the Immunomodulatory and Health Improving Function of a Chinese Medicine Nutritional Supplement Cs4 on Immunity-related Disorders in the Post-COVID Era | COMPLETED | nan | The University of Hong Kong | the change in symptom severity from 0 to 12 weeks measured by the modified COVID-19 Yorkshire Rehabilitation Scale (C19-YRSm) | the change in Insomnia Severity Index (ISI) from 0 to 12 weeks; the change in Brief Fatigue Inventory Form (BFI) from 0 to 12 weeks; the change in St. George's Respiratory Questionnaire (SGRQ) from 0 to 12 weeks; the change in Hospital Anxiety and Depress |
| NCT05126511 | Effects of Cranial Electrotherapy Stimulation on Anxiety of Patients After COVID-19 - a Randomised Controlled Pilot Study | COMPLETED | nan | Schön Klinik Berchtesgadener Land | Change of symptoms of anxiety during intervention | Change in insomnia during intervention; Change in fatigue during intervention; Change in depression during intervention; Change of general condition/ perceived well-being of the patient; Subjective effectiveness of device; Comfort while using the device |
| NCT06108297 | Effect of Low-dose Lithium Therapy on Long COVID Symptoms: an Open-label, Dose-finding Study. | COMPLETED | PHASE1 | State University of New York at Buffalo | Fatigue Severity Scale (FSS); Brain Fog Severity Scale (BFSS) | Well Being Scale; Short Form-12 Health Survey; FSS scores in those with FSS score ≥28 at baseline; BFSS scores in those with FSS score ≥28 at baseline; Modified Fatigue Impact Scale; Perceived Deficits Questionnaire, 5-Item Version; Beck Depression Inventory-I |
| NCT06341751 | Psychological Treatment for Persistent Fatigue: a Feasibility Study | COMPLETED | nan | Karolinska Institutet | Treatment adherence and completion; Treatment credibility; Patient satisfaction; Working alliance; Negative effects of treatment; Open-ended questions regarding treatment content and presentation | Feasibility of study inclusion procedures and data-collection; Fatigue severity, primary self-rated symptom outcome; Problems concentrating; Reduced physical activity; Reduced motivation; Depressive symptoms; Somatic symptoms; General anxiety; Insomnia; Percei |
| NCT06960928 | Low Dose Sirolimus in People With Post-Acute Sequelae of COVID-19 (PASC) Long COVID-19 | RECRUITING | PHASE3 | Icahn School of Medicine at Mount Sinai | European Quality of Life-Visual Analogue Scale (EQ-VAS) | The EuroQol Five-Dimensional Health Questionnaire (EQ-5D-5L); Patient-Reported Outcomes Measurement Information System 29 (PROMIS-29); General Symptom Questionnaire (GSQ-30); Patient Health Questionnaire (PHQ-9); Generalized Anxiety Disorder (GAD-7); Neuro-QoL |
| NCT06016192 | Medical Rehabilitation of Patients With Long-term Post-Covid-19 Syndrome - a Comparison of Aerobic Interval and Continuous Training | COMPLETED | nan | University of Witten/Herdecke | Change in Cardiorespiratory Fitness (CRF) | Change in Submaximal Cardiorespiratory Fitness (CRF); Change in Fatigue; Work requirements and workload; Change Health-related quality of life; Wellbeing; Change in Depression and Anxiety |
| NCT06928272 | LC-REVITALIZE - A Long Covid Repurposed Drug Study | RECRUITING | PHASE3 | Douglas D. Fraser | Symptom Burden Questionnaire (SBQ) Subscales | General participant reported overall well-being using the Patient Reported Outcome Measurement Information System (PROMIS)-29 questionnaire; General participant reported overall well-being using the Generalized Anxiety Disorder (GAD)-7 questionnaire; General p |
| NCT06723821 | Effectiveness of Noninvasive Neuromodulation in Post-COVID Musculoskeletal Pain in the Short Term: Randomized Clinical Trial | COMPLETED | nan | University of Alcala | Visual Analogue Scale (VAS) | DN4 scale; Pittsburg Sleep Quality Index score; Hospital Anxiety and Depression Scale (HAND); Quality of life SF12 |
| NCT04741841 | Effect of Probiotic Food Supplement "GutMagnific™" in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS), Also Known as Post-viral Fatigue Syndrome, and Comorbid | COMPLETED | nan | ImmuneBiotech Medical Sweden AB | Changes in ME/CFS symptoms | Changes in Irritable Bowel Syndrome (IBS) symptoms; Changes in the gastrointestinal symptoms based on Rome III criteria; Changes in health related quality of life (RAND 36-Item Health Survey); Changes in Hospital Anxiety and Depression Scale (HADS); Changes in |
| NCT05254301 | Faster Functional Performance Recovery After Individualized Nutrition Therapy Combined With a Patient-tailored Physical Rehabilitation Program Versus Standard Physiotherapy in Pati | COMPLETED | nan | Universitair Ziekenhuis Brussel | 1-minute sit-to-stand (1-MSTS) | Multi-dimensional Fatigue Inventor (MFI-20); EuroQol five-dimensional (five-level version) (EQ-5D-5L); Post-COVID-19 Functional Status (PCFS); Hospital Anxiety and Depression Scale (HADS); Work Productivity and Activity Impairment (WPAI) |
| NCT06980636 | Shengmai Liquid for Long COVID Fatigue: a Randomized Placebo-controlled Trial. | RECRUITING | PHASE4 | Beijing University of Chinese Medicine | The degree of improvement in patient fatigue, measured using the Modified Fatigue Impact Scale (MFIS) | Traditional Chinese Medicine Syndrome Score Scale; Improvement in depression, assessed using the 17-item Hamilton Depression Scale; Improvement in anxiety, assessed using the Hamilton Anxiety Scale (HAMA); Improvement in sleep quality, assessed using the Pitts |
| NCT04794036 | Efficacy of an Asynchronous Telerehabilitation Programme in Post-COVID-19 Patients: a Feasibility Study | COMPLETED | nan | Universidad San Jorge | Fatigue Severity Level | Adherence; Engagement; Satisfaction level; Incidents; Maximum Leg Strength Endurance; Maximum Arm Strength Endurance; Submaximum Aerobic Capacity Walking; Post-COVID Functional Status; Depression, Anxiety and Stress; Self-efficacy; Behavior in sport; Perceived |
| NCT04718506 | Rehabilitation for Post-COVID-19 Syndrome Through a Multicomponent, Educational and Supervised Exercise Intervention [RECOVE] | COMPLETED | nan | Universidad de Murcia | Changes in subject clinical status | Changes in cardiovascular fitness: Maximal oxygen consumption (VO2max); Changes in neuromuscular performance during resistance exercise: Barbell Mean Propulsive Velocity (MPV); Changes in balance: center of pressure (COP) sway; Changes in pulmonary function: F |
| NCT05566379 | Effects of a Mindfulness Intervention on Physical and Psychological Well-Being and Quality of Life in Patients With Post Acute Sequelae of SARS-CoV-2 Infection (PASC) Dysautonomia | COMPLETED | nan | University of California, Los Angeles | Change from baseline in the composite autonomic symptom score COMPASS-31 for autonomic symptoms; Change from baseline in Active Stand Test of hemodynamic symptom parameters, exercise tolerance.; Change from baseline of Six Minute Walk in hemodynamic parameters | Change from baseline in mean scores of PSS- Perceived Stress Scale.; Change from baseline in mean scores of GAD7- Generalized Anxiety Disorder; Change from baseline in mean scores of PHQ-8 - Depressive Symptoms; Change from baseline in mean scores of IES-R - e |
| NCT05787340 | Investigation From Biopsychosocial Perspective of Patients With Rheumatic Disease With Covid-19 Who Participated in a Biopsychosocial Exercise Program: A Case Series With 6-Month F | COMPLETED | nan | Kahramanmaras Sutcu Imam University | Qualitative research | Bilişsel Egzersiz Terapi Yaklaşımı-Biopsychosocial Questionnaire (BETY-BQ); Health Assessment Questionnaire (HAQ); Hospital Anxiety and Depression Scale (HADS) |
| NCT05231512 | The Effects of a Music Therapy Respiratory Protocol on Post-Covid Respiratory Symptoms | COMPLETED | nan | Icahn School of Medicine at Mount Sinai | MRC dyspnea score | Self-reported Chronic Respiratory Questionnaire (CRQ-SR); Visual Analog Scale (VAS); Beck Depression Inventory - short form (BDI-SF); General Anxiety Disorder 7-item questionnaire (GAD-7); Hospital Anxiety and Depression Scale (HADS); Coronavirus Anxiety Scale |
| NCT05954325 | Extracorporal Apheresis Hannover Medical School Study in Post COVID-19 Patients | COMPLETED | nan | Hannover Medical School | Chalder Fatigue Scale | Cognitive Function; Post exertional malaise symptoms; Measure of health status; Depression and Anxiety; Autonomic dysfunction; 6-min. walk test; Hand grip strength; Optical coherence tomography angiography; Cranial magnetic resonance imaging and spectroscopy; |
| NCT05381675 | Short Term Outcomes of Tele-Rehabilitation in Patients With Post-Covid Syndrome | COMPLETED | nan | Harran University | Change from the baseline to the 6th week in mMRC (Modified Medical Research Council) Dyspnoea Scale | Change from the baseline to the 6th week in NPRS; Change from the baseline to the 6th week in the 5 times sit to stand test (5XSST); Change from the baseline to the 6th week in the Hospital Anxiety and Depression Scale; Change from the baseline to the 6th week |
| NCT04827992 | Evaluation of Medical Cannabis and Prescription Opioid Taper Support for Reduction of Pain and Opioid Dose in Patients With Chronic Non-Cancer Pain | COMPLETED | nan | Massachusetts General Hospital | Mean Difference in Prescription Monitoring Program verified opioid dose at baseline and week 24; Mean Difference in Pain, Enjoyment, General Activity (PEG) Scale Summed Score over post-baseline to week 24 interval | Mean Difference in Quality of Life Enjoyment and Satisfaction Questionnaire - Short Form Summed Score at weeks 4, 8, 12, 16, 20, 24; Mean Difference in PROMIS-29 Depression Subscale Summed Score at weeks 4, 8, 12, 16, 20, 24; Mean Difference in PROMIS-29 Anxie |
| NCT05172206 | Symptom-based Rehabilitation Compared to Usual Care in Post-COVID - a Randomized Controlled Trial | COMPLETED | nan | Schön Klinik Berchtesgadener Land | Change from baseline Quality of life assessed by Short Form - 12 Questionnaire at week 4 and week 12 | Change from baseline COVID-related symptoms at week 4 and week 12; Change from baseline lung function at week 4 and week 12; Change from baseline blood gas analysis at week 4 and week 12; Change from baseline Cardiac Doppler echocardiography at week 4 and week |
| NCT05035628 | Cardiopulmonary Rehabilitation in Long COVID-19 Patients With Persistent Breathlessness and Fatigue | COMPLETED | nan | Louis Bherer | Change in cardiorespiratory fitness | Change in 6-min walking test performance; Change in Functional mobility; Change in Lower limb muscles strength; Change in Quality-of-life; Change in Anxiety; Change in Anxiety; Change in Sleep quality; Change in functional respiratory capacity; Change in gener |
| NCT05961462 | Effects of Exercise Training on Patients With Long COVID-19, a Single-center, Randomized, Controlled Study | COMPLETED | nan | Guangdong Provincial People's Hospital | Symptom improvement | Peak oxygen uptake; Quality of life measured by 12-Item Short Form Health Survey (SF12); Anxiety measured by Generalized Anxiety Disorder 7-item scale (GAD-7); Depression measured by Patient Health Questionnaire 9-item scale (PHQ-9); Insomnia measured by Insom |
| NCT06631287 | Randomized Double-Blind Placebo-Controlled Trial EValuating Baricitinib on PERSistent NEurologic and Cardiopulmonary Symptoms of Long COVID (REVERSE-LC) | RECRUITING | PHASE3 | Wes Ely | CNS-Vital Signs Global Cognitive Index | Objective neuropsychological function domains of executive function, memory, processing speed, and motor speed including the CNS-Vital Signs subscale tests at 6-months.; Objective neuropsychological function domains of executive function, memory, processing sp |
| NCT05658536 | The COPE Study: Pilot Intervention to Improve Symptom Self-management and Coping in Adults With Post COVID | COMPLETED | nan | University of Washington | Intervention Acceptability; Intervention Appropriateness; Intervention Feasibility | Depressive Symptoms; Anxiety Symptoms; Fatigue; Sleep Disturbance; Perceived Cognitive Difficulties; Self-Efficacy; Psychosocial Functioning; Pain Interference; Impression of Change; Symptoms and Impact of Post-COVID |
| NCT04919031 | Inspiratory Muscle Trainer Impact on Post Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) COVID-19 Hypertensive Patients With Long Term Persistent Symptoms | COMPLETED | nan | Cairo University | maximal inspiratory pressure | sleeping quality scale; Timed stair climbing; 6 minute walk test; modified medical research council (mMRC) scale (0-4); Oxygen saturation; dyspnea borg scale; postural tachycardia syndrome; blood pressure (mmHg); lactate level; fatigue severity scale (0-63); P |
| NCT05677932 | Bright Light Therapy for Post-COVID-19 Fatigue | COMPLETED | nan | Chinese University of Hong Kong | Change of fatigue symptoms | Change of insomnia symptoms; Change of depressive symptoms; Change of anxiety symptoms |
| NCT05894629 | Effects of an Active Coping Program in Patients With Persistent Post-Covid Pain. | COMPLETED | nan | University of Valladolid | Quality of life (QoL) | Pain Intensity; Body Chart; Quantitative sensory tests; Handgrip Strength assessment; 30 sit to stand test; 6 Minute Walking Test (6MWT); Maximal Inspiratory and Expiration Pressure (MIP/MEP); Catastrophism; Anxiety; Depression; Drug consumption.; Fatigue |
| NCT05225220 | Multimodal Investigation of Post COVID-19 in Females: A Pilot Study | COMPLETED | nan | Casa Colina Hospital and Centers for Healthcare | Change in Flanker Inhibitory Control and Attention Test (Flanker) scores; Change in Picture Sequence Memory Test (PSMT) scores; Change in Dimensional Change Card Sort Test (DCCS) scores; Change in Pattern Comparison Processing Speed scores; Change in List Sort | Change in Magnetic Resonance Imaging (MRI); Change in resting state Electroencephalograph (EEG) signals; Change in blood marker levels; Change in BURNS Anxiety Inventory scores; Change in Becks Depression Inventory (BDI) scores; Change in PROMIS Sleep Disturba |
| NCT06492590 | Assessing a Multicomponent Intervention to Improve Quality of Life in Individuals With Long COVID-19 (COVIDL/MIQoL): A Randomized Controlled Trial | COMPLETED | nan | Consorci Sanitari de Terrassa | Improved quality of life | Improve well-being; Decreased anxiety and depression; Increased resilience; Improve physical activity; Decreased fatigue |
| NCT04301609 | Randomized, Comparative, Double-blind, and Placebo-controlled Clinical Trial to Assess the Improvement of Fatigue, Sleep, Anxiety / Depression, Neurovegetatives Alterations and Qua | COMPLETED | nan | Vitae Health Innovation | Perception of fatigue (FIS-40). | Sleep dysfunction (Pittsburg questionnaire); Hospital anxiety-depression scale (HAD); Quality of life (SF-36) |
| NCT04435002 | The Effect of Acupressure on Fatigue in Individuals With Chronic Fatigue Syndrome | COMPLETED | nan | Istanbul Medipol University Hospital | Fatigue Severity Scale | Beck Depression Inventory; Short Form-36 questionnaire |
| NCT05752331 | Feasibility of Personalised Health Behaviour Coaching to Support Symptoms and Activities of Daily Living in Those With Long COVID-19. | COMPLETED | nan | Bournemouth University | Participant recruitment; Participant randomisation; Participant completion; Participant acceptability | Objective physical activity; Exercise capacity; Muscular strength and endurance; Lung Function; Health related quality of life; Breathlessness; Fatigue; Anxiety and Depression; Cognitive impairment |
| NCT05846126 | Digital Rehabilitation With Cognitive Training, Physical Activity and Mindfulness for People With Post-acute COVID-19 Syndrome With Cognitive Impairment. REHABCOVID Project. | COMPLETED | nan | Consorci Sanitari de Terrassa | Differences between groups in scores of global cognition; Differences between groups in scores of selective attention, inhibition, and processing speed; Differences between groups in scores of Visual scanning and processing speed; Differences between groups in | Differences between groups in scores of anxiety; Differences between groups in scores of depression; Differences between groups in scores of Mindfulness levels; Differences between groups in scores of Fatigue; Differences between groups in scores of psychologi |
| NCT05956405 | Retraining of the Amygdala and Insula for the Treatment of Persistent Covid | COMPLETED | nan | Hospital Miguel Servet | Short Form de 36 items (SF-36); Short Form de 36 items (SF-36); Short Form de 36 items (SF-36); Short Form de 36 items (SF-36); Short Form de 36 items (SF-36); Short Form de 36 items (SF-36) | Sociodemographic data Gender, age, marital status, education, occupation, economical level; Sociodemographic data Gender, age, marital status, education, occupation, economical level; Spanish Chronic Pain Grading Scale; Spanish Chronic Pain Grading Scale; Span |
| NCT05298878 | Virtual Physical Rehabilitation for Patients Living with Long COVID | COMPLETED | nan | McGill University Health Centre/Research Institute of the McGill University Health Centre | Change in the basic mobility domain of the Activity Measure for Post-Acute Care (AM-PAC) | Change in lower-body strength; Change in functional mobility; Change in fatigue; Change in dyspnea; Change in health-related quality of life; Change in health state utilities; Change in anxiety and depression; Change in cognitive function; Change in the degree |
| NCT04996212 | Study of the Effectiveness of a Cardiorespiratory Telerehabilitation Program in Persistent COVID-19 Patients. Randomized Clinical Trial. | COMPLETED | nan | University of Valencia | Quality of life (EQ-5D-5L) | Quality of life (EQ-5D-5L) Change from Baseline PostCovid-19 Functional Satatus Scale at five months (PCFSS); Fatigue Assessment Scale (FAS); London Chest Activity of Daily Living Scale (LCADL); Hospital Anxiety and Depression Scale (HADS); Perceived Stress Sc |
| NCT06391489 | Piloting A Telehealth Deliverable Self-Management and Cognitive Training Program (HOBSCOTCH, HOme Based Self-Management and COgnitive Training CHanges Lives) for People With Post A | ACTIVE_NOT_RECRUITING | nan | Dartmouth-Hitchcock Medical Center | Change in overall quality of life as measured by comparing PROMIS-10 Global Health scores pre- and post-HOBSCOTCH-PACS intervention.; Change in subjective cognition as measured by comparing Neuro-QOL Item Bank v2.0 Cognitive Function scores pre- and post-HOBSC | Change in objective cognition as measured by comparing Symbol-Digit Modalities Test scores pre- and post-HOBSCOTCH-PACS intervention.; Change in objective cognition as measured by comparing California Verbal Learning Test-III scores pre- and post-HOBSCOTCH-PAC |
| NCT05705193 | Computerized Cognitive Remediation of Long COVID Symptoms in Older Adults | ACTIVE_NOT_RECRUITING | nan | UConn Health | Treatment Acceptability/Adherence Scale (TAAS); Credibility/Expectancy Questionnaire (CEQ); System Usability Scale (SUS); Feasibility (proportion of subjects who agree to participate in the offered treatment, complete assigned exercises, and complete the entir | Trail Making Test Part B; Montgomery-Asberg Depression Scale (MADRS); World Health Organization Disability Assessment Schedule (WHODAS); Everyday Cognition (ECog); Verbal Fluency; Stroop Color and Word Test; Fatigue Assessment Scale (FAS); California Verbal Le |
| NCT05967052 | Investigation of Pregabalin Therapy and Complex Rehabilitation in Treating Chronic Fatigue Associated With Post-COVID Syndrome | RECRUITING | PHASE2 | National Institute of Geriatrics, Rheumatology and Rehabilitation, Poland | Change in fatigue intensity expressed as a difference in Multidimensional Fatigue Inventory-20 (MFI-20) score; Walking distance as a difference in score from the 6 Minute Walking Test | Change in the level of satisfaction with life expressed in the form of the result of the Satisfaction with Life Scale (Juczyński); Change in the result obtained in the "Beck Depression Inventory (BDIII)" study; Change in the result obtained in the an |
| NCT06511050 | Investigating the Effects of Lumbrokinase in Adults With Long Covid, Post-treatment Lyme Disease Syndrome, and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome | RECRUITING | PHASE1; PHASE2 | Icahn School of Medicine at Mount Sinai | EuroQol Visual Analogue Scale Score (EQ-VAS) | The EuroQol Five-Dimensional Health Questionnaire (EQ-5D-5L); 10-Meter Walk Test; Root mean square of successive differences between normal heartbeats (RMSSD); BrainCheck Cognitive Assessment Battery; General Symptom Questionnaire (GSQ-30); Medical Research Co |
| NCT06978582 | Effectiveness and Safety of a Tele-rehabilitation Program Based on Mindful and Conscious Movement-based Exercise vs Conventional Low-intensity Exercise on Fatigue and Related Varia | ACTIVE_NOT_RECRUITING | nan | University of Seville | Fatigue | Heart Rate Variability; Perceived pain; Perceived Quality of life; Physical function; Interoceptive awareness; Anxiety and depression levels; Perceived sleep quality; Fear of movement; Somatic vigilance; Treatment feasibility |
| NCT05019963 | Enhancing COVID Rehabilitation With Technology (ECORT): An Open-label, Single Site Randomized Controlled Trial Evaluating the Effectiveness of Electronic Case Management for Indivi | ACTIVE_NOT_RECRUITING | nan | University of Ottawa | Change in WHODAS 2.0 score | WHO Post-COVID CRF; PHQ-9; GAD-7; PSQI; PCL-5; EQ-5D-5L; Fatigue Severity Scale; Fatigue Numeric Rating Scale; Pain Numeric Rating Scale; MRC Dyspnoea Scale; WEMWBS; Oral Trail Making Test A and B; Hopkins Verbal Learning Test-Revised (HVLT-R); Digit Span subs |
| NCT05731570 | Cognitive Impairment in Long Covid: PhEnotyping and RehabilitatiOn (CICERO) | ACTIVE_NOT_RECRUITING | nan | University College, London | Change in Goal-attainment | Change in cognitive function; Change in quality of life (EQ-5D-5L); Change in Life Space Questionnaire; Social Functioning (SF-DEM); Change in Instrumental Activities of Daily Living (IADL) Scale; Generalised Anxiety Disorder Assessment (GAD-7); Change in Pati |
| NCT06821087 | Evaluating the Neuromodulatory Effect of Ketamine in Long COVID: A Pilot Study Targeting Fatigue and Neurocognitive Symptoms | ENROLLING_BY_INVITATION | PHASE2 | University of Texas at Austin | PROMIS SF v1.0 - Fatigue 8a; PROMIS SF v2.0 Cognitive Function 4a; BrainCheck Cognitive Battery; Number of participants with treatment-related adverse events as assessed by standardized interview | PROMIS Global 10 v1.2; NASA Task Load Index (NASA-TLX); Patient Health Questionnaire-9 (PHQ-9); Generalized Anxiety Disorder-7 (GAD-7); Depression in Medically Ill 10 Scale (DMI-10); Long COVID Review of Systems; Neuroimaging (MRI) Outcomes; Serum Biomarker An |
| NCT06739720 | A Randomized, Waitlist-controlled Clinical Study on the Efficacy and Safety of Lingzhi-containing Dietary Supplement CP003 on Chronic Fatigue and Post-COVID Fatigue | NOT_YET_RECRUITING | PHASE2; PHASE3 | The University of Hong Kong | Mean difference in Chalder Fatigue Score | Mean difference in Chalder Fatigue Score; Mean difference in 36-Item Short-Form Health Survey; Mean difference in Fatigue Severity Score; mean difference in (PROMIS) Short Form Fatigue 7A survey; Mean difference in hospital anxiety and depression scale; Mean d |
| NCT05676008 | A Study of Positive Emotions With Long COVID (Post-Acute Sequelae of SARS CoV-2 Infection) | ACTIVE_NOT_RECRUITING | nan | University of California, Davis | Well-being | Perceived Stress; Anxiety symptoms; Depressive symptoms; Physical health; Cardiac symptoms; Well-being |
| NCT06511063 | Investigating the Feasibility of Repurposing HIV Antivirals in Adults With Long Covid | RECRUITING | PHASE2 | Icahn School of Medicine at Mount Sinai | EuroQol 5-Dimension 5-Level (EQ-5D-5L) Visual Analogue Scale | The EuroQol Five-Dimensional Health Questionnaire (EQ-5D-5L); Patient-Reported Outcomes Measurement Information System 29 (PROMIS-29); General Symptom Questionnaire (GSQ-30); Patient Health Questionnaire (PHQ-9); Generalized Anxiety Disorder (GAD-7); Neuro-QoL |
| NCT06204458 | Evaluation of the Efficacy of Mild Water-filtered Infrared-A Whole-body Hyperthermia to Improve Symptoms and Quality of Life in Patients With Post-COVID Syndrome (HyPoCo) | ACTIVE_NOT_RECRUITING | nan | Universität Duisburg-Essen | Multidimensionl Fatigue Inventory (MFI-20); Multidimensionl Fatigue Inventory (MFI-20) | Multidimensionl Fatigue Inventory (MFI-20); Brief Pain Inventory (BPI) - Intensity of pain (Numeric Rating Scale, NRS); Brief Pain Inventory (BPI) - Intensity of pain (Numeric Rating Scale, NRS); Brief Pain Inventory (BPI) - Intensity of pain (Numeric Rating S |
| NCT06042751 | Randomized Comparison of a Telemedicine-supported Psychosomatic Intervention, a Physical Activity Intervention and the Combination of Both in Patients With Post-covid19 Syndrom. | ACTIVE_NOT_RECRUITING | nan | Hannover Medical School | Fatigue | Health-related quality of life; Depression and Anxiety; Physical and psychological fatigue severity; Post-exertional malaise; Multidimensional Fatigue Inventory; Disability; Work ability; Illness Perception |
| NCT06968104 | Stimulation of the Transcutaneous Auricular Vagus Nerve for Improvement of Symptoms in Patients With Post-COVID Syndrome and ME/CFS | ACTIVE_NOT_RECRUITING | nan | University of Luxembourg | Fatigue | Patient Health (Quality of life); Patient Health (Ability); Post-Exertional Malaise (PEM); Autonomic Function; Sleep Quality; Sleepiness; Depression and Anxiety; Patients Activity |
| NCT05094622 | Physical Exercise in Patients With Postural Orthostatic Tachycardia Syndrome (POTS) After Covid-19. | ACTIVE_NOT_RECRUITING | nan | Karolinska Institutet | Change in Health-Related Quality of Life (HRQoL); Change in time in upright position and steps per day | Change in walking distance during 6 minute walk test; Change in oxygen saturation during 6 minute walk test; Change in oxygen desaturation during 6 minute walk test; Change in dyspnea during 6 minute walk test; Change in leg fatigue during 6 minute walk test; |
| NCT06231238 | A Randomised Controlled Trial Assessing the Efficacy of Balance Acceptance and Commitment Therapy (ACT) for Long COVID. | ACTIVE_NOT_RECRUITING | nan | King's College London | Physical Component Summary (PCS) of the 36-item Short Form Health Survey (SF-36) at Week 14 | EuroQol 5 Dimension - 5 Levels (EQ-5D-5L); Adult Service Use Schedule; Functional Assessment of Chronic Illness Therapy - Fatigue (FACIT-F); Modified Clinical Global Impressions Scale- Improvement (CGI-I); Pittsburgh Sleep Quality Index (PSQI); Modified Patien |
| NCT05791812 | Application of Direct Current Transcranial stImulation, Remotely superVised in Chronic fATiguE - Heimanwendung Der Transkraniellen Gleichstromstimulation Zur Behandlung Der Chronis | ACTIVE_NOT_RECRUITING | nan | University of Regensburg | Usability for the patients; Usability for the handlers/clinicians; Number of days out of 30 the patients used the device; Number of patients who completed the treatment regularly; Number of responders according the the clinical global impression change score f | Major Depression Inventory; World Health Organisation Quality of life scale (abbreviated Version) (WHOQOL-BREF); Clinical Global Impression change; Pittsburgh sleep quality index; numeric analogue scale pain; d2 test; digital span; Chalder fatigue scale; Bell |
| NCT06124625 | Effects of Rehabilitation Combined With a 12-week Maintenance Program Compared to Rehabilitation Alone in Post-COVID-19 - a Randomized, Controlled Trial. | ACTIVE_NOT_RECRUITING | nan | Schön Klinik Berchtesgadener Land | Change from baseline quality of life assessed by Short-Form 12 questionnaire at week 4 and week 19 | Change from baseline post-COVID-related symptoms at week 4 and week 19; Change from baseline lung function at week 4 and week 19; Change from baseline fatigue symptoms at week 4 and week 19; Change from baseline exercise capacity at week 4 and week 19; Change |
| NCT05719493 | Effectiveness and Health Benefits of a Nutritional, Chronobiological and Physical Exercise Primary Care Intervention in Fibromyalgia and Chronic Fatigue Syndrome: SYNCHRONIZE + Mix | ACTIVE_NOT_RECRUITING | nan | Fundacio d'Investigacio en Atencio Primaria Jordi Gol i Gurina | change in quality of life | change in fatigue indicator; change in sleep quality and insomnia indicator; change in pain indicator; change in adherence to the Mediterranean diet; change in physical exercise practice and sedentary lifestyle; change in circadian biological rhythm; change in |
| NCT06766825 | Phase II Proof-of-concept, Randomized, Double-blind, Placebo-controlled Study to Evaluate the Efficacy and Safety of Plitidepsin in Adults With Post-COVID-19 Condition (PCC) | RECRUITING | PHASE2 | Fundación FLS de Lucha Contra el Sida, las Enfermedades Infecciosas y la Promoción de la Salud y la Ciencia | Change in the overall health in patients from each group using patient reported outcomes measurement information system score (PROMIS-29®). | To compare the safety/tolerability of Plitidepsin Vs placebo in terms of adverse events in patients with PCC.; To compare the incidence of Treatment-Emergent Adverse Events (TEAEs) between groups.; To compare changes in the overall health in patients from each |
| NCT05167227 | The Long COVID and Fatiguing Illness Recovery Program - A Pragmatic, Quality Improvement, Professional Cluster, Randomized Controlled Trial. | ACTIVE_NOT_RECRUITING | nan | Family Health Centers of San Diego | Patient-Reported Outcomes Measurement Information System (PROMIS)-29 | Patient symptom checklist with associated severity for those present; If symptom is present, has patient experienced this in the past month; If symptom is present, how long has patient experienced this symptom; If symptom is present, did patient have this symp |
| NCT06251518 | Investigating the Effectiveness of Vimida, a Digital Intervention for People Suffering From Post-viral Chronic Fatigue After COVID-19 Infection | ACTIVE_NOT_RECRUITING | nan | Gaia AG | Fatigue symptom severity | Depressive symptoms; Health-related quality of life; Functioning; Somatic symptoms; Anxiety |
| NCT05764538 | DAOIB for the Treatment of Cognitive Impairment Induced by COVID-19 -An Open Trial | RECRUITING | PHASE2 | Chang Gung Memorial Hospital | Change from baseline in the Alzheimer's disease assessment scale - cognitive subscale at week 8, 16 and 24 | Change from baseline in Clinician's Interview-Based Impression of Change plus Caregiver Input score at week 8, 16 and 24; Change from baseline in Alzheimer's disease Cooperative Study scale for ADL in MCI (ADCS-MCI-ADL) score at week 8, 16 and 24; Ch |
| NCT05494424 | Cognitive Rehabilitation in Post-COVID-19 Condition: A Study Protocol for a Randomized Controlled Trial | ACTIVE_NOT_RECRUITING | nan | Lovisenberg Diakonale Hospital | The Metacognition Index from the Behavior Rating Inventory of Executive Function - Adult Version (BRIEF-A) | The Behaviour regulation Index from Behavior Rating Inventory of Executive Function - Adult Version (BRIEF-A); Cambridge Neuropsychological Test Automated Battery (CANTAB), subtests: Spatial Working Memory, Rapid Visual Information Processing, One Touch Stocki |
| NCT07021794 | Effectiveness of Treating Post-COVID-19 Conditions (Long COVID) With the SARS-CoV-2 Specific Monoclonal Antibody, Sipavibart | RECRUITING | PHASE2 | Nancy Klimas | Patient-Reported Outcomes Measurement Information System-29; Review of Treatment Related Adverse Events | Symptom-specific participant-reported outcome measures; Change in Simple Reaction Time (Milliseconds); Self-reported fatigue using MFI; Change in Heart Rate Post-6MWT; Processing Speed; Attention; Systolic Blood Pressure Response During NASA Lean Test; Diastol |
| NCT06655844 | Extended Home-use Trial of a Novel Device to Reduce Chronic Pain | RECRUITING | nan | Icahn School of Medicine at Mount Sinai | Neuropathic Pain Symptom Inventory | Pittsburgh Sleep Quality Index (PSQI); Beck Depression Inventory (BDI); General Anxiety Disorder 7-item questionnaire (GAD-7); Patient's Global Impression of Change (PGIC); Visual analogue scale (VAS)- Pain; Visual analogue scale (VAS)- Sleep |
| NCT06168006 | Effects of a Physical Training Program Using a Mobile App on the Functionality and Cardiovascular Function of Individuals With Post-covid-19 Syndrome: Randomized Clinical Trial | RECRUITING | nan | University of Nove de Julho | Change from baseline in 6 min-walk test distance at 12 weeks; Change from baseline in Glittre test at 12 weeks; Change from baseline in sit and stand test at 12 weeks; Change from baseline in Post-Covid Functional Scale at 12 weeks | Change from baseline in Patient Functional Scale at 12 weeks; Change from baseline in Motor Evoked Potential at 12 weeks; Change from baseline in Modified Medical Research Dyspnea Scale at 12 weeks; Change from baseline in Chalder Physical Fatigue Scale at 12 |
| NCT ID | Title | Status | Phase | Sponsor | Primary endpoint | Secondary endpoint |
|---|---|---|---|---|---|---|
| NCT05965726 | RECOVER-VITAL: A Platform Protocol for Evaluation of Interventions for Viral Persistence, Viral Reactivation, and Immune Dysregulation in Post-Acute Sequelae of SARS-CoV-2 Infectio | COMPLETED | PHASE2 | Kanecia Obie Zimmerman | Percentage of Participants Who Improved in Cognitive Dysfunction Symptom Cluster, as Measured by Patient-Reported Outcomes Measurement Information System (PROMIS) Cognitive 8a Function T-score; Percentage of Participants Who Improved in Autonomic Dysfunction S | Percentage of Participants Who Improved in Cognitive Dysfunction Symptom Cluster, as Measured by a Neurocognitive Battery; Percentage of Participants Who Improved in Autonomic Dysfunction Symptom Cluster, as Measured by the Active Stand Test; Percentage of Par |
| NCT05597722 | Randomized Study to Evaluate Strategies to Address Cognitive Fog in Long-COVID-19 Patients | TERMINATED | PHASE4 | Eva Szigethy | Change in Cognitive Impairment - MOCA; Change in Cognitive Impairment - BrainCheck; Change in Cognitive Impairment - ImPACT | Change in Depression - PHQ8; Change in Quality of Life - SWLS; Change in Disability |
| NCT05939622 | Prospective Randomized Double Blind Placebo Controlled Study of Efficacy of the Therapy With BRAINMAX® Using Functional Magnetic Resonance Imaging (fMRI) for the Treatment of Patie | COMPLETED | PHASE4 | Promomed, LLC | Changing patterns of brain activation using task fMRI with a cognitive paradigm | Asthenia on a scale Multidimensional Fatigue Inventory (MFI-20) after the completion of the parenteral therapy; Fatigue on a Fatigue Assessment Scale (FAS-10) scale after the completion of the parenteral therapy; Cognitive function on a Montreal Cognitive Asse |
| NCT04705831 | A Randomized, Double Blind, Placebo Controlled, Cross-Over, Proof-of-Concept Study to Evaluate the Benefit of RUCONEST (C1 Esterase Inhibitor [Recombinant]) in Improving Neurologic | COMPLETED | PHASE2 | IMMUNOe Research Centers | Neuropsychological Measures (BRIEF-A); Neuropsychological Measures (BRIEF-A); Neuropsychological Measures (BRIEF-A); Neuropsychological Measures (RBANS); Neuropsychological Measures (RBANS); Neuropsychological Measures (RBANS); Neuropsychological Measures (BDI | nan |
| NCT06055244 | Amantadine Therapy for Cognitive Impairment Related to Post-COVID Condition | COMPLETED | PHASE2 | Ohio State University | Improvement in cognitive symptoms; Improvement on objective cognitive testing | Mood symptoms; Medication tolerability |
| NCT06721949 | Taurine Supplementation as a Novel Therapeutic Approach for Neurocognitive Symptoms in Long COVID | RECRUITING | PHASE2; PHASE3 | University of Alberta | Mean change in Modified Fatigue Impact Scale (MFIS) from baseline to three months; Mean change in the ratio of the Trail-Making Tests A & B in the TestMyBrain cognitive testing battery from baseline to three months. | Core Outcome Set - Symptoms; Cardiovascular function; Respiratory function; Cognitive Function; Memory; Concentration; Conceptual Thinking; Social Functioning; Mental Health Status - PHQ-9; Mental Health Status - GAD-7; Post-Exertional Malaise (PEM) Symptoms; |
| NCT05196529 | Inspiratory Muscle Training in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) and COVID-19 Survivors | COMPLETED | nan | York University | Chemoreflex function; Clinical autonomic function; Vascular function; Cognitive function | Cardiorespiratory fitness; ME symptoms |
| NCT05571852 | Before-and-after Study on the Impact of a Home-based Personalized Computerized Training Program on Cognitive Dysfunction Associated With Long COVID | COMPLETED | nan | Universidad Antonio de Nebrija | Cognitive Gains | Intensity of the training |
| NCT05218174 | Exercise Training and Functional, Cognitive, and Emotional Well-being in Adults with Post-Acute Sequelae of SARS-CoV-2 (COVID-19) Infection (PASC): a Randomized Controlled Trial | COMPLETED | nan | Baylor Research Institute | Peak Oxygen Consumption (VO2max), mL/min; Peak Oxygen Consumption (VO2max), mL/min; Peak Oxygen Consumption (VO2max), mL/min; Score on Cognitive Function Self-Assessment Scale (CFSS); Score on Cognitive Function Self-Assessment Scale (CFSS); Score on Cognitive | Duration, mm:ss; Duration, mm:ss; Duration, mm:ss; Peak VO2 (absolute), mL/min; Peak VO2 (absolute), mL/min; Peak VO2 (absolute), mL/min; Peak VO2 (relative), mL/kg/min; Peak VO2 (relative), mL/kg/min; Peak VO2 (relative), mL/kg/min; Metabolic Equivalents; Met |
| NCT06315894 | Design and Implementation of a Supervised Computerized Active Program (SuperCAP) for Improvement of Cognitive, Emotional, and Functional Status in People With Post-COVID Syndrome. | COMPLETED | nan | Fundación FLS de Lucha Contra el Sida, las Enfermedades Infecciosas y la Promoción de la Salud y la Ciencia | Change in Self-reported Cognitive Functioning | Change in Performance-based Cognitive Functioning; Change in Depression Symptoms; Change in Anxiety Symptoms; Change in Daily Activities Functioning; Change in Physical Activity; Change in Quality of Life |
| NCT07184398 | Use of a Cysteine-rich Whey Protein Isolate (Immunocal®) in Post COVID-19 Cognitive Impairment | COMPLETED | nan | Universidad Libre seccional Cali | Change in Cognitive Function | Change in Functional Capacity (Sit-to-Stand Test) |
| NCT05965739 | RECOVER-NEURO: A Platform Protocol for Evaluation of Interventions for Cognitive Dysfunction in Post-Acute Sequelae of SARS-CoV-2 Infection (PASC) | COMPLETED | nan | Duke University | Change in Everyday Cognition 2 (ECog2) | Change in PROMIS-cognitive function - short form 8a (PROMIS-Cog) total score; Change on an objective neurocognitive battery scores; Change in Everyday Cognition 2 (ECog2); Characterize the intervention's safety as measured by the proportion of Serious Adv |
| NCT05841498 | A Single-blinded Sham-controlled Crossover Trial to Evaluate the Effect of Immunoadsorption on Post-Corona Virus Disease (COVID)-Syndrome | COMPLETED | nan | University Medical Center Mainz | Improvement of Post-COVID symptoms as measured by PCFS score; Change of physical and/or mental fatigue as measured by Chalder-Fatigue-scale; Change of impairment due to fatigue as measured by Bell-Score; Change of physical and/or mental fatigue as measured by | number of treatment-emergent adverse events (TEAE), serious adverse events and discontinuation of therapy because of adverse events; Prevalence of anti-adrenergic and anti-muscarinic autoantibodies in patients with PCS:; 3. Concentration of autoantibodies befo |
| NCT05531019 | COVID-19 Sequelae: Treatment and Monitoring of Persistent Symptoms, a Decentralized Approach Focus on the Patient. Use of Dietary Supplement Based on Sea Urchin Eggs With Echinochr | COMPLETED | nan | Fernando Saldarini | Change of symptoms over time-points (baseline, 4 weeks, 8 weeks, 12 weeks) during rutine medical checkup.; Change of lung capacity over four times (baseline, 4 weeks, 8 weeks, 12 weeks) assessed during spirometry.; Change of walking distance during a six minut | Change of Von Willebrand Factor over time-points (baseline, 4 weeks, 12 weeks, 12 weeks) via blood sample.; Change of D Dimer over time-points (baseline, 4 weeks, 12 weeks, 12 weeks) via blood sample.; Change of HS-CRP over time-points (baseline, 4 weeks, 8 we |
| NCT04950725 | Covid-19 Virtual Recovery Study | COMPLETED | nan | Mayo Clinic | Change in Phonation time; Change in Sit to stand executions; Change in number of reported COVID symptoms; Change in breathing difficulty; Change in reported affect of health on physical activity; Change in reported cognition | nan |
| NCT05664711 | Effect of Stellate Ganglion Block on ME/CFS Symptoms and Metabolites | COMPLETED | PHASE1 | Neuroversion, Inc. | Change in Subjective Rating of Symptoms at 2 Weeks; Change in Subjective Rating of Symptoms at 2 Months; Change in Cognitive Function at 2 Weeks; Change in Cognitive Function at 2 Months | Change in Orthostatic Tolerance at 2 Weeks; Change in Orthostatic Tolerance at 2 Months; Change in Autonomic Tone at 2 Weeks; Change in Autonomic Tone at 2 Months |
| NCT06251011 | Effects of Physiotherapy Via Telerehabilitation on Cardiopulmonary, Physical, and Psychological Functions in Patients With COVID-19: A Randomized Controlled Trial | COMPLETED | nan | Chulabhorn Hospital | Cardiopulmonary function; Patient's quality of life; Functional capacity; Anxiety and depression; Insomnia; Cognitive function; Muscle strength | nan |
| NCT06695910 | Modulation of the Brain Fog Scale by Eicosapentaenoic Acid Monoglycerides (MAG-EPA) in Volunteers Who Reported Suffering From Haze or Mental Fatigue on a Regular Basis. Exploratory | RECRUITING | PHASE4 | Samuel Fortin | Cognitive health assessment with the Brain Fog Scale (BFS) | Omega-3 intake assessment by Omega-3 index analysis; Demographic data analysis; Adverse Event reporting |
| NCT06631287 | Randomized Double-Blind Placebo-Controlled Trial EValuating Baricitinib on PERSistent NEurologic and Cardiopulmonary Symptoms of Long COVID (REVERSE-LC) | RECRUITING | PHASE3 | Wes Ely | CNS-Vital Signs Global Cognitive Index | Objective neuropsychological function domains of executive function, memory, processing speed, and motor speed including the CNS-Vital Signs subscale tests at 6-months.; Objective neuropsychological function domains of executive function, memory, processing sp |
| NCT06847191 | A Double-blind, Randomized Study to Evaluate the Efficacy and Safety of Bezisterim (NE3107) in Adults With Long COVID | ACTIVE_NOT_RECRUITING | PHASE2 | BioVie Inc. | Change from Baseline in performance on the Cogstate Cognition battery* | Change from Baseline in PROMIS Cognitive Function Short Form 8a (SF-8a); Change from Baseline in PROMIS Fatigue Short Form 13a (SF-13a); Change from Baseline in PROMIS Sleep Disturbance Short Form 8a (SF-8a); Change from Baseline in SF-12 Health Survey (Physic |
| NCT05846126 | Digital Rehabilitation With Cognitive Training, Physical Activity and Mindfulness for People With Post-acute COVID-19 Syndrome With Cognitive Impairment. REHABCOVID Project. | COMPLETED | nan | Consorci Sanitari de Terrassa | Differences between groups in scores of global cognition; Differences between groups in scores of selective attention, inhibition, and processing speed; Differences between groups in scores of Visual scanning and processing speed; Differences between groups in | Differences between groups in scores of anxiety; Differences between groups in scores of depression; Differences between groups in scores of Mindfulness levels; Differences between groups in scores of Fatigue; Differences between groups in scores of psychologi |
| NCT06391489 | Piloting A Telehealth Deliverable Self-Management and Cognitive Training Program (HOBSCOTCH, HOme Based Self-Management and COgnitive Training CHanges Lives) for People With Post A | ACTIVE_NOT_RECRUITING | nan | Dartmouth-Hitchcock Medical Center | Change in overall quality of life as measured by comparing PROMIS-10 Global Health scores pre- and post-HOBSCOTCH-PACS intervention.; Change in subjective cognition as measured by comparing Neuro-QOL Item Bank v2.0 Cognitive Function scores pre- and post-HOBSC | Change in objective cognition as measured by comparing Symbol-Digit Modalities Test scores pre- and post-HOBSCOTCH-PACS intervention.; Change in objective cognition as measured by comparing California Verbal Learning Test-III scores pre- and post-HOBSCOTCH-PAC |
| NCT06821087 | Evaluating the Neuromodulatory Effect of Ketamine in Long COVID: A Pilot Study Targeting Fatigue and Neurocognitive Symptoms | ENROLLING_BY_INVITATION | PHASE2 | University of Texas at Austin | PROMIS SF v1.0 - Fatigue 8a; PROMIS SF v2.0 Cognitive Function 4a; BrainCheck Cognitive Battery; Number of participants with treatment-related adverse events as assessed by standardized interview | PROMIS Global 10 v1.2; NASA Task Load Index (NASA-TLX); Patient Health Questionnaire-9 (PHQ-9); Generalized Anxiety Disorder-7 (GAD-7); Depression in Medically Ill 10 Scale (DMI-10); Long COVID Review of Systems; Neuroimaging (MRI) Outcomes; Serum Biomarker An |
| NCT04137757 | Neural Correlates of Cognitive Dysfunction in Postural Tachycardia Syndrome | ACTIVE_NOT_RECRUITING | nan | Milton S. Hershey Medical Center | Cognitive Brain Region Activation | Brain Oxygen Perfusion; Blood Pressure; Heart Rate; Stroop Word-Color Score |
| NCT05764538 | DAOIB for the Treatment of Cognitive Impairment Induced by COVID-19 -An Open Trial | RECRUITING | PHASE2 | Chang Gung Memorial Hospital | Change from baseline in the Alzheimer's disease assessment scale - cognitive subscale at week 8, 16 and 24 | Change from baseline in Clinician's Interview-Based Impression of Change plus Caregiver Input score at week 8, 16 and 24; Change from baseline in Alzheimer's disease Cooperative Study scale for ADL in MCI (ADCS-MCI-ADL) score at week 8, 16 and 24; Ch |
| NCT05494424 | Cognitive Rehabilitation in Post-COVID-19 Condition: A Study Protocol for a Randomized Controlled Trial | ACTIVE_NOT_RECRUITING | nan | Lovisenberg Diakonale Hospital | The Metacognition Index from the Behavior Rating Inventory of Executive Function - Adult Version (BRIEF-A) | The Behaviour regulation Index from Behavior Rating Inventory of Executive Function - Adult Version (BRIEF-A); Cambridge Neuropsychological Test Automated Battery (CANTAB), subtests: Spatial Working Memory, Rapid Visual Information Processing, One Touch Stocki |
| NCT06876948 | STUDY of NEUROLOGICAL COMPLICATIONS of LONG COVID-19 in CHILDREN and ADOLESCENTS; NEUROPSYCHIATRIC, ELECTROENCEPHALOGRAPHIC and NEURORADIOLOGICAL INVESTIGATIONS | RECRUITING | nan | Azienda Ospedaliero, Universitaria Pisana | Changes in cognitive and neuropsychological functions in children and adolescents with Long COVID between T0 and T1. | nan |
| NCT06633666 | Acupuncture for Long COVID Neuropsychiatric Symptoms: a Pragmatic,Randomized Clinical Trial | RECRUITING | nan | Hong Kong Baptist University | Cognitive score on the Chinese version of the Mini-Mental State Examination (MMSE) scale | Depression on the Chinese Beck Depression Inventory (CBDI); Score of Insomnia Severity Index (ISI); Score of Brief Fatigue Inventory-Taiwanese (BFI-T) Form; Hamilton Depression Scale (HAMD); Hamilton Anxiety Rating Scale (HAMA); Traditional Chinese Medicine Sy |
| NCT06871293 | Impact of Functional and Cognitive Rehabilitation, in Adults With Chronic Noncommunicable Diseases and Long Covid-19 , on Their Functional and Cognitive Capacity, Quality of Life, | RECRUITING | nan | Fundación Cardioinfantil Instituto de Cardiología | Composite Change in Functional Capacity, Cognitive Function, Health-Related Quality of Life, and Strength | Change in Functional Capacity; Change in Cognitive Function; Change in Health-Related Quality of Life; Change in Health-Related Quality of Life, Visual Analogue Scale; Change in Handgrip Strength, Hydraulic Dynamometer; Incidence of Chronic Disease Decompensat |
| NCT06234462 | Feasibility Study of Amantadine for Cognitive Dysfunction in Patients With Long-Covid: A Pilot Randomized Control Trial | WITHDRAWN | PHASE2 | University of Texas Southwestern Medical Center | Measures of cognitive functioning; Measures of cognitive functioning; Measures of cognitive functioning; Measures of cognitive functioning; Measures of cognitive functioning; Measures of cognitive functioning | Measures of endurance and strength; Measures of endurance and strength; Measures of endurance and strength; Measures of endurance and strength; Measures of fatigue; Measures of anxiety and depression; Measures of anxiety and depression; Measures of anxiety and |
| NCT07355751 | The Effect of Acupuncture Treatment on Cognitive Functions and Brain Networks for Long COVID: a Multimodal Magnetic Resonance Imaging Study | NOT_YET_RECRUITING | nan | Tingting Luo | Change of Addenbrooke's Cognitive Examination-III total score from baseline to the end of 8 weeks; Change of Phonemic Fluency Test score from baseline to the end of 8 weeks | Changes of Digit Span Test scores from baseline to the end of 8 weeks; Change of Symbol Digit Modality Test score from baseline to the end of 8 weeks; Changes of Trail Making Test scores from baseline to the end of 8 weeks; Changes of Rey Auditory Verbal Learn |
| NCT06074848 | Transcranial Direct Current Stimulation as a Strategy for the Management of Disorders Generated by COVID-19: a Multicentric Study. | UNKNOWN | PHASE2 | Universidade Federal de Pernambuco | Fatigue - Modified Fatigue Impact Scale (MFIS); Pain measure - Brief Pain Inventory (BPI); Pain measure - Visual Analog Scale (VAS); Cognitive deficit - Montreal Cognitive Assessment Instrument (MoCA); Cognitive deficit - FAS Test; Cognitive deficit - CFL Test | COVID clinical situation; Level of physical activity; State of strength and effort; Exercise capacity - 6-minute walk test; Immunometabolic evaluation |
| NCT05234281 | Concentrated Cross-disciplinary Group Intervention for Common Health Complaints (Mixed Anxiety Depression, Diabetes Mellitus Type 2, Low Back Pain, Chronic Obstructive Pulmonary Di | UNKNOWN | nan | Helse i Hardanger | Completion rates; Patient satisfaction; Changes to cognitive and emotional perception of illness; Changes in level of patient activation | Changes in level of functioning |
| NCT05589272 | TDCS-potentiated Generalization of Cognitive Training in the Rehabilitation of Long COVID Symptoms | WITHDRAWN | nan | University of Minnesota | Cognitive improvement effects of WM training with active tDCS vs. sham; Generalization of cognitive effects of active tDCS vs. sham | nan |
| NCT06144320 | The Objective of Our Study is to Evaluate the Medium and Long-term Clinical Efficacy of Acupuncture in Patients With Post Covid Related Mild Cognitive Impairment (MCI). | UNKNOWN | nan | China Medical University Hospital | cognitive function | Concentration difficulty |
| NCT06042777 | Testing Non-pharmacological TCM-based Treatments for Cognitive Impairment in People With Long COVID Symptoms: A Randomized Controlled Trial | UNKNOWN | nan | The Hong Kong Polytechnic University | Global cognitive function | Global cognitive function; Cardiopulmonary function; Fatigue; Health-related quality-of-life; Psychological distress; Neurocognitive functions; Neurobiological outcomes |
| NCT05890508 | Electro-acupuncture for Long Covid Neuropsychiatric Symptoms: a Prospective, Randomized Sham-controlled, Double-blinded Clinical Trial | UNKNOWN | nan | Hong Kong Baptist University | Cognitive score on the Chinese version of the Mini-Mental State Examination (MMSE) scale; Depression on the Chinese Beck Depression Inventory (CBDI) | Score of Insomnia Severity Index (ISI); Score of Brief Fatigue Inventory-Taiwanese (BFI-T) Form; Score of the Short Form 12 (SF12) |
| NCT05947617 | Phase 1 Study: Assessing VIX001 Safety, Efficacy, and Dosing in Post Acute COVID-19 Syndrome (PACS) Patients With Neurological Symptoms and Cognitive Impairment. | UNKNOWN | PHASE1 | Neobiosis, LLC | Change from Baseline Six Minute Walk Test (6MWT) with oximetry.; Change from Baseline Transthoracic Echocardiogram in 3 Dimensions (3-D TTE).; Change from Baseline Pulmonary Function Test (PFT) with bronchodilation if abnormal.; Change from Baseline Sleep time | PROMIS; mMRC Scale.; General Anxiety Disorder (GAD-7).; Personal Health Questionnaire Depression Scale (PHQ-8). |
| NCT05419219 | Effectiveness of Multi-domain Tai Chi Digital Therapy for Survivors Affected by the Sequelae of Covid-19 (TaiChi-DTx and Long Covid) | UNKNOWN | nan | Tim Shi | Change in Physical Activity ability measured by 6-minute walking distance measurement (6MWT); Overall respiratory relief measured by the Post-COVID-19 Functional Status (PCFS) Scale; Cognitive impairment improvement measured by the well-validated neuropsycholo | Change in number of hours/days absent from work related to Long COVID symptoms survey by web-based questionnaires (time frame 6 months after SARS-CoV-2 infection) |
| NCT04898205 | Cardiopulmonary Rehabilitation in COVID-19 Longhaulers | UNKNOWN | nan | Noah Greenspan | Heart rate and rhythm response to exercise and positional changes; Blood pressure response to exercise and positional changes; Activity metabolic equivalent of task (MET) tolerated; Breathlessness; Rate of perceived exertion (RPE); Cognition (attention, short, | Depression; Generalized anxiety; State anxiety; Trait anxiety; Improvement in quality of life; Perception of cognitive function |
| NCT06391970 | Exploring Long-COVID Impact on Cognition Through Digital Neuropsychological Assessment | UNKNOWN | nan | Luxembourg Institute of Health | Cognitive status assessed with the digital device, of individuals with/without symptoms persisting long-term after COVID-19 disease.; Cognitive status assessed with the gold standard procedure, of individuals with/without symptoms persisting long-term after CO | nan |
| NCT06348212 | Effect of Probiotic Strain Lactobacillus Paracasei PS23 on Brain Fog in People With Long COVID | UNKNOWN | nan | Taipei Veterans General Hospital, Taiwan | Long covid related symptoms; Hospital Anxiety and Depression Scale; The Pittsburgh sleep quality index; Fatigue Severity Scale; GI symptoms; Cognitive function-Digit symbol substitution test; Cognitive function-The Montreal Cognitive Assessment(MoCA); Cognitiv | nan |
| NCT ID | Title | Status | Phase | Sponsor | Primary endpoint | Secondary endpoint |
|---|---|---|---|---|---|---|
| NCT05633407 | A Phase 2 Randomized, Double-blinded, Placebo-controlled Study to Evaluate the Efficacy and Safety of Efgartigimod IV in Adult Patients With Post-COVID-19 Postural Orthostatic Tach | COMPLETED | PHASE2 | argenx | Change From Baseline to Week 24 in the COMPASS 31 (2-week Recall Version); Change From Baseline to Week 24 in the MaPS; Number of Participants With TEAEs and TESAEs | Percentage of Participants With Improved PGI-S at Week 24; Percentage of Participants With Improved in PGI-C at Week 24; Change From Baseline to Week 24 in the PROMIS Fatigue Short Form 8a; Change From Baseline to Week 24 in the PROMIS Cognitive Function Short |
| NCT04920916 | Safety and Efficacy of the Treatment of Hospitalized Patients With COVID 19 Infection With an Inhibitor of IL-4 and IL-13 Signaling: A Phase IIa Trial | COMPLETED | PHASE2 | University of Virginia | Day 28 Ventilator Free Survival; Follow up Study 1 Year Outcome: Pulmonary Function Testing- Oxygen Diffusion and 6 Minute Walk Testing | Proportion of Patients With Eosinophilia; Cumulative Incidence of Grade 3 and 4 Clinical Adverse Events, Serious Adverse Events (SAEs) or Death; SARS-CoV-2 Variants; Change in Plasma Total Immunoglobulin E (IgE) Levels; Change in C-reactive Protein (CRP); Chan |
| NCT05592418 | A Randomized, Double Blind, Placebo Controlled Study to Evaluate the Efficacy and Safety of Ampligen® in Patients With Post-COVID Conditions | COMPLETED | PHASE2 | AIM ImmunoTech Inc. | Change From Baseline to Week 13 in PROMIS Fatigue Score (T-Score) | Change From Baseline to Week 6 in PROMIS Fatigue Score (T-Score); Change From Baseline to Week 13 in PROMIS Fatigue Score (T-Score), Excluding Response to Item Seven; Change From Baseline to Week 6 and Week 13 in Distance Traveled During 6-minute Walk Test (6M |
| NCT05576662 | Selective Trial Of Paxlovid for PASC (STOP-PASC): Randomized Double-Blind Placebo-Controlled Pilot Trial of Paxlovid for the Treatment of PASC | COMPLETED | PHASE2 | Stanford University | Number of Participants With No, Mild, Moderate, or Severe Symptoms at Week 10 According to the Core Symptoms Severity Scale Score | Number of Participants With No, Mild, Moderate, or Severe Symptoms at Day 15 According to the Core Symptoms Severity Scale Score; Number of Participants Reporting Relief of at Least One Core Symptom for 2 Weeks; Number of Participants With Overall Alleviation |
| NCT05965726 | RECOVER-VITAL: A Platform Protocol for Evaluation of Interventions for Viral Persistence, Viral Reactivation, and Immune Dysregulation in Post-Acute Sequelae of SARS-CoV-2 Infectio | COMPLETED | PHASE2 | Kanecia Obie Zimmerman | Percentage of Participants Who Improved in Cognitive Dysfunction Symptom Cluster, as Measured by Patient-Reported Outcomes Measurement Information System (PROMIS) Cognitive 8a Function T-score; Percentage of Participants Who Improved in Autonomic Dysfunction S | Percentage of Participants Who Improved in Cognitive Dysfunction Symptom Cluster, as Measured by a Neurocognitive Battery; Percentage of Participants Who Improved in Autonomic Dysfunction Symptom Cluster, as Measured by the Active Stand Test; Percentage of Par |
| NCT05472090 | A Phase 2, 14-week Double-Blind, Randomized, Multicenter, Placebo-Controlled Study to Evaluate the Efficacy and Safety of TNX-102 SL Taken Daily at Bedtime in Patients With Multisi | COMPLETED | PHASE2 | Tonix Pharmaceuticals, Inc. | Daily Diary Pain NRS | Daily Diary Sleep Quality NRS; PROMIS Fatigue -Short Form 8a; PROMIS Cognitive Function - Abilities-Short Form 8a |
| NCT06136871 | Cognitive Strategy Training in Post-COVID-19 Syndrome: A Feasibility Trial | COMPLETED | nan | University of Missouri-Columbia | Recruitment Rate; Retention Rate; Telehealth Usability Questionnaire (TUQ); Acceptability of Intervention Measure (AIM); Intervention Appropriateness Measure (IAM); Feasibility of Intervention Measure (FIM); Canadian Occupational Performance Measure (COPM) Per | Delis-Kaplan Executive Function System (DKEFS)- Color-Word Interference, Age-Corrected Time; Delis-Kaplan Executive Function System (DKEFS)- Color-Word Interference, Age-Corrected Errors; Patient-Reported Outcomes Measurement Information System (PROMIS) Cognit |
| NCT06476496 | Pain Relief With Integrative Medicine (PRIMe)?: Feasibility of Acupuncture for Long COVID | COMPLETED | nan | University of Washington | Pain, Enjoyment and General Activity (PEG) | Pain Catastrophizing Scale (PCS) Short Form; PROMIS-29; PROMIS Cognitive Function; UW Pain Related Self-Efficacy Scale (PRSE) |
| NCT05877508 | An Exploratory, Randomized, Double-Blind Placebo-Controlled Study to Assess the Safety of an Anti-SARS-CoV-2 Monoclonal Antibody and Response to Treatment in Individuals With Long | ACTIVE_NOT_RECRUITING | PHASE2 | Michael Peluso, MD | Patient-Reported Outcomes Measurement Information System (PROMIS)-29 Physical Health Summary Score | Patient-Reported Outcomes Measurement Information System (PROMIS)-29 Physical Health Summary Score; Patient-Reported Outcomes Measurement Information System (PROMIS)-29 Mental Health Summary Score; Patient-Reported Outcomes Measurement Information System (PROM |
| NCT06161688 | Placebo-Controlled, Randomized Trial of Ensitrelvir (S-217622) for Viral Persistence and Inflammation in People Experiencing Long COVID (PREVAIL-LC) | ACTIVE_NOT_RECRUITING | PHASE2 | Timothy Henrich | Patient-Reported Outcomes Measurement Information System (PROMIS)-29 Physical Health Summary Score | Patient-Reported Outcomes Measurement Information System (PROMIS)-29 Physical Health Summary Score; Patient-Reported Outcomes Measurement Information System (PROMIS)-29 Mental Health Summary Score; Patient-Reported Outcomes Measurement Information System (PROM |
| NCT05092516 | Home-based Transcranial Direct Current Stimulation (tDCS) for Treatment of Cognitive Post-acute Sequelae of COVID-19 (PASC) | ACTIVE_NOT_RECRUITING | nan | Massachusetts General Hospital | Inhibitory Control; Inhibitory Control; Processing Speed; Processing Speed; EEG P300 Event-related Potential; EEG P300 Event-related Potential | Cognitive Flexibility; Cognitive Flexibility; Working Memory; Working Memory; Episodic Memory; Episodic Memory |
| NCT04938687 | Pilot, Effect of Respiratory-Gated Auricular Vagal Afferent Nerve Stimulation (RAVANS) on Post-Treatment Lyme Disease Syndrome | COMPLETED | nan | Spaulding Rehabilitation Hospital | Horowitz Lyme-Multiple Systemic Infectious Disease Syndrome Questionnaire | Sedentary Behaviors Questionnaire; Fatigue Symptom Inventory; Brief Pain Inventory-Pain 24 Hours; Beck Depression Inventory; Beck Anxiety Inventory; Pittsburgh Sleep Quality Index; Timed Up and Go; Time to Complete 4 Meters at Usual Walking Speed,; NIH Toolbox |
| NCT05918978 | Open-Label Extension Study to Evaluate the Long-term Safety and Efficacy of Efgartigimod in Adult Patients With Post-COVID-19 Postural Orthostatic Tachycardia Syndrome (PC-POTS) Wh | TERMINATED | PHASE2 | argenx | Number of Participants With TEAEs, TESAEs and TEAESIs | Change From Baseline to Weeks 24 and 48 in the COMPASS 31 (2-week Recall Version); Change From Baseline to Weeks 24 and 48 in the MaPS; Percentage of Participants With Improved PGI-S at Weeks 24 and 48; Percentage of Participants With Improved PGI-C at Weeks 2 |
| NCT05513560 | REcovering From COVID-19 Lingering Symptoms Adaptive Integrative Medicine (RECLAIM) | COMPLETED | PHASE2; PHASE3 | University Health Network, Toronto | SF-36 physical component score (PCS) | Symptoms scale; Symptom Checklist; Six Minute Walking Test (6MWT) with oximetry; TestMyBrain cognitive testing; Post COVID19 functional status scale; Reintegration to Normal Living Index (RNLI); Fatigue Scale; Brief Fatigue inventory; Post-Exertional Malaise; |
| NCT05939622 | Prospective Randomized Double Blind Placebo Controlled Study of Efficacy of the Therapy With BRAINMAX® Using Functional Magnetic Resonance Imaging (fMRI) for the Treatment of Patie | COMPLETED | PHASE4 | Promomed, LLC | Changing patterns of brain activation using task fMRI with a cognitive paradigm | Asthenia on a scale Multidimensional Fatigue Inventory (MFI-20) after the completion of the parenteral therapy; Fatigue on a Fatigue Assessment Scale (FAS-10) scale after the completion of the parenteral therapy; Cognitive function on a Montreal Cognitive Asse |
| NCT04795557 | Effect of ADAPT232 Supplementation on Recovery of Patients in Rehabilitation Period in Long COVID-19: a Randomized, Double-blind, Placebo-controlled Trial | COMPLETED | PHASE2; PHASE3 | Swedish Herbal Institute AB | Duration of symptoms of Long COVID:; Number of participants clinically recovered; Length of home stay/ sick listed; Severity of the Long COVID symptoms | Hypercoagulation marker; Immune response marker; Inflammatory marker; Physical activity; Cognitive performance score; Severity of anxiety and depression; Severity of anxiety |
| NCT05890534 | Pycnogenol® in People With Post-COVID-19 Condition: a Quadruple-blind, Randomized, Placebo-controlled Trial | COMPLETED | PHASE3 | University of Zurich | Health status (EQ-VAS) | Post COVID-19 symptoms; Fatigue; Dyspnea; Cognitive function; Anxiety and depression; Health-related quality of life (EQ-5D-5L); Functional exercise capacity; Physical activity; Soluble Thrombomodulin (sTM); von Willebrand Factor antigen (VWF:Ag); Syndecan-1; |
| NCT06404112 | RECOVER-SLEEP: A Platform Protocol for Evaluation of Interventions for Sleep Disturbances in Post-Acute Sequelae of SARS-CoV-2 Infection (PASC) | COMPLETED | PHASE2 | Duke University | Change in total score of the PROMIS 8b SD to assess sleep disturbance; Change in sleep onset variability, assessed using a wearable device | Change in total score of the PROMIS 8a SRI to assess sleep-related impairment; Change in PROMIS 10a Fatigue score; Change in an objective neurocognitive battery score; Change in ECog2 measure; Change in PASC Symptom Questionnaire responses; Change in total sco |
| NCT05668091 | An Interventional Decentralized Phase 2, Randomized, Double-Blind, 2-Arm Study to Investigate the Efficacy and Safety of Orally Administered Nirmatrelvir/Ritonavir Compared with Pl | COMPLETED | PHASE2 | Harlan M Krumholz | National Institutes of Health (NIH) Patient-Reported Outcomes Measurement Information System (PROMIS)-29 version 2.1 Physical Health Summary Score | Modified General Symptom Questionnaire-30 (Modified GSQ-30); PROMIS® Cognitive Function v.2.0 - Short Form 6a; COVID Core Outcome Measure for Recovery; EuroQol EQ-5D-5L Utility Score-VAS (USA Version); Functional Assessment of Chronic Illness Therapy (FACIT)-I |
| NCT06404099 | RECOVER-SLEEP: A Platform Protocol for Evaluation of Interventions for Sleep Disturbances in Post-Acute Sequelae of SARS-CoV-2 Infection (PASC) | COMPLETED | PHASE2 | Duke University | Change in total score of the PROMIS 8a SRI to assess sleep-related impairment | Change in total score of the PROMIS 8b SD to assess sleep disturbance; Change in PROMIS 10a Fatigue score; Change in an objective neurocognitive battery score; Change in ECog2 measure; Change in PASC Symptom Questionnaire responses; Change in total score on th |
| NCT05823896 | An Interventional, Double-Blinded, 2-Arm Study to Investigate the Efficacy of Orally Administered Nirmatrelvir/Ritonavir Compared with Placebo/Ritonavir in Non-hospitalized Adult P | COMPLETED | PHASE2 | Karolinska Institutet | Change from baseline in quality of life over time | Change from baseline in quality of life over time; Change from baseline in hemodynamic response over time; Change from baseline in dysautonomia over time; Change from baseline in fever in patients with POTS over time; Change from baseline in endothelial functi |
| NCT05497089 | Temelimab as a Disease Modifying Therapy in Patients With Neurological, Neuropsychological, and Psychiatric (=Neuropsychiatric) Symptoms in Post-COVID 19 or Postacute Sequelae of C | COMPLETED | PHASE2 | GeNeuro SA | Improvement in fatigue in PASC patients | Fatigue; Cognitive function; Cognitive function; Cognitive function; Cognitive function; Anxiety; Depression; Overall quality of Life; Functional impairment; Post-COVID-19 Functional Status; Safety and tolerability of Temelimab in PASC patients |
| NCT05445674 | Plasma Exchange Therapy for Post- COVID-19 Condition: A Pilot, Randomized Double-Blind Study | COMPLETED | PHASE2 | Fundación FLS de Lucha Contra el Sida, las Enfermedades Infecciosas y la Promoción de la Salud y la Ciencia | Evaluate the safety and tolerability of PE in patients with Post-Acute Covid-19 Syndrome (PCC) comparing to sham plasma exchange (placebo); Proportion of subjects with Grade 0, 1 o 2 functional disability assessed by the functional status scale (PCFS); Proport | Assess the ability of PE to improve PCC symptoms; Assess the impact of PE on quality of life in subjects with PCC; Assess the impact of PE on quality of life in subjects with PCC using MOS-HIV questionnaire; Assess the impact of PE on neurocognitive symptoms i |
| NCT06223971 | A Phase l Study to Assess the Safety and Tolerability of PET Imaging With [11 C]CPPC [5-cyano-N-( 4-( 4-[l l CJ me1hylpiperazin-l-yl)-2-(Piperidin-l-yl)Phenyl)Furan-2-carboxamide] | COMPLETED | EARLY_PHASE1 | Johns Hopkins University | To assess the safety and tolerability of one dose level of [11C]CPPC when administered intravenously.; Safety of use of [11C]CPPC in patients with Long-COVID and healthy participants with history of COVID-19 infection as assessed by a change in complete blood | Biodistribution of [11C]CPPC by PET imaging; Cognitive function as assessed by the NIH Toolbox Cognition Battery (NIHTB-CB); Neuro-psychological assessment as assessed by the The Rey-Osterrieth complex figure test (ROCF); Global cognitive function as assessed |
| NCT06721949 | Taurine Supplementation as a Novel Therapeutic Approach for Neurocognitive Symptoms in Long COVID | RECRUITING | PHASE2; PHASE3 | University of Alberta | Mean change in Modified Fatigue Impact Scale (MFIS) from baseline to three months; Mean change in the ratio of the Trail-Making Tests A & B in the TestMyBrain cognitive testing battery from baseline to three months. | Core Outcome Set - Symptoms; Cardiovascular function; Respiratory function; Cognitive Function; Memory; Concentration; Conceptual Thinking; Social Functioning; Mental Health Status - PHQ-9; Mental Health Status - GAD-7; Post-Exertional Malaise (PEM) Symptoms; |
| NCT06974058 | Evaluation of a Quercetin/Curcumin-Based Supplement for Mild to Moderate Long COVID-19 Symptoms: A Pragmatic, Interventional Clinical Study. | COMPLETED | nan | Liaquat University of Medical & Health Sciences | Change in Overall Symptom Burden | Change in Functional Status and Quality of Life (SF-36 Scores); Change in the Need for Prescribed Medications or NSAIDs (Non-Steroidal Anti-Inflammatory Drugs); Change in Pain Severity and Pain Interference (Brief Pain Inventory - Short Form); Change in Fatigu |
| NCT06315894 | Design and Implementation of a Supervised Computerized Active Program (SuperCAP) for Improvement of Cognitive, Emotional, and Functional Status in People With Post-COVID Syndrome. | COMPLETED | nan | Fundación FLS de Lucha Contra el Sida, las Enfermedades Infecciosas y la Promoción de la Salud y la Ciencia | Change in Self-reported Cognitive Functioning | Change in Performance-based Cognitive Functioning; Change in Depression Symptoms; Change in Anxiety Symptoms; Change in Daily Activities Functioning; Change in Physical Activity; Change in Quality of Life |
| NCT05855369 | A Randomized Controlled Trial of Smell Training and Trigeminal Nerve Stimulation in the Treatment of COVID-related Persistent Smell Loss | RECRUITING | PHASE2; PHASE3 | Medical University of South Carolina | Change in Psychophysical Olfactory Function from Baseline to 4 and 12 Weeks; Change in Perceived Intensity of Odorants from Baseline to 4 and 12 Weeks; Change in Perceived Hedonics of Odorants from Baseline to 4 and 12 Weeks; Change in Olfactory-related Qualit | Change in Long COVID Symptoms from Baseline to 4 and 12 Weeks; Change in Sustained Attention from Baseline to 4 and 12 Weeks; Change in Cognitive Function from Baseline to 4 and 12 Weeks; Change in Mood State from Baseline to 4 and 12 Weeks; Change in Sleep Qu |
| NCT05710770 | Double-blinded, Randomized, Sham-controlled Trial of Immunoadsorption (IA) in Patients With Chronic Fatigue Syndrome (CFS) Including Patients With Post-acute COVID-19 CFS (PACS-CFS | COMPLETED | nan | Charite University, Berlin, Germany | Improvement in physical and mental fatigue as measured by the Chalder Fatigue Scale | Sustained improvement quantified by the Chalder Fatigue Scale; Verification of safety and tolerability of immunoadsorption in this patient population; Improvement in severity of symptoms of chronic fatigue syndrome (CFS) as measured by the Fluge score; Improve |
| NCT07280572 | RECLAIM: an Adaptive Platform Trial for the Evaluation of Treatments for Post-Acute Sequelae of SARS-CoV-2 Infection (PASC) | ENROLLING_BY_INVITATION | PHASE3 | Janneke van de Wijgert | Physical health-related quality of life (HRQoL) | Mental HRQoL; Other aspects of HRQoL; Fatigue; Post Exertional Malaise (PEM); Cognitive functioning; Post Orthostatic Tachycardia Syndrome (POTS); Safety of IPs; Tolerability of IPs; Durability of IP treatment responses |
| NCT04841759 | The Effects of a Multi-factorial Rehabilitation Program for Healthcare Workers Suffering From Post-COVID-19 Fatigue Syndrome | COMPLETED | nan | Medical University of Vienna | Change of maximum oxygen uptake (VO2max) over time-points (baseline - 4 weeks - 8 weeks) assessed during cardio-pulmonary exercise testing (CPET) | Change of walking distance during a six minutes walk test (6MWT) over time-points (baseline - 4 weeks - 8 weeks); Change of numbers over time-points (baseline - 4 weeks - 8 weeks) how often someone can stand up and sit down on a chair within 30 seconds during |
| NCT05697640 | A Parallel-group Treatment, Phase 2a, Double-blind, Placebo-controlled 2-arm Study to Show Improvement of Physical Function in SF-36 (SF-36-PF) in Participants Treated With Vericig | ACTIVE_NOT_RECRUITING | PHASE2 | Charite University, Berlin, Germany | Improvement in Physical Function (PF) as measured by the Short Form 36 Health Survey Questionnaire (SF-36) | Difference in responder rate in Physical Function (PF) as measured by the Short Form 36 Health Survey Questionnaire (SF-36) comparing Vericiguat with placebo; Improvement in other sub-domains of the Short Form 36 Health Survey Questionnaire (SF-36) comparing V |
| NCT04751669 | Efficacy of Micronutrient Dietary Supplementation in Reducing Hospital Admissions for COVID-19: A Double-blind, Placebo-controlled, Randomized Clinical Trial | COMPLETED | nan | Fundació Institut Germans Trias i Pujol | Need for hospital admission; Incidence of Long Covid. | Micronutrient basal status (Vitamin B1, Vitamin B6, 25-OH-Vitamin D and Folic Acid; Micronutrient basal status (Vitamin B12); Micronutrient basal status (Iron, Zinc and Copper ); Micronutrient basal status (Vitamin A and Vitamin E); Micronutrient basal status |
| NCT05965739 | RECOVER-NEURO: A Platform Protocol for Evaluation of Interventions for Cognitive Dysfunction in Post-Acute Sequelae of SARS-CoV-2 Infection (PASC) | COMPLETED | nan | Duke University | Change in Everyday Cognition 2 (ECog2) | Change in PROMIS-cognitive function - short form 8a (PROMIS-Cog) total score; Change on an objective neurocognitive battery scores; Change in Everyday Cognition 2 (ECog2); Characterize the intervention's safety as measured by the proportion of Serious Adv |
| NCT06341751 | Psychological Treatment for Persistent Fatigue: a Feasibility Study | COMPLETED | nan | Karolinska Institutet | Treatment adherence and completion; Treatment credibility; Patient satisfaction; Working alliance; Negative effects of treatment; Open-ended questions regarding treatment content and presentation | Feasibility of study inclusion procedures and data-collection; Fatigue severity, primary self-rated symptom outcome; Problems concentrating; Reduced physical activity; Reduced motivation; Depressive symptoms; Somatic symptoms; General anxiety; Insomnia; Percei |
| NCT05338749 | An Open-label Trial of Computer-delivered Cognitive Training in Persons With Post-acute COVID-19 Syndrome | COMPLETED | nan | Nova Southeastern University | Technology Acceptance Model Questionnaire, Usefulness subscale | Cognitive Failures Questionnaire; Trail Making Test, Part B |
| NCT05532904 | Evaluation and Comparison of Multidisciplinary Day-hospital Versus Waiting List Management of Persistent Symptoms After an Acute Episode of COVID-19 | COMPLETED | nan | Assistance Publique - Hôpitaux de Paris | Quality of life | Quality of life; Fatigue; Dyspnea; Cognitive complaint; Pain; Patient's satisfaction; Physical fitness; Post-effort heart rate; Weight loss; BMI; Blood albumin; Nutritional risk; Health beliefs associated with persistent symptoms |
| NCT06960928 | Low Dose Sirolimus in People With Post-Acute Sequelae of COVID-19 (PASC) Long COVID-19 | RECRUITING | PHASE3 | Icahn School of Medicine at Mount Sinai | European Quality of Life-Visual Analogue Scale (EQ-VAS) | The EuroQol Five-Dimensional Health Questionnaire (EQ-5D-5L); Patient-Reported Outcomes Measurement Information System 29 (PROMIS-29); General Symptom Questionnaire (GSQ-30); Patient Health Questionnaire (PHQ-9); Generalized Anxiety Disorder (GAD-7); Neuro-QoL |
| NCT05252481 | Modulation of Post-COVID-19 Fatigue Using Transcranial Direct Current Stimulation. Transcranial Direct Stimulation for Persistent Fatigue Treatment Post-COVID-19 | COMPLETED | nan | Hospital San Carlos, Madrid | Change in Fatigue | Change in cognition; Change in depressive symptoms; Change in quality of life |
| NCT05732285 | A Pilot Randomized Controlled Trial of A Comprehensive Cognitive and Affective Intervention for Neurocognitive Disorders (CoINTEGRATE) | COMPLETED | nan | University of Michigan | Number of patients that complete the study; Average number of sessions completed; Overall experience based qualitative semi-structured interview | The Community Integration Questionnaire (CIQ) Score; The Short Form Health Survey (SF-36); Montreal Cognitive Assessment (MoCA); The Symbol Digit Modalities Test Score (SDMT-5 minutes); Brief Visuospatial Memory test (BVMT-R-25 minutes); California Verbal Lear |
| NCT05453175 | The Effect of Uninterrupted and Interrupted Sitting on Vascular Health and Cognitive Function in People with Long COVID-19 | COMPLETED | nan | University of Winchester | Pulse Wave Velocity | Central and peripheral pulse wave analysis; Cognitive function; Quality of Life - EuroQuol 5 Dimensions 5 levels (EQ-5D-5L) |
| NCT06172803 | RESToRE: Restoring Energy With Sub-symptom Threshold Optimized Rehabilitation Exercise for Long COVID | COMPLETED | nan | Columbia University | Number of participants who enrolled; Number of participants who completed; Number of participants who adhered to session attendance | PROMIS-29 scale score; Rand 36-Item Health Survey (SF-36) score; VO2 % predicted from Cardiopulmonary Exercise Testing (CPET); Number of participants with orthostatic hypocapnia.; EuroQol: Education Quotient-5D Visual Analogue Scale score; General Symptom Ques |
| NCT05954325 | Extracorporal Apheresis Hannover Medical School Study in Post COVID-19 Patients | COMPLETED | nan | Hannover Medical School | Chalder Fatigue Scale | Cognitive Function; Post exertional malaise symptoms; Measure of health status; Depression and Anxiety; Autonomic dysfunction; 6-min. walk test; Hand grip strength; Optical coherence tomography angiography; Cranial magnetic resonance imaging and spectroscopy; |
| NCT05172206 | Symptom-based Rehabilitation Compared to Usual Care in Post-COVID - a Randomized Controlled Trial | COMPLETED | nan | Schön Klinik Berchtesgadener Land | Change from baseline Quality of life assessed by Short Form - 12 Questionnaire at week 4 and week 12 | Change from baseline COVID-related symptoms at week 4 and week 12; Change from baseline lung function at week 4 and week 12; Change from baseline blood gas analysis at week 4 and week 12; Change from baseline Cardiac Doppler echocardiography at week 4 and week |
| NCT05035628 | Cardiopulmonary Rehabilitation in Long COVID-19 Patients With Persistent Breathlessness and Fatigue | COMPLETED | nan | Louis Bherer | Change in cardiorespiratory fitness | Change in 6-min walking test performance; Change in Functional mobility; Change in Lower limb muscles strength; Change in Quality-of-life; Change in Anxiety; Change in Anxiety; Change in Sleep quality; Change in functional respiratory capacity; Change in gener |
| NCT06631287 | Randomized Double-Blind Placebo-Controlled Trial EValuating Baricitinib on PERSistent NEurologic and Cardiopulmonary Symptoms of Long COVID (REVERSE-LC) | RECRUITING | PHASE3 | Wes Ely | CNS-Vital Signs Global Cognitive Index | Objective neuropsychological function domains of executive function, memory, processing speed, and motor speed including the CNS-Vital Signs subscale tests at 6-months.; Objective neuropsychological function domains of executive function, memory, processing sp |
| NCT05658536 | The COPE Study: Pilot Intervention to Improve Symptom Self-management and Coping in Adults With Post COVID | COMPLETED | nan | University of Washington | Intervention Acceptability; Intervention Appropriateness; Intervention Feasibility | Depressive Symptoms; Anxiety Symptoms; Fatigue; Sleep Disturbance; Perceived Cognitive Difficulties; Self-Efficacy; Psychosocial Functioning; Pain Interference; Impression of Change; Symptoms and Impact of Post-COVID |
| NCT06847191 | A Double-blind, Randomized Study to Evaluate the Efficacy and Safety of Bezisterim (NE3107) in Adults With Long COVID | ACTIVE_NOT_RECRUITING | PHASE2 | BioVie Inc. | Change from Baseline in performance on the Cogstate Cognition battery* | Change from Baseline in PROMIS Cognitive Function Short Form 8a (SF-8a); Change from Baseline in PROMIS Fatigue Short Form 13a (SF-13a); Change from Baseline in PROMIS Sleep Disturbance Short Form 8a (SF-8a); Change from Baseline in SF-12 Health Survey (Physic |
| NCT05752331 | Feasibility of Personalised Health Behaviour Coaching to Support Symptoms and Activities of Daily Living in Those With Long COVID-19. | COMPLETED | nan | Bournemouth University | Participant recruitment; Participant randomisation; Participant completion; Participant acceptability | Objective physical activity; Exercise capacity; Muscular strength and endurance; Lung Function; Health related quality of life; Breathlessness; Fatigue; Anxiety and Depression; Cognitive impairment |
| NCT05298878 | Virtual Physical Rehabilitation for Patients Living with Long COVID | COMPLETED | nan | McGill University Health Centre/Research Institute of the McGill University Health Centre | Change in the basic mobility domain of the Activity Measure for Post-Acute Care (AM-PAC) | Change in lower-body strength; Change in functional mobility; Change in fatigue; Change in dyspnea; Change in health-related quality of life; Change in health state utilities; Change in anxiety and depression; Change in cognitive function; Change in the degree |
| NCT05690503 | Glutamatergic Modulation as a Treatment for Depressive Symptoms Among Patients With Post-acute Sequelae of COVID (PASC): A Pilot Trial | ACTIVE_NOT_RECRUITING | PHASE2 | New York State Psychiatric Institute | Reduction in depressive symptoms | Improvement in neurocognitive symptoms of PASC |
| NCT06296914 | Developing and Testing a Mobile Health System for Patients with Postural Orthostatic Tachycardia Syndrome (POTS) | COMPLETED | nan | Jami Warren | Change in POTSapp Usability as measured by uMARS; Change in POTSapp Usage - number of page views; Change in POTSapp Usage - time spent in app; Change in POTSapp Usability as measured by Health-ITUES; Change in POTSapp Effectiveness as measured by Message Effec | Change in Participant Quality of Life; Change in Doctor Patient Communication (DPC); Adapted IBS Perceived Stigma Scale; Cognitive Learning |
| NCT04797871 | Resistance Training Intervention on the Clinical Status in Patients With Post Discharge Symptoms After Covid-19: The "EXER-COVID Study" | COMPLETED | nan | Universidad Pública de Navarra | Changes in Cardiorespiratory fitness | Changes in Post-COVID manifestations; Changes in Blood samples analysed for markers related to low grade inflammation; Changes in pulse wave velocity; Changes in cardio-ankle vascular index (CAVI); Changes in Energy expenditure; Changes in bone mineral density |
| NCT07359482 | sElective Serotonin reuPtake inhibitoRs In posT-covid: ESPRIT | NOT_YET_RECRUITING | PHASE3 | Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) | Fatigue severity | Fatigue severity; Cognitive functioning; Cognitive functioning; PEM; POTS (National Aeronautics and Space Administration (NASA) lean test; POTS; Health-related Quality of Life; Disability; Side effects; Side effects; Brain Perfusion (optional MRI substudy); Br |
| NCT06391489 | Piloting A Telehealth Deliverable Self-Management and Cognitive Training Program (HOBSCOTCH, HOme Based Self-Management and COgnitive Training CHanges Lives) for People With Post A | ACTIVE_NOT_RECRUITING | nan | Dartmouth-Hitchcock Medical Center | Change in overall quality of life as measured by comparing PROMIS-10 Global Health scores pre- and post-HOBSCOTCH-PACS intervention.; Change in subjective cognition as measured by comparing Neuro-QOL Item Bank v2.0 Cognitive Function scores pre- and post-HOBSC | Change in objective cognition as measured by comparing Symbol-Digit Modalities Test scores pre- and post-HOBSCOTCH-PACS intervention.; Change in objective cognition as measured by comparing California Verbal Learning Test-III scores pre- and post-HOBSCOTCH-PAC |
| NCT05705193 | Computerized Cognitive Remediation of Long COVID Symptoms in Older Adults | ACTIVE_NOT_RECRUITING | nan | UConn Health | Treatment Acceptability/Adherence Scale (TAAS); Credibility/Expectancy Questionnaire (CEQ); System Usability Scale (SUS); Feasibility (proportion of subjects who agree to participate in the offered treatment, complete assigned exercises, and complete the entir | Trail Making Test Part B; Montgomery-Asberg Depression Scale (MADRS); World Health Organization Disability Assessment Schedule (WHODAS); Everyday Cognition (ECog); Verbal Fluency; Stroop Color and Word Test; Fatigue Assessment Scale (FAS); California Verbal Le |
| NCT07254377 | START: Design and Validation of Innovative Strategies Based on Dual-Task Approach for Neuro- Rehabilitation Technologically-supported in People With Chronic Neuro-inflammatory Dise | ACTIVE_NOT_RECRUITING | nan | I.R.C.C.S. Fondazione Santa Lucia | 6-Minute Walking Test | Montreal Cognitive Assessment |
| NCT06511050 | Investigating the Effects of Lumbrokinase in Adults With Long Covid, Post-treatment Lyme Disease Syndrome, and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome | RECRUITING | PHASE1; PHASE2 | Icahn School of Medicine at Mount Sinai | EuroQol Visual Analogue Scale Score (EQ-VAS) | The EuroQol Five-Dimensional Health Questionnaire (EQ-5D-5L); 10-Meter Walk Test; Root mean square of successive differences between normal heartbeats (RMSSD); BrainCheck Cognitive Assessment Battery; General Symptom Questionnaire (GSQ-30); Medical Research Co |
| NCT06974084 | A Multi-Center Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy of Maraviroc and Atorvastatin for the Treatment of Subjects With Long COVID/Post-Acute Se | NOT_YET_RECRUITING | PHASE2; PHASE3 | HealthBio, Inc. | Fatigue | Improvement in dysautonomia symptoms as reflected by the Composite Autonomic Symptom Score (COMPASS-31); Improvement in Dyspnea; Improved Cognitive Function, measured by the PROMIS (Patient-Reported Outcomes Measurement Information System) Cognitive Function v |
| NCT05731570 | Cognitive Impairment in Long Covid: PhEnotyping and RehabilitatiOn (CICERO) | ACTIVE_NOT_RECRUITING | nan | University College, London | Change in Goal-attainment | Change in cognitive function; Change in quality of life (EQ-5D-5L); Change in Life Space Questionnaire; Social Functioning (SF-DEM); Change in Instrumental Activities of Daily Living (IADL) Scale; Generalised Anxiety Disorder Assessment (GAD-7); Change in Pati |
| NCT06511063 | Investigating the Feasibility of Repurposing HIV Antivirals in Adults With Long Covid | RECRUITING | PHASE2 | Icahn School of Medicine at Mount Sinai | EuroQol 5-Dimension 5-Level (EQ-5D-5L) Visual Analogue Scale | The EuroQol Five-Dimensional Health Questionnaire (EQ-5D-5L); Patient-Reported Outcomes Measurement Information System 29 (PROMIS-29); General Symptom Questionnaire (GSQ-30); Patient Health Questionnaire (PHQ-9); Generalized Anxiety Disorder (GAD-7); Neuro-QoL |
| NCT07298005 | SON4PEM Study: Sonlicromanol in Post-COVID: A Randomized, Double-blind, Placebo-controlled, Phase II Trial | RECRUITING | PHASE2 | Michele van Vugt | Fatigue | Muscle strength; Cognitive function; Health related quality of life; Fatigue |
| NCT06231238 | A Randomised Controlled Trial Assessing the Efficacy of Balance Acceptance and Commitment Therapy (ACT) for Long COVID. | ACTIVE_NOT_RECRUITING | nan | King's College London | Physical Component Summary (PCS) of the 36-item Short Form Health Survey (SF-36) at Week 14 | EuroQol 5 Dimension - 5 Levels (EQ-5D-5L); Adult Service Use Schedule; Functional Assessment of Chronic Illness Therapy - Fatigue (FACIT-F); Modified Clinical Global Impressions Scale- Improvement (CGI-I); Pittsburgh Sleep Quality Index (PSQI); Modified Patien |
| NCT07316127 | A Placebo-Controlled, Double-Blind, Randomized Trial Phase I-II With Immunoadsorption in Autoimmune Long COVID | RECRUITING | PHASE2 | Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) | Change in fatigue measured by the Fatigue Assessment Scale (FAS) | Change in health related quality of life using the 36-Item Short Form Health Survey (SF-36); Change in cognitive functioning using the Patient-Reported Outcomes Measurement Information System (PROMIS®) Cognitive Function Short Form 8a (PROMIS Cognitive Functio |
| NCT06586398 | A Pilot Randomized Trial of rTMS for Fatigue and Brain Fog and Neuropsychiatric Symptoms of Long-COVID. | ACTIVE_NOT_RECRUITING | nan | University of California, Los Angeles | Tolerability as measured by Safteesi survey; Safety profile and adverse events | Subjective Cognitive impairment assessed by Multidimensional Inventory of Subjective Cognitive Impairment (MISCI); Fatigue assessed by Fatigue Severity Scale (FSS); Physical and mental health assessed by PROMIS-29; Alzheimer's Disease Assessment Scale (AD |
| NCT06124625 | Effects of Rehabilitation Combined With a 12-week Maintenance Program Compared to Rehabilitation Alone in Post-COVID-19 - a Randomized, Controlled Trial. | ACTIVE_NOT_RECRUITING | nan | Schön Klinik Berchtesgadener Land | Change from baseline quality of life assessed by Short-Form 12 questionnaire at week 4 and week 19 | Change from baseline post-COVID-related symptoms at week 4 and week 19; Change from baseline lung function at week 4 and week 19; Change from baseline fatigue symptoms at week 4 and week 19; Change from baseline exercise capacity at week 4 and week 19; Change |
| NCT04935307 | Central Processing of Odour Stimuli in Patients With Multi-systemic Functional Somatic Disorder, Multiple Chemical Sensitivityor Post Covid Compared to Healthy Controls - the Pilot | ACTIVE_NOT_RECRUITING | nan | University of Aarhus | "Fingerprinting"; "Sniffing Stick test" | Pain thresholds; Heart Rate Variability; Cognitive testing |
| NCT06012552 | Randomized, Double-blind, Placebo-controlled Trial of the Efficacy and Safety of Tianeptine in the Treatment of Covid Fog Symptoms in Patients After COVID-19 With the Study of the | RECRUITING | PHASE2 | Military Institute od Medicine National Research Institute | Improvement in covid fog symptoms | improving cognitive function; Change in brain metabolic activity |
| NCT05167227 | The Long COVID and Fatiguing Illness Recovery Program - A Pragmatic, Quality Improvement, Professional Cluster, Randomized Controlled Trial. | ACTIVE_NOT_RECRUITING | nan | Family Health Centers of San Diego | Patient-Reported Outcomes Measurement Information System (PROMIS)-29 | Patient symptom checklist with associated severity for those present; If symptom is present, has patient experienced this in the past month; If symptom is present, how long has patient experienced this symptom; If symptom is present, did patient have this symp |
| NCT05764538 | DAOIB for the Treatment of Cognitive Impairment Induced by COVID-19 -An Open Trial | RECRUITING | PHASE2 | Chang Gung Memorial Hospital | Change from baseline in the Alzheimer's disease assessment scale - cognitive subscale at week 8, 16 and 24 | Change from baseline in Clinician's Interview-Based Impression of Change plus Caregiver Input score at week 8, 16 and 24; Change from baseline in Alzheimer's disease Cooperative Study scale for ADL in MCI (ADCS-MCI-ADL) score at week 8, 16 and 24; Ch |
| NCT07021794 | Effectiveness of Treating Post-COVID-19 Conditions (Long COVID) With the SARS-CoV-2 Specific Monoclonal Antibody, Sipavibart | RECRUITING | PHASE2 | Nancy Klimas | Patient-Reported Outcomes Measurement Information System-29; Review of Treatment Related Adverse Events | Symptom-specific participant-reported outcome measures; Change in Simple Reaction Time (Milliseconds); Self-reported fatigue using MFI; Change in Heart Rate Post-6MWT; Processing Speed; Attention; Systolic Blood Pressure Response During NASA Lean Test; Diastol |
| NCT06560554 | Evaluating the Effects of a Fermented Diet on Microbiome Diversity in Individuals With Long COVID | ENROLLING_BY_INVITATION | nan | Mayo Clinic | Gut Microbiome diversity | Symptoms of depression and anxiety; Assessment of cognition; Assessment of quality of life; Assessment of post-traumatic stress (PTSD) symptoms |
| NCT06928480 | Effectiveness and Acceptability of the Unified Protocol for the Transdiagnostic Treatment of Emotional Disorders in People With Long COVID-19. | RECRUITING | nan | Instituto de Investigación Sanitaria Aragón | General Depression Severity and Interference Scale (ODSIS; Bentley et al., 2014. Validated in Spanish by Osma et al., 2019); General Severity and Interference Scale for Anxiety (OASIS; Norman et al., 2006. Validated in Spanish by Osma et al., 2019) | Memory Failures of Everyday, MFE (Sunderland et al., 1983; Montejo et al., 2014); Multidimensional Inventory for Emotional Disorders (MEDI; Rosellini and Brown, 2019. Validated in Spanish by Osma et al., 2023); Emotional Regulation Difficulties Scale (DERS; Gr |
| NCT06142253 | Water-based Activity to Enhance Recovery in Long COVID | RECRUITING | nan | VA Office of Research and Development | Feasibility of Intervention Measure | Acceptability of Intervention Measure; Change in Fatigue Severity Scale; Change in Mental Fatigue Scale; Change in Digit Span; Change in Digit Symbol Substitution Test; Change in Stroop Color Word Test; Change in Rey Auditory Verbal Learning Test; Change in NI |
| NCT07197138 | Pilot Study on the Effects of Intensified Repetitive Transcranial Magnetic Stimulation on Immunological Blood Parameters in Patients With Depression and Comorbid Post-COVID-19 Cond | RECRUITING | nan | Max-Planck-Institute of Psychiatry | Change in immunophenotypic marker CRP from baseline to post-treatment; Change in immunophenotypic marker TNF from baseline to post-treatment; Change in immunophenotypic marker IL-1ß from baseline to post-treatment; Change in immunophenotypic marker IL-6 from b | Change in Fatigue Severity Scale (FSS, self-rating); Change in Fatigue Scale for Motor and Cognitive Functions (FSMC, self-rating); Change in Post-Exertional Malaise (PEM) Questionnaire (self-rating); Change in Pittsburgh Sleep Quality Index (PSQI, self-rating |
| NCT06178952 | Transcranial Pulse Stimulation (TPS) in Post-COVID-19 | RECRUITING | nan | Medical University of Vienna | Fatigue Impact Scale (FIS) | Beck Depression Inventory (BDI-II); Montreal Cognitive Assessment (MOCA); 36-Item Short Form Health Survey (SF-36); Trail Making Test A and B (TMT-A and TMT-B); Positive and Negative Affect Schedule (PANAS); Beck Anxiety Inventory (BAI); Six Minute Walking Tes |
| NCT06614309 | Pilot Study to Investigate Possible Non-invasive Treatment for Long COVID (Post COVID-19 Condition) Brain Fog | RECRUITING | nan | Mayo Clinic | Change in cerebral blood flow; Change in heart rate variability; Change in brain fog scale | Change in fatigue functional assessment of chronic illness therapy-fatigue scale; Change in short form health survey (SF-36); Change in Trail making test; Change in rapid cognitive assessment tool (RCAT) score; Change in Task switching test performance; Change |
| NCT07089719 | Bevacizumab in Post-acute Sequelae of COVID-19 : Efficacy and Safety (Pilot Study) | NOT_YET_RECRUITING | PHASE2 | Assistance Publique - Hôpitaux de Paris | Rate of patients with 10% increase of impaired DLCO | Proportion of patients with recovery of clinical symptoms; Proportion of patients with recovery of psychological, cognitive, and autonomic functions; Proportion of patients with improvement of other parameter than DLCO explored by Pulmonary Function Test; Modi |
| NCT06928506 | RECLAIM: Recovering From COVID-19 Lingering Symptoms Adaptive Integrative Medicine Trial - Effect of Hi-OxSR for the Treatment of Post COVID Condition (RECLAIM-HiOxSR) | RECRUITING | nan | University Health Network, Toronto | Simple reaction time (SRT) task from the TestMyBrain (TMB) Digital Neuropsychology Toolkit On-line survey tool; Verbal paired associates (VPA) task from the TestMyBrain (TMB) Digital Neuropsychology Toolkit On-line survey tool | All cognitive performance tasks (measured by the TESTMYBRAIN.org (TMB) neuropsychology toolkit; Brain Fog Questionnaire; Brief Fatigue Inventory; Short Form (SF)-36; Safety, adverse events and serious adverse events; Symptom Checklist; The DePaul Symptom Post- |
| NCT05705648 | Nutritional Management of Post COVID-19 Cognitive Symptoms | RECRUITING | nan | University of Alberta | Cognigram(R) | Montreal Cognitive Assessment |
| NCT06086379 | Cognitive Rehabilitation to Improve Functioning in Veterans Following COVID-19 | ENROLLING_BY_INVITATION | nan | VA Office of Research and Development | Change in World Health Organization - Disability Assessment Schedule (WHODAS 2.0) | Change in objective cognitive performance z score; Change in functional capacity performance z score; Change in Patient Health Questionnaire 9 (PHQ-9); Change in Generalized Anxiety Disorder 7 (GAD-7); Change in PTSD Checklist for DSM-5 (PCL-5); Change in Cogn |
| NCT06452095 | RECLAIM: Recovering From COVID-19 Lingering Symptoms Adaptive Integrative Medicine Trial - Effect of Hyperbaric Oxygen Therapy for the Treatment of Post COVID Condition (RECLAIM-HB | RECRUITING | nan | University Health Network, Toronto | Simple reaction time [SRT] task from the TestMyBrain (TMB) Digital Neuropsychology Toolkit; Verbal paired associates [VPA] task from the TestMyBrain (TMB) Digital Neuropsychology Toolkit | Symptoms scale; Symptom Checklist; Six Minute Walking Test (6MWT) with oximetry; SF-36; TestMyBrain cognitive testing; Post COVID19 functional status scale; Reintegration to Normal Living Index (RNLI); The Fatigue Scale; Brief Fatigue inventory; Post-Exertiona |
| NCT06045338 | Mind Body Intervention for Long COVID | RECRUITING | nan | Beth Israel Deaconess Medical Center | Somatic Symptom Score-8 (SSS-8) | Short Form Brief Pain Inventory (BPI); Fatigue Severity Scale (FSS); The Multidimensional Dyspnea Profile (MDP); Generalized Anxiety Disorder form 7 (GAD-7); Patient Reported Outcomes Measurement Information System survey for function disability (PROMIS); End |
| NCT07278206 | Mitigating Cognitive Problems and Fatigue With Brain Stimulation in Long COVID | RECRUITING | nan | Amsterdam UMC, location VUmc | Fatigue | Objective cognitive functioning; Arterial Spin Labeling (ASL); Magnetic Resonance Spectroscopy (MRS); Functional Magnetic Resonance Imaging (fMRI); Actigraphy; Short physical performance battery (SPPB); Simple Reaction Time (SRT); Effort-based decision task; N |
| NCT06915324 | Transcranial Direct Current Stimulation (tDCS) of Brain Fog in Patients With Post Treatment Lyme Disease | RECRUITING | nan | Columbia University | Coding test scale score for acute treatment; Coding test scale score for post-treatment follow-up | Composite score of the reaction time measures; Fatigue Severity Scale (FSS) Score; General Symptom Questionnaire (GSQ-30) Score; Generalized Anxiety Disorder-7 (GAD-7) Score; PROMIS Emotional Distress-Depression-Short Form Score; Patient-Reported Outcomes Meas |
| NCT06292377 | Better Understanding of Fatigue After STroke | RECRUITING | nan | Brugmann University Hospital | Heart rate variability (HRV); Heart rate variability (HRV); Heart rate variability (HRV); Transthoracic echography (TTE); Transthoracic echography (TTE); Transthoracic echography (TTE); Fatigue Severity Scale (FSS-7); Fatigue Severity Scale (FSS-7); N-terminal | Blood CRP level; Blood neutrophil-to-lymphocyte ratio (NLR); Stroke localization in the brain; Fazekas scale; Global cortical atrophy scale; Informant Questionnaire on Cognitive Decline in the Elderly (IQCODE); Presence for pre-existing fatigue (yes/no); Durat |
| NCT05851859 | Randomized Controlled Trial Evaluating the Effectiveness of a Breathing Control Technique on Long COVID Symptoms at the Reunion University Hospital | RECRUITING | nan | Centre Hospitalier Universitaire de la Réunion | Evaluation of the effectiveness of a respiratory training to cardiac coherence on the reduction in the symptomatology of patients with Long COVID. | Evaluation of the effectiveness of a respiratory training to cardiac coherence on the decrease of overall symptoms over time; Evaluation of the effectiveness of a respiratory training to cardiac coherence on the decrease of specifics symptoms : fatigue; Evalua |
| NCT06871293 | Impact of Functional and Cognitive Rehabilitation, in Adults With Chronic Noncommunicable Diseases and Long Covid-19 , on Their Functional and Cognitive Capacity, Quality of Life, | RECRUITING | nan | Fundación Cardioinfantil Instituto de Cardiología | Composite Change in Functional Capacity, Cognitive Function, Health-Related Quality of Life, and Strength | Change in Functional Capacity; Change in Cognitive Function; Change in Health-Related Quality of Life; Change in Health-Related Quality of Life, Visual Analogue Scale; Change in Handgrip Strength, Hydraulic Dynamometer; Incidence of Chronic Disease Decompensat |
| NCT06292741 | Evaluation of the Prevalence of Autonomic Nervous System Involvement in Patients With Cognitive Impairment by a Non-invasive Combined Study of Dysautonomia | RECRUITING | nan | Fondazione Policlinico Universitario Agostino Gemelli IRCCS | evaluation of the prevalence in autonomic dysfunction in patients with MCI and dementia | correlation between the extent of autonomic involvement and the severity of cognitive decline; evaluation of the type of cognitive disorder, defined by the scores obtained in the MMSE between subjects with and without autonomic dysfunction. |
| NCT05858515 | REVERSE-Long COVID: A Multicenter Randomized, Placebo-Controlled Clinical Trial of Immunomodulation (With Baricitinib) for Long COVID Related Cognitive Impairment and ADRD (Alzheim | WITHDRAWN | PHASE3 | Vanderbilt University Medical Center | Enrollment; Diversity in enrollment; Study drug prescribed; Study withdrawals; Adverse event reporting; Study dosing; Study completion | Severe and Serious Adverse Events; Premature study discontinuation; Global Neuropsychological Function; Cardiopulmonary testing; Everyday Cognition; Functional Status; Quality of Life Measures; Post-Exertional Malaise; Shortness of Breath; Symptom Burden; Infl |
| NCT05914649 | Neurocognitive Testing in Long COVID and Postural Tachycardia Syndrome Patients With Normal Saline: A Pilot Study | RECRUITING | nan | University of Calgary | 5RTI Reaction Time task (Standing) | Reaction Time Test (Psychomotor Speed); Paired Associates Learning (Visual Episodic Memory); Verbal Recognition Memory (Verbal memory); Multitasking Test (Executive Function - Inhibition) |
| NCT05931497 | A Pilot Study of Whole Body Hyperthermia for Long Covid or Post-Acute Sequelae of COVID-19 (PASC) | RECRUITING | nan | Massachusetts General Hospital | The Patient Reported Outcome Measurement Information System Fatigue-Short Form v1.0 -Fatigue 7a (PROMIS F-SF) | Patient-Reported Outcomes Measurement Information System (PROMIS-29); Patient Health Questionnaire-9 (PHQ); The Perceived Stress Scale (PSS); Patient-Reported Outcomes Measurement Information System Cognitive Abilities; Patient-Reported Outcomes Measurement In |
| NCT07597902 | SARS-CoV-2 and Herpesvirus Inhibition for Ending Long COVID Dysfunction (SHIELD) | NOT_YET_RECRUITING | PHASE2 | Icahn School of Medicine at Mount Sinai | EQ-5D-5L Visual Analogue Scale (VAS) | The EuroQol Five-Dimensional Health Questionnaire (EQ-5D-5L); Patient-Reported Outcomes Measurement Information System 29 (PROMIS-29); General Symptom Questionnaire (GSQ-30); Patient Health Questionnaire (PHQ-9); Generalized Anxiety Disorder (GAD-7); COLUMBIA- |
| NCT05986422 | Phase 2a, Double-blind, Randomized, Placebo-controlled Trial of Methylprednisolone Versus Placebo in Patients With Cognitive Deficits in Post-COVID-19 Syndrome (PCS) | TERMINATED | PHASE2 | Charite University, Berlin, Germany | Improvement in memory satisfaction as measured by the Multifactorial Memory Questionnaire (MMQ) | Long-term improvement in memory satisfaction as measured by the Multifactorial Memory Questionnaire (MMQ); Improvement in memory ability and memory strategy as measured by the Multifactorial Memory Questionnaire; Improvement in neurocognitive functions as meas |
| NCT07600320 | Microtesla Magnetic Therapy (MMT) Treatment of Cognitive Impairment: Open Label Pilot Study | NOT_YET_RECRUITING | nan | Icahn School of Medicine at Mount Sinai | Proportion of participants who complete prescribed device sessions | BrainCheck; Hospital Anxiety and Depression Scale (HADS); PROMIS Sleep Disturbance; Neuro-QoL Cognitive Function (Short Form); PROMIS Fatigue; Patient Global Impression of Change (PGIC); Functional Capacity Assessment (FUNCAP) |
| NCT05274477 | Randomized Placebo-controlled Phase II Cross-over Study on the Influence of Fampridine on Working Memory in Individuals With Post COVID-19 Condition With Subjective Cognitive Impai | TERMINATED | nan | Prof. Dominique de Quervain, MD | Digits Span backward performance | Digits Span forward performance; Red Button Task; Symbol Digit Modalities Test, SDMT; Verbal episodic memory performance (word list); Lexical ability; Bochumer Matrizentest (BOMAT - standard); Subjective cognitive impairment; Resting motor threshold (rMT) |
| NCT07530757 | Randomized Controlled Trial to Assess the Efficacy of a Supervised Computerized Active Program (SuperCAP) to Improve Cognition and Daily Functioning in People With Post-COVID-19 Co | NOT_YET_RECRUITING | nan | Fundación FLS de Lucha Contra el Sida, las Enfermedades Infecciosas y la Promoción de la Salud y la Ciencia | To determine whether the SuperCAP intervention program is superior to control in reducing disability. | To assess whether the SuperCAP intervention leads to greater improvements in quality of life compared with control.; To assess whether the SuperCAP intervention leads to greater improvements in instrumental daily functioning compared with control.; To evaluate |
| NCT05582603 | Detailed Study on the Safety, Dosage and Feasibility of an Intervention Based on a Computerized Cognitive Training (CCT) for Individuals With Post-acute Sequelae of COVID-19 (PASC) | UNKNOWN | PHASE1; PHASE2 | Universidad Antonio de Nebrija | Fatigue Level Questionnaire; Fatigue Level Questionnaire; Safety Level Questionnaire; Safety Level Questionnaire; Classification of side effect or adverse events; Classification of side effect or adverse events | Computerized Cognitive Assessment; Quality of Life Assessment; Paper-and-pencil Cognitive Assessment |
| NCT06953661 | Ultrasound Guided Stellate Ganglion Block in Postural Tachycardia Syndrome: A Randomized Double Blind Sham Placebo-controlled Pilot Study | NOT_YET_RECRUITING | nan | Stanford University | COMPASS 31 total score | Magnitude of postural tachycardia; Heart rate variability (HRV); Plasma catecholamine levels; Survey of Postural Orthostatic Tachycardia Syndrome Symptoms (SPOTS); VOSS score; FSS score; PROMIS Cognitive Function Short Form 6a; EQ-5D score; PGI-S rating; PGI-C |
| NCT06534164 | Telerehabilitation of Balance Clinical and Economic Decision Support System | NOT_YET_RECRUITING | nan | University College, London | Recruitment Rate (acceptability); Incidence of Treatment-Emergent Adverse Events (safety); Feasibility (protocol deviations/problems); Participants experience using the system (usability); Adherence to Intervention; Drop-out rate (acceptability) | Mini Balance Evaluation Systems Test (Mini-BESTest); Functional Gait Assessment (FGA); Incremental cost-effectiveness ratio (ICER); EuroQol five dimensional descriptive system (EQ-5D-5L); Montreal Cognitive Assessment (MoCA); Rapid Assessment of Physical Activ |
| NCT ID | Title | Status | Phase | Sponsor | Primary endpoint | Secondary endpoint |
|---|---|---|---|---|---|---|
| NCT05212610 | Assessing Safety of COVID-19 mRNA Vaccine Administration in the Setting of a Previous Adverse Reaction | COMPLETED | PHASE4 | University of Michigan | Participants Who Had a Reaction to an Initial or Additional Dose of the Pfizer-BioNTech or Moderna COVID-19 mRNA Vaccine, or Who Had Long COVID; Number of Participants With Treatment-related Allergic Reaction Adverse Events | Number of Non-allergic Clinical Adverse Reactions |
| NCT04977388 | Phase I/II Study of NORTHERA (DROXIDOPA) for Dysautonomia in Adult Survivors of Menkes Disease and Adults With Occipital Horn Syndrome: Double-blind Placebo-controlled Randomized C | COMPLETED | PHASE1; PHASE2 | Stephen G. Kaler, MD | Treatment Related Adverse Events as Assessed by CTCAE v4.0 | Mean Change in Systolic Blood Pressure in Tilt Position; Mean Change in Diastolic Blood Pressure in Tilt Position; Plasma Catechol Levels; Change From Baseline in Daily Bowel Movements; Change From Baseline in Time Standing Duration; Change From Baseline in Ti |
| NCT03356821 | Adult Mesenchymal Stromal Cells to Regenerate the Neonatal Brain: the PASSIoN Trial (Perinatal Arterial Stroke Treated With Stromal Cells IntraNasally) | COMPLETED | PHASE1; PHASE2 | UMC Utrecht | Number of Participants With Adverse Events Related to Intranasal MSC Treatment (Safety and Tolerability) in the Acute Setting. | Number of Participants With Adverse Events Related to Intranasal MSC Treatment (Safety and Tolerability) in the Subacute/Long-term Setting |
| NCT04880161 | A Randomized, Double-Blinded, Placebo-Controlled Phase I Study to Evaluate the Safety and Efficacy of Ampion in Patients With Prolonged Respiratory Symptoms Due to COVID-19 (Long C | COMPLETED | PHASE1 | Ampio Pharmaceuticals. Inc. | The Number of Participants With Treatment Emergent Adverse Events of Ampion Compared to Placebo | nan |
| NCT04997395 | Safety and Tolerability of Full Spectrum Cannabidiol Dominant Medicinal Cannabis in Treating Symptoms Associated With Long COVID: A Feasibility Study | COMPLETED | PHASE2 | Bod Australia | Recruitment rate; Tolerability for the treatment of long COVID; Number of side effects | Long COVID symptoms; Fatigue; Self-reported quality of life; Pain score; Mood (anxiety); Mood (depression); Sleep quality; Resting heart rate (expressed as average beats per minute); Activity levels (number of daily steps, distance walked, stairs climbed, acti |
| NCT05682560 | A Randomized Controlled Phase IIa, Two-arm Study to Assess the Safety and Efficacy of Human Umbilical Cord Blood (RegeneCyte) Infusion in Patients with Post-COVID Syndrome | COMPLETED | PHASE2 | StemCyte, Inc. | Treatment-emergent adverse events (TEAEs) | Change of fatigue score as measured by CFQ-11 |
| NCT05228899 | A Phase I/II Multicenter, Randomized, Double Blinded, Placebo Trial to Evaluate the Safety and Potential Efficacy of Zofin Infused Intravenous (IV) in Patients Experiencing Prolong | COMPLETED | PHASE1; PHASE2 | ZEO ScientifiX, Inc. | Incidence of Severe Adverse Events | Fatigue Severity Score Score; Daily Diary of COVID-19 Related Symptom; COVID-19 Associated Symptoms Length; COVID-19 Associated Symptoms Mitigation; Beck Depression Inventory Score; Mental Fatigue Questionnaire Score; Pulse Oxygen Saturation; Heart Rate Variab |
| NCT05445674 | Plasma Exchange Therapy for Post- COVID-19 Condition: A Pilot, Randomized Double-Blind Study | COMPLETED | PHASE2 | Fundación FLS de Lucha Contra el Sida, las Enfermedades Infecciosas y la Promoción de la Salud y la Ciencia | Evaluate the safety and tolerability of PE in patients with Post-Acute Covid-19 Syndrome (PCC) comparing to sham plasma exchange (placebo); Proportion of subjects with Grade 0, 1 o 2 functional disability assessed by the functional status scale (PCFS); Proport | Assess the ability of PE to improve PCC symptoms; Assess the impact of PE on quality of life in subjects with PCC; Assess the impact of PE on quality of life in subjects with PCC using MOS-HIV questionnaire; Assess the impact of PE on neurocognitive symptoms i |
| NCT06223971 | A Phase l Study to Assess the Safety and Tolerability of PET Imaging With [11 C]CPPC [5-cyano-N-( 4-( 4-[l l CJ me1hylpiperazin-l-yl)-2-(Piperidin-l-yl)Phenyl)Furan-2-carboxamide] | COMPLETED | EARLY_PHASE1 | Johns Hopkins University | To assess the safety and tolerability of one dose level of [11C]CPPC when administered intravenously.; Safety of use of [11C]CPPC in patients with Long-COVID and healthy participants with history of COVID-19 infection as assessed by a change in complete blood | Biodistribution of [11C]CPPC by PET imaging; Cognitive function as assessed by the NIH Toolbox Cognition Battery (NIHTB-CB); Neuro-psychological assessment as assessed by the The Rey-Osterrieth complex figure test (ROCF); Global cognitive function as assessed |
| NCT06204432 | Efficacy of Adjunctive Sodium Citrate in Smell Retraining for People With Post-Acute Sequelae COVID-19 Olfactory Dysfunction | ACTIVE_NOT_RECRUITING | PHASE2 | University of North Carolina, Chapel Hill | The Number of Eligible Patients; The Proportion of Participants Who Were Enrolled in the Study; The Proportion of Participants Who Complete the Study; Proportion of Participants Who Report Minor or Severe Adverse Events; Adherence Rate Distribution | Change in Sniffin' Sticks Score |
| NCT05836402 | Low-Carbohydrate Dietary and Lifestyle Interventions for the Management of Long COVID-19 Syndrome: A Prospective and Interventional Randomized Controlled Pilot Study | COMPLETED | nan | University of Southern California | Feasibility of dietary intervention:; Safety signals for electrolytes; Safety signals for kidney function; Safety signals for liver function; Cardiovascular risk; Improved uric acid metabolism; kidney function: proteinuria; Safety and tolerability of dietary i | Improvement of long-COVID syndrome signs Measurement of change in body weight; Improvement of long-COVID syndrome signs Measurement of aerobic capacity:; Improvement of long-COVID syndrome signs: Measures of inflammation; Improvement of long-COVID syndrome sig |
| NCT05793736 | A Feasibility Study of an HVR Protocol Biofeedback Training to Manage Long Covid Syndrome Symptoms | COMPLETED | nan | University of Cagliari | Change from Baseline to 5 weeks and to 9 weeks in Patient Health Questionnaire-9 (PHQ-9) score; Change from Baseline to 5 weeks and to 9 weeks in Brief Fatigue Inventory (BFI) score; Change from Baseline to 5 weeks and to 9 weeks in Short Form Health Survey (S | nan |
| NCT05003271 | Pulmonary Rehabilitation Post-COVID-19: a Pilot Study | COMPLETED | nan | University of Manitoba | Feasibility of the program; Recruitment rate; Intervention completion rate; Dropout rate; Patient safety; Patient satisfaction with the program | Change in lung capacity; Change in dyspnea; Changes in fatigue severity assessed with the Fatigue Severity Scale; Changes in fatigue assesses with the DePaul Symptom Questionnaire short-form; Change in sit-to-stand capacity; Change in post-exercise saturation; |
| NCT06379620 | Pilot Open Label Use of the Hi-OXSR to Increase PaCO2 for the Treatment of Post COVID-19 Cognitive Dysfunction | COMPLETED | PHASE1 | University Health Network, Toronto | Safety of use of Hi-OX sequential rebreathing device | nan |
| NCT05747534 | Phase 2a Randomized, Double-Blind, Placebo-Controlled, Multi-Center Study to Evaluate the Safety and Efficacy of Larazotide (AT1001) for the Treatment of Long COVID in Children and | ACTIVE_NOT_RECRUITING | PHASE2 | Massachusetts General Hospital | Adverse Event Profiling and Time to Symptom Resolution | Cytokine profiling, Antigen Testing and Humoral and Cellular Responses |
| NCT05074771 | RIabilitazione di Pazienti COvid e Loro Monitoraggio IN Casa Con la pIattaforma ARc-IntEllicare - (RICOMINCIARE) | COMPLETED | nan | Camlin Ltd | Adherence Rate; Device-related adverse events; Attrition rate | System Usability Scale (SUS); Patient Satisfaction; Resource consumption |
| NCT05219929 | T4 - Tetracycline Treatment Tolerability Trial A Pilot Study Examining the Feasibility and Tolerability of Tetracycline Therapy in Post-Treatment Lyme Disease (PTLD) | ENROLLING_BY_INVITATION | PHASE2 | Johns Hopkins University | Participant Retention; Tolerability as assessed by number of side effects; Tolerability as assessed by severity of side effects | Fatigue as assessed by the Fatigue Severity Scale |
| NCT06211062 | The Use of Directed Probiotics in ME/CFS: Myalgic Encephalomyelitis/Chronic Fatigue Syndrome | RECRUITING | PHASE2 | Nova Southeastern University | The Incidence of Intervention-Related Adverse Events [Safety]; The Measurement of Biomarker Response to an Intervention in the Blood [Efficacy]; level of CRP (C-reactive protein); The pro-inflammatory cytokines level e.g. IL-1, IL-6, and TNF-α; The Symptom Sev | The Impact on the Irritable Bowel Syndrome (IBS) Severity; The IBS-related Quality of Life Measurement |
| NCT06821087 | Evaluating the Neuromodulatory Effect of Ketamine in Long COVID: A Pilot Study Targeting Fatigue and Neurocognitive Symptoms | ENROLLING_BY_INVITATION | PHASE2 | University of Texas at Austin | PROMIS SF v1.0 - Fatigue 8a; PROMIS SF v2.0 Cognitive Function 4a; BrainCheck Cognitive Battery; Number of participants with treatment-related adverse events as assessed by standardized interview | PROMIS Global 10 v1.2; NASA Task Load Index (NASA-TLX); Patient Health Questionnaire-9 (PHQ-9); Generalized Anxiety Disorder-7 (GAD-7); Depression in Medically Ill 10 Scale (DMI-10); Long COVID Review of Systems; Neuroimaging (MRI) Outcomes; Serum Biomarker An |
| NCT06492798 | Effectiveness and Safety of Mesenchymal Stem Cell Therapy in Long COVID Patients | RECRUITING | PHASE1; PHASE2 | Changhai Hospital | Common Terminology Criteria for Adverse Events (CTCAE5.0) | Common Terminology Criteria for Adverse Events (CTCAE5.0) |
| NCT06586398 | A Pilot Randomized Trial of rTMS for Fatigue and Brain Fog and Neuropsychiatric Symptoms of Long-COVID. | ACTIVE_NOT_RECRUITING | nan | University of California, Los Angeles | Tolerability as measured by Safteesi survey; Safety profile and adverse events | Subjective Cognitive impairment assessed by Multidimensional Inventory of Subjective Cognitive Impairment (MISCI); Fatigue assessed by Fatigue Severity Scale (FSS); Physical and mental health assessed by PROMIS-29; Alzheimer's Disease Assessment Scale (AD |
| NCT07108036 | Interleukin-15 Superagonist Nogapendekin Alfa Inbakicept in Participants With Long Covid. | RECRUITING | PHASE2 | ImmunityBio, Inc. | Incidence of treatment emergent adverse events (TEAEs) through 30 days post final study drug administration.; Incidence of grade 3 or higher TEAEs through 30 days post final study drug administration.; Incidence of serious adverse events (SAEs) through 30 days | Change in the ALC from Screening, INT1, FU1.3, INT2, FU2.3, FU2.4, FU2.5, and EOS.; Change in patient-reported outcomes (PROs) PROMIS-29 score from Baseline to FU2.5 (45 days following last NAI administration).; Change in other assessments (eg, EuroQoL Quality |
| NCT07123727 | Single Arm Study to Evaluate the Safety of Nogapendekin Alfa Inbakicept (NAI) in Participants With Long COVID | RECRUITING | PHASE2 | ImmunityBio, Inc. | Incidence of treatment emergent adverse events (TEAEs) through 30 days post final study drug administration.; Incidence of grade 3 or higher TEAEs through 30 days post final study drug administration.; Incidence of serious adverse events (SAEs) through 30 days | Percent increase or decrease change in the Absolute lymphocyte count (as measured on CBC) from Screening to End Of Study with various timepoints. |
| NCT07021794 | Effectiveness of Treating Post-COVID-19 Conditions (Long COVID) With the SARS-CoV-2 Specific Monoclonal Antibody, Sipavibart | RECRUITING | PHASE2 | Nancy Klimas | Patient-Reported Outcomes Measurement Information System-29; Review of Treatment Related Adverse Events | Symptom-specific participant-reported outcome measures; Change in Simple Reaction Time (Milliseconds); Self-reported fatigue using MFI; Change in Heart Rate Post-6MWT; Processing Speed; Attention; Systolic Blood Pressure Response During NASA Lean Test; Diastol |
| NCT04890483 | Transcranial Direct Current Stimulation in Post-Acute COVID-19 Patients With Systemic Autoimmune Rheumatic Diseases | RECRUITING | nan | University of Sao Paulo | Frequency of treatment-emergent adverse events [safety and tolerability]; Frequency of treatment-emergent adverse events [safety and tolerability]; Frequency of treatment-emergent adverse events [safety and tolerability]; Frequency of treatment-emergent advers | Health Assessment Questionnaire (HAQ) |
| NCT05688241 | Epstein-Barr Virus (EBV) -Specific T Memory Stem Cell (Tscm) Therapy to Treat EBV- Driven Lymphomas/ Diseases | NOT_YET_RECRUITING | PHASE1; PHASE2 | University Hospital, Basel, Switzerland | Assessment of feasibility to expand Tscm-enriched EBV CTLs; Safety of EBV Tscm-CTL infusion assessed by number of early infusion-related events; Safety of EBV Tscm-CTL infusion assessed by number of late clinical reaction to EBV Tscm-CTLs | nan |
| NCT05597800 | A Phase 2, Multicenter, Open Label, Clinical Trial Evaluating Safety and Activity of Nivolumab/Ipilimumab and Chemotherapy Combination in Advanced NSCLC Patients With HIV, HBV, HCV | NOT_YET_RECRUITING | PHASE2 | Universita di Verona | Safety, defined as onset of grade 3 or 4 (G3/4) treatment-related adverse events (TRAEs), assessed by the National Cancer Institute Common Toxicity Criteria (NCI-CTC) version 5.; Objective Response Rate (ORR) measured as for RECIST 1.1 criteria | Overall survival (OS); Progression-free survival (PFS); Duration of response (DOR) |
| NCT06611111 | Phase 1, Randomized, Double-Blind, Placebo-Controlled Trial of Pulse Dosed Ceftriaxone for Post-Treatment Lyme Disease | RECRUITING | EARLY_PHASE1 | State University of New York - Upstate Medical University | Number of abnormal laboratory measurements; Intensity of Abnormal Laboratory Measurements; Duration of Abnormal Laboratory Measurements; Occurrence of adverse events; Intensity adverse events; Duration of adverse events; Number of serious adverse events | Fatigue Severity Scale; SAFTEE assessment; SF-36 continuous variables; SF-36 Responder-Nonresponder; General Symptom Questionnaire; PROMIS-29; Lyme VlsE1/pepC10 Antibody |
| NCT05706454 | Randomized, Double-Blind, Placebo-Controlled, Parallel-Design, Multi- Centre, Adaptive Phase 2/Phase 3 Study To Evaluate The Efficacy And Safety Of Ramatroban Along With The Standa | UNKNOWN | PHASE2; PHASE3 | KARE Biosciences | Rate of Serious Adverse Events (SAE); Time to Clinical recovery (TTCR) | Composite endpoint of death or need for mechanical ventilation or ECMO; Rate of mechanical ventilation or vasopressor therapy, or ECMO; Ventilator free days; Duration of hospitalization; Duration of ICU stay; Number of subjects who had thrombotic events; Morta |
| NCT05776251 | Transcutaneous Auricular Vagus Nerve Stimulation (taVNS) for Persistent Symptoms From Lyme Disease: a Feasibility, Tolerability, and Safety Study | RECRUITING | nan | Columbia University | Recruitment Rate; Compliance Rate; Drop-out Rate; Ratings of Treatment Satisfaction (Likert Scale); Total Number of Treatment Emergent Adverse Events | nan |
| NCT05858515 | REVERSE-Long COVID: A Multicenter Randomized, Placebo-Controlled Clinical Trial of Immunomodulation (With Baricitinib) for Long COVID Related Cognitive Impairment and ADRD (Alzheim | WITHDRAWN | PHASE3 | Vanderbilt University Medical Center | Enrollment; Diversity in enrollment; Study drug prescribed; Study withdrawals; Adverse event reporting; Study dosing; Study completion | Severe and Serious Adverse Events; Premature study discontinuation; Global Neuropsychological Function; Cardiopulmonary testing; Everyday Cognition; Functional Status; Quality of Life Measures; Post-Exertional Malaise; Shortness of Breath; Symptom Burden; Infl |
| NCT06666153 | A Clinical Study Evaluating the Safety, Tolerability, and Initial Efficacy of Therapeutic Immunological Agent for EBV Lymphoproliferative Diseases | NOT_YET_RECRUITING | PHASE1 | West China Hospital | Safety and tolerability | Quality of life for patients; Effectiveness |
| NCT07388550 | Phase I Open-Label Safety Trial of Pembrolizumab for Neurological Post-Acute Sequelae of SARS-CoV-2 (PD1-PASC I) | NOT_YET_RECRUITING | PHASE1 | National Institute of Neurological Disorders and Stroke (NINDS) | The primary outcome of this study is to determine the safety of a single dose of intravenous Pembrolizumab in participants with neurological post-acute sequalae of SARS-CoV-2 infection. | To determine if one dose of intravenous Pembrolizumab can lead to clinically relevant improvement in subjective and objective measures of ability.; To determine if one dose of intravenous Pembrolizumab can normalize markers of immune exhaustion in neuro-PASC. |
| NCT05116761 | Bone Marrow Mesenchymal Stem Cell Derived Extracellular Vesicles Infusion Treatment for Post-Acute and Chronic Post-COVID-19 Syndrome: A Phase I/II Clinical Trial | WITHDRAWN | PHASE1; PHASE2 | Direct Biologics, LLC | Increased distance on Six Minute Walk Test (6MWT); Incidence of Serious Adverse Events (SAEs) | EuroQol-5D (EQ-5D); Medical Research Council (MRC) Dyspnea Scale |
| NCT05582603 | Detailed Study on the Safety, Dosage and Feasibility of an Intervention Based on a Computerized Cognitive Training (CCT) for Individuals With Post-acute Sequelae of COVID-19 (PASC) | UNKNOWN | PHASE1; PHASE2 | Universidad Antonio de Nebrija | Fatigue Level Questionnaire; Fatigue Level Questionnaire; Safety Level Questionnaire; Safety Level Questionnaire; Classification of side effect or adverse events; Classification of side effect or adverse events | Computerized Cognitive Assessment; Quality of Life Assessment; Paper-and-pencil Cognitive Assessment |
| NCT06534164 | Telerehabilitation of Balance Clinical and Economic Decision Support System | NOT_YET_RECRUITING | nan | University College, London | Recruitment Rate (acceptability); Incidence of Treatment-Emergent Adverse Events (safety); Feasibility (protocol deviations/problems); Participants experience using the system (usability); Adherence to Intervention; Drop-out rate (acceptability) | Mini Balance Evaluation Systems Test (Mini-BESTest); Functional Gait Assessment (FGA); Incremental cost-effectiveness ratio (ICER); EuroQol five dimensional descriptive system (EQ-5D-5L); Montreal Cognitive Assessment (MoCA); Rapid Assessment of Physical Activ |
| NCT07079787 | Telerehabilitation of Balance Clinical and Economic Decision Support System | NOT_YET_RECRUITING | nan | University College, London | Incidence of Treatment-Emergent Adverse Events (safety); Recruitment Rate (acceptability); Feasibility (protocol deviations/problems); Participants experience using the system (usability); Adherence to Intervention; Drop-out rate (acceptability) | Functional Gait Assessment (FGA); Mini Balance Evaluation Systems Test (Mini-BESTest); Montreal Cognitive Assessment (MoCA); EuroQol five dimensional descriptive system (EQ-5D-5L); Rapid Assessment of Physical Activity (RAPA); Dizziness Handicap Inventory (DHI |
| NCT06785402 | Phase 1/2, Randomized, Double-Blind, Placebo-Controlled Trial of Pulse Dosed Ceftriaxone for Post-Treatment Lyme Disease | WITHDRAWN | PHASE1; PHASE2 | Hackensack Meridian Health | Safety of pulse-dosed ceftriaxone; Tolerability of pulse-dosed ceftriaxone; Study Feasibility | Clinical Improvement - Physical and mental summary indices; Clinical Improvement - General Symptom Questionnaire (GSQ-30); Clinical Improvement - PROMIS-29; Clinical Improvement - Quantitative Lyme VlsE1/pepC10 Ab |
| NCT05932797 | EVALUATION AND IMPLEMENTATION OF A MULTIMODAL INTERVENTION TO REDUCE SYMPTOMS OF LONG COVID/PROLONGED COVID IN THE ADULT POPULATION OF PUNTA ARENAS, CHILE. | UNKNOWN | nan | Universidad de Magallanes | Number of participants with treatment-related adverse events assessed by Cardiorespiratory Capacity | Cardiorespiratory profiles; Cardiorespiratory profiles; Cardiorespiratory profiles; Psychological profiles; Psychological profiles; Neurocognitive profiles; Functional profiles; Quality of life indicators; Nutritional profile |
| NCT05855356 | The Long-CoviD Patients Causal Diagnosis and Rehabilitation Randomized Feasibility Controlled Trial in Patients With Dysautonomia: the LoCoDiRe-Dys Study | UNKNOWN | nan | Evangelismos Hospital | Number of patients with lack of definite Dysautonomia Diagnosis; Compliance, Adverse Events and Protocol Titration to examine feasibility of the trial | 10 minutes NASA Lean Test; Six minute Walk Test; 1 minute sit to stand test; Fatigue Severity Scale; modified Medical Research Council Dyspnea Scale; Nijmegen Questionnaire; Montreal Cognitive Assessment; International Physical Activity Questionnaire; Hospital |
| NCT05669261 | A PILOT STUDY ON RESEARCH TREATMENT OF LONG COVID POST-ACUTE SEQUELAE OF SARS CoV-2 INFECTION ("PASC") USING ATCell™ | UNKNOWN | PHASE1 | American CryoStem Corporation | Assessment of the Incidence of Serious Adverse Events (SAEs); Assessment of change in Health Status using the 36 item Short Form Health Survey (SF-36); Assessment of change in Health Status using the 36 item Short Form Health Survey (SF-36); Assessment of chan | Assessment of Changes in Exosome/Cytokine/Chemokine Testing; Assessment of change in completion time -Six-minute walk test (6MWT); Assessment of Change in Complete blood count with differential (CBC with diff) Laboratory Testing Results; Assessment of Change i |
| NCT06156241 | Long COVID: Cord Tissue-Derived Mesenchymal Stromal Cells for Persistent NeuroInflammatory Symptoms | UNKNOWN | PHASE1 | Charles Cox | Determine the safety and establish the maximum tolerated dose (MTD) of allogenic human cord tissue derived MSCs (hCTMSCs) as determined by infusional toxicity of the cell product.; Determine the safety and establish the maximum tolerated dose (MTD) of allogeni | Investigate if the hCTMSC infusions reduce the neuroinflammatory response following an acute COVID-19 infection as measured by the degree of microglial activation. |
| NCT06145867 | A Feasibility Study Assessing the Acceptability, Adherence, and Safety of Photobiomodulation (PBM) Therapy and Objective Assessment Measures in Myalgic Encephalomyelitis (ME) | UNKNOWN | nan | Quadram Institute Bioscience | Compliance of PBM therapy in ME patients.; Acceptance of PBM therapy in ME patients.; Safety of PBM therapy in ME patients. | Compliance of the GENEActiv accelerometers in ME patients; Acceptance of the GENEActiv accelerometers in ME patients; Safety of GENEActiv accelerometers in ME patients.; Changes in NeurOn (online cognitive function assessments) completion rates in ME patients. |
| NCT ID | Title | Status | Phase | Sponsor | Primary endpoint | Secondary endpoint |
|---|---|---|---|---|---|---|
| NCT05999435 | A DOUBLE-BLIND, RANDOMIZED, PLACEBO-CONTROLLED, ADAPTIVE PHASE 2/3 STUDY OF THE EFFICACY OF LAU-7b IN THE TREATMENT OF ADULTS WITH LONG COVID AND MODERATE TO SEVERE SYMPTOMS | COMPLETED | PHASE2; PHASE3 | Laurent Pharmaceuticals Inc. | Change From Baseline in Physical Component Summary (PCS) of the Medical Outcomes Study Short-Form-36 (SF-36) at Week 12 | Safety of LAU-7b, Overview; Patient Global Impression of Change (PGI-C); Proportion of Participants With Marked Improvement in PGI-C; Change From Baseline in the Functional Assessment of Chronic Illness Therapy Fatigue (FACIT-F) Scale; Change From Baseline in |
| NCT05074888 | A Multicenter, Double-blind, Placebo-controlled, Parallel-group, Randomized Clinical Trial of Efficacy and Safety of Prospekta in the Treatment of Patients With Post-COVID-19 Asthe | COMPLETED | PHASE3 | Materia Medica Holding | Change in the Mean FSS Score. | Change in Distance of the 6-minute Walk Test.; Change in the Severity of Anxiety on the HADS Subscale.; Change in the Severity of Depression on the HADS Subscale.; Change in the Mean FSS Score Within Follow-up Period.; Change in Distance of the 6-minute Walk T |
| NCT04920916 | Safety and Efficacy of the Treatment of Hospitalized Patients With COVID 19 Infection With an Inhibitor of IL-4 and IL-13 Signaling: A Phase IIa Trial | COMPLETED | PHASE2 | University of Virginia | Day 28 Ventilator Free Survival; Follow up Study 1 Year Outcome: Pulmonary Function Testing- Oxygen Diffusion and 6 Minute Walk Testing | Proportion of Patients With Eosinophilia; Cumulative Incidence of Grade 3 and 4 Clinical Adverse Events, Serious Adverse Events (SAEs) or Death; SARS-CoV-2 Variants; Change in Plasma Total Immunoglobulin E (IgE) Levels; Change in C-reactive Protein (CRP); Chan |
| NCT05965726 | RECOVER-VITAL: A Platform Protocol for Evaluation of Interventions for Viral Persistence, Viral Reactivation, and Immune Dysregulation in Post-Acute Sequelae of SARS-CoV-2 Infectio | COMPLETED | PHASE2 | Kanecia Obie Zimmerman | Percentage of Participants Who Improved in Cognitive Dysfunction Symptom Cluster, as Measured by Patient-Reported Outcomes Measurement Information System (PROMIS) Cognitive 8a Function T-score; Percentage of Participants Who Improved in Autonomic Dysfunction S | Percentage of Participants Who Improved in Cognitive Dysfunction Symptom Cluster, as Measured by a Neurocognitive Battery; Percentage of Participants Who Improved in Autonomic Dysfunction Symptom Cluster, as Measured by the Active Stand Test; Percentage of Par |
| NCT03356821 | Adult Mesenchymal Stromal Cells to Regenerate the Neonatal Brain: the PASSIoN Trial (Perinatal Arterial Stroke Treated With Stromal Cells IntraNasally) | COMPLETED | PHASE1; PHASE2 | UMC Utrecht | Number of Participants With Adverse Events Related to Intranasal MSC Treatment (Safety and Tolerability) in the Acute Setting. | Number of Participants With Adverse Events Related to Intranasal MSC Treatment (Safety and Tolerability) in the Subacute/Long-term Setting |
| NCT06214455 | The Effect of a No-added Sugar Diet, Time-restricted Eating and Periodic Water Fasting on Long COVID Symptoms | COMPLETED | nan | Pacific Northwest University of Health Sciences | Change in LC-Score, Per Treatment; Change in Number of Long COVID Symptoms, Per Treatment | Change in LC-Score, Overall; Change in Number of Long COVID Symptoms, Overall; Serious Adverse Events |
| NCT06524739 | Double-blind, Randomized, Placebo-controlled Phase 3 Study Evaluating Efficacy and Safety of IgPro20 (Subcutaneous Immunoglobulin, HIZENTRA®) in Post-COVID-19 Postural Orthostatic | TERMINATED | PHASE3 | CSL Behring | Proportion of Participants No Longer Meeting Diagnostic Criteria of Post-COVID POTS as Measured by Standardized Standing Test (ie, No Longer Experiencing HR Increase of ≥30 Bpm, in the Absence of 20 mmHg Decrease of SBP [Orthostatic Hypotension]) | Change From Baseline in Orthostatic Intolerance (OI) Score of Composite Autonomic Symptom Score 31 (COMPASS-31); Change From Baseline in COMPASS-31 Total Score; Change From Baseline in Heart Rate Increase Within 10 Minutes of Standing Test; Number of Participa |
| NCT05946551 | Feasibility Assessment of a Decentralized Platform Adaptive Double-Blind, Randomized Controlled Trial Investigating Repurposed Drugs in the Treatment of Post-Acute Sequelae of Coro | TERMINATED | PHASE3 | Emory University | Number of Participants That Had Any Confusion Over How to Take the Study Drug, Including Which Pill to Take, When to Take it, or How Many to Take; Number of Participants That Had Trouble Adhering to the Study Drug Schedule; Number of Participants That Had Any | Proportion of Survey Completion; Proportion of Study Drug Adherence; Proportion of Lost to Follow Up (LFUP); Proportion of Voluntary Termination; Adverse Events (AEs) Incidence; Serious, Unexpected Suspected Adverse Reactions (SUSAR) Incidence; Study-wide Seri |
| NCT04313972 | IC PaIN Trial: Interstitial Cystitis Pain Improvement With Naltrexone, the Effect of Low Dose Naltrexone on Symptoms and Pain of Patients With Interstitial Cystitis/Painful Bladder | TERMINATED | PHASE4 | Endeavor Health | Interstitial Cystitis Symptom Index; Visual Analog Scale | Change in Interstitial Cystitis Problem Index; Change in Urinary Frequency; Change in Number of Nocturia; Change in Pelvic Pain and Urgency/Frequency Symptoms; Change in Pelvic Pain and Urgency/Frequency Bother; Patient Perceived Quality of Life: SF-36; Advers |
| NCT05795816 | The Effectiveness of Testofen on Energy, Fatigue, Mental Acuity, and Other Quality of Life Symptoms Post COVID-19 Infection | COMPLETED | PHASE3 | RDC Clinical Pty Ltd | Change in Energy and Fatigue; Change in Energy and Fatigue | Change in Memory; Change in Mental Acuity; Change in Muscle Strength (Hand grip); Change in Hair loss/growth; Change in Libido; Change in Stress and Mood; Change in Quality of Life Indicators; Change in Pathology results via Blood test; Change in Weight; Heigh |
| NCT05911906 | An Open-label, Clinical Feasibility Study of the Efficacy of Remdesivir for Long-COVID. | COMPLETED | PHASE4 | University of Derby | To assess the feasibility of the use of Remdesivir in the treatment of patients with Long COVID.; To assess the feasibility of the use of Remdesivir in the treatment of patients with Long COVID.; To assess the feasibility of the use of Remdesivir in the treatm | To identify the most clinically relevant primary outcome for the definitive study; To identify the most clinically relevant primary outcome for the definitive study; To identify the most clinically relevant primary outcome for the definitive study; To identify |
| NCT05642923 | Post-COVID-19 Chronic Fatigue Syndrome | COMPLETED | PHASE4 | ClinAmygate | Fatigue scale; Fatigue scale; Fatigue scale | Incidence of adverse events |
| NCT06128967 | An Adaptive, Randomized, doublE-blind, Placebo-controlled, Prospective, Pharmacological interVention Study In Participants With Long COVID-19 Syndrome: REVIVE-TOGETHER Trial | COMPLETED | PHASE3 | Cardresearch | Improvement on Fatigue Severity Score Scale (FSS) | Improvement on Fatigue Severity Score Scale (FSS); Improvement on Fatigue Severity Score Scale (FSS); Reduction on any cause hospitalization; Safety of metformin; Safety of Fluvoxamine; Death of any cause |
| NCT05668091 | An Interventional Decentralized Phase 2, Randomized, Double-Blind, 2-Arm Study to Investigate the Efficacy and Safety of Orally Administered Nirmatrelvir/Ritonavir Compared with Pl | COMPLETED | PHASE2 | Harlan M Krumholz | National Institutes of Health (NIH) Patient-Reported Outcomes Measurement Information System (PROMIS)-29 version 2.1 Physical Health Summary Score | Modified General Symptom Questionnaire-30 (Modified GSQ-30); PROMIS® Cognitive Function v.2.0 - Short Form 6a; COVID Core Outcome Measure for Recovery; EuroQol EQ-5D-5L Utility Score-VAS (USA Version); Functional Assessment of Chronic Illness Therapy (FACIT)-I |
| NCT06055244 | Amantadine Therapy for Cognitive Impairment Related to Post-COVID Condition | COMPLETED | PHASE2 | Ohio State University | Improvement in cognitive symptoms; Improvement on objective cognitive testing | Mood symptoms; Medication tolerability |
| NCT05852873 | PAxlovid loNg cOvid-19 pRevention triAl With recruitMent In the Community in Norway | ACTIVE_NOT_RECRUITING | PHASE3 | Haukeland University Hospital | Symptoms of long-COVID | Symptoms individually and grouped by organ system; Graded responses for symptoms and symptom constellations; Risk factors for long-COVID; Severity of acute disease; Hospitalisation; Severe adverse events; Absence from work; Societal costs; Symptoms of long-COV |
| NCT06305806 | RECOVER-AUTONOMIC (Ivabradine): Randomized Trial of the Effect of Ivabradine Versus Placebo on Long COVID Symptoms | COMPLETED | PHASE2 | Kanecia Obie Zimmerman | Change in Orthostatic Hypotension Questionnaire (OHQ)/Orthostatic Intolerance Questionnaire (OIQ) Composite Score | Change in Composite Autonomic Symptoms Score 31 (COMPASS-31); Change in Malmo POTS Symptom Score; Change in heart rate (HR); Change in 6-min Walk Test; Change in PROMIS-29 + 2 Questionnaire; Characterize the safety and tolerability of study intervention for tr |
| NCT05497089 | Temelimab as a Disease Modifying Therapy in Patients With Neurological, Neuropsychological, and Psychiatric (=Neuropsychiatric) Symptoms in Post-COVID 19 or Postacute Sequelae of C | COMPLETED | PHASE2 | GeNeuro SA | Improvement in fatigue in PASC patients | Fatigue; Cognitive function; Cognitive function; Cognitive function; Cognitive function; Anxiety; Depression; Overall quality of Life; Functional impairment; Post-COVID-19 Functional Status; Safety and tolerability of Temelimab in PASC patients |
| NCT04828668 | A Single-Blind, Randomized, Placebo Controlled, Study to Evaluate the Benefits and Safety of Endourage Targeted Wellness Formula C™ Sublingual Drops in People With Post -Acute COVI | COMPLETED | nan | Endourage, LLC | Reduction in patient reported outcomes measures on the Patient Reported Outcomes Measurement Information System (PROMIS ®) assessment tools.; PATIENT GLOBAL IMPRESSION OF CHANGE (PGIC) | Study product related adverse events and side effects. |
| NCT05710770 | Double-blinded, Randomized, Sham-controlled Trial of Immunoadsorption (IA) in Patients With Chronic Fatigue Syndrome (CFS) Including Patients With Post-acute COVID-19 CFS (PACS-CFS | COMPLETED | nan | Charite University, Berlin, Germany | Improvement in physical and mental fatigue as measured by the Chalder Fatigue Scale | Sustained improvement quantified by the Chalder Fatigue Scale; Verification of safety and tolerability of immunoadsorption in this patient population; Improvement in severity of symptoms of chronic fatigue syndrome (CFS) as measured by the Fluge score; Improve |
| NCT04308278 | Randomized, Placebo-controlled, Double Blind Study to Evaluate the Efficacy of 2LEBV® and 2LXFS® on Asthenia in Patients With an Epstein-Barr Virus Infection. | RECRUITING | PHASE4 | Labo'Life | Measure of the general fatigue scale of the Multidiensional Fatigue Inventory-20 (MFI-20) questionnaire at the end of the treatment. | Comparison of the efficacy of the treatment on physical fatigue, reduced activity, reduced motivation and mental fatigue scales on the MFI-20 questionnaire between the 2LEBV® or the 2LXFS®/2LEBV® group versus the placebo group; Comparison of the efficacy of th |
| NCT07280572 | RECLAIM: an Adaptive Platform Trial for the Evaluation of Treatments for Post-Acute Sequelae of SARS-CoV-2 Infection (PASC) | ENROLLING_BY_INVITATION | PHASE3 | Janneke van de Wijgert | Physical health-related quality of life (HRQoL) | Mental HRQoL; Other aspects of HRQoL; Fatigue; Post Exertional Malaise (PEM); Cognitive functioning; Post Orthostatic Tachycardia Syndrome (POTS); Safety of IPs; Tolerability of IPs; Durability of IP treatment responses |
| NCT05273372 | A Randomized Double Blind Placebo Controlled Trial to Determine the Effects of Oxaloacetate on Improving Fatigue in ME/CFS | COMPLETED | nan | Terra Biological LLC | Reduction of Fatigue | Number of participants with treatment-related adverse events as assessed by CTCAE v4.0; Physical Functioning on the SF-36; Patient Global Impression of Change Questionnaire, 7 point scale, -3 to +3, with the higher score indicating more improvement |
| NCT05798221 | Complementary Self-help Strategies for Patients With Post-COVID-19 Syndrome: A Randomized Controlled Trial | COMPLETED | nan | Universität Duisburg-Essen | Post-COVID-19 symptom burden | Post-COVID-19 symptom burden; Post-COVID-19 functional status (self-reported); Post-COVID-19 functional status (self-reported); Health-related quality of life; Health-related quality of life; Fatigue; Fatigue; Anxiety and depression; Anxiety and depression; In |
| NCT05697640 | A Parallel-group Treatment, Phase 2a, Double-blind, Placebo-controlled 2-arm Study to Show Improvement of Physical Function in SF-36 (SF-36-PF) in Participants Treated With Vericig | ACTIVE_NOT_RECRUITING | PHASE2 | Charite University, Berlin, Germany | Improvement in Physical Function (PF) as measured by the Short Form 36 Health Survey Questionnaire (SF-36) | Difference in responder rate in Physical Function (PF) as measured by the Short Form 36 Health Survey Questionnaire (SF-36) comparing Vericiguat with placebo; Improvement in other sub-domains of the Short Form 36 Health Survey Questionnaire (SF-36) comparing V |
| NCT04751669 | Efficacy of Micronutrient Dietary Supplementation in Reducing Hospital Admissions for COVID-19: A Double-blind, Placebo-controlled, Randomized Clinical Trial | COMPLETED | nan | Fundació Institut Germans Trias i Pujol | Need for hospital admission; Incidence of Long Covid. | Micronutrient basal status (Vitamin B1, Vitamin B6, 25-OH-Vitamin D and Folic Acid; Micronutrient basal status (Vitamin B12); Micronutrient basal status (Iron, Zinc and Copper ); Micronutrient basal status (Vitamin A and Vitamin E); Micronutrient basal status |
| NCT07553897 | Effectiveness of a Tele-Exercise Training Program on Long COVID Symptoms and Quality of Life in Patients With Long COVID | COMPLETED | nan | Tri-Service General Hospital | Long COVID Symptoms; Cardiorespiratory Fitness - Peak Oxygen Uptake (VO₂peak); Cardiorespiratory Fitness - Peak Workload; Cardiorespiratory Fitness - Anaerobic Threshold; Health-Related Quality of Life | Safety and adverse events |
| NCT05965739 | RECOVER-NEURO: A Platform Protocol for Evaluation of Interventions for Cognitive Dysfunction in Post-Acute Sequelae of SARS-CoV-2 Infection (PASC) | COMPLETED | nan | Duke University | Change in Everyday Cognition 2 (ECog2) | Change in PROMIS-cognitive function - short form 8a (PROMIS-Cog) total score; Change on an objective neurocognitive battery scores; Change in Everyday Cognition 2 (ECog2); Characterize the intervention's safety as measured by the proportion of Serious Adv |
| NCT05841498 | A Single-blinded Sham-controlled Crossover Trial to Evaluate the Effect of Immunoadsorption on Post-Corona Virus Disease (COVID)-Syndrome | COMPLETED | nan | University Medical Center Mainz | Improvement of Post-COVID symptoms as measured by PCFS score; Change of physical and/or mental fatigue as measured by Chalder-Fatigue-scale; Change of impairment due to fatigue as measured by Bell-Score; Change of physical and/or mental fatigue as measured by | number of treatment-emergent adverse events (TEAE), serious adverse events and discontinuation of therapy because of adverse events; Prevalence of anti-adrenergic and anti-muscarinic autoantibodies in patients with PCS:; 3. Concentration of autoantibodies befo |
| NCT06305793 | RECOVER-AUTONOMIC (IVIG): Randomized Trial of the Effect of IVIG Versus Placebo on Long COVID Symptoms | ACTIVE_NOT_RECRUITING | PHASE2 | Kanecia Obie Zimmerman | Change in Orthostatic Hypotension Questionnaire (OHQ)/Orthostatic Intolerance Questionnaire (OIQ) Composite Score | Change in Composite Autonomic Symptoms Score 31 (COMPASS-31); Change in Malmo POTS Symptom Score; Change in Active Stand Test; Change in blood pressure; Change in heart rate (HR); Change in 6-min Walk Test; Change in Patient-Reported Outcomes Measurement Infor |
| NCT06928272 | LC-REVITALIZE - A Long Covid Repurposed Drug Study | RECRUITING | PHASE3 | Douglas D. Fraser | Symptom Burden Questionnaire (SBQ) Subscales | General participant reported overall well-being using the Patient Reported Outcome Measurement Information System (PROMIS)-29 questionnaire; General participant reported overall well-being using the Generalized Anxiety Disorder (GAD)-7 questionnaire; General p |
| NCT06695910 | Modulation of the Brain Fog Scale by Eicosapentaenoic Acid Monoglycerides (MAG-EPA) in Volunteers Who Reported Suffering From Haze or Mental Fatigue on a Regular Basis. Exploratory | RECRUITING | PHASE4 | Samuel Fortin | Cognitive health assessment with the Brain Fog Scale (BFS) | Omega-3 intake assessment by Omega-3 index analysis; Demographic data analysis; Adverse Event reporting |
| NCT06597396 | A Phase 2a Randomized, Dose Ranging, Double-Blind, 3-Arm Study to Investigate Orally Administered Abrocitinib Compared With Placebo in Non-Hospitalized Symptomatic Adult Participan | ACTIVE_NOT_RECRUITING | PHASE2 | Beth Israel Deaconess Medical Center | Change from baseline in mean score for FACIT (Functional Assessment of Chronic Illness Therapy) Fatigue Scale | Change from baseline for EQ(EuroQol)-5D-5L values and visual analog scale (VAS) score to Day 84; Change from baseline in PASC Symptom PRO (patient reported outcome) Instrument score to Day 84; Safety-related clinical laboratory test abnormalities and related a |
| NCT06593600 | A Phase 2 Double-Blind Placebo-Controlled Single-Dose Study of Pharmacodynamics, Pharmacokinetics, Safety, and Tolerability of REGN7544, an NPR1 Antagonist Monoclonal Antibody, in | ACTIVE_NOT_RECRUITING | PHASE2 | Regeneron Pharmaceuticals | Change in Heart Rate (HR) from supine to standing (DeltaHR) | Occurrence of Treatment-Emergent Adverse Events (TEAEs); Severity of TEAEs; DeltaHR; Supine HR; Standing HR; Supine blood pressure (BP); Standing BP; Concentrations of REGN7544 in serum; Incidence of anti-drug antibodies (ADAs) to REGN7544; Titer of ADAs to RE |
| NCT06189066 | Long COVID Ultrasound Trial [LOCUS Trial] | COMPLETED | nan | SecondWave Systems Inc. | Within-arm change in the endurance shuttle walk test (ESWT) from baseline to the completion of an up-to 8-week intervention period. | Within-arm change in the Chalder fatigue scale (CFQ-11; Likert score) from baseline to the completion of an up-to 8-week intervention period.; Track adverse events throughout the study to assess the safety of the ultrasound intervention. |
| NCT05356936 | Pilot Study of Vitamin K2 (MK-7) and Vitamin D3 Supplementation and the Effects on PASC Symptomatology and Inflammatory Biomarkers | COMPLETED | nan | University Hospitals Cleveland Medical Center | Change in high-sensitivity C-reactive protein (hs-CRP) as measured by blood test; Change in interleukin 6 (IL-6) as measured by blood test; Change in intestinal fatty acid binding protein (Ifab) as measured by blood test; Change in soluble Tumor Necrosis Facto | Percent of subjects with >Grade 2 adverse events as measured by patient report |
| NCT06792214 | Antiviral Strategies in the Prevention of Long-term Cardiovascular Outcomes Following COVID-19: The paxloviD/Remdesivir Effectiveness For the prEvention of loNg coviD (DEFEND) Clin | RECRUITING | PHASE4 | Mount Sinai Hospital, Canada | Recruitment rate; Post-acute sequelae of COVID-19 (PASC) | Administrative data validation; Reinfection, ICU admission, and drug safety |
| NCT06974084 | A Multi-Center Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy of Maraviroc and Atorvastatin for the Treatment of Subjects With Long COVID/Post-Acute Se | NOT_YET_RECRUITING | PHASE2; PHASE3 | HealthBio, Inc. | Fatigue | Improvement in dysautonomia symptoms as reflected by the Composite Autonomic Symptom Score (COMPASS-31); Improvement in Dyspnea; Improved Cognitive Function, measured by the PROMIS (Patient-Reported Outcomes Measurement Information System) Cognitive Function v |
| NCT06952413 | An Exploratory, Placebo-controlled, Double-blind, Phase II Study of the Efficacy and Safety for Rituximab (Genetical Recombination) in Myalgia Encephalomyelitis/Chronic Fatigue Syn | RECRUITING | PHASE2 | National Center of Neurology and Psychiatry, Japan | Improvement rate | Percentage of patients whose MHLW-PS-based ME/CFS severity score improved by 1 or more at each evaluation point (improvement rate) compared to that before the start of treatment with the investigational drug (week 0).; The amount of change in the severity scor |
| NCT06204458 | Evaluation of the Efficacy of Mild Water-filtered Infrared-A Whole-body Hyperthermia to Improve Symptoms and Quality of Life in Patients With Post-COVID Syndrome (HyPoCo) | ACTIVE_NOT_RECRUITING | nan | Universität Duisburg-Essen | Multidimensionl Fatigue Inventory (MFI-20); Multidimensionl Fatigue Inventory (MFI-20) | Multidimensionl Fatigue Inventory (MFI-20); Brief Pain Inventory (BPI) - Intensity of pain (Numeric Rating Scale, NRS); Brief Pain Inventory (BPI) - Intensity of pain (Numeric Rating Scale, NRS); Brief Pain Inventory (BPI) - Intensity of pain (Numeric Rating S |
| NCT06492798 | Effectiveness and Safety of Mesenchymal Stem Cell Therapy in Long COVID Patients | RECRUITING | PHASE1; PHASE2 | Changhai Hospital | Common Terminology Criteria for Adverse Events (CTCAE5.0) | Common Terminology Criteria for Adverse Events (CTCAE5.0) |
| NCT07316127 | A Placebo-Controlled, Double-Blind, Randomized Trial Phase I-II With Immunoadsorption in Autoimmune Long COVID | RECRUITING | PHASE2 | Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) | Change in fatigue measured by the Fatigue Assessment Scale (FAS) | Change in health related quality of life using the 36-Item Short Form Health Survey (SF-36); Change in cognitive functioning using the Patient-Reported Outcomes Measurement Information System (PROMIS®) Cognitive Function Short Form 8a (PROMIS Cognitive Functio |
| NCT07184385 | A Multicenter, Double-blind, Randomized, Placebo-controlled, Two-arm Phase III Study to Assess the Efficacy of Human Umbilical Cord Blood (REGENECYTE) Infusion in Reducing Fatigue | NOT_YET_RECRUITING | PHASE3 | StemCyte, Inc. | The change of efficacy | Treatment-emergent adverse events (TEAEs) |
| NCT06766825 | Phase II Proof-of-concept, Randomized, Double-blind, Placebo-controlled Study to Evaluate the Efficacy and Safety of Plitidepsin in Adults With Post-COVID-19 Condition (PCC) | RECRUITING | PHASE2 | Fundación FLS de Lucha Contra el Sida, las Enfermedades Infecciosas y la Promoción de la Salud y la Ciencia | Change in the overall health in patients from each group using patient reported outcomes measurement information system score (PROMIS-29®). | To compare the safety/tolerability of Plitidepsin Vs placebo in terms of adverse events in patients with PCC.; To compare the incidence of Treatment-Emergent Adverse Events (TEAEs) between groups.; To compare changes in the overall health in patients from each |
| NCT07567274 | Single-Arm Pilot Study of Compounded DMSO-Based Dual-Route Therapy for Refractory Subjective Tinnitus in PASC and Post-COVID-19 Vaccine Injury | ENROLLING_BY_INVITATION | PHASE2 | Leading Edge Clinic | Proportion of participants with at least 50% reduction in Tinnitus Handicap Inventory (THI) score | Change in Tinnitus Handicap Inventory (THI) score over time; Change in tinnitus loudness on visual analog scale (VAS); Change in tinnitus annoyance/distress on visual analog scale (VAS); Change in sleep interference due to tinnitus on visual analog scale (VAS) |
| NCT06936319 | Physical Counterpressure Maneuvers in Postural Orthostatic Tachycardia Syndrome (POTS) - a Monocentric, Randomized Controlled Trial | RECRUITING | nan | Medical University Innsbruck | Malmö Postural Orthostatic Tachycardia Syndrome symptom score (MAPS) | Severity of orthostatic intolerance (on a 0 - 10 points scale); Absolute heart rate; Absolute systolic and diastolic blood pressure; Supine-to-standing change in heart rate; Supine-to-standing change in systolic and diastolic blood pressure; Single items of th |
| NCT06865222 | Variable Pulse Transcranial Magnetic Stimulation for Treatment of Post COVID Syndrome | RECRUITING | nan | Mayo Clinic | Change in University of Pennsylvania Smell Identification Test (UPSIT) Olfactory Threshold Test score; Change in Tinnitus Handicap Inventory Scale score; Change in Modified Fatigue Impact Scale score | Change in General Anxiety Disorder-7 (GAD-7) score; Change in Patient Health Questionnaire-9 score; Change in PROMIS Global-10 score; Change in alpha wave characteristics measured via EEG.; Number of serious adverse events (SAEs) |
| NCT05682196 | Open-label, Randomized Controlled Trial to Assess Efficacy and Safety of Rituximab in Patients With Acute Rheumatic Fever in Africa | SUSPENDED | PHASE2 | African Academy of Methodology and Statistics | Rheumatic valvular lesions rate | Incidence of rheumatic valvular lesions; Serious adverse events rates |
| NCT07197138 | Pilot Study on the Effects of Intensified Repetitive Transcranial Magnetic Stimulation on Immunological Blood Parameters in Patients With Depression and Comorbid Post-COVID-19 Cond | RECRUITING | nan | Max-Planck-Institute of Psychiatry | Change in immunophenotypic marker CRP from baseline to post-treatment; Change in immunophenotypic marker TNF from baseline to post-treatment; Change in immunophenotypic marker IL-1ß from baseline to post-treatment; Change in immunophenotypic marker IL-6 from b | Change in Fatigue Severity Scale (FSS, self-rating); Change in Fatigue Scale for Motor and Cognitive Functions (FSMC, self-rating); Change in Post-Exertional Malaise (PEM) Questionnaire (self-rating); Change in Pittsburgh Sleep Quality Index (PSQI, self-rating |
| NCT05817019 | A Double-blind, Randomized, Parallel Design Study to Compare Postoperative Recovery Between the Sugammadex Group and the Neostigmine Group in Patients After COVID-19. | UNKNOWN | PHASE4 | Korea University Ansan Hospital | urinary retention incidence | surgery time and anesthesia time; recovery time after anesthesia; intraoperative blood loss; perioperative vital signs; additional sugammadex administration; bladder volume evaluated; recovery score; pain score; urinary retention; acute lesion on chest X-ray; |
| NCT06928506 | RECLAIM: Recovering From COVID-19 Lingering Symptoms Adaptive Integrative Medicine Trial - Effect of Hi-OxSR for the Treatment of Post COVID Condition (RECLAIM-HiOxSR) | RECRUITING | nan | University Health Network, Toronto | Simple reaction time (SRT) task from the TestMyBrain (TMB) Digital Neuropsychology Toolkit On-line survey tool; Verbal paired associates (VPA) task from the TestMyBrain (TMB) Digital Neuropsychology Toolkit On-line survey tool | All cognitive performance tasks (measured by the TESTMYBRAIN.org (TMB) neuropsychology toolkit; Brain Fog Questionnaire; Brief Fatigue Inventory; Short Form (SF)-36; Safety, adverse events and serious adverse events; Symptom Checklist; The DePaul Symptom Post- |
| NCT04801940 | HElping Alleviate the Longer-term Consequences of COVID-19 (HEAL-COVID): a National Platform Trial | UNKNOWN | PHASE3 | Cambridge University Hospitals NHS Foundation Trust | Hospital free survival. | All-cause mortality; Hospital readmission after discharge from index hospital admission; Suspected Serious Adverse Reactions; FACIT-Fatigue; Modified MRC Dyspnoea Scale; COVID-19 core outcome measure for recovery; Patient Health Questionnaire-2 (PHQ-2); Genera |
| NCT07110714 | Effects of Kneipp Hydrotherapy in Post-COVID-19 Patients: A Randomized Controlled Trial | RECRUITING | nan | Eggensberger OHG | Health-related quality of life by Short Form-12 Health Survey (SF-12) | Fatigue severity by Fatigue Severity Scale; Sleep quality by Pittsburgh Sleep Quality Index; Health status by EuroQol-5 Dimensions-5 Levels; Autonomic function (heart rate variability by photoplethysmography); Resting blood pressure (systolic and diastolic); P |
| NCT06147050 | Pilot Study of an Adaptive, Double-blind, Randomized, Placebo-controlled Study to Evaluate the Effect of Metformin in Reducing Fatigue in Long COVID Adolescent Patients With Chroni | UNKNOWN | PHASE3 | Purpose Life Sciences | Mean Pediatric Quality of Life Multidimensional Fatigue Scale (PedsQL-MFS) score at 90 days post-randomization | Mean PedsQL-MFS score at 30 days post-randomization; Mean PedsQL-MFS score at 60 days post-randomization; Mean Chalder Fatigue Scale (CFS) score at 30 days post-randomization; Mean CFS score at 60 days post-randomization; Mean CFS score at 90 days post-randomi |
| NCT05858515 | REVERSE-Long COVID: A Multicenter Randomized, Placebo-Controlled Clinical Trial of Immunomodulation (With Baricitinib) for Long COVID Related Cognitive Impairment and ADRD (Alzheim | WITHDRAWN | PHASE3 | Vanderbilt University Medical Center | Enrollment; Diversity in enrollment; Study drug prescribed; Study withdrawals; Adverse event reporting; Study dosing; Study completion | Severe and Serious Adverse Events; Premature study discontinuation; Global Neuropsychological Function; Cardiopulmonary testing; Everyday Cognition; Functional Status; Quality of Life Measures; Post-Exertional Malaise; Shortness of Breath; Symptom Burden; Infl |
| NCT07013903 | Effects of Kneipp Hydrotherapy During Inpatient Post-Covid-19 Rehabilitation: A Randomized Controlled Trial | RECRUITING | nan | Schön Klinik Berchtesgadener Land | Health-related quality of life by Short Form-12 Health Survey (SF-12) | Fatigue severity by Fatigue Severity Scale; Sleep quality by Pittsburgh Sleep Quality Index; Health status by EuroQol-5 Dimensions-5 Levels; Autonomic function (heart rate variability by photoplethysmography); Resting blood pressure (systolic and diastolic); P |
| NCT07285707 | Acupuncture for Long COVID - A Pragmatic Pilot Study | RECRUITING | nan | Southern California University of Health Sciences | Feasibility of Implementing a Combined Acupuncture and Chinese Herbal Medicine Intervention for long COVID | Patient-Reported Acceptability of the Study Procedures and Treatments; Clinician-Reported Acceptability of the Study Protocol; Change in Health-Related Quality of Life Measured by PROMIS-29 v2.1; Change in Symptom Burden Measured by the Symptom Burden Question |
| NCT05890599 | Randomized Multicenter Clinical Trial: Yoga Versus Health Education for the Treatment of Persistent Fatigue in Patients With Post COVID-19 Syndrome | RECRUITING | nan | University Hospital Tuebingen | Fatigue | Fatigue; Health related quality of life SF-12; Health related quality of life SF-12; Health related quality of life EQ-5D-5L; Health related quality of life EQ-5D-5L; Psychological symptoms; Psychological symptoms; Sleep quality; Sleep quality; Stress; Stress; |
| NCT05986422 | Phase 2a, Double-blind, Randomized, Placebo-controlled Trial of Methylprednisolone Versus Placebo in Patients With Cognitive Deficits in Post-COVID-19 Syndrome (PCS) | TERMINATED | PHASE2 | Charite University, Berlin, Germany | Improvement in memory satisfaction as measured by the Multifactorial Memory Questionnaire (MMQ) | Long-term improvement in memory satisfaction as measured by the Multifactorial Memory Questionnaire (MMQ); Improvement in memory ability and memory strategy as measured by the Multifactorial Memory Questionnaire; Improvement in neurocognitive functions as meas |
| NCT07546539 | The Role of Photobiomodulation in Patients With Chronic Fatigue Syndrome | NOT_YET_RECRUITING | nan | University of Lahore | Fatigue Improvement | Health Related Quality of Life; Functional Capacity; Pain Intensity; Sleep Quality; Psychological Well-Being; Sustained Effects; Safety and Tolerability; Adverse Effects and Safety Profile |
| NCT07397910 | Clinical Trial to Analyze the Effectiveness of a Natural Compound on Chronic Immune-mediated Inflammatory Status in Subjects Who Have Had SARS-CoV-2 Infection. | NOT_YET_RECRUITING | nan | Universidad Católica San Antonio de Murcia | Immunoinflammatory profile | Clinical signs; Short Form 12 Health Survey; Sleep quality; Sleep efficiency; Fatigue; Dyspnea; Depression; Anxiety; Hospital Anxiety and Depression; Stress level; Cardiorespiratory fitness.; The Rate of Force Development; Maximum Voluntary Isometric Contracti |
| NCT05684952 | The Efficacy and Safety of a Chinese Herbal Medicine (Shenlingcao Oral Liquid) for Treating Long COVID Associated Fatigue：a Double-blinded, Placebo-controlled, Randomized Clinical | UNKNOWN | PHASE2 | Hong Kong Baptist University | Fatigue: Change of scores in Chalder fatigue scale (0-33 points) | Insomnia: Change of scores in Insomnia Severity Index (ISI); Quality of life: Change of scores in 36-Item Short Form Survey (SF-36); Mood: Change of scores in The Hospital Anxiety and Depression Scale (HADS); Muscle strength: Change of Hand Grip Strength (HGS) |
| NCT06095258 | A Practical Clinical Randomized Controlled Trial of Traditional Chinese Medicine in the Treatment of Long COVID and an Analysis of Syndrome Types and Medication Characteristics of | UNKNOWN | PHASE2 | Chinese University of Hong Kong | 5-level EQ-5D version (EQ-5D-5L); 5-level EQ-5D version (EQ-5D-5L) | Measure Yourself Medical Outcome Profile in Chinese version (CMYMOP2); Measure Yourself Medical Outcome Profile in Chinese version (CMYMOP2); Modified COVID-19 Yorkshire Rehabilitation Scale (C19-YRSm); Modified COVID-19 Yorkshire Rehabilitation Scale (C19-YRS |
| NCT06386133 | Chronic Fatigue in Multiple Sclerosis: Validating Clinical Performance, Economic, and Organizational Benefits of MSCopilot Boost Compared to Standard Care | NOT_YET_RECRUITING | nan | Ad scientiam | To demonstrate that MSCopilot Boost is superior to standard practice in reducing the impact of fatigue on Patients with Multiple Sclerosis | To evaluate the impact of fatigue in both groups.; To compare the effect of MSCopilot Boost in reducing fatigue impact compared to standard practice (Short term and Medium term); To compare the fatigue impact between the two groups.; To compare the effect of M |
| NCT06141317 | Tissue Regeneration and Function Recovery in Patients With Parkinson's Disease Using Allogenic Pluripotent Stem Cells Isolated From Adipose Tissue (PASCs): A Randomized Phase | UNKNOWN | PHASE1; PHASE2 | ClusterXStem-Costa Rica | Change in motor function as assessed by the Unified Parkinson's Disease Rating Scale (MDS-UPDRS) Total Score; Quality of life as assessed by the 39-item Parkinson's disease Questionnaire (PDQ-39); Speech voice sound and duration; Dynamic balance and | Adverse events upon clinical examination; Optimal number of doses of 2.5 x 10^7 PASCs for therapeutic response |
| NCT04924881 | Chinese Medicine for Residue Symptoms of COVID-19 Recovered Patients- A Double-blind, Randomized, Placebo-controlled Study | UNKNOWN | PHASE2 | Chinese University of Hong Kong | The Change of Fatigue Severity Score | Long Term Symptom Assessment; The Change of Fatigue Severity Score (FSS); Improvement of dyspnoea using modified British Medical Research Council (mMRC) dyspnoea scale; The change of EuroQol five-dimension five-level (EQ-5D-5L)5L) questionnaire and it's V |
| NCT04482595 | A Phase 2 Study of BIO 300 Oral Suspension in Discharged COVID-19 Patients | UNKNOWN | PHASE2 | Humanetics Corporation | Change in DLCO | Change in 6 Minute Walk Test; Change in FVC; Change in St. George's Respiratory Questionnaire (SGRQ) Scores; Change in Pulmonary Fibrosis on HRCT Scan; Incidence of Re-Hospitalization; All-Cause Mortality; Change in FEV1; Change in FEV1/FVC Ratio; Change |
| NCT06004362 | Complementary and Integrative Medicine as an Online Intervention in Patients With Post-covid Syndrome - a Randomized-controlled Mixed-methods Trial. | UNKNOWN | nan | Charite University, Berlin, Germany | Short Form 36 (SF-36), Physical Functioning Scale | Short Form 36 (SF-36); DePaul Post-Exertional Malaise Questionnaire (DSQ-PEM); Post-COVID-Syndrom (PCS) Score; Chalder Fatigue Scale (CFS); Quality of life (EQ-5D-5L); General Self-Efficacy Scale (GSE, German version: ASKU); Visual analog scale (VAS) physical |
| NCT06145867 | A Feasibility Study Assessing the Acceptability, Adherence, and Safety of Photobiomodulation (PBM) Therapy and Objective Assessment Measures in Myalgic Encephalomyelitis (ME) | UNKNOWN | nan | Quadram Institute Bioscience | Compliance of PBM therapy in ME patients.; Acceptance of PBM therapy in ME patients.; Safety of PBM therapy in ME patients. | Compliance of the GENEActiv accelerometers in ME patients; Acceptance of the GENEActiv accelerometers in ME patients; Safety of GENEActiv accelerometers in ME patients.; Changes in NeurOn (online cognitive function assessments) completion rates in ME patients. |
| NCT06018649 | The Effectiveness and Safety of Using Lithuania's Natural Resources to Improve Stress-related Mental and Physical Health | UNKNOWN | nan | Klaipėda University | General Symptom Distress Scale (GSDS); PSS-10 (Perceived Stress Scale); Cortisol level in saliva | Anxiety by STAI-5- Spielberger State-Trait Anxiety Inventory; Work and social adjustment by WSAS (work and social adjustment scale); The safety of balneotherapy; Effect on depression- CESD-R (Center for Epidemiological Studies Depression Scale ); Effect on fat |
| NCT ID | Title | Status | Phase | Sponsor | Primary endpoint | Secondary endpoint |
|---|---|---|---|---|---|---|
| NCT05965726 | RECOVER-VITAL: A Platform Protocol for Evaluation of Interventions for Viral Persistence, Viral Reactivation, and Immune Dysregulation in Post-Acute Sequelae of SARS-CoV-2 Infectio | COMPLETED | PHASE2 | Kanecia Obie Zimmerman | Percentage of Participants Who Improved in Cognitive Dysfunction Symptom Cluster, as Measured by Patient-Reported Outcomes Measurement Information System (PROMIS) Cognitive 8a Function T-score; Percentage of Participants Who Improved in Autonomic Dysfunction S | Percentage of Participants Who Improved in Cognitive Dysfunction Symptom Cluster, as Measured by a Neurocognitive Battery; Percentage of Participants Who Improved in Autonomic Dysfunction Symptom Cluster, as Measured by the Active Stand Test; Percentage of Par |
| NCT06268288 | Pilot Study--The Effects of Non-invasive Vagal Neurostimulation (nVNS) in Adolescents With Postural Orthostatic Tachycardia Syndrome (POTS) | COMPLETED | nan | Mayo Clinic | The Change in Composite Autonomic Symptom Score (COMPASS-31); The Change in Child Functional Disability Inventory Scores; The Change in Heart Rate (Beats Per Minute) in Head up Tilt Table Tests | Change in the Number of Headaches Experienced by Adolescent Patients With POTS; Change in Exercise Duration (Minutes) in Adolescent Patients With POTS; Change in PHQ-9 Scores in Adolescent Patients With POTS |
| NCT06524739 | Double-blind, Randomized, Placebo-controlled Phase 3 Study Evaluating Efficacy and Safety of IgPro20 (Subcutaneous Immunoglobulin, HIZENTRA®) in Post-COVID-19 Postural Orthostatic | TERMINATED | PHASE3 | CSL Behring | Proportion of Participants No Longer Meeting Diagnostic Criteria of Post-COVID POTS as Measured by Standardized Standing Test (ie, No Longer Experiencing HR Increase of ≥30 Bpm, in the Absence of 20 mmHg Decrease of SBP [Orthostatic Hypotension]) | Change From Baseline in Orthostatic Intolerance (OI) Score of Composite Autonomic Symptom Score 31 (COMPASS-31); Change From Baseline in COMPASS-31 Total Score; Change From Baseline in Heart Rate Increase Within 10 Minutes of Standing Test; Number of Participa |
| NCT06305806 | RECOVER-AUTONOMIC (Ivabradine): Randomized Trial of the Effect of Ivabradine Versus Placebo on Long COVID Symptoms | COMPLETED | PHASE2 | Kanecia Obie Zimmerman | Change in Orthostatic Hypotension Questionnaire (OHQ)/Orthostatic Intolerance Questionnaire (OIQ) Composite Score | Change in Composite Autonomic Symptoms Score 31 (COMPASS-31); Change in Malmo POTS Symptom Score; Change in heart rate (HR); Change in 6-min Walk Test; Change in PROMIS-29 + 2 Questionnaire; Characterize the safety and tolerability of study intervention for tr |
| NCT05196529 | Inspiratory Muscle Training in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) and COVID-19 Survivors | COMPLETED | nan | York University | Chemoreflex function; Clinical autonomic function; Vascular function; Cognitive function | Cardiorespiratory fitness; ME symptoms |
| NCT06305793 | RECOVER-AUTONOMIC (IVIG): Randomized Trial of the Effect of IVIG Versus Placebo on Long COVID Symptoms | ACTIVE_NOT_RECRUITING | PHASE2 | Kanecia Obie Zimmerman | Change in Orthostatic Hypotension Questionnaire (OHQ)/Orthostatic Intolerance Questionnaire (OIQ) Composite Score | Change in Composite Autonomic Symptoms Score 31 (COMPASS-31); Change in Malmo POTS Symptom Score; Change in Active Stand Test; Change in blood pressure; Change in heart rate (HR); Change in 6-min Walk Test; Change in Patient-Reported Outcomes Measurement Infor |
| NCT05566379 | Effects of a Mindfulness Intervention on Physical and Psychological Well-Being and Quality of Life in Patients With Post Acute Sequelae of SARS-CoV-2 Infection (PASC) Dysautonomia | COMPLETED | nan | University of California, Los Angeles | Change from baseline in the composite autonomic symptom score COMPASS-31 for autonomic symptoms; Change from baseline in Active Stand Test of hemodynamic symptom parameters, exercise tolerance.; Change from baseline of Six Minute Walk in hemodynamic parameters | Change from baseline in mean scores of PSS- Perceived Stress Scale.; Change from baseline in mean scores of GAD7- Generalized Anxiety Disorder; Change from baseline in mean scores of PHQ-8 - Depressive Symptoms; Change from baseline in mean scores of IES-R - e |
| NCT05507190 | Self-management of Post COVID-19 Syndrome Using Wearable Biometric Technology | COMPLETED | nan | University of Manitoba | Change in lung capacity; Change in dyspnea; Change in fatigue; Chronic fatigue syndrome; Health-related quality of life; Postural orthostatic hypotension; Exercise capacity | Symptoms change; Patient satisfaction with the study |
| NCT06933017 | Feasibility Study of the Augmented Two-Day 6-Minute Incremental Step Test and Causal Exploration Through a Directed Acyclic Graph and Structural Equation Model for Post-Exertional | COMPLETED | nan | Universitair Ziekenhuis Brussel | Difference in oxygen uptake at peak (VO2 peak) between day 1 and day 2 measured with the CPET compared to measured with the Calibre device; Difference in Rate of Perceived Exertion (RPE) measured with the CPET compared to measured with the Calibre device; Rest | Change from Day 1 to Day 2 in Oxygen Uptake at First Ventilatory Threshold (VO₂ in ml/min/kg) during experimental session 1 or 2 (CPET); Change from Day 1 to Day 2 in Oxygen uptake at peak (VO2 in ml/min/kg) during experimental session 1 and 2 (CPET & 6MIS |
| NCT07182578 | Programming Aquatic Therapy for POTS | COMPLETED | nan | California State University, Dominguez Hills | World Health Organization Quality of Life - Brief (WHOQOL-BREF); The DePaul Symptom Questionnaire (Short Form) (DSQ-SF); Composite Autonomic Symptom Score-31; Malmo POTS Scale (MAPS); ADLS, IADLS, and Vestibular Questionnaire; Active Stand Test; Single leg sta | The Stroop Test; Trail Making Test Parts A & B; Enrollment; Attrition Rate; Session attendance rate; Cost analysis; Health utilization changes; Satisfaction Analysis; Exercise self-efficacy; Goal Attainment Scaling; Beighton Score |
| NCT06128356 | Pilot Study of Dexmedetomidine Sublingual Film for the Ambulatory Treatment of Hyperadrenergic Autonomic Crisis in Patients With Familial Dysautonomia | ACTIVE_NOT_RECRUITING | PHASE2 | NYU Langone Health | Number of subjects screened per month; Number of subjects enrolled per month; Number of completed crises treated at home within the protocol; Number of subjects that underwent an autonomic crisis per month; Average duration of the study from visit 1 to the las | Length of time from autonomic crisis onset to the initiation of the video recording; Length of time from autonomic crisis onset to administration of the medication; Length of time from autonomic crisis onset to crisis resolution; Length of time it took to comp |
| NCT04943276 | A Novel Noninvasive Thermoregulatory Device for Postural Tachycardia | COMPLETED | nan | Stanford University | Change from baseline in Compass-31 survey at study endpoint; Change from baseline in Pittsburg Sleep Quality Index (PSQI) at study endpoint; Change from baseline in Insomnia Severity Scale Index (ISI) at study endpoint; Temperature Quality of life Questionnair | nan |
| NCT05764070 | Impact of Vagus Nerve Stimulation on Post-Aerobic Activity Recovery in Post Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Patients | COMPLETED | nan | Istanbul Medipol University Hospital | Visual Analogue Scale (VAS); Autonomic nervous system device (Polar H10); Lactate Analysis | nan |
| NCT07077278 | Effect of Low Sodium Oxybate (LXB) on Autonomic Symptom Burden in Idiopathic Hypersomnia Patients With Postural Tachycardia Syndrome: a Placebo-controlled, Double-blind, Randomized | NOT_YET_RECRUITING | PHASE4 | Stanford University | Overall COMPASS-31 Score as a measure of direct comparison between the two conditions across the two-week randomized withdrawal period. | nan |
| NCT05409651 | Phenotyping Mitochondrial and Immune Dysfunction in POTS With Targeted Clinical Intervention. | ACTIVE_NOT_RECRUITING | nan | University of California, San Diego | Conduct a pilot clinical trial with POTS patients to assess if TRE can improve Quality of Life. | nan |
| NCT06148311 | Dexmedetomidine Sublingual Film for the Ambulatory Treatment of Hyperadrenergic Autonomic Crisis in Patients With Familial Dysautonomia | ENROLLING_BY_INVITATION | PHASE2 | NYU Langone Health | Percentage of patients with reduction of Autonomic crisis severity assessment scores (ACSAS) to ≤ 5 points; Percentage of patients with 25% reduction in blood pressure; Percentage of patients with >20% reduction in heart rate; Percentage of patients with &g | Percentage of patients with ≥ 20% reduction in hospitalizations; Percentage of patients with ≥ 20% reduction in hospital stay duration; Percentage of patients with ≥ 30% reduction in ICU stay duration; Change in number of medical complications |
| NCT05375968 | Mechanism of Glucose-dependent Insulinotropic Polypeptide (GIP) on Splanchnic Venous Capacitance in Postural Tachycardia Syndrome | RECRUITING | PHASE2 | Vanderbilt University Medical Center | Change in splanchnic venous capacitance in Postural Orthostatic Tachycardia Syndrome; Effect of glucose-induced GIP secretion on splanchnic venous capacitance; Effect of glucose-induced GIP secretion on POTS postprandial symptoms. | Measure Glucose-dependent Insulinotropic polypeptide (GIP) hormone level in POTS patients and Controls after 75 grams of glucose ingestion |
| NCT04140721 | Autonomic Determinants of Postural Tachycardia Syndrome (Chronic Pilot Study 2) | ACTIVE_NOT_RECRUITING | EARLY_PHASE1 | Vanderbilt University Medical Center | Change in Orthostatic Symptom Burden [delta (delta VOSS)] | Change in Orthostatic Change in Heart Rate [delta (delta HR)] |
| NCT07197905 | Restoring Iron Deficiency to Expand Blood Volume and Improve POTS | RECRUITING | PHASE2 | Vanderbilt University Medical Center | Orthostatic tachycardia | nan |
| NCT06936319 | Physical Counterpressure Maneuvers in Postural Orthostatic Tachycardia Syndrome (POTS) - a Monocentric, Randomized Controlled Trial | RECRUITING | nan | Medical University Innsbruck | Malmö Postural Orthostatic Tachycardia Syndrome symptom score (MAPS) | Severity of orthostatic intolerance (on a 0 - 10 points scale); Absolute heart rate; Absolute systolic and diastolic blood pressure; Supine-to-standing change in heart rate; Supine-to-standing change in systolic and diastolic blood pressure; Single items of th |
| NCT06170645 | Transcutaneous Vagus Nerve Stimulation as a Complementary Therapy to Exercise in Chronic Fatigue: Single-center, Controlled, Randomized, Blinded Study | RECRUITING | nan | Centre Hospitalier Universitaire de Saint Etienne | Fatigue evaluation assessed by autonomic nervous system activity | Fatigue Severity Scale (FSS); Medical Outcome Study Short Form questionnaire (MOS-SF 12); Pittsburgh questionnaire; 6-minute walk test (6MWT); Adult Physical Activity Questionnaire (APAQ); Step count per day; Ratio of Low Frequency to High Frequency (LF/HF) |
| NCT03365414 | A Double Blind Randomized Controlled Crossover Study to Systematically Assess the Efficacy and Safety of Intravenous Albumin Infusions in Severe Postural Orthostatic Tachycardia Sy | WITHDRAWN | PHASE3 | University of Alberta | Severity of Orthostatic Intolerance | Disability Assessment; Degree of cardiovascular improvement - Heart rate; Degree of cardiovascular improvement - Pulse; Change in maximal exercise capacity - Cardiopulmonary exercise testing; Change in maximal exercise capacity - Electrocardiogram; Change in m |
| NCT05554107 | The Effect of Physical Activity on Postural Orthostatic Tachycardia Syndrome | RECRUITING | nan | Lund University | POTS questionnaire | Orthostatic hypotension questionnaire; SF-36; Orthostatic tests; Maximal biking exercise |
| NCT07579026 | Effects of Breathing Retraining Exercises on Heartrate, Blood Pressure and Orthostatic Intolerance in Pregnant Females With Postural Orthostatic Tachycardia Syndrome. | RECRUITING | nan | Riphah International University | Vanderbilt Orthostatic symptom score; Non-invasive blood pressure measurement; Pulse oximetry | nan |
| NCT06292741 | Evaluation of the Prevalence of Autonomic Nervous System Involvement in Patients With Cognitive Impairment by a Non-invasive Combined Study of Dysautonomia | RECRUITING | nan | Fondazione Policlinico Universitario Agostino Gemelli IRCCS | evaluation of the prevalence in autonomic dysfunction in patients with MCI and dementia | correlation between the extent of autonomic involvement and the severity of cognitive decline; evaluation of the type of cognitive disorder, defined by the scores obtained in the MMSE between subjects with and without autonomic dysfunction. |
| NCT06996314 | Effects of Transcutaneous Auricular Vagus Nerve Stimulation Combined With Slow-Paced Diaphragmatic Breathing on Postural Tachycardia Syndrome: A Randomized Controlled Trial | NOT_YET_RECRUITING | nan | Ali Kapan | Change in Heart Rate From Supine to Standing (Delta HR) After 12 Weeks of Daily taVNS With or Without Slow-Paced Breathing in Individuals With POTS | nan |
| NCT07026643 | Auricular Vagal Neuromodulation Therapy in Postural Orthostatic Tachycardia Syndrome: Physiological Mechanisms and Systemic Effects - A Pilot Study | NOT_YET_RECRUITING | nan | University of Calgary | Chronic aVNT in POTS induces favorable autonomic neuromodulation and decreases orthostatic tachycardia; chronic aVNT in POTS induces favorable autonomic neuromodulation and decreases orthostatic tachycardia | nan |
| NCT07409363 | A Randomised, Single-blind, Sham-controlled, Crossover Pilot Study Assessing the Effect of Non-invasive Vagus Nerve Stimulation (nVNS) on Autonomic Symptoms and Pain Management in | NOT_YET_RECRUITING | nan | University of Leeds | Composite Autonomic Symptom Score-31 (COMPASS-31) total score | Positive overall response to the NASA Lean Test procedure; Maximum increase in heart rate during NASA Lean Test procedure; Brief Pain Inventory - Short Form (BPI-SF): Pain Severity Score; Brief Pain Inventory - Short Form (BPI-SF): Pain Interference Score; Hos |
| NCT04855266 | A Randomized, Controlled, Double-Blind, Placebo-Controlled Study Evaluating the Efficacy of Intravenous Iron Sucrose in Patients With Non-anemic Iron Deficiency and Postural Orthos | WITHDRAWN | PHASE2 | Mayo Clinic | Change in autonomic dysfunction symptoms; Change in postural heart rate increase | nan |
| NCT07312409 | Does Taurine Supplementation Improve Vascular Function and Orthostatic Responses in Long COVID? | NOT_YET_RECRUITING | nan | York University | Orthostatic responses; Vascular function | Heart rate variability |
| NCT07046208 | Effects os Physiotherapeutic Rehabilitation on Cardiovascular Autonomic Modulation and Biomarkers Inflammatory and Cardiac Conditions in Patients With Long Covid | NOT_YET_RECRUITING | nan | Universidade do Estado do Pará | Autonomic Modulation | Inflammation |
| NCT04702217 | Physical Activity as a Complementary Treatment in Postural Orthostatic Tachycardia Syndrome - Evaluation of a Structured Physical Activity Program in Clinical Practice | WITHDRAWN | nan | Lund University | POTS questionnaire | Orthostatic hypotension questionnaire; SF-36; Orthostatic tests; Submaximal biking exercise |
| NCT05923840 | Mechanism of Chemoreflex and Baroreflex Alterations Causing Postural Tachycardia Syndrome in POTS Patients With Orthostatic Hyperpnea and Hypocapnia | UNKNOWN | nan | New York Medical College | Orthostatic tachycardia; Orthostatic Blood Pressure Changes; Orthostatic Changes in Systemic Vascular Resistance; Orthostatic Blood Volume Changes; Orthostatic Changes in Segmental Blood Flow; Orthostatic Changes in Cerebral Blood Flow; Orthostasis Induced Rat | Systemic changes in leg blood volumes during orthostatic testing.; Systemic changes in abdominal blood volumes during orthostatic testing. |
| NCT ID | Title | Status | Phase | Sponsor | Primary endpoint | Secondary endpoint |
|---|---|---|---|---|---|---|
| NCT05576662 | Selective Trial Of Paxlovid for PASC (STOP-PASC): Randomized Double-Blind Placebo-Controlled Pilot Trial of Paxlovid for the Treatment of PASC | COMPLETED | PHASE2 | Stanford University | Number of Participants With No, Mild, Moderate, or Severe Symptoms at Week 10 According to the Core Symptoms Severity Scale Score | Number of Participants With No, Mild, Moderate, or Severe Symptoms at Day 15 According to the Core Symptoms Severity Scale Score; Number of Participants Reporting Relief of at Least One Core Symptom for 2 Weeks; Number of Participants With Overall Alleviation |
| NCT05965726 | RECOVER-VITAL: A Platform Protocol for Evaluation of Interventions for Viral Persistence, Viral Reactivation, and Immune Dysregulation in Post-Acute Sequelae of SARS-CoV-2 Infectio | COMPLETED | PHASE2 | Kanecia Obie Zimmerman | Percentage of Participants Who Improved in Cognitive Dysfunction Symptom Cluster, as Measured by Patient-Reported Outcomes Measurement Information System (PROMIS) Cognitive 8a Function T-score; Percentage of Participants Who Improved in Autonomic Dysfunction S | Percentage of Participants Who Improved in Cognitive Dysfunction Symptom Cluster, as Measured by a Neurocognitive Battery; Percentage of Participants Who Improved in Autonomic Dysfunction Symptom Cluster, as Measured by the Active Stand Test; Percentage of Par |
| NCT04977388 | Phase I/II Study of NORTHERA (DROXIDOPA) for Dysautonomia in Adult Survivors of Menkes Disease and Adults With Occipital Horn Syndrome: Double-blind Placebo-controlled Randomized C | COMPLETED | PHASE1; PHASE2 | Stephen G. Kaler, MD | Treatment Related Adverse Events as Assessed by CTCAE v4.0 | Mean Change in Systolic Blood Pressure in Tilt Position; Mean Change in Diastolic Blood Pressure in Tilt Position; Plasma Catechol Levels; Change From Baseline in Daily Bowel Movements; Change From Baseline in Time Standing Duration; Change From Baseline in Ti |
| NCT05877508 | An Exploratory, Randomized, Double-Blind Placebo-Controlled Study to Assess the Safety of an Anti-SARS-CoV-2 Monoclonal Antibody and Response to Treatment in Individuals With Long | ACTIVE_NOT_RECRUITING | PHASE2 | Michael Peluso, MD | Patient-Reported Outcomes Measurement Information System (PROMIS)-29 Physical Health Summary Score | Patient-Reported Outcomes Measurement Information System (PROMIS)-29 Physical Health Summary Score; Patient-Reported Outcomes Measurement Information System (PROMIS)-29 Mental Health Summary Score; Patient-Reported Outcomes Measurement Information System (PROM |
| NCT06161688 | Placebo-Controlled, Randomized Trial of Ensitrelvir (S-217622) for Viral Persistence and Inflammation in People Experiencing Long COVID (PREVAIL-LC) | ACTIVE_NOT_RECRUITING | PHASE2 | Timothy Henrich | Patient-Reported Outcomes Measurement Information System (PROMIS)-29 Physical Health Summary Score | Patient-Reported Outcomes Measurement Information System (PROMIS)-29 Physical Health Summary Score; Patient-Reported Outcomes Measurement Information System (PROMIS)-29 Mental Health Summary Score; Patient-Reported Outcomes Measurement Information System (PROM |
| NCT06268288 | Pilot Study--The Effects of Non-invasive Vagal Neurostimulation (nVNS) in Adolescents With Postural Orthostatic Tachycardia Syndrome (POTS) | COMPLETED | nan | Mayo Clinic | The Change in Composite Autonomic Symptom Score (COMPASS-31); The Change in Child Functional Disability Inventory Scores; The Change in Heart Rate (Beats Per Minute) in Head up Tilt Table Tests | Change in the Number of Headaches Experienced by Adolescent Patients With POTS; Change in Exercise Duration (Minutes) in Adolescent Patients With POTS; Change in PHQ-9 Scores in Adolescent Patients With POTS |
| NCT06208163 | Psychoneuroimmunology as a Framework for Studying the Effects of Chiropractic Care in a Population With High Central Adiposity: a Pilot Trial | COMPLETED | nan | Life University | Proportion of Potential Participants Who Are Eligible.; Proportion of Participants Complying With Pre-baseline Lifestyle Restrictions; Proportion of Participants Able to Tolerate the Assessments; Proportion of Participants Adhering to Their Prescribed Care Pla | Changes in COMPASS-31 Raw Scores; Changes in PSS-10 T-scores; Changes in PROMIS-Cog 8 T-scores; Changes in PROMIS-29 Subscale T-scores; Changes in PROMIS-29 Subscale Raw Scores; Changes in RMSSD; Changes in PEP; Changes in sIgA |
| NCT06524739 | Double-blind, Randomized, Placebo-controlled Phase 3 Study Evaluating Efficacy and Safety of IgPro20 (Subcutaneous Immunoglobulin, HIZENTRA®) in Post-COVID-19 Postural Orthostatic | TERMINATED | PHASE3 | CSL Behring | Proportion of Participants No Longer Meeting Diagnostic Criteria of Post-COVID POTS as Measured by Standardized Standing Test (ie, No Longer Experiencing HR Increase of ≥30 Bpm, in the Absence of 20 mmHg Decrease of SBP [Orthostatic Hypotension]) | Change From Baseline in Orthostatic Intolerance (OI) Score of Composite Autonomic Symptom Score 31 (COMPASS-31); Change From Baseline in COMPASS-31 Total Score; Change From Baseline in Heart Rate Increase Within 10 Minutes of Standing Test; Number of Participa |
| NCT05823896 | An Interventional, Double-Blinded, 2-Arm Study to Investigate the Efficacy of Orally Administered Nirmatrelvir/Ritonavir Compared with Placebo/Ritonavir in Non-hospitalized Adult P | COMPLETED | PHASE2 | Karolinska Institutet | Change from baseline in quality of life over time | Change from baseline in quality of life over time; Change from baseline in hemodynamic response over time; Change from baseline in dysautonomia over time; Change from baseline in fever in patients with POTS over time; Change from baseline in endothelial functi |
| NCT06305806 | RECOVER-AUTONOMIC (Ivabradine): Randomized Trial of the Effect of Ivabradine Versus Placebo on Long COVID Symptoms | COMPLETED | PHASE2 | Kanecia Obie Zimmerman | Change in Orthostatic Hypotension Questionnaire (OHQ)/Orthostatic Intolerance Questionnaire (OIQ) Composite Score | Change in Composite Autonomic Symptoms Score 31 (COMPASS-31); Change in Malmo POTS Symptom Score; Change in heart rate (HR); Change in 6-min Walk Test; Change in PROMIS-29 + 2 Questionnaire; Characterize the safety and tolerability of study intervention for tr |
| NCT05638620 | Evaluating the Effectiveness of Dual Sympathetic Blocks for Patients Experiencing Sympathetically-Mediated Symptoms From Post-Acute Sequelae of SARS-CoV-2 (PASC) | COMPLETED | PHASE1 | Jonathann Kuo, MD | Patient-Reported Outcomes: PROMIS-29 Score; Depression; Anxiety; Physical function; Pain interference; Fatigue; Sleep disturbance; Ability to participate in social roles and activities status | Autonomic Symptoms: COMPASS-31 Score |
| NCT06404073 | RECOVER-ENERGIZE: A Platform Protocol for Evaluation of Interventions for Exercise Intolerance in Post-Acute Sequelae of SARS-CoV-2 Infection (PASC) | COMPLETED | nan | Duke University | Change in frequency of PEM symptoms, as measured by the Modified DePaul Symptom - Post-Exertional Malaise questionnaire (mDSQ-PEM); Change in severity of PEM symptoms, as measured by the Modified DePaul Symptom - Post-Exertional Malaise questionnaire (mDSQ-PEM | Change in PASC symptoms, as measured by the PASC Symptom Questionnaire; Change in PASC symptoms, as measured by the PROMIS-Cog Questionnaire; Change in quality of life, as measured by the PROMIS-29+2; Change in quality of life, as measured by the EQ-5D 5L; Cha |
| NCT05710770 | Double-blinded, Randomized, Sham-controlled Trial of Immunoadsorption (IA) in Patients With Chronic Fatigue Syndrome (CFS) Including Patients With Post-acute COVID-19 CFS (PACS-CFS | COMPLETED | nan | Charite University, Berlin, Germany | Improvement in physical and mental fatigue as measured by the Chalder Fatigue Scale | Sustained improvement quantified by the Chalder Fatigue Scale; Verification of safety and tolerability of immunoadsorption in this patient population; Improvement in severity of symptoms of chronic fatigue syndrome (CFS) as measured by the Fluge score; Improve |
| NCT07280572 | RECLAIM: an Adaptive Platform Trial for the Evaluation of Treatments for Post-Acute Sequelae of SARS-CoV-2 Infection (PASC) | ENROLLING_BY_INVITATION | PHASE3 | Janneke van de Wijgert | Physical health-related quality of life (HRQoL) | Mental HRQoL; Other aspects of HRQoL; Fatigue; Post Exertional Malaise (PEM); Cognitive functioning; Post Orthostatic Tachycardia Syndrome (POTS); Safety of IPs; Tolerability of IPs; Durability of IP treatment responses |
| NCT05697640 | A Parallel-group Treatment, Phase 2a, Double-blind, Placebo-controlled 2-arm Study to Show Improvement of Physical Function in SF-36 (SF-36-PF) in Participants Treated With Vericig | ACTIVE_NOT_RECRUITING | PHASE2 | Charite University, Berlin, Germany | Improvement in Physical Function (PF) as measured by the Short Form 36 Health Survey Questionnaire (SF-36) | Difference in responder rate in Physical Function (PF) as measured by the Short Form 36 Health Survey Questionnaire (SF-36) comparing Vericiguat with placebo; Improvement in other sub-domains of the Short Form 36 Health Survey Questionnaire (SF-36) comparing V |
| NCT04603157 | Remote Self-training Program for Patients With Postural Orthostatic Tachycardia Syndrome (POTS) | COMPLETED | nan | Mayo Clinic | Change Peak Oxygen consumption at 3 months | Change in Composite Autonomic Symptom Score (COMPASS 31) at 3 months; Change in Functional Ability Score at 3 months; Change in 36-Item Short Form Health Survey questionnaire (SF-36) at 3 months; Change in heart rate with 10-min Stand test at 3 months; Change |
| NCT06305793 | RECOVER-AUTONOMIC (IVIG): Randomized Trial of the Effect of IVIG Versus Placebo on Long COVID Symptoms | ACTIVE_NOT_RECRUITING | PHASE2 | Kanecia Obie Zimmerman | Change in Orthostatic Hypotension Questionnaire (OHQ)/Orthostatic Intolerance Questionnaire (OIQ) Composite Score | Change in Composite Autonomic Symptoms Score 31 (COMPASS-31); Change in Malmo POTS Symptom Score; Change in Active Stand Test; Change in blood pressure; Change in heart rate (HR); Change in 6-min Walk Test; Change in Patient-Reported Outcomes Measurement Infor |
| NCT06960928 | Low Dose Sirolimus in People With Post-Acute Sequelae of COVID-19 (PASC) Long COVID-19 | RECRUITING | PHASE3 | Icahn School of Medicine at Mount Sinai | European Quality of Life-Visual Analogue Scale (EQ-VAS) | The EuroQol Five-Dimensional Health Questionnaire (EQ-5D-5L); Patient-Reported Outcomes Measurement Information System 29 (PROMIS-29); General Symptom Questionnaire (GSQ-30); Patient Health Questionnaire (PHQ-9); Generalized Anxiety Disorder (GAD-7); Neuro-QoL |
| NCT05664711 | Effect of Stellate Ganglion Block on ME/CFS Symptoms and Metabolites | COMPLETED | PHASE1 | Neuroversion, Inc. | Change in Subjective Rating of Symptoms at 2 Weeks; Change in Subjective Rating of Symptoms at 2 Months; Change in Cognitive Function at 2 Weeks; Change in Cognitive Function at 2 Months | Change in Orthostatic Tolerance at 2 Weeks; Change in Orthostatic Tolerance at 2 Months; Change in Autonomic Tone at 2 Weeks; Change in Autonomic Tone at 2 Months |
| NCT06503913 | Cognitive Muscular Therapy for Patients With Long-COVID (Post COVID-19) and Breathing Pattern Disorder | COMPLETED | nan | University of Salford | Change in Nijmegen Questionnaire | Change in Modified COVID-19 Yorkshire Rehabilitation Scale (C19-YRSm) scale; Change in Dyspnea-12 questionnaire; Change in Self-evaluation of breathing questionnaire; Change in Composite Autonomic Symptom Score; Change in EQ-5D-5L; Change in WHO Disability Ass |
| NCT06172803 | RESToRE: Restoring Energy With Sub-symptom Threshold Optimized Rehabilitation Exercise for Long COVID | COMPLETED | nan | Columbia University | Number of participants who enrolled; Number of participants who completed; Number of participants who adhered to session attendance | PROMIS-29 scale score; Rand 36-Item Health Survey (SF-36) score; VO2 % predicted from Cardiopulmonary Exercise Testing (CPET); Number of participants with orthostatic hypocapnia.; EuroQol: Education Quotient-5D Visual Analogue Scale score; General Symptom Ques |
| NCT05954325 | Extracorporal Apheresis Hannover Medical School Study in Post COVID-19 Patients | COMPLETED | nan | Hannover Medical School | Chalder Fatigue Scale | Cognitive Function; Post exertional malaise symptoms; Measure of health status; Depression and Anxiety; Autonomic dysfunction; 6-min. walk test; Hand grip strength; Optical coherence tomography angiography; Cranial magnetic resonance imaging and spectroscopy; |
| NCT06017232 | The ParkinSANTÉlé Study: A Multicomponent Telerehabilitation Program to Improve Cardiovascular Health in People With Parkinson's Disease With a Clinical Diagnosis of Dysautono | COMPLETED | nan | Université de Sherbrooke | Feasibility of the implementation; Acceptability; Dysautonomia Symptoms; Impact of dysautonomia symptoms; Exercise capacity | Severity of pain and impact on functioning; Type of pain; Perceived quality of life; Lower-limb function; Mobility in the community; Mobility; Balance; Walking capacity; Lower-limb strength and power; Cardiovascular health; Sympathetic nervous innervation of t |
| NCT06631287 | Randomized Double-Blind Placebo-Controlled Trial EValuating Baricitinib on PERSistent NEurologic and Cardiopulmonary Symptoms of Long COVID (REVERSE-LC) | RECRUITING | PHASE3 | Wes Ely | CNS-Vital Signs Global Cognitive Index | Objective neuropsychological function domains of executive function, memory, processing speed, and motor speed including the CNS-Vital Signs subscale tests at 6-months.; Objective neuropsychological function domains of executive function, memory, processing sp |
| NCT06128356 | Pilot Study of Dexmedetomidine Sublingual Film for the Ambulatory Treatment of Hyperadrenergic Autonomic Crisis in Patients With Familial Dysautonomia | ACTIVE_NOT_RECRUITING | PHASE2 | NYU Langone Health | Number of subjects screened per month; Number of subjects enrolled per month; Number of completed crises treated at home within the protocol; Number of subjects that underwent an autonomic crisis per month; Average duration of the study from visit 1 to the las | Length of time from autonomic crisis onset to the initiation of the video recording; Length of time from autonomic crisis onset to administration of the medication; Length of time from autonomic crisis onset to crisis resolution; Length of time it took to comp |
| NCT07359482 | sElective Serotonin reuPtake inhibitoRs In posT-covid: ESPRIT | NOT_YET_RECRUITING | PHASE3 | Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) | Fatigue severity | Fatigue severity; Cognitive functioning; Cognitive functioning; PEM; POTS (National Aeronautics and Space Administration (NASA) lean test; POTS; Health-related Quality of Life; Disability; Side effects; Side effects; Brain Perfusion (optional MRI substudy); Br |
| NCT06391489 | Piloting A Telehealth Deliverable Self-Management and Cognitive Training Program (HOBSCOTCH, HOme Based Self-Management and COgnitive Training CHanges Lives) for People With Post A | ACTIVE_NOT_RECRUITING | nan | Dartmouth-Hitchcock Medical Center | Change in overall quality of life as measured by comparing PROMIS-10 Global Health scores pre- and post-HOBSCOTCH-PACS intervention.; Change in subjective cognition as measured by comparing Neuro-QOL Item Bank v2.0 Cognitive Function scores pre- and post-HOBSC | Change in objective cognition as measured by comparing Symbol-Digit Modalities Test scores pre- and post-HOBSCOTCH-PACS intervention.; Change in objective cognition as measured by comparing California Verbal Learning Test-III scores pre- and post-HOBSCOTCH-PAC |
| NCT06974084 | A Multi-Center Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy of Maraviroc and Atorvastatin for the Treatment of Subjects With Long COVID/Post-Acute Se | NOT_YET_RECRUITING | PHASE2; PHASE3 | HealthBio, Inc. | Fatigue | Improvement in dysautonomia symptoms as reflected by the Composite Autonomic Symptom Score (COMPASS-31); Improvement in Dyspnea; Improved Cognitive Function, measured by the PROMIS (Patient-Reported Outcomes Measurement Information System) Cognitive Function v |
| NCT04186286 | A Randomized Crossover Study of Propranolol Versus Ivabradine in Postural Tachycardia Syndrome (POTS) | RECRUITING | PHASE2 | University of Calgary | Change in HR | Vanderbilt Orthostatic Symptoms Score |
| NCT06511063 | Investigating the Feasibility of Repurposing HIV Antivirals in Adults With Long Covid | RECRUITING | PHASE2 | Icahn School of Medicine at Mount Sinai | EuroQol 5-Dimension 5-Level (EQ-5D-5L) Visual Analogue Scale | The EuroQol Five-Dimensional Health Questionnaire (EQ-5D-5L); Patient-Reported Outcomes Measurement Information System 29 (PROMIS-29); General Symptom Questionnaire (GSQ-30); Patient Health Questionnaire (PHQ-9); Generalized Anxiety Disorder (GAD-7); Neuro-QoL |
| NCT06952413 | An Exploratory, Placebo-controlled, Double-blind, Phase II Study of the Efficacy and Safety for Rituximab (Genetical Recombination) in Myalgia Encephalomyelitis/Chronic Fatigue Syn | RECRUITING | PHASE2 | National Center of Neurology and Psychiatry, Japan | Improvement rate | Percentage of patients whose MHLW-PS-based ME/CFS severity score improved by 1 or more at each evaluation point (improvement rate) compared to that before the start of treatment with the investigational drug (week 0).; The amount of change in the severity scor |
| NCT06968104 | Stimulation of the Transcutaneous Auricular Vagus Nerve for Improvement of Symptoms in Patients With Post-COVID Syndrome and ME/CFS | ACTIVE_NOT_RECRUITING | nan | University of Luxembourg | Fatigue | Patient Health (Quality of life); Patient Health (Ability); Post-Exertional Malaise (PEM); Autonomic Function; Sleep Quality; Sleepiness; Depression and Anxiety; Patients Activity |
| NCT05375968 | Mechanism of Glucose-dependent Insulinotropic Polypeptide (GIP) on Splanchnic Venous Capacitance in Postural Tachycardia Syndrome | RECRUITING | PHASE2 | Vanderbilt University Medical Center | Change in splanchnic venous capacitance in Postural Orthostatic Tachycardia Syndrome; Effect of glucose-induced GIP secretion on splanchnic venous capacitance; Effect of glucose-induced GIP secretion on POTS postprandial symptoms. | Measure Glucose-dependent Insulinotropic polypeptide (GIP) hormone level in POTS patients and Controls after 75 grams of glucose ingestion |
| NCT05094622 | Physical Exercise in Patients With Postural Orthostatic Tachycardia Syndrome (POTS) After Covid-19. | ACTIVE_NOT_RECRUITING | nan | Karolinska Institutet | Change in Health-Related Quality of Life (HRQoL); Change in time in upright position and steps per day | Change in walking distance during 6 minute walk test; Change in oxygen saturation during 6 minute walk test; Change in oxygen desaturation during 6 minute walk test; Change in dyspnea during 6 minute walk test; Change in leg fatigue during 6 minute walk test; |
| NCT04140721 | Autonomic Determinants of Postural Tachycardia Syndrome (Chronic Pilot Study 2) | ACTIVE_NOT_RECRUITING | EARLY_PHASE1 | Vanderbilt University Medical Center | Change in Orthostatic Symptom Burden [delta (delta VOSS)] | Change in Orthostatic Change in Heart Rate [delta (delta HR)] |
| NCT07316127 | A Placebo-Controlled, Double-Blind, Randomized Trial Phase I-II With Immunoadsorption in Autoimmune Long COVID | RECRUITING | PHASE2 | Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) | Change in fatigue measured by the Fatigue Assessment Scale (FAS) | Change in health related quality of life using the 36-Item Short Form Health Survey (SF-36); Change in cognitive functioning using the Patient-Reported Outcomes Measurement Information System (PROMIS®) Cognitive Function Short Form 8a (PROMIS Cognitive Functio |
| NCT07189936 | Mechanism of Isolevuglandin-Protein Adduct Formation in Persistent Immune Activation in Long COVID POTS | RECRUITING | PHASE2 | Vanderbilt University Medical Center | Effect IsoLG-adducts (2-HOBA) measured by levels of monocyte/T cell doublets in LCPOTS.; Changes in Splanchnic venous capacitance before and after 28 days of treatment | Measure the effects of 2- HOBA on Orthostatic Tachycardia at HUT |
| NCT07021794 | Effectiveness of Treating Post-COVID-19 Conditions (Long COVID) With the SARS-CoV-2 Specific Monoclonal Antibody, Sipavibart | RECRUITING | PHASE2 | Nancy Klimas | Patient-Reported Outcomes Measurement Information System-29; Review of Treatment Related Adverse Events | Symptom-specific participant-reported outcome measures; Change in Simple Reaction Time (Milliseconds); Self-reported fatigue using MFI; Change in Heart Rate Post-6MWT; Processing Speed; Attention; Systolic Blood Pressure Response During NASA Lean Test; Diastol |
| NCT07374562 | Effect of Stellate Ganglion Block Treatment on Long COVID Symptoms: A Single-Blind, Single-Center Randomized Controlled Trial (STAR-CO) | RECRUITING | nan | Centre intégré universitaire de santé et de services sociaux de la Mauricie-et-du-Centre-du-Québec | Post-COVID-19 Functional Status Scale (PCFS); Fatigue Severity Scale (FSS); Brain Fog Scale (BFS) | Health-Related Quality of Life (SF-36); Dyspnea Severity (mMRC Scale); Lower-Limb Muscle Endurance (1-Minute Sit-to-Stand Test); Orthostatic Intolerance (NASA Lean Test) |
| NCT06168006 | Effects of a Physical Training Program Using a Mobile App on the Functionality and Cardiovascular Function of Individuals With Post-covid-19 Syndrome: Randomized Clinical Trial | RECRUITING | nan | University of Nove de Julho | Change from baseline in 6 min-walk test distance at 12 weeks; Change from baseline in Glittre test at 12 weeks; Change from baseline in sit and stand test at 12 weeks; Change from baseline in Post-Covid Functional Scale at 12 weeks | Change from baseline in Patient Functional Scale at 12 weeks; Change from baseline in Motor Evoked Potential at 12 weeks; Change from baseline in Modified Medical Research Dyspnea Scale at 12 weeks; Change from baseline in Chalder Physical Fatigue Scale at 12 |
| NCT06936319 | Physical Counterpressure Maneuvers in Postural Orthostatic Tachycardia Syndrome (POTS) - a Monocentric, Randomized Controlled Trial | RECRUITING | nan | Medical University Innsbruck | Malmö Postural Orthostatic Tachycardia Syndrome symptom score (MAPS) | Severity of orthostatic intolerance (on a 0 - 10 points scale); Absolute heart rate; Absolute systolic and diastolic blood pressure; Supine-to-standing change in heart rate; Supine-to-standing change in systolic and diastolic blood pressure; Single items of th |
| NCT07089719 | Bevacizumab in Post-acute Sequelae of COVID-19 : Efficacy and Safety (Pilot Study) | NOT_YET_RECRUITING | PHASE2 | Assistance Publique - Hôpitaux de Paris | Rate of patients with 10% increase of impaired DLCO | Proportion of patients with recovery of clinical symptoms; Proportion of patients with recovery of psychological, cognitive, and autonomic functions; Proportion of patients with improvement of other parameter than DLCO explored by Pulmonary Function Test; Modi |
| NCT07585513 | A Randomized Placebo-Controlled Clinical Trial Evaluating Mirabegron's Effectiveness in Alleviating POTS Symptoms | NOT_YET_RECRUITING | PHASE2 | Cedars-Sinai Medical Center | Self-reported frequencies of cardiac-related symptoms as recorded by the number of pushbutton events per day on the monitor. | Malmö POTS Symptom Score; EQ-5D-5L quality of life score; Duke Activity Status Index; Seattle Angina Questionnaire score; OAB-q SF; PROMIS survey; skin sympathetic nerve activity (SKNA) parameters |
| NCT05554107 | The Effect of Physical Activity on Postural Orthostatic Tachycardia Syndrome | RECRUITING | nan | Lund University | POTS questionnaire | Orthostatic hypotension questionnaire; SF-36; Orthostatic tests; Maximal biking exercise |
| NCT06419959 | Improving Cardiovascular Health in Veterans With PTSD by Treating Trauma-Related Nightmares With NightWare | RECRUITING | nan | VA Office of Research and Development | Change in Pittsburgh Sleep Quality Index | Change in physiological sleep - total sleep time; Change in endothelial function; Change in Autonomic function - spontaneous baroreflex sensitivity (BRS); Change in large elastic artery stiffness; Change in large elastic artery stiffness; Change in autonomic f |
| NCT05924646 | CAlgary SAlt for Postural Orthostatic Tachycardia Syndrome Study | RECRUITING | nan | University of Calgary | Upright Heart Rate | Vanderbilt Orthostatic Symptom Score (VOSS); Systolic Blood Pressure; Diastolic Blood Pressure; Stroke volume |
| NCT05421208 | Cardiovascular Autonomic and Immune Mechanism of Post COVID-19 Tachycardia Syndrome | RECRUITING | nan | Vanderbilt University Medical Center | IL-6 levels | Orthostatic Symptoms Score |
| NCT07278206 | Mitigating Cognitive Problems and Fatigue With Brain Stimulation in Long COVID | RECRUITING | nan | Amsterdam UMC, location VUmc | Fatigue | Objective cognitive functioning; Arterial Spin Labeling (ASL); Magnetic Resonance Spectroscopy (MRS); Functional Magnetic Resonance Imaging (fMRI); Actigraphy; Short physical performance battery (SPPB); Simple Reaction Time (SRT); Effort-based decision task; N |
| NCT07110714 | Effects of Kneipp Hydrotherapy in Post-COVID-19 Patients: A Randomized Controlled Trial | RECRUITING | nan | Eggensberger OHG | Health-related quality of life by Short Form-12 Health Survey (SF-12) | Fatigue severity by Fatigue Severity Scale; Sleep quality by Pittsburgh Sleep Quality Index; Health status by EuroQol-5 Dimensions-5 Levels; Autonomic function (heart rate variability by photoplethysmography); Resting blood pressure (systolic and diastolic); P |
| NCT05877534 | Effects of Individual Tailored Physical Exercise in Patients With Post COVID-19 Condition, Diagnosed With Postural Orthostatic Tachycardia Syndrome (POTS) - a Randomized Controlled | ENROLLING_BY_INVITATION | nan | Karolinska Institutet | Change in time in upright position and steps per day; Change in Health-Related Quality of Life (HRQoL) | Change in walking distance during 6 minute walk test; Change in oxygen saturation during 6 minute walk test; Change in dyspnea during 6 minute walk test; Change in leg fatigue during 6 minute walk test; Change in exertion during 6 minute walk test; Change in h |
| NCT05748015 | Definition of Autonomic Nervous System Involvement in Patients With Relapsing-remitting and Primary Progressive Multiple Sclerosis | RECRUITING | nan | Istituti Clinici Scientifici Maugeri SpA | Cardiovascular reflex test; Sudomotor function test | Quantification of peripheral autonomic nerve fibers; Quantification of peripheral sensory nerve fibers |
| NCT05566483 | Physiological Underpinnings of Post-Acute Sequelae of SARS CoV-2 ("Long COVID") and Impact of Cardiopulmonary Rehabilitation on Quality-of-Life and Functional Capacity | RECRUITING | nan | University of Colorado, Denver | Characterizing the impact of exercise training (cardiac rehabilitation) on functional capacity among patients with Long COVID; Characterizing the impact of exercise training (cardiac rehabilitation) on HRqOL among patients with Long COVID | orthostatic challenge |
| NCT05530317 | CArdiac REhabilitation for Building Exertional heArt Rate for Chronotropic Incompetence in Long COVID-19 (CARE BEAR-LC): A Proof-of-Concept, Mechanistic Trial | RECRUITING | nan | University of California, San Francisco | Change in adjusted heart rate reserve; Change in Peak VO2 (ml/kg/min) | Change in Peak VO2 (percent predicted); Number of Cardiac Rehabilitation sessions attended; Change in Proportion with peak VO2 less than 85% predicted; Change in Number of Long COVID symptoms; Change in Composite Autonomic Symptom Scale-31 (Compass 31) Score; |
| NCT05633693 | Impact of Postural Sway on Cardiovascular Control in Pediatric Patients With Syncope | RECRUITING | nan | Simon Fraser University | Relationship between postural movement and stroke volume | Relationship between anthropometry and response magnitude; Relationship between tanner stage and response magnitude; Relationship between autonomic control and response magnitude |
| NCT06292741 | Evaluation of the Prevalence of Autonomic Nervous System Involvement in Patients With Cognitive Impairment by a Non-invasive Combined Study of Dysautonomia | RECRUITING | nan | Fondazione Policlinico Universitario Agostino Gemelli IRCCS | evaluation of the prevalence in autonomic dysfunction in patients with MCI and dementia | correlation between the extent of autonomic involvement and the severity of cognitive decline; evaluation of the type of cognitive disorder, defined by the scores obtained in the MMSE between subjects with and without autonomic dysfunction. |
| NCT07013903 | Effects of Kneipp Hydrotherapy During Inpatient Post-Covid-19 Rehabilitation: A Randomized Controlled Trial | RECRUITING | nan | Schön Klinik Berchtesgadener Land | Health-related quality of life by Short Form-12 Health Survey (SF-12) | Fatigue severity by Fatigue Severity Scale; Sleep quality by Pittsburgh Sleep Quality Index; Health status by EuroQol-5 Dimensions-5 Levels; Autonomic function (heart rate variability by photoplethysmography); Resting blood pressure (systolic and diastolic); P |
| NCT06027255 | Long COVID Immune Profiling | RECRUITING | nan | Vanderbilt University Medical Center | IL-6 levels | Orthostatic Symptoms Score; cytokines (IL-17, and IFN-ɣ) |
| NCT05931497 | A Pilot Study of Whole Body Hyperthermia for Long Covid or Post-Acute Sequelae of COVID-19 (PASC) | RECRUITING | nan | Massachusetts General Hospital | The Patient Reported Outcome Measurement Information System Fatigue-Short Form v1.0 -Fatigue 7a (PROMIS F-SF) | Patient-Reported Outcomes Measurement Information System (PROMIS-29); Patient Health Questionnaire-9 (PHQ); The Perceived Stress Scale (PSS); Patient-Reported Outcomes Measurement Information System Cognitive Abilities; Patient-Reported Outcomes Measurement In |
| NCT06953661 | Ultrasound Guided Stellate Ganglion Block in Postural Tachycardia Syndrome: A Randomized Double Blind Sham Placebo-controlled Pilot Study | NOT_YET_RECRUITING | nan | Stanford University | COMPASS 31 total score | Magnitude of postural tachycardia; Heart rate variability (HRV); Plasma catecholamine levels; Survey of Postural Orthostatic Tachycardia Syndrome Symptoms (SPOTS); VOSS score; FSS score; PROMIS Cognitive Function Short Form 6a; EQ-5D score; PGI-S rating; PGI-C |
| NCT07163130 | Transcutaneous Auricular Vagus Nerve Stimulation in Postural Tachycardia Syndrome: a Prospective Cross-over Study | NOT_YET_RECRUITING | nan | Aristotle University Of Thessaloniki | Difference in Heart Rate change during the posture test, between the 2 treatment periods (on-treatment versus off-treatment). | Autonomic symptoms assessed using the Malmo POTS Score questionnaire |
| NCT07621068 | Hyperbaric Oxygen Therapy for Chronic Fatigue Syndrome (CFS) - A Prospective, Randomized, Double-Blind, Sham-Controlled Study | NOT_YET_RECRUITING | nan | Assaf-Harofeh Medical Center | Cardiopulmonary exercise test (CPET) | DePaul Post-Exertional Malaise Questionnaire (DPEMQ); Short Form-36 Health Survey (SF-36); Pittsburgh Sleep Quality Index (PSQI); Brief Symptom Inventory-18 (BSI-18); Montreal Cognitive Assessment (MoCA); NeuroTrax; Brain MRI; Brain EEG; Sleep EEG; Orthostatic |
| NCT07317401 | REenergizeME: Oxygen Therapy (OT) as a Novel Treatment for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) | NOT_YET_RECRUITING | nan | University of Aarhus | Change in SF-36 Vitality Domain score from baseline to post-treatment | Change in health-related quality of life (SF-36 domains); Change in fatigue severity (Fatigue Severity Scale, FSS); Change in functional capacity (FUNCAP-27); Change in autonomic symptoms (COMPASS-31); Objective autonomic, neurophysiological, and functional pe |
| NCT05454683 | Effect of Melatonin Plus Zinc Supplementation on Fatigue, Pain, Sleep Disturbances, Anxiety and Depression, and Autonomic Dysfunction in ME/CFS: a Randomized, Double-blind, Placebo | UNKNOWN | nan | Laboratorios Viñas, S.A. | Self-reported fatigue as assessed by the 40-item Fatigue Impact Scale (FIS-40) over the baseline in the study participants. | The health-related quality of life (HRQoL) as assessed by the Short-Form 36-Item Health Survey (SF-36) over the baseline in the study participants.; Sleep disturbances as assessed by the Pittsburgh Sleep Quality Index (PSQI) questionnaire over the baseline in |
| NCT04702217 | Physical Activity as a Complementary Treatment in Postural Orthostatic Tachycardia Syndrome - Evaluation of a Structured Physical Activity Program in Clinical Practice | WITHDRAWN | nan | Lund University | POTS questionnaire | Orthostatic hypotension questionnaire; SF-36; Orthostatic tests; Submaximal biking exercise |
| NCT05923840 | Mechanism of Chemoreflex and Baroreflex Alterations Causing Postural Tachycardia Syndrome in POTS Patients With Orthostatic Hyperpnea and Hypocapnia | UNKNOWN | nan | New York Medical College | Orthostatic tachycardia; Orthostatic Blood Pressure Changes; Orthostatic Changes in Systemic Vascular Resistance; Orthostatic Blood Volume Changes; Orthostatic Changes in Segmental Blood Flow; Orthostatic Changes in Cerebral Blood Flow; Orthostasis Induced Rat | Systemic changes in leg blood volumes during orthostatic testing.; Systemic changes in abdominal blood volumes during orthostatic testing. |
| NCT05289154 | Self- Applied Acupressure and Online Qigong for Patients Suffering From Chronic Fatigue After Corona Virus Infection 19 (COVID-19) - a Randomized Controlled Mixed-methods Study. | UNKNOWN | nan | Charite University, Berlin, Germany | SF-36 Physical Function subscale | EQ5D (EuroQoL 5 domains); SF36 PFS (Short Form 36 physical function subscale); Chalder Fatigue-Scale; VAS physical resilience (visual analogue scale); PHQ9 (Patient Health Questionnaire 9); VAS pain (visual analogue scale); hand grip strength; Spirometry; auto |
| NCT05851846 | Amygdala Insula Retraining in the Management of Long COVID Symptoms | UNKNOWN | nan | Miami VA Healthcare System | Modified Yorkshire COVID-19 scale | Heart rate variability; COMPASS-31 |
| NCT ID | Title | Status | Phase | Sponsor | Primary endpoint | Secondary endpoint |
|---|---|---|---|---|---|---|
| NCT05531019 | COVID-19 Sequelae: Treatment and Monitoring of Persistent Symptoms, a Decentralized Approach Focus on the Patient. Use of Dietary Supplement Based on Sea Urchin Eggs With Echinochr | COMPLETED | nan | Fernando Saldarini | Change of symptoms over time-points (baseline, 4 weeks, 8 weeks, 12 weeks) during rutine medical checkup.; Change of lung capacity over four times (baseline, 4 weeks, 8 weeks, 12 weeks) assessed during spirometry.; Change of walking distance during a six minut | Change of Von Willebrand Factor over time-points (baseline, 4 weeks, 12 weeks, 12 weeks) via blood sample.; Change of D Dimer over time-points (baseline, 4 weeks, 12 weeks, 12 weeks) via blood sample.; Change of HS-CRP over time-points (baseline, 4 weeks, 8 we |
| NCT05507190 | Self-management of Post COVID-19 Syndrome Using Wearable Biometric Technology | COMPLETED | nan | University of Manitoba | Change in lung capacity; Change in dyspnea; Change in fatigue; Chronic fatigue syndrome; Health-related quality of life; Postural orthostatic hypotension; Exercise capacity | Symptoms change; Patient satisfaction with the study |
| NCT05231512 | The Effects of a Music Therapy Respiratory Protocol on Post-Covid Respiratory Symptoms | COMPLETED | nan | Icahn School of Medicine at Mount Sinai | MRC dyspnea score | Self-reported Chronic Respiratory Questionnaire (CRQ-SR); Visual Analog Scale (VAS); Beck Depression Inventory - short form (BDI-SF); General Anxiety Disorder 7-item questionnaire (GAD-7); Hospital Anxiety and Depression Scale (HADS); Coronavirus Anxiety Scale |
| NCT05381675 | Short Term Outcomes of Tele-Rehabilitation in Patients With Post-Covid Syndrome | COMPLETED | nan | Harran University | Change from the baseline to the 6th week in mMRC (Modified Medical Research Council) Dyspnoea Scale | Change from the baseline to the 6th week in NPRS; Change from the baseline to the 6th week in the 5 times sit to stand test (5XSST); Change from the baseline to the 6th week in the Hospital Anxiety and Depression Scale; Change from the baseline to the 6th week |
| NCT07182578 | Programming Aquatic Therapy for POTS | COMPLETED | nan | California State University, Dominguez Hills | World Health Organization Quality of Life - Brief (WHOQOL-BREF); The DePaul Symptom Questionnaire (Short Form) (DSQ-SF); Composite Autonomic Symptom Score-31; Malmo POTS Scale (MAPS); ADLS, IADLS, and Vestibular Questionnaire; Active Stand Test; Single leg sta | The Stroop Test; Trail Making Test Parts A & B; Enrollment; Attrition Rate; Session attendance rate; Cost analysis; Health utilization changes; Satisfaction Analysis; Exercise self-efficacy; Goal Attainment Scaling; Beighton Score |
| NCT05630339 | Efficacy and Security of the Magnesium and Vitamin D Combination as Adjuvant Treatment of Post-COVID Syndrome. A Randomised Double-blind Clinical Trial | COMPLETED | nan | Coordinación de Investigación en Salud, Mexico | Change from Baseline Post-COVID syndrome symptoms at 4 months; Change from Baseline Post-COVID Functional Status at 4 months; Change from Baseline Serum vitamin D levels at 4 months; Change from Baseline Serum Magnesium levels at 4 months; Change from Baseline | Change from Baseline Fasting Blood Glucose levels at 4 months; Change from Baseline Serum Lipid Profile at 4 months; Change from Baseline Serum Calcium levels at 4 months; Change from Baseline Serum Creatinine levels at 4 months |
| NCT06379737 | Valutazione Degli Esiti a Medio-lungo Termine Della Sindrome Long Covid in Pazienti Trattati Con un Protocollo di Riabilitazione in Ambiente Termale o in Teleriabilitazione | COMPLETED | nan | Padua University General Hospital | Numerical Rating Scale (NRS); Hand grip strength; Barthel Dyspnea Scale; Fatigue Assessment Scale; Beck's Depression Inventory (BDI; Beck Anxiety Inventory (BAI); 12-Item Short Form Health Survey (SF-12) | Patients satisfaction |
| NCT06294756 | Effects of Sulfurous Thermal Waters Inhalations on Long-COVID Syndrome: a Double-blinded, Interventional, Randomized Case-control, Pilot Study on a Spa Centered Rehab Program | COMPLETED | nan | University of Roma La Sapienza | To determine whether Sulfurous Thermal water (STW) inhalations may have effects on post covid-pulmonary sequelae assessing changes in pulmonar functionality through spirometric parameters.; To determine whether Sulfurous Thermal water (STW) inhalations may hav | To assess if H2S present in STW can interfere with concentration of inflammatory markers ( as IL1B, IL-6, ACE, S100B, GSS, Hs-CRP) typically alterated in long covid patients.; To assess if H2S present in STW can interfere with concentration of inflammatory mar |
| NCT05476835 | Effect of Pulmonary Rehabilitation Program on Post Hospitalization Severe COVID- 19 Patients | COMPLETED | nan | Fayoum University Hospital | improvement in dyspnea scale; improvement in spirometry measures | improvement in oxygen saturation and 6 minute walk test |
| NCT05813873 | The Use of Incentive Spirometry (Triflow) in Patients With Long Covid | ACTIVE_NOT_RECRUITING | nan | European University Cyprus | Barthel Index; Barthel Index; Dyspnoea (Medical Research Council Dyspnoea Scale); Dyspnoea (Medical Research Council Dyspnoea Scale); Peak Flow Meter; Peak Flow Meter | Number of hospitalisation days; Muscle strength (Hand Grip); Muscle strength (Hand Grip); Muscle strength and endurance (30 seconds Sit to stand); Muscle strength and endurance (30 seconds Sit to stand); Balance (Berg Balance); Balance (Berg Balance); Cardiore |
| NCT05077241 | Efficacy of Home Inspiratory Muscle Training in Post-covid-19 Patients: a Randomized Clinical Trial | UNKNOWN | nan | Universidade Federal do Rio Grande do Norte | Respiratory muscle strength; Dyspnea - Medical Research Council; Quality of life (SF-36) | Pulmonary function; Exercise tolerance; Functional status; Anxiety and depression; Peripheral muscle strength; Adverse effects and adherence; Physical activity level; Cognition; Perception of effort and fatigue; Functional independence measure |
| NCT04678700 | Implementation of a Respiratory Physiotherapy Program in Post COVID-19 Patients Through Tele-assistance | UNKNOWN | nan | European University of Madrid | Euroqol-5d european quality of life-5 dimensions; Euroqol-5d european quality of life-5 dimensions; Dysnea scale Borg; Dysnea scale Borg; Respiratory rate; Respiratory rate; Effort dysnea Scale; Effort dysnea Scale; Anxiety; Anxiety; Level oxigen %; Level oxig | nan |
| NCT05725538 | Efficacy of Exercise-based mHealth Intervention for Patients With Post-acute COVID-19 Syndrome Based on Fatigue, Fitness, Post-exertional Dyspnea, Pain, Anxiety, Depression, Cognit | UNKNOWN | nan | University of Cadiz | Longitudinal Change from Baseline up to 24 Weeks Follow-up in Fatigue (Fatigue Severity Scale (FSS)); Longitudinal Change from Baseline up to 24 Weeks Follow-up in Post-exertional dyspnoea (Dyspnoea-12); Longitudinal Change from Baseline up to 24 Weeks Follow- | Longitudinal Change from Baseline up to 24 Weeks Follow-up in Pain intensity (Visual Analog Scale (VAS)); Longitudinal Change from Baseline up to 24 Weeks Follow-up in Upper limb strength (Arm curl test); Longitudinal Change from Baseline up to 24 Weeks Follow |
| NCT06374446 | Investigation of the Effect of Virtual Reality on Fatigue, Functional Capacity and Respiratory Function in Patients With Long Covid-19 | UNKNOWN | nan | Istinye University | Fatigue; Kinesiophobia; Evaluation of Respiratory Function; Shuttle Walking Test; Endurance Shuttle Walking Test; Sit and Reach Test; Peripheral Muscle Strength; The Nottingham Health Profile; Dyspnea; Energy Consumption; Posture Analysis; Covid-19 Yorkshire P | nan |
| NCT05271500 | Effect of Laser Acupuncture on Immunological Response and Dyspnea in Post Covid Syndrome Patients | UNKNOWN | nan | Cairo University | change in the level of CD 3 T cells; change in the level of cd4 T cells; change in level of interleukin 4; change in level of interleukin 6; change in lymphocyte count; change in level of dyspnea | change in fatigability |
| NCT ID | Title | Status | Phase | Sponsor | Primary endpoint | Secondary endpoint |
|---|---|---|---|---|---|---|
| NCT05121740 | Extension Study in a Cohort of Adult Patients With SARS-CoV-2 Infection Requiring Hospital Admission and Received Treatment With Plitidepsin in the APLICOV-PC Study | COMPLETED | PHASE1; PHASE2 | PharmaMar | Number and Percentage of Participants With Complications Related to Post COVID-19 Infection | Patients Requiring Oxygen Therapy; Patients With Complications Post COVID-19 Infection (Regardless Relationship, i.e. Related to COVID-19 Infection or Not).; Ratio of Partial Pressure Arterial Oxygen (PaO2) and Fraction of Inspired Oxygen (FiO2); Forced Expira |
| NCT05576662 | Selective Trial Of Paxlovid for PASC (STOP-PASC): Randomized Double-Blind Placebo-Controlled Pilot Trial of Paxlovid for the Treatment of PASC | COMPLETED | PHASE2 | Stanford University | Number of Participants With No, Mild, Moderate, or Severe Symptoms at Week 10 According to the Core Symptoms Severity Scale Score | Number of Participants With No, Mild, Moderate, or Severe Symptoms at Day 15 According to the Core Symptoms Severity Scale Score; Number of Participants Reporting Relief of at Least One Core Symptom for 2 Weeks; Number of Participants With Overall Alleviation |
| NCT03674541 | The Exercise Response to Pharmacologic Cholinergic Stimulation in Myalgic Encephalomyelitis / Chronic Fatigue Syndrome | COMPLETED | PHASE2 | Brigham and Women's Hospital | Change in Peak Oxygen Uptake (Peak VO2) Between the First and Second iCPET | Peak-Rest Oxygen Uptake (VO2); Peak Cardiac Output (Qc); Peak-Rest Cardiac Output (Qc); Peak Right Atrial Pressure (RAP); Peak-Rest Right Atrial Pressure (RAP); Peak Pulmonary Arterial Wedge Pressure (PAWP); Peak Stroke Volume (SV); Peak (Ca-vO2)/[Hgb]; Ventil |
| NCT05126563 | A Randomized, Double-blinded, Single-center, Phase 2 Efficacy, and Safety Study of Allogeneic HB-adMSCs for the Treatment of Patients With Chronic Post-COVID-19 Syndrome. | COMPLETED | PHASE2 | Hope Biosciences Research Foundation | Changes From Baseline in Visual Analog Scale of Neurological Symptoms. - Extreme Fatigue (ANCOVA Model); Changes From Baseline in Visual Analog Scale of Neurological Symptoms.. - Brain Fog (ANCOVA Model); Changes From Baseline in Visual Analog Scale of Neurolo | Changes From Baseline in Visual Analog Scale of Non-Neurological Symptoms. - Dyspnea at Rest (ANCOVA Model); Changes From Baseline in Visual Analog Scale of Non-Neurological Symptoms. - Dyspnea During Activity (ANCOVA Model); Changes From Baseline in Visual An |
| NCT05513560 | REcovering From COVID-19 Lingering Symptoms Adaptive Integrative Medicine (RECLAIM) | COMPLETED | PHASE2; PHASE3 | University Health Network, Toronto | SF-36 physical component score (PCS) | Symptoms scale; Symptom Checklist; Six Minute Walking Test (6MWT) with oximetry; TestMyBrain cognitive testing; Post COVID19 functional status scale; Reintegration to Normal Living Index (RNLI); Fatigue Scale; Brief Fatigue inventory; Post-Exertional Malaise; |
| NCT04988282 | Systemic Corticosteroids in Treatment of Post-COVID-19 Interstitial Lung Disease | COMPLETED | PHASE4 | Turkish Thoracic Society | % of patients with clinical improvement; % of patients with functional improvement; % of patients with radiological improvement | Improvement of diffusion capacity of lung for carbon monoxide (DLCO); Improvement of Forced Vital Capacity (FVC); Improvement of arterial oxygen saturation (SaO2); Improvement of Exercise Capacity; Improvement of mMRC dyspnea score; Respiratory-cause emergency |
| NCT05890534 | Pycnogenol® in People With Post-COVID-19 Condition: a Quadruple-blind, Randomized, Placebo-controlled Trial | COMPLETED | PHASE3 | University of Zurich | Health status (EQ-VAS) | Post COVID-19 symptoms; Fatigue; Dyspnea; Cognitive function; Anxiety and depression; Health-related quality of life (EQ-5D-5L); Functional exercise capacity; Physical activity; Soluble Thrombomodulin (sTM); von Willebrand Factor antigen (VWF:Ag); Syndecan-1; |
| NCT06383819 | Multicenter, Randomized, Double-blind, Placebo-controlled Parallel-group Study to Evaluate the Efficacy and Safety of Longidaza® for the Treatment of Patients With Residual Changes | COMPLETED | PHASE3 | NPO Petrovax | Change in Forced vital capacity (FVC) (visit 4) | Slowing the decline in respiratory function; Change in FVC (visit 5); The proportion of patients with an increase in the FVC (%); Dynamics of hemoglobin oxygen saturation (SpO2); The proportion of patients with SpO2 ≥ 93% and < 93%; The proportion of patien |
| NCT05619653 | Randomised Placebo Controlled Clinical Trial of Efficacy of MYOcardial Protection in Patients With Postacute inFLAMmatory Cardiac involvEment Due to COVID-19 | ACTIVE_NOT_RECRUITING | PHASE3 | Valentina Puentmann | Left ventricular ejection fraction | Scar burden by late gadolinium enhancement (LGE); Cardiopulmonary exercise testing (CPET); Mean T1 and T2 mapping; LV Volume (ml/m2) and LV mass (g/m2); LV strain %; Aortic stiffness (PWV); Aortic wall imaging (LGE); Average Symptom Score (Modified CCS, NYHA, |
| NCT05823896 | An Interventional, Double-Blinded, 2-Arm Study to Investigate the Efficacy of Orally Administered Nirmatrelvir/Ritonavir Compared with Placebo/Ritonavir in Non-hospitalized Adult P | COMPLETED | PHASE2 | Karolinska Institutet | Change from baseline in quality of life over time | Change from baseline in quality of life over time; Change from baseline in hemodynamic response over time; Change from baseline in dysautonomia over time; Change from baseline in fever in patients with POTS over time; Change from baseline in endothelial functi |
| NCT07492953 | Using Enhanced External Counterpulsation to Recover Cardiovascular Function for Patient of Chronic Diseases | COMPLETED | nan | National Defense Medical Center, Taiwan | Peak oxygen uptake (Peak VO₂) | The Six-Minute Walk Test (6MWT); Blood Pressure and Heart Rate; PROMIS Physical Health score; PROMIS Mental Health Score; PROMIS Sleep Disturbance Domain; Seattle Angina Questionnaire-7 (SAQ-7) summary score; COPD Assessment Test (CAT) score; Rose Dyspnea Scal |
| NCT05299333 | Comparison of the Effectiveness of Pulmonary Telerehabilitation and Physical Activity Recommendations in Patients With Pulmonary Fibrosis Due to COVID-19 | COMPLETED | nan | Istanbul University - Cerrahpasa | Submaximal exercise capacity; maximal exercise capacity; endurance exercise capacity; Peripheral muscle strength | Physical activity; Dyspnea; Fatigue; Physical fitness; Functionality; System usability; Emotional status; Body composition; Activities of daily living |
| NCT05119634 | The Effect of Whole Body Vibration Training in Individuals With Post COVID - 19 | COMPLETED | nan | Istanbul University - Cerrahpasa | 6 minutes walking test; 6 minutes pegboard and ring test; International Physical Activity Form (IPAQ); activity monitoring with Actigraf GT3X; peripheral muscle strength measurement; pulmonary function test | Post-COVID-19 Functional Status Scale; Chalder Fatigue Questionnaire; Clinical Frailty Scale; EuroQol- 5 Dimension; Hospital Anxiety and Depression Scale (HADS); Impact of Events Scale (IES-R); Pittsburgh Sleep Quality Index (PSQI); static posturography device |
| NCT05218174 | Exercise Training and Functional, Cognitive, and Emotional Well-being in Adults with Post-Acute Sequelae of SARS-CoV-2 (COVID-19) Infection (PASC): a Randomized Controlled Trial | COMPLETED | nan | Baylor Research Institute | Peak Oxygen Consumption (VO2max), mL/min; Peak Oxygen Consumption (VO2max), mL/min; Peak Oxygen Consumption (VO2max), mL/min; Score on Cognitive Function Self-Assessment Scale (CFSS); Score on Cognitive Function Self-Assessment Scale (CFSS); Score on Cognitive | Duration, mm:ss; Duration, mm:ss; Duration, mm:ss; Peak VO2 (absolute), mL/min; Peak VO2 (absolute), mL/min; Peak VO2 (absolute), mL/min; Peak VO2 (relative), mL/kg/min; Peak VO2 (relative), mL/kg/min; Peak VO2 (relative), mL/kg/min; Metabolic Equivalents; Met |
| NCT05703074 | The Efficacy and Safety of a Mental Intervention Program vs. Usual Care and Nicotinamide Riboside (NR) vs. Placebo for Improving Health-related Quality of Life in Long Covid: A 2 x | ACTIVE_NOT_RECRUITING | PHASE2 | University Hospital, Akershus | Health-related quality of life | Inflammation; Executive functioning; Fatigue; Dyspnoea; Global impression of change; Cost-effectiveness |
| NCT06330376 | Diaphragmatic Breathing Exercises for Post-COVID-19 Diaphragmatic Dysfunction (DD) | COMPLETED | nan | University of Minnesota | 6-minute walk test (6MWT) | PHQ9: Patient health questionnaire 9; GAD7: Generalized anxiety disorder 7-item; PROMIS score: Patient-Reported Outcomes Measurement Information System; QoL scale: Quality of life scale; FACIT fatigue scale 's Fatigue score; Modified Borg dyspnea scale; R |
| NCT05024474 | Effects of Inspiratory Muscle Training After Covid-19 | COMPLETED | nan | Karolinska Institutet | Change in Maximal Inspiratory Pressure (MIP) | Change in Maximal Expiratory Pressure (MEP); Change in Lung function; Change in walking distance during 6 minute walk test, expressed as percentage of predictive value,; Change in oxygen saturation during 6 minute walk test; Change in oxygen desaturation durin |
| NCT06492551 | Prospective Clinical Trial of Trak Tool Usage in Post-COVID-19 Patients. | COMPLETED | nan | Trak Health Solutions S.L. | Barthel index | Resting heart rate; Lung capacity; Oxygen saturation; Borg scale; Daniels scale; Trak satisfaction questionnaire |
| NCT05244044 | Changes in Functional Exercise Capacity After PUlmonary REhabilitation in Primary Care: a Randomized, Controlled, Multicenter, Pragmatic Trial in 134 Patients With Long COVID (PuRe | COMPLETED | nan | University Hospital, Antwerp | Exercise capacity | Change in physical activity; Change in COVID-19 related symptoms; Change in quality of life; Change in fatigue; Change in dyspnoea; Change in functional status; Change in work productivity and activity impairment.; Change in anxiety and depression symptoms.; C |
| NCT06814379 | Rehabilitation of Fatigue in Patients With Post-COVID-19 Syndrome | COMPLETED | nan | Universidad de Granada | Perceived Fatigue; Multidimensional Fatigue; Fatigue Severity; Fatigue Impact | COVID-19 information; Comorbidities; Dyspnea. The Borg Modified Scale; Dyspnea. Dyspnea-12; Dyspnea. Modified Medical Research Council (mMRC) Dyspnea Scale; Pain intensity; Psychological status; Sleep quality; Health-related Quality of life; Functional status: |
| NCT05139979 | Yogic Breathing and Guided Meditation for Long Covid Symptoms | COMPLETED | nan | Beth Israel Deaconess Medical Center | Compliance | Perceived Stress Scale (PSS); Profile of Mood States (POMS); Quality of Life Survey (SF12); Multidimensional Dyspnea Profile (MDP); Somatic Symptom Scale 8 Items (SS8); Qualitative Assessments |
| NCT06590324 | A Phase II, Multi-centre Open Label Study to Assess the Efficacy and Safety of Oral Apabetalone With Background Dapagliflozin in Subjects With Long -COVID-19 (Post-COVID-19 Conditi | RECRUITING | PHASE2; PHASE3 | Resverlogix Corp | patient acceptable symptom state (PASS) | Long COVID Symptom and Impact tools (LCST/LCIT); Patient-Reported Outcomes Measurement Information System (PROMIS)-Fatigue Short Form 7a (SF-7a); Baseline Dyspnea Index (BDI) & Transition Dyspnea Index (TDI); Post-COVID-19 Functional Status (PCFS) Scale; D |
| NCT07184372 | Radiofrequency 448khz in Patients Post Covid 19 With Respiratory Sequelae. | COMPLETED | nan | Clinica Gema Leon | Spirometry | Sadoul Dyspnea Scale; Leiscester Test; Chest measurements |
| NCT05532904 | Evaluation and Comparison of Multidisciplinary Day-hospital Versus Waiting List Management of Persistent Symptoms After an Acute Episode of COVID-19 | COMPLETED | nan | Assistance Publique - Hôpitaux de Paris | Quality of life | Quality of life; Fatigue; Dyspnea; Cognitive complaint; Pain; Patient's satisfaction; Physical fitness; Post-effort heart rate; Weight loss; BMI; Blood albumin; Nutritional risk; Health beliefs associated with persistent symptoms |
| NCT05003271 | Pulmonary Rehabilitation Post-COVID-19: a Pilot Study | COMPLETED | nan | University of Manitoba | Feasibility of the program; Recruitment rate; Intervention completion rate; Dropout rate; Patient safety; Patient satisfaction with the program | Change in lung capacity; Change in dyspnea; Changes in fatigue severity assessed with the Fatigue Severity Scale; Changes in fatigue assesses with the DePaul Symptom Questionnaire short-form; Change in sit-to-stand capacity; Change in post-exercise saturation; |
| NCT05715554 | Community-based Individualized Homeopathic Rehabilitation in Post COVID-19 Patients: Results of a Pilot, Pragmatic, Randomized, Open Label, Controlled Trial Investigating Acceptabi | COMPLETED | nan | Innowage Limited | Cough severity | Change in dyspnea; Change in Fatigue; change in Quality of Life |
| NCT06503913 | Cognitive Muscular Therapy for Patients With Long-COVID (Post COVID-19) and Breathing Pattern Disorder | COMPLETED | nan | University of Salford | Change in Nijmegen Questionnaire | Change in Modified COVID-19 Yorkshire Rehabilitation Scale (C19-YRSm) scale; Change in Dyspnea-12 questionnaire; Change in Self-evaluation of breathing questionnaire; Change in Composite Autonomic Symptom Score; Change in EQ-5D-5L; Change in WHO Disability Ass |
| NCT04657484 | Comparison of the Efficacy and Safety of Two Corticosteroid Regimens in the Treatment of Diffuse Lung Disease After Coronavirus Disease 2019 (COVID-19) Pneumonia | COMPLETED | nan | Post Graduate Institute of Medical Education and Research, Chandigarh | Proportion of subjects with a complete radiologic response | Proportion of subjects with a complete or good response radiologic response; Proportion of subjects with a good composite response; Forced vital capacity as a percentage of the predicted; Change in resting oxygen saturation; Proportion of subjects with oxygen |
| NCT05172206 | Symptom-based Rehabilitation Compared to Usual Care in Post-COVID - a Randomized Controlled Trial | COMPLETED | nan | Schön Klinik Berchtesgadener Land | Change from baseline Quality of life assessed by Short Form - 12 Questionnaire at week 4 and week 12 | Change from baseline COVID-related symptoms at week 4 and week 12; Change from baseline lung function at week 4 and week 12; Change from baseline blood gas analysis at week 4 and week 12; Change from baseline Cardiac Doppler echocardiography at week 4 and week |
| NCT05732571 | Post COVID REspiratory Mechanisms and the Efficacy of a Breathing Exercise Intervention for DYsregulated Breathing (REMEDY): COVID-19 | COMPLETED | nan | University of Nottingham | Breathlessness.; Function | Dyspnoea-12 Questionnaire; Nijmegen Questionnaire; Borg Scale of Breathlessness; Four metre Gait speed; Modified Minnesota Physical Activity; Capnography - in some volunteers; Chalder Fatigue Score; EQ5D Quality of Life score; Adherence; Breath hold, Respirato |
| NCT06631287 | Randomized Double-Blind Placebo-Controlled Trial EValuating Baricitinib on PERSistent NEurologic and Cardiopulmonary Symptoms of Long COVID (REVERSE-LC) | RECRUITING | PHASE3 | Wes Ely | CNS-Vital Signs Global Cognitive Index | Objective neuropsychological function domains of executive function, memory, processing speed, and motor speed including the CNS-Vital Signs subscale tests at 6-months.; Objective neuropsychological function domains of executive function, memory, processing sp |
| NCT04919031 | Inspiratory Muscle Trainer Impact on Post Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) COVID-19 Hypertensive Patients With Long Term Persistent Symptoms | COMPLETED | nan | Cairo University | maximal inspiratory pressure | sleeping quality scale; Timed stair climbing; 6 minute walk test; modified medical research council (mMRC) scale (0-4); Oxygen saturation; dyspnea borg scale; postural tachycardia syndrome; blood pressure (mmHg); lactate level; fatigue severity scale (0-63); P |
| NCT05204511 | Exercise and Post-COVID/Long-COVID: Effects of Different Training Modalities on Physical Performance, Heart Rate Variability, Inflammation, Health-Related Quality of Life, Cognitiv | COMPLETED | nan | University of Vienna | Change of peak oxygen consumption (VO2peak measured in ml/min/kg) | Change of maximum lower body isometric muscle strength (measured in N); Change of maximum hand grip strength (measured in kg); Change of Standard Deviation of RR-Intervals (SDNN measured in ms); Change of Root Mean Square of Successive Differences (RMSSD measu |
| NCT05298878 | Virtual Physical Rehabilitation for Patients Living with Long COVID | COMPLETED | nan | McGill University Health Centre/Research Institute of the McGill University Health Centre | Change in the basic mobility domain of the Activity Measure for Post-Acute Care (AM-PAC) | Change in lower-body strength; Change in functional mobility; Change in fatigue; Change in dyspnea; Change in health-related quality of life; Change in health state utilities; Change in anxiety and depression; Change in cognitive function; Change in the degree |
| NCT05630040 | Vagus Nerve Simulation for Long-COVID-19 | COMPLETED | nan | Icahn School of Medicine at Mount Sinai | Composite Dysautonomia Symptom Score (COMPASS 31); Composite Dysautonomia Symptom Score (COMPASS 31); Composite Dysautonomia Symptom Score (COMPASS 31); Composite Dysautonomia Symptom Score (COMPASS 31); Composite Dysautonomia Symptom Score (COMPASS 31) | Fatigue Severity Scale (FSS); Fatigue Severity Scale (FSS); Fatigue Severity Scale (FSS); Fatigue Severity Scale (FSS); Fatigue Severity Scale (FSS); Neuro Quality of Life Score; Neuro Quality of Life Score; Neuro Quality of Life Score; Neuro Quality of Life S |
| NCT06073002 | Effects of a Home-Based Exercise Intervention on Physical Function, Symptoms and Health-Related Quality of Life in Subjects with Long Covid | ACTIVE_NOT_RECRUITING | nan | University of Vienna | Change of peak oxygen consumption (VO2peak measured in ml/min/kg) | Change of maximum lower body isometric muscle strength (measured in N); Change of maximum hand grip strength (measured in kg); Change of Standard Deviation of RR-Intervals (SDNN measured in ms); Change of Root Mean Square of Successive Differences (RMSSD measu |
| NCT06974084 | A Multi-Center Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy of Maraviroc and Atorvastatin for the Treatment of Subjects With Long COVID/Post-Acute Se | NOT_YET_RECRUITING | PHASE2; PHASE3 | HealthBio, Inc. | Fatigue | Improvement in dysautonomia symptoms as reflected by the Composite Autonomic Symptom Score (COMPASS-31); Improvement in Dyspnea; Improved Cognitive Function, measured by the PROMIS (Patient-Reported Outcomes Measurement Information System) Cognitive Function v |
| NCT05019963 | Enhancing COVID Rehabilitation With Technology (ECORT): An Open-label, Single Site Randomized Controlled Trial Evaluating the Effectiveness of Electronic Case Management for Indivi | ACTIVE_NOT_RECRUITING | nan | University of Ottawa | Change in WHODAS 2.0 score | WHO Post-COVID CRF; PHQ-9; GAD-7; PSQI; PCL-5; EQ-5D-5L; Fatigue Severity Scale; Fatigue Numeric Rating Scale; Pain Numeric Rating Scale; MRC Dyspnoea Scale; WEMWBS; Oral Trail Making Test A and B; Hopkins Verbal Learning Test-Revised (HVLT-R); Digit Span subs |
| NCT05094622 | Physical Exercise in Patients With Postural Orthostatic Tachycardia Syndrome (POTS) After Covid-19. | ACTIVE_NOT_RECRUITING | nan | Karolinska Institutet | Change in Health-Related Quality of Life (HRQoL); Change in time in upright position and steps per day | Change in walking distance during 6 minute walk test; Change in oxygen saturation during 6 minute walk test; Change in oxygen desaturation during 6 minute walk test; Change in dyspnea during 6 minute walk test; Change in leg fatigue during 6 minute walk test; |
| NCT06231238 | A Randomised Controlled Trial Assessing the Efficacy of Balance Acceptance and Commitment Therapy (ACT) for Long COVID. | ACTIVE_NOT_RECRUITING | nan | King's College London | Physical Component Summary (PCS) of the 36-item Short Form Health Survey (SF-36) at Week 14 | EuroQol 5 Dimension - 5 Levels (EQ-5D-5L); Adult Service Use Schedule; Functional Assessment of Chronic Illness Therapy - Fatigue (FACIT-F); Modified Clinical Global Impressions Scale- Improvement (CGI-I); Pittsburgh Sleep Quality Index (PSQI); Modified Patien |
| NCT05167227 | The Long COVID and Fatiguing Illness Recovery Program - A Pragmatic, Quality Improvement, Professional Cluster, Randomized Controlled Trial. | ACTIVE_NOT_RECRUITING | nan | Family Health Centers of San Diego | Patient-Reported Outcomes Measurement Information System (PROMIS)-29 | Patient symptom checklist with associated severity for those present; If symptom is present, has patient experienced this in the past month; If symptom is present, how long has patient experienced this symptom; If symptom is present, did patient have this symp |
| NCT07021794 | Effectiveness of Treating Post-COVID-19 Conditions (Long COVID) With the SARS-CoV-2 Specific Monoclonal Antibody, Sipavibart | RECRUITING | PHASE2 | Nancy Klimas | Patient-Reported Outcomes Measurement Information System-29; Review of Treatment Related Adverse Events | Symptom-specific participant-reported outcome measures; Change in Simple Reaction Time (Milliseconds); Self-reported fatigue using MFI; Change in Heart Rate Post-6MWT; Processing Speed; Attention; Systolic Blood Pressure Response During NASA Lean Test; Diastol |
| NCT07374562 | Effect of Stellate Ganglion Block Treatment on Long COVID Symptoms: A Single-Blind, Single-Center Randomized Controlled Trial (STAR-CO) | RECRUITING | nan | Centre intégré universitaire de santé et de services sociaux de la Mauricie-et-du-Centre-du-Québec | Post-COVID-19 Functional Status Scale (PCFS); Fatigue Severity Scale (FSS); Brain Fog Scale (BFS) | Health-Related Quality of Life (SF-36); Dyspnea Severity (mMRC Scale); Lower-Limb Muscle Endurance (1-Minute Sit-to-Stand Test); Orthostatic Intolerance (NASA Lean Test) |
| NCT06168006 | Effects of a Physical Training Program Using a Mobile App on the Functionality and Cardiovascular Function of Individuals With Post-covid-19 Syndrome: Randomized Clinical Trial | RECRUITING | nan | University of Nove de Julho | Change from baseline in 6 min-walk test distance at 12 weeks; Change from baseline in Glittre test at 12 weeks; Change from baseline in sit and stand test at 12 weeks; Change from baseline in Post-Covid Functional Scale at 12 weeks | Change from baseline in Patient Functional Scale at 12 weeks; Change from baseline in Motor Evoked Potential at 12 weeks; Change from baseline in Modified Medical Research Dyspnea Scale at 12 weeks; Change from baseline in Chalder Physical Fatigue Scale at 12 |
| NCT06967428 | Effectiveness of Metabolic Modulation in Treating Post-vaccination Syndrome: A Prospective Study | NOT_YET_RECRUITING | PHASE2 | Independent Medical Alliance | PAC-19QoL Questionnaire; Six-minute walk test | Hemoglobin A1c; Sedentary blood lactate; Post-exertion blood lactate; C-Reactive Protein; Spike protein levels; Resting Heart Rate Variability; Heart rate variability during 6MWT; Resting Heart Rate; Heart Rate during 6MWT; Post-exercise Borg category-ratio 10 |
| NCT06156176 | Pursuing Reduction in Fatigue After COVID-19 Via Exercise and Rehabilitation (PREFACER): A Randomized Feasibility Trial | RECRUITING | nan | Lawson Research Institute of St. Joseph's | Recruitment; Intervention Fidelity; Retention; Zelen Design Acceptability | Change in 30-Second Sit-to-Stand Test; Change in Borg Scale of Perceived Physical Exertion; Change in The DePaul Symptom Questionnaire; Change in DePaul Symptom Questionnaire - Post-Exertional Malaise (short-form); Change in EQ-5D-5L; Change in Global Rating o |
| NCT06928506 | RECLAIM: Recovering From COVID-19 Lingering Symptoms Adaptive Integrative Medicine Trial - Effect of Hi-OxSR for the Treatment of Post COVID Condition (RECLAIM-HiOxSR) | RECRUITING | nan | University Health Network, Toronto | Simple reaction time (SRT) task from the TestMyBrain (TMB) Digital Neuropsychology Toolkit On-line survey tool; Verbal paired associates (VPA) task from the TestMyBrain (TMB) Digital Neuropsychology Toolkit On-line survey tool | All cognitive performance tasks (measured by the TESTMYBRAIN.org (TMB) neuropsychology toolkit; Brain Fog Questionnaire; Brief Fatigue Inventory; Short Form (SF)-36; Safety, adverse events and serious adverse events; Symptom Checklist; The DePaul Symptom Post- |
| NCT04801940 | HElping Alleviate the Longer-term Consequences of COVID-19 (HEAL-COVID): a National Platform Trial | UNKNOWN | PHASE3 | Cambridge University Hospitals NHS Foundation Trust | Hospital free survival. | All-cause mortality; Hospital readmission after discharge from index hospital admission; Suspected Serious Adverse Reactions; FACIT-Fatigue; Modified MRC Dyspnoea Scale; COVID-19 core outcome measure for recovery; Patient Health Questionnaire-2 (PHQ-2); Genera |
| NCT06829940 | Efficacy of Baduanjin Exercise in COVID-19 Contraction Patients With Idiopathic Chronic Fatigue | RECRUITING | nan | Cairo University | Pulmonary function: By Spirometry Device: | Pulmonary function: By Spirometry Device:; Measuring functional capacity: By Six-minute walk test (6MWT); Modified Borg dyspnea scale (MBDS); Strength of lower limb muscles By a thirty-second sit-to-stand test; Endurance of upper limb muscles: by the maximal r |
| NCT06452095 | RECLAIM: Recovering From COVID-19 Lingering Symptoms Adaptive Integrative Medicine Trial - Effect of Hyperbaric Oxygen Therapy for the Treatment of Post COVID Condition (RECLAIM-HB | RECRUITING | nan | University Health Network, Toronto | Simple reaction time [SRT] task from the TestMyBrain (TMB) Digital Neuropsychology Toolkit; Verbal paired associates [VPA] task from the TestMyBrain (TMB) Digital Neuropsychology Toolkit | Symptoms scale; Symptom Checklist; Six Minute Walking Test (6MWT) with oximetry; SF-36; TestMyBrain cognitive testing; Post COVID19 functional status scale; Reintegration to Normal Living Index (RNLI); The Fatigue Scale; Brief Fatigue inventory; Post-Exertiona |
| NCT06045338 | Mind Body Intervention for Long COVID | RECRUITING | nan | Beth Israel Deaconess Medical Center | Somatic Symptom Score-8 (SSS-8) | Short Form Brief Pain Inventory (BPI); Fatigue Severity Scale (FSS); The Multidimensional Dyspnea Profile (MDP); Generalized Anxiety Disorder form 7 (GAD-7); Patient Reported Outcomes Measurement Information System survey for function disability (PROMIS); End |
| NCT05877534 | Effects of Individual Tailored Physical Exercise in Patients With Post COVID-19 Condition, Diagnosed With Postural Orthostatic Tachycardia Syndrome (POTS) - a Randomized Controlled | ENROLLING_BY_INVITATION | nan | Karolinska Institutet | Change in time in upright position and steps per day; Change in Health-Related Quality of Life (HRQoL) | Change in walking distance during 6 minute walk test; Change in oxygen saturation during 6 minute walk test; Change in dyspnea during 6 minute walk test; Change in leg fatigue during 6 minute walk test; Change in exertion during 6 minute walk test; Change in h |
| NCT04856111 | A Study of the Efficacy and Safety of Pirfenidone vs. Nintedanib in the Treatment of Fibrotic Lung Disease After Coronavirus Disease-19 Pneumonia | UNKNOWN | PHASE4 | Post Graduate Institute of Medical Education and Research, Chandigarh | Change in the forced vital capacity (FVC) | Proportion of subjects with improvement or stabilization; Proportion of subjects with a good composite response; Change in dyspnea score on modified Medical Research Council scale; Severity of dyspnea on the Functional Assessment of Chronic Illness Therapy - D |
| NCT04652518 | A Phase 2 Randomized, Double-blind, Placebo-controlled Trial and Open Label Extension to Evaluate the Safety and Efficacy of Deupirfenidone (LYT-100) in Post-acute COVID-19 Respira | TERMINATED | PHASE2 | PureTech | Change in distance walked on the six-minute walk test (6MWT) | Change in Dyspnoea-12 score; Change in Saint George Respiratory Questionnaire-I (SGRQ-I) score; Change in Modified Borg Dyspnoea Scale (mBDS) score; Quality of Life assessment as collected using the SF-36 |
| NCT05851859 | Randomized Controlled Trial Evaluating the Effectiveness of a Breathing Control Technique on Long COVID Symptoms at the Reunion University Hospital | RECRUITING | nan | Centre Hospitalier Universitaire de la Réunion | Evaluation of the effectiveness of a respiratory training to cardiac coherence on the reduction in the symptomatology of patients with Long COVID. | Evaluation of the effectiveness of a respiratory training to cardiac coherence on the decrease of overall symptoms over time; Evaluation of the effectiveness of a respiratory training to cardiac coherence on the decrease of specifics symptoms : fatigue; Evalua |
| NCT07621588 | Effects of Diaphragmatic Breathing Exercises Combined With Diaphragmatic Electrostimulation Using KOTS Currents in Patients With Long COVID: A Pilot Randomized Controlled Trial | NOT_YET_RECRUITING | nan | Universidad Pontificia de Salamanca | Forced Vital Capacity | Forced Expiratory Volume in One Second; Peak Expiratory Flow; FEV1/FVC Ratio; Basal Oxygen Saturation; Physical Function; Dyspnea; Quality of Life with SF-36 questionnaire; Fatigue |
| NCT05116761 | Bone Marrow Mesenchymal Stem Cell Derived Extracellular Vesicles Infusion Treatment for Post-Acute and Chronic Post-COVID-19 Syndrome: A Phase I/II Clinical Trial | WITHDRAWN | PHASE1; PHASE2 | Direct Biologics, LLC | Increased distance on Six Minute Walk Test (6MWT); Incidence of Serious Adverse Events (SAEs) | EuroQol-5D (EQ-5D); Medical Research Council (MRC) Dyspnea Scale |
| NCT06165978 | Physical Activity Coaching in Patients with Post-COVID-19. a Randomised Clinical Trial. | SUSPENDED | nan | University of Alcala | Change in Physical activity (PA) patterns (steps/day) from baseline (pre-intervention), at 12 weeks (post-intervention), 6 months and 12 months; Change in Physical activity (PA) patterns (time spent in light PA per day) from baseline (pre-intervention), at 12 | Change in isometric quadriceps strength from baseline (pre-intervention) at 12 weeks (post-intervention), 6 months and 12 months; Change in handgrip force from baseline (pre-intervention) at 12 weeks (post-intervention), 6 months and 12 months; Change in maxim |
| NCT07397910 | Clinical Trial to Analyze the Effectiveness of a Natural Compound on Chronic Immune-mediated Inflammatory Status in Subjects Who Have Had SARS-CoV-2 Infection. | NOT_YET_RECRUITING | nan | Universidad Católica San Antonio de Murcia | Immunoinflammatory profile | Clinical signs; Short Form 12 Health Survey; Sleep quality; Sleep efficiency; Fatigue; Dyspnea; Depression; Anxiety; Hospital Anxiety and Depression; Stress level; Cardiorespiratory fitness.; The Rate of Force Development; Maximum Voluntary Isometric Contracti |
| NCT06544395 | Efficacy of Non-invasive Neuromodulation Treatments for Post-COVID-19 Sequelae in Patients With Musculoskeletal, Respiratory and Neurological Conditions Due to Impaired Taste and S | NOT_YET_RECRUITING | nan | Clinica Gema Leon | ad hoc patient survey; sex, age, vaccination and number of months with symptoms; Number of participants with musculoskeletal, respiratory and neurological sequelae of taste and smell after COVID-19 | SDOQ-NS questionnaire for social impairments due to loss of smell; SF12 Quality of Life Questionnaire; Brief Smell Identification Test: Assessment of smell.; EuroQoL 5-D scale (validated translation into Spanish) for quality of life.; upper limb functional ind |
| NCT04905888 | Hyperbaric Oxygen Therapy for Long COVID Patients With Pulmonary Sequela - Pilot Study | WITHDRAWN | PHASE2 | Peter Lindholm | Exercise tolerance | Excercise tolerance walk test; Dyspnea perception 1; Dyspnea perception 2; Pulmonary function test 1; Pulmonary function test 2; V̇A/Q̇ matching measured with magnetic resonance imaging |
| NCT05398692 | Long COVID-19 Rehabilitation & Research Program | TERMINATED | nan | Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center | Change in aerobic capacity (Peak Oxygen Uptake) at 10 weeks after rehabilitation comprehensive (normal intensity) pulmonary rehabilitation program. | Short Form (SF-36); Fatigue Severity Scale (FSS); General Anxiety Disorder Screener (GAD-7); Pittsburg Sleep Quality Score (PSQI); Modified Medical Research Council Dyspnea Scale (mMRC); Modified DePaul Assessment for Post-Exertional Malaise (DSQ-PEM); Patient |
| NCT06231225 | Study on the Effect of Incentive Spirometer-based Respiratory Training on the Long COVID-19 Symptoms in Chronic Disease Patients After Recovery From COVID-19 | NOT_YET_RECRUITING | nan | National Taipei University of Nursing and Health Sciences | Post-COVID-19 Functional Status scale | Lung function indices; Hemoglobin and oxygen levels; Six-minute walk test (6MWT); Dyspnoea-12 (D-12) scale |
| NCT04924881 | Chinese Medicine for Residue Symptoms of COVID-19 Recovered Patients- A Double-blind, Randomized, Placebo-controlled Study | UNKNOWN | PHASE2 | Chinese University of Hong Kong | The Change of Fatigue Severity Score | Long Term Symptom Assessment; The Change of Fatigue Severity Score (FSS); Improvement of dyspnoea using modified British Medical Research Council (mMRC) dyspnoea scale; The change of EuroQol five-dimension five-level (EQ-5D-5L)5L) questionnaire and it's V |
| NCT05855356 | The Long-CoviD Patients Causal Diagnosis and Rehabilitation Randomized Feasibility Controlled Trial in Patients With Dysautonomia: the LoCoDiRe-Dys Study | UNKNOWN | nan | Evangelismos Hospital | Number of patients with lack of definite Dysautonomia Diagnosis; Compliance, Adverse Events and Protocol Titration to examine feasibility of the trial | 10 minutes NASA Lean Test; Six minute Walk Test; 1 minute sit to stand test; Fatigue Severity Scale; modified Medical Research Council Dyspnea Scale; Nijmegen Questionnaire; Montreal Cognitive Assessment; International Physical Activity Questionnaire; Hospital |
| NCT05445531 | Low-field Magnetic Resonance Imaging to Assess Changes in Pulmonary Function Parameters in Confirmed Pediatric SARS-CoV-2 Infection | UNKNOWN | nan | University of Erlangen-Nürnberg Medical School | Functional lung assessment (LF-MRI) | Morphologic lung assessment (LF-MRI); Cardiological functional diagnostics (VO2); Cardiological functional diagnostics (VO2max); Cardiological functional diagnostics (VT2); Cardiological functional diagnostics (VCO2); Cardiological functional diagnostics (HR); |
| NCT06159296 | Randomised, Placebo-controlled, Double-blind Cross-over Study to Investigate the Therapeutic Effects of an Inhaled Hydrogen/Oxygen Mixture to Improve Long COVID Symptoms | UNKNOWN | nan | Oxford Brookes University | Breathlessness | Exertional dyspnea; Physical capacity (muscle fatigue); Psychological state and cognitive ability; General long COVID symptom burden |
| NCT05725538 | Efficacy of Exercise-based mHealth Intervention for Patients With Post-acute COVID-19 Syndrome Based on Fatigue, Fitness, Post-exertional Dyspnea, Pain, Anxiety, Depression, Cognit | UNKNOWN | nan | University of Cadiz | Longitudinal Change from Baseline up to 24 Weeks Follow-up in Fatigue (Fatigue Severity Scale (FSS)); Longitudinal Change from Baseline up to 24 Weeks Follow-up in Post-exertional dyspnoea (Dyspnoea-12); Longitudinal Change from Baseline up to 24 Weeks Follow- | Longitudinal Change from Baseline up to 24 Weeks Follow-up in Pain intensity (Visual Analog Scale (VAS)); Longitudinal Change from Baseline up to 24 Weeks Follow-up in Upper limb strength (Arm curl test); Longitudinal Change from Baseline up to 24 Weeks Follow |
| NCT05947617 | Phase 1 Study: Assessing VIX001 Safety, Efficacy, and Dosing in Post Acute COVID-19 Syndrome (PACS) Patients With Neurological Symptoms and Cognitive Impairment. | UNKNOWN | PHASE1 | Neobiosis, LLC | Change from Baseline Six Minute Walk Test (6MWT) with oximetry.; Change from Baseline Transthoracic Echocardiogram in 3 Dimensions (3-D TTE).; Change from Baseline Pulmonary Function Test (PFT) with bronchodilation if abnormal.; Change from Baseline Sleep time | PROMIS; mMRC Scale.; General Anxiety Disorder (GAD-7).; Personal Health Questionnaire Depression Scale (PHQ-8). |
| NCT05918965 | Effects of Transcutaneous Electrical Neurostimulation on Female Patients With Long COVID - a Pilot Study | UNKNOWN | nan | Medical University of Vienna | Heart rate variability | blood pressure and pulse; Saliva cortisol; Questionnaire Brief Fatigue Inventory (BFI); Questionnaire Short form (SF)-36; Questionnaire Borg-Scale; Questionnaire Insomnia Severity Index (ISI); Post-COVID-19 Functional Status scale (PCFS) |
| NCT06091358 | Does a 4-week Inspiratory Muscle Training Intervention (IMT) Increase Inspiratory Muscle Pressure (MIP) and Other Functional Outcomes in People With Long COVID? A Pilot Investigati | UNKNOWN | nan | University of Bath | Change in Maximal inspiratory muscle pressure (MIP) at week 4. | Change in Peak expiratory flow (PEF) at week 4.; Change in Ventilatory threshold (VT) at week 4.; Difference between Baseline Dyspnea Index score (BDI) and Transitional Dyspnea index (TDI).; Change in 6 minute walk test distance at week 4; Change in Forced ven |
| NCT05975034 | Investigation of the Use of a Probiotic Supplement in People With Long COVID | UNKNOWN | nan | Sheffield Hallam University | Fatigue severity scale (FSS); FACIT fatigue scale; EQ-5D-5L; Ability to Participate in Social Roles and Activities - PROMIS Short Form 8a; Ecological Momentary Assessment (EMA) app | IBS-SSS; Gastrointestinal Symptom Rating Scale; MRC Dyspnoea scale; International. Physical Activity Questionnaire (short form); Accelerometery data; Cambridge Neuropsychological Test Automated Battery (CANTAB); 16S rRNA sequencing; Analysis of inflammatory ma |
| NCT04836351 | Feasibility, Usefulness and Evaluation of a Concentrated Rehabilitation for Patients With Persistent Symptoms Post COVID-19 | UNKNOWN | nan | Western Norway University of Applied Sciences | Cardiopulmonary exercise test (CPET); Chalder Fatigue Questionnaire (CFQ) | International Physical Activity Questionnaire (IPAQ); Generalized Anxiety Disorder (GAD-7); Patient Health Questionnaire (PHQ-9); Bergen Insomnia Scale (BIS); Client Satisfaction Questionnaire (CSQ-8); Work and Social Adjustment Scale (WSAS); The Brief Illness |
| NCT05629884 | Efficacy of a Physical and Respiratory Rehabilitation Program (COPERIA-REHAB) for Patients With Persistent COVID-19 (SARS-CoV-2). | UNKNOWN | nan | Fundacin Biomedica Galicia Sur | Six Minutes Walking test | mMRC dyspnea scale; SF-36 Health Questionnaire; Maximal Handgrip Strenght; 1 Minute Sit to Stand test; P maximal inspiratory and P maximal expiratory; Insomnia Severity Index. |
| NCT05543408 | Long COVID-19 Syndrome in Primary Care: A Novel Protocol of Exercise Intervention "CON-VIDA Clinical Trial" | UNKNOWN | nan | Universidad San Jorge | Change in Lower Limb Strength: 30 s Sit-to-Stand test; Change in Lower Limb Strength: 5 times Sit-to-Stand Test; Change in Handgrip Strength; Chance in upper limbs strength: Arm Curl Biceps; Change in Balance: Flamingo Balance Test; Change in walking speed: Br | Body Composition; Change in Quality of Life-SF-36; Change in The International Physical Activity Questionnaire (IPAQ); Change in Modified Medical Research Council dyspnea scale (mMRC); Change in Modified Fatigue Impact Scale (MFIS); Change in Hospital Anxiety |
| NCT05722730 | Effects of Pilates in Patients With Post- -COVID-19 Syndrome: Controlled and Randomized Clinical Trial | UNKNOWN | nan | Michele de Aguiar Zacaria | Functional Capacity; Functional Status | Peripheral muscle endurance; Respiratory muscle strength; Peripheral muscle strength; Dyspnea; Health-related quality of life |
| NCT06063031 | Investigation of a Specialized Nutritional Intervention and Rehabilitation Treatment in Patients With Post-COVID Condition to Improve Their Quality of Life: ARACOV-02 | UNKNOWN | nan | Instituto de Investigación Sanitaria Aragón | Changes in the Quality of life (EQ-5D) | Changes in the Biomarkers; Changes in the Fatigue Severity Scale (FSS); Changes in the Modified Medical Research Council Scale (mMRC); Changes in the Measurements of peak inspiratory pressure and peak expiratory pressure; Changes in the Functional capacity as |
| NCT05543590 | Effect of Plasmapheresis on Clinical Improvement and Biological Parameters of Patients With Long-haul COVID: PLEXCOVIL Study, a Randomized Controlled Study. | WITHDRAWN | nan | Hôpital Européen Marseille | Percentage of patients whose fatigue has decreased by 30% on the Chalder scale at M3 compared to its initial state measured at baseline | Observation of the evolution of the fatigue (Chalder scale) felt by the patients during the 6 months of the study in the two groups of patients; Evaluation of the quality of life (SF-36) of patients at month 3 and month 6; Evaluation of the overall impression |
| NCT ID | Title | Status | Phase | Sponsor | Primary endpoint | Secondary endpoint |
|---|---|---|---|---|---|---|
| NCT05592418 | A Randomized, Double Blind, Placebo Controlled Study to Evaluate the Efficacy and Safety of Ampligen® in Patients With Post-COVID Conditions | COMPLETED | PHASE2 | AIM ImmunoTech Inc. | Change From Baseline to Week 13 in PROMIS Fatigue Score (T-Score) | Change From Baseline to Week 6 in PROMIS Fatigue Score (T-Score); Change From Baseline to Week 13 in PROMIS Fatigue Score (T-Score), Excluding Response to Item Seven; Change From Baseline to Week 6 and Week 13 in Distance Traveled During 6-minute Walk Test (6M |
| NCT05965726 | RECOVER-VITAL: A Platform Protocol for Evaluation of Interventions for Viral Persistence, Viral Reactivation, and Immune Dysregulation in Post-Acute Sequelae of SARS-CoV-2 Infectio | COMPLETED | PHASE2 | Kanecia Obie Zimmerman | Percentage of Participants Who Improved in Cognitive Dysfunction Symptom Cluster, as Measured by Patient-Reported Outcomes Measurement Information System (PROMIS) Cognitive 8a Function T-score; Percentage of Participants Who Improved in Autonomic Dysfunction S | Percentage of Participants Who Improved in Cognitive Dysfunction Symptom Cluster, as Measured by a Neurocognitive Battery; Percentage of Participants Who Improved in Autonomic Dysfunction Symptom Cluster, as Measured by the Active Stand Test; Percentage of Par |
| NCT05877508 | An Exploratory, Randomized, Double-Blind Placebo-Controlled Study to Assess the Safety of an Anti-SARS-CoV-2 Monoclonal Antibody and Response to Treatment in Individuals With Long | ACTIVE_NOT_RECRUITING | PHASE2 | Michael Peluso, MD | Patient-Reported Outcomes Measurement Information System (PROMIS)-29 Physical Health Summary Score | Patient-Reported Outcomes Measurement Information System (PROMIS)-29 Physical Health Summary Score; Patient-Reported Outcomes Measurement Information System (PROMIS)-29 Mental Health Summary Score; Patient-Reported Outcomes Measurement Information System (PROM |
| NCT06161688 | Placebo-Controlled, Randomized Trial of Ensitrelvir (S-217622) for Viral Persistence and Inflammation in People Experiencing Long COVID (PREVAIL-LC) | ACTIVE_NOT_RECRUITING | PHASE2 | Timothy Henrich | Patient-Reported Outcomes Measurement Information System (PROMIS)-29 Physical Health Summary Score | Patient-Reported Outcomes Measurement Information System (PROMIS)-29 Physical Health Summary Score; Patient-Reported Outcomes Measurement Information System (PROMIS)-29 Mental Health Summary Score; Patient-Reported Outcomes Measurement Information System (PROM |
| NCT05638633 | Prednisolone and Vitamin B1, B6, and B12 in Patients With Post-COVID-19-Syndrome (PC19S) - a Randomized Controlled Trial in Primary Care | COMPLETED | PHASE3 | Wuerzburg University Hospital | Pilot phase: Proportion of participants retained after 28 days; Confirmatory phase: Mean difference in PROMIS Total Score from day 0 to day 28 | PROMIS total and subscores; Measure Yourself Medical Outcome Profile (MYMOP); Overall assessment of functional status; PC19 symptom list; EQ-5D-5L; visual analogue scale; PHQ 8; Chalder Scale; Numeric rating scale for pain; Testbatterie zur Aufmerksamkeitsprüf |
| NCT06404112 | RECOVER-SLEEP: A Platform Protocol for Evaluation of Interventions for Sleep Disturbances in Post-Acute Sequelae of SARS-CoV-2 Infection (PASC) | COMPLETED | PHASE2 | Duke University | Change in total score of the PROMIS 8b SD to assess sleep disturbance; Change in sleep onset variability, assessed using a wearable device | Change in total score of the PROMIS 8a SRI to assess sleep-related impairment; Change in PROMIS 10a Fatigue score; Change in an objective neurocognitive battery score; Change in ECog2 measure; Change in PASC Symptom Questionnaire responses; Change in total sco |
| NCT06316843 | A Randomized, Double-Blinded, Placebo-Controlled, Pilot Study of the Combination of Valacyclovir + Celecoxib (IMC-2) for the Treatment of Post-Acute Sequelae of SARS-CoV-2 Infectio | COMPLETED | PHASE2 | Bateman Horne Center | Fatigue assessed with the Patient-Reported Outcomes Measurement Information System (PROMIS) Fatigue 7a Instrument | nan |
| NCT05668091 | An Interventional Decentralized Phase 2, Randomized, Double-Blind, 2-Arm Study to Investigate the Efficacy and Safety of Orally Administered Nirmatrelvir/Ritonavir Compared with Pl | COMPLETED | PHASE2 | Harlan M Krumholz | National Institutes of Health (NIH) Patient-Reported Outcomes Measurement Information System (PROMIS)-29 version 2.1 Physical Health Summary Score | Modified General Symptom Questionnaire-30 (Modified GSQ-30); PROMIS® Cognitive Function v.2.0 - Short Form 6a; COVID Core Outcome Measure for Recovery; EuroQol EQ-5D-5L Utility Score-VAS (USA Version); Functional Assessment of Chronic Illness Therapy (FACIT)-I |
| NCT06404099 | RECOVER-SLEEP: A Platform Protocol for Evaluation of Interventions for Sleep Disturbances in Post-Acute Sequelae of SARS-CoV-2 Infection (PASC) | COMPLETED | PHASE2 | Duke University | Change in total score of the PROMIS 8a SRI to assess sleep-related impairment | Change in total score of the PROMIS 8b SD to assess sleep disturbance; Change in PROMIS 10a Fatigue score; Change in an objective neurocognitive battery score; Change in ECog2 measure; Change in PASC Symptom Questionnaire responses; Change in total score on th |
| NCT04944121 | A Phase 2, Double-blind, Placebo-controlled Study of RSLV-132 in Subjects With Post-acute COVID-19 (Long COVID) | COMPLETED | PHASE2 | Resolve Therapeutics | PROMIS Fatigue SF 7a T-score | FACIT Fatigue questionnaire; Long COVID-19-related Symptom Assessment patient questionnaire; Patient-reported Global Impression of Severity questionnaire; Digit Symbol Substitution Test; Physician Global Assessment |
| NCT05638620 | Evaluating the Effectiveness of Dual Sympathetic Blocks for Patients Experiencing Sympathetically-Mediated Symptoms From Post-Acute Sequelae of SARS-CoV-2 (PASC) | COMPLETED | PHASE1 | Jonathann Kuo, MD | Patient-Reported Outcomes: PROMIS-29 Score; Depression; Anxiety; Physical function; Pain interference; Fatigue; Sleep disturbance; Ability to participate in social roles and activities status | Autonomic Symptoms: COMPASS-31 Score |
| NCT04828668 | A Single-Blind, Randomized, Placebo Controlled, Study to Evaluate the Benefits and Safety of Endourage Targeted Wellness Formula C™ Sublingual Drops in People With Post -Acute COVI | COMPLETED | nan | Endourage, LLC | Reduction in patient reported outcomes measures on the Patient Reported Outcomes Measurement Information System (PROMIS ®) assessment tools.; PATIENT GLOBAL IMPRESSION OF CHANGE (PGIC) | Study product related adverse events and side effects. |
| NCT06391489 | Piloting A Telehealth Deliverable Self-Management and Cognitive Training Program (HOBSCOTCH, HOme Based Self-Management and COgnitive Training CHanges Lives) for People With Post A | ACTIVE_NOT_RECRUITING | nan | Dartmouth-Hitchcock Medical Center | Change in overall quality of life as measured by comparing PROMIS-10 Global Health scores pre- and post-HOBSCOTCH-PACS intervention.; Change in subjective cognition as measured by comparing Neuro-QOL Item Bank v2.0 Cognitive Function scores pre- and post-HOBSC | Change in objective cognition as measured by comparing Symbol-Digit Modalities Test scores pre- and post-HOBSCOTCH-PACS intervention.; Change in objective cognition as measured by comparing California Verbal Learning Test-III scores pre- and post-HOBSCOTCH-PAC |
| NCT06821087 | Evaluating the Neuromodulatory Effect of Ketamine in Long COVID: A Pilot Study Targeting Fatigue and Neurocognitive Symptoms | ENROLLING_BY_INVITATION | PHASE2 | University of Texas at Austin | PROMIS SF v1.0 - Fatigue 8a; PROMIS SF v2.0 Cognitive Function 4a; BrainCheck Cognitive Battery; Number of participants with treatment-related adverse events as assessed by standardized interview | PROMIS Global 10 v1.2; NASA Task Load Index (NASA-TLX); Patient Health Questionnaire-9 (PHQ-9); Generalized Anxiety Disorder-7 (GAD-7); Depression in Medically Ill 10 Scale (DMI-10); Long COVID Review of Systems; Neuroimaging (MRI) Outcomes; Serum Biomarker An |
| NCT06766825 | Phase II Proof-of-concept, Randomized, Double-blind, Placebo-controlled Study to Evaluate the Efficacy and Safety of Plitidepsin in Adults With Post-COVID-19 Condition (PCC) | RECRUITING | PHASE2 | Fundación FLS de Lucha Contra el Sida, las Enfermedades Infecciosas y la Promoción de la Salud y la Ciencia | Change in the overall health in patients from each group using patient reported outcomes measurement information system score (PROMIS-29®). | To compare the safety/tolerability of Plitidepsin Vs placebo in terms of adverse events in patients with PCC.; To compare the incidence of Treatment-Emergent Adverse Events (TEAEs) between groups.; To compare changes in the overall health in patients from each |
| NCT05167227 | The Long COVID and Fatiguing Illness Recovery Program - A Pragmatic, Quality Improvement, Professional Cluster, Randomized Controlled Trial. | ACTIVE_NOT_RECRUITING | nan | Family Health Centers of San Diego | Patient-Reported Outcomes Measurement Information System (PROMIS)-29 | Patient symptom checklist with associated severity for those present; If symptom is present, has patient experienced this in the past month; If symptom is present, how long has patient experienced this symptom; If symptom is present, did patient have this symp |
| NCT07140094 | Long-Covid-19 Alleviation Through Learning Mindfulness Study (LONG-CALM) | RECRUITING | nan | Columbia University | Mean Score of Patient-Reported Outcomes Measurement Information System (PROMIS) Global 10 Score | Change in PROMIS Global 10 Score; Post-Acute Sequelae of SARS-CoV-2 (PASC) Score; Patient Health Questionnaire 9 (PHQ9) Score; Generalized Anxiety Disorder 7 (GAD7) Score; Impact of Event 6 (IES-6) Scores; State Mindfulness Scale for Physical Activity Score; D |
| NCT07285473 | Low-dose Naltrexone (LDN) for the Treatment of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS): Dose-Finding | NOT_YET_RECRUITING | PHASE2 | University of Alabama at Birmingham | PROMIS Fatigue Short Form 7a | nan |
| NCT06863207 | Autonomic Reactivity to Restore a Dysregulated Brain-Gut Axis Via Targeted Therapy | RECRUITING | nan | Medical College of Wisconsin | Patient-Reported Outcomes Measurement Information System (PROMIS) Pediatric Profile-37 | 2. Patient Assessment of upper GastroIntestinal Symptom Severity Index |
| NCT05931497 | A Pilot Study of Whole Body Hyperthermia for Long Covid or Post-Acute Sequelae of COVID-19 (PASC) | RECRUITING | nan | Massachusetts General Hospital | The Patient Reported Outcome Measurement Information System Fatigue-Short Form v1.0 -Fatigue 7a (PROMIS F-SF) | Patient-Reported Outcomes Measurement Information System (PROMIS-29); Patient Health Questionnaire-9 (PHQ); The Perceived Stress Scale (PSS); Patient-Reported Outcomes Measurement Information System Cognitive Abilities; Patient-Reported Outcomes Measurement In |
| NCT06679218 | Improving Health Status in COVID-19 Long-Hauler Through an Activity Coaching Programme: a Randomized Control Trial | NOT_YET_RECRUITING | nan | Universidad de Granada | IPAQ (International Physical Activity Questionnaire); EQ-5D (EuroQol-5 Dimensions); PROMIS (Patient-Reported Outcomes Measurement Information System) | nan |
| NCT05975034 | Investigation of the Use of a Probiotic Supplement in People With Long COVID | UNKNOWN | nan | Sheffield Hallam University | Fatigue severity scale (FSS); FACIT fatigue scale; EQ-5D-5L; Ability to Participate in Social Roles and Activities - PROMIS Short Form 8a; Ecological Momentary Assessment (EMA) app | IBS-SSS; Gastrointestinal Symptom Rating Scale; MRC Dyspnoea scale; International. Physical Activity Questionnaire (short form); Accelerometery data; Cambridge Neuropsychological Test Automated Battery (CANTAB); 16S rRNA sequencing; Analysis of inflammatory ma |
| NCT ID | Title | Status | Phase | Sponsor | Primary endpoint | Secondary endpoint |
|---|---|---|---|---|---|---|
| NCT05633407 | A Phase 2 Randomized, Double-blinded, Placebo-controlled Study to Evaluate the Efficacy and Safety of Efgartigimod IV in Adult Patients With Post-COVID-19 Postural Orthostatic Tach | COMPLETED | PHASE2 | argenx | Change From Baseline to Week 24 in the COMPASS 31 (2-week Recall Version); Change From Baseline to Week 24 in the MaPS; Number of Participants With TEAEs and TESAEs | Percentage of Participants With Improved PGI-S at Week 24; Percentage of Participants With Improved in PGI-C at Week 24; Change From Baseline to Week 24 in the PROMIS Fatigue Short Form 8a; Change From Baseline to Week 24 in the PROMIS Cognitive Function Short |
| NCT05592418 | A Randomized, Double Blind, Placebo Controlled Study to Evaluate the Efficacy and Safety of Ampligen® in Patients With Post-COVID Conditions | COMPLETED | PHASE2 | AIM ImmunoTech Inc. | Change From Baseline to Week 13 in PROMIS Fatigue Score (T-Score) | Change From Baseline to Week 6 in PROMIS Fatigue Score (T-Score); Change From Baseline to Week 13 in PROMIS Fatigue Score (T-Score), Excluding Response to Item Seven; Change From Baseline to Week 6 and Week 13 in Distance Traveled During 6-minute Walk Test (6M |
| NCT05576662 | Selective Trial Of Paxlovid for PASC (STOP-PASC): Randomized Double-Blind Placebo-Controlled Pilot Trial of Paxlovid for the Treatment of PASC | COMPLETED | PHASE2 | Stanford University | Number of Participants With No, Mild, Moderate, or Severe Symptoms at Week 10 According to the Core Symptoms Severity Scale Score | Number of Participants With No, Mild, Moderate, or Severe Symptoms at Day 15 According to the Core Symptoms Severity Scale Score; Number of Participants Reporting Relief of at Least One Core Symptom for 2 Weeks; Number of Participants With Overall Alleviation |
| NCT04141696 | A Proof-of-Concept Trial on the Effect of Ketamine on Fatigue | COMPLETED | PHASE1; PHASE2 | National Institute of Nursing Research (NINR) | Percentage Change in Self-reported Fatigue Visual Analog Scale (VAS) Scale | Percentage Change in Self-reported Fatigue Visual Analog Scale (VAS) Scale - Day 7; Areas Under the Curve (AUC) for Percentage Changes in Self-reported Fatigue VAS Score - Through Day 7; Mean Physical Activity Count Using Actigraphy; Fatigue Level Measured by |
| NCT05472090 | A Phase 2, 14-week Double-Blind, Randomized, Multicenter, Placebo-Controlled Study to Evaluate the Efficacy and Safety of TNX-102 SL Taken Daily at Bedtime in Patients With Multisi | COMPLETED | PHASE2 | Tonix Pharmaceuticals, Inc. | Daily Diary Pain NRS | Daily Diary Sleep Quality NRS; PROMIS Fatigue -Short Form 8a; PROMIS Cognitive Function - Abilities-Short Form 8a |
| NCT06136871 | Cognitive Strategy Training in Post-COVID-19 Syndrome: A Feasibility Trial | COMPLETED | nan | University of Missouri-Columbia | Recruitment Rate; Retention Rate; Telehealth Usability Questionnaire (TUQ); Acceptability of Intervention Measure (AIM); Intervention Appropriateness Measure (IAM); Feasibility of Intervention Measure (FIM); Canadian Occupational Performance Measure (COPM) Per | Delis-Kaplan Executive Function System (DKEFS)- Color-Word Interference, Age-Corrected Time; Delis-Kaplan Executive Function System (DKEFS)- Color-Word Interference, Age-Corrected Errors; Patient-Reported Outcomes Measurement Information System (PROMIS) Cognit |
| NCT06476496 | Pain Relief With Integrative Medicine (PRIMe)?: Feasibility of Acupuncture for Long COVID | COMPLETED | nan | University of Washington | Pain, Enjoyment and General Activity (PEG) | Pain Catastrophizing Scale (PCS) Short Form; PROMIS-29; PROMIS Cognitive Function; UW Pain Related Self-Efficacy Scale (PRSE) |
| NCT05877508 | An Exploratory, Randomized, Double-Blind Placebo-Controlled Study to Assess the Safety of an Anti-SARS-CoV-2 Monoclonal Antibody and Response to Treatment in Individuals With Long | ACTIVE_NOT_RECRUITING | PHASE2 | Michael Peluso, MD | Patient-Reported Outcomes Measurement Information System (PROMIS)-29 Physical Health Summary Score | Patient-Reported Outcomes Measurement Information System (PROMIS)-29 Physical Health Summary Score; Patient-Reported Outcomes Measurement Information System (PROMIS)-29 Mental Health Summary Score; Patient-Reported Outcomes Measurement Information System (PROM |
| NCT06161688 | Placebo-Controlled, Randomized Trial of Ensitrelvir (S-217622) for Viral Persistence and Inflammation in People Experiencing Long COVID (PREVAIL-LC) | ACTIVE_NOT_RECRUITING | PHASE2 | Timothy Henrich | Patient-Reported Outcomes Measurement Information System (PROMIS)-29 Physical Health Summary Score | Patient-Reported Outcomes Measurement Information System (PROMIS)-29 Physical Health Summary Score; Patient-Reported Outcomes Measurement Information System (PROMIS)-29 Mental Health Summary Score; Patient-Reported Outcomes Measurement Information System (PROM |
| NCT05445427 | Outcomes of Treatment With Vagal Nerve Stimulation in Post-COVID Syndrome: A Pilot Study | COMPLETED | nan | Mayo Clinic | Change in Post-COVID Functional Status Score | Change in PROMIS Fatigue Scale T Score |
| NCT06208163 | Psychoneuroimmunology as a Framework for Studying the Effects of Chiropractic Care in a Population With High Central Adiposity: a Pilot Trial | COMPLETED | nan | Life University | Proportion of Potential Participants Who Are Eligible.; Proportion of Participants Complying With Pre-baseline Lifestyle Restrictions; Proportion of Participants Able to Tolerate the Assessments; Proportion of Participants Adhering to Their Prescribed Care Pla | Changes in COMPASS-31 Raw Scores; Changes in PSS-10 T-scores; Changes in PROMIS-Cog 8 T-scores; Changes in PROMIS-29 Subscale T-scores; Changes in PROMIS-29 Subscale Raw Scores; Changes in RMSSD; Changes in PEP; Changes in sIgA |
| NCT05918978 | Open-Label Extension Study to Evaluate the Long-term Safety and Efficacy of Efgartigimod in Adult Patients With Post-COVID-19 Postural Orthostatic Tachycardia Syndrome (PC-POTS) Wh | TERMINATED | PHASE2 | argenx | Number of Participants With TEAEs, TESAEs and TEAESIs | Change From Baseline to Weeks 24 and 48 in the COMPASS 31 (2-week Recall Version); Change From Baseline to Weeks 24 and 48 in the MaPS; Percentage of Participants With Improved PGI-S at Weeks 24 and 48; Percentage of Participants With Improved PGI-C at Weeks 2 |
| NCT05638633 | Prednisolone and Vitamin B1, B6, and B12 in Patients With Post-COVID-19-Syndrome (PC19S) - a Randomized Controlled Trial in Primary Care | COMPLETED | PHASE3 | Wuerzburg University Hospital | Pilot phase: Proportion of participants retained after 28 days; Confirmatory phase: Mean difference in PROMIS Total Score from day 0 to day 28 | PROMIS total and subscores; Measure Yourself Medical Outcome Profile (MYMOP); Overall assessment of functional status; PC19 symptom list; EQ-5D-5L; visual analogue scale; PHQ 8; Chalder Scale; Numeric rating scale for pain; Testbatterie zur Aufmerksamkeitsprüf |
| NCT05524532 | Effect of Immulina Supplements on Inflammatory Biomarkers Correlated With Clinical Symptoms in Patients With Long COVID (PASC) | COMPLETED | PHASE3 | University of Mississippi Medical Center | Plasma IL-6 (Interleukin 6, pg/mL); Plasma CRP (C-Reactive Protein, ng/mL); Plasma D-Dimer, pg/mL | PROMIS-29; FSS; SBQ-LC TM; SARS-CoV-2-specific antibody responses; SARS-CoV-2-specific immune responses on memory T cell levels; SARS-CoV-2-specific immune responses on memory B cell levels; Natural Killer cell (NK)-mediated cytotoxicity; Natural Killer (NK) c |
| NCT06404112 | RECOVER-SLEEP: A Platform Protocol for Evaluation of Interventions for Sleep Disturbances in Post-Acute Sequelae of SARS-CoV-2 Infection (PASC) | COMPLETED | PHASE2 | Duke University | Change in total score of the PROMIS 8b SD to assess sleep disturbance; Change in sleep onset variability, assessed using a wearable device | Change in total score of the PROMIS 8a SRI to assess sleep-related impairment; Change in PROMIS 10a Fatigue score; Change in an objective neurocognitive battery score; Change in ECog2 measure; Change in PASC Symptom Questionnaire responses; Change in total sco |
| NCT05668091 | An Interventional Decentralized Phase 2, Randomized, Double-Blind, 2-Arm Study to Investigate the Efficacy and Safety of Orally Administered Nirmatrelvir/Ritonavir Compared with Pl | COMPLETED | PHASE2 | Harlan M Krumholz | National Institutes of Health (NIH) Patient-Reported Outcomes Measurement Information System (PROMIS)-29 version 2.1 Physical Health Summary Score | Modified General Symptom Questionnaire-30 (Modified GSQ-30); PROMIS® Cognitive Function v.2.0 - Short Form 6a; COVID Core Outcome Measure for Recovery; EuroQol EQ-5D-5L Utility Score-VAS (USA Version); Functional Assessment of Chronic Illness Therapy (FACIT)-I |
| NCT06404099 | RECOVER-SLEEP: A Platform Protocol for Evaluation of Interventions for Sleep Disturbances in Post-Acute Sequelae of SARS-CoV-2 Infection (PASC) | COMPLETED | PHASE2 | Duke University | Change in total score of the PROMIS 8a SRI to assess sleep-related impairment | Change in total score of the PROMIS 8b SD to assess sleep disturbance; Change in PROMIS 10a Fatigue score; Change in an objective neurocognitive battery score; Change in ECog2 measure; Change in PASC Symptom Questionnaire responses; Change in total score on th |
| NCT06305806 | RECOVER-AUTONOMIC (Ivabradine): Randomized Trial of the Effect of Ivabradine Versus Placebo on Long COVID Symptoms | COMPLETED | PHASE2 | Kanecia Obie Zimmerman | Change in Orthostatic Hypotension Questionnaire (OHQ)/Orthostatic Intolerance Questionnaire (OIQ) Composite Score | Change in Composite Autonomic Symptoms Score 31 (COMPASS-31); Change in Malmo POTS Symptom Score; Change in heart rate (HR); Change in 6-min Walk Test; Change in PROMIS-29 + 2 Questionnaire; Characterize the safety and tolerability of study intervention for tr |
| NCT07492953 | Using Enhanced External Counterpulsation to Recover Cardiovascular Function for Patient of Chronic Diseases | COMPLETED | nan | National Defense Medical Center, Taiwan | Peak oxygen uptake (Peak VO₂) | The Six-Minute Walk Test (6MWT); Blood Pressure and Heart Rate; PROMIS Physical Health score; PROMIS Mental Health Score; PROMIS Sleep Disturbance Domain; Seattle Angina Questionnaire-7 (SAQ-7) summary score; COPD Assessment Test (CAT) score; Rose Dyspnea Scal |
| NCT06404073 | RECOVER-ENERGIZE: A Platform Protocol for Evaluation of Interventions for Exercise Intolerance in Post-Acute Sequelae of SARS-CoV-2 Infection (PASC) | COMPLETED | nan | Duke University | Change in frequency of PEM symptoms, as measured by the Modified DePaul Symptom - Post-Exertional Malaise questionnaire (mDSQ-PEM); Change in severity of PEM symptoms, as measured by the Modified DePaul Symptom - Post-Exertional Malaise questionnaire (mDSQ-PEM | Change in PASC symptoms, as measured by the PASC Symptom Questionnaire; Change in PASC symptoms, as measured by the PROMIS-Cog Questionnaire; Change in quality of life, as measured by the PROMIS-29+2; Change in quality of life, as measured by the EQ-5D 5L; Cha |
| NCT06974058 | Evaluation of a Quercetin/Curcumin-Based Supplement for Mild to Moderate Long COVID-19 Symptoms: A Pragmatic, Interventional Clinical Study. | COMPLETED | nan | Liaquat University of Medical & Health Sciences | Change in Overall Symptom Burden | Change in Functional Status and Quality of Life (SF-36 Scores); Change in the Need for Prescribed Medications or NSAIDs (Non-Steroidal Anti-Inflammatory Drugs); Change in Pain Severity and Pain Interference (Brief Pain Inventory - Short Form); Change in Fatigu |
| NCT05218174 | Exercise Training and Functional, Cognitive, and Emotional Well-being in Adults with Post-Acute Sequelae of SARS-CoV-2 (COVID-19) Infection (PASC): a Randomized Controlled Trial | COMPLETED | nan | Baylor Research Institute | Peak Oxygen Consumption (VO2max), mL/min; Peak Oxygen Consumption (VO2max), mL/min; Peak Oxygen Consumption (VO2max), mL/min; Score on Cognitive Function Self-Assessment Scale (CFSS); Score on Cognitive Function Self-Assessment Scale (CFSS); Score on Cognitive | Duration, mm:ss; Duration, mm:ss; Duration, mm:ss; Peak VO2 (absolute), mL/min; Peak VO2 (absolute), mL/min; Peak VO2 (absolute), mL/min; Peak VO2 (relative), mL/kg/min; Peak VO2 (relative), mL/kg/min; Peak VO2 (relative), mL/kg/min; Metabolic Equivalents; Met |
| NCT06330376 | Diaphragmatic Breathing Exercises for Post-COVID-19 Diaphragmatic Dysfunction (DD) | COMPLETED | nan | University of Minnesota | 6-minute walk test (6MWT) | PHQ9: Patient health questionnaire 9; GAD7: Generalized anxiety disorder 7-item; PROMIS score: Patient-Reported Outcomes Measurement Information System; QoL scale: Quality of life scale; FACIT fatigue scale 's Fatigue score; Modified Borg dyspnea scale; R |
| NCT05710770 | Double-blinded, Randomized, Sham-controlled Trial of Immunoadsorption (IA) in Patients With Chronic Fatigue Syndrome (CFS) Including Patients With Post-acute COVID-19 CFS (PACS-CFS | COMPLETED | nan | Charite University, Berlin, Germany | Improvement in physical and mental fatigue as measured by the Chalder Fatigue Scale | Sustained improvement quantified by the Chalder Fatigue Scale; Verification of safety and tolerability of immunoadsorption in this patient population; Improvement in severity of symptoms of chronic fatigue syndrome (CFS) as measured by the Fluge score; Improve |
| NCT05965739 | RECOVER-NEURO: A Platform Protocol for Evaluation of Interventions for Cognitive Dysfunction in Post-Acute Sequelae of SARS-CoV-2 Infection (PASC) | COMPLETED | nan | Duke University | Change in Everyday Cognition 2 (ECog2) | Change in PROMIS-cognitive function - short form 8a (PROMIS-Cog) total score; Change on an objective neurocognitive battery scores; Change in Everyday Cognition 2 (ECog2); Characterize the intervention's safety as measured by the proportion of Serious Adv |
| NCT06590324 | A Phase II, Multi-centre Open Label Study to Assess the Efficacy and Safety of Oral Apabetalone With Background Dapagliflozin in Subjects With Long -COVID-19 (Post-COVID-19 Conditi | RECRUITING | PHASE2; PHASE3 | Resverlogix Corp | patient acceptable symptom state (PASS) | Long COVID Symptom and Impact tools (LCST/LCIT); Patient-Reported Outcomes Measurement Information System (PROMIS)-Fatigue Short Form 7a (SF-7a); Baseline Dyspnea Index (BDI) & Transition Dyspnea Index (TDI); Post-COVID-19 Functional Status (PCFS) Scale; D |
| NCT06305793 | RECOVER-AUTONOMIC (IVIG): Randomized Trial of the Effect of IVIG Versus Placebo on Long COVID Symptoms | ACTIVE_NOT_RECRUITING | PHASE2 | Kanecia Obie Zimmerman | Change in Orthostatic Hypotension Questionnaire (OHQ)/Orthostatic Intolerance Questionnaire (OIQ) Composite Score | Change in Composite Autonomic Symptoms Score 31 (COMPASS-31); Change in Malmo POTS Symptom Score; Change in Active Stand Test; Change in blood pressure; Change in heart rate (HR); Change in 6-min Walk Test; Change in Patient-Reported Outcomes Measurement Infor |
| NCT06960928 | Low Dose Sirolimus in People With Post-Acute Sequelae of COVID-19 (PASC) Long COVID-19 | RECRUITING | PHASE3 | Icahn School of Medicine at Mount Sinai | European Quality of Life-Visual Analogue Scale (EQ-VAS) | The EuroQol Five-Dimensional Health Questionnaire (EQ-5D-5L); Patient-Reported Outcomes Measurement Information System 29 (PROMIS-29); General Symptom Questionnaire (GSQ-30); Patient Health Questionnaire (PHQ-9); Generalized Anxiety Disorder (GAD-7); Neuro-QoL |
| NCT06928272 | LC-REVITALIZE - A Long Covid Repurposed Drug Study | RECRUITING | PHASE3 | Douglas D. Fraser | Symptom Burden Questionnaire (SBQ) Subscales | General participant reported overall well-being using the Patient Reported Outcome Measurement Information System (PROMIS)-29 questionnaire; General participant reported overall well-being using the Generalized Anxiety Disorder (GAD)-7 questionnaire; General p |
| NCT05697042 | A Mobile Intervention Merging Yoga and Self-Management Skills (MY-Skills Mobile) for Individuals Experiencing Symptoms of Long COVID-19 | COMPLETED | nan | University of Colorado, Denver | Feasibility- Recruitment; Feasibility- Use; Feasibility- Attrition; Feasibility-Usability | Symptom Burden Scale for Long COVID; PROMIS Fatigue; Brief Pain Inventory; Short Form 36 |
| NCT06172803 | RESToRE: Restoring Energy With Sub-symptom Threshold Optimized Rehabilitation Exercise for Long COVID | COMPLETED | nan | Columbia University | Number of participants who enrolled; Number of participants who completed; Number of participants who adhered to session attendance | PROMIS-29 scale score; Rand 36-Item Health Survey (SF-36) score; VO2 % predicted from Cardiopulmonary Exercise Testing (CPET); Number of participants with orthostatic hypocapnia.; EuroQol: Education Quotient-5D Visual Analogue Scale score; General Symptom Ques |
| NCT04827992 | Evaluation of Medical Cannabis and Prescription Opioid Taper Support for Reduction of Pain and Opioid Dose in Patients With Chronic Non-Cancer Pain | COMPLETED | nan | Massachusetts General Hospital | Mean Difference in Prescription Monitoring Program verified opioid dose at baseline and week 24; Mean Difference in Pain, Enjoyment, General Activity (PEG) Scale Summed Score over post-baseline to week 24 interval | Mean Difference in Quality of Life Enjoyment and Satisfaction Questionnaire - Short Form Summed Score at weeks 4, 8, 12, 16, 20, 24; Mean Difference in PROMIS-29 Depression Subscale Summed Score at weeks 4, 8, 12, 16, 20, 24; Mean Difference in PROMIS-29 Anxie |
| NCT06631287 | Randomized Double-Blind Placebo-Controlled Trial EValuating Baricitinib on PERSistent NEurologic and Cardiopulmonary Symptoms of Long COVID (REVERSE-LC) | RECRUITING | PHASE3 | Wes Ely | CNS-Vital Signs Global Cognitive Index | Objective neuropsychological function domains of executive function, memory, processing speed, and motor speed including the CNS-Vital Signs subscale tests at 6-months.; Objective neuropsychological function domains of executive function, memory, processing sp |
| NCT05225220 | Multimodal Investigation of Post COVID-19 in Females: A Pilot Study | COMPLETED | nan | Casa Colina Hospital and Centers for Healthcare | Change in Flanker Inhibitory Control and Attention Test (Flanker) scores; Change in Picture Sequence Memory Test (PSMT) scores; Change in Dimensional Change Card Sort Test (DCCS) scores; Change in Pattern Comparison Processing Speed scores; Change in List Sort | Change in Magnetic Resonance Imaging (MRI); Change in resting state Electroencephalograph (EEG) signals; Change in blood marker levels; Change in BURNS Anxiety Inventory scores; Change in Becks Depression Inventory (BDI) scores; Change in PROMIS Sleep Disturba |
| NCT06847191 | A Double-blind, Randomized Study to Evaluate the Efficacy and Safety of Bezisterim (NE3107) in Adults With Long COVID | ACTIVE_NOT_RECRUITING | PHASE2 | BioVie Inc. | Change from Baseline in performance on the Cogstate Cognition battery* | Change from Baseline in PROMIS Cognitive Function Short Form 8a (SF-8a); Change from Baseline in PROMIS Fatigue Short Form 13a (SF-13a); Change from Baseline in PROMIS Sleep Disturbance Short Form 8a (SF-8a); Change from Baseline in SF-12 Health Survey (Physic |
| NCT06404060 | RECOVER-ENERGIZE: A Platform Protocol for Evaluation of Interventions for Exercise Intolerance in Post-Acute Sequelae of SARS-CoV-2 Infection (PASC) | ACTIVE_NOT_RECRUITING | nan | Duke University | Change in Endurance Shuttle Walk Test (ESWT) | Change in physical function, as measured by the PROMIS SF-Physical Function (PROMIS-PF); Change in physical function, as measured by actigraphy; Change in symptom frequency, as measured by the Modified DePaul Symptom Questionnaire - Post-Exertional Malaise (mD |
| NCT06391489 | Piloting A Telehealth Deliverable Self-Management and Cognitive Training Program (HOBSCOTCH, HOme Based Self-Management and COgnitive Training CHanges Lives) for People With Post A | ACTIVE_NOT_RECRUITING | nan | Dartmouth-Hitchcock Medical Center | Change in overall quality of life as measured by comparing PROMIS-10 Global Health scores pre- and post-HOBSCOTCH-PACS intervention.; Change in subjective cognition as measured by comparing Neuro-QOL Item Bank v2.0 Cognitive Function scores pre- and post-HOBSC | Change in objective cognition as measured by comparing Symbol-Digit Modalities Test scores pre- and post-HOBSCOTCH-PACS intervention.; Change in objective cognition as measured by comparing California Verbal Learning Test-III scores pre- and post-HOBSCOTCH-PAC |
| NCT06974084 | A Multi-Center Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy of Maraviroc and Atorvastatin for the Treatment of Subjects With Long COVID/Post-Acute Se | NOT_YET_RECRUITING | PHASE2; PHASE3 | HealthBio, Inc. | Fatigue | Improvement in dysautonomia symptoms as reflected by the Composite Autonomic Symptom Score (COMPASS-31); Improvement in Dyspnea; Improved Cognitive Function, measured by the PROMIS (Patient-Reported Outcomes Measurement Information System) Cognitive Function v |
| NCT06821087 | Evaluating the Neuromodulatory Effect of Ketamine in Long COVID: A Pilot Study Targeting Fatigue and Neurocognitive Symptoms | ENROLLING_BY_INVITATION | PHASE2 | University of Texas at Austin | PROMIS SF v1.0 - Fatigue 8a; PROMIS SF v2.0 Cognitive Function 4a; BrainCheck Cognitive Battery; Number of participants with treatment-related adverse events as assessed by standardized interview | PROMIS Global 10 v1.2; NASA Task Load Index (NASA-TLX); Patient Health Questionnaire-9 (PHQ-9); Generalized Anxiety Disorder-7 (GAD-7); Depression in Medically Ill 10 Scale (DMI-10); Long COVID Review of Systems; Neuroimaging (MRI) Outcomes; Serum Biomarker An |
| NCT06739720 | A Randomized, Waitlist-controlled Clinical Study on the Efficacy and Safety of Lingzhi-containing Dietary Supplement CP003 on Chronic Fatigue and Post-COVID Fatigue | NOT_YET_RECRUITING | PHASE2; PHASE3 | The University of Hong Kong | Mean difference in Chalder Fatigue Score | Mean difference in Chalder Fatigue Score; Mean difference in 36-Item Short-Form Health Survey; Mean difference in Fatigue Severity Score; mean difference in (PROMIS) Short Form Fatigue 7A survey; Mean difference in hospital anxiety and depression scale; Mean d |
| NCT06511063 | Investigating the Feasibility of Repurposing HIV Antivirals in Adults With Long Covid | RECRUITING | PHASE2 | Icahn School of Medicine at Mount Sinai | EuroQol 5-Dimension 5-Level (EQ-5D-5L) Visual Analogue Scale | The EuroQol Five-Dimensional Health Questionnaire (EQ-5D-5L); Patient-Reported Outcomes Measurement Information System 29 (PROMIS-29); General Symptom Questionnaire (GSQ-30); Patient Health Questionnaire (PHQ-9); Generalized Anxiety Disorder (GAD-7); Neuro-QoL |
| NCT07316127 | A Placebo-Controlled, Double-Blind, Randomized Trial Phase I-II With Immunoadsorption in Autoimmune Long COVID | RECRUITING | PHASE2 | Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) | Change in fatigue measured by the Fatigue Assessment Scale (FAS) | Change in health related quality of life using the 36-Item Short Form Health Survey (SF-36); Change in cognitive functioning using the Patient-Reported Outcomes Measurement Information System (PROMIS®) Cognitive Function Short Form 8a (PROMIS Cognitive Functio |
| NCT06586398 | A Pilot Randomized Trial of rTMS for Fatigue and Brain Fog and Neuropsychiatric Symptoms of Long-COVID. | ACTIVE_NOT_RECRUITING | nan | University of California, Los Angeles | Tolerability as measured by Safteesi survey; Safety profile and adverse events | Subjective Cognitive impairment assessed by Multidimensional Inventory of Subjective Cognitive Impairment (MISCI); Fatigue assessed by Fatigue Severity Scale (FSS); Physical and mental health assessed by PROMIS-29; Alzheimer's Disease Assessment Scale (AD |
| NCT07108036 | Interleukin-15 Superagonist Nogapendekin Alfa Inbakicept in Participants With Long Covid. | RECRUITING | PHASE2 | ImmunityBio, Inc. | Incidence of treatment emergent adverse events (TEAEs) through 30 days post final study drug administration.; Incidence of grade 3 or higher TEAEs through 30 days post final study drug administration.; Incidence of serious adverse events (SAEs) through 30 days | Change in the ALC from Screening, INT1, FU1.3, INT2, FU2.3, FU2.4, FU2.5, and EOS.; Change in patient-reported outcomes (PROs) PROMIS-29 score from Baseline to FU2.5 (45 days following last NAI administration).; Change in other assessments (eg, EuroQoL Quality |
| NCT06366724 | LIFT: Life Improvement Trial | RECRUITING | PHASE2 | Brigham and Women's Hospital | Functional Capacity; Physiologic Response - Oxygen Uptake Efficiency Slope (OUES); Physiologic Response - Oxygen Utilization (VO2); Physiologic Response - Heart Rate Recovery (HRR) | Post-Exertional Malaise; PROMIS-29-Pain; Daily Activity; Heart Rate Variability; Blood Oxygen; Resting Heart Rate; DANA Brain Vital-Simple Reaction Time (SRT); DANA Brain Vital-Procedural Reaction Time (PRT); DANA Brain Vital-Memory Search (MS) |
| NCT06766825 | Phase II Proof-of-concept, Randomized, Double-blind, Placebo-controlled Study to Evaluate the Efficacy and Safety of Plitidepsin in Adults With Post-COVID-19 Condition (PCC) | RECRUITING | PHASE2 | Fundación FLS de Lucha Contra el Sida, las Enfermedades Infecciosas y la Promoción de la Salud y la Ciencia | Change in the overall health in patients from each group using patient reported outcomes measurement information system score (PROMIS-29®). | To compare the safety/tolerability of Plitidepsin Vs placebo in terms of adverse events in patients with PCC.; To compare the incidence of Treatment-Emergent Adverse Events (TEAEs) between groups.; To compare changes in the overall health in patients from each |
| NCT05167227 | The Long COVID and Fatiguing Illness Recovery Program - A Pragmatic, Quality Improvement, Professional Cluster, Randomized Controlled Trial. | ACTIVE_NOT_RECRUITING | nan | Family Health Centers of San Diego | Patient-Reported Outcomes Measurement Information System (PROMIS)-29 | Patient symptom checklist with associated severity for those present; If symptom is present, has patient experienced this in the past month; If symptom is present, how long has patient experienced this symptom; If symptom is present, did patient have this symp |
| NCT07021794 | Effectiveness of Treating Post-COVID-19 Conditions (Long COVID) With the SARS-CoV-2 Specific Monoclonal Antibody, Sipavibart | RECRUITING | PHASE2 | Nancy Klimas | Patient-Reported Outcomes Measurement Information System-29; Review of Treatment Related Adverse Events | Symptom-specific participant-reported outcome measures; Change in Simple Reaction Time (Milliseconds); Self-reported fatigue using MFI; Change in Heart Rate Post-6MWT; Processing Speed; Attention; Systolic Blood Pressure Response During NASA Lean Test; Diastol |
| NCT06865222 | Variable Pulse Transcranial Magnetic Stimulation for Treatment of Post COVID Syndrome | RECRUITING | nan | Mayo Clinic | Change in University of Pennsylvania Smell Identification Test (UPSIT) Olfactory Threshold Test score; Change in Tinnitus Handicap Inventory Scale score; Change in Modified Fatigue Impact Scale score | Change in General Anxiety Disorder-7 (GAD-7) score; Change in Patient Health Questionnaire-9 score; Change in PROMIS Global-10 score; Change in alpha wave characteristics measured via EEG.; Number of serious adverse events (SAEs) |
| NCT07140094 | Long-Covid-19 Alleviation Through Learning Mindfulness Study (LONG-CALM) | RECRUITING | nan | Columbia University | Mean Score of Patient-Reported Outcomes Measurement Information System (PROMIS) Global 10 Score | Change in PROMIS Global 10 Score; Post-Acute Sequelae of SARS-CoV-2 (PASC) Score; Patient Health Questionnaire 9 (PHQ9) Score; Generalized Anxiety Disorder 7 (GAD7) Score; Impact of Event 6 (IES-6) Scores; State Mindfulness Scale for Physical Activity Score; D |
| NCT07585513 | A Randomized Placebo-Controlled Clinical Trial Evaluating Mirabegron's Effectiveness in Alleviating POTS Symptoms | NOT_YET_RECRUITING | PHASE2 | Cedars-Sinai Medical Center | Self-reported frequencies of cardiac-related symptoms as recorded by the number of pushbutton events per day on the monitor. | Malmö POTS Symptom Score; EQ-5D-5L quality of life score; Duke Activity Status Index; Seattle Angina Questionnaire score; OAB-q SF; PROMIS survey; skin sympathetic nerve activity (SKNA) parameters |
| NCT06611111 | Phase 1, Randomized, Double-Blind, Placebo-Controlled Trial of Pulse Dosed Ceftriaxone for Post-Treatment Lyme Disease | RECRUITING | EARLY_PHASE1 | State University of New York - Upstate Medical University | Number of abnormal laboratory measurements; Intensity of Abnormal Laboratory Measurements; Duration of Abnormal Laboratory Measurements; Occurrence of adverse events; Intensity adverse events; Duration of adverse events; Number of serious adverse events | Fatigue Severity Scale; SAFTEE assessment; SF-36 continuous variables; SF-36 Responder-Nonresponder; General Symptom Questionnaire; PROMIS-29; Lyme VlsE1/pepC10 Antibody |
| NCT06045338 | Mind Body Intervention for Long COVID | RECRUITING | nan | Beth Israel Deaconess Medical Center | Somatic Symptom Score-8 (SSS-8) | Short Form Brief Pain Inventory (BPI); Fatigue Severity Scale (FSS); The Multidimensional Dyspnea Profile (MDP); Generalized Anxiety Disorder form 7 (GAD-7); Patient Reported Outcomes Measurement Information System survey for function disability (PROMIS); End |
| NCT07278206 | Mitigating Cognitive Problems and Fatigue With Brain Stimulation in Long COVID | RECRUITING | nan | Amsterdam UMC, location VUmc | Fatigue | Objective cognitive functioning; Arterial Spin Labeling (ASL); Magnetic Resonance Spectroscopy (MRS); Functional Magnetic Resonance Imaging (fMRI); Actigraphy; Short physical performance battery (SPPB); Simple Reaction Time (SRT); Effort-based decision task; N |
| NCT06915324 | Transcranial Direct Current Stimulation (tDCS) of Brain Fog in Patients With Post Treatment Lyme Disease | RECRUITING | nan | Columbia University | Coding test scale score for acute treatment; Coding test scale score for post-treatment follow-up | Composite score of the reaction time measures; Fatigue Severity Scale (FSS) Score; General Symptom Questionnaire (GSQ-30) Score; Generalized Anxiety Disorder-7 (GAD-7) Score; PROMIS Emotional Distress-Depression-Short Form Score; Patient-Reported Outcomes Meas |
| NCT07285707 | Acupuncture for Long COVID - A Pragmatic Pilot Study | RECRUITING | nan | Southern California University of Health Sciences | Feasibility of Implementing a Combined Acupuncture and Chinese Herbal Medicine Intervention for long COVID | Patient-Reported Acceptability of the Study Procedures and Treatments; Clinician-Reported Acceptability of the Study Protocol; Change in Health-Related Quality of Life Measured by PROMIS-29 v2.1; Change in Symptom Burden Measured by the Symptom Burden Question |
| NCT05931497 | A Pilot Study of Whole Body Hyperthermia for Long Covid or Post-Acute Sequelae of COVID-19 (PASC) | RECRUITING | nan | Massachusetts General Hospital | The Patient Reported Outcome Measurement Information System Fatigue-Short Form v1.0 -Fatigue 7a (PROMIS F-SF) | Patient-Reported Outcomes Measurement Information System (PROMIS-29); Patient Health Questionnaire-9 (PHQ); The Perceived Stress Scale (PSS); Patient-Reported Outcomes Measurement Information System Cognitive Abilities; Patient-Reported Outcomes Measurement In |
| NCT07597902 | SARS-CoV-2 and Herpesvirus Inhibition for Ending Long COVID Dysfunction (SHIELD) | NOT_YET_RECRUITING | PHASE2 | Icahn School of Medicine at Mount Sinai | EQ-5D-5L Visual Analogue Scale (VAS) | The EuroQol Five-Dimensional Health Questionnaire (EQ-5D-5L); Patient-Reported Outcomes Measurement Information System 29 (PROMIS-29); General Symptom Questionnaire (GSQ-30); Patient Health Questionnaire (PHQ-9); Generalized Anxiety Disorder (GAD-7); COLUMBIA- |
| NCT05986422 | Phase 2a, Double-blind, Randomized, Placebo-controlled Trial of Methylprednisolone Versus Placebo in Patients With Cognitive Deficits in Post-COVID-19 Syndrome (PCS) | TERMINATED | PHASE2 | Charite University, Berlin, Germany | Improvement in memory satisfaction as measured by the Multifactorial Memory Questionnaire (MMQ) | Long-term improvement in memory satisfaction as measured by the Multifactorial Memory Questionnaire (MMQ); Improvement in memory ability and memory strategy as measured by the Multifactorial Memory Questionnaire; Improvement in neurocognitive functions as meas |
| NCT07600320 | Microtesla Magnetic Therapy (MMT) Treatment of Cognitive Impairment: Open Label Pilot Study | NOT_YET_RECRUITING | nan | Icahn School of Medicine at Mount Sinai | Proportion of participants who complete prescribed device sessions | BrainCheck; Hospital Anxiety and Depression Scale (HADS); PROMIS Sleep Disturbance; Neuro-QoL Cognitive Function (Short Form); PROMIS Fatigue; Patient Global Impression of Change (PGIC); Functional Capacity Assessment (FUNCAP) |
| NCT06953661 | Ultrasound Guided Stellate Ganglion Block in Postural Tachycardia Syndrome: A Randomized Double Blind Sham Placebo-controlled Pilot Study | NOT_YET_RECRUITING | nan | Stanford University | COMPASS 31 total score | Magnitude of postural tachycardia; Heart rate variability (HRV); Plasma catecholamine levels; Survey of Postural Orthostatic Tachycardia Syndrome Symptoms (SPOTS); VOSS score; FSS score; PROMIS Cognitive Function Short Form 6a; EQ-5D score; PGI-S rating; PGI-C |
| NCT06785402 | Phase 1/2, Randomized, Double-Blind, Placebo-Controlled Trial of Pulse Dosed Ceftriaxone for Post-Treatment Lyme Disease | WITHDRAWN | PHASE1; PHASE2 | Hackensack Meridian Health | Safety of pulse-dosed ceftriaxone; Tolerability of pulse-dosed ceftriaxone; Study Feasibility | Clinical Improvement - Physical and mental summary indices; Clinical Improvement - General Symptom Questionnaire (GSQ-30); Clinical Improvement - PROMIS-29; Clinical Improvement - Quantitative Lyme VlsE1/pepC10 Ab |
| NCT05346120 | Post-Acute COVID-19, Inflammation, and Depression | WITHDRAWN | PHASE2 | Sean Savitz | Quick Inventory of Depressive Symptomatology (QIDS-SR) | PROMIS |
| NCT05618067 | The Impact of Improved Vagal Function on Periaqueductal Gray Connectivity | NOT_YET_RECRUITING | nan | Virginia Commonwealth University | Change in periaqueductal gray region (PAG) activation - looming task; Change in PAG activation - resting; Change in Heart Rate Variability (HRV) | Change in Fatigue Severity Scale (FSS) score from baseline; Change in Generalized Anxiety Disorder Scale (GAD-2) score from baseline; Differences in Adverse Childhood Experiences (ACE) scores between participants; Change in Pain Catastrophizing Scale (PCS) sco |
| NCT05947617 | Phase 1 Study: Assessing VIX001 Safety, Efficacy, and Dosing in Post Acute COVID-19 Syndrome (PACS) Patients With Neurological Symptoms and Cognitive Impairment. | UNKNOWN | PHASE1 | Neobiosis, LLC | Change from Baseline Six Minute Walk Test (6MWT) with oximetry.; Change from Baseline Transthoracic Echocardiogram in 3 Dimensions (3-D TTE).; Change from Baseline Pulmonary Function Test (PFT) with bronchodilation if abnormal.; Change from Baseline Sleep time | PROMIS; mMRC Scale.; General Anxiety Disorder (GAD-7).; Personal Health Questionnaire Depression Scale (PHQ-8). |
| NCT04349605 | Meditation and Yoga for Patients With Persistent Symptoms After Lyme Disease | WITHDRAWN | nan | Research Foundation for Mental Hygiene, Inc. | Fatigue Severity Scale; General Symptom Questionnaire-30; Quality of Life Experience Scale | Pain Visual Analog Scale; Applied Cognition scale; PROMIS-29; SF-12 |
| NCT ID | Title | Status | Phase | Sponsor | Primary endpoint | Secondary endpoint |
|---|---|---|---|---|---|---|
| NCT04141696 | A Proof-of-Concept Trial on the Effect of Ketamine on Fatigue | COMPLETED | PHASE1; PHASE2 | National Institute of Nursing Research (NINR) | Percentage Change in Self-reported Fatigue Visual Analog Scale (VAS) Scale | Percentage Change in Self-reported Fatigue Visual Analog Scale (VAS) Scale - Day 7; Areas Under the Curve (AUC) for Percentage Changes in Self-reported Fatigue VAS Score - Through Day 7; Mean Physical Activity Count Using Actigraphy; Fatigue Level Measured by |
| NCT05472090 | A Phase 2, 14-week Double-Blind, Randomized, Multicenter, Placebo-Controlled Study to Evaluate the Efficacy and Safety of TNX-102 SL Taken Daily at Bedtime in Patients With Multisi | COMPLETED | PHASE2 | Tonix Pharmaceuticals, Inc. | Daily Diary Pain NRS | Daily Diary Sleep Quality NRS; PROMIS Fatigue -Short Form 8a; PROMIS Cognitive Function - Abilities-Short Form 8a |
| NCT05890534 | Pycnogenol® in People With Post-COVID-19 Condition: a Quadruple-blind, Randomized, Placebo-controlled Trial | COMPLETED | PHASE3 | University of Zurich | Health status (EQ-VAS) | Post COVID-19 symptoms; Fatigue; Dyspnea; Cognitive function; Anxiety and depression; Health-related quality of life (EQ-5D-5L); Functional exercise capacity; Physical activity; Soluble Thrombomodulin (sTM); von Willebrand Factor antigen (VWF:Ag); Syndecan-1; |
| NCT06393790 | Health Effects of a Strength Training Protocol in Women With Fibromyalgia and Healthy Individuals. | COMPLETED | nan | Catholic University of Murcia | PRE-TEST Time up and go test (TUG test); PRE-TEST 5 Times Sit to stand test (5TSTS); PRE TEST 10 meters walk test; PRE TEST 2 minutes walk; PRE TEST Upper body dinamometry; PRE TEST Lower body dinamometry; PRE TEST Sleep assessment: Karolinska Sleepiness Diary | ACUTE PRE-TEST Time up and go test (TUG test); ACUTE POST-TEST Time up and go test (TUG test); ACUTE PRE-TEST 5 Times Sit to stand test (5TSTS); ACUTE POST-TEST 5 Times Sit to stand test (5TSTS); ACUTE PRE TEST 10 meters walk test; ACUTE POST TEST 10 meters wa |
| NCT04381780 | Treatment of Fibromyalgia With a Unique Polypeptide Nutritional Support | COMPLETED | nan | Practitioners Alliance Network | Composite VAS | FIQ-R |
| NCT05435456 | Effect of Strengthening and Relaxation Exercises on Musculoskeletal Pain, Anxiety, and Sleep Quality on Post-covid Symptoms | COMPLETED | nan | Halic University | McGill Pain Scale short form (SFMPQ); Short-Form 36 (SF-36); Pittsburg Sleep Quality Index; Beck Anxiety Scale | nan |
| NCT05531019 | COVID-19 Sequelae: Treatment and Monitoring of Persistent Symptoms, a Decentralized Approach Focus on the Patient. Use of Dietary Supplement Based on Sea Urchin Eggs With Echinochr | COMPLETED | nan | Fernando Saldarini | Change of symptoms over time-points (baseline, 4 weeks, 8 weeks, 12 weeks) during rutine medical checkup.; Change of lung capacity over four times (baseline, 4 weeks, 8 weeks, 12 weeks) assessed during spirometry.; Change of walking distance during a six minut | Change of Von Willebrand Factor over time-points (baseline, 4 weeks, 12 weeks, 12 weeks) via blood sample.; Change of D Dimer over time-points (baseline, 4 weeks, 12 weeks, 12 weeks) via blood sample.; Change of HS-CRP over time-points (baseline, 4 weeks, 8 we |
| NCT05793736 | A Feasibility Study of an HVR Protocol Biofeedback Training to Manage Long Covid Syndrome Symptoms | COMPLETED | nan | University of Cagliari | Change from Baseline to 5 weeks and to 9 weeks in Patient Health Questionnaire-9 (PHQ-9) score; Change from Baseline to 5 weeks and to 9 weeks in Brief Fatigue Inventory (BFI) score; Change from Baseline to 5 weeks and to 9 weeks in Short Form Health Survey (S | nan |
| NCT06960928 | Low Dose Sirolimus in People With Post-Acute Sequelae of COVID-19 (PASC) Long COVID-19 | RECRUITING | PHASE3 | Icahn School of Medicine at Mount Sinai | European Quality of Life-Visual Analogue Scale (EQ-VAS) | The EuroQol Five-Dimensional Health Questionnaire (EQ-5D-5L); Patient-Reported Outcomes Measurement Information System 29 (PROMIS-29); General Symptom Questionnaire (GSQ-30); Patient Health Questionnaire (PHQ-9); Generalized Anxiety Disorder (GAD-7); Neuro-QoL |
| NCT06723821 | Effectiveness of Noninvasive Neuromodulation in Post-COVID Musculoskeletal Pain in the Short Term: Randomized Clinical Trial | COMPLETED | nan | University of Alcala | Visual Analogue Scale (VAS) | DN4 scale; Pittsburg Sleep Quality Index score; Hospital Anxiety and Depression Scale (HAND); Quality of life SF12 |
| NCT04827992 | Evaluation of Medical Cannabis and Prescription Opioid Taper Support for Reduction of Pain and Opioid Dose in Patients With Chronic Non-Cancer Pain | COMPLETED | nan | Massachusetts General Hospital | Mean Difference in Prescription Monitoring Program verified opioid dose at baseline and week 24; Mean Difference in Pain, Enjoyment, General Activity (PEG) Scale Summed Score over post-baseline to week 24 interval | Mean Difference in Quality of Life Enjoyment and Satisfaction Questionnaire - Short Form Summed Score at weeks 4, 8, 12, 16, 20, 24; Mean Difference in PROMIS-29 Depression Subscale Summed Score at weeks 4, 8, 12, 16, 20, 24; Mean Difference in PROMIS-29 Anxie |
| NCT06379737 | Valutazione Degli Esiti a Medio-lungo Termine Della Sindrome Long Covid in Pazienti Trattati Con un Protocollo di Riabilitazione in Ambiente Termale o in Teleriabilitazione | COMPLETED | nan | Padua University General Hospital | Numerical Rating Scale (NRS); Hand grip strength; Barthel Dyspnea Scale; Fatigue Assessment Scale; Beck's Depression Inventory (BDI; Beck Anxiety Inventory (BAI); 12-Item Short Form Health Survey (SF-12) | Patients satisfaction |
| NCT05764070 | Impact of Vagus Nerve Stimulation on Post-Aerobic Activity Recovery in Post Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Patients | COMPLETED | nan | Istanbul Medipol University Hospital | Visual Analogue Scale (VAS); Autonomic nervous system device (Polar H10); Lactate Analysis | nan |
| NCT05363514 | A Pilot Study of Low Dose Naltrexone Use in Patients With Postural Orthostatic Tachycardia Syndrome | NOT_YET_RECRUITING | PHASE4 | University of Calgary | Fatigue Visual Analogue Scale (VAS) | RAND 36 Health Related Quality of Life Score; Cytokines |
| NCT06511050 | Investigating the Effects of Lumbrokinase in Adults With Long Covid, Post-treatment Lyme Disease Syndrome, and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome | RECRUITING | PHASE1; PHASE2 | Icahn School of Medicine at Mount Sinai | EuroQol Visual Analogue Scale Score (EQ-VAS) | The EuroQol Five-Dimensional Health Questionnaire (EQ-5D-5L); 10-Meter Walk Test; Root mean square of successive differences between normal heartbeats (RMSSD); BrainCheck Cognitive Assessment Battery; General Symptom Questionnaire (GSQ-30); Medical Research Co |
| NCT07242573 | Evaluation of the Effect of Individualized Physical Training and Neuromodulation on Pain, Sleep and Fatigue in Patients With Fibromyalgia: a Randomized Controlled Trial | RECRUITING | nan | National Institute of Geriatrics, Rheumatology and Rehabilitation, Poland | Change in pain intensity (Visual Analogue Scale - VAS 0-10); Change in sleep quality (Pittsburgh Sleep Quality Index - PSQI) | Change in depressive symptoms (Beck Depression Inventory - BDI); Change in Widespread Pain Index (WPI) and Symptom Severity Scale (SSS); Change in fatigue severity (Fatigue Severity Scale - FSS); Change in fatigue impact (Fatigue Impact Scale - FIS) |
| NCT07597902 | SARS-CoV-2 and Herpesvirus Inhibition for Ending Long COVID Dysfunction (SHIELD) | NOT_YET_RECRUITING | PHASE2 | Icahn School of Medicine at Mount Sinai | EQ-5D-5L Visual Analogue Scale (VAS) | The EuroQol Five-Dimensional Health Questionnaire (EQ-5D-5L); Patient-Reported Outcomes Measurement Information System 29 (PROMIS-29); General Symptom Questionnaire (GSQ-30); Patient Health Questionnaire (PHQ-9); Generalized Anxiety Disorder (GAD-7); COLUMBIA- |
| NCT06585254 | Use of Transcutaneous Vagus Nerve Stimulation in Reducing the Symptoms of Long COVID Patients Who Fulfill Diagnostic Criteria for ME/CFS | RECRUITING | nan | Icahn School of Medicine at Mount Sinai | The Chalder Fatigue Questionnaire (CFQ); Change in Short Form Health Survey (SF-36); Visual Analog Scale (VAS) measuring Fatigue; VAS to measure Widespread Pain; VAS measuring Postexertional malaise (PEM); VAS measuring brain fog; Global Clinical Assessment of | Heart Rate Variability (HRV) |
| NCT07573709 | Functional and Affective Effects of a Brief tDCS Intervention in Fibromyalgia and Chronic Fatigue Syndrome | TERMINATED | nan | Hospital Donostia | Visual Pain Scores (VAS); Fibromyalgia Impact Questionnaire (FIQ) | nan |
| NCT06074848 | Transcranial Direct Current Stimulation as a Strategy for the Management of Disorders Generated by COVID-19: a Multicentric Study. | UNKNOWN | PHASE2 | Universidade Federal de Pernambuco | Fatigue - Modified Fatigue Impact Scale (MFIS); Pain measure - Brief Pain Inventory (BPI); Pain measure - Visual Analog Scale (VAS); Cognitive deficit - Montreal Cognitive Assessment Instrument (MoCA); Cognitive deficit - FAS Test; Cognitive deficit - CFL Test | COVID clinical situation; Level of physical activity; State of strength and effort; Exercise capacity - 6-minute walk test; Immunometabolic evaluation |
| NCT ID | Title | Status | Phase | Sponsor | Primary endpoint | Secondary endpoint |
|---|---|---|---|---|---|---|
| NCT05618587 | Effect of Low-dose Lithium Therapy on Long COVID Symptoms: a Randomized Controlled Trial. | COMPLETED | PHASE2 | State University of New York at Buffalo | Fatigue Severity Scale; Brain Fog Severity Scale | Patient Global Impression of Change (PGIC); Well-Being Scale; Short Form-12 Health Survey (1-week Modification); Desire to Continue Therapy; Generalized Anxiety Disorder-2 Scale; Headache and Body Pain Bother Scale; Insomnia Severity Index; Sense of Smell and |
| NCT04141696 | A Proof-of-Concept Trial on the Effect of Ketamine on Fatigue | COMPLETED | PHASE1; PHASE2 | National Institute of Nursing Research (NINR) | Percentage Change in Self-reported Fatigue Visual Analog Scale (VAS) Scale | Percentage Change in Self-reported Fatigue Visual Analog Scale (VAS) Scale - Day 7; Areas Under the Curve (AUC) for Percentage Changes in Self-reported Fatigue VAS Score - Through Day 7; Mean Physical Activity Count Using Actigraphy; Fatigue Level Measured by |
| NCT05126563 | A Randomized, Double-blinded, Single-center, Phase 2 Efficacy, and Safety Study of Allogeneic HB-adMSCs for the Treatment of Patients With Chronic Post-COVID-19 Syndrome. | COMPLETED | PHASE2 | Hope Biosciences Research Foundation | Changes From Baseline in Visual Analog Scale of Neurological Symptoms. - Extreme Fatigue (ANCOVA Model); Changes From Baseline in Visual Analog Scale of Neurological Symptoms.. - Brain Fog (ANCOVA Model); Changes From Baseline in Visual Analog Scale of Neurolo | Changes From Baseline in Visual Analog Scale of Non-Neurological Symptoms. - Dyspnea at Rest (ANCOVA Model); Changes From Baseline in Visual Analog Scale of Non-Neurological Symptoms. - Dyspnea During Activity (ANCOVA Model); Changes From Baseline in Visual An |
| NCT05472090 | A Phase 2, 14-week Double-Blind, Randomized, Multicenter, Placebo-Controlled Study to Evaluate the Efficacy and Safety of TNX-102 SL Taken Daily at Bedtime in Patients With Multisi | COMPLETED | PHASE2 | Tonix Pharmaceuticals, Inc. | Daily Diary Pain NRS | Daily Diary Sleep Quality NRS; PROMIS Fatigue -Short Form 8a; PROMIS Cognitive Function - Abilities-Short Form 8a |
| NCT06476496 | Pain Relief With Integrative Medicine (PRIMe)?: Feasibility of Acupuncture for Long COVID | COMPLETED | nan | University of Washington | Pain, Enjoyment and General Activity (PEG) | Pain Catastrophizing Scale (PCS) Short Form; PROMIS-29; PROMIS Cognitive Function; UW Pain Related Self-Efficacy Scale (PRSE) |
| NCT06383819 | Multicenter, Randomized, Double-blind, Placebo-controlled Parallel-group Study to Evaluate the Efficacy and Safety of Longidaza® for the Treatment of Patients With Residual Changes | COMPLETED | PHASE3 | NPO Petrovax | Change in Forced vital capacity (FVC) (visit 4) | Slowing the decline in respiratory function; Change in FVC (visit 5); The proportion of patients with an increase in the FVC (%); Dynamics of hemoglobin oxygen saturation (SpO2); The proportion of patients with SpO2 ≥ 93% and < 93%; The proportion of patien |
| NCT05668091 | An Interventional Decentralized Phase 2, Randomized, Double-Blind, 2-Arm Study to Investigate the Efficacy and Safety of Orally Administered Nirmatrelvir/Ritonavir Compared with Pl | COMPLETED | PHASE2 | Harlan M Krumholz | National Institutes of Health (NIH) Patient-Reported Outcomes Measurement Information System (PROMIS)-29 version 2.1 Physical Health Summary Score | Modified General Symptom Questionnaire-30 (Modified GSQ-30); PROMIS® Cognitive Function v.2.0 - Short Form 6a; COVID Core Outcome Measure for Recovery; EuroQol EQ-5D-5L Utility Score-VAS (USA Version); Functional Assessment of Chronic Illness Therapy (FACIT)-I |
| NCT06974058 | Evaluation of a Quercetin/Curcumin-Based Supplement for Mild to Moderate Long COVID-19 Symptoms: A Pragmatic, Interventional Clinical Study. | COMPLETED | nan | Liaquat University of Medical & Health Sciences | Change in Overall Symptom Burden | Change in Functional Status and Quality of Life (SF-36 Scores); Change in the Need for Prescribed Medications or NSAIDs (Non-Steroidal Anti-Inflammatory Drugs); Change in Pain Severity and Pain Interference (Brief Pain Inventory - Short Form); Change in Fatigu |
| NCT05107440 | BREATHE: A Mixed-methods Evaluation of a Virtual Self-management Program for People Living With Long COVID-19 in Alberta | COMPLETED | nan | University of Calgary | Self-efficacy to manage symptoms; Self-efficacy to manage daily activities; Self-efficacy to manage emotions | Self-efficacy to manage symptoms; Self-efficacy to manage daily activities; Self-efficacy to manage emotions; Fatigue severity (FACIT-F); Fatigue severity (FACIT-F); Medical Research Council (MRC) breathlessness scale grade; Medical Research Council (MRC) brea |
| NCT05024474 | Effects of Inspiratory Muscle Training After Covid-19 | COMPLETED | nan | Karolinska Institutet | Change in Maximal Inspiratory Pressure (MIP) | Change in Maximal Expiratory Pressure (MEP); Change in Lung function; Change in walking distance during 6 minute walk test, expressed as percentage of predictive value,; Change in oxygen saturation during 6 minute walk test; Change in oxygen desaturation durin |
| NCT06814379 | Rehabilitation of Fatigue in Patients With Post-COVID-19 Syndrome | COMPLETED | nan | Universidad de Granada | Perceived Fatigue; Multidimensional Fatigue; Fatigue Severity; Fatigue Impact | COVID-19 information; Comorbidities; Dyspnea. The Borg Modified Scale; Dyspnea. Dyspnea-12; Dyspnea. Modified Medical Research Council (mMRC) Dyspnea Scale; Pain intensity; Psychological status; Sleep quality; Health-related Quality of life; Functional status: |
| NCT05697640 | A Parallel-group Treatment, Phase 2a, Double-blind, Placebo-controlled 2-arm Study to Show Improvement of Physical Function in SF-36 (SF-36-PF) in Participants Treated With Vericig | ACTIVE_NOT_RECRUITING | PHASE2 | Charite University, Berlin, Germany | Improvement in Physical Function (PF) as measured by the Short Form 36 Health Survey Questionnaire (SF-36) | Difference in responder rate in Physical Function (PF) as measured by the Short Form 36 Health Survey Questionnaire (SF-36) comparing Vericiguat with placebo; Improvement in other sub-domains of the Short Form 36 Health Survey Questionnaire (SF-36) comparing V |
| NCT06108297 | Effect of Low-dose Lithium Therapy on Long COVID Symptoms: an Open-label, Dose-finding Study. | COMPLETED | PHASE1 | State University of New York at Buffalo | Fatigue Severity Scale (FSS); Brain Fog Severity Scale (BFSS) | Well Being Scale; Short Form-12 Health Survey; FSS scores in those with FSS score ≥28 at baseline; BFSS scores in those with FSS score ≥28 at baseline; Modified Fatigue Impact Scale; Perceived Deficits Questionnaire, 5-Item Version; Beck Depression Inventory-I |
| NCT06960928 | Low Dose Sirolimus in People With Post-Acute Sequelae of COVID-19 (PASC) Long COVID-19 | RECRUITING | PHASE3 | Icahn School of Medicine at Mount Sinai | European Quality of Life-Visual Analogue Scale (EQ-VAS) | The EuroQol Five-Dimensional Health Questionnaire (EQ-5D-5L); Patient-Reported Outcomes Measurement Information System 29 (PROMIS-29); General Symptom Questionnaire (GSQ-30); Patient Health Questionnaire (PHQ-9); Generalized Anxiety Disorder (GAD-7); Neuro-QoL |
| NCT07320833 | Postoperative Analgesic Efficacy of Ultrasound Guided Para-sartorial Compartments (PASC) Block Versus Combined Femoral-Sciatic Nerve Block in Patients Undergoing Total Knee Arthrop | COMPLETED | nan | Ain Shams University | Total Rescue Analgesia Requirement (Nalbuphine) | Postoperative Pain Intensity (Numeric Rating Scale); Motor Block Assessment (Modified Bromage Scale); Block Performance Time; Block Duration; Postoperative Nausea; Postoperative Vomiting; Sedation (Richmond Agitation-Sedation Scale) |
| NCT07238465 | Dysautonomia InVestigation in Individuals With Down SyndromE: DIVE Study | RECRUITING | PHASE3 | University of Colorado, Denver | Seated Baseline Concentration of Plasma Catecholamines; Concentration of Plasma Catecholamines During Cold Pressor Test; Baseline Standing Concentration of Plasma Catecholamines; First Fear Simulation, Concentration of Plasma Catecholamines; Second Fear Simula | Facial Affective Scale Score, Baseline Assessment; Facial Affective Scale Score, Cold Pressor Test, 1.5 Minutes; Facial Affective Scale Score, Cold Pressor Test, Finale; Facial Affective Scale Score, During Pain Response, 1-Minute; Facial Affective Scale Score |
| NCT06597396 | A Phase 2a Randomized, Dose Ranging, Double-Blind, 3-Arm Study to Investigate Orally Administered Abrocitinib Compared With Placebo in Non-Hospitalized Symptomatic Adult Participan | ACTIVE_NOT_RECRUITING | PHASE2 | Beth Israel Deaconess Medical Center | Change from baseline in mean score for FACIT (Functional Assessment of Chronic Illness Therapy) Fatigue Scale | Change from baseline for EQ(EuroQol)-5D-5L values and visual analog scale (VAS) score to Day 84; Change from baseline in PASC Symptom PRO (patient reported outcome) Instrument score to Day 84; Safety-related clinical laboratory test abnormalities and related a |
| NCT05231512 | The Effects of a Music Therapy Respiratory Protocol on Post-Covid Respiratory Symptoms | COMPLETED | nan | Icahn School of Medicine at Mount Sinai | MRC dyspnea score | Self-reported Chronic Respiratory Questionnaire (CRQ-SR); Visual Analog Scale (VAS); Beck Depression Inventory - short form (BDI-SF); General Anxiety Disorder 7-item questionnaire (GAD-7); Hospital Anxiety and Depression Scale (HADS); Coronavirus Anxiety Scale |
| NCT05956405 | Retraining of the Amygdala and Insula for the Treatment of Persistent Covid | COMPLETED | nan | Hospital Miguel Servet | Short Form de 36 items (SF-36); Short Form de 36 items (SF-36); Short Form de 36 items (SF-36); Short Form de 36 items (SF-36); Short Form de 36 items (SF-36); Short Form de 36 items (SF-36) | Sociodemographic data Gender, age, marital status, education, occupation, economical level; Sociodemographic data Gender, age, marital status, education, occupation, economical level; Spanish Chronic Pain Grading Scale; Spanish Chronic Pain Grading Scale; Span |
| NCT04797871 | Resistance Training Intervention on the Clinical Status in Patients With Post Discharge Symptoms After Covid-19: The "EXER-COVID Study" | COMPLETED | nan | Universidad Pública de Navarra | Changes in Cardiorespiratory fitness | Changes in Post-COVID manifestations; Changes in Blood samples analysed for markers related to low grade inflammation; Changes in pulse wave velocity; Changes in cardio-ankle vascular index (CAVI); Changes in Energy expenditure; Changes in bone mineral density |
| NCT05019963 | Enhancing COVID Rehabilitation With Technology (ECORT): An Open-label, Single Site Randomized Controlled Trial Evaluating the Effectiveness of Electronic Case Management for Indivi | ACTIVE_NOT_RECRUITING | nan | University of Ottawa | Change in WHODAS 2.0 score | WHO Post-COVID CRF; PHQ-9; GAD-7; PSQI; PCL-5; EQ-5D-5L; Fatigue Severity Scale; Fatigue Numeric Rating Scale; Pain Numeric Rating Scale; MRC Dyspnoea Scale; WEMWBS; Oral Trail Making Test A and B; Hopkins Verbal Learning Test-Revised (HVLT-R); Digit Span subs |
| NCT07627815 | Phase II, Proof of Concept, Open-Label, Randomized-Controlled Trial Evaluating the Efficacy and Safety of PARAGON Novel Metabolic Regulator Formula (PNMR) in the Management of Long | RECRUITING | PHASE2 | ParagonClinicals Inc. | Change in distance walked on the 6-minute walk test (6MWT) after 6 weeks of treatment. | Change in distance walked on the 6MWT after 3 weeks of treatment.; Proportion of patients achieving an improvement of 30 meters or more on the 6MWT by 3 and 6 weeks on treatment.; Time to achieving an improvement of 30 m or more on the 6MWT by 6 weeks on treat |
| NCT06511063 | Investigating the Feasibility of Repurposing HIV Antivirals in Adults With Long Covid | RECRUITING | PHASE2 | Icahn School of Medicine at Mount Sinai | EuroQol 5-Dimension 5-Level (EQ-5D-5L) Visual Analogue Scale | The EuroQol Five-Dimensional Health Questionnaire (EQ-5D-5L); Patient-Reported Outcomes Measurement Information System 29 (PROMIS-29); General Symptom Questionnaire (GSQ-30); Patient Health Questionnaire (PHQ-9); Generalized Anxiety Disorder (GAD-7); Neuro-QoL |
| NCT06204458 | Evaluation of the Efficacy of Mild Water-filtered Infrared-A Whole-body Hyperthermia to Improve Symptoms and Quality of Life in Patients With Post-COVID Syndrome (HyPoCo) | ACTIVE_NOT_RECRUITING | nan | Universität Duisburg-Essen | Multidimensionl Fatigue Inventory (MFI-20); Multidimensionl Fatigue Inventory (MFI-20) | Multidimensionl Fatigue Inventory (MFI-20); Brief Pain Inventory (BPI) - Intensity of pain (Numeric Rating Scale, NRS); Brief Pain Inventory (BPI) - Intensity of pain (Numeric Rating Scale, NRS); Brief Pain Inventory (BPI) - Intensity of pain (Numeric Rating S |
| NCT04695704 | Double-blind Randomized Clinical Trial, Placebo-controlled to Assess the Efficacy of Montelukast in Mild-moderate Respiratory Symptoms in Patients With Long-COVID-19: E-SPERANZA CO | TERMINATED | PHASE3 | Fundacio d'Investigacio en Atencio Primaria Jordi Gol i Gurina | COP Assessment Test Scale (CAT) | 1min sit-to-stand test; O2 desaturation; Visual Analogical Scale (VAS); All-cause mortality; Number of visits to primary care; Number of visits to the emergency room; Number of hospital admissions.; Medication side effects; Days of sick leave; Factors of infla |
| NCT06586398 | A Pilot Randomized Trial of rTMS for Fatigue and Brain Fog and Neuropsychiatric Symptoms of Long-COVID. | ACTIVE_NOT_RECRUITING | nan | University of California, Los Angeles | Tolerability as measured by Safteesi survey; Safety profile and adverse events | Subjective Cognitive impairment assessed by Multidimensional Inventory of Subjective Cognitive Impairment (MISCI); Fatigue assessed by Fatigue Severity Scale (FSS); Physical and mental health assessed by PROMIS-29; Alzheimer's Disease Assessment Scale (AD |
| NCT05791812 | Application of Direct Current Transcranial stImulation, Remotely superVised in Chronic fATiguE - Heimanwendung Der Transkraniellen Gleichstromstimulation Zur Behandlung Der Chronis | ACTIVE_NOT_RECRUITING | nan | University of Regensburg | Usability for the patients; Usability for the handlers/clinicians; Number of days out of 30 the patients used the device; Number of patients who completed the treatment regularly; Number of responders according the the clinical global impression change score f | Major Depression Inventory; World Health Organisation Quality of life scale (abbreviated Version) (WHOQOL-BREF); Clinical Global Impression change; Pittsburgh sleep quality index; numeric analogue scale pain; d2 test; digital span; Chalder fatigue scale; Bell |
| NCT07567274 | Single-Arm Pilot Study of Compounded DMSO-Based Dual-Route Therapy for Refractory Subjective Tinnitus in PASC and Post-COVID-19 Vaccine Injury | ENROLLING_BY_INVITATION | PHASE2 | Leading Edge Clinic | Proportion of participants with at least 50% reduction in Tinnitus Handicap Inventory (THI) score | Change in Tinnitus Handicap Inventory (THI) score over time; Change in tinnitus loudness on visual analog scale (VAS); Change in tinnitus annoyance/distress on visual analog scale (VAS); Change in sleep interference due to tinnitus on visual analog scale (VAS) |
| NCT07021794 | Effectiveness of Treating Post-COVID-19 Conditions (Long COVID) With the SARS-CoV-2 Specific Monoclonal Antibody, Sipavibart | RECRUITING | PHASE2 | Nancy Klimas | Patient-Reported Outcomes Measurement Information System-29; Review of Treatment Related Adverse Events | Symptom-specific participant-reported outcome measures; Change in Simple Reaction Time (Milliseconds); Self-reported fatigue using MFI; Change in Heart Rate Post-6MWT; Processing Speed; Attention; Systolic Blood Pressure Response During NASA Lean Test; Diastol |
| NCT06655844 | Extended Home-use Trial of a Novel Device to Reduce Chronic Pain | RECRUITING | nan | Icahn School of Medicine at Mount Sinai | Neuropathic Pain Symptom Inventory | Pittsburgh Sleep Quality Index (PSQI); Beck Depression Inventory (BDI); General Anxiety Disorder 7-item questionnaire (GAD-7); Patient's Global Impression of Change (PGIC); Visual analogue scale (VAS)- Pain; Visual analogue scale (VAS)- Sleep |
| NCT06168006 | Effects of a Physical Training Program Using a Mobile App on the Functionality and Cardiovascular Function of Individuals With Post-covid-19 Syndrome: Randomized Clinical Trial | RECRUITING | nan | University of Nove de Julho | Change from baseline in 6 min-walk test distance at 12 weeks; Change from baseline in Glittre test at 12 weeks; Change from baseline in sit and stand test at 12 weeks; Change from baseline in Post-Covid Functional Scale at 12 weeks | Change from baseline in Patient Functional Scale at 12 weeks; Change from baseline in Motor Evoked Potential at 12 weeks; Change from baseline in Modified Medical Research Dyspnea Scale at 12 weeks; Change from baseline in Chalder Physical Fatigue Scale at 12 |
| NCT07242573 | Evaluation of the Effect of Individualized Physical Training and Neuromodulation on Pain, Sleep and Fatigue in Patients With Fibromyalgia: a Randomized Controlled Trial | RECRUITING | nan | National Institute of Geriatrics, Rheumatology and Rehabilitation, Poland | Change in pain intensity (Visual Analogue Scale - VAS 0-10); Change in sleep quality (Pittsburgh Sleep Quality Index - PSQI) | Change in depressive symptoms (Beck Depression Inventory - BDI); Change in Widespread Pain Index (WPI) and Symptom Severity Scale (SSS); Change in fatigue severity (Fatigue Severity Scale - FSS); Change in fatigue impact (Fatigue Impact Scale - FIS) |
| NCT06045338 | Mind Body Intervention for Long COVID | RECRUITING | nan | Beth Israel Deaconess Medical Center | Somatic Symptom Score-8 (SSS-8) | Short Form Brief Pain Inventory (BPI); Fatigue Severity Scale (FSS); The Multidimensional Dyspnea Profile (MDP); Generalized Anxiety Disorder form 7 (GAD-7); Patient Reported Outcomes Measurement Information System survey for function disability (PROMIS); End |
| NCT05525598 | Internet-based Treatment for Patients Suffering From Severe Functional Somatic Disorders: A Randomized Controlled Trial. | RECRUITING | nan | University of Aarhus | Change in SF-36 physical health (SF-36 PPH scales); Clinical Global Improvement Scale (CGI) | The Numeric Rating Scale (NRS); Emotional distress, anxiety, depression subscales of the 92-item Danish version of the Symptom Checklist (SCL-92); The BDS Checklist-25; Whiteley-6 revised; Brief Illness perception questionnaire (b-IPQ); The Behavioural Respons |
| NCT06915324 | Transcranial Direct Current Stimulation (tDCS) of Brain Fog in Patients With Post Treatment Lyme Disease | RECRUITING | nan | Columbia University | Coding test scale score for acute treatment; Coding test scale score for post-treatment follow-up | Composite score of the reaction time measures; Fatigue Severity Scale (FSS) Score; General Symptom Questionnaire (GSQ-30) Score; Generalized Anxiety Disorder-7 (GAD-7) Score; PROMIS Emotional Distress-Depression-Short Form Score; Patient-Reported Outcomes Meas |
| NCT04978571 | A Prospective Study on the Effect of Auricular Percutaneous Electrical Nerve Field Stimulation (PENFS) in Patients With Post Concussion Syndrome (PCS) | RECRUITING | nan | Children's Hospital of Orange County | Immediate Post-Concussion Assessment; Post-Concussion Symptom Scale; Balance Error Scoring Symptom; COGNIGRAM | Abdominal Pain Index; Baxter Animated Retching Faces Nausea Scale; Children's Somatization inventory; Functioning disability inventory; Patient-Reported Outcomes Measurement Information System- Anxiety; Patient-Reported Outcomes Measurement Information Sy |
| NCT07409363 | A Randomised, Single-blind, Sham-controlled, Crossover Pilot Study Assessing the Effect of Non-invasive Vagus Nerve Stimulation (nVNS) on Autonomic Symptoms and Pain Management in | NOT_YET_RECRUITING | nan | University of Leeds | Composite Autonomic Symptom Score-31 (COMPASS-31) total score | Positive overall response to the NASA Lean Test procedure; Maximum increase in heart rate during NASA Lean Test procedure; Brief Pain Inventory - Short Form (BPI-SF): Pain Severity Score; Brief Pain Inventory - Short Form (BPI-SF): Pain Interference Score; Hos |
| NCT06544395 | Efficacy of Non-invasive Neuromodulation Treatments for Post-COVID-19 Sequelae in Patients With Musculoskeletal, Respiratory and Neurological Conditions Due to Impaired Taste and S | NOT_YET_RECRUITING | nan | Clinica Gema Leon | ad hoc patient survey; sex, age, vaccination and number of months with symptoms; Number of participants with musculoskeletal, respiratory and neurological sequelae of taste and smell after COVID-19 | SDOQ-NS questionnaire for social impairments due to loss of smell; SF12 Quality of Life Questionnaire; Brief Smell Identification Test: Assessment of smell.; EuroQoL 5-D scale (validated translation into Spanish) for quality of life.; upper limb functional ind |
| NCT05813899 | Efficacy of Lactobacillus Paracasei PS23 for Patients With Post-COVID-19 Syndrome | TERMINATED | nan | Mackay Memorial Hospital | Clinical Global Impression scales of Severity rated by clinician（CGI） | Wechsler Adult Intelligence Scale 4th version; Color Trails Test（CTT）; Insomnia Severity Index（ISI）; The Quality of Life, Enjoyment, and Satisfaction Questionnaire-16, QLESQ-16; State and Trait Anxiety Index (STAI); Patient Heath Questionnaire-9 (PHQ-9); Visua |
| NCT04924881 | Chinese Medicine for Residue Symptoms of COVID-19 Recovered Patients- A Double-blind, Randomized, Placebo-controlled Study | UNKNOWN | PHASE2 | Chinese University of Hong Kong | The Change of Fatigue Severity Score | Long Term Symptom Assessment; The Change of Fatigue Severity Score (FSS); Improvement of dyspnoea using modified British Medical Research Council (mMRC) dyspnoea scale; The change of EuroQol five-dimension five-level (EQ-5D-5L)5L) questionnaire and it's V |
| NCT05618067 | The Impact of Improved Vagal Function on Periaqueductal Gray Connectivity | NOT_YET_RECRUITING | nan | Virginia Commonwealth University | Change in periaqueductal gray region (PAG) activation - looming task; Change in PAG activation - resting; Change in Heart Rate Variability (HRV) | Change in Fatigue Severity Scale (FSS) score from baseline; Change in Generalized Anxiety Disorder Scale (GAD-2) score from baseline; Differences in Adverse Childhood Experiences (ACE) scores between participants; Change in Pain Catastrophizing Scale (PCS) sco |
| NCT06597682 | A Randomized Controlled Basket Study for Evaluating Immunomodulatory Interventions in Post-Acute Sequelae of SARS-CoV-2 InfEction (RISE) | NOT_YET_RECRUITING | nan | Huashan Hospital | Inflammatory Cardiac Involvement symptom cluster: cardiac magnetic resonance (CMR) indicators; Cough symptom cluster: Leicester Cough Questionnaire (LCQ) scale scores; Fatigue symptom cluster: Fatigue Severity Scale (FSS) scale scores | Inflammatory Cardiac Involvement symptom cluster: other relevant cardiac magnetic resonance (CMR) indicators; Inflammatory Cardiac Involvement symptom cluster: VO2max; Inflammatory Cardiac Involvement symptom cluster: Kansas City Cardiomyopathy Questionnaire ( |
| NCT06004362 | Complementary and Integrative Medicine as an Online Intervention in Patients With Post-covid Syndrome - a Randomized-controlled Mixed-methods Trial. | UNKNOWN | nan | Charite University, Berlin, Germany | Short Form 36 (SF-36), Physical Functioning Scale | Short Form 36 (SF-36); DePaul Post-Exertional Malaise Questionnaire (DSQ-PEM); Post-COVID-Syndrom (PCS) Score; Chalder Fatigue Scale (CFS); Quality of life (EQ-5D-5L); General Self-Efficacy Scale (GSE, German version: ASKU); Visual analog scale (VAS) physical |
| NCT05454683 | Effect of Melatonin Plus Zinc Supplementation on Fatigue, Pain, Sleep Disturbances, Anxiety and Depression, and Autonomic Dysfunction in ME/CFS: a Randomized, Double-blind, Placebo | UNKNOWN | nan | Laboratorios Viñas, S.A. | Self-reported fatigue as assessed by the 40-item Fatigue Impact Scale (FIS-40) over the baseline in the study participants. | The health-related quality of life (HRQoL) as assessed by the Short-Form 36-Item Health Survey (SF-36) over the baseline in the study participants.; Sleep disturbances as assessed by the Pittsburgh Sleep Quality Index (PSQI) questionnaire over the baseline in |
| NCT05725538 | Efficacy of Exercise-based mHealth Intervention for Patients With Post-acute COVID-19 Syndrome Based on Fatigue, Fitness, Post-exertional Dyspnea, Pain, Anxiety, Depression, Cognit | UNKNOWN | nan | University of Cadiz | Longitudinal Change from Baseline up to 24 Weeks Follow-up in Fatigue (Fatigue Severity Scale (FSS)); Longitudinal Change from Baseline up to 24 Weeks Follow-up in Post-exertional dyspnoea (Dyspnoea-12); Longitudinal Change from Baseline up to 24 Weeks Follow- | Longitudinal Change from Baseline up to 24 Weeks Follow-up in Pain intensity (Visual Analog Scale (VAS)); Longitudinal Change from Baseline up to 24 Weeks Follow-up in Upper limb strength (Arm curl test); Longitudinal Change from Baseline up to 24 Weeks Follow |
| NCT05705154 | Connecting Breath and Mind: Development of an Online Holistic Treatment Programme Connecting Psychological Wellbeing and Breathing Techniques in Children and Young People With Long | UNKNOWN | nan | Royal Brompton & Harefield NHS Foundation Trust | Impact score of Strength and Difficulties (SDQ) questionnaire | Revised Childhood Anxiety and Depression Scale (RCADS) questionnaire; EQ-5D-Y; SF-36 Quality of Life; 11 item Chandler Fatigue Questionnaire; Visual Analogue Scale (VAS) Pain scale; FitBit Activity monitoring; Physiotherapy assessment of dysfunctional breathin |
| NCT04599348 | Treatment of CFS and Fibromyalgia With HRG 80 Red Ginseng | UNKNOWN | EARLY_PHASE1 | Practitioners Alliance Network | Composite Visual analog scale of symptoms | VAS of pain and sleep |
| NCT04349605 | Meditation and Yoga for Patients With Persistent Symptoms After Lyme Disease | WITHDRAWN | nan | Research Foundation for Mental Hygiene, Inc. | Fatigue Severity Scale; General Symptom Questionnaire-30; Quality of Life Experience Scale | Pain Visual Analog Scale; Applied Cognition scale; PROMIS-29; SF-12 |
| NCT05289154 | Self- Applied Acupressure and Online Qigong for Patients Suffering From Chronic Fatigue After Corona Virus Infection 19 (COVID-19) - a Randomized Controlled Mixed-methods Study. | UNKNOWN | nan | Charite University, Berlin, Germany | SF-36 Physical Function subscale | EQ5D (EuroQoL 5 domains); SF36 PFS (Short Form 36 physical function subscale); Chalder Fatigue-Scale; VAS physical resilience (visual analogue scale); PHQ9 (Patient Health Questionnaire 9); VAS pain (visual analogue scale); hand grip strength; Spirometry; auto |
| NCT05543590 | Effect of Plasmapheresis on Clinical Improvement and Biological Parameters of Patients With Long-haul COVID: PLEXCOVIL Study, a Randomized Controlled Study. | WITHDRAWN | nan | Hôpital Européen Marseille | Percentage of patients whose fatigue has decreased by 30% on the Chalder scale at M3 compared to its initial state measured at baseline | Observation of the evolution of the fatigue (Chalder scale) felt by the patients during the 6 months of the study in the two groups of patients; Evaluation of the quality of life (SF-36) of patients at month 3 and month 6; Evaluation of the overall impression |
| NCT ID | Title | Status | Phase | Sponsor | Primary endpoint | Secondary endpoint |
|---|---|---|---|---|---|---|
| NCT06393790 | Health Effects of a Strength Training Protocol in Women With Fibromyalgia and Healthy Individuals. | COMPLETED | nan | Catholic University of Murcia | PRE-TEST Time up and go test (TUG test); PRE-TEST 5 Times Sit to stand test (5TSTS); PRE TEST 10 meters walk test; PRE TEST 2 minutes walk; PRE TEST Upper body dinamometry; PRE TEST Lower body dinamometry; PRE TEST Sleep assessment: Karolinska Sleepiness Diary | ACUTE PRE-TEST Time up and go test (TUG test); ACUTE POST-TEST Time up and go test (TUG test); ACUTE PRE-TEST 5 Times Sit to stand test (5TSTS); ACUTE POST-TEST 5 Times Sit to stand test (5TSTS); ACUTE PRE TEST 10 meters walk test; ACUTE POST TEST 10 meters wa |
| NCT05435456 | Effect of Strengthening and Relaxation Exercises on Musculoskeletal Pain, Anxiety, and Sleep Quality on Post-covid Symptoms | COMPLETED | nan | Halic University | McGill Pain Scale short form (SFMPQ); Short-Form 36 (SF-36); Pittsburg Sleep Quality Index; Beck Anxiety Scale | nan |
| NCT05531019 | COVID-19 Sequelae: Treatment and Monitoring of Persistent Symptoms, a Decentralized Approach Focus on the Patient. Use of Dietary Supplement Based on Sea Urchin Eggs With Echinochr | COMPLETED | nan | Fernando Saldarini | Change of symptoms over time-points (baseline, 4 weeks, 8 weeks, 12 weeks) during rutine medical checkup.; Change of lung capacity over four times (baseline, 4 weeks, 8 weeks, 12 weeks) assessed during spirometry.; Change of walking distance during a six minut | Change of Von Willebrand Factor over time-points (baseline, 4 weeks, 12 weeks, 12 weeks) via blood sample.; Change of D Dimer over time-points (baseline, 4 weeks, 12 weeks, 12 weeks) via blood sample.; Change of HS-CRP over time-points (baseline, 4 weeks, 8 we |
| NCT07524179 | The Effect of Therapeutic Touch on Sleep Quality and Fatigue Severity in Advanced Cancer Patients in the Palliative Care Setting: A Randomized Controlled Trial | COMPLETED | nan | Erzurum Technical University | Sleep Quality | Fatigue Severity |
| NCT07455123 | The Effect of a Self-Management Program on Fatigue, Sleep Quality, Psychological Resilience, and Occupational Balance in University Students With High Levels of Fatigue: A Randomiz | COMPLETED | nan | Hacettepe University | Change in Fatigue Severity (Piper Fatigue Scale Total Score); Change in Sleep Quality (Pittsburgh Sleep Quality Index Total Score); Change in Psychological Resilience (Psychological Resilience Scale for Adults Total Score); Change in Occupational Balance (Occu | nan |
| NCT06492577 | Effectiveness of Combined Pulmonary Rehabilitation and Progressive Muscle Relaxation on Long-term COVID-19 Symptoms: a Randomized Controlled Trial | COMPLETED | nan | Spitalul Clinic de Boli Infecțioase și Pneumoftiziologie Dr. Victor Babeș Timișoara | Lung function; Exercise capacity; Anxiety; Depression; Sleep Quality; Psychological Well-being | nan |
| NCT04943276 | A Novel Noninvasive Thermoregulatory Device for Postural Tachycardia | COMPLETED | nan | Stanford University | Change from baseline in Compass-31 survey at study endpoint; Change from baseline in Pittsburg Sleep Quality Index (PSQI) at study endpoint; Change from baseline in Insomnia Severity Scale Index (ISI) at study endpoint; Temperature Quality of life Questionnair | nan |
| NCT06419959 | Improving Cardiovascular Health in Veterans With PTSD by Treating Trauma-Related Nightmares With NightWare | RECRUITING | nan | VA Office of Research and Development | Change in Pittsburgh Sleep Quality Index | Change in physiological sleep - total sleep time; Change in endothelial function; Change in Autonomic function - spontaneous baroreflex sensitivity (BRS); Change in large elastic artery stiffness; Change in large elastic artery stiffness; Change in autonomic f |
| NCT07242573 | Evaluation of the Effect of Individualized Physical Training and Neuromodulation on Pain, Sleep and Fatigue in Patients With Fibromyalgia: a Randomized Controlled Trial | RECRUITING | nan | National Institute of Geriatrics, Rheumatology and Rehabilitation, Poland | Change in pain intensity (Visual Analogue Scale - VAS 0-10); Change in sleep quality (Pittsburgh Sleep Quality Index - PSQI) | Change in depressive symptoms (Beck Depression Inventory - BDI); Change in Widespread Pain Index (WPI) and Symptom Severity Scale (SSS); Change in fatigue severity (Fatigue Severity Scale - FSS); Change in fatigue impact (Fatigue Impact Scale - FIS) |
| NCT06456502 | Effectiveness of Non-invasive Neuromodulation Compared to Placebo on Sleep Quality in Patients With Post-COVID Symptoms: a Randomized Clinical Trial. | RECRUITING | nan | Universidad Rey Juan Carlos | Sleep quality | Heart variability; Cortisol and alpha amylase levels; Psychological variables; The quality of life; Disability; Pain intensity |
| NCT06013085 | Effects of Cognitive-behavioral Therapy for Insomnia in Nurses With Post Covid-19 Condition | NOT_YET_RECRUITING | nan | Tri-Service General Hospital | insomnia severity; sleep quality; sleep efficiency | anxiety; depression; health-related quality of life |
| NCT05951803 | Effectiveness of the Brief Behavioral Intervention for Insomnia in the Teleconsultation Modality (ICBI-TC) on the Symptoms of Anxiety, Depression, Sleep Quality and Quality of Life | UNKNOWN | nan | Hospital General de Mexico | Sleep diary; Patient Health Questionnaire 9 (PHQ-9); Pittsburgh Sleep Quality Index (PSQI); Insomnia Severity Index (ISI); SF-36 Health Survey; Generalized Anxiety Disorder 7 (GAD-7) | Sleep diary; Patient Health Questionnaire 9 (PHQ-9); Pittsburgh Sleep Quality Index (PSQI); Insomnia Severity Index (ISI); SF-36 Health Survey; Generalized Anxiety Disorder 7 (GAD-7); Sleep diary; Patient Health Questionnaire 9 (PHQ-9); Pittsburgh Sleep Qualit |
| NCT06348212 | Effect of Probiotic Strain Lactobacillus Paracasei PS23 on Brain Fog in People With Long COVID | UNKNOWN | nan | Taipei Veterans General Hospital, Taiwan | Long covid related symptoms; Hospital Anxiety and Depression Scale; The Pittsburgh sleep quality index; Fatigue Severity Scale; GI symptoms; Cognitive function-Digit symbol substitution test; Cognitive function-The Montreal Cognitive Assessment(MoCA); Cognitiv | nan |
| NCT ID | Title | Status | Phase | Sponsor | Primary endpoint | Secondary endpoint |
|---|---|---|---|---|---|---|
| NCT05472090 | A Phase 2, 14-week Double-Blind, Randomized, Multicenter, Placebo-Controlled Study to Evaluate the Efficacy and Safety of TNX-102 SL Taken Daily at Bedtime in Patients With Multisi | COMPLETED | PHASE2 | Tonix Pharmaceuticals, Inc. | Daily Diary Pain NRS | Daily Diary Sleep Quality NRS; PROMIS Fatigue -Short Form 8a; PROMIS Cognitive Function - Abilities-Short Form 8a |
| NCT05205460 | Effectiveness of a 12-week Telerehabilitation Training in People With Long COVID: A Randomized Controlled Trial | COMPLETED | nan | Tri-Service General Hospital | Change in Exercise Capacity: Peak Oxygen Uptake (VO2peak) From Baseline to 12 Weeks; Change in Exercise Capacity: Workload (Watt) From Baseline to 12 Weeks; Change in Exercise Capacity: Anaerobic Threshold (AT) From Baseline to 12 Weeks; Change in Lung Functio | Change in Physical Activity Amounts: Taiwan Version of the International Physical Activity Questionnaire From Baseline to 12 Weeks; Change in Confidence Level of Exercise: Questionnaire of Self-Efficacy Items From Baseline to 12 Weeks; Change in Health-Related |
| NCT04938687 | Pilot, Effect of Respiratory-Gated Auricular Vagal Afferent Nerve Stimulation (RAVANS) on Post-Treatment Lyme Disease Syndrome | COMPLETED | nan | Spaulding Rehabilitation Hospital | Horowitz Lyme-Multiple Systemic Infectious Disease Syndrome Questionnaire | Sedentary Behaviors Questionnaire; Fatigue Symptom Inventory; Brief Pain Inventory-Pain 24 Hours; Beck Depression Inventory; Beck Anxiety Inventory; Pittsburgh Sleep Quality Index; Timed Up and Go; Time to Complete 4 Meters at Usual Walking Speed,; NIH Toolbox |
| NCT04997395 | Safety and Tolerability of Full Spectrum Cannabidiol Dominant Medicinal Cannabis in Treating Symptoms Associated With Long COVID: A Feasibility Study | COMPLETED | PHASE2 | Bod Australia | Recruitment rate; Tolerability for the treatment of long COVID; Number of side effects | Long COVID symptoms; Fatigue; Self-reported quality of life; Pain score; Mood (anxiety); Mood (depression); Sleep quality; Resting heart rate (expressed as average beats per minute); Activity levels (number of daily steps, distance walked, stairs climbed, acti |
| NCT07492953 | Using Enhanced External Counterpulsation to Recover Cardiovascular Function for Patient of Chronic Diseases | COMPLETED | nan | National Defense Medical Center, Taiwan | Peak oxygen uptake (Peak VO₂) | The Six-Minute Walk Test (6MWT); Blood Pressure and Heart Rate; PROMIS Physical Health score; PROMIS Mental Health Score; PROMIS Sleep Disturbance Domain; Seattle Angina Questionnaire-7 (SAQ-7) summary score; COPD Assessment Test (CAT) score; Rose Dyspnea Scal |
| NCT06974058 | Evaluation of a Quercetin/Curcumin-Based Supplement for Mild to Moderate Long COVID-19 Symptoms: A Pragmatic, Interventional Clinical Study. | COMPLETED | nan | Liaquat University of Medical & Health Sciences | Change in Overall Symptom Burden | Change in Functional Status and Quality of Life (SF-36 Scores); Change in the Need for Prescribed Medications or NSAIDs (Non-Steroidal Anti-Inflammatory Drugs); Change in Pain Severity and Pain Interference (Brief Pain Inventory - Short Form); Change in Fatigu |
| NCT05119634 | The Effect of Whole Body Vibration Training in Individuals With Post COVID - 19 | COMPLETED | nan | Istanbul University - Cerrahpasa | 6 minutes walking test; 6 minutes pegboard and ring test; International Physical Activity Form (IPAQ); activity monitoring with Actigraf GT3X; peripheral muscle strength measurement; pulmonary function test | Post-COVID-19 Functional Status Scale; Chalder Fatigue Questionnaire; Clinical Frailty Scale; EuroQol- 5 Dimension; Hospital Anxiety and Depression Scale (HADS); Impact of Events Scale (IES-R); Pittsburgh Sleep Quality Index (PSQI); static posturography device |
| NCT05855369 | A Randomized Controlled Trial of Smell Training and Trigeminal Nerve Stimulation in the Treatment of COVID-related Persistent Smell Loss | RECRUITING | PHASE2; PHASE3 | Medical University of South Carolina | Change in Psychophysical Olfactory Function from Baseline to 4 and 12 Weeks; Change in Perceived Intensity of Odorants from Baseline to 4 and 12 Weeks; Change in Perceived Hedonics of Odorants from Baseline to 4 and 12 Weeks; Change in Olfactory-related Qualit | Change in Long COVID Symptoms from Baseline to 4 and 12 Weeks; Change in Sustained Attention from Baseline to 4 and 12 Weeks; Change in Cognitive Function from Baseline to 4 and 12 Weeks; Change in Mood State from Baseline to 4 and 12 Weeks; Change in Sleep Qu |
| NCT05630378 | Evaluation of a Multimodal Integrative Medicine and Naturopathy Program in an Outpatient Setting With Focus on Mind-Body Medicine and Mild Water-filtered Infrared-A Whole-body Hype | COMPLETED | nan | Universität Duisburg-Essen | Fatigue - Change from week 0 to week 11 | Quality of life 1; Hospital Anxiety and Depression; Perceived Stress; perceived Pain; Quality of life 2; Sleep Quality; Resilience |
| NCT06814379 | Rehabilitation of Fatigue in Patients With Post-COVID-19 Syndrome | COMPLETED | nan | Universidad de Granada | Perceived Fatigue; Multidimensional Fatigue; Fatigue Severity; Fatigue Impact | COVID-19 information; Comorbidities; Dyspnea. The Borg Modified Scale; Dyspnea. Dyspnea-12; Dyspnea. Modified Medical Research Council (mMRC) Dyspnea Scale; Pain intensity; Psychological status; Sleep quality; Health-related Quality of life; Functional status: |
| NCT04841759 | The Effects of a Multi-factorial Rehabilitation Program for Healthcare Workers Suffering From Post-COVID-19 Fatigue Syndrome | COMPLETED | nan | Medical University of Vienna | Change of maximum oxygen uptake (VO2max) over time-points (baseline - 4 weeks - 8 weeks) assessed during cardio-pulmonary exercise testing (CPET) | Change of walking distance during a six minutes walk test (6MWT) over time-points (baseline - 4 weeks - 8 weeks); Change of numbers over time-points (baseline - 4 weeks - 8 weeks) how often someone can stand up and sit down on a chair within 30 seconds during |
| NCT06960928 | Low Dose Sirolimus in People With Post-Acute Sequelae of COVID-19 (PASC) Long COVID-19 | RECRUITING | PHASE3 | Icahn School of Medicine at Mount Sinai | European Quality of Life-Visual Analogue Scale (EQ-VAS) | The EuroQol Five-Dimensional Health Questionnaire (EQ-5D-5L); Patient-Reported Outcomes Measurement Information System 29 (PROMIS-29); General Symptom Questionnaire (GSQ-30); Patient Health Questionnaire (PHQ-9); Generalized Anxiety Disorder (GAD-7); Neuro-QoL |
| NCT06723821 | Effectiveness of Noninvasive Neuromodulation in Post-COVID Musculoskeletal Pain in the Short Term: Randomized Clinical Trial | COMPLETED | nan | University of Alcala | Visual Analogue Scale (VAS) | DN4 scale; Pittsburg Sleep Quality Index score; Hospital Anxiety and Depression Scale (HAND); Quality of life SF12 |
| NCT06980636 | Shengmai Liquid for Long COVID Fatigue: a Randomized Placebo-controlled Trial. | RECRUITING | PHASE4 | Beijing University of Chinese Medicine | The degree of improvement in patient fatigue, measured using the Modified Fatigue Impact Scale (MFIS) | Traditional Chinese Medicine Syndrome Score Scale; Improvement in depression, assessed using the 17-item Hamilton Depression Scale; Improvement in anxiety, assessed using the Hamilton Anxiety Scale (HAMA); Improvement in sleep quality, assessed using the Pitts |
| NCT04049331 | Improving Patient-Important Outcomes With Testosterone Replacement in Hypogonadal Men With a Prior History of Cancer | ACTIVE_NOT_RECRUITING | PHASE2 | Seattle Institute for Biomedical and Clinical Research | Fatigue change | Sexual function change; Sexual function change; Body composition change; Changes to mood and well-being; Muscle strength change; Sleep quality change; Sleep quality change; Sleep quality change; Daily physical activity change |
| NCT05231512 | The Effects of a Music Therapy Respiratory Protocol on Post-Covid Respiratory Symptoms | COMPLETED | nan | Icahn School of Medicine at Mount Sinai | MRC dyspnea score | Self-reported Chronic Respiratory Questionnaire (CRQ-SR); Visual Analog Scale (VAS); Beck Depression Inventory - short form (BDI-SF); General Anxiety Disorder 7-item questionnaire (GAD-7); Hospital Anxiety and Depression Scale (HADS); Coronavirus Anxiety Scale |
| NCT05381675 | Short Term Outcomes of Tele-Rehabilitation in Patients With Post-Covid Syndrome | COMPLETED | nan | Harran University | Change from the baseline to the 6th week in mMRC (Modified Medical Research Council) Dyspnoea Scale | Change from the baseline to the 6th week in NPRS; Change from the baseline to the 6th week in the 5 times sit to stand test (5XSST); Change from the baseline to the 6th week in the Hospital Anxiety and Depression Scale; Change from the baseline to the 6th week |
| NCT05172206 | Symptom-based Rehabilitation Compared to Usual Care in Post-COVID - a Randomized Controlled Trial | COMPLETED | nan | Schön Klinik Berchtesgadener Land | Change from baseline Quality of life assessed by Short Form - 12 Questionnaire at week 4 and week 12 | Change from baseline COVID-related symptoms at week 4 and week 12; Change from baseline lung function at week 4 and week 12; Change from baseline blood gas analysis at week 4 and week 12; Change from baseline Cardiac Doppler echocardiography at week 4 and week |
| NCT05035628 | Cardiopulmonary Rehabilitation in Long COVID-19 Patients With Persistent Breathlessness and Fatigue | COMPLETED | nan | Louis Bherer | Change in cardiorespiratory fitness | Change in 6-min walking test performance; Change in Functional mobility; Change in Lower limb muscles strength; Change in Quality-of-life; Change in Anxiety; Change in Anxiety; Change in Sleep quality; Change in functional respiratory capacity; Change in gener |
| NCT05846126 | Digital Rehabilitation With Cognitive Training, Physical Activity and Mindfulness for People With Post-acute COVID-19 Syndrome With Cognitive Impairment. REHABCOVID Project. | COMPLETED | nan | Consorci Sanitari de Terrassa | Differences between groups in scores of global cognition; Differences between groups in scores of selective attention, inhibition, and processing speed; Differences between groups in scores of Visual scanning and processing speed; Differences between groups in | Differences between groups in scores of anxiety; Differences between groups in scores of depression; Differences between groups in scores of Mindfulness levels; Differences between groups in scores of Fatigue; Differences between groups in scores of psychologi |
| NCT06978582 | Effectiveness and Safety of a Tele-rehabilitation Program Based on Mindful and Conscious Movement-based Exercise vs Conventional Low-intensity Exercise on Fatigue and Related Varia | ACTIVE_NOT_RECRUITING | nan | University of Seville | Fatigue | Heart Rate Variability; Perceived pain; Perceived Quality of life; Physical function; Interoceptive awareness; Anxiety and depression levels; Perceived sleep quality; Fear of movement; Somatic vigilance; Treatment feasibility |
| NCT05019963 | Enhancing COVID Rehabilitation With Technology (ECORT): An Open-label, Single Site Randomized Controlled Trial Evaluating the Effectiveness of Electronic Case Management for Indivi | ACTIVE_NOT_RECRUITING | nan | University of Ottawa | Change in WHODAS 2.0 score | WHO Post-COVID CRF; PHQ-9; GAD-7; PSQI; PCL-5; EQ-5D-5L; Fatigue Severity Scale; Fatigue Numeric Rating Scale; Pain Numeric Rating Scale; MRC Dyspnoea Scale; WEMWBS; Oral Trail Making Test A and B; Hopkins Verbal Learning Test-Revised (HVLT-R); Digit Span subs |
| NCT05731570 | Cognitive Impairment in Long Covid: PhEnotyping and RehabilitatiOn (CICERO) | ACTIVE_NOT_RECRUITING | nan | University College, London | Change in Goal-attainment | Change in cognitive function; Change in quality of life (EQ-5D-5L); Change in Life Space Questionnaire; Social Functioning (SF-DEM); Change in Instrumental Activities of Daily Living (IADL) Scale; Generalised Anxiety Disorder Assessment (GAD-7); Change in Pati |
| NCT06739720 | A Randomized, Waitlist-controlled Clinical Study on the Efficacy and Safety of Lingzhi-containing Dietary Supplement CP003 on Chronic Fatigue and Post-COVID Fatigue | NOT_YET_RECRUITING | PHASE2; PHASE3 | The University of Hong Kong | Mean difference in Chalder Fatigue Score | Mean difference in Chalder Fatigue Score; Mean difference in 36-Item Short-Form Health Survey; Mean difference in Fatigue Severity Score; mean difference in (PROMIS) Short Form Fatigue 7A survey; Mean difference in hospital anxiety and depression scale; Mean d |
| NCT06511063 | Investigating the Feasibility of Repurposing HIV Antivirals in Adults With Long Covid | RECRUITING | PHASE2 | Icahn School of Medicine at Mount Sinai | EuroQol 5-Dimension 5-Level (EQ-5D-5L) Visual Analogue Scale | The EuroQol Five-Dimensional Health Questionnaire (EQ-5D-5L); Patient-Reported Outcomes Measurement Information System 29 (PROMIS-29); General Symptom Questionnaire (GSQ-30); Patient Health Questionnaire (PHQ-9); Generalized Anxiety Disorder (GAD-7); Neuro-QoL |
| NCT06952413 | An Exploratory, Placebo-controlled, Double-blind, Phase II Study of the Efficacy and Safety for Rituximab (Genetical Recombination) in Myalgia Encephalomyelitis/Chronic Fatigue Syn | RECRUITING | PHASE2 | National Center of Neurology and Psychiatry, Japan | Improvement rate | Percentage of patients whose MHLW-PS-based ME/CFS severity score improved by 1 or more at each evaluation point (improvement rate) compared to that before the start of treatment with the investigational drug (week 0).; The amount of change in the severity scor |
| NCT06204458 | Evaluation of the Efficacy of Mild Water-filtered Infrared-A Whole-body Hyperthermia to Improve Symptoms and Quality of Life in Patients With Post-COVID Syndrome (HyPoCo) | ACTIVE_NOT_RECRUITING | nan | Universität Duisburg-Essen | Multidimensionl Fatigue Inventory (MFI-20); Multidimensionl Fatigue Inventory (MFI-20) | Multidimensionl Fatigue Inventory (MFI-20); Brief Pain Inventory (BPI) - Intensity of pain (Numeric Rating Scale, NRS); Brief Pain Inventory (BPI) - Intensity of pain (Numeric Rating Scale, NRS); Brief Pain Inventory (BPI) - Intensity of pain (Numeric Rating S |
| NCT06968104 | Stimulation of the Transcutaneous Auricular Vagus Nerve for Improvement of Symptoms in Patients With Post-COVID Syndrome and ME/CFS | ACTIVE_NOT_RECRUITING | nan | University of Luxembourg | Fatigue | Patient Health (Quality of life); Patient Health (Ability); Post-Exertional Malaise (PEM); Autonomic Function; Sleep Quality; Sleepiness; Depression and Anxiety; Patients Activity |
| NCT06231238 | A Randomised Controlled Trial Assessing the Efficacy of Balance Acceptance and Commitment Therapy (ACT) for Long COVID. | ACTIVE_NOT_RECRUITING | nan | King's College London | Physical Component Summary (PCS) of the 36-item Short Form Health Survey (SF-36) at Week 14 | EuroQol 5 Dimension - 5 Levels (EQ-5D-5L); Adult Service Use Schedule; Functional Assessment of Chronic Illness Therapy - Fatigue (FACIT-F); Modified Clinical Global Impressions Scale- Improvement (CGI-I); Pittsburgh Sleep Quality Index (PSQI); Modified Patien |
| NCT05791812 | Application of Direct Current Transcranial stImulation, Remotely superVised in Chronic fATiguE - Heimanwendung Der Transkraniellen Gleichstromstimulation Zur Behandlung Der Chronis | ACTIVE_NOT_RECRUITING | nan | University of Regensburg | Usability for the patients; Usability for the handlers/clinicians; Number of days out of 30 the patients used the device; Number of patients who completed the treatment regularly; Number of responders according the the clinical global impression change score f | Major Depression Inventory; World Health Organisation Quality of life scale (abbreviated Version) (WHOQOL-BREF); Clinical Global Impression change; Pittsburgh sleep quality index; numeric analogue scale pain; d2 test; digital span; Chalder fatigue scale; Bell |
| NCT06124625 | Effects of Rehabilitation Combined With a 12-week Maintenance Program Compared to Rehabilitation Alone in Post-COVID-19 - a Randomized, Controlled Trial. | ACTIVE_NOT_RECRUITING | nan | Schön Klinik Berchtesgadener Land | Change from baseline quality of life assessed by Short-Form 12 questionnaire at week 4 and week 19 | Change from baseline post-COVID-related symptoms at week 4 and week 19; Change from baseline lung function at week 4 and week 19; Change from baseline fatigue symptoms at week 4 and week 19; Change from baseline exercise capacity at week 4 and week 19; Change |
| NCT05719493 | Effectiveness and Health Benefits of a Nutritional, Chronobiological and Physical Exercise Primary Care Intervention in Fibromyalgia and Chronic Fatigue Syndrome: SYNCHRONIZE + Mix | ACTIVE_NOT_RECRUITING | nan | Fundacio d'Investigacio en Atencio Primaria Jordi Gol i Gurina | change in quality of life | change in fatigue indicator; change in sleep quality and insomnia indicator; change in pain indicator; change in adherence to the Mediterranean diet; change in physical exercise practice and sedentary lifestyle; change in circadian biological rhythm; change in |
| NCT06766825 | Phase II Proof-of-concept, Randomized, Double-blind, Placebo-controlled Study to Evaluate the Efficacy and Safety of Plitidepsin in Adults With Post-COVID-19 Condition (PCC) | RECRUITING | PHASE2 | Fundación FLS de Lucha Contra el Sida, las Enfermedades Infecciosas y la Promoción de la Salud y la Ciencia | Change in the overall health in patients from each group using patient reported outcomes measurement information system score (PROMIS-29®). | To compare the safety/tolerability of Plitidepsin Vs placebo in terms of adverse events in patients with PCC.; To compare the incidence of Treatment-Emergent Adverse Events (TEAEs) between groups.; To compare changes in the overall health in patients from each |
| NCT07021794 | Effectiveness of Treating Post-COVID-19 Conditions (Long COVID) With the SARS-CoV-2 Specific Monoclonal Antibody, Sipavibart | RECRUITING | PHASE2 | Nancy Klimas | Patient-Reported Outcomes Measurement Information System-29; Review of Treatment Related Adverse Events | Symptom-specific participant-reported outcome measures; Change in Simple Reaction Time (Milliseconds); Self-reported fatigue using MFI; Change in Heart Rate Post-6MWT; Processing Speed; Attention; Systolic Blood Pressure Response During NASA Lean Test; Diastol |
| NCT06655844 | Extended Home-use Trial of a Novel Device to Reduce Chronic Pain | RECRUITING | nan | Icahn School of Medicine at Mount Sinai | Neuropathic Pain Symptom Inventory | Pittsburgh Sleep Quality Index (PSQI); Beck Depression Inventory (BDI); General Anxiety Disorder 7-item questionnaire (GAD-7); Patient's Global Impression of Change (PGIC); Visual analogue scale (VAS)- Pain; Visual analogue scale (VAS)- Sleep |
| NCT07197138 | Pilot Study on the Effects of Intensified Repetitive Transcranial Magnetic Stimulation on Immunological Blood Parameters in Patients With Depression and Comorbid Post-COVID-19 Cond | RECRUITING | nan | Max-Planck-Institute of Psychiatry | Change in immunophenotypic marker CRP from baseline to post-treatment; Change in immunophenotypic marker TNF from baseline to post-treatment; Change in immunophenotypic marker IL-1ß from baseline to post-treatment; Change in immunophenotypic marker IL-6 from b | Change in Fatigue Severity Scale (FSS, self-rating); Change in Fatigue Scale for Motor and Cognitive Functions (FSMC, self-rating); Change in Post-Exertional Malaise (PEM) Questionnaire (self-rating); Change in Pittsburgh Sleep Quality Index (PSQI, self-rating |
| NCT06829940 | Efficacy of Baduanjin Exercise in COVID-19 Contraction Patients With Idiopathic Chronic Fatigue | RECRUITING | nan | Cairo University | Pulmonary function: By Spirometry Device: | Pulmonary function: By Spirometry Device:; Measuring functional capacity: By Six-minute walk test (6MWT); Modified Borg dyspnea scale (MBDS); Strength of lower limb muscles By a thirty-second sit-to-stand test; Endurance of upper limb muscles: by the maximal r |
| NCT07110714 | Effects of Kneipp Hydrotherapy in Post-COVID-19 Patients: A Randomized Controlled Trial | RECRUITING | nan | Eggensberger OHG | Health-related quality of life by Short Form-12 Health Survey (SF-12) | Fatigue severity by Fatigue Severity Scale; Sleep quality by Pittsburgh Sleep Quality Index; Health status by EuroQol-5 Dimensions-5 Levels; Autonomic function (heart rate variability by photoplethysmography); Resting blood pressure (systolic and diastolic); P |
| NCT06292377 | Better Understanding of Fatigue After STroke | RECRUITING | nan | Brugmann University Hospital | Heart rate variability (HRV); Heart rate variability (HRV); Heart rate variability (HRV); Transthoracic echography (TTE); Transthoracic echography (TTE); Transthoracic echography (TTE); Fatigue Severity Scale (FSS-7); Fatigue Severity Scale (FSS-7); N-terminal | Blood CRP level; Blood neutrophil-to-lymphocyte ratio (NLR); Stroke localization in the brain; Fazekas scale; Global cortical atrophy scale; Informant Questionnaire on Cognitive Decline in the Elderly (IQCODE); Presence for pre-existing fatigue (yes/no); Durat |
| NCT07013903 | Effects of Kneipp Hydrotherapy During Inpatient Post-Covid-19 Rehabilitation: A Randomized Controlled Trial | RECRUITING | nan | Schön Klinik Berchtesgadener Land | Health-related quality of life by Short Form-12 Health Survey (SF-12) | Fatigue severity by Fatigue Severity Scale; Sleep quality by Pittsburgh Sleep Quality Index; Health status by EuroQol-5 Dimensions-5 Levels; Autonomic function (heart rate variability by photoplethysmography); Resting blood pressure (systolic and diastolic); P |
| NCT05890599 | Randomized Multicenter Clinical Trial: Yoga Versus Health Education for the Treatment of Persistent Fatigue in Patients With Post COVID-19 Syndrome | RECRUITING | nan | University Hospital Tuebingen | Fatigue | Fatigue; Health related quality of life SF-12; Health related quality of life SF-12; Health related quality of life EQ-5D-5L; Health related quality of life EQ-5D-5L; Psychological symptoms; Psychological symptoms; Sleep quality; Sleep quality; Stress; Stress; |
| NCT07597902 | SARS-CoV-2 and Herpesvirus Inhibition for Ending Long COVID Dysfunction (SHIELD) | NOT_YET_RECRUITING | PHASE2 | Icahn School of Medicine at Mount Sinai | EQ-5D-5L Visual Analogue Scale (VAS) | The EuroQol Five-Dimensional Health Questionnaire (EQ-5D-5L); Patient-Reported Outcomes Measurement Information System 29 (PROMIS-29); General Symptom Questionnaire (GSQ-30); Patient Health Questionnaire (PHQ-9); Generalized Anxiety Disorder (GAD-7); COLUMBIA- |
| NCT07546539 | The Role of Photobiomodulation in Patients With Chronic Fatigue Syndrome | NOT_YET_RECRUITING | nan | University of Lahore | Fatigue Improvement | Health Related Quality of Life; Functional Capacity; Pain Intensity; Sleep Quality; Psychological Well-Being; Sustained Effects; Safety and Tolerability; Adverse Effects and Safety Profile |
| NCT06795854 | Effect of Aerobic Training Versus Relaxation Techniques on Quality of Life in Patients With Post Covid-19 Irritable Bowel Syndrome | NOT_YET_RECRUITING | nan | Cairo University | IBS Severity Scoring System (IBS-SSS); IBS Quality of Life (IBS-QOL) | The Pittsburgh Sleep Quality Index (PSQI); Perceived Stress Questionnaire (PSQ) |
| NCT07397910 | Clinical Trial to Analyze the Effectiveness of a Natural Compound on Chronic Immune-mediated Inflammatory Status in Subjects Who Have Had SARS-CoV-2 Infection. | NOT_YET_RECRUITING | nan | Universidad Católica San Antonio de Murcia | Immunoinflammatory profile | Clinical signs; Short Form 12 Health Survey; Sleep quality; Sleep efficiency; Fatigue; Dyspnea; Depression; Anxiety; Hospital Anxiety and Depression; Stress level; Cardiorespiratory fitness.; The Rate of Force Development; Maximum Voluntary Isometric Contracti |
| NCT07357688 | The Effect of Acupuncture Therapy on Cognitive Function in Post-COVID-19 Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Study With Multimodal Magnetic Resonance Imaging | NOT_YET_RECRUITING | nan | Xi Wu | Change of Symbol Digit Modality Test score from baseline to the end of 8 weeks | Changes of Digit Span Test scores from baseline to the end of 8 weeks; Changes of Trail Making Test scores from baseline to the end of 8 weeks; Changes of Rey Auditory Verbal Learning Test scores from baseline to the end of 8 weeks; Changes of Stroop Test scor |
| NCT05398692 | Long COVID-19 Rehabilitation & Research Program | TERMINATED | nan | Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center | Change in aerobic capacity (Peak Oxygen Uptake) at 10 weeks after rehabilitation comprehensive (normal intensity) pulmonary rehabilitation program. | Short Form (SF-36); Fatigue Severity Scale (FSS); General Anxiety Disorder Screener (GAD-7); Pittsburg Sleep Quality Score (PSQI); Modified Medical Research Council Dyspnea Scale (mMRC); Modified DePaul Assessment for Post-Exertional Malaise (DSQ-PEM); Patient |
| NCT07621068 | Hyperbaric Oxygen Therapy for Chronic Fatigue Syndrome (CFS) - A Prospective, Randomized, Double-Blind, Sham-Controlled Study | NOT_YET_RECRUITING | nan | Assaf-Harofeh Medical Center | Cardiopulmonary exercise test (CPET) | DePaul Post-Exertional Malaise Questionnaire (DPEMQ); Short Form-36 Health Survey (SF-36); Pittsburgh Sleep Quality Index (PSQI); Brief Symptom Inventory-18 (BSI-18); Montreal Cognitive Assessment (MoCA); NeuroTrax; Brain MRI; Brain EEG; Sleep EEG; Orthostatic |
| NCT05618067 | The Impact of Improved Vagal Function on Periaqueductal Gray Connectivity | NOT_YET_RECRUITING | nan | Virginia Commonwealth University | Change in periaqueductal gray region (PAG) activation - looming task; Change in PAG activation - resting; Change in Heart Rate Variability (HRV) | Change in Fatigue Severity Scale (FSS) score from baseline; Change in Generalized Anxiety Disorder Scale (GAD-2) score from baseline; Differences in Adverse Childhood Experiences (ACE) scores between participants; Change in Pain Catastrophizing Scale (PCS) sco |
| NCT06597682 | A Randomized Controlled Basket Study for Evaluating Immunomodulatory Interventions in Post-Acute Sequelae of SARS-CoV-2 InfEction (RISE) | NOT_YET_RECRUITING | nan | Huashan Hospital | Inflammatory Cardiac Involvement symptom cluster: cardiac magnetic resonance (CMR) indicators; Cough symptom cluster: Leicester Cough Questionnaire (LCQ) scale scores; Fatigue symptom cluster: Fatigue Severity Scale (FSS) scale scores | Inflammatory Cardiac Involvement symptom cluster: other relevant cardiac magnetic resonance (CMR) indicators; Inflammatory Cardiac Involvement symptom cluster: VO2max; Inflammatory Cardiac Involvement symptom cluster: Kansas City Cardiomyopathy Questionnaire ( |
| NCT06004362 | Complementary and Integrative Medicine as an Online Intervention in Patients With Post-covid Syndrome - a Randomized-controlled Mixed-methods Trial. | UNKNOWN | nan | Charite University, Berlin, Germany | Short Form 36 (SF-36), Physical Functioning Scale | Short Form 36 (SF-36); DePaul Post-Exertional Malaise Questionnaire (DSQ-PEM); Post-COVID-Syndrom (PCS) Score; Chalder Fatigue Scale (CFS); Quality of life (EQ-5D-5L); General Self-Efficacy Scale (GSE, German version: ASKU); Visual analog scale (VAS) physical |
| NCT04532827 | The Effectiveness of Web-based Rehabilitation for Enhancing Workability and Daily Functioning for Persistent Physical Symptoms. | UNKNOWN | nan | Finnish Institute of Occupational Health | The 15D questionnaire (health related quality of life) | Demographic questions: age (years); Demographic questions: gender (male, female, prefer not to say); Demographic questions: marital status (Unmarried, married or cohabiting, divorced or separation, widow); Demographic questions: education (basic, secondary, hi |
| NCT05454683 | Effect of Melatonin Plus Zinc Supplementation on Fatigue, Pain, Sleep Disturbances, Anxiety and Depression, and Autonomic Dysfunction in ME/CFS: a Randomized, Double-blind, Placebo | UNKNOWN | nan | Laboratorios Viñas, S.A. | Self-reported fatigue as assessed by the 40-item Fatigue Impact Scale (FIS-40) over the baseline in the study participants. | The health-related quality of life (HRQoL) as assessed by the Short-Form 36-Item Health Survey (SF-36) over the baseline in the study participants.; Sleep disturbances as assessed by the Pittsburgh Sleep Quality Index (PSQI) questionnaire over the baseline in |
| NCT05556733 | Faecal Microbiota Transplantation for Post-acute COVID-19 Syndrome: a Pilot Open-label Study | UNKNOWN | nan | Chinese University of Hong Kong | Change in insomnia severity | Change in sleep quality; Change in anxiety symptoms; Change in daytime sleepiness; Change in fatigue symptoms; Change in sleep diary parameters; Change in gut microbiota composition; Change in gut microbiota diversity and richness; Similarity of gut microbiota |
| NCT05951803 | Effectiveness of the Brief Behavioral Intervention for Insomnia in the Teleconsultation Modality (ICBI-TC) on the Symptoms of Anxiety, Depression, Sleep Quality and Quality of Life | UNKNOWN | nan | Hospital General de Mexico | Sleep diary; Patient Health Questionnaire 9 (PHQ-9); Pittsburgh Sleep Quality Index (PSQI); Insomnia Severity Index (ISI); SF-36 Health Survey; Generalized Anxiety Disorder 7 (GAD-7) | Sleep diary; Patient Health Questionnaire 9 (PHQ-9); Pittsburgh Sleep Quality Index (PSQI); Insomnia Severity Index (ISI); SF-36 Health Survey; Generalized Anxiety Disorder 7 (GAD-7); Sleep diary; Patient Health Questionnaire 9 (PHQ-9); Pittsburgh Sleep Qualit |
| NCT06018649 | The Effectiveness and Safety of Using Lithuania's Natural Resources to Improve Stress-related Mental and Physical Health | UNKNOWN | nan | Klaipėda University | General Symptom Distress Scale (GSDS); PSS-10 (Perceived Stress Scale); Cortisol level in saliva | Anxiety by STAI-5- Spielberger State-Trait Anxiety Inventory; Work and social adjustment by WSAS (work and social adjustment scale); The safety of balneotherapy; Effect on depression- CESD-R (Center for Epidemiological Studies Depression Scale ); Effect on fat |
| NCT05753202 | Neuromodulation Using Transcranial Direct Current Stimulation (tDCS) in Post-COVID Syndrome: Comparison of Two Targets | UNKNOWN | nan | Hospital San Carlos, Madrid | Fatigue Severity Scale (score) | Modified Fatigue Impact Scale (MFIS) (score); FLEI scale (score); Beck Depression Inventory (2nd version) (score); Pittsburgh Sleep Quality Index (score); Brief Pain Inventory (score) |
| NCT ID | Title | Status | Phase | Sponsor | Primary endpoint | Secondary endpoint |
|---|---|---|---|---|---|---|
| NCT04591210 | Evaluation of the Potential Benefit of Renin-angiotensin System Inhibitors (RASi, ACEi/ARB) in High-risk Patients With COVID-19. The COVID-RASi Trial | COMPLETED | PHASE3 | Ottawa Heart Institute Research Corporation | Death; Mechanical ventilation; ICU admission; Major Adverse Cardiac Events (MACE); Hospitalizations; Quality of life of study participants; Quality of life of study participants | Days alive and out of hospital; Days alive and out of hospital; Cardiovascular mortality; All cause hospitalization; Percent of patients require intensive care; Percent of patients requiring ventilation; Percent of patients requiring dialysis |
| NCT06726772 | Post-COVID-19 Symptom Burden: Effects of an Outpatient Group Psychotherapy in Long COVID Patients | COMPLETED | nan | Cantonal Hospital of St. Gallen | Change of Fatigue Score measured with the Questionnaire "FSS" (Fatigue Severity Scale) from baseline to 8 weeks; Change of Insomnia Score measured with the Questionnaire "ISI" (Insomnia Severity Index) from baseline to 8 weeks; Change of Qu | nan |
| NCT04886414 | Implementation and Evaluation of Home-based Care and Hand Hygiene Interventions in Honduras | COMPLETED | nan | Brigham and Women's Hospital | Disposition after referral; Duration of hospitalization; Duration of ICU and/or ventilator requirement; Mortality | nan |
| NCT04751669 | Efficacy of Micronutrient Dietary Supplementation in Reducing Hospital Admissions for COVID-19: A Double-blind, Placebo-controlled, Randomized Clinical Trial | COMPLETED | nan | Fundació Institut Germans Trias i Pujol | Need for hospital admission; Incidence of Long Covid. | Micronutrient basal status (Vitamin B1, Vitamin B6, 25-OH-Vitamin D and Folic Acid; Micronutrient basal status (Vitamin B12); Micronutrient basal status (Iron, Zinc and Copper ); Micronutrient basal status (Vitamin A and Vitamin E); Micronutrient basal status |
| NCT05538650 | Mindfulness-based Social Work and Self-care Study: A Randomised Controlled Trial | COMPLETED | nan | Queen's University, Belfast | Change in Stress measured on the Perceived Stress Scale (PSS); Change in Burnout measured on the Maslach Burnout Inventory (MBI); Change in Anxiety measured on the Hospital Anxiety and Depression Scale (HADS-A); Change in Depression measured on the Hospital An | Change in Mindfulness measured by on the Southampton Mindfulness Questionnaire (SMQ); Change in Self-compassion measured by on the Self-Compassion Scale (SCS); Change in Worry measured on the Penn State Worry Questionnaire (PSWQ); Change in Attention Regulatio |
| NCT03105713 | Development and Implementation of Surgical Safety Checklists for Patients to Use Before Admission, Before Discharge and After Discharge (PASC) - a Stepped Wedge Cluster Randomized | COMPLETED | nan | Haukeland University Hospital | Number of complications associated with the participants surgery; Number of complications within respiratory system; Number of complications within cardio-thoracic system; Number of infections; Number of nervous system complications; Volume of bleeding associa | Number of deaths associated with surgery; Rate of patient scores on Health Literacy Questionaire; Rate of patient scores on EQ5D; Rates of Checklist Implementation Survey scores |
| NCT04801940 | HElping Alleviate the Longer-term Consequences of COVID-19 (HEAL-COVID): a National Platform Trial | UNKNOWN | PHASE3 | Cambridge University Hospitals NHS Foundation Trust | Hospital free survival. | All-cause mortality; Hospital readmission after discharge from index hospital admission; Suspected Serious Adverse Reactions; FACIT-Fatigue; Modified MRC Dyspnoea Scale; COVID-19 core outcome measure for recovery; Patient Health Questionnaire-2 (PHQ-2); Genera |
| NCT06074848 | Transcranial Direct Current Stimulation as a Strategy for the Management of Disorders Generated by COVID-19: a Multicentric Study. | UNKNOWN | PHASE2 | Universidade Federal de Pernambuco | Fatigue - Modified Fatigue Impact Scale (MFIS); Pain measure - Brief Pain Inventory (BPI); Pain measure - Visual Analog Scale (VAS); Cognitive deficit - Montreal Cognitive Assessment Instrument (MoCA); Cognitive deficit - FAS Test; Cognitive deficit - CFL Test | COVID clinical situation; Level of physical activity; State of strength and effort; Exercise capacity - 6-minute walk test; Immunometabolic evaluation |
| NCT04777981 | Efficacy of Cannabidiol in Combination With Red Algae (CBDRA60) to Prevent or Reduce Symptoms of COVID-19 and Post-Acute Sequelae of SARS-CoV-2 Infection PASC | UNKNOWN | nan | Anewsha Therapeutics Inc. | Decreased hospitalization | Resolution of COVID-19 symptoms |
| NCT05000255 | Coping With Covid-19: Loneliness, Self-Efficacy, Social Support and Depression and Anxiety in Patients in Medical Rehabilitation. A Field Study in Geriatrics and Physical Medicine | UNKNOWN | nan | Annette Reichardt, MD | Measurement with the UCLA Loneliness Scale; Measurement with the Hospital Anxiety and Depression Scale (HADS) | Measurements with the General Self-Efficacy Expectancy Scale (GSE); Measurements of Stage-specific Self-Efficacy, German Version, by Lippke, S.; Measurements of Activities against loneliness, German Version, by Lippke, S.; Measurements of Perceived Social Supp |
| NCT06348212 | Effect of Probiotic Strain Lactobacillus Paracasei PS23 on Brain Fog in People With Long COVID | UNKNOWN | nan | Taipei Veterans General Hospital, Taiwan | Long covid related symptoms; Hospital Anxiety and Depression Scale; The Pittsburgh sleep quality index; Fatigue Severity Scale; GI symptoms; Cognitive function-Digit symbol substitution test; Cognitive function-The Montreal Cognitive Assessment(MoCA); Cognitiv | nan |
| NCT ID | Title | Status | Phase | Sponsor | Primary endpoint | Secondary endpoint |
|---|---|---|---|---|---|---|
| NCT04510194 | COVID-OUT: Early Outpatient Treatment for SARS-CoV-2 Infection (COVID-19) | COMPLETED | PHASE3 | University of Minnesota | Clinical Progression to Severe Covid | Clinical Progression to Severe Covid; Progression; Maximum Symptom Severity; Clinical Deterioration: Hospital and Vent >3days; Laboratory Outcome Study; All-cause Study Medicine Discontinuation; Long Covid |
| NCT04920916 | Safety and Efficacy of the Treatment of Hospitalized Patients With COVID 19 Infection With an Inhibitor of IL-4 and IL-13 Signaling: A Phase IIa Trial | COMPLETED | PHASE2 | University of Virginia | Day 28 Ventilator Free Survival; Follow up Study 1 Year Outcome: Pulmonary Function Testing- Oxygen Diffusion and 6 Minute Walk Testing | Proportion of Patients With Eosinophilia; Cumulative Incidence of Grade 3 and 4 Clinical Adverse Events, Serious Adverse Events (SAEs) or Death; SARS-CoV-2 Variants; Change in Plasma Total Immunoglobulin E (IgE) Levels; Change in C-reactive Protein (CRP); Chan |
| NCT05121740 | Extension Study in a Cohort of Adult Patients With SARS-CoV-2 Infection Requiring Hospital Admission and Received Treatment With Plitidepsin in the APLICOV-PC Study | COMPLETED | PHASE1; PHASE2 | PharmaMar | Number and Percentage of Participants With Complications Related to Post COVID-19 Infection | Patients Requiring Oxygen Therapy; Patients With Complications Post COVID-19 Infection (Regardless Relationship, i.e. Related to COVID-19 Infection or Not).; Ratio of Partial Pressure Arterial Oxygen (PaO2) and Fraction of Inspired Oxygen (FiO2); Forced Expira |
| NCT06253806 | Stellate Ganglion Block for the Treatment of COVID-19-Induced Parosmia: Double-Blinded, Placebo-Controlled Randomized Clinical Trial | COMPLETED | PHASE2 | Washington University School of Medicine | Parosmia Olfactory Dysfunction Outcomes Rating | Clinical Global Impression - Severity Scale (CGI-S) Smell Loss; Long-COVID Questionnaire; Olfaction Catastrophizing Scale (OCS); Hospital Anxiety and Depression Scale (HADS); Patient Satisfaction With Treatment; Assessment of the Blind |
| NCT05204550 | A Randomised, Placebo-controlled Trial to Investigate the Efficacy of Intranasal Heparin Treatment to Reduce Transmission of SARS-CoV-2 Infection and COVID 19 Disease Among Househo | COMPLETED | PHASE2; PHASE3 | Murdoch Childrens Research Institute | Number of household contacts (swab negative on day 1) testing positive for SARS-CoV-2 by PCR on either of three routine nasopharyngeal swabs on day 3,5 and 10 after enrolment or on nasopharyngeal swab in response to clinical symptoms in the first 14 days | Number of household contacts (swab negative on day 1 of study) becoming symptomatic of COVID-19 in next 28 days; total number of index cases and household contacts (nasopharyngeal swab positive on day 1) combined, who remain swab positive on day 3; total numbe |
| NCT04988282 | Systemic Corticosteroids in Treatment of Post-COVID-19 Interstitial Lung Disease | COMPLETED | PHASE4 | Turkish Thoracic Society | % of patients with clinical improvement; % of patients with functional improvement; % of patients with radiological improvement | Improvement of diffusion capacity of lung for carbon monoxide (DLCO); Improvement of Forced Vital Capacity (FVC); Improvement of arterial oxygen saturation (SaO2); Improvement of Exercise Capacity; Improvement of mMRC dyspnea score; Respiratory-cause emergency |
| NCT04591210 | Evaluation of the Potential Benefit of Renin-angiotensin System Inhibitors (RASi, ACEi/ARB) in High-risk Patients With COVID-19. The COVID-RASi Trial | COMPLETED | PHASE3 | Ottawa Heart Institute Research Corporation | Death; Mechanical ventilation; ICU admission; Major Adverse Cardiac Events (MACE); Hospitalizations; Quality of life of study participants; Quality of life of study participants | Days alive and out of hospital; Days alive and out of hospital; Cardiovascular mortality; All cause hospitalization; Percent of patients require intensive care; Percent of patients requiring ventilation; Percent of patients requiring dialysis |
| NCT06128967 | An Adaptive, Randomized, doublE-blind, Placebo-controlled, Prospective, Pharmacological interVention Study In Participants With Long COVID-19 Syndrome: REVIVE-TOGETHER Trial | COMPLETED | PHASE3 | Cardresearch | Improvement on Fatigue Severity Score Scale (FSS) | Improvement on Fatigue Severity Score Scale (FSS); Improvement on Fatigue Severity Score Scale (FSS); Reduction on any cause hospitalization; Safety of metformin; Safety of Fluvoxamine; Death of any cause |
| NCT05668091 | An Interventional Decentralized Phase 2, Randomized, Double-Blind, 2-Arm Study to Investigate the Efficacy and Safety of Orally Administered Nirmatrelvir/Ritonavir Compared with Pl | COMPLETED | PHASE2 | Harlan M Krumholz | National Institutes of Health (NIH) Patient-Reported Outcomes Measurement Information System (PROMIS)-29 version 2.1 Physical Health Summary Score | Modified General Symptom Questionnaire-30 (Modified GSQ-30); PROMIS® Cognitive Function v.2.0 - Short Form 6a; COVID Core Outcome Measure for Recovery; EuroQol EQ-5D-5L Utility Score-VAS (USA Version); Functional Assessment of Chronic Illness Therapy (FACIT)-I |
| NCT05852873 | PAxlovid loNg cOvid-19 pRevention triAl With recruitMent In the Community in Norway | ACTIVE_NOT_RECRUITING | PHASE3 | Haukeland University Hospital | Symptoms of long-COVID | Symptoms individually and grouped by organ system; Graded responses for symptoms and symptom constellations; Risk factors for long-COVID; Severity of acute disease; Hospitalisation; Severe adverse events; Absence from work; Societal costs; Symptoms of long-COV |
| NCT06223971 | A Phase l Study to Assess the Safety and Tolerability of PET Imaging With [11 C]CPPC [5-cyano-N-( 4-( 4-[l l CJ me1hylpiperazin-l-yl)-2-(Piperidin-l-yl)Phenyl)Furan-2-carboxamide] | COMPLETED | EARLY_PHASE1 | Johns Hopkins University | To assess the safety and tolerability of one dose level of [11C]CPPC when administered intravenously.; Safety of use of [11C]CPPC in patients with Long-COVID and healthy participants with history of COVID-19 infection as assessed by a change in complete blood | Biodistribution of [11C]CPPC by PET imaging; Cognitive function as assessed by the NIH Toolbox Cognition Battery (NIHTB-CB); Neuro-psychological assessment as assessed by the The Rey-Osterrieth complex figure test (ROCF); Global cognitive function as assessed |
| NCT06974058 | Evaluation of a Quercetin/Curcumin-Based Supplement for Mild to Moderate Long COVID-19 Symptoms: A Pragmatic, Interventional Clinical Study. | COMPLETED | nan | Liaquat University of Medical & Health Sciences | Change in Overall Symptom Burden | Change in Functional Status and Quality of Life (SF-36 Scores); Change in the Need for Prescribed Medications or NSAIDs (Non-Steroidal Anti-Inflammatory Drugs); Change in Pain Severity and Pain Interference (Brief Pain Inventory - Short Form); Change in Fatigu |
| NCT05119634 | The Effect of Whole Body Vibration Training in Individuals With Post COVID - 19 | COMPLETED | nan | Istanbul University - Cerrahpasa | 6 minutes walking test; 6 minutes pegboard and ring test; International Physical Activity Form (IPAQ); activity monitoring with Actigraf GT3X; peripheral muscle strength measurement; pulmonary function test | Post-COVID-19 Functional Status Scale; Chalder Fatigue Questionnaire; Clinical Frailty Scale; EuroQol- 5 Dimension; Hospital Anxiety and Depression Scale (HADS); Impact of Events Scale (IES-R); Pittsburgh Sleep Quality Index (PSQI); static posturography device |
| NCT06694740 | Effect of Interferon Gamma as a Treatment for Post-aggressive Immunosuppression in Intensive Care Units, a Randomized Bayesian Double-blind Controlled Trial Versus Placebo | RECRUITING | PHASE2; PHASE3 | Assistance Publique - Hôpitaux de Paris | number of days alive without mechanical ventilation | Evaluate the efficacy of IFNy in correcting PAIS-defining biological abnormalities (re-ascension of mHLA-DR above 8,000 AB/C) between patients treated with recombinant interferon gamma 1-b versus placebo; Evaluate, depending on the randomization arm, the kinet |
| NCT05630378 | Evaluation of a Multimodal Integrative Medicine and Naturopathy Program in an Outpatient Setting With Focus on Mind-Body Medicine and Mild Water-filtered Infrared-A Whole-body Hype | COMPLETED | nan | Universität Duisburg-Essen | Fatigue - Change from week 0 to week 11 | Quality of life 1; Hospital Anxiety and Depression; Perceived Stress; perceived Pain; Quality of life 2; Sleep Quality; Resilience |
| NCT04751669 | Efficacy of Micronutrient Dietary Supplementation in Reducing Hospital Admissions for COVID-19: A Double-blind, Placebo-controlled, Randomized Clinical Trial | COMPLETED | nan | Fundació Institut Germans Trias i Pujol | Need for hospital admission; Incidence of Long Covid. | Micronutrient basal status (Vitamin B1, Vitamin B6, 25-OH-Vitamin D and Folic Acid; Micronutrient basal status (Vitamin B12); Micronutrient basal status (Iron, Zinc and Copper ); Micronutrient basal status (Vitamin A and Vitamin E); Micronutrient basal status |
| NCT04983394 | Effect of Motion-Controlled Video Games-Based Virtual Reality Exercise On Pain, Fatigue, Mood, Functional Capacity, And Quality of Life in Patients With Post-Covid-19 Condition: A | COMPLETED | nan | Cumhuriyet University | visual Analogue Scale | hospital anxiety and depression scale-Depression; hospital anxiety and depression scale-Anxiety; Fatigue severity scale; Short Form-12; 6 minutes walking test |
| NCT06054438 | Examining the Immunomodulatory and Health Improving Function of a Chinese Medicine Nutritional Supplement Cs4 on Immunity-related Disorders in the Post-COVID Era | COMPLETED | nan | The University of Hong Kong | the change in symptom severity from 0 to 12 weeks measured by the modified COVID-19 Yorkshire Rehabilitation Scale (C19-YRSm) | the change in Insomnia Severity Index (ISI) from 0 to 12 weeks; the change in Brief Fatigue Inventory Form (BFI) from 0 to 12 weeks; the change in St. George's Respiratory Questionnaire (SGRQ) from 0 to 12 weeks; the change in Hospital Anxiety and Depress |
| NCT04527198 | Brainstem Dysfunction in Ventilated and Deeply Sedated COVID-19 Critically Ill Patients: a Prospective Observational Study | COMPLETED | nan | Assistance Publique - Hôpitaux de Paris | Brainstem dysfunction prevalence | Brainstem dysfunction prevalence after sedation weaning; Link between brainstem dysfunction and clinical dysautonomia; Link between brainstem dysfunction and clinical dysautonomia after sedation weaning; Characterization of brainstem dysfunction in COVID-19 pa |
| NCT06723821 | Effectiveness of Noninvasive Neuromodulation in Post-COVID Musculoskeletal Pain in the Short Term: Randomized Clinical Trial | COMPLETED | nan | University of Alcala | Visual Analogue Scale (VAS) | DN4 scale; Pittsburg Sleep Quality Index score; Hospital Anxiety and Depression Scale (HAND); Quality of life SF12 |
| NCT04741841 | Effect of Probiotic Food Supplement "GutMagnific™" in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS), Also Known as Post-viral Fatigue Syndrome, and Comorbid | COMPLETED | nan | ImmuneBiotech Medical Sweden AB | Changes in ME/CFS symptoms | Changes in Irritable Bowel Syndrome (IBS) symptoms; Changes in the gastrointestinal symptoms based on Rome III criteria; Changes in health related quality of life (RAND 36-Item Health Survey); Changes in Hospital Anxiety and Depression Scale (HADS); Changes in |
| NCT05254301 | Faster Functional Performance Recovery After Individualized Nutrition Therapy Combined With a Patient-tailored Physical Rehabilitation Program Versus Standard Physiotherapy in Pati | COMPLETED | nan | Universitair Ziekenhuis Brussel | 1-minute sit-to-stand (1-MSTS) | Multi-dimensional Fatigue Inventor (MFI-20); EuroQol five-dimensional (five-level version) (EQ-5D-5L); Post-COVID-19 Functional Status (PCFS); Hospital Anxiety and Depression Scale (HADS); Work Productivity and Activity Impairment (WPAI) |
| NCT04900961 | Prevention and Early Treatment of the Long-term Physical Effects of Coronarvirus-19 (COVID-19): a Randomised Clinical Trial of Resistance Exercise. | COMPLETED | nan | NHS Greater Glasgow and Clyde | Incremental Shuttle Walk Test | Spirometry; Handgrip Strength; Short Physical Performance Battery; EuroQol-5 dimension (EQ)-5D; Patient Health Questionnaire-4 (PHQ4); Brief Illness Perception Questionnaire (IPQ); Duke Activity Status Index (DASI); International Physical Activity Questionnair |
| NCT05787340 | Investigation From Biopsychosocial Perspective of Patients With Rheumatic Disease With Covid-19 Who Participated in a Biopsychosocial Exercise Program: A Case Series With 6-Month F | COMPLETED | nan | Kahramanmaras Sutcu Imam University | Qualitative research | Bilişsel Egzersiz Terapi Yaklaşımı-Biopsychosocial Questionnaire (BETY-BQ); Health Assessment Questionnaire (HAQ); Hospital Anxiety and Depression Scale (HADS) |
| NCT05684588 | Post-COVID-19 Sequelae: Osteonecrosis of Femoral Head | COMPLETED | nan | FROM- Fondazione per la Ricerca Ospedale di Bergamo- ETS | Number of patients with femoral osteonecrosis | Description of patients clinical features; Description of COVID-19; Description of therapies employed during hospitalization; Definition of the stage of ONFH cases; Number of all ON types that will be detected; To describe and define the stage of all ON cases |
| NCT05231512 | The Effects of a Music Therapy Respiratory Protocol on Post-Covid Respiratory Symptoms | COMPLETED | nan | Icahn School of Medicine at Mount Sinai | MRC dyspnea score | Self-reported Chronic Respiratory Questionnaire (CRQ-SR); Visual Analog Scale (VAS); Beck Depression Inventory - short form (BDI-SF); General Anxiety Disorder 7-item questionnaire (GAD-7); Hospital Anxiety and Depression Scale (HADS); Coronavirus Anxiety Scale |
| NCT05381675 | Short Term Outcomes of Tele-Rehabilitation in Patients With Post-Covid Syndrome | COMPLETED | nan | Harran University | Change from the baseline to the 6th week in mMRC (Modified Medical Research Council) Dyspnoea Scale | Change from the baseline to the 6th week in NPRS; Change from the baseline to the 6th week in the 5 times sit to stand test (5XSST); Change from the baseline to the 6th week in the Hospital Anxiety and Depression Scale; Change from the baseline to the 6th week |
| NCT04301609 | Randomized, Comparative, Double-blind, and Placebo-controlled Clinical Trial to Assess the Improvement of Fatigue, Sleep, Anxiety / Depression, Neurovegetatives Alterations and Qua | COMPLETED | nan | Vitae Health Innovation | Perception of fatigue (FIS-40). | Sleep dysfunction (Pittsburg questionnaire); Hospital anxiety-depression scale (HAD); Quality of life (SF-36) |
| NCT04996212 | Study of the Effectiveness of a Cardiorespiratory Telerehabilitation Program in Persistent COVID-19 Patients. Randomized Clinical Trial. | COMPLETED | nan | University of Valencia | Quality of life (EQ-5D-5L) | Quality of life (EQ-5D-5L) Change from Baseline PostCovid-19 Functional Satatus Scale at five months (PCFSS); Fatigue Assessment Scale (FAS); London Chest Activity of Daily Living Scale (LCADL); Hospital Anxiety and Depression Scale (HADS); Perceived Stress Sc |
| NCT05813873 | The Use of Incentive Spirometry (Triflow) in Patients With Long Covid | ACTIVE_NOT_RECRUITING | nan | European University Cyprus | Barthel Index; Barthel Index; Dyspnoea (Medical Research Council Dyspnoea Scale); Dyspnoea (Medical Research Council Dyspnoea Scale); Peak Flow Meter; Peak Flow Meter | Number of hospitalisation days; Muscle strength (Hand Grip); Muscle strength (Hand Grip); Muscle strength and endurance (30 seconds Sit to stand); Muscle strength and endurance (30 seconds Sit to stand); Balance (Berg Balance); Balance (Berg Balance); Cardiore |
| NCT06148311 | Dexmedetomidine Sublingual Film for the Ambulatory Treatment of Hyperadrenergic Autonomic Crisis in Patients With Familial Dysautonomia | ENROLLING_BY_INVITATION | PHASE2 | NYU Langone Health | Percentage of patients with reduction of Autonomic crisis severity assessment scores (ACSAS) to ≤ 5 points; Percentage of patients with 25% reduction in blood pressure; Percentage of patients with >20% reduction in heart rate; Percentage of patients with &g | Percentage of patients with ≥ 20% reduction in hospitalizations; Percentage of patients with ≥ 20% reduction in hospital stay duration; Percentage of patients with ≥ 30% reduction in ICU stay duration; Change in number of medical complications |
| NCT06739720 | A Randomized, Waitlist-controlled Clinical Study on the Efficacy and Safety of Lingzhi-containing Dietary Supplement CP003 on Chronic Fatigue and Post-COVID Fatigue | NOT_YET_RECRUITING | PHASE2; PHASE3 | The University of Hong Kong | Mean difference in Chalder Fatigue Score | Mean difference in Chalder Fatigue Score; Mean difference in 36-Item Short-Form Health Survey; Mean difference in Fatigue Severity Score; mean difference in (PROMIS) Short Form Fatigue 7A survey; Mean difference in hospital anxiety and depression scale; Mean d |
| NCT04695704 | Double-blind Randomized Clinical Trial, Placebo-controlled to Assess the Efficacy of Montelukast in Mild-moderate Respiratory Symptoms in Patients With Long-COVID-19: E-SPERANZA CO | TERMINATED | PHASE3 | Fundacio d'Investigacio en Atencio Primaria Jordi Gol i Gurina | COP Assessment Test Scale (CAT) | 1min sit-to-stand test; O2 desaturation; Visual Analogical Scale (VAS); All-cause mortality; Number of visits to primary care; Number of visits to the emergency room; Number of hospital admissions.; Medication side effects; Days of sick leave; Factors of infla |
| NCT05167227 | The Long COVID and Fatiguing Illness Recovery Program - A Pragmatic, Quality Improvement, Professional Cluster, Randomized Controlled Trial. | ACTIVE_NOT_RECRUITING | nan | Family Health Centers of San Diego | Patient-Reported Outcomes Measurement Information System (PROMIS)-29 | Patient symptom checklist with associated severity for those present; If symptom is present, has patient experienced this in the past month; If symptom is present, how long has patient experienced this symptom; If symptom is present, did patient have this symp |
| NCT05494424 | Cognitive Rehabilitation in Post-COVID-19 Condition: A Study Protocol for a Randomized Controlled Trial | ACTIVE_NOT_RECRUITING | nan | Lovisenberg Diakonale Hospital | The Metacognition Index from the Behavior Rating Inventory of Executive Function - Adult Version (BRIEF-A) | The Behaviour regulation Index from Behavior Rating Inventory of Executive Function - Adult Version (BRIEF-A); Cambridge Neuropsychological Test Automated Battery (CANTAB), subtests: Spatial Working Memory, Rapid Visual Information Processing, One Touch Stocki |
| NCT06142253 | Water-based Activity to Enhance Recovery in Long COVID | RECRUITING | nan | VA Office of Research and Development | Feasibility of Intervention Measure | Acceptability of Intervention Measure; Change in Fatigue Severity Scale; Change in Mental Fatigue Scale; Change in Digit Span; Change in Digit Symbol Substitution Test; Change in Stroop Color Word Test; Change in Rey Auditory Verbal Learning Test; Change in NI |
| NCT06156176 | Pursuing Reduction in Fatigue After COVID-19 Via Exercise and Rehabilitation (PREFACER): A Randomized Feasibility Trial | RECRUITING | nan | Lawson Research Institute of St. Joseph's | Recruitment; Intervention Fidelity; Retention; Zelen Design Acceptability | Change in 30-Second Sit-to-Stand Test; Change in Borg Scale of Perceived Physical Exertion; Change in The DePaul Symptom Questionnaire; Change in DePaul Symptom Questionnaire - Post-Exertional Malaise (short-form); Change in EQ-5D-5L; Change in Global Rating o |
| NCT04712279 | High-Dose Ivermectin for Mild-to-Moderate COVID-19 - The (HD)IVACOV Trial | UNKNOWN | PHASE2; PHASE3 | Corpometria Institute | World Health Organization (WHO) Clinical Progression Scale [0 to 10; 0 = uninfected; 10 = death] | World Health Organization (WHO) COVID=19 Ordinal Scale for Clinical Improvement [1 to 8; 1 = not hospitalized, no limitation on activities; 8 = death] [Time Frame: Day 7]; Time-to-recovery; Viral load; Positivity rate of rtPCR-SARS-CoV-2 (qualitative analysis) |
| NCT07089719 | Bevacizumab in Post-acute Sequelae of COVID-19 : Efficacy and Safety (Pilot Study) | NOT_YET_RECRUITING | PHASE2 | Assistance Publique - Hôpitaux de Paris | Rate of patients with 10% increase of impaired DLCO | Proportion of patients with recovery of clinical symptoms; Proportion of patients with recovery of psychological, cognitive, and autonomic functions; Proportion of patients with improvement of other parameter than DLCO explored by Pulmonary Function Test; Modi |
| NCT04801940 | HElping Alleviate the Longer-term Consequences of COVID-19 (HEAL-COVID): a National Platform Trial | UNKNOWN | PHASE3 | Cambridge University Hospitals NHS Foundation Trust | Hospital free survival. | All-cause mortality; Hospital readmission after discharge from index hospital admission; Suspected Serious Adverse Reactions; FACIT-Fatigue; Modified MRC Dyspnoea Scale; COVID-19 core outcome measure for recovery; Patient Health Questionnaire-2 (PHQ-2); Genera |
| NCT05706454 | Randomized, Double-Blind, Placebo-Controlled, Parallel-Design, Multi- Centre, Adaptive Phase 2/Phase 3 Study To Evaluate The Efficacy And Safety Of Ramatroban Along With The Standa | UNKNOWN | PHASE2; PHASE3 | KARE Biosciences | Rate of Serious Adverse Events (SAE); Time to Clinical recovery (TTCR) | Composite endpoint of death or need for mechanical ventilation or ECMO; Rate of mechanical ventilation or vasopressor therapy, or ECMO; Ventilator free days; Duration of hospitalization; Duration of ICU stay; Number of subjects who had thrombotic events; Morta |
| NCT05220280 | Long-term Follow-up of a Randomized Multicenter Trial on Impact of Imatinib and Infliximab on Long-COVID in Hospitalized COVID-19 Patients | UNKNOWN | PHASE4 | Clinical Urology and Epidemiology Working Group | Long-COVID symptoms; Long-COVID symptoms; Long-COVID symptoms; Health-related quality of life; Health-related quality of life; Health-related quality of life | Mortality; Incidence of comorbidity; Lung function; Lung function; Lung function; Whole-genome sequencing |
| NCT06973018 | Internetförmedlad Kognitiv Rehabilitering Vid Lindrig Kognitiv störning | ENROLLING_BY_INVITATION | nan | Aniko Bartfai | Mayo Portland Adaptability Inventory - fourth edition (MPAI-4), Participation subscale | MPAI-4 Adaptability subscale; MPAI-4 Abilities subscale; MPAI-4 Total score; Hospital Anxiety and Depression Scale; Life Satisfaction Questionnaire (LiSat-11); Community Integration Questionnaire - Revised (CIQ-R) |
| NCT06055270 | Stellate Ganglion Block With Lidocaine for the Treatment of COVID-19-Induced Parosmia: Double-Blinded, Placebo-Controlled Randomized Clinical Trial | UNKNOWN | PHASE3 | London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's | Parosmia Olfactory Dysfunction Outcomes Rating (DisODOR) | Clinical Global Impression - Severity Scale (CGI-S); Clinical Global Impression - Improvement Scale (CGI-I); University of Pennsylvania Smell Identification Test (UPSIT, Sensonics, New Jersey).; Long-COVID Questionnaire (LCQ); Olfaction Catastrophizing Scale ( |
| NCT06147050 | Pilot Study of an Adaptive, Double-blind, Randomized, Placebo-controlled Study to Evaluate the Effect of Metformin in Reducing Fatigue in Long COVID Adolescent Patients With Chroni | UNKNOWN | PHASE3 | Purpose Life Sciences | Mean Pediatric Quality of Life Multidimensional Fatigue Scale (PedsQL-MFS) score at 90 days post-randomization | Mean PedsQL-MFS score at 30 days post-randomization; Mean PedsQL-MFS score at 60 days post-randomization; Mean Chalder Fatigue Scale (CFS) score at 30 days post-randomization; Mean CFS score at 60 days post-randomization; Mean CFS score at 90 days post-randomi |
| NCT07397910 | Clinical Trial to Analyze the Effectiveness of a Natural Compound on Chronic Immune-mediated Inflammatory Status in Subjects Who Have Had SARS-CoV-2 Infection. | NOT_YET_RECRUITING | nan | Universidad Católica San Antonio de Murcia | Immunoinflammatory profile | Clinical signs; Short Form 12 Health Survey; Sleep quality; Sleep efficiency; Fatigue; Dyspnea; Depression; Anxiety; Hospital Anxiety and Depression; Stress level; Cardiorespiratory fitness.; The Rate of Force Development; Maximum Voluntary Isometric Contracti |
| NCT07600320 | Microtesla Magnetic Therapy (MMT) Treatment of Cognitive Impairment: Open Label Pilot Study | NOT_YET_RECRUITING | nan | Icahn School of Medicine at Mount Sinai | Proportion of participants who complete prescribed device sessions | BrainCheck; Hospital Anxiety and Depression Scale (HADS); PROMIS Sleep Disturbance; Neuro-QoL Cognitive Function (Short Form); PROMIS Fatigue; Patient Global Impression of Change (PGIC); Functional Capacity Assessment (FUNCAP) |
| NCT05684952 | The Efficacy and Safety of a Chinese Herbal Medicine (Shenlingcao Oral Liquid) for Treating Long COVID Associated Fatigue：a Double-blinded, Placebo-controlled, Randomized Clinical | UNKNOWN | PHASE2 | Hong Kong Baptist University | Fatigue: Change of scores in Chalder fatigue scale (0-33 points) | Insomnia: Change of scores in Insomnia Severity Index (ISI); Quality of life: Change of scores in 36-Item Short Form Survey (SF-36); Mood: Change of scores in The Hospital Anxiety and Depression Scale (HADS); Muscle strength: Change of Hand Grip Strength (HGS) |
| NCT07409363 | A Randomised, Single-blind, Sham-controlled, Crossover Pilot Study Assessing the Effect of Non-invasive Vagus Nerve Stimulation (nVNS) on Autonomic Symptoms and Pain Management in | NOT_YET_RECRUITING | nan | University of Leeds | Composite Autonomic Symptom Score-31 (COMPASS-31) total score | Positive overall response to the NASA Lean Test procedure; Maximum increase in heart rate during NASA Lean Test procedure; Brief Pain Inventory - Short Form (BPI-SF): Pain Severity Score; Brief Pain Inventory - Short Form (BPI-SF): Pain Interference Score; Hos |
| NCT06534164 | Telerehabilitation of Balance Clinical and Economic Decision Support System | NOT_YET_RECRUITING | nan | University College, London | Recruitment Rate (acceptability); Incidence of Treatment-Emergent Adverse Events (safety); Feasibility (protocol deviations/problems); Participants experience using the system (usability); Adherence to Intervention; Drop-out rate (acceptability) | Mini Balance Evaluation Systems Test (Mini-BESTest); Functional Gait Assessment (FGA); Incremental cost-effectiveness ratio (ICER); EuroQol five dimensional descriptive system (EQ-5D-5L); Montreal Cognitive Assessment (MoCA); Rapid Assessment of Physical Activ |
| NCT07079787 | Telerehabilitation of Balance Clinical and Economic Decision Support System | NOT_YET_RECRUITING | nan | University College, London | Incidence of Treatment-Emergent Adverse Events (safety); Recruitment Rate (acceptability); Feasibility (protocol deviations/problems); Participants experience using the system (usability); Adherence to Intervention; Drop-out rate (acceptability) | Functional Gait Assessment (FGA); Mini Balance Evaluation Systems Test (Mini-BESTest); Montreal Cognitive Assessment (MoCA); EuroQol five dimensional descriptive system (EQ-5D-5L); Rapid Assessment of Physical Activity (RAPA); Dizziness Handicap Inventory (DHI |
| NCT06386133 | Chronic Fatigue in Multiple Sclerosis: Validating Clinical Performance, Economic, and Organizational Benefits of MSCopilot Boost Compared to Standard Care | NOT_YET_RECRUITING | nan | Ad scientiam | To demonstrate that MSCopilot Boost is superior to standard practice in reducing the impact of fatigue on Patients with Multiple Sclerosis | To evaluate the impact of fatigue in both groups.; To compare the effect of MSCopilot Boost in reducing fatigue impact compared to standard practice (Short term and Medium term); To compare the fatigue impact between the two groups.; To compare the effect of M |
| NCT04482595 | A Phase 2 Study of BIO 300 Oral Suspension in Discharged COVID-19 Patients | UNKNOWN | PHASE2 | Humanetics Corporation | Change in DLCO | Change in 6 Minute Walk Test; Change in FVC; Change in St. George's Respiratory Questionnaire (SGRQ) Scores; Change in Pulmonary Fibrosis on HRCT Scan; Incidence of Re-Hospitalization; All-Cause Mortality; Change in FEV1; Change in FEV1/FVC Ratio; Change |
| NCT05855356 | The Long-CoviD Patients Causal Diagnosis and Rehabilitation Randomized Feasibility Controlled Trial in Patients With Dysautonomia: the LoCoDiRe-Dys Study | UNKNOWN | nan | Evangelismos Hospital | Number of patients with lack of definite Dysautonomia Diagnosis; Compliance, Adverse Events and Protocol Titration to examine feasibility of the trial | 10 minutes NASA Lean Test; Six minute Walk Test; 1 minute sit to stand test; Fatigue Severity Scale; modified Medical Research Council Dyspnea Scale; Nijmegen Questionnaire; Montreal Cognitive Assessment; International Physical Activity Questionnaire; Hospital |
| NCT05454683 | Effect of Melatonin Plus Zinc Supplementation on Fatigue, Pain, Sleep Disturbances, Anxiety and Depression, and Autonomic Dysfunction in ME/CFS: a Randomized, Double-blind, Placebo | UNKNOWN | nan | Laboratorios Viñas, S.A. | Self-reported fatigue as assessed by the 40-item Fatigue Impact Scale (FIS-40) over the baseline in the study participants. | The health-related quality of life (HRQoL) as assessed by the Short-Form 36-Item Health Survey (SF-36) over the baseline in the study participants.; Sleep disturbances as assessed by the Pittsburgh Sleep Quality Index (PSQI) questionnaire over the baseline in |
| NCT05725538 | Efficacy of Exercise-based mHealth Intervention for Patients With Post-acute COVID-19 Syndrome Based on Fatigue, Fitness, Post-exertional Dyspnea, Pain, Anxiety, Depression, Cognit | UNKNOWN | nan | University of Cadiz | Longitudinal Change from Baseline up to 24 Weeks Follow-up in Fatigue (Fatigue Severity Scale (FSS)); Longitudinal Change from Baseline up to 24 Weeks Follow-up in Post-exertional dyspnoea (Dyspnoea-12); Longitudinal Change from Baseline up to 24 Weeks Follow- | Longitudinal Change from Baseline up to 24 Weeks Follow-up in Pain intensity (Visual Analog Scale (VAS)); Longitudinal Change from Baseline up to 24 Weeks Follow-up in Upper limb strength (Arm curl test); Longitudinal Change from Baseline up to 24 Weeks Follow |
| NCT04593225 | Effectiveness of Virtual Multicomponent Treatment for Chronic Fatigue Syndrome: VIRTUAL SFCAMINA STUDY | UNKNOWN | nan | Hospital Universitari Vall d'Hebron Research Institute | Multidimensional Fatigue Inventory (MFI) | Tampa Scale for Kinesiophobia (TSK-11); Hospital Anxiety and Depression Scale (HADS); Physical Function of the 36-Item Short Form Survey (SF-36) |
| NCT05543408 | Long COVID-19 Syndrome in Primary Care: A Novel Protocol of Exercise Intervention "CON-VIDA Clinical Trial" | UNKNOWN | nan | Universidad San Jorge | Change in Lower Limb Strength: 30 s Sit-to-Stand test; Change in Lower Limb Strength: 5 times Sit-to-Stand Test; Change in Handgrip Strength; Chance in upper limbs strength: Arm Curl Biceps; Change in Balance: Flamingo Balance Test; Change in walking speed: Br | Body Composition; Change in Quality of Life-SF-36; Change in The International Physical Activity Questionnaire (IPAQ); Change in Modified Medical Research Council dyspnea scale (mMRC); Change in Modified Fatigue Impact Scale (MFIS); Change in Hospital Anxiety |
| NCT ID | Title | Status | Phase | Sponsor | Primary endpoint | Secondary endpoint |
|---|---|---|---|---|---|---|
| NCT06268288 | Pilot Study--The Effects of Non-invasive Vagal Neurostimulation (nVNS) in Adolescents With Postural Orthostatic Tachycardia Syndrome (POTS) | COMPLETED | nan | Mayo Clinic | The Change in Composite Autonomic Symptom Score (COMPASS-31); The Change in Child Functional Disability Inventory Scores; The Change in Heart Rate (Beats Per Minute) in Head up Tilt Table Tests | Change in the Number of Headaches Experienced by Adolescent Patients With POTS; Change in Exercise Duration (Minutes) in Adolescent Patients With POTS; Change in PHQ-9 Scores in Adolescent Patients With POTS |
| NCT05874037 | Fluvoxamine as a Treatment for Long COVID-19: A Randomized Placebo Controlled Trial | COMPLETED | PHASE2; PHASE3 | Washington University School of Medicine | Total of symptom score via the daily questionnaire | nan |
| NCT06974058 | Evaluation of a Quercetin/Curcumin-Based Supplement for Mild to Moderate Long COVID-19 Symptoms: A Pragmatic, Interventional Clinical Study. | COMPLETED | nan | Liaquat University of Medical & Health Sciences | Change in Overall Symptom Burden | Change in Functional Status and Quality of Life (SF-36 Scores); Change in the Need for Prescribed Medications or NSAIDs (Non-Steroidal Anti-Inflammatory Drugs); Change in Pain Severity and Pain Interference (Brief Pain Inventory - Short Form); Change in Fatigu |
| NCT06726772 | Post-COVID-19 Symptom Burden: Effects of an Outpatient Group Psychotherapy in Long COVID Patients | COMPLETED | nan | Cantonal Hospital of St. Gallen | Change of Fatigue Score measured with the Questionnaire "FSS" (Fatigue Severity Scale) from baseline to 8 weeks; Change of Insomnia Score measured with the Questionnaire "ISI" (Insomnia Severity Index) from baseline to 8 weeks; Change of Qu | nan |
| NCT05798221 | Complementary Self-help Strategies for Patients With Post-COVID-19 Syndrome: A Randomized Controlled Trial | COMPLETED | nan | Universität Duisburg-Essen | Post-COVID-19 symptom burden | Post-COVID-19 symptom burden; Post-COVID-19 functional status (self-reported); Post-COVID-19 functional status (self-reported); Health-related quality of life; Health-related quality of life; Fatigue; Fatigue; Anxiety and depression; Anxiety and depression; In |
| NCT07190105 | Impact of Vagal Approaches on Symptomatology in Long COVID Participants | COMPLETED | nan | Leidos Life Sciences | Patient Health Questionnaire-8 (PHQ-8); Generalized Anxiety Disorder-7 (GAD-7); PTSD Checklist for DSM-5 Short Form (Abbreviated PCL-5); Symptom Burden Questionnaire - Long COVID (SBQ-LC); Body Perception Questionnaire (BPQ); Benefits Scale; Sleep Metrics; Res | nan |
| NCT06054438 | Examining the Immunomodulatory and Health Improving Function of a Chinese Medicine Nutritional Supplement Cs4 on Immunity-related Disorders in the Post-COVID Era | COMPLETED | nan | The University of Hong Kong | the change in symptom severity from 0 to 12 weeks measured by the modified COVID-19 Yorkshire Rehabilitation Scale (C19-YRSm) | the change in Insomnia Severity Index (ISI) from 0 to 12 weeks; the change in Brief Fatigue Inventory Form (BFI) from 0 to 12 weeks; the change in St. George's Respiratory Questionnaire (SGRQ) from 0 to 12 weeks; the change in Hospital Anxiety and Depress |
| NCT06928272 | LC-REVITALIZE - A Long Covid Repurposed Drug Study | RECRUITING | PHASE3 | Douglas D. Fraser | Symptom Burden Questionnaire (SBQ) Subscales | General participant reported overall well-being using the Patient Reported Outcome Measurement Information System (PROMIS)-29 questionnaire; General participant reported overall well-being using the Generalized Anxiety Disorder (GAD)-7 questionnaire; General p |
| NCT05566379 | Effects of a Mindfulness Intervention on Physical and Psychological Well-Being and Quality of Life in Patients With Post Acute Sequelae of SARS-CoV-2 Infection (PASC) Dysautonomia | COMPLETED | nan | University of California, Los Angeles | Change from baseline in the composite autonomic symptom score COMPASS-31 for autonomic symptoms; Change from baseline in Active Stand Test of hemodynamic symptom parameters, exercise tolerance.; Change from baseline of Six Minute Walk in hemodynamic parameters | Change from baseline in mean scores of PSS- Perceived Stress Scale.; Change from baseline in mean scores of GAD7- Generalized Anxiety Disorder; Change from baseline in mean scores of PHQ-8 - Depressive Symptoms; Change from baseline in mean scores of IES-R - e |
| NCT07182578 | Programming Aquatic Therapy for POTS | COMPLETED | nan | California State University, Dominguez Hills | World Health Organization Quality of Life - Brief (WHOQOL-BREF); The DePaul Symptom Questionnaire (Short Form) (DSQ-SF); Composite Autonomic Symptom Score-31; Malmo POTS Scale (MAPS); ADLS, IADLS, and Vestibular Questionnaire; Active Stand Test; Single leg sta | The Stroop Test; Trail Making Test Parts A & B; Enrollment; Attrition Rate; Session attendance rate; Cost analysis; Health utilization changes; Satisfaction Analysis; Exercise self-efficacy; Goal Attainment Scaling; Beighton Score |
| NCT05305105 | Effects of Psilocybin in Post-Treatment Lyme Disease | COMPLETED | PHASE1 | Johns Hopkins University | Change in multi-system symptom burden as assessed by the General Symptom Questionnaire (GSQ-30) score; Change in functional health and well-being as assessed by the Short Health Form (SF-36) score | Change in fatigue as assessed by the Fatigue Severity Scale (FSS) score; Change in pain as assessed by the Short-Form McGill Pain Questionnaire (SF-MPQ) |
| NCT05630040 | Vagus Nerve Simulation for Long-COVID-19 | COMPLETED | nan | Icahn School of Medicine at Mount Sinai | Composite Dysautonomia Symptom Score (COMPASS 31); Composite Dysautonomia Symptom Score (COMPASS 31); Composite Dysautonomia Symptom Score (COMPASS 31); Composite Dysautonomia Symptom Score (COMPASS 31); Composite Dysautonomia Symptom Score (COMPASS 31) | Fatigue Severity Scale (FSS); Fatigue Severity Scale (FSS); Fatigue Severity Scale (FSS); Fatigue Severity Scale (FSS); Fatigue Severity Scale (FSS); Neuro Quality of Life Score; Neuro Quality of Life Score; Neuro Quality of Life Score; Neuro Quality of Life S |
| NCT06211062 | The Use of Directed Probiotics in ME/CFS: Myalgic Encephalomyelitis/Chronic Fatigue Syndrome | RECRUITING | PHASE2 | Nova Southeastern University | The Incidence of Intervention-Related Adverse Events [Safety]; The Measurement of Biomarker Response to an Intervention in the Blood [Efficacy]; level of CRP (C-reactive protein); The pro-inflammatory cytokines level e.g. IL-1, IL-6, and TNF-α; The Symptom Sev | The Impact on the Irritable Bowel Syndrome (IBS) Severity; The IBS-related Quality of Life Measurement |
| NCT04140721 | Autonomic Determinants of Postural Tachycardia Syndrome (Chronic Pilot Study 2) | ACTIVE_NOT_RECRUITING | EARLY_PHASE1 | Vanderbilt University Medical Center | Change in Orthostatic Symptom Burden [delta (delta VOSS)] | Change in Orthostatic Change in Heart Rate [delta (delta HR)] |
| NCT06251518 | Investigating the Effectiveness of Vimida, a Digital Intervention for People Suffering From Post-viral Chronic Fatigue After COVID-19 Infection | ACTIVE_NOT_RECRUITING | nan | Gaia AG | Fatigue symptom severity | Depressive symptoms; Health-related quality of life; Functioning; Somatic symptoms; Anxiety |
| NCT06936319 | Physical Counterpressure Maneuvers in Postural Orthostatic Tachycardia Syndrome (POTS) - a Monocentric, Randomized Controlled Trial | RECRUITING | nan | Medical University Innsbruck | Malmö Postural Orthostatic Tachycardia Syndrome symptom score (MAPS) | Severity of orthostatic intolerance (on a 0 - 10 points scale); Absolute heart rate; Absolute systolic and diastolic blood pressure; Supine-to-standing change in heart rate; Supine-to-standing change in systolic and diastolic blood pressure; Single items of th |
| NCT06045338 | Mind Body Intervention for Long COVID | RECRUITING | nan | Beth Israel Deaconess Medical Center | Somatic Symptom Score-8 (SSS-8) | Short Form Brief Pain Inventory (BPI); Fatigue Severity Scale (FSS); The Multidimensional Dyspnea Profile (MDP); Generalized Anxiety Disorder form 7 (GAD-7); Patient Reported Outcomes Measurement Information System survey for function disability (PROMIS); End |
| NCT07579026 | Effects of Breathing Retraining Exercises on Heartrate, Blood Pressure and Orthostatic Intolerance in Pregnant Females With Postural Orthostatic Tachycardia Syndrome. | RECRUITING | nan | Riphah International University | Vanderbilt Orthostatic symptom score; Non-invasive blood pressure measurement; Pulse oximetry | nan |
| NCT07076862 | Multiparametric Total-Body [18F]F-AraG PET/CT Imaging in Post-Acute Sequelae of SARS-CoV-2 Infection (PASC) | RECRUITING | EARLY_PHASE1 | University of California, Davis | Quantification of [¹⁸F]F-AraG uptake kinetics in PASC and control participants; Correlation between [¹⁸F]F-AraG uptake parameters and blood-based markers of immune dysregulation; Longitudinal change in [¹⁸F]F-AraG uptake and correlation with PASC symptom score | Feasibility of blood flow kinetic modeling using early [¹⁸F]F-AraG dynamic PET data; Correlation between vascular imaging parameters and blood biomarkers of vascular dysfunction |
| NCT05741112 | The Long COVID-19 Wearable Device Study | RECRUITING | nan | Scripps Translational Science Institute | Primary Objective 1:Assess the effect of study-provided devices and enhanced educational materials to manage Long COVID-19 symptom severity, compared to general educational materials alone using data from participants survey responses.; Primary Objective 2: Co | Secondary Objective: Assess the longitudinal impact of sustained use of the study-provided devices and enhanced educational materials on symptom severity. |
| NCT06883513 | Osteopathic Manipulative Therapy(OMT) Effects on Post-Acute Sequalae of COVID-19(PASC) | RECRUITING | nan | University of Louisville | The Symptom Burden Questionnaire™ for Long COVID (SBQ™-LC) | Blood Pressure(BP); Heart Rate (HR) |
| NCT05212129 | Hypermobile Ehlers-Danlos Syndrome: Efficacy of Non-invasive Vagal Nerve Stimulation and Effects on Brain-Gut Physiology | RECRUITING | nan | Medical College of Wisconsin | Change in gastrointestinal symptoms as assessed by the instrument Patient Assessment of upper Gastrointestinal Symptom Severity Index (PAGI-SYM) | Change in gastric motor function as assessed by gastric MRI; Change in Body Perception Questionnaire (BPQ) total score; Change in vagal efficiency measurements |
| NCT07409363 | A Randomised, Single-blind, Sham-controlled, Crossover Pilot Study Assessing the Effect of Non-invasive Vagus Nerve Stimulation (nVNS) on Autonomic Symptoms and Pain Management in | NOT_YET_RECRUITING | nan | University of Leeds | Composite Autonomic Symptom Score-31 (COMPASS-31) total score | Positive overall response to the NASA Lean Test procedure; Maximum increase in heart rate during NASA Lean Test procedure; Brief Pain Inventory - Short Form (BPI-SF): Pain Severity Score; Brief Pain Inventory - Short Form (BPI-SF): Pain Interference Score; Hos |
| NCT06672861 | Development and Validation of the Kansas City Cardiac Dysautonomia Questionnaire (KCDysQ) in Patients With Postural Orthostatic Tachycardia Syndrome, Inappropriate Sinus Tachycardi | NOT_YET_RECRUITING | nan | Kansas City Heart Rhythm Research Foundation | To develop and validate KCDysQ as a quality of life and symptom severity assessment tool | nan |
| NCT05467904 | A Double-Blind Randomized, Placebo-Controlled Trial of a Proprietary Full Hemp Flower Formulation ( Xltran™ and Xltranplus™) to Determine Clinical Improvement in the Syndrome of Lo | WITHDRAWN | nan | LUCINDA BATEMAN, MD | Patient Global Impression of Change (PGIC); Total Symptom Score (TSS) | Insomnia Severity Index; Harvard Flourishing Index (HFI); DANA Brain Vital; Hours of Upright Activity; Daily Steps |
| NCT ID | Title | Status | Phase | Sponsor | Primary endpoint | Secondary endpoint |
|---|---|---|---|---|---|---|
| NCT04510194 | COVID-OUT: Early Outpatient Treatment for SARS-CoV-2 Infection (COVID-19) | COMPLETED | PHASE3 | University of Minnesota | Clinical Progression to Severe Covid | Clinical Progression to Severe Covid; Progression; Maximum Symptom Severity; Clinical Deterioration: Hospital and Vent >3days; Laboratory Outcome Study; All-cause Study Medicine Discontinuation; Long Covid |
| NCT05999435 | A DOUBLE-BLIND, RANDOMIZED, PLACEBO-CONTROLLED, ADAPTIVE PHASE 2/3 STUDY OF THE EFFICACY OF LAU-7b IN THE TREATMENT OF ADULTS WITH LONG COVID AND MODERATE TO SEVERE SYMPTOMS | COMPLETED | PHASE2; PHASE3 | Laurent Pharmaceuticals Inc. | Change From Baseline in Physical Component Summary (PCS) of the Medical Outcomes Study Short-Form-36 (SF-36) at Week 12 | Safety of LAU-7b, Overview; Patient Global Impression of Change (PGI-C); Proportion of Participants With Marked Improvement in PGI-C; Change From Baseline in the Functional Assessment of Chronic Illness Therapy Fatigue (FACIT-F) Scale; Change From Baseline in |
| NCT05877508 | An Exploratory, Randomized, Double-Blind Placebo-Controlled Study to Assess the Safety of an Anti-SARS-CoV-2 Monoclonal Antibody and Response to Treatment in Individuals With Long | ACTIVE_NOT_RECRUITING | PHASE2 | Michael Peluso, MD | Patient-Reported Outcomes Measurement Information System (PROMIS)-29 Physical Health Summary Score | Patient-Reported Outcomes Measurement Information System (PROMIS)-29 Physical Health Summary Score; Patient-Reported Outcomes Measurement Information System (PROMIS)-29 Mental Health Summary Score; Patient-Reported Outcomes Measurement Information System (PROM |
| NCT06524739 | Double-blind, Randomized, Placebo-controlled Phase 3 Study Evaluating Efficacy and Safety of IgPro20 (Subcutaneous Immunoglobulin, HIZENTRA®) in Post-COVID-19 Postural Orthostatic | TERMINATED | PHASE3 | CSL Behring | Proportion of Participants No Longer Meeting Diagnostic Criteria of Post-COVID POTS as Measured by Standardized Standing Test (ie, No Longer Experiencing HR Increase of ≥30 Bpm, in the Absence of 20 mmHg Decrease of SBP [Orthostatic Hypotension]) | Change From Baseline in Orthostatic Intolerance (OI) Score of Composite Autonomic Symptom Score 31 (COMPASS-31); Change From Baseline in COMPASS-31 Total Score; Change From Baseline in Heart Rate Increase Within 10 Minutes of Standing Test; Number of Participa |
| NCT05619653 | Randomised Placebo Controlled Clinical Trial of Efficacy of MYOcardial Protection in Patients With Postacute inFLAMmatory Cardiac involvEment Due to COVID-19 | ACTIVE_NOT_RECRUITING | PHASE3 | Valentina Puentmann | Left ventricular ejection fraction | Scar burden by late gadolinium enhancement (LGE); Cardiopulmonary exercise testing (CPET); Mean T1 and T2 mapping; LV Volume (ml/m2) and LV mass (g/m2); LV strain %; Aortic stiffness (PWV); Aortic wall imaging (LGE); Average Symptom Score (Modified CCS, NYHA, |
| NCT06305806 | RECOVER-AUTONOMIC (Ivabradine): Randomized Trial of the Effect of Ivabradine Versus Placebo on Long COVID Symptoms | COMPLETED | PHASE2 | Kanecia Obie Zimmerman | Change in Orthostatic Hypotension Questionnaire (OHQ)/Orthostatic Intolerance Questionnaire (OIQ) Composite Score | Change in Composite Autonomic Symptoms Score 31 (COMPASS-31); Change in Malmo POTS Symptom Score; Change in heart rate (HR); Change in 6-min Walk Test; Change in PROMIS-29 + 2 Questionnaire; Characterize the safety and tolerability of study intervention for tr |
| NCT05430152 | A Double Blind Randomized Trial of Low-dose Naltrexone for Post-COVID Fatigue Syndrome | COMPLETED | PHASE2 | Luis Nacul | Fatigue Intensity | Pain Severity; Symptom Severity; Activity Levels; Self-reported Quality of Life |
| NCT05857124 | A Pilot Study Evaluating the Efficacy of the Vielight Neuro RX Gamma in the Treatment of Post COVID-19 Cognitive Impairment | COMPLETED | PHASE1 | Vielight Inc. | The change in the combined results of 7 Creyos items: Spatial Planning, Monkey Ladder, Rotations, Feature Match, Paired Associates, Token Search, Polygons. | Creyos scores of the 5 remaining tests (i.e. Grammatical Reasoning, Spatial Span, Digit Span, Odd One Out, Double Trouble); EQ-5D-5L Quality of Life; Fatigue Assessment Scale (FAS); The perceived deficits questionnaire - 20 item version (PDQ-20); Compliance an |
| NCT05710770 | Double-blinded, Randomized, Sham-controlled Trial of Immunoadsorption (IA) in Patients With Chronic Fatigue Syndrome (CFS) Including Patients With Post-acute COVID-19 CFS (PACS-CFS | COMPLETED | nan | Charite University, Berlin, Germany | Improvement in physical and mental fatigue as measured by the Chalder Fatigue Scale | Sustained improvement quantified by the Chalder Fatigue Scale; Verification of safety and tolerability of immunoadsorption in this patient population; Improvement in severity of symptoms of chronic fatigue syndrome (CFS) as measured by the Fluge score; Improve |
| NCT06658340 | Positivity in Post-COVID: Promoting Well-being in Patients with Post-COVID-19 Syndrome - a Feasibility and Acceptability Study | COMPLETED | nan | University of Twente | Feasibility of the intervention exercises; Acceptability of the intervention exercises - willingness to do again; Acceptability of the intervention exercises - satisfaction; Acceptability of the intervention exercises - perceived utility; Acceptability of the | Change in affect; Change in mental well-being; Change in post-COVID symptom severity and functionality; Change in fatigue; Change in anxiety; Change in depression; Change in ability to adapt; Change in perceived illness control; Perceived overall impact |
| NCT05798221 | Complementary Self-help Strategies for Patients With Post-COVID-19 Syndrome: A Randomized Controlled Trial | COMPLETED | nan | Universität Duisburg-Essen | Post-COVID-19 symptom burden | Post-COVID-19 symptom burden; Post-COVID-19 functional status (self-reported); Post-COVID-19 functional status (self-reported); Health-related quality of life; Health-related quality of life; Fatigue; Fatigue; Anxiety and depression; Anxiety and depression; In |
| NCT05697640 | A Parallel-group Treatment, Phase 2a, Double-blind, Placebo-controlled 2-arm Study to Show Improvement of Physical Function in SF-36 (SF-36-PF) in Participants Treated With Vericig | ACTIVE_NOT_RECRUITING | PHASE2 | Charite University, Berlin, Germany | Improvement in Physical Function (PF) as measured by the Short Form 36 Health Survey Questionnaire (SF-36) | Difference in responder rate in Physical Function (PF) as measured by the Short Form 36 Health Survey Questionnaire (SF-36) comparing Vericiguat with placebo; Improvement in other sub-domains of the Short Form 36 Health Survey Questionnaire (SF-36) comparing V |
| NCT04603157 | Remote Self-training Program for Patients With Postural Orthostatic Tachycardia Syndrome (POTS) | COMPLETED | nan | Mayo Clinic | Change Peak Oxygen consumption at 3 months | Change in Composite Autonomic Symptom Score (COMPASS 31) at 3 months; Change in Functional Ability Score at 3 months; Change in 36-Item Short Form Health Survey questionnaire (SF-36) at 3 months; Change in heart rate with 10-min Stand test at 3 months; Change |
| NCT06305793 | RECOVER-AUTONOMIC (IVIG): Randomized Trial of the Effect of IVIG Versus Placebo on Long COVID Symptoms | ACTIVE_NOT_RECRUITING | PHASE2 | Kanecia Obie Zimmerman | Change in Orthostatic Hypotension Questionnaire (OHQ)/Orthostatic Intolerance Questionnaire (OIQ) Composite Score | Change in Composite Autonomic Symptoms Score 31 (COMPASS-31); Change in Malmo POTS Symptom Score; Change in Active Stand Test; Change in blood pressure; Change in heart rate (HR); Change in 6-min Walk Test; Change in Patient-Reported Outcomes Measurement Infor |
| NCT06960928 | Low Dose Sirolimus in People With Post-Acute Sequelae of COVID-19 (PASC) Long COVID-19 | RECRUITING | PHASE3 | Icahn School of Medicine at Mount Sinai | European Quality of Life-Visual Analogue Scale (EQ-VAS) | The EuroQol Five-Dimensional Health Questionnaire (EQ-5D-5L); Patient-Reported Outcomes Measurement Information System 29 (PROMIS-29); General Symptom Questionnaire (GSQ-30); Patient Health Questionnaire (PHQ-9); Generalized Anxiety Disorder (GAD-7); Neuro-QoL |
| NCT05697042 | A Mobile Intervention Merging Yoga and Self-Management Skills (MY-Skills Mobile) for Individuals Experiencing Symptoms of Long COVID-19 | COMPLETED | nan | University of Colorado, Denver | Feasibility- Recruitment; Feasibility- Use; Feasibility- Attrition; Feasibility-Usability | Symptom Burden Scale for Long COVID; PROMIS Fatigue; Brief Pain Inventory; Short Form 36 |
| NCT05422924 | A Pilot and Feasibility Study of a Web-based Platform to Improve Physical Function, Nutrition, and Mindfulness in Patients With Long COVID | COMPLETED | nan | University of Alberta | Feasibility (defined by recruitment, adherence, and retention). | Changes in quality of life parameters; Changes in fat mass; Changes in lean mass; Changes in muscle cross sectional area; Changes in dietary intake; Changes in mindfulness with Mental health questionnaire from the Symptom Burden Questionnaire for Long COVID; C |
| NCT06503913 | Cognitive Muscular Therapy for Patients With Long-COVID (Post COVID-19) and Breathing Pattern Disorder | COMPLETED | nan | University of Salford | Change in Nijmegen Questionnaire | Change in Modified COVID-19 Yorkshire Rehabilitation Scale (C19-YRSm) scale; Change in Dyspnea-12 questionnaire; Change in Self-evaluation of breathing questionnaire; Change in Composite Autonomic Symptom Score; Change in EQ-5D-5L; Change in WHO Disability Ass |
| NCT06631287 | Randomized Double-Blind Placebo-Controlled Trial EValuating Baricitinib on PERSistent NEurologic and Cardiopulmonary Symptoms of Long COVID (REVERSE-LC) | RECRUITING | PHASE3 | Wes Ely | CNS-Vital Signs Global Cognitive Index | Objective neuropsychological function domains of executive function, memory, processing speed, and motor speed including the CNS-Vital Signs subscale tests at 6-months.; Objective neuropsychological function domains of executive function, memory, processing sp |
| NCT06404060 | RECOVER-ENERGIZE: A Platform Protocol for Evaluation of Interventions for Exercise Intolerance in Post-Acute Sequelae of SARS-CoV-2 Infection (PASC) | ACTIVE_NOT_RECRUITING | nan | Duke University | Change in Endurance Shuttle Walk Test (ESWT) | Change in physical function, as measured by the PROMIS SF-Physical Function (PROMIS-PF); Change in physical function, as measured by actigraphy; Change in symptom frequency, as measured by the Modified DePaul Symptom Questionnaire - Post-Exertional Malaise (mD |
| NCT06974084 | A Multi-Center Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy of Maraviroc and Atorvastatin for the Treatment of Subjects With Long COVID/Post-Acute Se | NOT_YET_RECRUITING | PHASE2; PHASE3 | HealthBio, Inc. | Fatigue | Improvement in dysautonomia symptoms as reflected by the Composite Autonomic Symptom Score (COMPASS-31); Improvement in Dyspnea; Improved Cognitive Function, measured by the PROMIS (Patient-Reported Outcomes Measurement Information System) Cognitive Function v |
| NCT06511063 | Investigating the Feasibility of Repurposing HIV Antivirals in Adults With Long Covid | RECRUITING | PHASE2 | Icahn School of Medicine at Mount Sinai | EuroQol 5-Dimension 5-Level (EQ-5D-5L) Visual Analogue Scale | The EuroQol Five-Dimensional Health Questionnaire (EQ-5D-5L); Patient-Reported Outcomes Measurement Information System 29 (PROMIS-29); General Symptom Questionnaire (GSQ-30); Patient Health Questionnaire (PHQ-9); Generalized Anxiety Disorder (GAD-7); Neuro-QoL |
| NCT07316127 | A Placebo-Controlled, Double-Blind, Randomized Trial Phase I-II With Immunoadsorption in Autoimmune Long COVID | RECRUITING | PHASE2 | Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) | Change in fatigue measured by the Fatigue Assessment Scale (FAS) | Change in health related quality of life using the 36-Item Short Form Health Survey (SF-36); Change in cognitive functioning using the Patient-Reported Outcomes Measurement Information System (PROMIS®) Cognitive Function Short Form 8a (PROMIS Cognitive Functio |
| NCT07567274 | Single-Arm Pilot Study of Compounded DMSO-Based Dual-Route Therapy for Refractory Subjective Tinnitus in PASC and Post-COVID-19 Vaccine Injury | ENROLLING_BY_INVITATION | PHASE2 | Leading Edge Clinic | Proportion of participants with at least 50% reduction in Tinnitus Handicap Inventory (THI) score | Change in Tinnitus Handicap Inventory (THI) score over time; Change in tinnitus loudness on visual analog scale (VAS); Change in tinnitus annoyance/distress on visual analog scale (VAS); Change in sleep interference due to tinnitus on visual analog scale (VAS) |
| NCT07021794 | Effectiveness of Treating Post-COVID-19 Conditions (Long COVID) With the SARS-CoV-2 Specific Monoclonal Antibody, Sipavibart | RECRUITING | PHASE2 | Nancy Klimas | Patient-Reported Outcomes Measurement Information System-29; Review of Treatment Related Adverse Events | Symptom-specific participant-reported outcome measures; Change in Simple Reaction Time (Milliseconds); Self-reported fatigue using MFI; Change in Heart Rate Post-6MWT; Processing Speed; Attention; Systolic Blood Pressure Response During NASA Lean Test; Diastol |
| NCT06936319 | Physical Counterpressure Maneuvers in Postural Orthostatic Tachycardia Syndrome (POTS) - a Monocentric, Randomized Controlled Trial | RECRUITING | nan | Medical University Innsbruck | Malmö Postural Orthostatic Tachycardia Syndrome symptom score (MAPS) | Severity of orthostatic intolerance (on a 0 - 10 points scale); Absolute heart rate; Absolute systolic and diastolic blood pressure; Supine-to-standing change in heart rate; Supine-to-standing change in systolic and diastolic blood pressure; Single items of th |
| NCT04271878 | Hypercapnia and Orthostatic Tolerance in Postural Orthostatic Tachycardia Syndrome | RECRUITING | nan | University of Calgary | Heart Rate (HR) variation | Cerebral blood flow velocity (CBFv) variation; VOSS symptom score |
| NCT07585513 | A Randomized Placebo-Controlled Clinical Trial Evaluating Mirabegron's Effectiveness in Alleviating POTS Symptoms | NOT_YET_RECRUITING | PHASE2 | Cedars-Sinai Medical Center | Self-reported frequencies of cardiac-related symptoms as recorded by the number of pushbutton events per day on the monitor. | Malmö POTS Symptom Score; EQ-5D-5L quality of life score; Duke Activity Status Index; Seattle Angina Questionnaire score; OAB-q SF; PROMIS survey; skin sympathetic nerve activity (SKNA) parameters |
| NCT05924646 | CAlgary SAlt for Postural Orthostatic Tachycardia Syndrome Study | RECRUITING | nan | University of Calgary | Upright Heart Rate | Vanderbilt Orthostatic Symptom Score (VOSS); Systolic Blood Pressure; Diastolic Blood Pressure; Stroke volume |
| NCT07242573 | Evaluation of the Effect of Individualized Physical Training and Neuromodulation on Pain, Sleep and Fatigue in Patients With Fibromyalgia: a Randomized Controlled Trial | RECRUITING | nan | National Institute of Geriatrics, Rheumatology and Rehabilitation, Poland | Change in pain intensity (Visual Analogue Scale - VAS 0-10); Change in sleep quality (Pittsburgh Sleep Quality Index - PSQI) | Change in depressive symptoms (Beck Depression Inventory - BDI); Change in Widespread Pain Index (WPI) and Symptom Severity Scale (SSS); Change in fatigue severity (Fatigue Severity Scale - FSS); Change in fatigue impact (Fatigue Impact Scale - FIS) |
| NCT06045338 | Mind Body Intervention for Long COVID | RECRUITING | nan | Beth Israel Deaconess Medical Center | Somatic Symptom Score-8 (SSS-8) | Short Form Brief Pain Inventory (BPI); Fatigue Severity Scale (FSS); The Multidimensional Dyspnea Profile (MDP); Generalized Anxiety Disorder form 7 (GAD-7); Patient Reported Outcomes Measurement Information System survey for function disability (PROMIS); End |
| NCT05858515 | REVERSE-Long COVID: A Multicenter Randomized, Placebo-Controlled Clinical Trial of Immunomodulation (With Baricitinib) for Long COVID Related Cognitive Impairment and ADRD (Alzheim | WITHDRAWN | PHASE3 | Vanderbilt University Medical Center | Enrollment; Diversity in enrollment; Study drug prescribed; Study withdrawals; Adverse event reporting; Study dosing; Study completion | Severe and Serious Adverse Events; Premature study discontinuation; Global Neuropsychological Function; Cardiopulmonary testing; Everyday Cognition; Functional Status; Quality of Life Measures; Post-Exertional Malaise; Shortness of Breath; Symptom Burden; Infl |
| NCT05741112 | The Long COVID-19 Wearable Device Study | RECRUITING | nan | Scripps Translational Science Institute | Primary Objective 1:Assess the effect of study-provided devices and enhanced educational materials to manage Long COVID-19 symptom severity, compared to general educational materials alone using data from participants survey responses.; Primary Objective 2: Co | Secondary Objective: Assess the longitudinal impact of sustained use of the study-provided devices and enhanced educational materials on symptom severity. |
| NCT07285707 | Acupuncture for Long COVID - A Pragmatic Pilot Study | RECRUITING | nan | Southern California University of Health Sciences | Feasibility of Implementing a Combined Acupuncture and Chinese Herbal Medicine Intervention for long COVID | Patient-Reported Acceptability of the Study Procedures and Treatments; Clinician-Reported Acceptability of the Study Protocol; Change in Health-Related Quality of Life Measured by PROMIS-29 v2.1; Change in Symptom Burden Measured by the Symptom Burden Question |
| NCT06863207 | Autonomic Reactivity to Restore a Dysregulated Brain-Gut Axis Via Targeted Therapy | RECRUITING | nan | Medical College of Wisconsin | Patient-Reported Outcomes Measurement Information System (PROMIS) Pediatric Profile-37 | 2. Patient Assessment of upper GastroIntestinal Symptom Severity Index |
| NCT05931497 | A Pilot Study of Whole Body Hyperthermia for Long Covid or Post-Acute Sequelae of COVID-19 (PASC) | RECRUITING | nan | Massachusetts General Hospital | The Patient Reported Outcome Measurement Information System Fatigue-Short Form v1.0 -Fatigue 7a (PROMIS F-SF) | Patient-Reported Outcomes Measurement Information System (PROMIS-29); Patient Health Questionnaire-9 (PHQ); The Perceived Stress Scale (PSS); Patient-Reported Outcomes Measurement Information System Cognitive Abilities; Patient-Reported Outcomes Measurement In |
| NCT06065033 | Exercise as a Therapeutic for Those Diagnosed With Post-acute Sequelae of Covid-19 | WITHDRAWN | nan | University of Virginia | VO2peak; Left ventricular strain; Left ventricular diastolic function | Forced expiratory volume in one second (FEV1); Forced vital capacity (FVC); Post COVID-19 Functional Status scale; Symptom Burden Questionnaire for Long Covid (SBQ-LC); International Physical Activity Questionnaire (IPAQ); NTproBNP; C-reactive protein (CRP); L |
| NCT06159296 | Randomised, Placebo-controlled, Double-blind Cross-over Study to Investigate the Therapeutic Effects of an Inhaled Hydrogen/Oxygen Mixture to Improve Long COVID Symptoms | UNKNOWN | nan | Oxford Brookes University | Breathlessness | Exertional dyspnea; Physical capacity (muscle fatigue); Psychological state and cognitive ability; General long COVID symptom burden |
| NCT05360563 | Effects of a Home-based Exercise Program on the Functional Sequelae of Patients With the Post-COVID-19 Condition: A Randomized Controlled Trial | UNKNOWN | nan | University of Sao Paulo | Change from baseline in functional fitness assessed by distance walked (m) in the six-minute walk test (6MWT) at 16 weeks. | Change from baseline in six-minute walk work (kg.km) assessed by 6MWT at 16 weeks.; Change from baseline in maximal inspiratory muscle strength (cmH2O) assessed by POWERbreathe device at 16 weeks.; Change from baseline in forced vital capacity (FVC; L) assesse |
| NCT ID | Title | Status | Phase | Sponsor | Primary endpoint | Secondary endpoint |
|---|---|---|---|---|---|---|
| NCT04920916 | Safety and Efficacy of the Treatment of Hospitalized Patients With COVID 19 Infection With an Inhibitor of IL-4 and IL-13 Signaling: A Phase IIa Trial | COMPLETED | PHASE2 | University of Virginia | Day 28 Ventilator Free Survival; Follow up Study 1 Year Outcome: Pulmonary Function Testing- Oxygen Diffusion and 6 Minute Walk Testing | Proportion of Patients With Eosinophilia; Cumulative Incidence of Grade 3 and 4 Clinical Adverse Events, Serious Adverse Events (SAEs) or Death; SARS-CoV-2 Variants; Change in Plasma Total Immunoglobulin E (IgE) Levels; Change in C-reactive Protein (CRP); Chan |
| NCT05096884 | Post-Acute Sequelae of Coronavirus-19 (COVID-19) With DysPnEA on ExertIon And Associated TaChycardia TrEatment Study | TERMINATED | EARLY_PHASE1 | Hackensack Meridian Health | Change in 6 Minute Walk Test at the End of Treatment Period; Change in Zva Measurement at the End of Treatment Period | Change in Minnesota Living With Heart Failure Score at the End of Treatment Period |
| NCT04771598 | EVALUATING THE EFFICIENCY OF BREATHING EXERCISES PERFORMED BY POST-COVID TELEMEDICINE: Randomized Controlled Study | COMPLETED | nan | Tokat Gaziosmanpasa University | 6 minute walking test; FEV-1; FVC; FEV1/FVC; MVV | St. George's Respiratory Questionnaire |
| NCT06330376 | Diaphragmatic Breathing Exercises for Post-COVID-19 Diaphragmatic Dysfunction (DD) | COMPLETED | nan | University of Minnesota | 6-minute walk test (6MWT) | PHQ9: Patient health questionnaire 9; GAD7: Generalized anxiety disorder 7-item; PROMIS score: Patient-Reported Outcomes Measurement Information System; QoL scale: Quality of life scale; FACIT fatigue scale 's Fatigue score; Modified Borg dyspnea scale; R |
| NCT06004310 | Effect of Pulmonary Rehabilitation Among Post-COVID-19 Patients in a Tertiary Care Hospital in Bangladesh: A Quasi-Experimental Study | COMPLETED | nan | Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh | Distance: Six-minute walking test (6MWT); Respiratory outcomes: FVC, FEV1, FEV1/FVC ratio, DLCO; Quality of life: Short Form 36 Health Survey Questionnaire (SF-36); Laboratory investigations: CRP and D-dimer | nan |
| NCT05531019 | COVID-19 Sequelae: Treatment and Monitoring of Persistent Symptoms, a Decentralized Approach Focus on the Patient. Use of Dietary Supplement Based on Sea Urchin Eggs With Echinochr | COMPLETED | nan | Fernando Saldarini | Change of symptoms over time-points (baseline, 4 weeks, 8 weeks, 12 weeks) during rutine medical checkup.; Change of lung capacity over four times (baseline, 4 weeks, 8 weeks, 12 weeks) assessed during spirometry.; Change of walking distance during a six minut | Change of Von Willebrand Factor over time-points (baseline, 4 weeks, 12 weeks, 12 weeks) via blood sample.; Change of D Dimer over time-points (baseline, 4 weeks, 12 weeks, 12 weeks) via blood sample.; Change of HS-CRP over time-points (baseline, 4 weeks, 8 we |
| NCT05967052 | Investigation of Pregabalin Therapy and Complex Rehabilitation in Treating Chronic Fatigue Associated With Post-COVID Syndrome | RECRUITING | PHASE2 | National Institute of Geriatrics, Rheumatology and Rehabilitation, Poland | Change in fatigue intensity expressed as a difference in Multidimensional Fatigue Inventory-20 (MFI-20) score; Walking distance as a difference in score from the 6 Minute Walking Test | Change in the level of satisfaction with life expressed in the form of the result of the Satisfaction with Life Scale (Juczyński); Change in the result obtained in the "Beck Depression Inventory (BDIII)" study; Change in the result obtained in the an |
| NCT07254377 | START: Design and Validation of Innovative Strategies Based on Dual-Task Approach for Neuro- Rehabilitation Technologically-supported in People With Chronic Neuro-inflammatory Dise | ACTIVE_NOT_RECRUITING | nan | I.R.C.C.S. Fondazione Santa Lucia | 6-Minute Walking Test | Montreal Cognitive Assessment |
| NCT07627815 | Phase II, Proof of Concept, Open-Label, Randomized-Controlled Trial Evaluating the Efficacy and Safety of PARAGON Novel Metabolic Regulator Formula (PNMR) in the Management of Long | RECRUITING | PHASE2 | ParagonClinicals Inc. | Change in distance walked on the 6-minute walk test (6MWT) after 6 weeks of treatment. | Change in distance walked on the 6MWT after 3 weeks of treatment.; Proportion of patients achieving an improvement of 30 meters or more on the 6MWT by 3 and 6 weeks on treatment.; Time to achieving an improvement of 30 m or more on the 6MWT by 6 weeks on treat |
| NCT04652518 | A Phase 2 Randomized, Double-blind, Placebo-controlled Trial and Open Label Extension to Evaluate the Safety and Efficacy of Deupirfenidone (LYT-100) in Post-acute COVID-19 Respira | TERMINATED | PHASE2 | PureTech | Change in distance walked on the six-minute walk test (6MWT) | Change in Dyspnoea-12 score; Change in Saint George Respiratory Questionnaire-I (SGRQ-I) score; Change in Modified Borg Dyspnoea Scale (mBDS) score; Quality of Life assessment as collected using the SF-36 |
| NCT05116761 | Bone Marrow Mesenchymal Stem Cell Derived Extracellular Vesicles Infusion Treatment for Post-Acute and Chronic Post-COVID-19 Syndrome: A Phase I/II Clinical Trial | WITHDRAWN | PHASE1; PHASE2 | Direct Biologics, LLC | Increased distance on Six Minute Walk Test (6MWT); Incidence of Serious Adverse Events (SAEs) | EuroQol-5D (EQ-5D); Medical Research Council (MRC) Dyspnea Scale |
| NCT04909892 | A Phase 2a Study of Intravenous Allogeneic Adipose-Derived Mesenchymal Stem Cells to Treat Post COVID-19 "Long Haul" Pulmonary Compromise | WITHDRAWN | PHASE2 | Sorrento Therapeutics, Inc. | Change in 6-Minute Walk Distance (6MWD) at Day 60 | Change in 6MWD at Day 30; Change in Pulmonary Function Tests (PFTs); Change in oxygenation; Change in biomarker levels |
| NCT04992247 | A Phase 2A Randomized, Placebo-Controlled Study of Intravenous Allogeneic Adipose-Derived Mesenchymal Stem Cells to Treat Post COVID-19 "Long Haul" Pulmonary Compromise | WITHDRAWN | PHASE2 | Sorrento Therapeutics, Inc. | Change in 6-Minute Walk Distance (6MWD) at Day 60 | Change in 6MWD at Day 30; Relief of symptoms on Day 30 and Day 60; Change in Pulmonary Function; Change in oxygenation; Change in biomarker levels |
| NCT04947488 | Evaluation of the Effects of Treatment With Bioarginin C on Physical Exhaustion , Systemic Inflammatory State and Endothelial Function in Adult Subjects Belonging to the Post-Covid | UNKNOWN | nan | University of Milan | 6 minute walking test to evaluate Fatigue | nan |
| NCT05947617 | Phase 1 Study: Assessing VIX001 Safety, Efficacy, and Dosing in Post Acute COVID-19 Syndrome (PACS) Patients With Neurological Symptoms and Cognitive Impairment. | UNKNOWN | PHASE1 | Neobiosis, LLC | Change from Baseline Six Minute Walk Test (6MWT) with oximetry.; Change from Baseline Transthoracic Echocardiogram in 3 Dimensions (3-D TTE).; Change from Baseline Pulmonary Function Test (PFT) with bronchodilation if abnormal.; Change from Baseline Sleep time | PROMIS; mMRC Scale.; General Anxiety Disorder (GAD-7).; Personal Health Questionnaire Depression Scale (PHQ-8). |
| NCT05419219 | Effectiveness of Multi-domain Tai Chi Digital Therapy for Survivors Affected by the Sequelae of Covid-19 (TaiChi-DTx and Long Covid) | UNKNOWN | nan | Tim Shi | Change in Physical Activity ability measured by 6-minute walking distance measurement (6MWT); Overall respiratory relief measured by the Post-COVID-19 Functional Status (PCFS) Scale; Cognitive impairment improvement measured by the well-validated neuropsycholo | Change in number of hours/days absent from work related to Long COVID symptoms survey by web-based questionnaires (time frame 6 months after SARS-CoV-2 infection) |
| NCT05360563 | Effects of a Home-based Exercise Program on the Functional Sequelae of Patients With the Post-COVID-19 Condition: A Randomized Controlled Trial | UNKNOWN | nan | University of Sao Paulo | Change from baseline in functional fitness assessed by distance walked (m) in the six-minute walk test (6MWT) at 16 weeks. | Change from baseline in six-minute walk work (kg.km) assessed by 6MWT at 16 weeks.; Change from baseline in maximal inspiratory muscle strength (cmH2O) assessed by POWERbreathe device at 16 weeks.; Change from baseline in forced vital capacity (FVC; L) assesse |
| NCT06865261 | Effects of L-arginine and Liposomal Vitamin C Supplementation on Physical Performance and Endothelial Function in Elderly With Sarcopenia | UNKNOWN | nan | Fondazione Policlinico Universitario Agostino Gemelli IRCCS | 6MWT | HG; CST; FMD |
| NCT05543408 | Long COVID-19 Syndrome in Primary Care: A Novel Protocol of Exercise Intervention "CON-VIDA Clinical Trial" | UNKNOWN | nan | Universidad San Jorge | Change in Lower Limb Strength: 30 s Sit-to-Stand test; Change in Lower Limb Strength: 5 times Sit-to-Stand Test; Change in Handgrip Strength; Chance in upper limbs strength: Arm Curl Biceps; Change in Balance: Flamingo Balance Test; Change in walking speed: Br | Body Composition; Change in Quality of Life-SF-36; Change in The International Physical Activity Questionnaire (IPAQ); Change in Modified Medical Research Council dyspnea scale (mMRC); Change in Modified Fatigue Impact Scale (MFIS); Change in Hospital Anxiety |
| NCT ID | Title | Status | Phase | Sponsor | Primary endpoint | Secondary endpoint |
|---|---|---|---|---|---|---|
| NCT05074888 | A Multicenter, Double-blind, Placebo-controlled, Parallel-group, Randomized Clinical Trial of Efficacy and Safety of Prospekta in the Treatment of Patients With Post-COVID-19 Asthe | COMPLETED | PHASE3 | Materia Medica Holding | Change in the Mean FSS Score. | Change in Distance of the 6-minute Walk Test.; Change in the Severity of Anxiety on the HADS Subscale.; Change in the Severity of Depression on the HADS Subscale.; Change in the Mean FSS Score Within Follow-up Period.; Change in Distance of the 6-minute Walk T |
| NCT04920916 | Safety and Efficacy of the Treatment of Hospitalized Patients With COVID 19 Infection With an Inhibitor of IL-4 and IL-13 Signaling: A Phase IIa Trial | COMPLETED | PHASE2 | University of Virginia | Day 28 Ventilator Free Survival; Follow up Study 1 Year Outcome: Pulmonary Function Testing- Oxygen Diffusion and 6 Minute Walk Testing | Proportion of Patients With Eosinophilia; Cumulative Incidence of Grade 3 and 4 Clinical Adverse Events, Serious Adverse Events (SAEs) or Death; SARS-CoV-2 Variants; Change in Plasma Total Immunoglobulin E (IgE) Levels; Change in C-reactive Protein (CRP); Chan |
| NCT05592418 | A Randomized, Double Blind, Placebo Controlled Study to Evaluate the Efficacy and Safety of Ampligen® in Patients With Post-COVID Conditions | COMPLETED | PHASE2 | AIM ImmunoTech Inc. | Change From Baseline to Week 13 in PROMIS Fatigue Score (T-Score) | Change From Baseline to Week 6 in PROMIS Fatigue Score (T-Score); Change From Baseline to Week 13 in PROMIS Fatigue Score (T-Score), Excluding Response to Item Seven; Change From Baseline to Week 6 and Week 13 in Distance Traveled During 6-minute Walk Test (6M |
| NCT05121740 | Extension Study in a Cohort of Adult Patients With SARS-CoV-2 Infection Requiring Hospital Admission and Received Treatment With Plitidepsin in the APLICOV-PC Study | COMPLETED | PHASE1; PHASE2 | PharmaMar | Number and Percentage of Participants With Complications Related to Post COVID-19 Infection | Patients Requiring Oxygen Therapy; Patients With Complications Post COVID-19 Infection (Regardless Relationship, i.e. Related to COVID-19 Infection or Not).; Ratio of Partial Pressure Arterial Oxygen (PaO2) and Fraction of Inspired Oxygen (FiO2); Forced Expira |
| NCT04977388 | Phase I/II Study of NORTHERA (DROXIDOPA) for Dysautonomia in Adult Survivors of Menkes Disease and Adults With Occipital Horn Syndrome: Double-blind Placebo-controlled Randomized C | COMPLETED | PHASE1; PHASE2 | Stephen G. Kaler, MD | Treatment Related Adverse Events as Assessed by CTCAE v4.0 | Mean Change in Systolic Blood Pressure in Tilt Position; Mean Change in Diastolic Blood Pressure in Tilt Position; Plasma Catechol Levels; Change From Baseline in Daily Bowel Movements; Change From Baseline in Time Standing Duration; Change From Baseline in Ti |
| NCT05877508 | An Exploratory, Randomized, Double-Blind Placebo-Controlled Study to Assess the Safety of an Anti-SARS-CoV-2 Monoclonal Antibody and Response to Treatment in Individuals With Long | ACTIVE_NOT_RECRUITING | PHASE2 | Michael Peluso, MD | Patient-Reported Outcomes Measurement Information System (PROMIS)-29 Physical Health Summary Score | Patient-Reported Outcomes Measurement Information System (PROMIS)-29 Physical Health Summary Score; Patient-Reported Outcomes Measurement Information System (PROMIS)-29 Mental Health Summary Score; Patient-Reported Outcomes Measurement Information System (PROM |
| NCT06161688 | Placebo-Controlled, Randomized Trial of Ensitrelvir (S-217622) for Viral Persistence and Inflammation in People Experiencing Long COVID (PREVAIL-LC) | ACTIVE_NOT_RECRUITING | PHASE2 | Timothy Henrich | Patient-Reported Outcomes Measurement Information System (PROMIS)-29 Physical Health Summary Score | Patient-Reported Outcomes Measurement Information System (PROMIS)-29 Physical Health Summary Score; Patient-Reported Outcomes Measurement Information System (PROMIS)-29 Mental Health Summary Score; Patient-Reported Outcomes Measurement Information System (PROM |
| NCT05513560 | REcovering From COVID-19 Lingering Symptoms Adaptive Integrative Medicine (RECLAIM) | COMPLETED | PHASE2; PHASE3 | University Health Network, Toronto | SF-36 physical component score (PCS) | Symptoms scale; Symptom Checklist; Six Minute Walking Test (6MWT) with oximetry; TestMyBrain cognitive testing; Post COVID19 functional status scale; Reintegration to Normal Living Index (RNLI); Fatigue Scale; Brief Fatigue inventory; Post-Exertional Malaise; |
| NCT06383819 | Multicenter, Randomized, Double-blind, Placebo-controlled Parallel-group Study to Evaluate the Efficacy and Safety of Longidaza® for the Treatment of Patients With Residual Changes | COMPLETED | PHASE3 | NPO Petrovax | Change in Forced vital capacity (FVC) (visit 4) | Slowing the decline in respiratory function; Change in FVC (visit 5); The proportion of patients with an increase in the FVC (%); Dynamics of hemoglobin oxygen saturation (SpO2); The proportion of patients with SpO2 ≥ 93% and < 93%; The proportion of patien |
| NCT05152849 | A Randomized, Double-Blind, Placebo-Controlled Pilot Study to Evaluate the Efficacy, Safety, and Tolerability of AXA1125 in Subjects With Fatigue-Predominant Post-Acute Sequelae of | COMPLETED | PHASE2 | Axcella Health, Inc | Change from baseline at Week 4 in the phosphocreatine (PCr) recovery rate following moderate exercise, as assessed by 31P-magnetic resonance spectroscopy (MRS) | Change from baseline in PCr recovery rate as assessed by phosphorus magnetic resonance spectroscopy (31P-MRS); Proportion of subjects with improvement in PCr recovery rate; Change from baseline in serum lactate level after a 6-minute walk test; Proportion of s |
| NCT07492953 | Using Enhanced External Counterpulsation to Recover Cardiovascular Function for Patient of Chronic Diseases | COMPLETED | nan | National Defense Medical Center, Taiwan | Peak oxygen uptake (Peak VO₂) | The Six-Minute Walk Test (6MWT); Blood Pressure and Heart Rate; PROMIS Physical Health score; PROMIS Mental Health Score; PROMIS Sleep Disturbance Domain; Seattle Angina Questionnaire-7 (SAQ-7) summary score; COPD Assessment Test (CAT) score; Rose Dyspnea Scal |
| NCT05024474 | Effects of Inspiratory Muscle Training After Covid-19 | COMPLETED | nan | Karolinska Institutet | Change in Maximal Inspiratory Pressure (MIP) | Change in Maximal Expiratory Pressure (MEP); Change in Lung function; Change in walking distance during 6 minute walk test, expressed as percentage of predictive value,; Change in oxygen saturation during 6 minute walk test; Change in oxygen desaturation durin |
| NCT07508332 | Lung Boost Trainer Versus Incentive Spirometer on Spiro-metric Indices in Post COVID-19 Hemiplegic Cerebral Palsy Children; Randomized Controlled Trial | COMPLETED | nan | Cairo University | Pulmonary function test (PFT) :; forced vital capacity (FVC%); Forced expiratory volume (FEV1%):; FEV1/FVC ratio : | Six-minute walk test (6MWT); Short form 36 (SF-36) |
| NCT05699538 | Fatigue and Fatigability in Veterans Following SARS-CoV-2 Infection | COMPLETED | nan | VA Office of Research and Development | Performance fatigability | Rating of Perceived Fatigue (RPF); Isometric and Isokinetic Knee Extensor Torque; Skeletal muscle oxygen extraction; Feeling Scale; Fatigue Severity Scale (FSS); Short Physical Performance Battery (SPPB); 30-second sit-to-stand; Six Minute Walk Test (6MWT); Mo |
| NCT04841759 | The Effects of a Multi-factorial Rehabilitation Program for Healthcare Workers Suffering From Post-COVID-19 Fatigue Syndrome | COMPLETED | nan | Medical University of Vienna | Change of maximum oxygen uptake (VO2max) over time-points (baseline - 4 weeks - 8 weeks) assessed during cardio-pulmonary exercise testing (CPET) | Change of walking distance during a six minutes walk test (6MWT) over time-points (baseline - 4 weeks - 8 weeks); Change of numbers over time-points (baseline - 4 weeks - 8 weeks) how often someone can stand up and sit down on a chair within 30 seconds during |
| NCT06928272 | LC-REVITALIZE - A Long Covid Repurposed Drug Study | RECRUITING | PHASE3 | Douglas D. Fraser | Symptom Burden Questionnaire (SBQ) Subscales | General participant reported overall well-being using the Patient Reported Outcome Measurement Information System (PROMIS)-29 questionnaire; General participant reported overall well-being using the Generalized Anxiety Disorder (GAD)-7 questionnaire; General p |
| NCT06980636 | Shengmai Liquid for Long COVID Fatigue: a Randomized Placebo-controlled Trial. | RECRUITING | PHASE4 | Beijing University of Chinese Medicine | The degree of improvement in patient fatigue, measured using the Modified Fatigue Impact Scale (MFIS) | Traditional Chinese Medicine Syndrome Score Scale; Improvement in depression, assessed using the 17-item Hamilton Depression Scale; Improvement in anxiety, assessed using the Hamilton Anxiety Scale (HAMA); Improvement in sleep quality, assessed using the Pitts |
| NCT06631287 | Randomized Double-Blind Placebo-Controlled Trial EValuating Baricitinib on PERSistent NEurologic and Cardiopulmonary Symptoms of Long COVID (REVERSE-LC) | RECRUITING | PHASE3 | Wes Ely | CNS-Vital Signs Global Cognitive Index | Objective neuropsychological function domains of executive function, memory, processing speed, and motor speed including the CNS-Vital Signs subscale tests at 6-months.; Objective neuropsychological function domains of executive function, memory, processing sp |
| NCT04919031 | Inspiratory Muscle Trainer Impact on Post Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) COVID-19 Hypertensive Patients With Long Term Persistent Symptoms | COMPLETED | nan | Cairo University | maximal inspiratory pressure | sleeping quality scale; Timed stair climbing; 6 minute walk test; modified medical research council (mMRC) scale (0-4); Oxygen saturation; dyspnea borg scale; postural tachycardia syndrome; blood pressure (mmHg); lactate level; fatigue severity scale (0-63); P |
| NCT05894629 | Effects of an Active Coping Program in Patients With Persistent Post-Covid Pain. | COMPLETED | nan | University of Valladolid | Quality of life (QoL) | Pain Intensity; Body Chart; Quantitative sensory tests; Handgrip Strength assessment; 30 sit to stand test; 6 Minute Walking Test (6MWT); Maximal Inspiratory and Expiration Pressure (MIP/MEP); Catastrophism; Anxiety; Depression; Drug consumption.; Fatigue |
| NCT05476835 | Effect of Pulmonary Rehabilitation Program on Post Hospitalization Severe COVID- 19 Patients | COMPLETED | nan | Fayoum University Hospital | improvement in dyspnea scale; improvement in spirometry measures | improvement in oxygen saturation and 6 minute walk test |
| NCT07627815 | Phase II, Proof of Concept, Open-Label, Randomized-Controlled Trial Evaluating the Efficacy and Safety of PARAGON Novel Metabolic Regulator Formula (PNMR) in the Management of Long | RECRUITING | PHASE2 | ParagonClinicals Inc. | Change in distance walked on the 6-minute walk test (6MWT) after 6 weeks of treatment. | Change in distance walked on the 6MWT after 3 weeks of treatment.; Proportion of patients achieving an improvement of 30 meters or more on the 6MWT by 3 and 6 weeks on treatment.; Time to achieving an improvement of 30 m or more on the 6MWT by 6 weeks on treat |
| NCT05094622 | Physical Exercise in Patients With Postural Orthostatic Tachycardia Syndrome (POTS) After Covid-19. | ACTIVE_NOT_RECRUITING | nan | Karolinska Institutet | Change in Health-Related Quality of Life (HRQoL); Change in time in upright position and steps per day | Change in walking distance during 6 minute walk test; Change in oxygen saturation during 6 minute walk test; Change in oxygen desaturation during 6 minute walk test; Change in dyspnea during 6 minute walk test; Change in leg fatigue during 6 minute walk test; |
| NCT07398508 | Phase I/II Study of NORTHERA (DROXIDOPA) for Dysautonomia in Pediatric Survivors of Menkes Disease: Double-blind Placebo-controlled Randomized Crossover Clinical Trial. | RECRUITING | PHASE1; PHASE2 | Stephen G. Kaler | Incidence of SAEs | Change in level of plasma norepinephrine and dihydroxyphenylglycol after Northera (Droxidopa); Change in systolic blood pressure; Average number of daily bowel movements; Average time standing; Average 6-minute walk distance |
| NCT07021794 | Effectiveness of Treating Post-COVID-19 Conditions (Long COVID) With the SARS-CoV-2 Specific Monoclonal Antibody, Sipavibart | RECRUITING | PHASE2 | Nancy Klimas | Patient-Reported Outcomes Measurement Information System-29; Review of Treatment Related Adverse Events | Symptom-specific participant-reported outcome measures; Change in Simple Reaction Time (Milliseconds); Self-reported fatigue using MFI; Change in Heart Rate Post-6MWT; Processing Speed; Attention; Systolic Blood Pressure Response During NASA Lean Test; Diastol |
| NCT06967428 | Effectiveness of Metabolic Modulation in Treating Post-vaccination Syndrome: A Prospective Study | NOT_YET_RECRUITING | PHASE2 | Independent Medical Alliance | PAC-19QoL Questionnaire; Six-minute walk test | Hemoglobin A1c; Sedentary blood lactate; Post-exertion blood lactate; C-Reactive Protein; Spike protein levels; Resting Heart Rate Variability; Heart rate variability during 6MWT; Resting Heart Rate; Heart Rate during 6MWT; Post-exercise Borg category-ratio 10 |
| NCT06170645 | Transcutaneous Vagus Nerve Stimulation as a Complementary Therapy to Exercise in Chronic Fatigue: Single-center, Controlled, Randomized, Blinded Study | RECRUITING | nan | Centre Hospitalier Universitaire de Saint Etienne | Fatigue evaluation assessed by autonomic nervous system activity | Fatigue Severity Scale (FSS); Medical Outcome Study Short Form questionnaire (MOS-SF 12); Pittsburgh questionnaire; 6-minute walk test (6MWT); Adult Physical Activity Questionnaire (APAQ); Step count per day; Ratio of Low Frequency to High Frequency (LF/HF) |
| NCT06178952 | Transcranial Pulse Stimulation (TPS) in Post-COVID-19 | RECRUITING | nan | Medical University of Vienna | Fatigue Impact Scale (FIS) | Beck Depression Inventory (BDI-II); Montreal Cognitive Assessment (MOCA); 36-Item Short Form Health Survey (SF-36); Trail Making Test A and B (TMT-A and TMT-B); Positive and Negative Affect Schedule (PANAS); Beck Anxiety Inventory (BAI); Six Minute Walking Tes |
| NCT06829940 | Efficacy of Baduanjin Exercise in COVID-19 Contraction Patients With Idiopathic Chronic Fatigue | RECRUITING | nan | Cairo University | Pulmonary function: By Spirometry Device: | Pulmonary function: By Spirometry Device:; Measuring functional capacity: By Six-minute walk test (6MWT); Modified Borg dyspnea scale (MBDS); Strength of lower limb muscles By a thirty-second sit-to-stand test; Endurance of upper limb muscles: by the maximal r |
| NCT06452095 | RECLAIM: Recovering From COVID-19 Lingering Symptoms Adaptive Integrative Medicine Trial - Effect of Hyperbaric Oxygen Therapy for the Treatment of Post COVID Condition (RECLAIM-HB | RECRUITING | nan | University Health Network, Toronto | Simple reaction time [SRT] task from the TestMyBrain (TMB) Digital Neuropsychology Toolkit; Verbal paired associates [VPA] task from the TestMyBrain (TMB) Digital Neuropsychology Toolkit | Symptoms scale; Symptom Checklist; Six Minute Walking Test (6MWT) with oximetry; SF-36; TestMyBrain cognitive testing; Post COVID19 functional status scale; Reintegration to Normal Living Index (RNLI); The Fatigue Scale; Brief Fatigue inventory; Post-Exertiona |
| NCT05877534 | Effects of Individual Tailored Physical Exercise in Patients With Post COVID-19 Condition, Diagnosed With Postural Orthostatic Tachycardia Syndrome (POTS) - a Randomized Controlled | ENROLLING_BY_INVITATION | nan | Karolinska Institutet | Change in time in upright position and steps per day; Change in Health-Related Quality of Life (HRQoL) | Change in walking distance during 6 minute walk test; Change in oxygen saturation during 6 minute walk test; Change in dyspnea during 6 minute walk test; Change in leg fatigue during 6 minute walk test; Change in exertion during 6 minute walk test; Change in h |
| NCT04949386 | A Randomized, Placebo-Controlled Phase II Study To Evaluate The Safety, Tolerability And Efficacy Of S-1226 In Post-Covid-19 Subjects With Persistent Respiratory Symptoms. | UNKNOWN | PHASE2 | SolAeroMed Inc. | Treatment Emergent Adverse Effects | Normalization in 6-minute walk test (6MWT) distance; Changes in percent predicted forced expiratory volume in 1 second; Changes in from baseline in respiratory symptoms assessed by the St George's Respiratory Questionnaire (SGRQ). |
| NCT06231225 | Study on the Effect of Incentive Spirometer-based Respiratory Training on the Long COVID-19 Symptoms in Chronic Disease Patients After Recovery From COVID-19 | NOT_YET_RECRUITING | nan | National Taipei University of Nursing and Health Sciences | Post-COVID-19 Functional Status scale | Lung function indices; Hemoglobin and oxygen levels; Six-minute walk test (6MWT); Dyspnoea-12 (D-12) scale |
| NCT06074848 | Transcranial Direct Current Stimulation as a Strategy for the Management of Disorders Generated by COVID-19: a Multicentric Study. | UNKNOWN | PHASE2 | Universidade Federal de Pernambuco | Fatigue - Modified Fatigue Impact Scale (MFIS); Pain measure - Brief Pain Inventory (BPI); Pain measure - Visual Analog Scale (VAS); Cognitive deficit - Montreal Cognitive Assessment Instrument (MoCA); Cognitive deficit - FAS Test; Cognitive deficit - CFL Test | COVID clinical situation; Level of physical activity; State of strength and effort; Exercise capacity - 6-minute walk test; Immunometabolic evaluation |
| NCT04482595 | A Phase 2 Study of BIO 300 Oral Suspension in Discharged COVID-19 Patients | UNKNOWN | PHASE2 | Humanetics Corporation | Change in DLCO | Change in 6 Minute Walk Test; Change in FVC; Change in St. George's Respiratory Questionnaire (SGRQ) Scores; Change in Pulmonary Fibrosis on HRCT Scan; Incidence of Re-Hospitalization; All-Cause Mortality; Change in FEV1; Change in FEV1/FVC Ratio; Change |
| NCT05629793 | Differential Diagnosis of Persistent COVID-19 by Artificial Intelligence | UNKNOWN | nan | Fundacin Biomedica Galicia Sur | Differences of the group of patients with a persistent diagnosis of COVID from the age-matched group, sex and vaccination status of patients recovered from COVID without sequelae. | Cardiac variability; Voice recording; Skin conductance; 6MWT; 1minSTST; Cold Pressor test |
| NCT05539950 | Cardiopulmonary Rehabilitation in Post-acute COVID-19 Syndrome | WITHDRAWN | nan | Taipei Medical University Shuang Ho Hospital | Changes in Cardiopulmonary exercise testing (CPET) | Changes in 6 minutes walking test (6MWT); Changes in Pulmonary function test (PFT); Changes in 36-Item Short Form Survey (SF-36) |
| NCT05669261 | A PILOT STUDY ON RESEARCH TREATMENT OF LONG COVID POST-ACUTE SEQUELAE OF SARS CoV-2 INFECTION ("PASC") USING ATCell™ | UNKNOWN | PHASE1 | American CryoStem Corporation | Assessment of the Incidence of Serious Adverse Events (SAEs); Assessment of change in Health Status using the 36 item Short Form Health Survey (SF-36); Assessment of change in Health Status using the 36 item Short Form Health Survey (SF-36); Assessment of chan | Assessment of Changes in Exosome/Cytokine/Chemokine Testing; Assessment of change in completion time -Six-minute walk test (6MWT); Assessment of Change in Complete blood count with differential (CBC with diff) Laboratory Testing Results; Assessment of Change i |
| NCT06091358 | Does a 4-week Inspiratory Muscle Training Intervention (IMT) Increase Inspiratory Muscle Pressure (MIP) and Other Functional Outcomes in People With Long COVID? A Pilot Investigati | UNKNOWN | nan | University of Bath | Change in Maximal inspiratory muscle pressure (MIP) at week 4. | Change in Peak expiratory flow (PEF) at week 4.; Change in Ventilatory threshold (VT) at week 4.; Difference between Baseline Dyspnea Index score (BDI) and Transitional Dyspnea index (TDI).; Change in 6 minute walk test distance at week 4; Change in Forced ven |
| NCT05360563 | Effects of a Home-based Exercise Program on the Functional Sequelae of Patients With the Post-COVID-19 Condition: A Randomized Controlled Trial | UNKNOWN | nan | University of Sao Paulo | Change from baseline in functional fitness assessed by distance walked (m) in the six-minute walk test (6MWT) at 16 weeks. | Change from baseline in six-minute walk work (kg.km) assessed by 6MWT at 16 weeks.; Change from baseline in maximal inspiratory muscle strength (cmH2O) assessed by POWERbreathe device at 16 weeks.; Change from baseline in forced vital capacity (FVC; L) assesse |
| NCT06063031 | Investigation of a Specialized Nutritional Intervention and Rehabilitation Treatment in Patients With Post-COVID Condition to Improve Their Quality of Life: ARACOV-02 | UNKNOWN | nan | Instituto de Investigación Sanitaria Aragón | Changes in the Quality of life (EQ-5D) | Changes in the Biomarkers; Changes in the Fatigue Severity Scale (FSS); Changes in the Modified Medical Research Council Scale (mMRC); Changes in the Measurements of peak inspiratory pressure and peak expiratory pressure; Changes in the Functional capacity as |
| NCT05749757 | The Efficacy and Safety of Acupuncture for Post COVID-19 Fatigue: a Randomized Controlled Trial | UNKNOWN | nan | Guang'anmen Hospital of China Academy of Chinese Medical Sciences | The change from baseline in the Chalder Fatigue Scale (CFS) score | The change from baseline in the Chalder Fatigue Scale (CFS) score; Proportion of participants with a score of less than 15 on CFS; The change from baseline in the distance of Six-Minute Walk Test (6MWT).; The proportion of participants rated as "very much |
| NCT ID | Title | Status | Phase | Sponsor | Primary endpoint | Secondary endpoint |
|---|---|---|---|---|---|---|
| NCT05524532 | Effect of Immulina Supplements on Inflammatory Biomarkers Correlated With Clinical Symptoms in Patients With Long COVID (PASC) | COMPLETED | PHASE3 | University of Mississippi Medical Center | Plasma IL-6 (Interleukin 6, pg/mL); Plasma CRP (C-Reactive Protein, ng/mL); Plasma D-Dimer, pg/mL | PROMIS-29; FSS; SBQ-LC TM; SARS-CoV-2-specific antibody responses; SARS-CoV-2-specific immune responses on memory T cell levels; SARS-CoV-2-specific immune responses on memory B cell levels; Natural Killer cell (NK)-mediated cytotoxicity; Natural Killer (NK) c |
| NCT06419712 | Effect of Vitamin D Supplementation on Glutathione Peroxidase (GPx) Activity, Interleukin-6 (IL-6) Levels and Clinical Outcomes in Post-COVID-19 Patients | COMPLETED | nan | Escuela Militar de Graduados de Sanidad, SEDENA | Glutathione Peroxidase (GPx) Activity; Serum Levels of Interleukin-6 (IL-6) | Lung Function Tests; Neuropsychiatric Symptoms (Anxiety and Depression) |
| NCT06004310 | Effect of Pulmonary Rehabilitation Among Post-COVID-19 Patients in a Tertiary Care Hospital in Bangladesh: A Quasi-Experimental Study | COMPLETED | nan | Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh | Distance: Six-minute walking test (6MWT); Respiratory outcomes: FVC, FEV1, FEV1/FVC ratio, DLCO; Quality of life: Short Form 36 Health Survey Questionnaire (SF-36); Laboratory investigations: CRP and D-dimer | nan |
| NCT05848518 | Effect of Different Types of Supervised Exercise Programs on Cardiorespiratory and Muscular Fitness, Pain, Fatigue, Mental Health and Inflammatory and Oxidative Stress Biomarkers i | COMPLETED | nan | Campus docent Sant Joan de Déu-Universitat de Barcelona | Cardiorespiratory fitness: absolute oxygen uptake; Cardiorespiratory fitness: relative oxygen uptake; Cardiorespiratory fitness: ventilation; Cardiorespiratory fitness: ventilatory equivalent for oxygen; Cardiorespiratory fitness: ventilatory equivalent for ca | nan |
| NCT06064838 | Effects of Cacao Flavonoids in Long COVID-19 Patients with Chronic Fatigue (FLALOC) | COMPLETED | nan | Guillermo Ceballos Reyes | Interleukin-1b; Interleukin-6; TNF-alpha; Syndecan-1 | EQ-5D questionnaire; Analog Visual Scale; Numerical fatigue rating scale; Handgrip strength |
| NCT05356936 | Pilot Study of Vitamin K2 (MK-7) and Vitamin D3 Supplementation and the Effects on PASC Symptomatology and Inflammatory Biomarkers | COMPLETED | nan | University Hospitals Cleveland Medical Center | Change in high-sensitivity C-reactive protein (hs-CRP) as measured by blood test; Change in interleukin 6 (IL-6) as measured by blood test; Change in intestinal fatty acid binding protein (Ifab) as measured by blood test; Change in soluble Tumor Necrosis Facto | Percent of subjects with >Grade 2 adverse events as measured by patient report |
| NCT06211062 | The Use of Directed Probiotics in ME/CFS: Myalgic Encephalomyelitis/Chronic Fatigue Syndrome | RECRUITING | PHASE2 | Nova Southeastern University | The Incidence of Intervention-Related Adverse Events [Safety]; The Measurement of Biomarker Response to an Intervention in the Blood [Efficacy]; level of CRP (C-reactive protein); The pro-inflammatory cytokines level e.g. IL-1, IL-6, and TNF-α; The Symptom Sev | The Impact on the Irritable Bowel Syndrome (IBS) Severity; The IBS-related Quality of Life Measurement |
| NCT04813718 | Post COVID-19 Syndrome: A Pilot Study to Explore the Gut-lung Axis | ACTIVE_NOT_RECRUITING | nan | Medical University of Graz | Microbiome composition; Intestinal barrier; sCD14; endotoxin; TNFalpha; Interleukin 1b; Interleukin 6; Interleukin 6 receptor; interleukin 8; interleukin 10; interleukin 17; interleukin 23; neutrophil function burst function; neutrophil function phagocytosis; | nan |
| NCT07197138 | Pilot Study on the Effects of Intensified Repetitive Transcranial Magnetic Stimulation on Immunological Blood Parameters in Patients With Depression and Comorbid Post-COVID-19 Cond | RECRUITING | nan | Max-Planck-Institute of Psychiatry | Change in immunophenotypic marker CRP from baseline to post-treatment; Change in immunophenotypic marker TNF from baseline to post-treatment; Change in immunophenotypic marker IL-1ß from baseline to post-treatment; Change in immunophenotypic marker IL-6 from b | Change in Fatigue Severity Scale (FSS, self-rating); Change in Fatigue Scale for Motor and Cognitive Functions (FSMC, self-rating); Change in Post-Exertional Malaise (PEM) Questionnaire (self-rating); Change in Pittsburgh Sleep Quality Index (PSQI, self-rating |
| NCT05421208 | Cardiovascular Autonomic and Immune Mechanism of Post COVID-19 Tachycardia Syndrome | RECRUITING | nan | Vanderbilt University Medical Center | IL-6 levels | Orthostatic Symptoms Score |
| NCT06027255 | Long COVID Immune Profiling | RECRUITING | nan | Vanderbilt University Medical Center | IL-6 levels | Orthostatic Symptoms Score; cytokines (IL-17, and IFN-ɣ) |
| NCT05271500 | Effect of Laser Acupuncture on Immunological Response and Dyspnea in Post Covid Syndrome Patients | UNKNOWN | nan | Cairo University | change in the level of CD 3 T cells; change in the level of cd4 T cells; change in level of interleukin 4; change in level of interleukin 6; change in lymphocyte count; change in level of dyspnea | change in fatigability |
| NCT ID | Title | Status | Phase | Sponsor | Primary endpoint | Secondary endpoint |
|---|---|---|---|---|---|---|
| NCT04920916 | Safety and Efficacy of the Treatment of Hospitalized Patients With COVID 19 Infection With an Inhibitor of IL-4 and IL-13 Signaling: A Phase IIa Trial | COMPLETED | PHASE2 | University of Virginia | Day 28 Ventilator Free Survival; Follow up Study 1 Year Outcome: Pulmonary Function Testing- Oxygen Diffusion and 6 Minute Walk Testing | Proportion of Patients With Eosinophilia; Cumulative Incidence of Grade 3 and 4 Clinical Adverse Events, Serious Adverse Events (SAEs) or Death; SARS-CoV-2 Variants; Change in Plasma Total Immunoglobulin E (IgE) Levels; Change in C-reactive Protein (CRP); Chan |
| NCT05877508 | An Exploratory, Randomized, Double-Blind Placebo-Controlled Study to Assess the Safety of an Anti-SARS-CoV-2 Monoclonal Antibody and Response to Treatment in Individuals With Long | ACTIVE_NOT_RECRUITING | PHASE2 | Michael Peluso, MD | Patient-Reported Outcomes Measurement Information System (PROMIS)-29 Physical Health Summary Score | Patient-Reported Outcomes Measurement Information System (PROMIS)-29 Physical Health Summary Score; Patient-Reported Outcomes Measurement Information System (PROMIS)-29 Mental Health Summary Score; Patient-Reported Outcomes Measurement Information System (PROM |
| NCT04938687 | Pilot, Effect of Respiratory-Gated Auricular Vagal Afferent Nerve Stimulation (RAVANS) on Post-Treatment Lyme Disease Syndrome | COMPLETED | nan | Spaulding Rehabilitation Hospital | Horowitz Lyme-Multiple Systemic Infectious Disease Syndrome Questionnaire | Sedentary Behaviors Questionnaire; Fatigue Symptom Inventory; Brief Pain Inventory-Pain 24 Hours; Beck Depression Inventory; Beck Anxiety Inventory; Pittsburgh Sleep Quality Index; Timed Up and Go; Time to Complete 4 Meters at Usual Walking Speed,; NIH Toolbox |
| NCT05890534 | Pycnogenol® in People With Post-COVID-19 Condition: a Quadruple-blind, Randomized, Placebo-controlled Trial | COMPLETED | PHASE3 | University of Zurich | Health status (EQ-VAS) | Post COVID-19 symptoms; Fatigue; Dyspnea; Cognitive function; Anxiety and depression; Health-related quality of life (EQ-5D-5L); Functional exercise capacity; Physical activity; Soluble Thrombomodulin (sTM); von Willebrand Factor antigen (VWF:Ag); Syndecan-1; |
| NCT05228899 | A Phase I/II Multicenter, Randomized, Double Blinded, Placebo Trial to Evaluate the Safety and Potential Efficacy of Zofin Infused Intravenous (IV) in Patients Experiencing Prolong | COMPLETED | PHASE1; PHASE2 | ZEO ScientifiX, Inc. | Incidence of Severe Adverse Events | Fatigue Severity Score Score; Daily Diary of COVID-19 Related Symptom; COVID-19 Associated Symptoms Length; COVID-19 Associated Symptoms Mitigation; Beck Depression Inventory Score; Mental Fatigue Questionnaire Score; Pulse Oxygen Saturation; Heart Rate Variab |
| NCT04841759 | The Effects of a Multi-factorial Rehabilitation Program for Healthcare Workers Suffering From Post-COVID-19 Fatigue Syndrome | COMPLETED | nan | Medical University of Vienna | Change of maximum oxygen uptake (VO2max) over time-points (baseline - 4 weeks - 8 weeks) assessed during cardio-pulmonary exercise testing (CPET) | Change of walking distance during a six minutes walk test (6MWT) over time-points (baseline - 4 weeks - 8 weeks); Change of numbers over time-points (baseline - 4 weeks - 8 weeks) how often someone can stand up and sit down on a chair within 30 seconds during |
| NCT05531019 | COVID-19 Sequelae: Treatment and Monitoring of Persistent Symptoms, a Decentralized Approach Focus on the Patient. Use of Dietary Supplement Based on Sea Urchin Eggs With Echinochr | COMPLETED | nan | Fernando Saldarini | Change of symptoms over time-points (baseline, 4 weeks, 8 weeks, 12 weeks) during rutine medical checkup.; Change of lung capacity over four times (baseline, 4 weeks, 8 weeks, 12 weeks) assessed during spirometry.; Change of walking distance during a six minut | Change of Von Willebrand Factor over time-points (baseline, 4 weeks, 12 weeks, 12 weeks) via blood sample.; Change of D Dimer over time-points (baseline, 4 weeks, 12 weeks, 12 weeks) via blood sample.; Change of HS-CRP over time-points (baseline, 4 weeks, 8 we |
| NCT04718506 | Rehabilitation for Post-COVID-19 Syndrome Through a Multicomponent, Educational and Supervised Exercise Intervention [RECOVE] | COMPLETED | nan | Universidad de Murcia | Changes in subject clinical status | Changes in cardiovascular fitness: Maximal oxygen consumption (VO2max); Changes in neuromuscular performance during resistance exercise: Barbell Mean Propulsive Velocity (MPV); Changes in balance: center of pressure (COP) sway; Changes in pulmonary function: F |
| NCT06597396 | A Phase 2a Randomized, Dose Ranging, Double-Blind, 3-Arm Study to Investigate Orally Administered Abrocitinib Compared With Placebo in Non-Hospitalized Symptomatic Adult Participan | ACTIVE_NOT_RECRUITING | PHASE2 | Beth Israel Deaconess Medical Center | Change from baseline in mean score for FACIT (Functional Assessment of Chronic Illness Therapy) Fatigue Scale | Change from baseline for EQ(EuroQol)-5D-5L values and visual analog scale (VAS) score to Day 84; Change from baseline in PASC Symptom PRO (patient reported outcome) Instrument score to Day 84; Safety-related clinical laboratory test abnormalities and related a |
| NCT05204511 | Exercise and Post-COVID/Long-COVID: Effects of Different Training Modalities on Physical Performance, Heart Rate Variability, Inflammation, Health-Related Quality of Life, Cognitiv | COMPLETED | nan | University of Vienna | Change of peak oxygen consumption (VO2peak measured in ml/min/kg) | Change of maximum lower body isometric muscle strength (measured in N); Change of maximum hand grip strength (measured in kg); Change of Standard Deviation of RR-Intervals (SDNN measured in ms); Change of Root Mean Square of Successive Differences (RMSSD measu |
| NCT06294756 | Effects of Sulfurous Thermal Waters Inhalations on Long-COVID Syndrome: a Double-blinded, Interventional, Randomized Case-control, Pilot Study on a Spa Centered Rehab Program | COMPLETED | nan | University of Roma La Sapienza | To determine whether Sulfurous Thermal water (STW) inhalations may have effects on post covid-pulmonary sequelae assessing changes in pulmonar functionality through spirometric parameters.; To determine whether Sulfurous Thermal water (STW) inhalations may hav | To assess if H2S present in STW can interfere with concentration of inflammatory markers ( as IL1B, IL-6, ACE, S100B, GSS, Hs-CRP) typically alterated in long covid patients.; To assess if H2S present in STW can interfere with concentration of inflammatory mar |
| NCT05630040 | Vagus Nerve Simulation for Long-COVID-19 | COMPLETED | nan | Icahn School of Medicine at Mount Sinai | Composite Dysautonomia Symptom Score (COMPASS 31); Composite Dysautonomia Symptom Score (COMPASS 31); Composite Dysautonomia Symptom Score (COMPASS 31); Composite Dysautonomia Symptom Score (COMPASS 31); Composite Dysautonomia Symptom Score (COMPASS 31) | Fatigue Severity Scale (FSS); Fatigue Severity Scale (FSS); Fatigue Severity Scale (FSS); Fatigue Severity Scale (FSS); Fatigue Severity Scale (FSS); Neuro Quality of Life Score; Neuro Quality of Life Score; Neuro Quality of Life Score; Neuro Quality of Life S |
| NCT06073002 | Effects of a Home-Based Exercise Intervention on Physical Function, Symptoms and Health-Related Quality of Life in Subjects with Long Covid | ACTIVE_NOT_RECRUITING | nan | University of Vienna | Change of peak oxygen consumption (VO2peak measured in ml/min/kg) | Change of maximum lower body isometric muscle strength (measured in N); Change of maximum hand grip strength (measured in kg); Change of Standard Deviation of RR-Intervals (SDNN measured in ms); Change of Root Mean Square of Successive Differences (RMSSD measu |
| NCT05227170 | Impact of Lp299v on Vascular Function in Patients With PASC | ACTIVE_NOT_RECRUITING | nan | Medical College of Wisconsin | Brachial Artery Flow Mediated Dilation (FMD%) | Nitroglycerin-Mediated Vasodilation of the brachial artery (NMD); Hyperemic Flow Velocity; Carotid-Femoral Pulse Wave Velocity (cfPWV); Percentage of Laser Doppler Signal; interleukin-6; Stool microbiota alpha diversity; Stool microbiota beta diversity; Cell-F |
| NCT04695704 | Double-blind Randomized Clinical Trial, Placebo-controlled to Assess the Efficacy of Montelukast in Mild-moderate Respiratory Symptoms in Patients With Long-COVID-19: E-SPERANZA CO | TERMINATED | PHASE3 | Fundacio d'Investigacio en Atencio Primaria Jordi Gol i Gurina | COP Assessment Test Scale (CAT) | 1min sit-to-stand test; O2 desaturation; Visual Analogical Scale (VAS); All-cause mortality; Number of visits to primary care; Number of visits to the emergency room; Number of hospital admissions.; Medication side effects; Days of sick leave; Factors of infla |
| NCT06967428 | Effectiveness of Metabolic Modulation in Treating Post-vaccination Syndrome: A Prospective Study | NOT_YET_RECRUITING | PHASE2 | Independent Medical Alliance | PAC-19QoL Questionnaire; Six-minute walk test | Hemoglobin A1c; Sedentary blood lactate; Post-exertion blood lactate; C-Reactive Protein; Spike protein levels; Resting Heart Rate Variability; Heart rate variability during 6MWT; Resting Heart Rate; Heart Rate during 6MWT; Post-exercise Borg category-ratio 10 |
| NCT04712279 | High-Dose Ivermectin for Mild-to-Moderate COVID-19 - The (HD)IVACOV Trial | UNKNOWN | PHASE2; PHASE3 | Corpometria Institute | World Health Organization (WHO) Clinical Progression Scale [0 to 10; 0 = uninfected; 10 = death] | World Health Organization (WHO) COVID=19 Ordinal Scale for Clinical Improvement [1 to 8; 1 = not hospitalized, no limitation on activities; 8 = death] [Time Frame: Day 7]; Time-to-recovery; Viral load; Positivity rate of rtPCR-SARS-CoV-2 (qualitative analysis) |
| NCT07278206 | Mitigating Cognitive Problems and Fatigue With Brain Stimulation in Long COVID | RECRUITING | nan | Amsterdam UMC, location VUmc | Fatigue | Objective cognitive functioning; Arterial Spin Labeling (ASL); Magnetic Resonance Spectroscopy (MRS); Functional Magnetic Resonance Imaging (fMRI); Actigraphy; Short physical performance battery (SPPB); Simple Reaction Time (SRT); Effort-based decision task; N |
| NCT06920628 | PET Imaging of Cyclooxygenase-1 in Participants With Neurological Manifestations of Post-Acute Sequelae of SARS-CoV-2 Infection (PASC) | RECRUITING | PHASE1 | National Institute of Mental Health (NIMH) | To measure distribution volume for 11C-PS13 | Voxel-wise correlation of distribution volume between healthy volunteers and Neuro-PASC participants; Correlation of Distribution Volume with CRP; Correlation of Distribution Volume with Finger Tapping Speed; Correlation of Distribution Volume with Clinical Im |
| NCT06292377 | Better Understanding of Fatigue After STroke | RECRUITING | nan | Brugmann University Hospital | Heart rate variability (HRV); Heart rate variability (HRV); Heart rate variability (HRV); Transthoracic echography (TTE); Transthoracic echography (TTE); Transthoracic echography (TTE); Fatigue Severity Scale (FSS-7); Fatigue Severity Scale (FSS-7); N-terminal | Blood CRP level; Blood neutrophil-to-lymphocyte ratio (NLR); Stroke localization in the brain; Fazekas scale; Global cortical atrophy scale; Informant Questionnaire on Cognitive Decline in the Elderly (IQCODE); Presence for pre-existing fatigue (yes/no); Durat |
| NCT07285707 | Acupuncture for Long COVID - A Pragmatic Pilot Study | RECRUITING | nan | Southern California University of Health Sciences | Feasibility of Implementing a Combined Acupuncture and Chinese Herbal Medicine Intervention for long COVID | Patient-Reported Acceptability of the Study Procedures and Treatments; Clinician-Reported Acceptability of the Study Protocol; Change in Health-Related Quality of Life Measured by PROMIS-29 v2.1; Change in Symptom Burden Measured by the Symptom Burden Question |
| NCT05890599 | Randomized Multicenter Clinical Trial: Yoga Versus Health Education for the Treatment of Persistent Fatigue in Patients With Post COVID-19 Syndrome | RECRUITING | nan | University Hospital Tuebingen | Fatigue | Fatigue; Health related quality of life SF-12; Health related quality of life SF-12; Health related quality of life EQ-5D-5L; Health related quality of life EQ-5D-5L; Psychological symptoms; Psychological symptoms; Sleep quality; Sleep quality; Stress; Stress; |
| NCT06953661 | Ultrasound Guided Stellate Ganglion Block in Postural Tachycardia Syndrome: A Randomized Double Blind Sham Placebo-controlled Pilot Study | NOT_YET_RECRUITING | nan | Stanford University | COMPASS 31 total score | Magnitude of postural tachycardia; Heart rate variability (HRV); Plasma catecholamine levels; Survey of Postural Orthostatic Tachycardia Syndrome Symptoms (SPOTS); VOSS score; FSS score; PROMIS Cognitive Function Short Form 6a; EQ-5D score; PGI-S rating; PGI-C |
| NCT06597682 | A Randomized Controlled Basket Study for Evaluating Immunomodulatory Interventions in Post-Acute Sequelae of SARS-CoV-2 InfEction (RISE) | NOT_YET_RECRUITING | nan | Huashan Hospital | Inflammatory Cardiac Involvement symptom cluster: cardiac magnetic resonance (CMR) indicators; Cough symptom cluster: Leicester Cough Questionnaire (LCQ) scale scores; Fatigue symptom cluster: Fatigue Severity Scale (FSS) scale scores | Inflammatory Cardiac Involvement symptom cluster: other relevant cardiac magnetic resonance (CMR) indicators; Inflammatory Cardiac Involvement symptom cluster: VO2max; Inflammatory Cardiac Involvement symptom cluster: Kansas City Cardiomyopathy Questionnaire ( |
| NCT06065033 | Exercise as a Therapeutic for Those Diagnosed With Post-acute Sequelae of Covid-19 | WITHDRAWN | nan | University of Virginia | VO2peak; Left ventricular strain; Left ventricular diastolic function | Forced expiratory volume in one second (FEV1); Forced vital capacity (FVC); Post COVID-19 Functional Status scale; Symptom Burden Questionnaire for Long Covid (SBQ-LC); International Physical Activity Questionnaire (IPAQ); NTproBNP; C-reactive protein (CRP); L |
| NCT05445531 | Low-field Magnetic Resonance Imaging to Assess Changes in Pulmonary Function Parameters in Confirmed Pediatric SARS-CoV-2 Infection | UNKNOWN | nan | University of Erlangen-Nürnberg Medical School | Functional lung assessment (LF-MRI) | Morphologic lung assessment (LF-MRI); Cardiological functional diagnostics (VO2); Cardiological functional diagnostics (VO2max); Cardiological functional diagnostics (VT2); Cardiological functional diagnostics (VCO2); Cardiological functional diagnostics (HR); |
| NCT ID | Title | Status | Phase | Sponsor | Primary endpoint | Secondary endpoint |
|---|---|---|---|---|---|---|
| NCT03674541 | The Exercise Response to Pharmacologic Cholinergic Stimulation in Myalgic Encephalomyelitis / Chronic Fatigue Syndrome | COMPLETED | PHASE2 | Brigham and Women's Hospital | Change in Peak Oxygen Uptake (Peak VO2) Between the First and Second iCPET | Peak-Rest Oxygen Uptake (VO2); Peak Cardiac Output (Qc); Peak-Rest Cardiac Output (Qc); Peak Right Atrial Pressure (RAP); Peak-Rest Right Atrial Pressure (RAP); Peak Pulmonary Arterial Wedge Pressure (PAWP); Peak Stroke Volume (SV); Peak (Ca-vO2)/[Hgb]; Ventil |
| NCT06840873 | Effectiveness of a 8-week Tele-Rehabilitative Exercise Training Program on Fatigue, Symptom Severity, and Quality of Life in Nurses With Long COVID: A Randomized Controlled Trial | COMPLETED | nan | Shang-Lin Chiang | Fatigue (score); O2 pulse in ml/beat; Aerobic capacity (VO2 max in ml/kg/min ); Working load in watt; Heart rate recovery in beat/min; Anaerobic threshold (AT in ml/kg/min); Severity of long COVID symptoms (scores) | Quality of life (scores); Perceived stress (scores) |
| NCT05866224 | Effects of a Telerehabilitation Program and Detraining on Cardiorespiratory Fitness in Patients With Post-COVID-19 Sequelae | COMPLETED | nan | Campus docent Sant Joan de Déu-Universitat de Barcelona | Cardiorespiratory fitness: absolute oxygen uptake; Cardiorespiratory fitness: relative oxygen uptake; Exercise capacity during cardiopulmonary exercise test; Mechanical efficiency; Ventilatory efficiency; Power output during pedaling | Respiratory exchange ratio; Minute ventilation; ventilatory equivalent for oxygen; ventilatory equivalent for carbon dioxide; End-tidal partial pressure of oxygen; end-tidal partial pressure of carbon dioxide; Weight of COVID-19 patients; Height of COVID-19 pa |
| NCT04841759 | The Effects of a Multi-factorial Rehabilitation Program for Healthcare Workers Suffering From Post-COVID-19 Fatigue Syndrome | COMPLETED | nan | Medical University of Vienna | Change of maximum oxygen uptake (VO2max) over time-points (baseline - 4 weeks - 8 weeks) assessed during cardio-pulmonary exercise testing (CPET) | Change of walking distance during a six minutes walk test (6MWT) over time-points (baseline - 4 weeks - 8 weeks); Change of numbers over time-points (baseline - 4 weeks - 8 weeks) how often someone can stand up and sit down on a chair within 30 seconds during |
| NCT07190105 | Impact of Vagal Approaches on Symptomatology in Long COVID Participants | COMPLETED | nan | Leidos Life Sciences | Patient Health Questionnaire-8 (PHQ-8); Generalized Anxiety Disorder-7 (GAD-7); PTSD Checklist for DSM-5 Short Form (Abbreviated PCL-5); Symptom Burden Questionnaire - Long COVID (SBQ-LC); Body Perception Questionnaire (BPQ); Benefits Scale; Sleep Metrics; Res | nan |
| NCT04740736 | Cardiovascular Analysis of Post-exertional Malaise | COMPLETED | nan | Icahn School of Medicine at Mount Sinai | CPET testing; Total Blood Volume; Hypovolemia | nan |
| NCT05922865 | Tri-service General Hospital, National Defence Medical Center, Taipei, Taiwan | COMPLETED | nan | Shang-Lin Chiang | Aerobic capacity (VO2 max in ml/kg/min ); Anaerobic Threshold (mL/kg/min); Working load in watt; Breathing reserve (ml/kg/min); Rest Heart rate in beat/min; O2 pulse in ml/beat; Systolic blood pressure in mm Hg; Diastolic blood pressure in mm Hg; VE/VCO2 slope | Quality of life (scores); Sleeping Quality (scores); Body composition: Body weight (kg); Body composition: Body fat (%); Body composition: Lean mass weight (kg) |
| NCT06251011 | Effects of Physiotherapy Via Telerehabilitation on Cardiopulmonary, Physical, and Psychological Functions in Patients With COVID-19: A Randomized Controlled Trial | COMPLETED | nan | Chulabhorn Hospital | Cardiopulmonary function; Patient's quality of life; Functional capacity; Anxiety and depression; Insomnia; Cognitive function; Muscle strength | nan |
| NCT06933017 | Feasibility Study of the Augmented Two-Day 6-Minute Incremental Step Test and Causal Exploration Through a Directed Acyclic Graph and Structural Equation Model for Post-Exertional | COMPLETED | nan | Universitair Ziekenhuis Brussel | Difference in oxygen uptake at peak (VO2 peak) between day 1 and day 2 measured with the CPET compared to measured with the Calibre device; Difference in Rate of Perceived Exertion (RPE) measured with the CPET compared to measured with the Calibre device; Rest | Change from Day 1 to Day 2 in Oxygen Uptake at First Ventilatory Threshold (VO₂ in ml/min/kg) during experimental session 1 or 2 (CPET); Change from Day 1 to Day 2 in Oxygen uptake at peak (VO2 in ml/min/kg) during experimental session 1 and 2 (CPET & 6MIS |
| NCT06294756 | Effects of Sulfurous Thermal Waters Inhalations on Long-COVID Syndrome: a Double-blinded, Interventional, Randomized Case-control, Pilot Study on a Spa Centered Rehab Program | COMPLETED | nan | University of Roma La Sapienza | To determine whether Sulfurous Thermal water (STW) inhalations may have effects on post covid-pulmonary sequelae assessing changes in pulmonar functionality through spirometric parameters.; To determine whether Sulfurous Thermal water (STW) inhalations may hav | To assess if H2S present in STW can interfere with concentration of inflammatory markers ( as IL1B, IL-6, ACE, S100B, GSS, Hs-CRP) typically alterated in long covid patients.; To assess if H2S present in STW can interfere with concentration of inflammatory mar |
| NCT06366724 | LIFT: Life Improvement Trial | RECRUITING | PHASE2 | Brigham and Women's Hospital | Functional Capacity; Physiologic Response - Oxygen Uptake Efficiency Slope (OUES); Physiologic Response - Oxygen Utilization (VO2); Physiologic Response - Heart Rate Recovery (HRR) | Post-Exertional Malaise; PROMIS-29-Pain; Daily Activity; Heart Rate Variability; Blood Oxygen; Resting Heart Rate; DANA Brain Vital-Simple Reaction Time (SRT); DANA Brain Vital-Procedural Reaction Time (PRT); DANA Brain Vital-Memory Search (MS) |
| NCT05530317 | CArdiac REhabilitation for Building Exertional heArt Rate for Chronotropic Incompetence in Long COVID-19 (CARE BEAR-LC): A Proof-of-Concept, Mechanistic Trial | RECRUITING | nan | University of California, San Francisco | Change in adjusted heart rate reserve; Change in Peak VO2 (ml/kg/min) | Change in Peak VO2 (percent predicted); Number of Cardiac Rehabilitation sessions attended; Change in Proportion with peak VO2 less than 85% predicted; Change in Number of Long COVID symptoms; Change in Composite Autonomic Symptom Scale-31 (Compass 31) Score; |
| NCT07621068 | Hyperbaric Oxygen Therapy for Chronic Fatigue Syndrome (CFS) - A Prospective, Randomized, Double-Blind, Sham-Controlled Study | NOT_YET_RECRUITING | nan | Assaf-Harofeh Medical Center | Cardiopulmonary exercise test (CPET) | DePaul Post-Exertional Malaise Questionnaire (DPEMQ); Short Form-36 Health Survey (SF-36); Pittsburgh Sleep Quality Index (PSQI); Brief Symptom Inventory-18 (BSI-18); Montreal Cognitive Assessment (MoCA); NeuroTrax; Brain MRI; Brain EEG; Sleep EEG; Orthostatic |
| NCT05539950 | Cardiopulmonary Rehabilitation in Post-acute COVID-19 Syndrome | WITHDRAWN | nan | Taipei Medical University Shuang Ho Hospital | Changes in Cardiopulmonary exercise testing (CPET) | Changes in 6 minutes walking test (6MWT); Changes in Pulmonary function test (PFT); Changes in 36-Item Short Form Survey (SF-36) |
| NCT04836351 | Feasibility, Usefulness and Evaluation of a Concentrated Rehabilitation for Patients With Persistent Symptoms Post COVID-19 | UNKNOWN | nan | Western Norway University of Applied Sciences | Cardiopulmonary exercise test (CPET); Chalder Fatigue Questionnaire (CFQ) | International Physical Activity Questionnaire (IPAQ); Generalized Anxiety Disorder (GAD-7); Patient Health Questionnaire (PHQ-9); Bergen Insomnia Scale (BIS); Client Satisfaction Questionnaire (CSQ-8); Work and Social Adjustment Scale (WSAS); The Brief Illness |
| NCT06089876 | The Use of Step Tracker Mobile Applications in Overweight and Obese Adolescents for the Promotion of Physical Activity and the Improvement of Kinanthropometric Variables, Fitness a | UNKNOWN | nan | Universidad Católica San Antonio de Murcia | Physical Activity Level; Use of internet; Use of mobile phone; Handgrip Strength; VO2 max.; Countermovement jump (CMJ); Hamstrings flexibility; Speed; Curl-up; Push-up; Height; Weight; Fat mass; Fat-free mass; BMI | User version of the Mobile Application Rating Scale |
| NCT ID | Title | Status | Phase | Sponsor | Primary endpoint | Secondary endpoint |
|---|---|---|---|---|---|---|
| NCT03674541 | The Exercise Response to Pharmacologic Cholinergic Stimulation in Myalgic Encephalomyelitis / Chronic Fatigue Syndrome | COMPLETED | PHASE2 | Brigham and Women's Hospital | Change in Peak Oxygen Uptake (Peak VO2) Between the First and Second iCPET | Peak-Rest Oxygen Uptake (VO2); Peak Cardiac Output (Qc); Peak-Rest Cardiac Output (Qc); Peak Right Atrial Pressure (RAP); Peak-Rest Right Atrial Pressure (RAP); Peak Pulmonary Arterial Wedge Pressure (PAWP); Peak Stroke Volume (SV); Peak (Ca-vO2)/[Hgb]; Ventil |
| NCT05619653 | Randomised Placebo Controlled Clinical Trial of Efficacy of MYOcardial Protection in Patients With Postacute inFLAMmatory Cardiac involvEment Due to COVID-19 | ACTIVE_NOT_RECRUITING | PHASE3 | Valentina Puentmann | Left ventricular ejection fraction | Scar burden by late gadolinium enhancement (LGE); Cardiopulmonary exercise testing (CPET); Mean T1 and T2 mapping; LV Volume (ml/m2) and LV mass (g/m2); LV strain %; Aortic stiffness (PWV); Aortic wall imaging (LGE); Average Symptom Score (Modified CCS, NYHA, |
| NCT05618574 | Nitrite Supplementation to Mitigate Fatigability and Increase Function in Long COVID Patients | COMPLETED | PHASE2 | VA Office of Research and Development | Fatigability; Walking Efficiency | 400m Corridor Walk Test (400MCW); Short Performance Physical Battery (SPPB); Mitochondrial Respiration; Peak oxygen utilization (VO2) non-normalized; VO2 at anaerobic threshold (AT) non-normalized; Veterans RAND-12 (VR-12); Peak oxygen utilization (VO2) normal |
| NCT05218174 | Exercise Training and Functional, Cognitive, and Emotional Well-being in Adults with Post-Acute Sequelae of SARS-CoV-2 (COVID-19) Infection (PASC): a Randomized Controlled Trial | COMPLETED | nan | Baylor Research Institute | Peak Oxygen Consumption (VO2max), mL/min; Peak Oxygen Consumption (VO2max), mL/min; Peak Oxygen Consumption (VO2max), mL/min; Score on Cognitive Function Self-Assessment Scale (CFSS); Score on Cognitive Function Self-Assessment Scale (CFSS); Score on Cognitive | Duration, mm:ss; Duration, mm:ss; Duration, mm:ss; Peak VO2 (absolute), mL/min; Peak VO2 (absolute), mL/min; Peak VO2 (absolute), mL/min; Peak VO2 (relative), mL/kg/min; Peak VO2 (relative), mL/kg/min; Peak VO2 (relative), mL/kg/min; Metabolic Equivalents; Met |
| NCT05699538 | Fatigue and Fatigability in Veterans Following SARS-CoV-2 Infection | COMPLETED | nan | VA Office of Research and Development | Performance fatigability | Rating of Perceived Fatigue (RPF); Isometric and Isokinetic Knee Extensor Torque; Skeletal muscle oxygen extraction; Feeling Scale; Fatigue Severity Scale (FSS); Short Physical Performance Battery (SPPB); 30-second sit-to-stand; Six Minute Walk Test (6MWT); Mo |
| NCT06172803 | RESToRE: Restoring Energy With Sub-symptom Threshold Optimized Rehabilitation Exercise for Long COVID | COMPLETED | nan | Columbia University | Number of participants who enrolled; Number of participants who completed; Number of participants who adhered to session attendance | PROMIS-29 scale score; Rand 36-Item Health Survey (SF-36) score; VO2 % predicted from Cardiopulmonary Exercise Testing (CPET); Number of participants with orthostatic hypocapnia.; EuroQol: Education Quotient-5D Visual Analogue Scale score; General Symptom Ques |
| NCT06933017 | Feasibility Study of the Augmented Two-Day 6-Minute Incremental Step Test and Causal Exploration Through a Directed Acyclic Graph and Structural Equation Model for Post-Exertional | COMPLETED | nan | Universitair Ziekenhuis Brussel | Difference in oxygen uptake at peak (VO2 peak) between day 1 and day 2 measured with the CPET compared to measured with the Calibre device; Difference in Rate of Perceived Exertion (RPE) measured with the CPET compared to measured with the Calibre device; Rest | Change from Day 1 to Day 2 in Oxygen Uptake at First Ventilatory Threshold (VO₂ in ml/min/kg) during experimental session 1 or 2 (CPET); Change from Day 1 to Day 2 in Oxygen uptake at peak (VO2 in ml/min/kg) during experimental session 1 and 2 (CPET & 6MIS |
| NCT06631287 | Randomized Double-Blind Placebo-Controlled Trial EValuating Baricitinib on PERSistent NEurologic and Cardiopulmonary Symptoms of Long COVID (REVERSE-LC) | RECRUITING | PHASE3 | Wes Ely | CNS-Vital Signs Global Cognitive Index | Objective neuropsychological function domains of executive function, memory, processing speed, and motor speed including the CNS-Vital Signs subscale tests at 6-months.; Objective neuropsychological function domains of executive function, memory, processing sp |
| NCT03365414 | A Double Blind Randomized Controlled Crossover Study to Systematically Assess the Efficacy and Safety of Intravenous Albumin Infusions in Severe Postural Orthostatic Tachycardia Sy | WITHDRAWN | PHASE3 | University of Alberta | Severity of Orthostatic Intolerance | Disability Assessment; Degree of cardiovascular improvement - Heart rate; Degree of cardiovascular improvement - Pulse; Change in maximal exercise capacity - Cardiopulmonary exercise testing; Change in maximal exercise capacity - Electrocardiogram; Change in m |
| NCT05530317 | CArdiac REhabilitation for Building Exertional heArt Rate for Chronotropic Incompetence in Long COVID-19 (CARE BEAR-LC): A Proof-of-Concept, Mechanistic Trial | RECRUITING | nan | University of California, San Francisco | Change in adjusted heart rate reserve; Change in Peak VO2 (ml/kg/min) | Change in Peak VO2 (percent predicted); Number of Cardiac Rehabilitation sessions attended; Change in Proportion with peak VO2 less than 85% predicted; Change in Number of Long COVID symptoms; Change in Composite Autonomic Symptom Scale-31 (Compass 31) Score; |
| NCT05858515 | REVERSE-Long COVID: A Multicenter Randomized, Placebo-Controlled Clinical Trial of Immunomodulation (With Baricitinib) for Long COVID Related Cognitive Impairment and ADRD (Alzheim | WITHDRAWN | PHASE3 | Vanderbilt University Medical Center | Enrollment; Diversity in enrollment; Study drug prescribed; Study withdrawals; Adverse event reporting; Study dosing; Study completion | Severe and Serious Adverse Events; Premature study discontinuation; Global Neuropsychological Function; Cardiopulmonary testing; Everyday Cognition; Functional Status; Quality of Life Measures; Post-Exertional Malaise; Shortness of Breath; Symptom Burden; Infl |
| NCT05445531 | Low-field Magnetic Resonance Imaging to Assess Changes in Pulmonary Function Parameters in Confirmed Pediatric SARS-CoV-2 Infection | UNKNOWN | nan | University of Erlangen-Nürnberg Medical School | Functional lung assessment (LF-MRI) | Morphologic lung assessment (LF-MRI); Cardiological functional diagnostics (VO2); Cardiological functional diagnostics (VO2max); Cardiological functional diagnostics (VT2); Cardiological functional diagnostics (VCO2); Cardiological functional diagnostics (HR); |
| NCT06404411 | A Study of the Efficacy of Aerobic Exercise Based on Cardiopulmonary Exercise Test in the Rehabilitation of Patients With COVID-19-Related Myocardial Injury | UNKNOWN | nan | Chengdu Sport University | VO2peak | METpeak; AT; VEpeak; BR; VO2/HRpeak; Six-minute walk test distance, 6MWD; SDNN; SDANN; RMSSD; physical composite scale，PCS; mental health composite scale，MCS |
| NCT06042777 | Testing Non-pharmacological TCM-based Treatments for Cognitive Impairment in People With Long COVID Symptoms: A Randomized Controlled Trial | UNKNOWN | nan | The Hong Kong Polytechnic University | Global cognitive function | Global cognitive function; Cardiopulmonary function; Fatigue; Health-related quality-of-life; Psychological distress; Neurocognitive functions; Neurobiological outcomes |
| NCT05130099 | A Complex Intervention for a Complex Symptom - a Randomized Controlled Trial in Chronically Fatigued Lymphoma Survivors | UNKNOWN | nan | Oslo University Hospital | Difference in change in fatigue levels (physical-, mental- and total fatigue) between intervention and control group, assessed by the Chalder Fatigue Questionnaire | Difference in change in fatigue levels between groups assessed by Chalder Fatigue Questionnaire; Difference in change in fatigue levels between groups assessed by Chalder Fatigue Questionnaire; Change in fatigue levels among all participants assessed by Chalde |
| NCT ID | Title | Status | Phase | Sponsor | Primary endpoint | Secondary endpoint |
|---|---|---|---|---|---|---|
| NCT05445427 | Outcomes of Treatment With Vagal Nerve Stimulation in Post-COVID Syndrome: A Pilot Study | COMPLETED | nan | Mayo Clinic | Change in Post-COVID Functional Status Score | Change in PROMIS Fatigue Scale T Score |
| NCT05445674 | Plasma Exchange Therapy for Post- COVID-19 Condition: A Pilot, Randomized Double-Blind Study | COMPLETED | PHASE2 | Fundación FLS de Lucha Contra el Sida, las Enfermedades Infecciosas y la Promoción de la Salud y la Ciencia | Evaluate the safety and tolerability of PE in patients with Post-Acute Covid-19 Syndrome (PCC) comparing to sham plasma exchange (placebo); Proportion of subjects with Grade 0, 1 o 2 functional disability assessed by the functional status scale (PCFS); Proport | Assess the ability of PE to improve PCC symptoms; Assess the impact of PE on quality of life in subjects with PCC; Assess the impact of PE on quality of life in subjects with PCC using MOS-HIV questionnaire; Assess the impact of PE on neurocognitive symptoms i |
| NCT05323331 | Effects of Circuit Training Program on Cardiopulmonary Parameters and Functional Capacity in Post COVID 19 Patients | COMPLETED | nan | Riphah International University | 6 Minutes Walk Test; 6 Minutes Walk Test; Rate of Perceived Exertion (RPE 6-20):; Rate of Perceived Exertion (RPE 6-20):; Post-Covid Functional Status Scale (PCFS); Post-Covid Functional Status Scale (PCFS) | nan |
| NCT05543551 | Effects of Diaphragmatic Breathing With and Without Resistance Program on Functional Capacity and Activity of Daily Living in Post Covid Patients. | COMPLETED | nan | Riphah International University | Post Covid Functional Status (PCFS):; Barthel Index for Activity of daily living; Pulse Oximetry | nan |
| NCT05373407 | A Randomized Controlled Trial Examining the Impact of Low Versus Moderate-intensity Aerobic Training in Post-discharge COVID-19 Older Subjects | COMPLETED | nan | University of Hail | Distance walked in the 6-min walk test (6 MWT); Post-Covid Functional Scale (PCFS) | Number of repetitions performed in a 1-min Sit-to-Stand (STS) test; 2. Anxiety and Depression evaluated by the HAMLITON ScAnxiety and Depressionale (HADS); Quality of life SF-36 |
| NCT05841498 | A Single-blinded Sham-controlled Crossover Trial to Evaluate the Effect of Immunoadsorption on Post-Corona Virus Disease (COVID)-Syndrome | COMPLETED | nan | University Medical Center Mainz | Improvement of Post-COVID symptoms as measured by PCFS score; Change of physical and/or mental fatigue as measured by Chalder-Fatigue-scale; Change of impairment due to fatigue as measured by Bell-Score; Change of physical and/or mental fatigue as measured by | number of treatment-emergent adverse events (TEAE), serious adverse events and discontinuation of therapy because of adverse events; Prevalence of anti-adrenergic and anti-muscarinic autoantibodies in patients with PCS:; 3. Concentration of autoantibodies befo |
| NCT05630339 | Efficacy and Security of the Magnesium and Vitamin D Combination as Adjuvant Treatment of Post-COVID Syndrome. A Randomised Double-blind Clinical Trial | COMPLETED | nan | Coordinación de Investigación en Salud, Mexico | Change from Baseline Post-COVID syndrome symptoms at 4 months; Change from Baseline Post-COVID Functional Status at 4 months; Change from Baseline Serum vitamin D levels at 4 months; Change from Baseline Serum Magnesium levels at 4 months; Change from Baseline | Change from Baseline Fasting Blood Glucose levels at 4 months; Change from Baseline Serum Lipid Profile at 4 months; Change from Baseline Serum Calcium levels at 4 months; Change from Baseline Serum Creatinine levels at 4 months |
| NCT07374562 | Effect of Stellate Ganglion Block Treatment on Long COVID Symptoms: A Single-Blind, Single-Center Randomized Controlled Trial (STAR-CO) | RECRUITING | nan | Centre intégré universitaire de santé et de services sociaux de la Mauricie-et-du-Centre-du-Québec | Post-COVID-19 Functional Status Scale (PCFS); Fatigue Severity Scale (FSS); Brain Fog Scale (BFS) | Health-Related Quality of Life (SF-36); Dyspnea Severity (mMRC Scale); Lower-Limb Muscle Endurance (1-Minute Sit-to-Stand Test); Orthostatic Intolerance (NASA Lean Test) |
| NCT06168006 | Effects of a Physical Training Program Using a Mobile App on the Functionality and Cardiovascular Function of Individuals With Post-covid-19 Syndrome: Randomized Clinical Trial | RECRUITING | nan | University of Nove de Julho | Change from baseline in 6 min-walk test distance at 12 weeks; Change from baseline in Glittre test at 12 weeks; Change from baseline in sit and stand test at 12 weeks; Change from baseline in Post-Covid Functional Scale at 12 weeks | Change from baseline in Patient Functional Scale at 12 weeks; Change from baseline in Motor Evoked Potential at 12 weeks; Change from baseline in Modified Medical Research Dyspnea Scale at 12 weeks; Change from baseline in Chalder Physical Fatigue Scale at 12 |
| NCT05419219 | Effectiveness of Multi-domain Tai Chi Digital Therapy for Survivors Affected by the Sequelae of Covid-19 (TaiChi-DTx and Long Covid) | UNKNOWN | nan | Tim Shi | Change in Physical Activity ability measured by 6-minute walking distance measurement (6MWT); Overall respiratory relief measured by the Post-COVID-19 Functional Status (PCFS) Scale; Cognitive impairment improvement measured by the well-validated neuropsycholo | Change in number of hours/days absent from work related to Long COVID symptoms survey by web-based questionnaires (time frame 6 months after SARS-CoV-2 infection) |
| NCT04811859 | The Effect of Inspiratory Muscle Training on Respiratory Muscle Strength, Respiratory Functions and Functional Capacity in Post COVID-19 Patients | UNKNOWN | nan | Istinye University | PostCovid Functional Status Scale; Pulmonary Function Test; Inspiratory muscle strength; Functional capacity; Expiratory muscle strength | nan |
| NCT ID | Title | Status | Phase | Sponsor | Primary endpoint | Secondary endpoint |
|---|---|---|---|---|---|---|
| NCT06721949 | Taurine Supplementation as a Novel Therapeutic Approach for Neurocognitive Symptoms in Long COVID | RECRUITING | PHASE2; PHASE3 | University of Alberta | Mean change in Modified Fatigue Impact Scale (MFIS) from baseline to three months; Mean change in the ratio of the Trail-Making Tests A & B in the TestMyBrain cognitive testing battery from baseline to three months. | Core Outcome Set - Symptoms; Cardiovascular function; Respiratory function; Cognitive Function; Memory; Concentration; Conceptual Thinking; Social Functioning; Mental Health Status - PHQ-9; Mental Health Status - GAD-7; Post-Exertional Malaise (PEM) Symptoms; |
| NCT05107440 | BREATHE: A Mixed-methods Evaluation of a Virtual Self-management Program for People Living With Long COVID-19 in Alberta | COMPLETED | nan | University of Calgary | Self-efficacy to manage symptoms; Self-efficacy to manage daily activities; Self-efficacy to manage emotions | Self-efficacy to manage symptoms; Self-efficacy to manage daily activities; Self-efficacy to manage emotions; Fatigue severity (FACIT-F); Fatigue severity (FACIT-F); Medical Research Council (MRC) breathlessness scale grade; Medical Research Council (MRC) brea |
| NCT06814379 | Rehabilitation of Fatigue in Patients With Post-COVID-19 Syndrome | COMPLETED | nan | Universidad de Granada | Perceived Fatigue; Multidimensional Fatigue; Fatigue Severity; Fatigue Impact | COVID-19 information; Comorbidities; Dyspnea. The Borg Modified Scale; Dyspnea. Dyspnea-12; Dyspnea. Modified Medical Research Council (mMRC) Dyspnea Scale; Pain intensity; Psychological status; Sleep quality; Health-related Quality of life; Functional status: |
| NCT04841759 | The Effects of a Multi-factorial Rehabilitation Program for Healthcare Workers Suffering From Post-COVID-19 Fatigue Syndrome | COMPLETED | nan | Medical University of Vienna | Change of maximum oxygen uptake (VO2max) over time-points (baseline - 4 weeks - 8 weeks) assessed during cardio-pulmonary exercise testing (CPET) | Change of walking distance during a six minutes walk test (6MWT) over time-points (baseline - 4 weeks - 8 weeks); Change of numbers over time-points (baseline - 4 weeks - 8 weeks) how often someone can stand up and sit down on a chair within 30 seconds during |
| NCT06590324 | A Phase II, Multi-centre Open Label Study to Assess the Efficacy and Safety of Oral Apabetalone With Background Dapagliflozin in Subjects With Long -COVID-19 (Post-COVID-19 Conditi | RECRUITING | PHASE2; PHASE3 | Resverlogix Corp | patient acceptable symptom state (PASS) | Long COVID Symptom and Impact tools (LCST/LCIT); Patient-Reported Outcomes Measurement Information System (PROMIS)-Fatigue Short Form 7a (SF-7a); Baseline Dyspnea Index (BDI) & Transition Dyspnea Index (TDI); Post-COVID-19 Functional Status (PCFS) Scale; D |
| NCT05254301 | Faster Functional Performance Recovery After Individualized Nutrition Therapy Combined With a Patient-tailored Physical Rehabilitation Program Versus Standard Physiotherapy in Pati | COMPLETED | nan | Universitair Ziekenhuis Brussel | 1-minute sit-to-stand (1-MSTS) | Multi-dimensional Fatigue Inventor (MFI-20); EuroQol five-dimensional (five-level version) (EQ-5D-5L); Post-COVID-19 Functional Status (PCFS); Hospital Anxiety and Depression Scale (HADS); Work Productivity and Activity Impairment (WPAI) |
| NCT04794036 | Efficacy of an Asynchronous Telerehabilitation Programme in Post-COVID-19 Patients: a Feasibility Study | COMPLETED | nan | Universidad San Jorge | Fatigue Severity Level | Adherence; Engagement; Satisfaction level; Incidents; Maximum Leg Strength Endurance; Maximum Arm Strength Endurance; Submaximum Aerobic Capacity Walking; Post-COVID Functional Status; Depression, Anxiety and Stress; Self-efficacy; Behavior in sport; Perceived |
| NCT05172206 | Symptom-based Rehabilitation Compared to Usual Care in Post-COVID - a Randomized Controlled Trial | COMPLETED | nan | Schön Klinik Berchtesgadener Land | Change from baseline Quality of life assessed by Short Form - 12 Questionnaire at week 4 and week 12 | Change from baseline COVID-related symptoms at week 4 and week 12; Change from baseline lung function at week 4 and week 12; Change from baseline blood gas analysis at week 4 and week 12; Change from baseline Cardiac Doppler echocardiography at week 4 and week |
| NCT06601920 | A Study of Activity Leader to Forest Therapy Campaign in Different Environments Targets on the Participants Which Had Been Infected by SARS-COV-2 | COMPLETED | nan | Taipei City Hospital | Profile of Mood States 2nd Edition-Adult Short, POMS; The Beck Anxiety Inventory, BAI; The Beck Depression In- ventory-Second edition, BDI-II; The brief World Health Organization Quality of Life, WHOQOL-BREF; Fear of COVID-19 Scale, FCV-19S; Salivary Amylase E | Post-COVID Functional Status, PCFS; Blood pressure, Heart rate, and Heart rate variability |
| NCT06766825 | Phase II Proof-of-concept, Randomized, Double-blind, Placebo-controlled Study to Evaluate the Efficacy and Safety of Plitidepsin in Adults With Post-COVID-19 Condition (PCC) | RECRUITING | PHASE2 | Fundación FLS de Lucha Contra el Sida, las Enfermedades Infecciosas y la Promoción de la Salud y la Ciencia | Change in the overall health in patients from each group using patient reported outcomes measurement information system score (PROMIS-29®). | To compare the safety/tolerability of Plitidepsin Vs placebo in terms of adverse events in patients with PCC.; To compare the incidence of Treatment-Emergent Adverse Events (TEAEs) between groups.; To compare changes in the overall health in patients from each |
| NCT05918965 | Effects of Transcutaneous Electrical Neurostimulation on Female Patients With Long COVID - a Pilot Study | UNKNOWN | nan | Medical University of Vienna | Heart rate variability | blood pressure and pulse; Saliva cortisol; Questionnaire Brief Fatigue Inventory (BFI); Questionnaire Short form (SF)-36; Questionnaire Borg-Scale; Questionnaire Insomnia Severity Index (ISI); Post-COVID-19 Functional Status scale (PCFS) |
| NCT05150782 | The Effect of a Mixture of Micellized Curcumin/Boswellia Serrata/Ascorbic Acid on Health-related Quality of Life in Patients With Post-acute COVID-19 Syndrome. | UNKNOWN | nan | PhysioMetrics | Change in health-related quality of life | Change in patient selected functional limitations in daily life, measured with the 'Patient specific functional scale (PSFS).; Change in general health status; Change in general health; Change in Post COVID functional status measured with the 'Post C |
| NCT05360563 | Effects of a Home-based Exercise Program on the Functional Sequelae of Patients With the Post-COVID-19 Condition: A Randomized Controlled Trial | UNKNOWN | nan | University of Sao Paulo | Change from baseline in functional fitness assessed by distance walked (m) in the six-minute walk test (6MWT) at 16 weeks. | Change from baseline in six-minute walk work (kg.km) assessed by 6MWT at 16 weeks.; Change from baseline in maximal inspiratory muscle strength (cmH2O) assessed by POWERbreathe device at 16 weeks.; Change from baseline in forced vital capacity (FVC; L) assesse |
| NCT ID | Title | Status | Phase | Sponsor | Primary endpoint | Secondary endpoint |
|---|---|---|---|---|---|---|
| NCT05524532 | Effect of Immulina Supplements on Inflammatory Biomarkers Correlated With Clinical Symptoms in Patients With Long COVID (PASC) | COMPLETED | PHASE3 | University of Mississippi Medical Center | Plasma IL-6 (Interleukin 6, pg/mL); Plasma CRP (C-Reactive Protein, ng/mL); Plasma D-Dimer, pg/mL | PROMIS-29; FSS; SBQ-LC TM; SARS-CoV-2-specific antibody responses; SARS-CoV-2-specific immune responses on memory T cell levels; SARS-CoV-2-specific immune responses on memory B cell levels; Natural Killer cell (NK)-mediated cytotoxicity; Natural Killer (NK) c |
| NCT06004310 | Effect of Pulmonary Rehabilitation Among Post-COVID-19 Patients in a Tertiary Care Hospital in Bangladesh: A Quasi-Experimental Study | COMPLETED | nan | Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh | Distance: Six-minute walking test (6MWT); Respiratory outcomes: FVC, FEV1, FEV1/FVC ratio, DLCO; Quality of life: Short Form 36 Health Survey Questionnaire (SF-36); Laboratory investigations: CRP and D-dimer | nan |
| NCT ID | Title | Status | Phase | Sponsor | Primary endpoint | Secondary endpoint |
|---|---|---|---|---|---|---|
| NCT05877508 | An Exploratory, Randomized, Double-Blind Placebo-Controlled Study to Assess the Safety of an Anti-SARS-CoV-2 Monoclonal Antibody and Response to Treatment in Individuals With Long | ACTIVE_NOT_RECRUITING | PHASE2 | Michael Peluso, MD | Patient-Reported Outcomes Measurement Information System (PROMIS)-29 Physical Health Summary Score | Patient-Reported Outcomes Measurement Information System (PROMIS)-29 Physical Health Summary Score; Patient-Reported Outcomes Measurement Information System (PROMIS)-29 Mental Health Summary Score; Patient-Reported Outcomes Measurement Information System (PROM |
| NCT05890534 | Pycnogenol® in People With Post-COVID-19 Condition: a Quadruple-blind, Randomized, Placebo-controlled Trial | COMPLETED | PHASE3 | University of Zurich | Health status (EQ-VAS) | Post COVID-19 symptoms; Fatigue; Dyspnea; Cognitive function; Anxiety and depression; Health-related quality of life (EQ-5D-5L); Functional exercise capacity; Physical activity; Soluble Thrombomodulin (sTM); von Willebrand Factor antigen (VWF:Ag); Syndecan-1; |
| NCT05228899 | A Phase I/II Multicenter, Randomized, Double Blinded, Placebo Trial to Evaluate the Safety and Potential Efficacy of Zofin Infused Intravenous (IV) in Patients Experiencing Prolong | COMPLETED | PHASE1; PHASE2 | ZEO ScientifiX, Inc. | Incidence of Severe Adverse Events | Fatigue Severity Score Score; Daily Diary of COVID-19 Related Symptom; COVID-19 Associated Symptoms Length; COVID-19 Associated Symptoms Mitigation; Beck Depression Inventory Score; Mental Fatigue Questionnaire Score; Pulse Oxygen Saturation; Heart Rate Variab |
| NCT05531019 | COVID-19 Sequelae: Treatment and Monitoring of Persistent Symptoms, a Decentralized Approach Focus on the Patient. Use of Dietary Supplement Based on Sea Urchin Eggs With Echinochr | COMPLETED | nan | Fernando Saldarini | Change of symptoms over time-points (baseline, 4 weeks, 8 weeks, 12 weeks) during rutine medical checkup.; Change of lung capacity over four times (baseline, 4 weeks, 8 weeks, 12 weeks) assessed during spirometry.; Change of walking distance during a six minut | Change of Von Willebrand Factor over time-points (baseline, 4 weeks, 12 weeks, 12 weeks) via blood sample.; Change of D Dimer over time-points (baseline, 4 weeks, 12 weeks, 12 weeks) via blood sample.; Change of HS-CRP over time-points (baseline, 4 weeks, 8 we |
| NCT04718506 | Rehabilitation for Post-COVID-19 Syndrome Through a Multicomponent, Educational and Supervised Exercise Intervention [RECOVE] | COMPLETED | nan | Universidad de Murcia | Changes in subject clinical status | Changes in cardiovascular fitness: Maximal oxygen consumption (VO2max); Changes in neuromuscular performance during resistance exercise: Barbell Mean Propulsive Velocity (MPV); Changes in balance: center of pressure (COP) sway; Changes in pulmonary function: F |
| NCT04797871 | Resistance Training Intervention on the Clinical Status in Patients With Post Discharge Symptoms After Covid-19: The "EXER-COVID Study" | COMPLETED | nan | Universidad Pública de Navarra | Changes in Cardiorespiratory fitness | Changes in Post-COVID manifestations; Changes in Blood samples analysed for markers related to low grade inflammation; Changes in pulse wave velocity; Changes in cardio-ankle vascular index (CAVI); Changes in Energy expenditure; Changes in bone mineral density |
| NCT04695704 | Double-blind Randomized Clinical Trial, Placebo-controlled to Assess the Efficacy of Montelukast in Mild-moderate Respiratory Symptoms in Patients With Long-COVID-19: E-SPERANZA CO | TERMINATED | PHASE3 | Fundacio d'Investigacio en Atencio Primaria Jordi Gol i Gurina | COP Assessment Test Scale (CAT) | 1min sit-to-stand test; O2 desaturation; Visual Analogical Scale (VAS); All-cause mortality; Number of visits to primary care; Number of visits to the emergency room; Number of hospital admissions.; Medication side effects; Days of sick leave; Factors of infla |
| NCT06766825 | Phase II Proof-of-concept, Randomized, Double-blind, Placebo-controlled Study to Evaluate the Efficacy and Safety of Plitidepsin in Adults With Post-COVID-19 Condition (PCC) | RECRUITING | PHASE2 | Fundación FLS de Lucha Contra el Sida, las Enfermedades Infecciosas y la Promoción de la Salud y la Ciencia | Change in the overall health in patients from each group using patient reported outcomes measurement information system score (PROMIS-29®). | To compare the safety/tolerability of Plitidepsin Vs placebo in terms of adverse events in patients with PCC.; To compare the incidence of Treatment-Emergent Adverse Events (TEAEs) between groups.; To compare changes in the overall health in patients from each |
| NCT04712279 | High-Dose Ivermectin for Mild-to-Moderate COVID-19 - The (HD)IVACOV Trial | UNKNOWN | PHASE2; PHASE3 | Corpometria Institute | World Health Organization (WHO) Clinical Progression Scale [0 to 10; 0 = uninfected; 10 = death] | World Health Organization (WHO) COVID=19 Ordinal Scale for Clinical Improvement [1 to 8; 1 = not hospitalized, no limitation on activities; 8 = death] [Time Frame: Day 7]; Time-to-recovery; Viral load; Positivity rate of rtPCR-SARS-CoV-2 (qualitative analysis) |
| NCT05890599 | Randomized Multicenter Clinical Trial: Yoga Versus Health Education for the Treatment of Persistent Fatigue in Patients With Post COVID-19 Syndrome | RECRUITING | nan | University Hospital Tuebingen | Fatigue | Fatigue; Health related quality of life SF-12; Health related quality of life SF-12; Health related quality of life EQ-5D-5L; Health related quality of life EQ-5D-5L; Psychological symptoms; Psychological symptoms; Sleep quality; Sleep quality; Stress; Stress; |
| NCT06065033 | Exercise as a Therapeutic for Those Diagnosed With Post-acute Sequelae of Covid-19 | WITHDRAWN | nan | University of Virginia | VO2peak; Left ventricular strain; Left ventricular diastolic function | Forced expiratory volume in one second (FEV1); Forced vital capacity (FVC); Post COVID-19 Functional Status scale; Symptom Burden Questionnaire for Long Covid (SBQ-LC); International Physical Activity Questionnaire (IPAQ); NTproBNP; C-reactive protein (CRP); L |
| NCT05669261 | A PILOT STUDY ON RESEARCH TREATMENT OF LONG COVID POST-ACUTE SEQUELAE OF SARS CoV-2 INFECTION ("PASC") USING ATCell™ | UNKNOWN | PHASE1 | American CryoStem Corporation | Assessment of the Incidence of Serious Adverse Events (SAEs); Assessment of change in Health Status using the 36 item Short Form Health Survey (SF-36); Assessment of change in Health Status using the 36 item Short Form Health Survey (SF-36); Assessment of chan | Assessment of Changes in Exosome/Cytokine/Chemokine Testing; Assessment of change in completion time -Six-minute walk test (6MWT); Assessment of Change in Complete blood count with differential (CBC with diff) Laboratory Testing Results; Assessment of Change i |
| NCT ID | Title | Status | Phase | Sponsor | Primary endpoint | Secondary endpoint |
|---|---|---|---|---|---|---|
| NCT05238415 | ASAP - Assisted Immediate Augmented Post-/Long-COVID Plan | COMPLETED | nan | Prof. Dr. Sonia Lippke | Change from baseline in the Post-/ Long-COVID symptoms at 3 months; Subjective prognosis of return to work | Activity and social participation; Health behaviors of daily living; Mental health; Life satisfaction |
| NCT ID | Title | Status | Phase | Sponsor | Primary endpoint | Secondary endpoint |
|---|---|---|---|---|---|---|
| NCT05244044 | Changes in Functional Exercise Capacity After PUlmonary REhabilitation in Primary Care: a Randomized, Controlled, Multicenter, Pragmatic Trial in 134 Patients With Long COVID (PuRe | COMPLETED | nan | University Hospital, Antwerp | Exercise capacity | Change in physical activity; Change in COVID-19 related symptoms; Change in quality of life; Change in fatigue; Change in dyspnoea; Change in functional status; Change in work productivity and activity impairment.; Change in anxiety and depression symptoms.; C |
| NCT05254301 | Faster Functional Performance Recovery After Individualized Nutrition Therapy Combined With a Patient-tailored Physical Rehabilitation Program Versus Standard Physiotherapy in Pati | COMPLETED | nan | Universitair Ziekenhuis Brussel | 1-minute sit-to-stand (1-MSTS) | Multi-dimensional Fatigue Inventor (MFI-20); EuroQol five-dimensional (five-level version) (EQ-5D-5L); Post-COVID-19 Functional Status (PCFS); Hospital Anxiety and Depression Scale (HADS); Work Productivity and Activity Impairment (WPAI) |
| NCT06643299 | PURE-LC - Probiotic Use for Recovery Enhancement From Long COVID | ACTIVE_NOT_RECRUITING | PHASE2 | Rush University Medical Center | Difference in Long COVID Severity | Difference in LC-SSS Total Score; Difference in Quality of Life; Difference in Return to Work and Activity |
| NCT06570239 | Efficacy of Spa Management (Hydrokinesitherapy and Crenobalneotherapy) Compared With Usual Management of People With Post-Covid-19 Conditions: a Randomized, Open-label Clinical Tri | NOT_YET_RECRUITING | nan | Central Hospital, Nancy, France | Primary Outcome | Utility score (EQ-5D-5L); Number of symptoms and symptoms clusters; Return to work; Medical consultations |
Two views of the intervention → outcome relationships the corpus already supports. The network view (top) is a force-directed layout with intervention nodes colored by CT.gov type — drugs in pink, behavioral in teal, devices in blue, procedures in amber — and outcomes as navy diamonds. Hub interventions (Acupuncture, Exercise) emerge in the dense centre; peripheral interventions like Stellate Ganglion Block sit at the edge anchored to a single outcome. The adjacency matrix (bottom) shows every co-occurrence including the 28 weak (single-trial) connections — empty or pale cells are coverage gaps the KG can flag. Across 746 trials, the strongest edge is Acupuncture → Cognitive (6 trials). Comparator arms (placebo, usual care, sham) are excluded from the intervention column. The full KG holds every (intervention, outcome, evidence_weight) triple plus population, study, and citation links — these views are one slice.
RCR is available for 5559 articles (73%). Median RCR = 1.05. 2860 articles cite above their field average (RCR > 1.0); 1568 are high-impact (RCR > 2.0). The histogram is clipped at the 99th percentile (15.53) for readability; 56 articles exceed that display limit, with maximum RCR = 414.09. Unlike raw citation counts, RCR controls for both publication year and field, so a 2026 paper with 2 citations can outrank a 2022 paper with 50 if it's cited at a higher rate for its age and topic. Better signal for evidence weighting in a young corpus.
Where records exist but are missing fields they should have. Trials without results are the biggest signal — that's evidence registered but not yet usable for the KG.
GPT was used as an AI-assistance, to complement what was missing from the search keyword terms and the fetched clincial trials.
Number of AI-detected IDs
GPT proposed new terms that could be reviewd and added to the search scope.
| Term | Why GPT proposed it | Confidence | Source file |
|---|---|---|---|
| Post-COVID terminology (17) | |||
GPCR autoantibodies | GPCR autoantibodies are implicated in the pathophysiology of Long COVID, as discussed in studies on autoantibody profiles. | self-rated confident | 2026-05-08T08-07-27Z_suggested_terms.yaml |
β1/β2-adrenergic receptor autoantibodies | Anti-β2AR autoantibodies have been identified in Long COVID patients, as seen in studies exploring autonomic dysfunction. | self-rated confident | 2026-05-08T08-07-27Z_suggested_terms.yaml |
M2/M3/M4-muscarinic acetylcholine receptor autoantibodies | These autoantibodies are studied for their role in dysautonomia in Long COVID, as reported in recent research. | self-rated confident | 2026-05-08T08-07-27Z_suggested_terms.yaml |
AT1R autoantibody | AT1R autoantibodies are associated with vascular and autonomic symptoms in Long COVID, as noted in clinical studies. | self-rated confident | 2026-05-08T08-07-27Z_suggested_terms.yaml |
ETAR autoantibodies | ETAR autoantibodies are explored in the context of endothelial dysfunction in Long COVID. | self-rated confident | 2026-05-08T08-07-27Z_suggested_terms.yaml |
Anti-ACE2 autoantibodies | Anti-ACE2 autoantibodies are investigated for their potential role in Long COVID pathophysiology. | self-rated confident | 2026-05-08T08-07-27Z_suggested_terms.yaml |
Dysautonomia | Dysautonomia is a common symptom in Long COVID, frequently mentioned in clinical assessments. | self-rated confident | 2026-05-08T08-07-27Z_suggested_terms.yaml |
POTS | Postural Orthostatic Tachycardia Syndrome (POTS) is a recognized condition in Long COVID patients. | self-rated confident | 2026-05-08T08-07-27Z_suggested_terms.yaml |
small-fibre neuropathy | Small-fibre neuropathy is reported in Long COVID, as seen in neurological evaluations. | self-rated confident | 2026-05-08T08-07-27Z_suggested_terms.yaml |
post-exertional malaise | Post-exertional malaise is a hallmark symptom of Long COVID, similar to ME/CFS. | self-rated confident | 2026-05-08T08-07-27Z_suggested_terms.yaml |
myalgic encephalomyelitis | Myalgic encephalomyelitis is often studied alongside Long COVID due to symptom overlap. | self-rated confident | 2026-05-08T08-07-27Z_suggested_terms.yaml |
chronic fatigue syndrome | Chronic fatigue syndrome shares clinical features with Long COVID, making it relevant for comparative studies. | self-rated confident | 2026-05-08T08-07-27Z_suggested_terms.yaml |
ME/CFS | ME/CFS is frequently referenced in Long COVID research due to overlapping symptoms. | self-rated confident | 2026-05-08T08-07-27Z_suggested_terms.yaml |
PASC-CFS | PASC-CFS is a term used to describe chronic fatigue syndrome-like symptoms in Long COVID. | self-rated confident | 2026-05-08T08-07-27Z_suggested_terms.yaml |
cognitive dysfunction | Cognitive dysfunction, or 'brain fog', is a common symptom in Long COVID studies. | self-rated confident | 2026-05-08T08-07-27Z_suggested_terms.yaml |
brain fog | Brain fog is a colloquial term for cognitive dysfunction in Long COVID patients. | self-rated confident | 2026-05-08T08-07-27Z_suggested_terms.yaml |
orthostatic intolerance | Orthostatic intolerance is a symptom frequently reported in Long COVID and ME/CFS. | self-rated confident | 2026-05-08T08-07-27Z_suggested_terms.yaml |
| Interventions (26) | |||
BC 007 | BC 007 is an aptamer-based therapy targeting autoantibodies, under investigation for Long COVID. | self-rated confident | 2026-05-08T08-07-27Z_suggested_terms.yaml |
rovunaptabin | Rovunaptabin is an emerging therapy for autoantibody neutralization in Long COVID. | self-rated uncertain | 2026-05-08T08-07-27Z_suggested_terms.yaml |
daratumumab | Daratumumab, an anti-CD38 monoclonal antibody, is explored for plasma-cell depletion in Long COVID. | self-rated confident | 2026-05-08T08-07-27Z_suggested_terms.yaml |
efgartigimod | Efgartigimod is an FcRn inhibitor being studied for its potential in autoantibody-mediated diseases like Long COVID. | self-rated confident | 2026-05-08T08-07-27Z_suggested_terms.yaml |
immunoadsorption | Immunoadsorption is a therapeutic apheresis technique used in Long COVID to remove autoantibodies. | self-rated confident | 2026-05-08T08-07-27Z_suggested_terms.yaml |
TheraSorb | TheraSorb is a specific immunoadsorption column used in trials for autoantibody removal in Long COVID. | self-rated confident | 2026-05-08T08-07-27Z_suggested_terms.yaml |
Globaffin | Globaffin is another immunoadsorption column used in Long COVID studies. | self-rated confident | 2026-05-08T08-07-27Z_suggested_terms.yaml |
Ig-Adsopak | Ig-Adsopak is used in immunoadsorption for autoantibody removal in Long COVID. | self-rated confident | 2026-05-08T08-07-27Z_suggested_terms.yaml |
therapeutic plasma exchange | Therapeutic plasma exchange is used to treat autoantibody-mediated conditions in Long COVID. | self-rated confident | 2026-05-08T08-07-27Z_suggested_terms.yaml |
plasmapheresis | Plasmapheresis is a procedure used in Long COVID to manage autoantibody-related symptoms. | self-rated confident | 2026-05-08T08-07-27Z_suggested_terms.yaml |
rituximab | Rituximab is a B-cell depleting agent studied in Long COVID for its immunomodulatory effects. | self-rated confident | 2026-05-08T08-07-27Z_suggested_terms.yaml |
ocrelizumab | Ocrelizumab, similar to rituximab, is explored for B-cell depletion in Long COVID. | self-rated confident | 2026-05-08T08-07-27Z_suggested_terms.yaml |
intravenous immunoglobulin | Intravenous immunoglobulin (IVIG) is used in Long COVID for its immunomodulatory properties. | self-rated confident | 2026-05-08T08-07-27Z_suggested_terms.yaml |
low-dose IVIG | Low-dose IVIG is being trialed for its potential benefits in Long COVID. | self-rated confident | 2026-05-08T08-07-27Z_suggested_terms.yaml |
SCIG | Subcutaneous immunoglobulin (SCIG) is an alternative to IVIG in Long COVID treatment. | self-rated confident | 2026-05-08T08-07-27Z_suggested_terms.yaml |
rozonalixizumab | Rozonalixizumab is an FcRn inhibitor under investigation for autoantibody-mediated diseases. | self-rated uncertain | 2026-05-08T08-07-27Z_suggested_terms.yaml |
nipocalimab | Nipocalimab is another FcRn inhibitor being studied for its role in Long COVID. | self-rated confident | 2026-05-08T08-07-27Z_suggested_terms.yaml |
nanobody | Nanobodies are being developed to target specific autoantibody clones in Long COVID. | self-rated confident | 2026-05-08T08-07-27Z_suggested_terms.yaml |
monoclonal antibody | Monoclonal antibodies are used to target specific autoantibodies in Long COVID. | self-rated confident | 2026-05-08T08-07-27Z_suggested_terms.yaml |
RECOVER-VITAL | RECOVER-VITAL is a platform trial arm investigating interventions for Long COVID. | self-rated confident | 2026-05-08T08-07-27Z_suggested_terms.yaml |
STIMULATE-ICP | STIMULATE-ICP is a trial arm focusing on interventions for Long COVID. | self-rated confident | 2026-05-08T08-07-27Z_suggested_terms.yaml |
PANORAMIC follow-up | PANORAMIC follow-up arms are part of ongoing research into Long COVID treatments. | self-rated confident | 2026-05-08T08-07-27Z_suggested_terms.yaml |
RituxME | RituxME is a trial investigating rituximab for ME/CFS, relevant to Long COVID research. | self-rated confident | 2026-05-08T08-07-27Z_suggested_terms.yaml |
IA-PACS-CFS | IA-PACS-CFS is a trial exploring immunoadsorption in ME/CFS and Long COVID. | self-rated confident | 2026-05-08T08-07-27Z_suggested_terms.yaml |
reCOVer trial | The reCOVer trial is a study on interventions for Long COVID. | self-rated confident | 2026-05-08T08-07-27Z_suggested_terms.yaml |
NCT05710770 | NCT05710770 is a registry ID for a trial related to Long COVID interventions. | self-rated confident | 2026-05-08T08-07-27Z_suggested_terms.yaml |
| Discard filters (3) | |||
case-control study | Case-control studies are observational and not the focus of RCT and intervention literature. | self-rated confident | 2026-05-08T08-07-27Z_suggested_terms.yaml |
qualitative study | Qualitative studies do not align with the focus on RCTs and pharmacological interventions. | self-rated confident | 2026-05-08T08-07-27Z_suggested_terms.yaml |
pilot study | Pilot studies are preliminary and not the primary focus of comprehensive RCT reviews. | self-rated confident | 2026-05-08T08-07-27Z_suggested_terms.yaml |
Each row is a real record detected by AI that was missing from evidence base.
| Kind | ID | Name | Intervention | Sponsor | Why GPT proposed it |
|---|---|---|---|---|---|
| trial | NCT05196451 | Short-time Behavioural Intervention in Post-Covid Syndrome (SIPCOV): A Pragmatic Randomised Controlled Trial | Rehabilitation based on CBT principles | University Hospital, Akershus | Evaluates the efficacy of a short-term outpatient rehabilitation program for post-COVID syndrome. |
| publication | 39462879 | Personalised Health Behaviour Support Programme in Adults With Post‐COVID Syndrome: A Randomised, Controlled Pilot Feasi | Reports on the feasibility and acceptability of a personalised health behaviour support programme for adults with post-COVID syndrome. | ||
| publication | 39978856 | Post-Hospitalisation COVID-19 Rehabilitation (PHOSP-R): a randomised controlled trial of exercise-based rehabilitation | Investigates the effectiveness of exercise-based rehabilitation in individuals with post-COVID syndrome following hospitalization. | ||
| publication | 36476156 | Effects of a concurrent training, respiratory muscle exercise, and self-management recommendations on recovery from post | Determines the effectiveness of physical exercise and respiratory muscle training on recovery from post-COVID-19 conditions. | ||
| publication | 39462879 | Personalised Health Behaviour Support Programme in Adults With Post‐COVID Syndrome: A Randomised, Controlled Pilot Feasi |
Every chatbot call writes a JSON transcript with the exact prompt, raw response, hashed payloads, model snapshot, and token usage — enabling full reproducibility of the corpus assembly process.
| Timestamp (UTC) | Tool | Model | Prompt tokens | Completion tokens | Response SHA-256 | Log file |
|---|---|---|---|---|---|---|
| 2026-05-10T18-45-28Z | chatbot_trial_discovery.py | gpt-4o | 0 | 0 | 0f4eb67bc977… | 2026-05-10T18-45-28Z_gpt-4o_discovery.json |
| 2026-05-10T18-42-07Z | chatbot_trial_discovery.py | gpt-4o | 0 | 0 | b0937efcc3c3… | 2026-05-10T18-42-07Z_gpt-4o_discovery.json |
| 2026-05-10T18-31-17Z | chatbot_trial_discovery.py | gpt-4o | 0 | 0 | 51e2aff726c3… | 2026-05-10T18-31-17Z_gpt-4o_discovery.json |
| 2026-05-08T08-07-27Z | chatbot_query_expansion.py | gpt-4o-2024-08-06 | 1,387 | 1,839 | fcf1f2cf0d06… | 2026-05-08T08-07-27Z_gpt-4o-2024-08-06_expansion.json |
| 2026-05-07T20-14-19Z | chatbot_trial_discovery.py | gpt-4o | 0 | 0 | e6679075ec69… | 2026-05-07T20-14-19Z_gpt-4o_discovery.json |
| 2026-05-07T20-08-00Z | chatbot_trial_discovery.py | gpt-4o-2024-08-06 | 387 | 1,737 | 93de29e345f9… | 2026-05-07T20-08-00Z_gpt-4o-2024-08-06_discovery.json |
| 2026-05-07T20-00-25Z | chatbot_trial_discovery.py | gpt-4o-2024-08-06 | 358 | 1,697 | d72f7ec11bc3… | 2026-05-07T20-00-25Z_gpt-4o-2024-08-06_discovery.json |
| 2026-05-07T19-51-50Z | chatbot_trial_discovery.py | gpt-4o-2024-08-06 | 358 | 1,702 | 90db8052aea6… | 2026-05-07T19-51-50Z_gpt-4o-2024-08-06_discovery.json |
| 2026-05-07T19-48-43Z | chatbot_trial_discovery.py | gpt-4o-2024-08-06 | 358 | 1,754 | 4f2931b52d21… | 2026-05-07T19-48-43Z_gpt-4o-2024-08-06_discovery.json |
| 2026-05-07T19-45-52Z | chatbot_trial_discovery.py | gpt-4o-2024-08-06 | 358 | 1,838 | 3b25bae43159… | 2026-05-07T19-45-52Z_gpt-4o-2024-08-06_discovery.json |
| 2026-05-01T17-12-34Z | chatbot_trial_discovery.py | gpt-4o-2024-08-06 | 416 | 1,543 | 24138ad3bcbe… | 2026-05-01T17-12-34Z_gpt-4o-2024-08-06_discovery.json |
| 2026-05-01T17-04-35Z | chatbot_trial_discovery.py | gpt-4o-2024-08-06 | 416 | 1,658 | 442ac751a39c… | 2026-05-01T17-04-35Z_gpt-4o-2024-08-06_discovery.json |
| 2026-05-01T17-03-56Z | chatbot_query_expansion.py | gpt-4o-2024-08-06 | 1,641 | 908 | ff1255d20705… | 2026-05-01T17-03-56Z_gpt-4o-2024-08-06_expansion.json |
| 2026-04-30T18-16-28Z | chatbot_trial_discovery.py | gpt-4o-2024-08-06 | 416 | 1,413 | e3790a55ee11… | 2026-04-30T18-16-28Z_gpt-4o-2024-08-06_discovery.json |
| 2026-04-30T18-03-59Z | chatbot_query_expansion.py | gpt-4o-2024-08-06 | 1,521 | 678 | 696bacf66977… | 2026-04-30T18-03-59Z_gpt-4o-2024-08-06_expansion.json |